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Paula I. Moreira received her PhD in Biomedical Sciences from University of Coimbra, Portugal, in 2007. Currently, she is Associate Professor at the Faculty of Medicine and Group Leader at the Center for Neuroscience and Cell Biology, University of Coimbra (CNC-UC), Portugal. Moreira's group is interested in 1) elucidating the role of energy metabolism, with an emphasis on mitochondria (energy, homeostasis and signals) and insulin/IGF-1-mediated signaling pathways in brain changes occurring in metabolic disorders (e.g. diabetes and obesity) and neurodegenerative diseases, particularly Alzheimer disease; 2) clarifying the role of hypoxia and sex/gender in the neurodegenerative events that characterize these pathologies; and 3) exploring the preventive and therapeutic potential of pharmacological (e.g. mitochondrial modulators) and non-pharmacological (e.g. hypoxic (pre)conditioning) strategies. Several experimental models are used such as isolated mitochondria, in vitro and in vivo/ex vivo models of disease and human samples. Moreira has published more than 250 scientific peer-reviewed scientific articles and book chapters. She is also a co-editor of the book "Alzheimer's Disease: New Beginnings" (ISBN print 978-1-61499-875-4; ISBN online 978-1-61499-876-1). She is Co-Editor-in-Chief of Journal of Alzheimer's Disease, Associate Editor of Journal of Alzheimer's Disease Reports and Frontiers of Aging Neuroscience, Section Editor of BBA-Molecular Basis of Disease and belongs to the editorial board of Antioxidants Redox Signaling and Aging Brain, among others. Moreira won several distinctions including the Stimulus to Research prize, in 2003, supported by the Calouste Gulbenkian Foundation, the L'Oréal for Women in Science Award, in 2008, supported by L'Oréal Portugal/UNESCO/FCT, and, in 2023, the RFS Award in Science for Antioxidants & Redox Signaling journal, supported by Mary Ann Liebert, Inc., in collaboration with the Rosalind Franklin Society. She has been recognized as a World Expert in Alzheimer's Disease and mitochondria by Expertscape, in addition to being named on the 2021 and 2022 editions of the prestigious World's Top 2% Scientists list compiled by Stanford University.
Identification

Personal identification

Full name
PAULA ISABEL DA SILVA MOREIRA

Citation names

  • Moreira, Paula
  • Paula I. Moreira
  • Moreira, PI
  • Moreira, Paula Isabel

Author identifiers

Ciência ID
9C16-2F47-6D91
ORCID iD
0000-0001-5177-6747
AuthenticusID
R-000-E6F
Google Scholar ID
https://scholar.google.pt/citations?user=5JO6pzkAAAAJ&hl=pt-PT
Researcher Id
B-3608-2009

Email addresses

  • pismoreira@gmail.com (Professional)
  • pimoreira@fmed.uc.pt (Professional)
  • venta@ci.uc.pt (Professional)

Addresses

  • Pólo III, Pólo das Ciências da Saúde, 3000-548, Azinhaga de Santa Comba, Celas, Coimbra, Portugal (Professional)
  • Centro de Neurociências e Biologia Celular, Universidade de Coimbra, Rua Larga, Faculdade de Medicina, Pólo I, 1º andar, 3004-504, Coimbra, Coimbra, Portugal (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Neurosciences

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Education
Degree Classification
2007/07/16
Concluded
Ciências Biomédicas (Doutoramento)
Major in Neurociências
Universidade de Coimbra - Faculdade de Medicina, Portugal
"Mitochondrial dysfunction in Alzheimer's disease and diabetes : effect of compounds with antioxidant properties" (THESIS/DISSERTATION)
Aprovado com Distinção e Louvor, por unanimidade
2002/05/23
Concluded
Biologia Celular (Mestrado)
Major in Não Aplicável
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Effect of Aß25-35 in the mitochondrial permeability transition pore: a comparative study " (THESIS/DISSERTATION)
1998/07/09
Concluded
Biologia (Licenciatura)
Major in Ramo Científico
Universidade de Coimbra - Faculdade de Ciências e Tecnologia, Portugal
Affiliation

Science

Category
Host institution
Employer
2007 - Current Researcher (Research) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Teaching in Higher Education

Category
Host institution
Employer
2024/01 - Current Associate Professor (University Teacher) Universidade de Coimbra - Faculdade de Medicina, Portugal
2016 - 2023/12 Assistant Professor (University Teacher) Universidade de Coimbra - Faculdade de Medicina, Portugal
Universidade de Coimbra - Faculdade de Medicina, Portugal
2014 - 2015 Invited Assistant Professor (University Teacher) University of Texas at San Antonio, United States
University of Texas at San Antonio College of Sciences, United States
2011 - 2015 Invited Assistant Professor (University Teacher) Universidade de Coimbra - Faculdade de Medicina, Portugal
Universidade de Coimbra - Faculdade de Medicina, Portugal
2005 - 2011 Assistant (University Teacher) Universidade de Coimbra - Faculdade de Medicina, Portugal
Universidade de Coimbra - Faculdade de Medicina, Portugal
Projects

Grant

Designation Funders
2022 - Current Zfra 1-31: an early intervention in T2D-associated neurodegeneration
EXPL/MED-FSL/0033/2021
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia, I.P. (Lisbon, Portugal)
Ongoing
2020/02 - Current Lipidomic fingerprint of MAMs in Alzheimer's disease - impact of its modulation on neuronal metabolism
SFRH/BD/148801/2019
Supervisor
Universidade de Coimbra - Faculdade de Medicina, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia, I.P. (Lisbon, Portugal)
Ongoing
2023 - 2024 Exploring the therapeutic potential of mitochondrial uncouplers in the context of Alzheimer's disease
ERG2023
Mentor
Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
European Society for Clinical Investigation
Ongoing
2022 - 2023 An exploratory study of the gender-specific response to hypoxia in Alzheimer's disease
ERG2022
Mentor
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
European Society for Clinical Investigation
Ongoing
2022 - 2023 MitoBOOST v2.0 - Prova de Conceito para o Uso de Polifenóis Dirigidos à Mitocôndria para Tratar a Doença do Fígado Gordo Não-Alcoólico
MitoBOOST v2.0
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Comissão de Coordenação e Desenvolvimento Regional do Centro
Ongoing
2021 - 2022 Zfra 1-31 peptide as a new candidate to fight type 2 diabetes-associated brain damage: a pilot study
ERG 2021
Mentor
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
European Society for Clinical Investigation
Ongoing
2019/04/01 - 2022 Rational Drug Design of novel potent multifunctional agents for Alzheimer's Disease treatment
SFRH/BD/138460/2018
Supervisor
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Coimbra Faculdade de Farmácia, Portugal
Fundação para a Ciência e a Tecnologia, I.P. (Lisbon, Portugal)
Concluded
2016/03/01 - 2019/03/31 Exploring the crosstalk of neuronal WWOX and mitochondria in type 2 diabetes-associated neurodegeneration
SFRH/BPD/107741/2015
Supervisor
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia, I.P. (Lisbon, Portugal)
Concluded
2016/07/01 - 2019/01/31 Unveiling the potential of HIF-1a as a biomarker and therapeutic target in Alzheimer’s disease
SFRH/BPD/109822/2015
Supervisor
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia, I.P. (Lisbon, Portugal)
Concluded
2017 - 2019 Unravelling the neuroprotective role of peripheral co-administration of liraglutide and ghrelin on brain and cognitive function in Huntington disease
SFRH/BPD/84473/2012
Supervisor
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Concluded
2015 - 2018 Does habitual physical activity mitigates chemotherapy-induced cardiac and brain dysfunction in a mouse model of prostate cancer? Role of mitochondrial-mediated mechanisms
SFRH/BPD/108322/2015
Supervisor
Universidade do Porto Centro de Investigação em Actividade Física Saúde e Lazer, Portugal
Concluded
2015 - 2018 HDAC3 neurophysiology and drug targeting in neurodegeneration
SFRH/BPD/102259/2014
Supervisor
Universidade do Porto Faculdade de Farmácia, Portugal
Fundação para a Ciência e a Tecnologia, I.P.
Concluded
2014/05/01 - 2017 Mild mitochondrial uncoupling: exploring its protective effects against brain damage associated to insulin-induced hypoglycemic events in type 1 diabetes
SFRH/BPD/95770/2013
Supervisor
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Coimbra - Faculdade de Ciências e Tecnologia, Portugal
Fundação para a Ciência e a Tecnologia, I.P. (Lisbon, Portugal)

Fundação para a Ciência e a Tecnologia, I.P.
Concluded
2013/03/01 - 2016/06/30 Mitochondrial trafficking in Alzheimer’s disease and hypoxic preconditioning: unveiling the role of the hypoxia up-regulated mitochondrial movement regulator
SFRH/BPD/84163/2012
Supervisor
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia, I.P. (Lisbon, Portugal)
Concluded
2013 - 2016 IMPACT OF PERIPHERAL EXENDIN-4 THERAPY ON THE MOLECULAR MECHANISMS UNDERLYING DIFFERENTIAL GENDER-RELATED BRAIN FUNCTION IN LONG-TERM TYPE 2 DIABETES
SFRH/BPD/84473/2012
Supervisor
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia, I.P. (Lisbon, Portugal)
Concluded
2009/03 - 2013/02 Diabetes-associated endothelium dysfunction: a cause of neurodegeneration? The role of brain endothelial mitochondria
SFRH/BD/43965/2008
Supervisor
Universidade de Coimbra - Faculdade de Ciências e Tecnologia, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia, I.P. (Lisbon, Portugal)
Concluded
2009/01/01 - 2012/12/31 DECIPHERING THE ROLE OF MITOCHONDRIA AND UNCOUPLING PROTEINS IN HYPOGLYCEMIA- AND/OR HYPERGLYCEMIA-INDUCED BRAIN INJURY
SFRH/BD/43968/2008
Supervisor
Universidade de Coimbra - Faculdade de Ciências e Tecnologia, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia, I.P. (Lisbon, Portugal)
Concluded
2008/03/01 - 2012/02/29 ROLE OF MITOCHONDRIA IN THE REGULATION OF THE TRANSCRIPTION FACTOR HYPOXIA-INDUCIBLE FACTOR-1 IN BRAIN ENDOTHELIUM: POTENTIAL PROTECTION AGAINST DIABETIC COMPLICATIONS
SFRH/BD/40702/2007
Supervisor
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Concluded
2007 - 2010 Impact of aging and gender in diabetic brain metabolism, oxidative stress and inflammation: Is there a (protective) role for insulin therapy?
SFRH/BPD/26872/2006
Supervisor
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Concluded
2002 - 2006 Mitocôndria e sua relação com o envelhecimento, a doença de Alzheimer e a diabetes: papel da proteína b-amilóide
SFRH/BD/5320/2001
PhD Student Fellow
Fundação para a Ciência e a Tecnologia, Portugal
Fundação para a Ciência e a Tecnologia
2000 - 2002 Efeito do peptídeo beta-amilóide no poro de permeabilidade transitória da mitocôndria
PRAXIS XXI/BM/20952/1999
Master Student Fellow
Universidade de Coimbra - Faculdade de Ciências e Tecnologia, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia, I.P. (Lisbon, Portugal)
Concluded

Contract

Designation Funders
2021/01/01 - 2025/12/31 Center for Innovative Biomedicine and Biotechnology - Associate Laboratory
LA/P/0058/2020
Universidade de Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2018 - 2022 The ups and downs of cellular stress: the MAMs hypothesis for Bipolar disorder pathophysiology
CENTRO-01-0145-FEDER-028214
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Concluded
2019/07 - 2021/07 A Saúde no Saber
45-2019/478
Researcher
Ciência Viva, Portugal
Ongoing
2017/01 - 2020 HealthyAging2020
HealthyAging2020 CENTRO-01-0145-FEDER-000012-N2323
Researcher
Comissão de Coordenação e Desenvolvimento Regional do Centro
2019/01/01 - 2019/12/31 CNC. IBILI
UID/NEU/04539/2019
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Coimbra, Portugal

Universidade de Coimbra Instituto de Ciências Nucleares Aplicadas à Saúde, Portugal

Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2016/04/01 - 2019/12/31 Tratamento do cancro e da doença de Alzheimer: à descoberta de novos fármacos
SII&DT 3269 Drugs2CAD
Researcher
Universidade de Coimbra, Portugal
Agência Nacional de Inovação, S.A.
Concluded
2018 - 2019 Brain protection by Evolocumab in individuals at high risk for cardiovascular disease: from bench to bedside
PEPITA2018
Principal investigator
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Universidade de Coimbra - Faculdade de Medicina
Concluded
2016 - 2018 Targeting huntingtin proteostasis and mitochondria to prevent neuronal dysfunction in Huntington's disease
PTDC/NEU-NMC/0412/2014
Researcher
Fundação para a Ciência e a Tecnologia, I.P. (Lisbon, Portugal)
2016 - 2018 The changing brain in Alzheimer's disease: is the retina a reliable mirror of disease onset and progression?
Prémio Mantero Belard 2015
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Concluded
2014/03 - 2015/02 Ageing@Coimbra: A Co-location Centre in the European Knowledge and Innovation Network for Active and Healthy Ageing
Researcher
Fundação para a Ciência e a Tecnologia, I.P.
Concluded
2014 - 2015 Selenate and Reduction of Neurofibrillary Tangle Formation: Role of Selenoproteins
U54MD008149
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
National Institute on Minority Health and Health Disparities
Concluded
2013 - 2015 Mitochondrial Trafficking In Alzheimer Disease: Revealing the Role of HUMMR
NIRG-13-282387
Principal investigator
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Alzheimer's Association
2013 - 2015 New Strategies to Manage Brain Diseases
CENTRO-07-ST24-FEDER-002002
Researcher
Programa Operacional Regional do Centro - Projecto Mais Centro
Concluded
2013 - 2014 Faulty cross-talk between endothelial cells and neurons in Alzheimer´s disease brain. Does endoplasmic reticulum stress play a role?
MOREIRA06JAN13
Principal investigator
Faculty of Medicine, University of Coimbra
2010/04 - 2013/09 Can Phytoestrogens be Safe and Effective Food Additives for Women During Menopause? - An In Vitro and In Vivo Approach to the problem.
Researcher
Fundação para a Ciência e a Tecnologia, I.P.
2011/03 - 2013/08 Mitochondrial preconditioning: potential neuroprotective effect in Alzheimer's disease
Principal investigator
Fundação para a Ciência e a Tecnologia, I.P.
2010/04/01 - 2013/07/15 Caloric restriction increases lifespan: role of neuropeptide Y on autophagy
PTDC/SAU-FCF/099082/2008
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2010/04 - 2013/03 The pathological interaction between diabetes and Alzheimer's disease: exploring the role of brain endothelial mitochondria and uncoupling proteins
Principal investigator
Fundação para a Ciência e a Tecnologia, I.P.
2011/01/01 - 2012/12/31 Strategic Project - LA 1 - 2011-2012
PEst-C/SAU/LA0001/2011
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2008/11 - 2012/03 A new route for endothelial dysfunction on diabetes: From phenotypes to molecules
Researcher
Fundação para a Ciência e a Tecnologia, I.P.
2011 - 2012 Influence of gender on the molecular mechanisms underlying aging-related changes in diabetic brain: the impact of insulin therapy
PMADSC
Principal investigator
Faculty of Medicine, University of Coimbra
2008 - 2010 Towards novel inhibitors of Alzheimer’s disease-associated beta-amyloid aggregation and toxicity: from statins as potential leads to the design of effective drugs
III-45
Principal investigator
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
Institute for Interdisciplinary Research, University of Coimbra
Concluded
2008 - 2009 Da diabetes à demência: Explorando as vias de sinalização mediadas pela mitocôndria e suas proteínas desacopladoras
----
Principal investigator
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Concluded
2007 - 2009 Exploring the crosstalk between mitochondrial reactive oxygen species and the transcriptional factor hypoxia factor-1 in brain and retinal endothelium
------
Principal investigator
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
European Foundation for the Study of Diabetes
Concluded
Outputs

