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After my graduation in Biotechnological Engineering in 2003, I joined the Center for Neuroscience of Coimbra (CNC, Coimbra, Portugal) to develop my MSc thesis, where I characterized the signal transduction pathways involved in the yeast’s response to several stresses. This raised yeasts as a basic model to study inflammatory/stress responses at the cellular level and to assist in the search/screening of new anti-inflammatory drugs (1 first author publication in J. Biol. Chem. and 2 co-author publications). In 2006, I joined J Lerma’s lab (Instituto de Neurociencias, Alicante, Spain) to perform my PhD in neuroscience, where I could provide the first link between activity, i.e. glutamate, and neurocytoskeleton dynamics during neuronal development, raising kainite receptor as the key tether linking synaptic contact formation and neuronal maturation. This represented a breakthrough in brain development. These results were published in J. Neuroscience (first author publication awarded with Best Paper 2014 award by Portuguese Society for Neurosciences) and reviewed in Neuron. In 2013 I joined RJ Rodrigues’ lab at CNC (Coimbra, Portugal) to explore the pathological role of purinergic and glutamate receptors in brain diseases. I contributed to determine that P2Y1R contributes to glutamate-induced neurodegeneration (Simões et al., 2018) and to synaptic and memory loss in Alzheimer’s disease models (co-first author manuscript in preparation; see Marques et al., 2017), raising the concept that this newly identified pathway may constitute a degenerative mechanism shared by different brain diseases. This work was supported by an international grant from Alzheimer’s Association (NIRG-15-361884) in which I was Co-PI. I have been also exploring the existence of hybrid P2X/GluN receptors, establishing a new receptor concept (manuscript under revision; Postdoctoral fellowship SFRH/BPD/107903/2015). I also contributed to 8 co-author publications on the physio-pathological role of purinergic signalling. I also started my transition towards my scientific independency by exploring a new line of investigation dedicated to explore brain diseases from the perspective of brain development, merging my interest/expertise in brain development (PhD) and disease (postdoc). This has been successfully accomplished, attested by the attribution of CEEC Individual 2017 (Junior level) and of my first grant as a PI (PTDC/MED-NEU/28160/2017; 238,834€). Also, I supervised 3 graduation (2015, 2018, 2019), 2 MSc thesis (2018 and 2019) and 1 on-going PhD student, and participated in teaching in post-graduate programs (e.g. GABBA PhD programme). I already constituted a small group that is presently composed by 1 senior researcher, 1 PhD and 1 MSc students. Our independent research activity supports already two manuscripts in preparation as last author (presented at SPN2019 meeting and to be presented at FENS2020 meeting) and 2 review papers (Rodrigues et al., 2019 and Mateus et al., 2020).
Identificação

Identificação pessoal

Nome completo
Joana Medeiros Vieira Marques
Data de nascimento
1977/03/03
Género
Feminino

Nomes de citação

  • Marques, Joana
  • Joana M Marques

Identificadores de autor

Ciência ID
8F1D-1D21-457C
ORCID iD
0000-0002-7234-9477
Scopus Author Id
55888289600

Endereços de correio eletrónico

  • joanammarques@gmail.com (Profissional)

Moradas

  • Center for Neuroscience and Cell Biology Faculdade de Medicina, Polo I, Rua Larga , 3004-504, Coimbra, Coimbra, Portugal (Profissional)
  • Rua General Humberto Delgado nº 127A 4º esquerdo, 3030-327, Coimbra, Coimbra, Portugal (Pessoal)

Websites

  • http://www.cnbc.pt/research/department_group_show.asp?iddep=1109&idgrp=1408&IdGrupo=1107&IdSeccao=&hash=39 (Profissional)

Domínios de atuação

  • Ciências Médicas e da Saúde - Medicina Básica - Neurociências
  • Ciências Médicas e da Saúde - Medicina Básica - Neurociências
  • Ciências Médicas e da Saúde - Medicina Básica - Neurociências
  • Ciências Médicas e da Saúde - Medicina Básica - Neurociências

