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Paula I. Moreira received her PhD in Biomedical Sciences from University of Coimbra, Portugal, in 2007. Currently, she is Assistant Professor at the Faculty of Medicine and Principal Investigator at the Center for Neuroscience and Cell Biology, University of Coimbra, Portugal. Moreira's group is interested in elucidating the role of energy metabolism, with an emphasis on mitochondria (energy, homeostasis and signals) and metabolic hormones-mediated signaling pathways in brain changes occurring in metabolic disorders (e.g. diabetes and obesity) and neurodegenerative diseases, particularly Alzheimer disease. We are also interested in clarifying the role of hypoxia and sex/gender in the neurodegenerative events that characterize these pathologies. Additionally, we are exploring the therapeutic potential of anti-diabetic drugs, metabolic hormones and mitochondrial modulators. To achieve our goals we use several experimental models such as isolated mitochondria, in vitro and in vivo models of disease and human samples. Moreira has published more than 200 scientific peer-reviewed articles. She is deputy editor of Journal of Alzheimer's Disease, associate editor of Journal of Alzheimer's Disease Reports and Frontiers of Aging Neuroscience, section editor of BBA-Molecular Basis of Disease and belongs to the editorial board of Antioxidants and Redox Signaling and Aging Brain. Paula Moreira won the Stimulus to Research prize, in 2003, supported by the Calouste Gulbenkian Foundation and, in 2008, the L¿Oréal for Women in Science Award supported by L'Oreal Portugal/UNESCO/ FCT.
Identification

Personal identification

Full name
Paula Isabel da Silva Moreira

Citation names

  • Moreira, Paula
  • Paula I. Moreira
  • Moreira, PI
  • Moreira, Paula Isabel

Author identifiers

Ciência ID
9C16-2F47-6D91
ORCID iD
0000-0001-5177-6747
AuthenticusID
R-000-E6F
Google Scholar ID
https://scholar.google.pt/citations?user=5JO6pzkAAAAJ&hl=pt-PT
Researcher Id
B-3608-2009
Scopus Author Id
56038291200

Email addresses

  • pismoreira@gmail.com (Professional)
  • pimoreira@fmed.uc.pt (Professional)
  • venta@ci.uc.pt (Professional)

Addresses

  • Pólo III, Pólo das Ciências da Saúde, 3000-548, Azinhaga de Santa Comba, Celas, Coimbra, Portugal (Professional)
  • Centro de Neurociências e Biologia Celular, Universidade de Coimbra, Rua Larga, Faculdade de Medicina, Pólo I, 1º andar, 3004-504, Coimbra, Coimbra, Portugal (Professional)

Websites

  • https://www.cnc.uc.pt/pt/people/p-moreira (Professional)
  • https://www.researchgate.net/profile/Paula_Moreira3 (Professional)
  • https://publons.com/researcher/999744/paula-i-moreira/ (Professional)

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Neurosciences

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Education
Degree Classification
2007/07/16
Concluded
Ciências Biomédicas (Doutoramento)
Major in Neurociências
Universidade de Coimbra - Faculdade de Medicina, Portugal
"Mitochondrial dysfunction in Alzheimer's disease and diabetes : effect of compounds with antioxidant properties" (THESIS/DISSERTATION)
Aprovado com Distinção e Louvor, por unanimidade
2002/05/23
Concluded
Biologia Celular (Mestrado)
Major in Não Aplicável
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Effect of Aß25-35 in the mitochondrial permeability transition pore: a comparative study " (THESIS/DISSERTATION)
1998/07/09
Concluded
Biologia (Licenciatura)
Major in Ramo Científico
Universidade de Coimbra - Faculdade de Ciências e Tecnologia, Portugal
Affiliation

Science

Category
Host institution
Employer
2007 - Current Researcher (Research) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Teaching in Higher Education

Category
Host institution
Employer
2016 - Current Assistant Professor (University Teacher) Universidade de Coimbra - Faculdade de Medicina, Portugal
Universidade de Coimbra - Faculdade de Medicina, Portugal
2014 - 2015 Invited Assistant Professor (University Teacher) University of Texas at San Antonio, United States
University of Texas at San Antonio College of Sciences, United States
2011 - 2015 Invited Assistant Professor (University Teacher) Universidade de Coimbra - Faculdade de Medicina, Portugal
Universidade de Coimbra - Faculdade de Medicina, Portugal
2005 - 2011 Assistant (University Teacher) Universidade de Coimbra - Faculdade de Medicina, Portugal
Universidade de Coimbra - Faculdade de Medicina, Portugal
Projects

Grant

Designation Funders
2022 - Current Zfra 1-31: an early intervention in T2D-associated neurodegeneration
EXPL/MED-FSL/0033/2021
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia, I.P. (Lisbon, Portugal)
Ongoing
2020 - Current Lipidomic fingerprint of MAMs in Alzheimer's disease - impact of its modulation on neuronal metabolism
SFRH/BD/148801/2019
Supervisor
Universidade de Coimbra - Faculdade de Medicina, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia, I.P. (Lisbon, Portugal)
Ongoing
2019 - Current Rational Drug Design of novel potent multifunctional agents for Alzheimer’s Disease treatment
SFRH/BD/138460/2018
Supervisor
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Coimbra Faculdade de Farmácia, Portugal
Fundação para a Ciência e a Tecnologia, I.P. (Lisbon, Portugal)
Ongoing
2022 - 2023 An exploratory study of the gender-specific response to hypoxia in Alzheimer's disease
ERG 2022
Supervisor
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Ongoing
2021 - 2022 Zfra 1-31 peptide as a new candidate to fight type 2 diabetes-associated brain damage: a pilot study
ERG 2021
Supervisor
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Ongoing
2016 - 2019/03/31 Exploring the crosstalk of neuronal WWOX and mitochondria in type 2 diabetes-associated neurodegeneration
SFRH/BPD/107741/2015
Supervisor
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia, I.P. (Lisbon, Portugal)
Concluded
2016 - 2019/01/31 Unveiling the potential of HIF-1a as a biomarker and therapeutic target in Alzheimer’s disease
SFRH/BPD/109822/2015
Supervisor
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia, I.P. (Lisbon, Portugal)
Concluded
2017 - 2019 Unravelling the neuroprotective role of peripheral co-administration of liraglutide and ghrelin on brain and cognitive function in Huntington disease
SFRH/BPD/84473/2012
Supervisor
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Concluded
2015 - 2018 Does habitual physical activity mitigates chemotherapy-induced cardiac and brain dysfunction in a mouse model of prostate cancer? Role of mitochondrial-mediated mechanisms
SFRH/BPD/108322/2015
Supervisor
Universidade do Porto Centro de Investigação em Actividade Física Saúde e Lazer, Portugal
Concluded
2015 - 2018 HDAC3 neurophysiology and drug targeting in neurodegeneration
SFRH/BPD/102259/2014
Supervisor
Universidade do Porto Faculdade de Farmácia, Portugal
Fundação para a Ciência e a Tecnologia, I.P.
Concluded
2014 - 2017 Mild mitochondrial uncoupling: exploring its protective effects against brain damage associated to insulin-induced hypoglycemic events in type 1 diabetes
SFRH/BPD/95770/2013
Supervisor
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Coimbra - Faculdade de Ciências e Tecnologia, Portugal
Fundação para a Ciência e a Tecnologia, I.P. (Lisbon, Portugal)