Publications

Book
  1. Several. Alzheimer's Disease: New Beginnings. Netherlands: IOS Press BV. 2018.
    Published • Editor
Book chapter
  1. Cardoso, Susana; Moreira, Paula I.. "Neuro-glia communication and glycolysis". In Glycolysis, 27-50. Elsevier, 2024.
    10.1016/b978-0-323-91704-9.00006-9
  2. Carvalho, Cristina; Pires, Joana F.; Moreira, Paula I.; Raimundo, Nuno. "Disrupted cellular quality control mechanisms in aging". In Aging, 359-384. Elsevier, 2023.
    10.1016/b978-0-12-823761-8.00016-1
  3. Cardoso, Susana; Moreira, Paula I.. Corresponding author: Moreira, Paula I.. "Targeting Mitochondria and Redox Dyshomeostasis in Brain Ageing: An Update". In Redox Signaling and Biomarkers in Ageing, 147-183. Springer International Publishing, 2022.
    Published • 10.1007/978-3-030-84965-8_8
  4. Moreira, PI; Sónia C. Correia. "Unraveling the Role of Mitochondria in Alzheimer's Disease". In Vascular Disease, Alzheimer's Disease, and Mild Cognitive Impairment: Advancing an Integrated Approach, 407. Oxford, United States: Oxford University Press, USA, 2020.
    Published
  5. Cardoso, Susana; Moreira, Paula I.. "Antidiabetic drugs for Alzheimer's and Parkinson's diseases: Repurposing insulin, metformin, and thiazolidinediones". In Metabolic and Bioenergetic Drivers of Neurodegenerative Disease: Treating neurodegenerative diseases as metabolic diseases, 37-64. Elsevier, 2020.
    Published • 10.1016/bs.irn.2020.02.010
  6. Carvalho, Cristina; Moreira, Paula I.. "Cognitive Impairment in Obesity and Diabetes". In Obesity and Diabetes, 399-414. Springer International Publishing, 2020.
    10.1007/978-3-030-53370-0_29
  7. Correia, S.C.; Moreira, P.I.. "Role of mitochondria in neurodegenerative diseases: The dark side of the "Energy factory"". 2018.
  8. Cardoso, S.M.; Correia, S.C.; Carvalho, C.; Moreira, P.I.. "Mitochondria in Alzheimer’s disease and diabetes-associated neurodegeneration: License to heal!". 2017.
    10.1007/164_2017_3
  9. Cardoso, S.; Seiça, R.; Moreira, P.I.. "Diabesity and brain energy metabolism: The case of alzheimer’s disease". 2017.
    10.1007/978-3-319-63260-5_5
  10. Castellani, R.J.; Correia, S.C.; Moreira, P.I.; Perry, G.. "Tackling Alzheimer's Disease by Targeting Oxidative Stress and Mitochondria". 2016.
    10.1016/B978-0-12-802173-6.00018-6
  11. Correia, S.C.; Moreira, P.I.; Perry, G.. "Autophagy in alzheimer’s disease: A cleaning service out-of-order?". 2015.
    10.1007/978-3-319-13939-5_7
  12. Marques-Aleixo, I.; Santos-Alves, E.; Moreira, P.I.; Oliveira, P.J.; Magalhães, J.; Ascensão, A.. "Exercise-Induced Protection Against Aging and Neurodegenerative Diseases: Role of Redox- and Mitochondrial-Based Alterations". 2015.
    10.1002/9781118840634.ch26
  13. Nunes, A.R.; Alves, M.G.; Moreira, P.I.; Oliveira, P.F.; Silva, B.M.. "Impact of green tea (Camellia Sinensis L.) consumption in diabetes mellitus-induced neurodegeneration". 2015.
  14. Castellani, R.J.; Moreira, P.I.; Zhu, X.; Perry, G.. "Alzheimer's Disease: Pathology and Pathogenesis". 2014.
    10.1016/B978-0-12-801238-3.00160-4
  15. Santos, R.X.; Moreira, P.I.. "Mtor is a potential therapeutic target for alzheimer's disease". 2014.
  16. Santos, Renato; Correia, Sónia; Cardoso, Susana; Carvalho, Cristina; Candeias, Emanuel; Plácido, Ana; Duarte, ANA; Santos, Maria; Moreira, Paula. "Role of Mitochondria and Oxidative Stress in Parkinson¿s Disease". In Role of Oxidative Stress in Chronic Diseases, 521-548. United States: CRC Press, 2014.
    Published • 10.1201/b16653-26
  17. Carvalho, C.; Santos, R.X.; Cardoso, S.; Correia, S.C.; Moreira, P.I.. "Chronic hypoxia, type 2 diabetes and Alzheimer's disease: A dangerous triad". 2013.
  18. Duarte, A.; Candeias, E.; Correia, S.C.; Santos, R.X.; Carvalho, C.; Cardoso, S.; Plácido, A.I.; et al. "The Janus Face of Insulin in Brain". 2013.
    10.1002/9781118395318.ch5
  19. Cardoso, S.; Carvalho, C.; Correia, S.; Santos, R.X.; Santos, M.S.; Moreira, P.I.. "Mitochondrial uncoupling proteins - therapeutic targets in neurodegeneration?". 2011.
  20. Carvalho, C.; Correia, S.C.; Santos, R.X.; Cardoso, S.; Santos, M.S.; Moreira, P.I.. "Diabetes, mitochondria and brain endothelium dysfunction: A dangerous triad for neurodegeneration?". 2011.
  21. Nunomura, A.; Takeda, A.; Moreira, P.I.; Castellani, R.J.; Lee, H.-G.; Zhu, X.; Smith, M.A.; Perry, G.. "Neurofibrillary tangle formation as a protective response to oxidative stress in Alzheimer's disease". 2009.
    10.1007/978-0-387-87995-6_9
  22. Moreira, P.I.; Smith, M.A.; Zhu, X.; Nunomura, A.; Perry, G.. "The potential application of antioxidant agents in Alzheimer disease therapeutics". In Ageing research reviews. 2007.
    10.1007/978-0-387-71522-3_12
Conference abstract
  1. C Carvalho, SC Correia, S Cardoso, PI Moreira. Untangling the protective role of Zfra 1-31 peptide against type 2 diabet. "Untangling the protective role of Zfra 1-31 peptide against type 2 diabetes-associated brain damage: preliminary results of a pilot study". Paper presented in 56th Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI), Bari, 2022.
    Published
  2. Moreira, PI; Carvalho, Cristina. "Neuroprotective effects of Zfra 1-31 peptide against high glucose-induced mitochondrial and autophagy defects". Paper presented in 57th Annual Meeting of the European Association for the Study of Diabetes 2021 - EASD2021, 2021.
    Published
  3. Cardoso, Susana; Diano, Sabrina; Moreira, PI. "UCP2 inhibition modulates cognition and brain mitochondrial function under different metabolic insults.". Paper presented in 55th Annual Scientific Meeting of the European Society for Clinical Investigation - ESCI2021, 2021.
    Published
  4. T Fernandes; R Resende; MR Domingues; Moreira, PI; C Pereira. "Physical and biochemical alterations in endoplasmic reticulum-mitochondria contacts in an Alzheimer's disease in vitro model". Paper presented in 55th Annual Scientific Meeting of the European Society for Clinical Investigation - ESCI2021, 2021.
    Published
  5. D Mena; IN Alves; DF Silva; E Candeias; CR Oliveira,; R Seiça; PF Monteiro; Moreira, PI; AI Duarte. "The Neuroprotection by GLP-1 Receptor Agonists in High Cardiovascular risk and Neurodegenerative Diseases". Paper presented in 55th Annual Scientific Meeting of the European Society for Clinical Investigation - ESCI2021, 2021.
    Published
  6. S Correia; M Alves; P Oliveira; G Casadesus; G Perry; Moreira, PI. "Hypoxia preconditioning-triggered mitochondrial remodeling in a rat model of sporadic Alzheimer's disease: A" breath of fresh air" towards effective treatment?". Paper presented in 55th Annual Scientific Meeting of the European Society for Clinical Investigation - ESCI2021, 2021.
    Published
  7. Moreira, PI; C Carvalho. "WWOX inhibition in neuronal cells exposed to high glucose ameliorates mitochondrial dynamics and autophagy preventing cell death". Paper presented in 55th Annual Scientific Meeting of the European Society for Clinical Investigation - ESCI2021, 2021.
    Published
  8. C Carvalho; C Martin; Moreira, PI. "N epsilon-Carboxymethyl lysine induces mitochondrial-associated defects in differentiated SH-SY5Y neuroblastoma cells". Paper presented in 55th Annual Scientific Meeting of the European Society for Clinical Investigation - ESCI2021, 2021.
    Published
  9. D Franco da Silva; MI Alves; D Mena; D Vaz; PF Monteiro; Moreira, PI; AI Duarte. "The neuroprotective effects of peripheral treatment with Evolocumab in middle-aged rat at high cardiovascular risk". Paper presented in European Society for Clinical Investigation (ESCI) 2020: Utrecht, NL, Utrecht, 2020.
    Published
  10. D Mena; MI Alves; DF Silva; D Vaz; E Candeias; CR Oliveira; PF Monteiro; Moreira, PI; AI Duarte. "Diet-induced high cardiovascular risk compromises brain hippocampal metabolism and long-term spatial memory in middle-aged male rats". Paper presented in 53rd Annual Meeting of the European Society for Clinical Investigation, Utrecht, 2020.
    Published
  11. D Mena; MI Alves; M Sjogren; DF Silva; CR Oliveira; Moreira, PI; M Bjorkqvist; AI Duarte. "Co-administration of liraglutide and ghrelin ameliorates brain mitochondrial energy metabolism in the R6/2 mouse model for Huntington's disease". Paper presented in 53rd Annual Meeting of the European Society for Clinical Investigation, Utrecht, 2020.
    Published
  12. MI Alves; D Mena; DF Silva; R Seica; CR Oliveira; AI Duarte; Moreira, PI. "Type 2 diabetes mitigates brain cortical energy metabolism in middle-aged female rats". Paper presented in 53rd Annual Meeting of the European Society for Clinical Investigation, Utrecht, 2020.
    Published
  13. Agostinho Almeida; Marina C. Pinto; Paula Marinho Reis; Edgar Pinto; Paula I. Moreira; Sandra Freitas; Mário R. Simões. "Trace Elements Levels in Hair and Cognitive Status in an Elderly Environmentally Exposed Population: A Case Study in the Surroundings of an Industrial Area.". Paper presented in the 13th Biennial ISTERH2019 Conference, Bali, 2019.
    Published
  14. Ambrósio, A.F.; Chiquita, Samuel; Castelhano, Joao; Ribeiro, Mário; Sereno, José; Carecho, Rafael; Rodrigues-Neves AC; et al. "Is the retina a reliable window to look into the brain in Alzheirmer's disease? Lessons from an animal model". Paper presented in XXIII Biennial Meeting of the International Society for Eye Research, Belfast, 2018.
    Published
  15. António Francisco Ambrósio; Rodrigues-Neves AC; Samuel Chiquita; Carecho, Rafael; Filipa Baptista; Elisa Campos; Paula I. Moreira. "Structural, functional and molecular alterations in the retina of a mouse model of Alzheimer¿s disease". Paper presented in Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO), Honolulu, Hawaii, 2018.
    Published
  16. Rodrigues-Neves AC; Samuel Chiquita; Carecho, Rafael; Elisa Campos; Paula I. Moreira; Filipa Baptista; António Francisco Ambrósio. "Alzheimer¿s disease: can the retina be a window to the brain?". Paper presented in XX European Association for Vision and Eye Research (EVER), Nice, 2017.
    Published
  17. António Francisco Ambrósio; Samuel Chiquita; Rodrigues-Neves AC; Carecho, Rafael; Filipa Baptista; Elisa Campos; Paula I. Moreira. "Can the retina be used as a reliable mirror to evaluate changes occurring in the Alzheimer¿s brain?". Paper presented in Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO), Baltimore, 2017.
    Published
  18. Cavaco, JE; Rato, L.; Alves, Marco G.; Duarte, AI; Santos, MS; Moreira, PI; Olivera, PF. "How does Sertoli cell metabolism responds to the reduced testosterone levels induced by progressive stages of Diabetes Mellitus?". Paper presented in Medicine, 2016.
    10.1097/MD.0000000000002371
  19. Silva, BM; Alves, Marco G.; Nunes, AR; Dias, TR; Moreira, PI; Oliveira, PF. "White tea (Camellia sinensis) consumption improves heart and brain glycolytic and oxidative profiles in prediabetic rats". Paper presented in Planta Medica, 2015.
    10.1055/s-0035-1565707
  20. Rato, L.; Alves, Marco G.; Duarte, AI; Santos, MS; Moreira, PI; Cavaco, JE; Oliveira, PF. "Progressive stages of diabetes mellitus induce testosterone deficiency promoting a modulation of Sertoli cell metabolism". Paper presented in Human Reproduction, 2015.
    10.1093/humrep/30.Supplement_1.1
  21. Rato, L.; Duarte, AI; Tomás, GD; Santos, MS; Moreira, PI; Socorro, S; Cavaco, JE; Alves, Marco G.; Oliveira, PF. "Pre-diabetes disrupts testicular PGC1-a/SIRT3 axis prompting to oxidative stress". Paper presented in Biochimica et Biophysica Acta, 2015.
    10.1016/j.bbabio.2014.05.24
  22. Marques, Ricardo; Vaz, Cátia; Alves, M.G.; Moreira, PI; Oliveira PF; Cavaco, J.E.; Maia CJ; Socorro, Sílvia. "Androgens regulate gene expression of glucose transporters and glycolytic enzymes in prostate cancer cells". Paper presented in 16th European Congress of Endocrinology, Wroclaw, 2014.
    10.1530/endoabs.35.P571
  23. Cavaco, JE; Rato, L.; Alves, Marco G.; Dias, TR; Lopes, G.; Socorro, S.; Oliveira, PF; et al. "Fast Food may Induce Pre-Diabetes Impairing Testicular Function in Rats". Paper presented in VIII Annual CICS Symposium, 2013.
    10.1111/febs.12396
  24. Resende, Rosa; Moreira, Paula Isabel; Deshpande, Atul; Busciglio, Jorge; Pereira, Cláudia Fragão; Oliveira, Catarina R. "Increased oxidative stress is an early pathological feature in 3xTg-AD mice.". Paper presented in Alzheimer's Association International Conference on Alzheimer's Disease (ICAD), Chicago, 2008.
    Published • 10.1016/j.jalz.2008.05.2250
Conference poster
  1. Carvalho, Cristina; Paula I. Moreira. "Neuroprotective effects of Zfra 1-31 peptide against high glucose-induced mitochondrial and autophagy defects". Paper presented in 57th Annual Meeting of the European Association for the Study of Diabetes, 2021.
  2. Coimbra, Judite RM; Moreira, Paula Isabel; Santos, Armanda E; SALVADOR, J.A.R.. "Novel Glutaminyl Cyclase Inhibitors Discovered by Molecular Modeling Studies". Paper presented in 8th EFMC Young Medicinal Chemists¿ Symposium (EFMC-YMCS 2021), 2021.
  3. Coimbra, Judite RM; Moreira, Paula Isabel; Santos, Armanda E; Jorge A. R. Salvador, Salvador, J.. "A Virtual Screening Protocol to Identify Novel Inhibitors of Glutaminyl Cyclase". Paper presented in XXVI EFMC International Symposium on Medicinal Chemistry (EFMCISMC 2021, 2021.
  4. Coimbra, Judite R. M.; Baptista, Salete J.; Santos, Armanda E.; Moreira, Paula Isabel; Silva, Maria M.C; Dinis, Teresa C. P.; Jorge A. R. Salvador. "APPLICATION OF COMPUTATIONAL METHODS FOR DISCOVERY OF NOVEL BACE1 INHIBITORS: LIGAND- AND STRUCTURE-BASED PROTOCOLS WITH IN VITRO EVALUATION". Paper presented in 13th National Organic Chemistry Meeting & 6th National Medicinal Chemistry Meeting, January 15 - 17, 2020, Aveiro, Portugal, 2020.