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português (Idioma materno)
Inglês Utilizador proficiente (C1) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Espanhol; Castelhano Utilizador proficiente (C1) Utilizador proficiente (C2) Utilizador proficiente (C1) Utilizador proficiente (C2) Utilizador proficiente (C2)
Francês Utilizador elementar (A2) Utilizador elementar (A2) Utilizador elementar (A2) Utilizador independente (B1) Utilizador elementar (A2)
Formação
Grau Classificação
2013/10/31
Concluído
Biology (Doutoramento)
Especialização em Cell Biology
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Role of kainate receptors in neuronal development." (TESE/DISSERTAÇÃO)
Aprovada com Distinção e Louvor por Unanimidade
2006/11/02
Concluído
MSc in Celular and Molecular Biology (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Involvement of Hog1 protein in the Saccharomyces cerevisiae response to lipopolysaccharide." (TESE/DISSERTAÇÃO)
Very Good
2003/02/19
Concluído
Biotechnology Engineering (Licenciatura)
Universidade Lusófona de Humanidades e Tecnologias, Portugal
"Metabolic alterations in yeast apoptosis." (TESE/DISSERTAÇÃO)
14
Percurso profissional

Outros

Categoria Profissional
Instituição de acolhimento
Empregador
2019/04/01 - Atual CEECIND 2017 Junior Investigator (01879) FCT- Fundação para a Ciência e a Tecnologia, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2018/07/05 - 2021/12/31 Investigator - Project Principal Investigator - POCI-01-0145-FEDER-028160- "A2A receptors control axon formation during neuronal development: new strategies to arrest epileptogenesis" FCT- Fundação para a Ciência e a Tecnologia, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2016/06 - 2018/06 Postdoctoral fellowship FCT- Fundação para a Ciência e a Tecnologia, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2015/11 - 2016/05 Project Investigator Alzheimer's Association, Estados Unidos
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2014/05 - 2015/08 Postdoctoral fellowship Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2007/05 - 2011/12 PhD fellowship FCT- Fundação para a Ciência e a Tecnologia, Portugal
Instituto de Neurociencias de Alicante Laboratorio Synaptic Physiology, Espanha
2006/08 - 2007/05 Project Investigator Consejo Superior de Investigaciones Científicas, Espanha
Instituto de Neurociencias de Alicante CSIC-UMH, Espanha
2003 - 2006 Project Investigator Fundação para a Ciência e a Tecnologia, I.P., Portugal
Universidade de Coimbra Faculdade de Medicina, Portugal
Projetos

Bolsa

Designação Financiadores
2015 - 2017/01 P2Y1 Receptor-CRMP2 Control Synaptic Loss and Memory Impairment in Early Alzheimer’s Disease
grant.alz6e384926
Alzheimer's Association
2007 - 2011/12 Role of kainate receptors in neuronal maturation, navigation and synaptogenesis
SFRH / BD / 27517 / 2006
Bolseiro de Doutoramento
Instituto de Neurociencias de Alicante CSIC-UMH, Espanha
FCT- Fundação para a Ciência e a Tecnologia

Projeto

Designação Financiadores
2018 - 2021/07/05 A2A receptors control axon formation during neuronal development: new strategies to arrest epileptogenesis
PTDC/MED-NEU/28160/2017
Investigador responsável
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
FCT- Fundação para a Ciência e a Tecnologia
2016 - 2018/06 Hybrid ionotropic receptors: a new concept of receptor
PTDC/NEU-NMC/3567/2014
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
FCT- Fundação para a Ciência e a Tecnologia
2015 - 2017/01 P2Y1 Receptor-CRMP2 Control Synaptic Loss and Memory Impairment in Early Alzheimer’s Disease
NIRG-15-361884
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Alzheimer's Association
2013 - 2014/04 Role of P2Y1 receptors on neuronal polarity and axonal growth: implications for mossy fiber sprouting in epileptic phenomena.
126861
Provided by PTCRIS: 126861
FCT-EXPL/NEU-NMC/0671/2012
FCT-EXPL/NEU-NMC/0671/2012
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia, I.P.
Produções