Fundação para a Ciência e a Tecnologia, I.P.
Concluded
2013 - 2016/06/30 Mitochondrial trafficking in Alzheimer’s disease and hypoxic preconditioning: unveiling the role of the hypoxia up-regulated mitochondrial movement regulator
SFRH/BPD/84163/2012
Supervisor
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia, I.P. (Lisbon, Portugal)
Concluded
2013 - 2016 IMPACT OF PERIPHERAL EXENDIN-4 THERAPY ON THE MOLECULAR MECHANISMS UNDERLYING DIFFERENTIAL GENDER-RELATED BRAIN FUNCTION IN LONG-TERM TYPE 2 DIABETES
SFRH/BPD/84473/2012
Supervisor
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia, I.P. (Lisbon, Portugal)
Concluded
2009 - 2013/02 Diabetes-associated endothelium dysfunction: a cause of neurodegeneration? The role of brain endothelial mitochondria
SFRH/BD/43965/2008
Supervisor
Universidade de Coimbra - Faculdade de Ciências e Tecnologia, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia, I.P. (Lisbon, Portugal)
Concluded
2009 - 2012/12/31 DECIPHERING THE ROLE OF MITOCHONDRIA AND UNCOUPLING PROTEINS IN HYPOGLYCEMIA- AND/OR HYPERGLYCEMIA-INDUCED BRAIN INJURY
SFRH/BD/43968/2008
Supervisor
Universidade de Coimbra - Faculdade de Ciências e Tecnologia, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia, I.P. (Lisbon, Portugal)
Concluded
2008 - 2012/02/29 ROLE OF MITOCHONDRIA IN THE REGULATION OF THE TRANSCRIPTION FACTOR HYPOXIA-INDUCIBLE FACTOR-1 IN BRAIN ENDOTHELIUM: POTENTIAL PROTECTION AGAINST DIABETIC COMPLICATIONS
SFRH/BD/40702/2007
Supervisor
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Concluded
2007 - 2010 Impact of aging and gender in diabetic brain metabolism, oxidative stress and inflammation: Is there a (protective) role for insulin therapy?
SFRH/BPD/26872/2006
Supervisor
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Concluded
2002 - 2006 Mitocôndria e sua relação com o envelhecimento, a doença de Alzheimer e a diabetes: papel da proteína b-amilóide
SFRH/BD/5320/2001
PhD Student Fellow
Fundação para a Ciência e a Tecnologia, Portugal
Fundação para a Ciência e a Tecnologia
2000 - 2002 Efeito do peptídeo beta-amilóide no poro de permeabilidade transitória da mitocôndria
PRAXIS XXI/BM/20952/1999
Master Student Fellow
Universidade de Coimbra - Faculdade de Ciências e Tecnologia, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia, I.P. (Lisbon, Portugal)
Concluded

Contract

Designation Funders
2020 - 2026/12/31 Multidisciplinary Institute of Ageing (MIA) - Portugal
info:eu-repo/grantAgreement/EC/H2020/857524/EU
Researcher
European Commission
Ongoing
2019 - 2021/07 A Saúde no Saber
45-2019/478
Researcher
Ciência Viva, Portugal
Ongoing
2018 - 2021 The ups and downs of cellular stress: the “MAM hypothesis” for Bipolar disorder pathophysiology
CENTRO-01-0145-FEDER-028214
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Ongoing
2017 - 2020 HealthyAging2020
HealthyAging2020 CENTRO-01-0145-FEDER-000012-N2323
Researcher
Comissão de Coordenação e Desenvolvimento Regional do Centro
2016 - 2019/12/31 Tratamento do cancro e da doença de Alzheimer: à descoberta de novos fármacos
SII&DT 3269 Drugs2CAD
Researcher
Universidade de Coimbra, Portugal
Agência Nacional de Inovação, S.A.
Concluded
2018 - 2019 Brain protection by Evolocumab in individuals at high risk for cardiovascular disease: from bench to bedside
PEPITA2018
Principal investigator
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Universidade de Coimbra - Faculdade de Medicina
Concluded
2016 - 2018 Targeting huntingtin proteostasis and mitochondria to prevent neuronal dysfunction in Huntington's disease
PTDC/NEU-NMC/0412/2014
Researcher
Fundação para a Ciência e a Tecnologia, I.P. (Lisbon, Portugal)
2016 - 2018 The changing brain in Alzheimer's disease: is the retina a reliable mirror of disease onset and progression?
Prémio Mantero Belard 2015
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Concluded
2014 - 2015/02 Ageing@Coimbra: A Co-location Centre in the European Knowledge and Innovation Network for Active and Healthy Ageing
Researcher
Fundação para a Ciência e a Tecnologia, I.P.
Concluded
2014 - 2015 Selenate and Reduction of Neurofibrillary Tangle Formation: Role of Selenoproteins
U54MD008149
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
National Institute on Minority Health and Health Disparities
Concluded
2013 - 2015 Mitochondrial Trafficking In Alzheimer Disease: Revealing the Role of HUMMR
NIRG-13-282387
Principal investigator
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Alzheimer's Association
2013 - 2015 New Strategies to Manage Brain Diseases
CENTRO-07-ST24-FEDER-002002
Researcher
Programa Operacional Regional do Centro - Projecto Mais Centro
Concluded
2013 - 2014 Faulty cross-talk between endothelial cells and neurons in Alzheimer´s disease brain. Does endoplasmic reticulum stress play a role?
MOREIRA06JAN13
Principal investigator
Faculty of Medicine, University of Coimbra
2010 - 2013/09 Can Phytoestrogens be Safe and Effective Food Additives for Women During Menopause? - An In Vitro and In Vivo Approach to the problem.
Researcher
Fundação para a Ciência e a Tecnologia, I.P.
2011 - 2013/08 Mitochondrial preconditioning: potential neuroprotective effect in Alzheimer's disease
Principal investigator
Fundação para a Ciência e a Tecnologia, I.P.
2010 - 2013/03 The pathological interaction between diabetes and Alzheimer's disease: exploring the role of brain endothelial mitochondria and uncoupling proteins
Principal investigator
Fundação para a Ciência e a Tecnologia, I.P.
2008 - 2012/03 A new route for endothelial dysfunction on diabetes: From phenotypes to molecules
Researcher
Fundação para a Ciência e a Tecnologia, I.P.
2011 - 2012 Influence of gender on the molecular mechanisms underlying aging-related changes in diabetic brain: the impact of insulin therapy
PMADSC
Principal investigator
Faculty of Medicine, University of Coimbra
2008 - 2010 Towards novel inhibitors of Alzheimer’s disease-associated beta-amyloid aggregation and toxicity: from statins as potential leads to the design of effective drugs
III-45
Principal investigator
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
Institute for Interdisciplinary Research, University of Coimbra
Concluded
2008 - 2009 Da diabetes à demência: Explorando as vias de sinalização mediadas pela mitocôndria e suas proteínas desacopladoras
----
Principal investigator
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Concluded
2007 - 2009 Exploring the crosstalk between mitochondrial reactive oxygen species and the transcriptional factor hypoxia factor-1 in brain and retinal endothelium
------
Principal investigator
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
European Foundation for the Study of Diabetes
Concluded
Outputs