  5. Coimbra, Judite RM; Baptista, Salete J.; Silva, MMC; Dinis, Teresa; Moreira, Paula Isabel; Santos, Armanda E; SALVADOR, J.A.R.. "Application of Computational Methods for Discovery of Novel BACE1 Hit Inhibitors: Ligand- and Structure-based Protocols with In Vitro Evaluation". Paper presented in the 13th National Organic Chemistry Meeting & 6th National Medicinal Chemistry Meeting, 2020.
  6. Mena, Débora; Alves, Inês N.; Sjögren M; Silva, Daniela; Oliveira CR; Moreira, PI; Björkqvist M; Duarte AI. "Dual therapy with liraglutide and ghrelin improves brain mitochondrial energy metabolism in the R6/2 mouse model for Huntington¿s disease". Paper presented in 1st Meeting of CIBB ¿ Center for Innovative Biomedicine & Biotechnology, 2020.
  7. Rodrigues-Neves AC; Carecho, Rafael; Filipa Baptista; Paula I. Moreira; António Francisco Ambrósio. "Do the retina and brain share similar glial patterns in an animal model of Alzheimer's disease?". Paper presented in XIV European Meeting on Glial Cells in Health and Disease, 2019.
  8. Moreira, PI. "Retinal thinning of inner layers is associated with visual cortex atrophy in a mouse model of Alzheimer's disease: a longitudinal in vivo multimodal study". Paper presented in ARVO Annual Meeting, 2019.
  9. Coimbra, Judite R. M.; Baptista, Salete J.; Santos, Armanda E; Moreira, Paula Isabel; Silva, Maria M.C; Dinis, Teresa C.P; Salvador, Jorge A. R.. "TARGETING ALZHEIMER¿S DISEASE: A VIRTUAL SCREENING PROTOCOL TO DISCOVER NEW CENTRAL-ACTING BACE1 INHIBITORS". Paper presented in Spring 2019 ACS National Meeting & Expo, Chemistry for New Frontiers, March 31 - April 4, 2019, Orlando, FL, USA, 2019.
  10. Coimbra, Judite R. M.; Baptista, Salete J.; Santos, Armanda E.; Moreira, Paula Isabel; Silva, Maria M. C.; Dinis, Teresa C.P; Salvador, Jorge A. R.. "TARGETING ALZHEIMER¿S DISEASE: AN INTEGRATED PROTOCOL OF VIRTUAL SCREENING FOR DISCOVERY OF NOVEL ANTI-BACE1 AGENTS". Paper presented in 14th International Conference on Alzheimer's and Parkinson's Diseases and related neurological disorders, March 26-31, 2019, Lisbon, Portugal, 2019.
  11. Sousa, Fábio J.; Carrascal, Mylene; Moreira, Paula Isabel; Santos, Armanda E; Cruz, Maria Teresa; Pereira, Cláudia. "Impact of ER stress on neuronal mitochondria". Paper presented in 1st Annual Meeting in Pharmaceutical Sciences, 2019.
  12. Rodrigues-Neves AC; Rafael Carecho; Elisa Campos; Paula I. Moreira; Filipa I. Baptista; António F. Ambrósio. "Is the retina a reliable mirror of Alzheimer¿s disease brain? screening of molecular and cellular parameters.". Paper presented in in ISER meeting, Belfast, Northern Ireland, UK., 2018.
  13. Rodrigues-Neves; Carecho, Rafael; Filipa Baptista; Paula I. Moreira; António Francisco Ambrósio. "Is the retina a reliable mirror of Alzheimer¿s disease brain? Screening of molecular and celular parameter". Paper presented in XXIII Biennial Meeting of the International Society for Eye Research (ISER), 2018.
  14. Pinho, Tiffany; Correia, SC; Moreira, PI. "The bittersweet side of O-GlcNacylation in Alzheimer's disease-related mitochondrial abnormalities.". Paper presented in MitoPorto - Mitochondrial Evolution, Metabolism and Disease, 2018.
  15. Pinho, Tiffany; Correia, SC; Moreira, PI. "The bittersweet relation between O-GlcNAcylation and Alzheimer's disease: a focus on mitochondria.". Paper presented in 52nd Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI) ¿ ¿Precision medicine for healthy aging¿, 2018.
  16. Diniz, A; Candeias, E; Duarte, AI; Moreira, PI; Silva, BM; Alves, MG; Rato, L.. "Type 2 diabetes mellitus disrupts the molecular axis SIRT1/PGC-1a/SIRT3 predisposing to oxidative environment in the rat epididymis". Paper presented in XIII ANNUAL CICS SYMPOSIUM, 2018.
  17. Alves, Marco G.; Rato, L.; Diniz, A; Candeias, E; Duarte, AI; Moreira, PI; Silva, BM; Alves, MG; Oliveira, PF. "Type 2 diabetes Mellitus compromises the epididymal SIRT1/PGC1-alpha/SIRT3 axis predisposing to oxidative environment". Paper presented in I NoTeS Congress, 2018.
  18. Rodrigues-Neves AC; Chiquita, S; Carecho, R; Baptista, FI; Moreira, PI; Ambrósio, AF. "Can the retina mirror the alterations observed in Alzheimer¿s disease brain at early stages?". Paper presented in Portuguese Glial Network, 2018.
  19. Pinho, Tiffany; Correia, SC; Moreira, PI. "O-GlcNAcylation represents a "sweet" route to tackle abnormal mitochondrial function and neuronal loss in Alzheimer's disease.". Paper presented in MitoPorto - Advances in mitochondrial research, 2017.
  20. Rodrigues-Neves AC; Samuel Chiquita; Rafael Carecho; Filipa I. Baptista; Paula I. Moreira; António F. Ambrósio. "The retina as a mirror of the alterations observed in Alzheimer¿s disease brain? Evaluation of structural, cellular and molecular changes.". Paper presented in XV SPN, Braga, Portugal., 2017.
  21. Rodrigues-Neves AC; Samuel Chiquita; Carecho, Rafael; Filipa Baptista; Paula I. Moreira; António Francisco Ambrósio. "The retina as a mirror of the alterations observed in Alzheimer¿s disease brain? Evaluation of structural, cellular and molecular change". Paper presented in XV Annual Meeting of the Portuguese Society for Neuroscience (SPN), 2017.
  22. Carecho, Rafael; Rodrigues-Neves AC; Filipa Baptista; Paula I. Moreira; António Francisco Ambrósio. "Are the main features of Alzheimer¿s brain mirrored by the retina?". Paper presented in XV Annual Meeting of the Portuguese Society for Neuroscience (SPN), 2017.
  23. Correia, SC; Moreira, PI. "Type 2 diabetic female rat brains are less vulnerable to oxidative stress and Alzheimer disease-related hallmarks: a role for insulin/igf-1/estrogen signaling?". Paper presented in XII CNC Annual Meeting, 2015.
  24. Correia SC; Pinho TS; Zhu X; Perry, George; Moreira, PI. "Loss of HUMMR participates on mitochondrial traffic jams.". Paper presented in XIV Meeting of the Portuguese Society for Neuroscience, 2015.
  25. Rato, L.; Alves, MG; Santos, MS; Moreira, PI; Cavaco, JE; Duarte, AI; Oliveira, PF. "Impact of Reduced Testosterone Levels Induced by Progressive Stages of Diabetes Mellitus on Sertoli cells Glycolytic and Bioenergetic Profiles". Paper presented in I congress in health sciences. Towards innovation and entrepeneurship: trends in endocrinology and neurosciences, 2015.
  26. Correia, SC; Moreira, PI. "Stimulation of mitochondrial biogenesis and mitochondrial elongation during preconditioning: the brain adapting to survive!". Paper presented in 38th FEBS Congress, 2013.
  27. Correia, SC; Moreira, PI. "Effects of type 1 diabetes and insulin therapy on brain mitochondrial dynamics and autophagy.". Paper presented in XIII Meeting of the Portuguese Society for Neuroscience, 2013.
  28. Correia, SC; Moreira, PI. "Mitoplasticity during hypoxic preconditioning: the brain battles to survive!". Paper presented in XIII Meeting of the Portuguese Society for Neuroscience, 2013.
  29. Correia, SC; Moreira, PI. "Tolerância cerebral mediada pelo pré-condicionamento por hipóxia num modelo animal de insulino-resistência central". Paper presented in Annual meeting of the Portuguese Society of Diabetology, 2013.
  30. Rato, L.; Duarte, AI; Alves, Marco G.; Santos, MS; Moreira, PI; Cavaco, PE; Socorro, S.; Oliveira, PF. "Testicular mitochondrial bioenergetics is altered in pre-diabetes induced by a high-energy diet in rats". Paper presented in FEBS Congress, 2013.
  31. Ferreiro, Elisabete; Ana Isabel Plácido; Catarina Resende de Oliveira; Moreira, Paula Isabel; Cláudia Maria Fragão Pereira. "Role of endoplasmic reticulum in the endothelial-neuronal dialogue in Alzheimer´s disease". Paper presented in 8th Forum of European Neuroscience, Barcelona, Spain, 2012.
  32. Neuhaus-Oliveira, A.; Alves, Marco G.; Moreira, PI; Socorro, S; Oliveira, PF. "Exposure to 2,4-Dichlorophenoxyacetic Acid induces important metabolic alterations in Sertoli cells that may compromise the spermatogenesis". Paper presented in VII CICS Symposium, 2012.
  33. Ana Isabel Plácido; Ferreiro, Elisabete; Catarina Resende de Oliveira; Cláudia Maria Fragão Pereira; Moreira, Paula Isabel. "Endoplasmic reticulum stress induces brain endothelial cells dysfunction and death independently of caspase-12 pathway". Paper presented in 1st PF2MUC Symposium, Coimbra, Portugal, 2011.
  34. Susana Cardoso; Renato X. Santos; Cristina Carvalho; Sónia Correia; Sandrina Silva; Gonçalo C. Pereira; Susana P. Pereira; et al. "Brain mitochondria as a potential target of doxorubicin action". Paper presented in IV International Courses on Toxicology 2008 ¿ ¿Metabolic Toxicology: From the Pathway to Organism¿, 2008.
Journal article
  1. Fernandes, Tânia; Melo, Tânia; Conde, Tiago; Neves, Bruna; Domingues, Pedro; Resende, Rosa; Pereira, Cláudia F.; Moreira, Paula I.; Domingues, Maria Rosário. "Mapping the lipidome in mitochondria-associated membranes (MAMs) in an in vitro model of Alzheimer's disease". Journal of Neurochemistry (2024): http://dx.doi.org/10.1111/jnc.16072.
    10.1111/jnc.16072
  2. Tiago Sousa; Paula I. Moreira; Susana Cardoso. "Current Advances in Mitochondrial Targeted Interventions in Alzheimer's Disease". Biomedicines (2023): https://doi.org/10.3390/biomedicines11092331.
    10.3390/biomedicines11092331
  3. Coimbra, Judite R.M.; Moreira, Paula I.; Santos, Armanda E.; Salvador, Jorge A.R.. "Therapeutic potential of glutaminyl cyclases: Current status and emerging trends". Drug Discovery Today (2023): 103644. http://dx.doi.org/10.1016/j.drudis.2023.103644.
    10.1016/j.drudis.2023.103644
  4. Batista, Ana; Guimarães, Pedro; Martins, João; Moreira, Paula I.; Ambrósio, António Francisco; Castelo-Branco, Miguel; Serranho, Pedro; Bernardes, Rui. "Normative mice retinal thickness: 16-month longitudinal characterization of wild-type mice and changes in a model of Alzheimer's disease". Frontiers in Aging Neuroscience 15 (2023): http://dx.doi.org/10.3389/fnagi.2023.1161847.
    10.3389/fnagi.2023.1161847
  5. Batista, Ana; Guimarães, Pedro; Serranho, Pedro; Nunes, Ana; Martins, João; Moreira, Paula I.; Ambrósio, António Francisco; et al. "Retinal imaging in animal models: Searching for biomarkers of neurodegeneration". Frontiers in Ophthalmology 3 (2023): http://dx.doi.org/10.3389/fopht.2023.1156605.
    10.3389/fopht.2023.1156605
  6. Cristina Carvalho; Paula I. Moreira. "Metabolic defects shared by Alzheimer's disease and diabetes: A focus on mitochondria". Current Opinion in Neurobiology (2023): https://doi.org/10.1016/j.conb.2023.102694.
    10.1016/j.conb.2023.102694
  7. Tânia Fernandes; M. Rosário Domingues; Paula I. Moreira; Cláudia F. Pereira. "A Perspective on the Link between Mitochondria-Associated Membranes (MAMs) and Lipid Droplets Metabolism in Neurodegenerative Diseases". Biology (2023): https://doi.org/10.3390/biology12030414.
    10.3390/biology12030414
  8. Pinho, Brígida R.; Duarte, Ana I.; Canas, Paula M.; Moreira, Paula I.; Murphy, Michael P.; Oliveira, Jorge M.A.. "Redox signalling and proteostasis in neurodegeneration: In vivo effects of the mitochondria-targeted antioxidant MitoQ in Huntington's disease mice". Free Radical Biology and Medicine 198 (2023): S5-S6. http://dx.doi.org/10.1016/j.freeradbiomed.2022.12.030.
    10.1016/j.freeradbiomed.2022.12.030
  9. Bernardes, Rui; Ghalati, Maryam; Ferreira, Hugo; Martins, João; Guimarães, Pedro; Moreira, Paula; Ambrósio, António; Castelo-Branco, Miguel; Serranho, Pedro. "Longitudinal OCT texture analysis to assess the retinal changes in the triple-transgenic mouse model of Alzheimer's disease". Acta Ophthalmologica 100 S275 (2022): http://dx.doi.org/10.1111/j.1755-3768.2022.0173.
    10.1111/j.1755-3768.2022.0173
  10. Cristina Carvalho; Sónia C. Correia; Raquel Seiça; Paula I. Moreira. "WWOX inhibition by Zfra1-31 restores mitochondrial homeostasis and viability of neuronal cells exposed to high glucose". Cellular and Molecular Life Sciences (2022): https://doi.org/10.1007/s00018-022-04508-7.
    10.1007/s00018-022-04508-7
  11. Ferreira, Hugo; Serranho, Pedro; Guimarães, Pedro; Trindade, Rita; Martins, João; Moreira, Paula I.; Ambrósio, António Francisco; Castelo-Branco, Miguel; Bernardes, Rui. "Stage-independent biomarkers for Alzheimer’s disease from the living retina: an animal study". Scientific Reports 12 1 (2022): http://dx.doi.org/10.1038/s41598-022-18113-y.
    10.1038/s41598-022-18113-y
  12. Antónia Diniz; Marco G. Alves; Emanuel Candeias; Ana I. Duarte; Paula I. Moreira; Branca M. Silva; Pedro F. Oliveira; Luís Rato. "Type 2 Diabetes Induces a Pro-Oxidative Environment in Rat Epididymis by Disrupting SIRT1/PGC-1a/SIRT3 Pathway". International Journal of Molecular Sciences (2022): https://doi.org/10.3390/ijms23168912.
    10.3390/ijms23168912
  13. Guimarães, Pedro; Serranho, Pedro; Martins, João; Moreira, Paula I.; Ambrósio, António Francisco; Castelo-Branco, Miguel; Bernardes, Rui. "Retinal Aging in 3× Tg-AD Mice Model of Alzheimer's Disease". Frontiers in Aging Neuroscience 14 (2022): http://dx.doi.org/10.3389/fnagi.2022.832195.
    10.3389/fnagi.2022.832195
  14. Pereira, Ana Catarina; De Pascale, Jessica; Resende, Rosa; Cardoso, Susana; Ferreira, Isabel; Neves, Bruno Miguel; Carrascal, Mylène A.; et al. "ER-mitochondria communication is involved in NLRP3 inflammasome activation under stress conditions in the innate immune system". Cellular and Molecular Life Sciences 79 4 (2022): http://dx.doi.org/10.1007/s00018-022-04211-7.
    10.1007/s00018-022-04211-7
  15. Correia, Sónia C.; Alves, Marco G.; Oliveira, Pedro F.; Casadesus, Gemma; LaManna, Joseph; Perry, George; Moreira, Paula I.. "Hypoxic preconditioning averts sporadic Alzheimer’s disease-like phenotype in rats: a focus on mitochondria". Antioxidants & Redox Signaling (2022): http://dx.doi.org/10.1089/ars.2019.8007.
    10.1089/ars.2019.8007
  16. Susana Cardoso; Paula I. Moreira. "Insulin-Induced Recurrent Hypoglycemia Up-Regulates Glucose Metabolism in the Brain Cortex of Chemically Induced Diabetic Rats". International Journal of Molecular Sciences (2021): https://doi.org/10.3390/ijms222413470.
    10.3390/ijms222413470
  17. Sónia C. Correia; Paula I. Moreira. "Oxygen Sensing and Signaling in Alzheimer's Disease: A Breathtaking Story!". Cellular and Molecular Neurobiology (2021): https://doi.org/10.1007/s10571-021-01148-6.
    10.1007/s10571-021-01148-6
  18. Tânia Fernandes; Rosa Resende; Diana F. Silva; Ana P. Marques; Armanda E. Santos; Sandra M. Cardoso; M. Rosário Domingues; Paula I. Moreira; Cláudia F. Pereira. "Structural and Functional Alterations in Mitochondria-Associated Membranes (MAMs) and in Mitochondria Activate Stress Response Mechanisms in an In Vitro Model of Alzheimer's Disease". Biomedicines 9 8 (2021): 881-881. https://doi.org/10.3390/biomedicines9080881.
    10.3390/biomedicines9080881
  19. Ferreira, Hugo; Martins, João; Moreira, Paula I.; Ambrósio, António Francisco; Castelo-Branco, Miguel; Serranho, Pedro; Bernardes, Rui. "Longitudinal normative OCT retinal thickness data for wild-type mice, and characterization of changes in the 3×Tg-AD mice model of Alzheimer's disease". Aging (2021): http://dx.doi.org/10.18632/aging.202916.
    10.18632/aging.202916
  20. Carvalho, Cristina; Moreira, Paula I.. "WWOX: A New Therapeutic Target In Type 2 Diabetes-Associated Neurodegeneration". Metabolism 116 (2021): 154616. http://dx.doi.org/10.1016/j.metabol.2020.154616.
    10.1016/j.metabol.2020.154616
  21. Susana Cardoso; Icíar López; Sergio Piñeiro-Hermida; José Pichel; Paula Moreira. "IGF1R Deficiency Modulates Brain Signaling Pathways and Disturbs Mitochondria and Redox Homeostasis". Biomedicines 9 2 (2021): 158-158. https://doi.org/10.3390/biomedicines9020158.
    10.3390/biomedicines9020158
  22. Sónia C. Correia; Nuno J. Machado; Marco G. Alves; Pedro F. Oliveira; Paula I. Moreira. "Intermittent Hypoxic Conditioning Rescues Cognition and Mitochondrial Bioenergetic Profile in the Triple Transgenic Mouse Model of Alzheimer's Disease". International Journal of Molecular Sciences 22 1 (2021): 461-461. https://doi.org/10.3390/ijms22010461.
    10.3390/ijms22010461
  23. Klionsky, Daniel J.; Abdel-Aziz, Amal Kamal; Abdelfatah, Sara; Abdellatif, Mahmoud; Abdoli, Asghar; Abel, Steffen; Abeliovich, Hagai; et al. "Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1". Autophagy 17 1 (2021): 1-382. http://dx.doi.org/10.1080/15548627.2020.1797280.
    10.1080/15548627.2020.1797280
  24. Quinn, Peter M. J.; Moreira, Paula I.; Ambrósio, António Francisco; Alves, C. Henrique. "PINK1/PARKIN signalling in neurodegeneration and neuroinflammation". Acta Neuropathologica Communications 8 1 (2020): http://dx.doi.org/10.1186/s40478-020-01062-w.
    Published • 10.1186/s40478-020-01062-w
  25. Bianca Gerardo; Marina Cabral Pinto; Joana Nogueira; Paula Pinto; Agostinho Almeida; Edgar Pinto; Paula Marinho-Reis; et al. "Associations between Trace Elements and Cognitive Decline: An Exploratory 5-Year Follow-Up Study of an Elderly Cohort". International Journal of Environmental Research and Public Health (2020): https://doi.org/10.3390/ijerph17176051.
    10.3390/ijerph17176051
  26. Cunnane, Stephen C.; Trushina, Eugenia; Morland, Cecilie; Prigione, Alessandro; Casadesus, Gemma; Andrews, Zane B.; Beal, M. Flint; et al. "Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing". Nature Reviews Drug Discovery (2020): http://dx.doi.org/10.1038/s41573-020-0072-x.
    10.1038/s41573-020-0072-x
  27. Resende, R.; Fernandes, T.; Pereira, A.C.; De Pascale, J.; Marques, A.P.; Oliveira, P.; Morais, S.; et al. "Mitochondria, endoplasmic reticulum and innate immune dysfunction in mood disorders: Do Mitochondria-Associated Membranes (MAMs) play a role?". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1866 6 (2020): 165752. http://dx.doi.org/10.1016/j.bbadis.2020.165752.
    10.1016/j.bbadis.2020.165752
  28. Ferreira, Hugo; Martins, João; Nunes, Ana; Moreira, Paula I.; Castelo-Branco, Miguel; Ambrósio, António Francisco; Serranho, Pedro; Bernardes, Rui. "Characterization of the retinal changes of the 3×Tg-AD mouse model of Alzheimer's disease". Health and Technology (2020): 1816-1821. http://dx.doi.org/10.1007/s12553-020-00413-w.
    10.1007/s12553-020-00413-w
  29. Coimbra, Judite R. M.; Baptista, Salete J.; Dinis, Teresa C. P.; Silva, Maria M. C.; Moreira, Paula I.; Santos, Armanda E.; Salvador, Jorge A. R.. "Combining Virtual Screening Protocol and In Vitro Evaluation towards the Discovery of BACE1 Inhibitors". Biomolecules 10 4 (2020): 535. http://dx.doi.org/10.3390/biom10040535.
    10.3390/biom10040535
  30. Ana I. Duarte; Emanuel Candeias; Inês N. Alves; Débora Mena; Daniela F. Silva; Nuno J. Machado; Elisa J. Campos; et al. "Liraglutide Protects Against Brain Amyloid-ß1-42 Accumulation in Female Mice with Early Alzheimer's Disease-Like Pathology by Partially Rescuing Oxidative/Nitrosative Stress and Inflammation". International Journal of Molecular Sciences (2020): https://doi.org/10.3390/ijms21051746.
    10.3390/ijms21051746
  31. Pinho, Brígida R.; Duarte, Ana I.; Canas, Paula M.; Moreira, Paula I.; Murphy, Michael P.; Oliveira, Jorge M.A.. "The interplay between redox signalling and proteostasis in neurodegeneration: In vivo effects of a mitochondria-targeted antioxidant in Huntington's disease mice". Free Radical Biology and Medicine 146 (2020): 372-382. http://dx.doi.org/10.1016/j.freeradbiomed.2019.11.021.
    10.1016/j.freeradbiomed.2019.11.021
  32. Nunes, Ana; Ambrósio, António Francisco; Santana, Isabel; Santiago, Beatriz; Moreira, Paula; Castelo-Branco, Miguel; Bernardes, Rui. "Texture biomarkers of Alzheimer's disease: human vs. mouse model of disease". Alzheimer's Research & Therapy (2020):
    Submitted
  33. Bernardes, Rui; Ferreira, Hugo; Martins, Joao; Moreira, Paula; Francisco Ambrosio, Antonio; Castelo-Branco, Miguel; Serranho, Pedro. "Characterization of the retina of the triple-transgenic mice model of Alzheimer's disease: onset and progression of the disease". Neurology (2020): https://publons.com/wos-op/publon/40788837/.
  34. Coimbra, Judite RM; Sobral, Pedro JM; Santos, Armanda E; Moreira, Paula I; Salvador, Jorge AR. "An overview of glutaminyl cyclase inhibitors for Alzheimer’s disease". Future Medicinal Chemistry 11 24 (2019): 3179-3194. http://dx.doi.org/10.4155/fmc-2019-0163.
    10.4155/fmc-2019-0163
  35. Pereira, Claudia F.; Santos, Armanda E.; Moreira, Paula I.; Pereira, Ana Catarina; Sousa, Fabio J.; Cardoso, Sandra M.; Cruz, M. Teresa. "Is Alzheimer's disease an inflammasomopathy?". Ageing Research Reviews 56 (2019): 100966. http://dx.doi.org/10.1016/j.arr.2019.100966.
    10.1016/j.arr.2019.100966
  36. Bernardes, Rui; Ferreira, Hugo; Martins, João; Moreira, Paula I.; Castelo-Branco, Miguel; Ambrósio, António F.; Serranho, Pedro. "Retinal thickness of the triple-transgenic mice model of Alzheimer's disease at the age of one month". Acta Ophthalmologica 97 S263 (2019): http://dx.doi.org/10.1111/j.1755-3768.2019.5467.
    10.1111/j.1755-3768.2019.5467
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  216. Moreira, P.I.; Siedlak, S.L.; Aliev, G.; Zhu, X.; Cash, A.D.; Smith, M.A.; Perry, G.. "Oxidative stress mechanisms and potential therapeutics in Alzheimer disease". Journal of Neural Transmission 112 7 (2005): 921-932. http://www.scopus.com/inward/record.url?eid=2-s2.0-20944449836&partnerID=MN8TOARS.
    10.1007/s00702-004-0242-8
  217. Honda, K.; Smithi, M.A.; Zhu, X.; Baus, D.; Merrick, W.C.; Tartakoff, A.M.; Hattier, T.; et al. "Ribosomal RNA in Alzheimer disease is oxidized by bound redox-active iron". Journal of Biological Chemistry 280 22 (2005): 20978-20986. http://www.scopus.com/inward/record.url?eid=2-s2.0-20444383489&partnerID=MN8TOARS.
    10.1074/jbc.M500526200
  218. Cardoso, S.M.; Moreira, P.I.; Agostinho, P.; Pereira, C.; Oliveira, C.R.. "Neurodegenerative pathways in Parkinson's disease: Therapeutic strategies". Current Drug Targets: CNS and Neurological Disorders 4 4 (2005): 405-419. http://www.scopus.com/inward/record.url?eid=2-s2.0-23144431757&partnerID=MN8TOARS.
    10.2174/1568007054546072
  219. Lee, H.-G.; Perry, G.; Moreira, P.I.; Garrett, M.R.; Liu, Q.; Zhu, X.; Takeda, A.; Nunomura, A.; Smith, M.A.. "Tau phosphorylation in Alzheimer's disease: Pathogen or protector?". Trends in Molecular Medicine 11 4 (2005): 164-169. http://www.scopus.com/inward/record.url?eid=2-s2.0-17044435830&partnerID=MN8TOARS.
    10.1016/j.molmed.2005.02.008
  220. Moreira, P.I.; Santos, M.S.; Sena, C.; Seiça, R.; Oliveira, C.R.. "Insulin protects against amyloid ß-peptide toxicity in brain mitochondria of diabetic rats". Neurobiology of Disease 18 3 (2005): 628-637. http://www.scopus.com/inward/record.url?eid=2-s2.0-14744294296&partnerID=MN8TOARS.
    10.1016/j.nbd.2004.10.017
  221. Moreira, P.I.; Oliveira, C.R.; Santos, M.S.; Nunomura, A.; Honda, K.; Zhu, X.; Smith, M.A.; Perry, G.. "A second look into the oxidant mechanisms in Alzheimer's disease". Current Neurovascular Research 2 2 (2005): 179-184. http://www.scopus.com/inward/record.url?eid=2-s2.0-18744402471&partnerID=MN8TOARS.
    10.2174/1567202053586758
  222. Smith, M.A.; Nunomura, A.; Lee, H.-G.; Zhu, X.; Moreira, P.I.; Avila, J.; Perry, G.. "Chronological primacy of oxidative stress in Alzheimer disease". Neurobiology of Aging 26 5 (2005): 579-580. http://www.scopus.com/inward/record.url?eid=2-s2.0-13644249113&partnerID=MN8TOARS.
    10.1016/j.neurobiolaging.2004.09.021
  223. Webber, K.M.; Smith, M.A.; Lee, H.-G.; Harris, P.L.; Moreira, P.; Perry, G.; Zhu, X.. "Mitogen- and stress-activated protein kinase 1: Convergence of the ERK and p38 pathways in Alzheimer's disease". Journal of Neuroscience Research 79 4 (2005): 554-560. http://www.scopus.com/inward/record.url?eid=2-s2.0-14144250344&partnerID=MN8TOARS.
    10.1002/jnr.20380
  224. Moreira, P.I.; Custódio, J.B.; Oliveira, C.R.; Santos, M.S.. "Brain mitochondrial injury induced by oxidative stress-related events is prevented by tamoxifen". Neuropharmacology 48 3 (2005): 435-447. http://www.scopus.com/inward/record.url?eid=2-s2.0-13844275276&partnerID=MN8TOARS.
    10.1016/j.neuropharm.2004.10.012
  225. Moreira, P.I.; Honda, K.; Liu, Q.; Aliev, G.; Oliveira, C.R.; Santos, M.S.; Zhu, X.; Smith, M.A.; Perry, G.. "Alzheimer's disease and oxidative stress: The old problem remains unsolved". Current Medicinal Chemistry - Central Nervous System Agents 5 1 (2005): 51-62. http://www.scopus.com/inward/record.url?eid=2-s2.0-15344351142&partnerID=MN8TOARS.
  226. Liu, Q.; Smith, M.A.; Avilá, J.; DeBernardis, J.; Kansal, M.; Takeda, A.; Zhu, X.; et al. "Alzheimer-specific epitopes of tau represent lipid peroxidation-induced conformations". Free Radical Biology and Medicine 38 6 (2005): 746-754. http://www.scopus.com/inward/record.url?eid=2-s2.0-13844267510&partnerID=MN8TOARS.
    10.1016/j.freeradbiomed.2004.11.005
  227. Moreira, P.I.; Smith, M.A.; Zhu, X.; Honda, K.; Lee, H.-G.; Aliev, G.; Perry, G.. "Oxidative damage and Alzheimer's disease: Are antioxidant therapies useful?". Drug News and Perspectives 18 1 (2005): 13-19. http://www.scopus.com/inward/record.url?eid=2-s2.0-17444377148&partnerID=MN8TOARS.
    10.1358/dnp.2005.18.1.877165
  228. Lee, H.-G.; Moreira, P.I.; Zhu, X.; Smith, M.A.; Perry, G.. "Staying connected: Synapses in alzheimer disease". American Journal of Pathology 165 5 (2004): 1461-1464. http://www.scopus.com/inward/record.url?eid=2-s2.0-7244252913&partnerID=MN8TOARS.
  229. Moreira, P.I.; Smith, M.A.; Zhu, X.; Santos, M.S.; Oliveira, C.R.; Perry, G.. "Therapeutic potential of oxidant mechanisms in Alzheimer's disease". Expert Review of Neurotherapeutics 4 6 (2004): 995-1004. http://www.scopus.com/inward/record.url?eid=2-s2.0-8344235899&partnerID=MN8TOARS.
    10.1586/14737175.4.6.995
  230. Liu, Q.; Xie, F.; Siedlak, S.L.; Nunomura, A.; Honda, K.; Moreira, P.I.; Zhua, X.; Smith, M.A.; Perry, G.. "Neurofilament proteins in neurodegenerative diseases". Cellular and Molecular Life Sciences 61 24 (2004): 3057-3075. http://www.scopus.com/inward/record.url?eid=2-s2.0-12144265815&partnerID=MN8TOARS.
    10.1007/s00018-004-4268-8
  231. Moreira, P.I.; Santos, M.S.; Moreno, A.M.; Proença, T.; Seiça, R.; de Oliveira, C.R.. "Effect of streptozotocin-induced diabetes on rat brain mitochondria". Journal of Neuroendocrinology 16 1 (2004): 32-38. http://www.scopus.com/inward/record.url?eid=2-s2.0-0742324515&partnerID=MN8TOARS.
    10.1111/j.1365-2826.2004.01107.x
  232. Moreira, P.I.; Custódio, J.B.; Oliveira, C.R.; Santos, M.S.. "Hydroxytamoxifen protects against oxidative stress in brain mitochondria". Biochemical Pharmacology 68 1 (2004): 195-204. http://www.scopus.com/inward/record.url?eid=2-s2.0-2942568021&partnerID=MN8TOARS.
    10.1016/j.bcp.2004.03.019
  233. Moreira, P.I.; Santos, M.S.; Moreno, A.M.; Seiça, R.; Oliveira, C.R.. "Increased vulnerability of brain mitochondria in diabetic (goto-kakizaki) rats with aging and amyloid-ß exposure". Diabetes 52 6 (2003): 1449-1456. http://www.scopus.com/inward/record.url?eid=2-s2.0-0038321341&partnerID=MN8TOARS.
    10.2337/diabetes.52.6.1449
  234. Pereira, C.; Agostinho, P.; Moreira, P.I.; Duarte, A.I.; Santos, M.S.; Oliveira, C.R.. "Neuroprotection strategies: Effect of vinpocetinein in vitro oxidative stress models | Estratégias de neuroprotecção: Efeito da vimpocetina em modelos in vitro de stresse oxidativo". Acta Medica Portuguesa 16 6 (2003): 401-406. http://www.scopus.com/inward/record.url?eid=2-s2.0-9644310235&partnerID=MN8TOARS.
  235. Moreira, P.I.; Santos, M.S.; Moreno, A.; Rego, A.C.; Oliveira, C.. "Effect of amyloid ß-peptide on permeability transition pore: A comparative study". Journal of Neuroscience Research 69 2 (2002): 257-267. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037100213&partnerID=MN8TOARS.
    10.1002/jnr.10282