Publications

Book
  1. Moreira, PI. Alzheimer's Disease: New Beginnings. Netherlands: IOS Press BV. 2018.
    Published • Editor
Book chapter
  1. Carvalho, Cristina; Pires, Joana F.; Moreira, Paula I.; Raimundo, Nuno. "Disrupted cellular quality control mechanisms in aging". In Aging, 359-384. Elsevier, 2023.
    10.1016/b978-0-12-823761-8.00016-1
  2. Cardoso, Susana; Moreira, Paula I.. Corresponding author: Moreira, Paula I.. "Targeting Mitochondria and Redox Dyshomeostasis in Brain Ageing: An Update". In Redox Signaling and Biomarkers in Ageing, 147-183. Springer International Publishing, 2022.
    Published • 10.1007/978-3-030-84965-8_8
  3. Moreira, PI; Sónia C. Correia. "Unraveling the Role of Mitochondria in Alzheimer's Disease". In Vascular Disease, Alzheimer's Disease, and Mild Cognitive Impairment: Advancing an Integrated Approach, 407. Oxford, United States: Oxford University Press, USA, 2020.
    Published
  4. Cardoso, Susana; Moreira, Paula I.. "Antidiabetic drugs for Alzheimer's and Parkinson's diseases: Repurposing insulin, metformin, and thiazolidinediones". In Metabolic and Bioenergetic Drivers of Neurodegenerative Disease: Treating neurodegenerative diseases as metabolic diseases, 37-64. Elsevier, 2020.
    Published • 10.1016/bs.irn.2020.02.010
  5. Carvalho, Cristina; Moreira, Paula I.. "Cognitive Impairment in Obesity and Diabetes". In Obesity and Diabetes, 399-414. Springer International Publishing, 2020.
    10.1007/978-3-030-53370-0_29
  6. Ferreira, Hugo; Martins, João; Nunes, Ana; Moreira, Paula I.; Castelo-Branco, Miguel; Ambrósio, António Francisco; Serranho, Pedro; Bernardes, Rui. "Characterization of the Retinal Changes of the 3xTg-AD Mouse Model of Alzheimer's Disease". In XV Mediterranean Conference on Medical and Biological Engineering and Computing – MEDICON 2019, 1816-1821. Springer International Publishing, 2019.
    10.1007/978-3-030-31635-8_220
  7. Correia, S.C.; Moreira, P.I.. "Role of mitochondria in neurodegenerative diseases: The dark side of the "Energy factory"". 2018.
  8. Cardoso, S.M.; Correia, S.C.; Carvalho, C.; Moreira, P.I.. "Mitochondria in Alzheimer’s disease and diabetes-associated neurodegeneration: License to heal!". 2017.
    10.1007/164_2017_3
  9. Cardoso, S.; Seiça, R.; Moreira, P.I.. "Diabesity and brain energy metabolism: The case of alzheimer’s disease". 2017.
    10.1007/978-3-319-63260-5_5
  10. Castellani, R.J.; Correia, S.C.; Moreira, P.I.; Perry, G.. "Tackling Alzheimer's Disease by Targeting Oxidative Stress and Mitochondria". 2016.
    10.1016/B978-0-12-802173-6.00018-6
  11. Correia, S.C.; Moreira, P.I.; Perry, G.. "Autophagy in alzheimer’s disease: A cleaning service out-of-order?". 2015.
    10.1007/978-3-319-13939-5_7
  12. Marques-Aleixo, I.; Santos-Alves, E.; Moreira, P.I.; Oliveira, P.J.; Magalhães, J.; Ascensão, A.. "Exercise-Induced Protection Against Aging and Neurodegenerative Diseases: Role of Redox- and Mitochondrial-Based Alterations". 2015.
    10.1002/9781118840634.ch26
  13. Nunes, A.R.; Alves, M.G.; Moreira, P.I.; Oliveira, P.F.; Silva, B.M.. "Impact of green tea (Camellia Sinensis L.) consumption in diabetes mellitus-induced neurodegeneration". 2015.
  14. Castellani, R.J.; Zhu, X.; Perry, G.; Moreira, P.I.. "Alzheimer's Disease: An Overview". 2014.
    10.1016/B978-0-12-801238-3.04491-3
  15. Castellani, R.J.; Moreira, P.I.; Zhu, X.; Perry, G.. "Alzheimer's Disease: Pathology and Pathogenesis". 2014.
    10.1016/B978-0-12-801238-3.00160-4
  16. Santos, R.X.; Moreira, P.I.. "Mtor is a potential therapeutic target for alzheimer's disease". 2014.
  17. Carvalho, C.; Santos, R.X.; Cardoso, S.; Correia, S.C.; Moreira, P.I.. "Chronic hypoxia, type 2 diabetes and Alzheimer's disease: A dangerous triad". 2013.
  18. Duarte, A.; Candeias, E.; Correia, S.C.; Santos, R.X.; Carvalho, C.; Cardoso, S.; Plácido, A.I.; et al. "The Janus Face of Insulin in Brain". 2013.
    10.1002/9781118395318.ch5
  19. Cardoso, S.; Carvalho, C.; Correia, S.; Santos, R.X.; Santos, M.S.; Moreira, P.I.. "Mitochondrial uncoupling proteins - therapeutic targets in neurodegeneration?". 2011.
  20. Carvalho, C.; Correia, S.C.; Santos, R.X.; Cardoso, S.; Santos, M.S.; Moreira, P.I.. "Diabetes, mitochondria and brain endothelium dysfunction: A dangerous triad for neurodegeneration?". 2011.
  21. Nunomura, A.; Takeda, A.; Moreira, P.I.; Castellani, R.J.; Lee, H.-G.; Zhu, X.; Smith, M.A.; Perry, G.. "Neurofibrillary tangle formation as a protective response to oxidative stress in Alzheimer's disease". 2009.
    10.1007/978-0-387-87995-6_9
  22. Moreira, P.I.; Smith, M.A.; Zhu, X.; Nunomura, A.; Perry, G.. "The potential application of antioxidant agents in Alzheimer disease therapeutics". In Ageing research reviews. 2007.
    10.1007/978-0-387-71522-3_12
Conference abstract
  1. C Carvalho, SC Correia, S Cardoso, PI Moreira. Untangling the protective role of Zfra 1-31 peptide against type 2 diabet. "Untangling the protective role of Zfra 1-31 peptide against type 2 diabetes-associated brain damage: preliminary results of a pilot study". Paper presented in 56th Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI), Bari, 2022.
    Published
  2. Moreira, PI; Carvalho, Cristina. "Neuroprotective effects of Zfra 1-31 peptide against high glucose-induced mitochondrial and autophagy defects". Paper presented in 57th Annual Meeting of the European Association for the Study of Diabetes 2021 - EASD2021, 2021.
    Published
  3. Cardoso, Susana; Diano, Sabrina; Moreira, PI. "UCP2 inhibition modulates cognition and brain mitochondrial function under different metabolic insults.". Paper presented in 55th Annual Scientific Meeting of the European Society for Clinical Investigation - ESCI2021, 2021.
    Published
  4. T Fernandes; R Resende; MR Domingues; Moreira, PI; C Pereira. "Physical and biochemical alterations in endoplasmic reticulum-mitochondria contacts in an Alzheimer's disease in vitro model". Paper presented in 55th Annual Scientific Meeting of the European Society for Clinical Investigation - ESCI2021, 2021.
    Published
  5. D Mena; IN Alves; DF Silva; E Candeias; CR Oliveira,; R Seiça; PF Monteiro; Moreira, PI; AI Duarte. "The Neuroprotection by GLP-1 Receptor Agonists in High Cardiovascular risk and Neurodegenerative Diseases". Paper presented in 55th Annual Scientific Meeting of the European Society for Clinical Investigation - ESCI2021, 2021.
    Published
  6. S Correia; M Alves; P Oliveira; G Casadesus; G Perry; Moreira, PI. "Hypoxia preconditioning-triggered mitochondrial remodeling in a rat model of sporadic Alzheimer's disease: A" breath of fresh air" towards effective treatment?". Paper presented in 55th Annual Scientific Meeting of the European Society for Clinical Investigation - ESCI2021, 2021.
    Published
  7. Moreira, PI; C Carvalho. "WWOX inhibition in neuronal cells exposed to high glucose ameliorates mitochondrial dynamics and autophagy preventing cell death". Paper presented in 55th Annual Scientific Meeting of the European Society for Clinical Investigation - ESCI2021, 2021.
    Published
  8. C Carvalho; C Martin; Moreira, PI. "N epsilon-Carboxymethyl lysine induces mitochondrial-associated defects in differentiated SH-SY5Y neuroblastoma cells". Paper presented in 55th Annual Scientific Meeting of the European Society for Clinical Investigation - ESCI2021, 2021.
    Published
  9. D Franco da Silva; MI Alves; D Mena; D Vaz; PF Monteiro; Moreira, PI; AI Duarte. "The neuroprotective effects of peripheral treatment with Evolocumab in middle-aged rat at high cardiovascular risk". Paper presented in European Society for Clinical Investigation (ESCI) 2020: Utrecht, NL, Utrecht, 2020.
    Published
  10. D Mena; MI Alves; DF Silva; D Vaz; E Candeias; CR Oliveira; PF Monteiro; Moreira, PI; AI Duarte. "Diet-induced high cardiovascular risk compromises brain hippocampal metabolism and long-term spatial memory in middle-aged male rats". Paper presented in 53rd Annual Meeting of the European Society for Clinical Investigation, Utrecht, 2020.
    Published
  11. D Mena; MI Alves; M Sjogren; DF Silva; CR Oliveira; Moreira, PI; M Bjorkqvist; AI Duarte. "Co-administration of liraglutide and ghrelin ameliorates brain mitochondrial energy metabolism in the R6/2 mouse model for Huntington's disease". Paper presented in 53rd Annual Meeting of the European Society for Clinical Investigation, Utrecht, 2020.
    Published
  12. MI Alves; D Mena; DF Silva; R Seica; CR Oliveira; AI Duarte; Moreira, PI. "Type 2 diabetes mitigates brain cortical energy metabolism in middle-aged female rats". Paper presented in 53rd Annual Meeting of the European Society for Clinical Investigation, Utrecht, 2020.
    Published
Conference poster
  1. Moreira, PI. "Retinal thinning of inner layers is associated with visual cortex atrophy in a mouse model of Alzheimer's disease: a longitudinal in vivo multimodal study". Paper presented in ARVO Annual Meeting, 2019.
Journal article
  1. Cristina Carvalho; Sónia C. Correia; Raquel Seiça; Paula I. Moreira. "WWOX inhibition by Zfra1-31 restores mitochondrial homeostasis and viability of neuronal cells exposed to high glucose". Cellular and Molecular Life Sciences (2022): https://doi.org/10.1007/s00018-022-04508-7.
    10.1007/s00018-022-04508-7
  2. Antónia Diniz; Marco G. Alves; Emanuel Candeias; Ana I. Duarte; Paula I. Moreira; Branca M. Silva; Pedro F. Oliveira; Luís Rato. "Type 2 Diabetes Induces a Pro-Oxidative Environment in Rat Epididymis by Disrupting SIRT1/PGC-1a/SIRT3 Pathway". International Journal of Molecular Sciences (2022): https://doi.org/10.3390/ijms23168912.
    10.3390/ijms23168912
  3. Guimarães, Pedro; Serranho, Pedro; Martins, João; Moreira, Paula I.; Ambrósio, António Francisco; Castelo-Branco, Miguel; Bernardes, Rui. "Retinal Aging in 3× Tg-AD Mice Model of Alzheimer's Disease". Frontiers in Aging Neuroscience 14 (2022): http://dx.doi.org/10.3389/fnagi.2022.832195.
    10.3389/fnagi.2022.832195
  4. Pereira, Ana Catarina; De Pascale, Jessica; Resende, Rosa; Cardoso, Susana; Ferreira, Isabel; Neves, Bruno Miguel; Carrascal, Mylène A.; et al. "ER-mitochondria communication is involved in NLRP3 inflammasome activation under stress conditions in the innate immune system". Cellular and Molecular Life Sciences 79 4 (2022): http://dx.doi.org/10.1007/s00018-022-04211-7.
    10.1007/s00018-022-04211-7
  5. Correia, Sónia C.; Alves, Marco G.; Oliveira, Pedro F.; Casadesus, Gemma; LaManna, Joseph; Perry, George; Moreira, Paula I.. "Hypoxic preconditioning averts sporadic Alzheimer’s disease-like phenotype in rats: a focus on mitochondria". Antioxidants & Redox Signaling (2022): http://dx.doi.org/10.1089/ars.2019.8007.
    10.1089/ars.2019.8007
  6. Susana Cardoso; Paula I. Moreira. "Insulin-Induced Recurrent Hypoglycemia Up-Regulates Glucose Metabolism in the Brain Cortex of Chemically Induced Diabetic Rats". International Journal of Molecular Sciences (2021): https://doi.org/10.3390/ijms222413470.
    10.3390/ijms222413470
  7. Sónia C. Correia; Paula I. Moreira. "Oxygen Sensing and Signaling in Alzheimer's Disease: A Breathtaking Story!". Cellular and Molecular Neurobiology (2021): https://doi.org/10.1007/s10571-021-01148-6.
    10.1007/s10571-021-01148-6
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    10.1016/j.jalz.2006.03.001
  186. Moreira, P.I.; Honda, K.; Zhu, X.; Nunomura, A.; Casadesus, G.; Smith, M.A.; Perry, G.. "Brain and brawn: Parallels in oxidative strength". Neurology 66 2 SUPPL. 1 (2006): http://www.scopus.com/inward/record.url?eid=2-s2.0-33644850568&partnerID=MN8TOARS.
  187. Zhu, X.; Lee, H.-G.; Moreira, P.I.; Smith, M.A.; Perry, G.. "Presenilin mutation: A deadly first hit in Alzheimer disease - A commentary on "aging sensitizes towards ROS formation and lipid peroxidation in PS1M146L transgenic mice"". Free Radical Biology and Medicine 40 5 (2006): 737-739. http://www.scopus.com/inward/record.url?eid=2-s2.0-33644659794&partnerID=MN8TOARS.
    10.1016/j.freeradbiomed.2005.12.028
  188. Moreira, P.I.; Custódio, J.; Moreno, A.; Oliveira, C.R.; Santos, M.S.. "Tamoxifen and estradiol interact with the flavin mononucleotide site of complex I leading to mitochondrial failure". Journal of Biological Chemistry 281 15 (2006): 10143-10152. http://www.scopus.com/inward/record.url?eid=2-s2.0-33744518169&partnerID=MN8TOARS.
    10.1074/jbc.M510249200
  189. Moreira, P.I.; Rolo, A.P.; Sena, C.; Seiça, R.; Oliveira, C.R.; Santos, M.S.. "Insulin attenuates diabetes-related mitochondrial alterations: A comparative study". Medicinal Chemistry 2 3 (2006): 299-308. http://www.scopus.com/inward/record.url?eid=2-s2.0-33746153746&partnerID=MN8TOARS.
    10.2174/157340606776930754
  190. Moreira, P.I.; Cardoso, S.M.; Santos, M.S.; Oliveira, C.R.. "The key role of mitochondria in Alzheimer's disease". Journal of Alzheimer's Disease 9 2 (2006): 101-110. http://www.scopus.com/inward/record.url?eid=2-s2.0-33746066329&partnerID=MN8TOARS.
  191. Moreira, P.I.; Zhu, X.; Nunomura, A.; Smith, M.A.; Perry, G.. "Therapeutic options in Alzheimer's disease". Expert Review of Neurotherapeutics 6 6 (2006): 897-910. http://www.scopus.com/inward/record.url?eid=2-s2.0-33745486884&partnerID=MN8TOARS.
    10.1586/14737175.6.6.897
  192. Zhu, X.; Perry, G.; Moreira, P.I.; Aliev, G.; Cash, A.D.; Hirai, K.; Smith, M.A.. "Mitochondrial abnormalities and oxidative imbalance in Alzheimer disease". Journal of Alzheimer's Disease 9 2 (2006): 147-153. http://www.scopus.com/inward/record.url?eid=2-s2.0-33746089859&partnerID=MN8TOARS.
  193. Moreira, P.I.; Oliveira, C.. "Foreword: Mitochondria in Alzheimer disease". Journal of Alzheimer's Disease 9 2 (2006): http://www.scopus.com/inward/record.url?eid=2-s2.0-33746065622&partnerID=MN8TOARS.
  194. Moreira, P.I.; Zhu, X.; Liu, Q.; Honda, K.; Siedlak, S.L.; Harris, P.L.; Smith, M.A.; Perry, G.. "Compensatory responses induced by oxidative stress in Alzheimer disease". Biological Research 39 1 (2006): 7-13. http://www.scopus.com/inward/record.url?eid=2-s2.0-33745840777&partnerID=MN8TOARS.
  195. Honda, K.; Moreira, P.I.; Liu, Q.; Siedlak, S.L.; Zhu, X.; Smith, M.A.; Perry, G.. "Redox active iron at the center of oxidative stress in Alzheimer disease". Letters in Drug Design and Discovery 2 6 (2005): 479-482. http://www.scopus.com/inward/record.url?eid=2-s2.0-24744432930&partnerID=MN8TOARS.
    10.2174/1570180054771545
  196. Moreira, P.I.; Honda, K.; Liu, Q.; Santos, M.S.; Oliveira, C.R.; Aliev, G.; Nunomura, A.; et al. "Oxidative stress: The old enemy in Alzheimer's disease pathophysiology". Current Alzheimer Research 2 4 (2005): 403-408. http://www.scopus.com/inward/record.url?eid=2-s2.0-24644443839&partnerID=MN8TOARS.
    10.2174/156720505774330537
  197. Moreira, P.I.; Santos, M.S.; Sena, C.; Nunes, E.; Seiça, R.; Oliveira, C.R.. "CoQ10 therapy attenuates amyloid ß-peptide toxicity in brain mitochondria isolated from aged diabetic rats". Experimental Neurology 196 1 (2005): 112-119. http://www.scopus.com/inward/record.url?eid=2-s2.0-26244447857&partnerID=MN8TOARS.
    10.1016/j.expneurol.2005.07.012
  198. Sayre, L.M.; Moreira, P.I.; Smith, M.A.; Perry, G.. "Metal ions and oxidative protein modification in neurological disease". Annali dell'Istituto Superiore di Sanita 41 2 (2005): 143-164. http://www.scopus.com/inward/record.url?eid=2-s2.0-31644435822&partnerID=MN8TOARS.
  199. Pereira, C.; Agostinho, P.; Moreira, P.I.; Cardoso, S.M.; Oliveira, C.R.. "Alzheimer's disease-associated neurotoxic mechanisms and neuroprotective strategies". Current Drug Targets: CNS and Neurological Disorders 4 4 (2005): 383-403. http://www.scopus.com/inward/record.url?eid=2-s2.0-23144463734&partnerID=MN8TOARS.
    10.2174/1568007054546117
  200. Moreira, P.I.; Smith, M.A.; Zhu, X.; Nunomura, A.; Castellani, R.J.; Perry, G.. "Oxidative stress and neurodegeneration". Annals of the New York Academy of Sciences 1043 (2005): 545-552. http://www.scopus.com/inward/record.url?eid=2-s2.0-23744439419&partnerID=MN8TOARS.
    10.1196/annals.1333.062