  236. Moreira, P.I.; Santos, M.S.; Moreno, A.; Oliveira, C.. "Amyloid ß-peptide promotes permeability transition pore in brain mitochondria". Bioscience Reports 21 6 (2001): 789-800. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035780141&partnerID=MN8TOARS.
    10.1023/A:1015536808304
  237. Santos, M.S.; Duarte, A.I.; Moreira, P.I.; Oliveira, C.R.. "Synaptosomal response to oxidative stress: Effect of vinpocetine". Free Radical Research 32 1 (2000): 57-66. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033988559&partnerID=MN8TOARS.
  238. Moreira, P.; Pereira, C.; Santos, M.S.; Oliveira, C.. "Effect of zinc ions on the cytotoxicity induced by the amyloid ß- peptide". Antioxidants and Redox Signaling 2 2 (2000): 317-325. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033949740&partnerID=MN8TOARS.
  239. Pereira, C.; Moreira, P.; Seiça, R.; Santos, M.S.; Oliveira, C.R.. "Susceptibility to ß-amyloid-induced toxicity is decreased in Goto- Kakizaki diabetic rats: Involvement of oxidative stress". Experimental Neurology 161 1 (2000): 383-391. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034051172&partnerID=MN8TOARS.
    10.1006/exnr.1999.7270
  240. Moreira, Paula; Pereira, Claudia; Santos, Maria S.; Oliveira, Catarina. "Effect of Zinc Ions on the Cytotoxicity Induced by the Amyloid beta-Peptide". Antioxidants & Redox Signaling 2 2 (2000): 317-325. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000207500700014&KeyUID=WOS:000207500700014.
    10.1089/ars.2000.2.2-317
Journal issue
  1. Moreira, PI; George Perry; Jesus Avila; Aaron Serensen; Massimo Tabaton. "Preface: Alzheimer's Disease: New Beginnings". Journal of Alzheimer s Disease 64 1 (2018): https://content.iospress.com/journals/journal-of-alzheimers-disease/64/s1.
    Published • 10.1111/nyas.1982.396.issue-1
  2. Moreira, P.I.. "Mini-Symposium: Energy Demand and Energy Supply in Alzheimer’s Disease - Introduction". Brain Pathology 26 5 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84988637950&partnerID=MN8TOARS.
    10.1111/bpa.12398
Newspaper article
  1. Resende, Rosa; Silva, Ana; Cláudia Maria Fragão Pereira (PhD); Moreira, Paula Isabel; Santos, Armanda E; Cruz, Maria Teresa; Fernandes, Tânia; et al. "Doenças neurodegenerativas: um quebra-cabeças com solução à vista", O Público, 2021
  2. Ramalho-Santos, João; Varela Amaral, Sara; Álvaro, Ana Rita ; Rego, Ana Cristina; Carvalho, Ana Luisa; Barros-Viegas, Ana Teresa; Cavadas, Claudia; et al. "Viagens sem Insónias", Jornal "O Público", 2018, http://www.cnbc.pt/docs/andrecaetano_layout_BD_SONO_2018__pt.pdf.
Thesis / Dissertation
  1. Moreira, Paula; Santos, Maria; Carvalho, Cristina Isabel Marques Maurício de. "The interplay between vascular and mitochondrial abnormalities in type 2 diabetes and Alzheimer's disease". PhD, 2013. http://hdl.handle.net/10316/23526.
  2. Moreira, PI. "Mitochondrial dysfunction in Alzheimer's disease and diabetes : effect of compounds with antioxidant properties". PhD, Universidade de Coimbra Faculdade de Medicina, 2007. http://hdl.handle.net/10316/7501.
  3. Moreira, PI. "Effect of the amyloid beta peptide on the permeability transition pore: a comparative study". Master, Universidade de Coimbra - Faculdade de Ciências e Tecnologia, 2002.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2023/03/17 O inibidor da WWOX Zfra1-31 melhora a função cognitiva e a disfunção das mitocôndrias de cérebros de ratinhos com diabetes tipo 2 19th Meeting of Portuguese Society for Diabetes
Sociedade Portuguesa de Diabetologia (Vilamoura, Portugal)
2023/01/25 WWOX: a new therapeutic target in Type 2 diabetes-associated neurodegeneration DCV - Talks
Universidade de Coimbra, Faculdade de Ciências e Tecnologia (Coimbra, Portugal)
2022/11/12 WWOX inhibition by Zfra1-31 ameliorates brain mitochondrial dysfunction and oxidative stress in a mouse model of type 2 diabetes 2nd International Meeting of the Portuguese Society of Physiology
Sociedade Portuguesa de Fisiologia (Coimbra, Portugal)
2022/07/18 Metabolic Defects in Alzheimer's Disease International Research Conference on Neurodegenerative Diseases
Global Association for the Study of Neurodegenerative Diseases (Omaha, United States)
2022/06/08 Untangling the protective role of Zfra 1-31 peptide against type 2 diabetes-associated brain damage: preliminary results of a pilot study 56th Annual Scientific Meeting European Society for Clinical Investigation
European Society for Clinical Investigation (Bari, Italy)
2022/05/25 Diabetes and Alzheimer's disease crosstalk Nova Medical School Seminars
Faculdade de Ciências Médicas, Universidade Nova de Lisboa (Lisboa, Portugal)
2022/04/22 Impaired insulin and IGF-1 signaling affects brain mitochondria and redox homeostasis Spanish Symposium on IGFs and Insulin 2022: Implications in Physiology and Disease
(Logroño, Spain)
2022/03/10 A inibição da proteína WWOX protege a mitocôndria e previne a morte de neurónios expostos a níveis elevados de glicose 18th Meeting of Portuguese Society for Diabetes
Sociedade Portuguesa de Diabetologia (Vilamoura, Portugal)
2021/11/18 Structural and functional alterations in mitochondria-associated membranes (MAMs) in an in vitro model of Alzheimer's disease 2º Retiro do Grupo de Metabolismo, Envelhecimento e Doença (MAD) do Centro de Inovação em Biomedicina e Biotecnologia (CIBB)
(Coimbra, Portugal)
2021/09/11 N-Carboxymethyl lysine induces mitochondrial-associated defects in differentiated SH-SY5Y neuroblastoma cells 55th Annual Scientific Meeting - ESCI Virtual 2021
European Society for Clinical Investigation
2021/07/27 Neuroprotective effect of Zfra 1-31 peptide against high glucose-induced mitochondrial dynamics and autophagy alterations 57th EASD Annual Meeting European Society for the study of diabetes 2021
European Association for the Study of Diabetes
2021/07/19 Zfra 1-31 prevents high glucose-induced neuronal death through improvement of mitochondrial and autophagy defects International Conference on Diabetes and Endocrinology. Coalesce Research Group
(Online)
2021/07/02 Alzheimer disease beyond amyloid: a preclinical perspective 35ª REUNIÃO ANUAL DO GEECD - Inovação em Doença de Alzheimer
GEECD - Grupo de Estudos em Envelhecimento Cerebral e Demência (Coimbra, Portugal)
2021/06/10 Hypoxia preconditioning-triggered mitochondrial remodeling in a rat model of sporadic Alzheimer's disease: a "breath of fresh air" 55th Annual Scientific Meeting of the European Society for Clinical Investigation
European Society for Clinical Investigation (Online)
2021/06/09 Physical and biochemical alterations in endoplasmic reticulum-mitochondria contacts in an Alzheimer's disease in vitro model 55ª Reunião científica anual da Sociedade Europeia para a Investigação Clínica (ESCI)
European Society for Clinical Investigation (Webinar)
2021/06/06 UCP2 inhibition modulates cognition and brain mitochondrial function under different metabolic insults 55th Annual Scientific Meeting of the European Society for Clinical Investigation - ESCI2021
European Society for Clinical Investigation (On line)
2021/06/06 WWOX inhibition in neuronal cells exposed to high glucose ameliorates mitochondrial dynamics and autophagy preventing cell death 55th Annual Scientific Meeting - ESCI Virtual 2021
European Society for Clinical Investigation
2021/06/03 Loss of HUMMR as a potential 'roadblock' for mitochondrial movement in Alzheimer's disease 35th Meeting of the Portuguese Group of Studies on Aging and Dementia GEECD
GEECD - Grupo de Estudos em Envelhecimento Cerebral e Demência (Webinar)
2021/04/26 Mitochondrial dysfunction and oxidative stress in Alzheimer's disease Redox Webinar Series - Crosstalk between oxidative stress and metabolic defects: implications for Alzheimer's disease
Faculty of Pharmacy and Medicine, Sapienza University of Rome (Rome, Italy)
2020/09/26 Hypoxic precoditioning averts sporadic Alzheimer's disease-like phenotype in rats: the role of mitochondrial remodeling 34th Meeting of the Portuguese Group of Studies on Aging and Dementia GEECD
GEECD - Grupo de Estudos em Envelhecimento Cerebral e Demência (Portugal)
2020/09/26 Structural and functional alterations in endoplasmic reticulum-mitochondria contacts in Alzheimer's disease in vitro models 34ª Reunião do Grupo de Estudos de Envelhecimento Cerebral e Demência (GEECD)
GEECD - Grupo de Estudos em Envelhecimento Cerebral e Demência (Webinar, Portugal)
2020/02/06 Changes in the Protein Composition of Mitochondrial-Associated Membranes (MAMs) in Alzheimer's Disease 50ª Reunião da Sociedade Portuguesa de Farmacologia
Sociedade Portuguesa de Farmacologia (Coimbra, Portugal)
2019/05 Hypoxic preconditioning: a strategy to fight Alzheimer’s disease?
European Society of Clinical Investigation (Coimbra, Portugal)
2018/03 Mitochondrial dysfunction and energy failure in Alzheimer’s disease Focused Symposium “Bioenergetics and neurodegenerative disorders: moving from pathogenesis to therapeutics”; Advances in Neuroscience for Medical Advance
Centre for Therapeutic Innovation in Neuropsychiatry, Institut de Recherches Servier (France)
2016/06/04 Alzheimer's disease: mechanistic insights and biomarkers discovery 30ª Reunião do Grupo de Estudos de Envelhecimento Cerebral e Demência
(Lisboa, Portugal)
2016 Alzheimer's disease: focus on mitochondria Seminars_IBILI
(Coimbra, Portugal)
2015/10 The efficacy of the antidiabetic drug liraglutide in Alzheimer’s disease-like pathology 6th Annual Alliance for Healthy Ageing: Interventions to Slow Down Aging
(Newcastle, United Kingdom)
2015/03 Insulin signaling as a bridge between diabetes and Alzheimer’s disease Gordon Research Conference - IGF & Insulin System in Physiology & Disease
(California, United States)
2014/07 Mitochondria take center stage in Alzheimer’s disease 18th European BioEnergetics Conference – EBEC 2104
(Lisboa, Portugal)
2014/04 Etiologia e fisiopatologia das doenças neurodegenerativas Ciclo de Palestras em Atividade Física e Saúde “Exercício, Saúde e Sociedade
CIAFEL - Universidade do Porto (Porto, Portugal)
2014 A diabetes tipo 2 e a doença de Alzheimer Jornadas de Análises Clínicas e Saúde Pública – Reunião Anual 2014
Escola Superior de Tecnologia da Saúde de Coimbra (Coimbra, Portugal)
2013 Mitochondrial crossroad in Alzheimer’s disease 47th Annual Scientific Meeting of the European Society for Clinical Investigation
(Albufeira, Portugal)
2011 Mitochondria and the Vasculature 7th International Congress on Vascular Dementia
(Riga, Latvia)
2010/11/22 Alzheimer’s disease: research tools and therapeutic perspectives Palestras do Núcleo de Estudantes de Bioquímica
Núcleo de Estudantes de Bioquímica (Coimbra, Portugal)
2010/05/03 Mitochondria, diabetes and Alzheimer’s disease Seminars on neuropharmacology and functional imaging II: integrating mitochondria, diabetes and neurodegeneration
Universidade do Porto (Porto, Portugal)
2009/07 A disfunção mitocondrial na doença de Alzheimer II Jornadas de Bioquímica da UTAD
Universidade de Trás-os-Montes e Alto Douro (Vila Real, Portugal)
2008/07 A mitocôndria, um catalizador do envelhecimento cerebral e da demência Ciência 2008 – Encontro com a Ciência em Portugal Promovido pelos Laboratórios Associados
Fundação Calouste Gulbenkian (Lisboa, Portugal)
2007/11/08 Diabetes is a risk factor for Alzheimer disease: the role of mitochondria 5th International Congress on Vascular Dementia
(Budapeste, Hungary)
2007/11 O papel da mitocôndria na doença de Alzheimer 1º Congresso Científico de Saúde: Doenças Neurodegenerativas
Faculdade de Farmácia da Universidade de Lisboa (Lisboa, Portugal)
2007/04/28 Liver mitochondria isolated from ovariectomized and tamoxifen-treated ovariectomized rat females are affected by estradiol 1st Iberic Meeting on Medicinal Chemistry: Anticancer Agents – 1IMMC
(Régua, Portugal)
2006/12/08 Tamoxifen and estradiol: a deadly combination for cancer cells XV National Congress of Biochemistry
Sociedade Portuguesa de Bioquímica (Aveiro, Portugal)
2006/07 Mitochondrial autophagocytosis in Alzheimer disease 10th International Conference on Alzheimer´s Disease and Related Disorders
(Madrid, Spain)
2006/03 Tamoxifen and estradiol lead to mitochondrial complex I failure International Courses on Toxicology “Smart Toxicology: Subcellular Targets of Anti-Cancer Therapy”
Universidade de Coimbra, Centro de Neurociencias e Biologia Celular
2006 Oxidative Stress in Alzheimer disease: role of antioxidants 4th International Congress on the Improvement of the Quality of Life in Dementia, Epilepsy, MS and Peripheral Neuropathies
(Odessa, Ukraine)
2005/10 Brain mitochondria as a link between Alzheimer’s disease and diabetes 4th International Congress on Vascular Dementia
(Porto, Portugal)
2005/07/03 Brain mitochondrial dysfunction is a common feature in both diabetes and Alzheimer’s disease 19ª Reunião do grupo de estudos do envelhecimento cerebral e demência
(Tomar, Portugal)
2005/04 Effect of amyloid beta-peptide on brain mitochondria isolated from diabetic rats Mitochondria: Between Life and Death – International Courses on Toxicology
(Coimbra, Portugal)
2003/12/15 Diabetes and Alzheimer’s Disease: Are Brain Mitochondria a Link Between Both Pathologies? 1º Workshop de Bioquímica Clínica
(Porto, Portugal)
2003/12 Role of Insulin in Brain Mitochondria Status of Type 1 Diabetic Rats. Does Amyloid beta-Peptide Interferes with Mitochondrial Function? 16st Luso-Spanish Congress on Free Radicals / 6th Portuguese Congress on Free Radicals in Chemistry, Biology and Medicine
2002/07/14 Bioenergética mitocondrial e o envelhecimento 16ª Reunião-Grupo de Estudos – Envelhecimento Cerebral e Demência
2001 Mitochondria: a target for beta-amyloid peptide XXXII Reunião Anual da Sociedade Portuguesa de Farmacologia e XX Reunião de Farmacologia Clínica
(Coimbra, Portugal)
2000/07/02 Mitocôndria e o envelhecimento: efeito do peptídeo Abeta25-35 14ª Reunião - Grupo de Estudos: Envelhecimento Cerebral e Demência