  201. Petersen, R.B.; Siedlak, S.L.; Lee, H.-G.; Kim, Y.-S.; Nunomura, A.; Tagliavini, F.; Ghetti, B.; et al. "Redox metals and oxidative abnormalities in human prion diseases". Acta Neuropathologica 110 3 (2005): 232-238. http://www.scopus.com/inward/record.url?eid=2-s2.0-26444549058&partnerID=MN8TOARS.
    10.1007/s00401-005-1034-4
  202. Zhu, X.; Moreira, P.I.; Smith, M.A.; Perry, G.. "Alzheimer's disease: An intracellular movement disorder?". Trends in Molecular Medicine 11 9 (2005): 391-393. http://www.scopus.com/inward/record.url?eid=2-s2.0-24344483065&partnerID=MN8TOARS.
    10.1016/j.molmed.2005.07.002
  203. Marlatt, M.W.; Webber, K.M.; Moreira, P.I.; Lee, H.-G.; Casadesus, G.; Honda, K.; Zhu, X.; Perry, G.; Smith, M.A.. "Therapeutic opportunities in Alzheimer Disease: One for all or all for one?". Current Medicinal Chemistry 12 10 (2005): 1137-1147. http://www.scopus.com/inward/record.url?eid=2-s2.0-18544380930&partnerID=MN8TOARS.
    10.2174/0929867053764644
  204. Moreira, P.I.; Siedlak, S.L.; Aliev, G.; Zhu, X.; Cash, A.D.; Smith, M.A.; Perry, G.. "Oxidative stress mechanisms and potential therapeutics in Alzheimer disease". Journal of Neural Transmission 112 7 (2005): 921-932. http://www.scopus.com/inward/record.url?eid=2-s2.0-20944449836&partnerID=MN8TOARS.
    10.1007/s00702-004-0242-8
  205. Honda, K.; Smithi, M.A.; Zhu, X.; Baus, D.; Merrick, W.C.; Tartakoff, A.M.; Hattier, T.; et al. "Ribosomal RNA in Alzheimer disease is oxidized by bound redox-active iron". Journal of Biological Chemistry 280 22 (2005): 20978-20986. http://www.scopus.com/inward/record.url?eid=2-s2.0-20444383489&partnerID=MN8TOARS.
    10.1074/jbc.M500526200
  206. Cardoso, S.M.; Moreira, P.I.; Agostinho, P.; Pereira, C.; Oliveira, C.R.. "Neurodegenerative pathways in Parkinson's disease: Therapeutic strategies". Current Drug Targets: CNS and Neurological Disorders 4 4 (2005): 405-419. http://www.scopus.com/inward/record.url?eid=2-s2.0-23144431757&partnerID=MN8TOARS.
    10.2174/1568007054546072
  207. Lee, H.-G.; Perry, G.; Moreira, P.I.; Garrett, M.R.; Liu, Q.; Zhu, X.; Takeda, A.; Nunomura, A.; Smith, M.A.. "Tau phosphorylation in Alzheimer's disease: Pathogen or protector?". Trends in Molecular Medicine 11 4 (2005): 164-169. http://www.scopus.com/inward/record.url?eid=2-s2.0-17044435830&partnerID=MN8TOARS.
    10.1016/j.molmed.2005.02.008
  208. Moreira, P.I.; Santos, M.S.; Sena, C.; Seiça, R.; Oliveira, C.R.. "Insulin protects against amyloid ß-peptide toxicity in brain mitochondria of diabetic rats". Neurobiology of Disease 18 3 (2005): 628-637. http://www.scopus.com/inward/record.url?eid=2-s2.0-14744294296&partnerID=MN8TOARS.
    10.1016/j.nbd.2004.10.017
  209. Moreira, P.I.; Oliveira, C.R.; Santos, M.S.; Nunomura, A.; Honda, K.; Zhu, X.; Smith, M.A.; Perry, G.. "A second look into the oxidant mechanisms in Alzheimer's disease". Current Neurovascular Research 2 2 (2005): 179-184. http://www.scopus.com/inward/record.url?eid=2-s2.0-18744402471&partnerID=MN8TOARS.
    10.2174/1567202053586758
  210. Smith, M.A.; Nunomura, A.; Lee, H.-G.; Zhu, X.; Moreira, P.I.; Avila, J.; Perry, G.. "Chronological primacy of oxidative stress in Alzheimer disease". Neurobiology of Aging 26 5 (2005): 579-580. http://www.scopus.com/inward/record.url?eid=2-s2.0-13644249113&partnerID=MN8TOARS.
    10.1016/j.neurobiolaging.2004.09.021
  211. Webber, K.M.; Smith, M.A.; Lee, H.-G.; Harris, P.L.; Moreira, P.; Perry, G.; Zhu, X.. "Mitogen- and stress-activated protein kinase 1: Convergence of the ERK and p38 pathways in Alzheimer's disease". Journal of Neuroscience Research 79 4 (2005): 554-560. http://www.scopus.com/inward/record.url?eid=2-s2.0-14144250344&partnerID=MN8TOARS.
    10.1002/jnr.20380
  212. Moreira, P.I.; Custódio, J.B.; Oliveira, C.R.; Santos, M.S.. "Brain mitochondrial injury induced by oxidative stress-related events is prevented by tamoxifen". Neuropharmacology 48 3 (2005): 435-447. http://www.scopus.com/inward/record.url?eid=2-s2.0-13844275276&partnerID=MN8TOARS.
    10.1016/j.neuropharm.2004.10.012
  213. Moreira, P.I.; Honda, K.; Liu, Q.; Aliev, G.; Oliveira, C.R.; Santos, M.S.; Zhu, X.; Smith, M.A.; Perry, G.. "Alzheimer's disease and oxidative stress: The old problem remains unsolved". Current Medicinal Chemistry - Central Nervous System Agents 5 1 (2005): 51-62. http://www.scopus.com/inward/record.url?eid=2-s2.0-15344351142&partnerID=MN8TOARS.
  214. Liu, Q.; Smith, M.A.; Avilá, J.; DeBernardis, J.; Kansal, M.; Takeda, A.; Zhu, X.; et al. "Alzheimer-specific epitopes of tau represent lipid peroxidation-induced conformations". Free Radical Biology and Medicine 38 6 (2005): 746-754. http://www.scopus.com/inward/record.url?eid=2-s2.0-13844267510&partnerID=MN8TOARS.
    10.1016/j.freeradbiomed.2004.11.005
  215. Moreira, P.I.; Smith, M.A.; Zhu, X.; Honda, K.; Lee, H.-G.; Aliev, G.; Perry, G.. "Oxidative damage and Alzheimer's disease: Are antioxidant therapies useful?". Drug News and Perspectives 18 1 (2005): 13-19. http://www.scopus.com/inward/record.url?eid=2-s2.0-17444377148&partnerID=MN8TOARS.
    10.1358/dnp.2005.18.1.877165
  216. Lee, H.-G.; Moreira, P.I.; Zhu, X.; Smith, M.A.; Perry, G.. "Staying connected: Synapses in alzheimer disease". American Journal of Pathology 165 5 (2004): 1461-1464. http://www.scopus.com/inward/record.url?eid=2-s2.0-7244252913&partnerID=MN8TOARS.
  217. Moreira, P.I.; Smith, M.A.; Zhu, X.; Santos, M.S.; Oliveira, C.R.; Perry, G.. "Therapeutic potential of oxidant mechanisms in Alzheimer's disease". Expert Review of Neurotherapeutics 4 6 (2004): 995-1004. http://www.scopus.com/inward/record.url?eid=2-s2.0-8344235899&partnerID=MN8TOARS.
    10.1586/14737175.4.6.995
  218. Liu, Q.; Xie, F.; Siedlak, S.L.; Nunomura, A.; Honda, K.; Moreira, P.I.; Zhua, X.; Smith, M.A.; Perry, G.. "Neurofilament proteins in neurodegenerative diseases". Cellular and Molecular Life Sciences 61 24 (2004): 3057-3075. http://www.scopus.com/inward/record.url?eid=2-s2.0-12144265815&partnerID=MN8TOARS.
    10.1007/s00018-004-4268-8
  219. Moreira, P.I.; Santos, M.S.; Moreno, A.M.; Proença, T.; Seiça, R.; de Oliveira, C.R.. "Effect of streptozotocin-induced diabetes on rat brain mitochondria". Journal of Neuroendocrinology 16 1 (2004): 32-38. http://www.scopus.com/inward/record.url?eid=2-s2.0-0742324515&partnerID=MN8TOARS.
    10.1111/j.1365-2826.2004.01107.x
  220. Moreira, P.I.; Custódio, J.B.; Oliveira, C.R.; Santos, M.S.. "Hydroxytamoxifen protects against oxidative stress in brain mitochondria". Biochemical Pharmacology 68 1 (2004): 195-204. http://www.scopus.com/inward/record.url?eid=2-s2.0-2942568021&partnerID=MN8TOARS.
    10.1016/j.bcp.2004.03.019
  221. Moreira, P.I.; Santos, M.S.; Moreno, A.M.; Seiça, R.; Oliveira, C.R.. "Increased vulnerability of brain mitochondria in diabetic (goto-kakizaki) rats with aging and amyloid-ß exposure". Diabetes 52 6 (2003): 1449-1456. http://www.scopus.com/inward/record.url?eid=2-s2.0-0038321341&partnerID=MN8TOARS.
    10.2337/diabetes.52.6.1449
  222. Pereira, C.; Agostinho, P.; Moreira, P.I.; Duarte, A.I.; Santos, M.S.; Oliveira, C.R.. "Neuroprotection strategies: Effect of vinpocetinein in vitro oxidative stress models | Estratégias de neuroprotecção: Efeito da vimpocetina em modelos in vitro de stresse oxidativo". Acta Medica Portuguesa 16 6 (2003): 401-406. http://www.scopus.com/inward/record.url?eid=2-s2.0-9644310235&partnerID=MN8TOARS.
  223. Moreira, P.I.; Santos, M.S.; Moreno, A.; Rego, A.C.; Oliveira, C.. "Effect of amyloid ß-peptide on permeability transition pore: A comparative study". Journal of Neuroscience Research 69 2 (2002): 257-267. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037100213&partnerID=MN8TOARS.
    10.1002/jnr.10282
  224. Moreira, P.I.; Santos, M.S.; Moreno, A.; Oliveira, C.. "Amyloid ß-peptide promotes permeability transition pore in brain mitochondria". Bioscience Reports 21 6 (2001): 789-800. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035780141&partnerID=MN8TOARS.
    10.1023/A:1015536808304
  225. Santos, M.S.; Duarte, A.I.; Moreira, P.I.; Oliveira, C.R.. "Synaptosomal response to oxidative stress: Effect of vinpocetine". Free Radical Research 32 1 (2000): 57-66. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033988559&partnerID=MN8TOARS.
  226. Moreira, P.; Pereira, C.; Santos, M.S.; Oliveira, C.. "Effect of zinc ions on the cytotoxicity induced by the amyloid ß- peptide". Antioxidants and Redox Signaling 2 2 (2000): 317-325. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033949740&partnerID=MN8TOARS.
  227. Pereira, C.; Moreira, P.; Seiça, R.; Santos, M.S.; Oliveira, C.R.. "Susceptibility to ß-amyloid-induced toxicity is decreased in Goto- Kakizaki diabetic rats: Involvement of oxidative stress". Experimental Neurology 161 1 (2000): 383-391. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034051172&partnerID=MN8TOARS.
    10.1006/exnr.1999.7270
Journal issue
  1. Moreira, PI; George Perry; Jesus Avila; Aaron Serensen; Massimo Tabaton. "Preface: Alzheimer's Disease: New Beginnings". Journal of Alzheimer s Disease 64 1 (2018): https://content.iospress.com/journals/journal-of-alzheimers-disease/64/s1.
    Published • 10.1111/nyas.1982.396.issue-1
  2. Moreira, P.I.. "Mini-Symposium: Energy Demand and Energy Supply in Alzheimer’s Disease - Introduction". Brain Pathology 26 5 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84988637950&partnerID=MN8TOARS.
    10.1111/bpa.12398
Thesis / Dissertation
  1. Moreira, PI. "Mitochondrial dysfunction in Alzheimer's disease and diabetes : effect of compounds with antioxidant properties". PhD, Universidade de Coimbra Faculdade de Medicina, 2007. http://hdl.handle.net/10316/7501.
  2. Moreira, PI. "Effect of the amyloid beta peptide on the permeability transition pore: a comparative study". Master, Universidade de Coimbra - Faculdade de Ciências e Tecnologia, 2002.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2022/07/18 Metabolic Defects in Alzheimer's Disease International Research Conference on Neurodegenerative Diseases
Global Association for the Study of Neurodegenerative Diseases (Omaha, United States)
2022/05/25 Diabetes and Alzheimer's disease crosstalk Nova Medical School Seminars
Faculdade de Ciências Médicas, Universidade Nova de Lisboa (Lisboa, Portugal)
2022/04/22 Impaired insulin and IGF-1 signaling affects brain mitochondria and redox homeostasis Spanish Symposium on IGFs and Insulin 2022: Implications in Physiology and Disease
(Logroño, Spain)
2021/07/02 Alzheimer disease beyond amyloid: a preclinical perspective 35ª REUNIÃO ANUAL DO GEECD - Inovação em Doença de Alzheimer
GEECD - Grupo de Estudos em Envelhecimento Cerebral e Demência (Coimbra, Portugal)
2021/04/26 Mitochondrial dysfunction and oxidative stress in Alzheimer's disease Redox Webinar Series - Crosstalk between oxidative stress and metabolic defects: implications for Alzheimer's disease
Faculty of Pharmacy and Medicine, Sapienza University of Rome (Rome, Italy)
2019/05 Hypoxic preconditioning: a strategy to fight Alzheimer’s disease?
European Society of Clinical Investigation (Coimbra, Portugal)
2018/03 Mitochondrial dysfunction and energy failure in Alzheimer’s disease Focused Symposium “Bioenergetics and neurodegenerative disorders: moving from pathogenesis to therapeutics”; Advances in Neuroscience for Medical Advance
Centre for Therapeutic Innovation in Neuropsychiatry, Institut de Recherches Servier (France)
2016/06/04 Alzheimer's disease: mechanistic insights and biomarkers discovery 30ª Reunião do Grupo de Estudos de Envelhecimento Cerebral e Demência
(Lisboa, Portugal)
2016 Alzheimer's disease: focus on mitochondria Seminars_IBILI
(Coimbra, Portugal)
2015/10 The efficacy of the antidiabetic drug liraglutide in Alzheimer’s disease-like pathology 6th Annual Alliance for Healthy Ageing: Interventions to Slow Down Aging
(Newcastle, United Kingdom)
2015/03 Insulin signaling as a bridge between diabetes and Alzheimer’s disease Gordon Research Conference - IGF & Insulin System in Physiology & Disease
(California, United States)
2014/07 Mitochondria take center stage in Alzheimer’s disease 18th European BioEnergetics Conference – EBEC 2104
(Lisboa, Portugal)
2014/04 Etiologia e fisiopatologia das doenças neurodegenerativas Ciclo de Palestras em Atividade Física e Saúde “Exercício, Saúde e Sociedade
CIAFEL - Universidade do Porto (Porto, Portugal)
2014 A diabetes tipo 2 e a doença de Alzheimer Jornadas de Análises Clínicas e Saúde Pública – Reunião Anual 2014
Escola Superior de Tecnologia da Saúde de Coimbra (Coimbra, Portugal)
2013 Mitochondrial crossroad in Alzheimer’s disease 47th Annual Scientific Meeting of the European Society for Clinical Investigation
(Albufeira, Portugal)
2011 Mitochondria and the Vasculature 7th International Congress on Vascular Dementia
(Riga, Latvia)
2010/11/22 Alzheimer’s disease: research tools and therapeutic perspectives Palestras do Núcleo de Estudantes de Bioquímica
Núcleo de Estudantes de Bioquímica (Coimbra, Portugal)
2010/05/03 Mitochondria, diabetes and Alzheimer’s disease Seminars on neuropharmacology and functional imaging II: integrating mitochondria, diabetes and neurodegeneration
Universidade do Porto (Porto, Portugal)
2009/07 A disfunção mitocondrial na doença de Alzheimer II Jornadas de Bioquímica da UTAD
Universidade de Trás-os-Montes e Alto Douro (Vila Real, Portugal)
2008/07 A mitocôndria, um catalizador do envelhecimento cerebral e da demência Ciência 2008 – Encontro com a Ciência em Portugal Promovido pelos Laboratórios Associados
Fundação Calouste Gulbenkian (Lisboa, Portugal)
2007/11/08 Diabetes is a risk factor for Alzheimer disease: the role of mitochondria 5th International Congress on Vascular Dementia
(Budapeste, Hungary)
2007/11 O papel da mitocôndria na doença de Alzheimer 1º Congresso Científico de Saúde: Doenças Neurodegenerativas
Faculdade de Farmácia da Universidade de Lisboa (Lisboa, Portugal)
2007/04/28 Liver mitochondria isolated from ovariectomized and tamoxifen-treated ovariectomized rat females are affected by estradiol 1st Iberic Meeting on Medicinal Chemistry: Anticancer Agents – 1IMMC
(Régua, Portugal)
2006/12/08 Tamoxifen and estradiol: a deadly combination for cancer cells XV National Congress of Biochemistry
Sociedade Portuguesa de Bioquímica (Aveiro, Portugal)
2006/07 Mitochondrial autophagocytosis in Alzheimer disease 10th International Conference on Alzheimer´s Disease and Related Disorders
(Madrid, Spain)
2006/03 Tamoxifen and estradiol lead to mitochondrial complex I failure International Courses on Toxicology “Smart Toxicology: Subcellular Targets of Anti-Cancer Therapy”
Universidade de Coimbra, Centro de Neurociencias e Biologia Celular
2006 Oxidative Stress in Alzheimer disease: role of antioxidants 4th International Congress on the Improvement of the Quality of Life in Dementia, Epilepsy, MS and Peripheral Neuropathies
(Odessa, Ukraine)
2005/10 Brain mitochondria as a link between Alzheimer’s disease and diabetes 4th International Congress on Vascular Dementia
(Porto, Portugal)
2005/07/03 Brain mitochondrial dysfunction is a common feature in both diabetes and Alzheimer’s disease 19ª Reunião do grupo de estudos do envelhecimento cerebral e demência
(Tomar, Portugal)
2005/04 Effect of amyloid beta-peptide on brain mitochondria isolated from diabetic rats Mitochondria: Between Life and Death – International Courses on Toxicology
(Coimbra, Portugal)
2003/12/15 Diabetes and Alzheimer’s Disease: Are Brain Mitochondria a Link Between Both Pathologies? 1º Workshop de Bioquímica Clínica
(Porto, Portugal)
2003/12 Role of Insulin in Brain Mitochondria Status of Type 1 Diabetic Rats. Does Amyloid beta-Peptide Interferes with Mitochondrial Function? 16st Luso-Spanish Congress on Free Radicals / 6th Portuguese Congress on Free Radicals in Chemistry, Biology and Medicine
2002/07/14 Bioenergética mitocondrial e o envelhecimento 16ª Reunião-Grupo de Estudos – Envelhecimento Cerebral e Demência
2001 Mitochondria: a target for beta-amyloid peptide XXXII Reunião Anual da Sociedade Portuguesa de Farmacologia e XX Reunião de Farmacologia Clínica
(Coimbra, Portugal)
2000/07/02 Mitocôndria e o envelhecimento: efeito do peptídeo Abeta25-35 14ª Reunião - Grupo de Estudos: Envelhecimento Cerebral e Demência