Supervision

Thesis Title
Role
Degree Subject (Type)
Institution / Organization
2023 - Current WWOX e complicações cardíacas na diabetes tipo 2
Co-supervisor
Mestrado Integrado em Medicina (Master)
Universidade de Coimbra - Faculdade de Medicina, Portugal
2020 - 2024 Lipidomic fingerprint of MAMs in Alzheimer's disease - impact of its modulation on neuronal metabolism
Supervisor
Ciências Biomédicas (PhD)
Universidade de Coimbra - Faculdade de Medicina, Portugal
2019 - 2023 Rational drug design of novel potent multifunctional agents for Alzheimer´s disease treatment
Co-supervisor
Ciências Farmacêuticas (PhD)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2013 - 2022 Exendin-4 therapy in Alzheimer´s disease and diabetic brain: effect in mitochondria and insulin-mediated pathways
Co-supervisor
Biologia Experimental e Biomedicina (PhD)
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2016 - 2017 O-GlcNAcylation represents a "sweet" route to tackle Alzheimer's disease-related phenotype
Supervisor
Biologia Celular e Molecular (Master)
Universidade de Coimbra - Faculdade de Ciências e Tecnologia, Portugal
2016 - 2017 Neuronal energy status and Alzheimer’s disease: searching for a connection
Supervisor
Bioquímica (Master)
Universidade de Coimbra - Faculdade de Ciências e Tecnologia, Portugal
2015 - 2016 Protective effects of hypoxic preconditioning against sporadic Alzheimer’s disease-like pathology - focus on insulin signaling, mitochondrial dynamics and autophagy
Supervisor
Mestrado Integrado em Medicina (Master)
Universidade de Coimbra - Faculdade de Medicina, Portugal
2014 - 2015 Effects of vitamin D deficient and high-fat diets in the diabetic brain: focus on insulin signaling
Supervisor
Bioquímica (Master)
Universidade de Coimbra - Faculdade de Ciências e Tecnologia, Portugal
2011 - 2015 Role of endoplasmic reticulum stress in the cross-talk between neurons and brain endothelial cells - Implications for Alzheimer's disease
Supervisor
Ciências Biomédicas (PhD)
Universidade de Coimbra - Faculdade de Medicina, Portugal
2013 - 2014 Brain endothelial cells protection by pinacidil preconditioning in an okadaic acid-induced Alzheimer’s disease model: role of mitoKATP channels, ROS and HIF-1a
Supervisor
Biologia Celular e Molecular (Master)
Universidade de Coimbra - Faculdade de Ciências e Tecnologia, Portugal
2013 - 2014 Effect of the Daily Consumption of White Tea in the Cerebral Cortex of Prediabetic Rats
Co-supervisor
Ciências Biomédicas (Master)
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2011 - 2013 Efeitos do metilglioxal e da piridoxamina na bioenergética e no estado redox de mitocôndrias de cérebro de rato
Supervisor
Mestrado Integrado em Medicina (Master)
Universidade de Coimbra - Faculdade de Medicina, Portugal
2010 - 2013 Deciphering the role of mitochondria and uncoupling proteins in hypoglycemia- and/or hyperglycemia-induced brain injury
Supervisor
Biologia Celular (PhD)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2010 - 2013 Diabetes-associated endothelium dysfunction: a cause of neurodegeneration? The role of brain endothelial mitochondria
Supervisor
Biologia (PhD)
Universidade de Coimbra - Faculdade de Ciências e Tecnologia, Portugal
2010 - 2013 Impact of diabetes and insulin in the selective degradation of brain mitochondria by mitophagy
Supervisor
Biologia (PhD)
Universidade de Coimbra - Faculdade de Ciências e Tecnologia, Portugal
2009 - 2012 Role of mitochondria in the regulation of factor hypoxia-inducible factor-1 in brain endothelium under diabetic conditions
Supervisor
Biologia (PhD)
Universidade de Coimbra - Faculdade de Ciências e Tecnologia, Portugal
2010 - 2011 Effect of age and chronic hypoxia on oxidative status, mitochondria and apoptosis in rat liver
Supervisor
Bioquímica (Master)
Universidade de Coimbra - Faculdade de Ciências e Tecnologia, Portugal
2009 - 2010 Effects of Aß1-40 and 17ß-estradiol on brain mitochondrial oxidative stress and damage
Supervisor
Biologia
Universidade de Coimbra - Faculdade de Ciências e Tecnologia, Portugal
2007 - 2008 Efeito da metformina na bioenergética mitocondrial e no stresse oxidativo
Supervisor
Biologia Celular (Master)
Universidade de Coimbra - Faculdade de Ciências e Tecnologia, Portugal

Event organisation

Event name
Type of event (Role)
Institution / Organization
2023/04/03 - 2023/04/13 ONE HEALTH: A Metabolic Approach from the Cell to Society Advanced Course - PHD Programme in Experimental Biology and Biomedicine (2023)
Other (Co-organisor)
Universidade de Coimbra - Centro de Neurociências e Biologia Celular, Portugal
2022/04/04 - 2022/04/08 Advanced Course "Metabolic and inflammatory drivers in age-related neurodegenerative diseases" (2022/04/04)
Other (Co-organisor)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2019/05/23 - 2019/05/24 Symposium - Neurobiology of Aging; 53rd Annual Scientific Meeting of the European Society for Clinical Investigation (2019 - 2019)
Symposium
European Society for Clinical Investigation, Netherlands
2019/04/08 - 2019/04/12 Advanced Course - Neurodegenerative Disorders PhD Programme in Experimental Biology and Biomedicine (2019 - 2019)
Other (Co-organisor)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2013/02/25 - 2013/03/01 Advanced Course - Neurobiology and Disease Doctoral Programme in Health Sciences (2013 - 2013)
Other (Co-organisor)
Universidade de Coimbra - Faculdade de Medicina, Portugal
2012/12/10 - 2012/12/14 Advanced Course - Biology of Proteolysis in Pathology; PhD Programme in Experimental Biology and Biomedicine (2012 - 2012)
Other (Co-organisor)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Event participation

Activity description
Type of event
Event name
Institution / Organization
2022/07/18 - 2022/07/18 Session chair - International Research Conference on Neurodegenerative Diseases
Conference
International Research Conference on Neurodegenerative Diseases

Jury of academic degree

Topic
Role
Candidate name (Type of degree)
Institution / Organization
2024/01/31 SC-Nanophytosomes to address neurodegenerative diseases challenge: a novel concept of mitochondria-targeted therapy.
(Thesis) Main arguer
Daniela Sofia Gonçalves Mendes (PhD)
Universidade do Porto Faculdade de Farmácia, Portugal
2023/10 Hippocampal lipid droplets and the gut microbiome: effects of type 2 diabetes and exercise Gezime Seferi (PhD)
Oslo universitetssykehus, Norway
2021 Role of TOMM40'523 - APOE haplotypes in Alzheimer's disease etiology - from clinics to mitochondria
(Thesis) Arguer
Remy Cardoso (PhD)
Universidade NOVA de Lisboa NOVA Medical School, Portugal
2020 Brain energy and neurotransmitter metabolism in the 5xFAD mouse model of Alzheimer's disease
(Thesis) Main arguer
Jens Velde Andersen (PhD)
IT-Universitet i København, Denmark
2019 Targeting Hsp70 in Huntington's disease
(Thesis) Main arguer
Sara Daniela de Sousa Reis (PhD)
Universidade do Porto Faculdade de Farmácia, Portugal
2019 Physical exercise as a preventive and therapeutic strategy against behavioral dysfunction in Alzheimer’s disease
(Thesis) Main arguer
Telma Bernardo (PhD)
Universidade do Porto Faculdade de Desporto, Portugal
2019 Decoding the interplay between TAZ and metabolism in early lung development
(Thesis) Main arguer
Henrique Silva (Master)
Universidade do Minho Escola de Medicina, Portugal
2018 Deregulated inflammasome in Bipolar Disorder (BD): a matter of stress?
(Thesis) Main arguer
Ana Catarina de Jesus Pais Pereira (Master)
Universidade de Coimbra - Faculdade de Ciências e Tecnologia, Portugal
2018 The role of beclin 1 deacetylation on autophagic flux in Alzheimer´s disease
(Thesis) Main arguer
Filipa Isabel Parreiras Filipe (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2017 Evaluation of neuroprotective and neurotoxic functions of diferente microglia phenotypes in Alzheimer’s disease onset and progression, using in vitro and in vivo models
(Thesis) Arguer
Cláudia Alexandra Oliveira Lopes Caldeira (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2017 Biological effects of new BACE1 inhibitors for Alzheimer´s disease treatment
(Thesis) Main arguer
Verónica Resende Figueiredo (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2017 Autophagy in Neurodegeneration: Latest developments on eating ourselves out of disease
(Thesis) Main arguer
Pedro Xavier Pinto Figueiredo (Master)
Universidade de Coimbra - Faculdade de Medicina, Portugal
2016 Novas abordagens terapêuticas para os fármacos baseados nas incretinas
(Thesis) Main arguer
Ana Luísa Vieira da Natividade Faria João (Master)
Universidade de Coimbra - Faculdade de Medicina, Portugal
2015 Modulation of neuronal mitochondrial dynamics, autophagy and huntingtin proteostasis by HDAC inhibitors: Insights for Huntington's disease
(Thesis) Main arguer
Pedro Gonçalo Guedes Dias (PhD)
Universidade do Porto Faculdade de Farmácia, Portugal
2015 Sirtuin 2 in hypothalamus: an emerging target in insulin resistance?
(Thesis) Main arguer
Liliana Isabel Fernandes dos Santos (Master)
Universidade de Coimbra - Faculdade de Ciências e Tecnologia, Portugal
2014 Chronic exercise mitigates doxorubicin-induced cardiac and brain mitochondrial liabilities. Effects on mitochondrial activity, oxidative stress, apoptotic signaling, mitochondrial dynamics and quality control
(Thesis) Main arguer
Inês Sofia Marques Aleixo (PhD)
Universidade do Porto Faculdade de Desporto, Portugal
2014 Insulin signalling depends on the endocannabinoid system in the brain
(Thesis) Main arguer
Carla Sofia da Silva Santos (Master)
Universidade de Coimbra - Faculdade de Ciências e Tecnologia, Portugal
2013 Transthyretin as a signaling molecule: influence on IGF-IR pathway and 14-3-3-¿ metabolism
(Thesis) Main arguer
Marta Virgínia Mota Vieira (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2013 Impact of H9c2 Cardiomyoblasts Differentiation on Isoproterenol Toxicity: Different Modulation of Signaling Pathways
(Thesis) Arguer
Ana Filipa Roque Branco (PhD)
Universidade de Coimbra - Faculdade de Ciências e Tecnologia, Portugal
2013 Bioenergética do músculo esquelético na doença de Alzheimer
(Thesis) Main arguer
Marisa Alexandra Torres de Castro (Master)
Universidade de Trás-os-Montes e Alto Douro, Portugal
2013 Autophagy in cortical neurons: role of caloric restriction and neuropeptide Y
(Thesis) Main arguer
Marisa Ferreira Marques (Master)
Universidade de Coimbra - Faculdade de Ciências e Tecnologia, Portugal
2013 Evaluation of a dipeptidyl peptidase IV inhibitor as a microvascular protector in diabetes
(Thesis) Main arguer
Maria Luísa Morais de Almeida (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2013 The multifaceted role of the endocannabinoid system in the regulation of cerebral glucose uptake
(Thesis) Main arguer
Ana Bárbara da Silva Pinheiro (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2013 Papel do exercício físico na disfunção endotelial
President of the jury
Papel do exercício físico na disfunção endotelial (Master)
Universidade de Coimbra - Faculdade de Medicina, Portugal
2013 Efeito da berberina na sensibilidade à insulina num modelo animal de diabetes tipo 2
President of the jury
Daniel Tavares Rego (Master)
Universidade de Coimbra - Faculdade de Medicina, Portugal
2013 Complicações macromoleculares da diabetes tipo 2: papel dos AGEs e do RAGE
President of the jury
Daniela Sofia Lourenço Neto (Master)
Universidade de Coimbra - Faculdade de Medicina, Portugal
2013 O papel da piridoxamina na reversão da lesão renal induzida por metilglioxal
President of the jury
Adriana Isabel Dias Roque (Master)
Universidade de Coimbra - Faculdade de Medicina, Portugal
2012 Sucrose-induced memory deficits
(Thesis) Main arguer
Edna Filipa Pais Soares (Master)
Universidade de Coimbra - Faculdade de Ciências e Tecnologia, Portugal
2011 O sistema somatossensitivo no rato com neuropatia diabética
(Thesis) Main arguer
Carla Sofia da Costa Morgado (PhD)
Universidade do Porto Faculdade de Medicina, Portugal
2008 Neurotoxicity induced by amyloid-beta: the role of different peptide assemblies
(Thesis) Arguer
Rosa Maria Branco de Matos Resende (PhD)
Universidade de Coimbra - Faculdade de Medicina, Portugal