Event organisation

Event name
Type of event (Role)
Institution / Organization
2022/04/04 - 2022/04/08 Advanced Course "Metabolic and inflammatory drivers in age-related neurodegenerative diseases" (2022/04/04)
Other (Co-organisor)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2019/05/23 - 2019/05/24 Symposium - Neurobiology of Aging; 53rd Annual Scientific Meeting of the European Society for Clinical Investigation (2019 - 2019)
Symposium
European Society for Clinical Investigation, Netherlands
2019/04/08 - 2019/04/12 Advanced Course - Neurodegenerative Disorders PhD Programme in Experimental Biology and Biomedicine (2019 - 2019)
Other (Co-organisor)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2013/02/25 - 2013/03/01 Advanced Course - Neurobiology and Disease Doctoral Programme in Health Sciences (2013 - 2013)
Other (Co-organisor)
Universidade de Coimbra - Faculdade de Medicina, Portugal
2012/12/10 - 2012/12/14 Advanced Course - Biology of Proteolysis in Pathology; PhD Programme in Experimental Biology and Biomedicine (2012 - 2012)
Other (Co-organisor)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Event participation

Activity description
Type of event
Event name
Institution / Organization
2022/07/18 - 2022/07/18 Session chair - International Research Conference on Neurodegenerative Diseases
Conference
International Research Conference on Neurodegenerative Diseases

Association member

Society Organization name Role
2007 - Current Portuguese Society of Diabetology Membro
2007 - Current European Association for the Study of Diabetes Membro
2006 - Current Portuguese Society for Neuroscience Membro

Committee member

Activity description
Role
Institution / Organization
2022/07/18 - 2022/07/19 IRCND 2022 Long Range Planning Committee
Member
2019/05/22 - 2019/05/24 Scientific committee - 53rd Annual Meeting of the European Society for Clinical Investigation (ESCI)
Member
European Society for Clinical Investigation, Netherlands
2018/07/13 - 2018/07/13 Scientific Committee - International Symposium; MitoPorto – Mitochondrial evolution, metabolism and disease
Other
2013/05/30 - 2013/06/01 Organizing committee - XIII Reunião da Sociedade Portuguesa de Neurociências
Member

Conference scientific committee

Conference name Conference host
2022/07/01 - 2022/07/02 36ª Reunião Anual do Grupo de Estudos de Envelhecimento Cerebral e Demência

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2012 - Current Fundamentos de Fisiologia II Licenciatura em Química Medicinal (Licenciatura) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2011/02 - Current Fisiologia Humana Geral Mestrado Integrado em Medicina Dentária (Mestrado integrado) Universidade de Coimbra - Faculdade de Medicina, Portugal
2011 - Current Fundamentos de Fisiologia I Licenciatura em Química Medicinal (Licenciatura) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2009 - Current Fundamentos de Fisiologia II Mestrado Integrado em Engenharia Biomédica (Mestrado integrado) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2008 - Current Fundamentos de Fisiologia I Mestrado Integrado em Engenharia Biomédica (Mestrado integrado) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2006/02 - Current Fisiologia II (Mestrado integrado) Universidade de Coimbra - Faculdade de Medicina, Portugal
2005/12/01 - Current Fisiologia I Mestrado Integrado em Medicina (Mestrado integrado) Universidade de Coimbra - Faculdade de Medicina, Portugal

Evaluation committee

Activity description
Role
Institution / Organization Funding entity
2016 - Current Evaluator for European Science Foundation
Evaluator
European Science Foundation, France
2021 - 2021 Evaluator of the reports submitted by Doctorate Researchers (Decreto-Lei n.º 57/2016)
Evaluator
Faculty of Medicine, University of Coimbra, Portugal
2016 - 2021 Evaluator of the Marie Sklodowska-Curie Individual Fellowships (Life Sciences Panel)
Evaluator
European Commission, Belgium European Commission
2016 - 2021 Evaluator of applications - Alzheimer's Association Research Grant Program
Evaluator
Alzheimer's Association, United States Alzheimer's Association
2019/12 - 2020/12 Committee Member on Novo Nordisk Foundation Challenge Programme 2020 - Biomedicine and Health Sciences
Evaluator
Novo Nordisk Fonden, Denmark Novo Nordisk Fonden
2018 - 2018 Evaluator of applications within the call "What causes Brain Disease?"
Evaluator
Lundbeckfonden, Denmark Lundbeckfonden
2016 - 2018 Evaluator of applications submitted to ANR Agence nationale de la recherche, France Agence nationale de la recherche
2014 - 2015 Evaluator Post-Doctoral Fellowships (Experimental Biology and Biochemistry Panel)
Evaluator
Fundação para a Ciência e a Tecnologia, I.P. (Lisbon, Portugal), Portugal Fundação para a Ciência e a Tecnologia, I.P. (Lisbon, Portugal)

Journal scientific committee

Journal title (ISSN) Publisher
2020/05 - Current Antioxidants & Redox Signaling (1557-7716) Mary Ann Liebert
2018 - Current Journal of Alzheimer's Disease Reports IOS Press
2018 - Current Diabetologia (1432-0428) Springer-Verlag
2018 - Current Brain Behavior and Immunity (1090-2139) Elsevier
2018 - Current Scientific Reports (2045-2322) Springer Science and Business Media LLC
2018 - Current Cellular and Molecular Life Sciences (1420-9071) Springer-Verlag
2018 - Current EClinicalMedicine (2589-5370) Elsevier
2018 - Current Nature Reviews Neurology (1759-4766) Springer Science and Business Media LLC
2018 - Current Neurotherapeutics (1878-7479) Springer-Verlag
2017 - Current Progress in Neurobiology (0301-0082) Elsevier
2017 - Current Alzheimers Disease & Dementia (2578-6490) sPage.direcT
2017 - Current American Journal of Alzheimer s Disease (1082-5207) SAGE Publications
2017 - Current Molecular Biology Reports (1573-4978) Springer-Verlag
2016 - Current Rejuvenation Research (1557-8577) Mary Ann Liebert
2016 - Current Diabetes Obesity and Metabolism (1463-1326) Wiley (Blackwell Publishing)
2016 - Current Nature Reviews Endocrinology (1759-5037) Springer Science and Business Media LLC
2016 - Current The Lancet Diabetes & Endocrinology (2213-8587) Elsevier
2015 - Current PeerJ (2167-8359) PeerJ
2015 - Current BioMed Research International (2314-6141) Hindawi Limited
2015 - Current Current Alzheimer Research (1567-2050) Bentham Science
2015 - Current Journal of Clinical Investigation (1558-8238) American Society for Clinical Investigation
2015 - Current Medicinal Research Reviews (1098-1128) Wiley (John Wiley & Sons)
2015 - Current Neuropathology and Applied Neurobiology (1365-2990) Wiley (Blackwell Publishing)
2015 - Current Expert Opinion on Drug Discovery (1746-045X) Informa UK (Taylor & Francis)
2015 - Current Molecular Neurobiology (0893-7648) Springer-Verlag
2015 - Current Trends in Neurosciences (0166-2236) Elsevier
2014 - Current Therapeutic Advances in Chronic Disease (2040-6231) SAGE Publications
2014 - Current Neuropharmacology (0028-3908) Elsevier
2014 - Current Aging Cell (1474-9728) Wiley (Blackwell Publishing)
2014 - Current Trends in Biotechnology (0167-7799) Elsevier
2013 - Current Expert Reviews in Molecular Medicine (1462-3994) Cambridge University Press
2012 - Current Frontiers in Aging Neuroscience (1663-4365) Frontiers Media SA
2012 - Current Diabetes
2012 - Current Neurobiology of Disease (1095-953X) Elsevier
2012 - Current Neurobiology of Disease (1095-953X) Elsevier
2012 - Current Free Radical Biology and Medicine (0891-5849) Elsevier
2012 - Current Neuroendocrinology (1423-0194) S. Karger AG
2012 - Current Biochemical Pharmacology (0006-2952) Elsevier
2012 - Current Journal of Neurochemistry (1471-4159) Wiley (Blackwell Publishing)
2010 - Current Journal of Alzheimer s Disease (1875-8908) IOS Press
2010 - Current Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (0925-4439) Elsevier
2010 - Current European Journal of Pharmacology (0014-2999) Elsevier
2009 - Current Antioxidants & Redox Signaling (1557-7716) Mary Ann Liebert
2009 - Current European Journal of Clinical Investigation (1365-2362) Wiley (Blackwell Publishing)
2009 - Current Neurosciences (1658-3183) Neurosciences
2008 - Current The FASEB Journal (1530-6860) Federation of American Society for Experimental Biology
2005 - Current Experimental Neurology (1090-2430) Elsevier
2004 - Current Expert Review of Neurotherapeutics (1744-8360) Informa UK (Taylor & Francis)
2013 - 2019 British Journal of Pharmacology (1476-5381) Wiley (Blackwell Publishing)
Distinctions

Award

2017 Orlando Leitão Prize
Sociedade Portuguesa de Neurologia, Portugal
2015 Mantero Belard Prize
Santa Casa da Misericórdia de Lisboa, Portugal
2014 2nd prize for research project
Sociedade Portuguesa de Diabetologia, Portugal
2013 Best Research Paper - Basic Science
Universidade de Coimbra - Faculdade de Medicina, Portugal
2010 ASN Neuro Poster Prize
American Society of Neurochemistry, United States
2008 L'Oreal for Women in Science award
L’Oreal Portugal , Portugal

Comissão Nacional da UNESCO , Portugal

Fundação para a Ciência e a Tecnologia, Portugal
2003 Stimulus to Research Prize
Fundação Calouste Gulbenkian, Portugal
2003 Best Poster Prize
Physiological Society, United Kingdom

Title

2021 Member of the Selection Committee Top 25 Outstanding Women Listeners 2021
2021 Member of Neurodegeneration Precision Medicine Initiative
2018 Member of the Dana Alliance for Brain Initiatives
Dana Foundation, United States
2018 Member of European Science Foundation (ESF) College of Expert Reviewers
European Science Foundation, France

Other distinction

2022 Member of Global Association for the Study of Neurodegenerative Diseases
2021 Expertscape World Expert in Mitochondria