Association member

Society Organization name Role
2022 - Current Portuguese Physiological Society Member
2007 - Current Portuguese Society of Diabetology Membro
2007 - Current European Association for the Study of Diabetes Membro
2006 - Current Portuguese Society for Neuroscience Membro

Committee member

Activity description
Role
Institution / Organization
2022/07/18 - 2022/07/19 IRCND 2022 Long Range Planning Committee
Member
2019/05/22 - 2019/05/24 Scientific committee - 53rd Annual Meeting of the European Society for Clinical Investigation (ESCI)
Member
European Society for Clinical Investigation, Netherlands
2018/07/13 - 2018/07/13 Scientific Committee - International Symposium; MitoPorto – Mitochondrial evolution, metabolism and disease
Other
2013/05/30 - 2013/06/01 Organizing committee - XIII Reunião da Sociedade Portuguesa de Neurociências
Member

Conference scientific committee

Conference name Conference host
2022/07/01 - 2022/07/02 36ª Reunião Anual do Grupo de Estudos de Envelhecimento Cerebral e Demência

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2024 - Current Fundamentos de Fisiologia II - Curricular Unit Coordinator (Regência) Medicinal Chemistry Degree Fundamentos de Fisiologia II Universidade de Coimbra - Faculdade de Medicina, Portugal
2023 - Current Fundamentos de Fisiologia I - Curricular Unit Coordinator (Regência) Medicinal Chemistry Degree Fundamentos de Fisiologia I (Licenciatura) Universidade de Coimbra - Faculdade de Ciências e Tecnologia, Portugal
2020/05 - Current Fisiologia II (Master Universitario) Universidade de Cabo Verde, Cape Verde
2012 - Current Fundamentos de Fisiologia II Licenciatura em Química Medicinal (Licenciatura) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2011/02 - Current Fisiologia Humana Geral Mestrado Integrado em Medicina Dentária (Mestrado integrado) Universidade de Coimbra - Faculdade de Medicina, Portugal
2011 - Current Fundamentos de Fisiologia I Licenciatura em Química Medicinal (Licenciatura) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2009 - Current Fundamentos de Fisiologia II Mestrado Integrado em Engenharia Biomédica (Mestrado integrado) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2008 - Current Fundamentos de Fisiologia I Mestrado Integrado em Engenharia Biomédica (Mestrado integrado) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2006/02 - Current Fisiologia II (Mestrado integrado) Universidade de Coimbra - Faculdade de Medicina, Portugal
2005/12/01 - Current Fisiologia I Mestrado Integrado em Medicina (Mestrado integrado) Universidade de Coimbra - Faculdade de Medicina, Portugal
2023/04/03 - 2023/04/13 PHD Programme in Experimental Biology and Biomedicine - PDBEB ONE HEALTH: A Metabolic Approach from the Cell to Society (Curso de doutoramento (conclusão de unidades curriculares)) Universidade de Coimbra - Centro de Neurociências e Biologia Celular, Portugal

Evaluation committee

Activity description
Role
Institution / Organization Funding entity
2022 - Current 2023 Pasqual Maragall Alzheimer Researchers Programme (PMRP)
Evaluator
Generalitat de Catalunya Agència de Gestió d'Ajuts Universitaris i de Recerca, Spain
2016 - Current Evaluator for European Science Foundation
Evaluator
European Science Foundation, France
2024 - 2024 ERA4Health NutriBrain Joint Transnational Call MUR - Ministero dell'Università e della Ricerca, Italy
2021 - 2021 Evaluator of the reports submitted by Doctorate Researchers (Decreto-Lei n.º 57/2016)
Evaluator
Faculty of Medicine, University of Coimbra, Portugal
2016 - 2021 Evaluator of the Marie Sklodowska-Curie Individual Fellowships (Life Sciences Panel)
Evaluator
European Commission, Belgium European Commission
2016 - 2021 Evaluator of applications - Alzheimer's Association Research Grant Program
Evaluator
Alzheimer's Association, United States Alzheimer's Association
2019/12 - 2020/12 Committee Member on Novo Nordisk Foundation Challenge Programme 2020 - Biomedicine and Health Sciences
Evaluator
Novo Nordisk Fonden, Denmark Novo Nordisk Fonden
2018 - 2018 Evaluator of applications within the call "What causes Brain Disease?"
Evaluator
Lundbeckfonden, Denmark Lundbeckfonden
2016 - 2018 Evaluator of applications submitted to ANR Agence nationale de la recherche, France Agence nationale de la recherche
2014 - 2015 Evaluator Post-Doctoral Fellowships (Experimental Biology and Biochemistry Panel)
Evaluator
Fundação para a Ciência e a Tecnologia, I.P. (Lisbon, Portugal), Portugal Fundação para a Ciência e a Tecnologia, I.P. (Lisbon, Portugal)

Journal scientific committee

Journal title (ISSN) Publisher
2020/05 - Current Antioxidants & Redox Signaling (1557-7716) Mary Ann Liebert
2018 - Current Journal of Alzheimer's Disease Reports IOS Press
2018 - Current Diabetologia (1432-0428) Springer-Verlag
2018 - Current Brain Behavior and Immunity (1090-2139) Elsevier
2018 - Current Scientific Reports (2045-2322) Springer Science and Business Media LLC
2018 - Current Cellular and Molecular Life Sciences (1420-9071) Springer-Verlag
2018 - Current EClinicalMedicine (2589-5370) Elsevier
2018 - Current Nature Reviews Neurology (1759-4766) Springer Science and Business Media LLC
2018 - Current Neurotherapeutics (1878-7479) Springer-Verlag
2017 - Current Progress in Neurobiology (0301-0082) Elsevier
2017 - Current Alzheimers Disease & Dementia (2578-6490) sPage.direcT
2017 - Current American Journal of Alzheimer s Disease (1082-5207) SAGE Publications
2017 - Current Molecular Biology Reports (1573-4978) Springer-Verlag
2016 - Current Rejuvenation Research (1557-8577) Mary Ann Liebert
2016 - Current Diabetes Obesity and Metabolism (1463-1326) Wiley (Blackwell Publishing)
2016 - Current Nature Reviews Endocrinology (1759-5037) Springer Science and Business Media LLC
2016 - Current The Lancet Diabetes & Endocrinology (2213-8587) Elsevier
2015 - Current PeerJ (2167-8359) PeerJ
2015 - Current BioMed Research International (2314-6141) Hindawi Limited
2015 - Current Current Alzheimer Research (1567-2050) Bentham Science
2015 - Current Journal of Clinical Investigation (1558-8238) American Society for Clinical Investigation
2015 - Current Medicinal Research Reviews (1098-1128) Wiley (John Wiley & Sons)
2015 - Current Neuropathology and Applied Neurobiology (1365-2990) Wiley (Blackwell Publishing)
2015 - Current Expert Opinion on Drug Discovery (1746-045X) Informa UK (Taylor & Francis)
2015 - Current Molecular Neurobiology (0893-7648) Springer-Verlag
2015 - Current Trends in Neurosciences (0166-2236) Elsevier
2014 - Current Therapeutic Advances in Chronic Disease (2040-6231) SAGE Publications
2014 - Current Neuropharmacology (0028-3908) Elsevier
2014 - Current Aging Cell (1474-9728) Wiley (Blackwell Publishing)
2014 - Current Trends in Biotechnology (0167-7799) Elsevier
2013 - Current Expert Reviews in Molecular Medicine (1462-3994) Cambridge University Press
2012 - Current Frontiers in Aging Neuroscience (1663-4365) Frontiers Media SA
2012 - Current Diabetes
2012 - Current Neurobiology of Disease (1095-953X) Elsevier
2012 - Current Neurobiology of Disease (1095-953X) Elsevier
2012 - Current Free Radical Biology and Medicine (0891-5849) Elsevier
2012 - Current Neuroendocrinology (1423-0194) S. Karger AG
2012 - Current Biochemical Pharmacology (0006-2952) Elsevier
2012 - Current Journal of Neurochemistry (1471-4159) Wiley (Blackwell Publishing)
2010 - Current Journal of Alzheimer s Disease (1875-8908) IOS Press
2010 - Current Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (0925-4439) Elsevier
2010 - Current European Journal of Pharmacology (0014-2999) Elsevier
2009 - Current Antioxidants & Redox Signaling (1557-7716) Mary Ann Liebert
2009 - Current European Journal of Clinical Investigation (1365-2362) Wiley (Blackwell Publishing)
2009 - Current Neurosciences (1658-3183) Neurosciences
2008 - Current The FASEB Journal (1530-6860) Federation of American Society for Experimental Biology
2005 - Current Experimental Neurology (1090-2430) Elsevier
2004 - Current Expert Review of Neurotherapeutics (1744-8360) Informa UK (Taylor & Francis)
2013 - 2019 British Journal of Pharmacology (1476-5381) Wiley (Blackwell Publishing)
Distinctions

Award

2023 Rosalind Franklin Society Special Award in Science 2022
Rosalind Franklin Society , United States

Mary Ann Liebert Inc., United States
2023 Honorable Mention Pedro Eurico Lisboa / SPD
Sociedade Portuguesa de Diabetologia, Portugal
2017 Orlando Leitão Prize
Sociedade Portuguesa de Neurologia, Portugal
2015 Mantero Belard Prize
Santa Casa da Misericórdia de Lisboa, Portugal
2014 2nd prize for research project
Sociedade Portuguesa de Diabetologia, Portugal
2013 Best Research Paper - Basic Science
Universidade de Coimbra - Faculdade de Medicina, Portugal
2010 ASN Neuro Poster Prize
American Society of Neurochemistry, United States
2008 L'Oreal for Women in Science award
L’Oreal Portugal , Portugal

Comissão Nacional da UNESCO , Portugal

Fundação para a Ciência e a Tecnologia, Portugal
2003 Stimulus to Research Prize
Fundação Calouste Gulbenkian, Portugal
2003 Best Poster Prize
Physiological Society, United Kingdom

Title

2022 Member of Global Association for the Study of Neurodegenerative Diseases
2021 Member of the Selection Committee Top 25 Outstanding Women Listeners 2021
2021 Member of Neurodegeneration Precision Medicine Initiative
2018 Member of the Dana Alliance for Brain Initiatives
Dana Foundation, United States
2018 Member of European Science Foundation (ESF) College of Expert Reviewers
European Science Foundation, France

Other distinction

2023 Research.com_ranked #4 in Portugal among Best Scientists in Biology and Biochemistry
2023 Research.com_ranked #9 in Portugal among Best Scientists in Medicine
2022 World's Top 2% Scientists 2022
2021 Expertscape World Expert in Mitochondria
2021 World's Top 2% Scientists 2021