Publicações

Artigo em revista
  1. Joana M Marques. "Neurogenesis and Gliogenesis: Relevance of Adenosine for Neuroregeneration in Brain Disorders". Journal of Caffeine and Adenosine Research (2019): http://dx.doi.org/10.1089/caff.2019.0010.
    10.1089/caff.2019.0010
  2. Joana M Marques. "Purinergic signalling and brain development". Seminars in Cell & Developmental Biology (2019): http://dx.doi.org/10.1016/j.semcdb.2018.12.001.
    10.1016/j.semcdb.2018.12.001
  3. Simões, A.P.; Silva, C.G.; Marques, J.M.; Pochmann, D.; Porciúncula, L.O.; Ferreira, S.; Oses, J.P.; et al. "Glutamate-induced and NMDA receptor-mediated neurodegeneration entails P2Y1 receptor activation". Cell Death and Disease 9 3 (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85042216497&partnerID=MN8TOARS.
    10.1038/s41419-018-0351-1
  4. Pinheiro, B.S.; Lemos, C.; Neutzling Kaufmann, F.; Marques, J.M.; da Silva-Santos, C.S.; Carvalho, E.; Mackie, K.; et al. "Hierarchical glucocorticoid-endocannabinoid interplay regulates the activation of the nucleus accumbens by insulin". Brain Research Bulletin 124 (2016): 222-230. http://www.scopus.com/inward/record.url?eid=2-s2.0-84971467088&partnerID=MN8TOARS.
    10.1016/j.brainresbull.2016.05.009
  5. Rodrigues, R.J.; Almeida, T.; Díaz-Hernández, M.; Marques, J.M.; Franco, R.; Solsona, C.; Miras-Portugal, M.T.; Ciruela, F.; Cunha, R.A.. "Presynaptic P2X1-3 and a3-containing nicotinic receptors assemble into functionally interacting ion channels in the rat hippocampus". Neuropharmacology 105 (2016): 241-257. http://www.scopus.com/inward/record.url?eid=2-s2.0-84961368309&partnerID=MN8TOARS.
    10.1016/j.neuropharm.2016.01.022
  6. Lemos, C.; Rial, D.; Gonçalves, F.Q.; Pires, J.; Silva, H.B.; Matheus, F.C.; da Silva, A.C.; et al. "High sucrose consumption induces memory impairment in rats associated with electrophysiological modifications but not with metabolic changes in the hippocampus". Neuroscience 315 (2016): 196-205. http://www.scopus.com/inward/record.url?eid=2-s2.0-84952911994&partnerID=MN8TOARS.
    10.1016/j.neuroscience.2015.12.018
  7. Lemos, C.; Pinheiro, B.S.; Beleza, R.O.; Marques, J.M.; Rodrigues, R.J.; Cunha, R.A.; Rial, D.; Köfalvi, A.. "Adenosine A2B receptor activation stimulates glucose uptake in the mouse forebrain". Purinergic Signalling 11 4 (2015): 561-569. http://www.scopus.com/inward/record.url?eid=2-s2.0-84947618042&partnerID=MN8TOARS.
    10.1007/s11302-015-9474-3
  8. Ferreira, S.G.; Gonc¸alves, F.Q.; Marques, J.M.; Tomé, Â.R.; Rodrigues, R.J.; Nunes-Correia, I.; Ledent, C.; et al. "Presynaptic adenosine a2A receptors dampen cannabinoid CB1 receptor-mediated inhibition of corticostriatal glutamatergic transmission". British Journal of Pharmacology 172 4 (2015): 1074-1086. http://www.scopus.com/inward/record.url?eid=2-s2.0-84921682826&partnerID=MN8TOARS.
    10.1111/bph.12970
  9. Gonçalves, F.Q.; Pires, J.; Pliassova, A.; Beleza, R.; Lemos, C.; Marques, J.M.; Rodrigues, R.J.; et al. "Adenosine A2b receptors control A1 receptor-mediated inhibition of synaptic transmission in the mouse hippocampus". European Journal of Neuroscience 41 7 (2015): 876-886. http://www.scopus.com/inward/record.url?eid=2-s2.0-84926407234&partnerID=MN8TOARS.
    10.1111/ejn.12851
  10. Lerma, J.; Marques, J.M.. "Kainate receptors in health and disease". Neuron 80 2 (2013): 292-311. http://www.scopus.com/inward/record.url?eid=2-s2.0-84885732604&partnerID=MN8TOARS.
    10.1016/j.neuron.2013.09.045
  11. Marques, J.M.; Rodrigues, R.J.; Valbuena, S.; Rozas, J.L.; Selak, S.; Marin, P.; Aller, M.I.; Lerma, J.. "CRMP2 tethers kainate receptor activity to cytoskeleton dynamics during neuronal maturation". Journal of Neuroscience 33 46 (2013): 18298-18310. http://www.scopus.com/inward/record.url?eid=2-s2.0-84887382896&partnerID=MN8TOARS.
    10.1523/JNEUROSCI.3136-13.2013
  12. Paulo, C.; Mourão, C.; Veiga, P.M.; Marques, J.M.; Rocha, G.; Alves, A.F.; Querol, A.; et al. "Retrospective analysis of clinical yeast isolates in a hospital in the centre of Portugal: Spectrum and revision of the identification procedures". Medical Mycology 47 8 (2009): 836-844. http://www.scopus.com/inward/record.url?eid=2-s2.0-73649102062&partnerID=MN8TOARS.
    10.3109/13693780802709081
  13. Marques, J.M.; Rodrigues, R.J.; De Magalhães-Sant'Ana, A.C.; Gonçalves, T.. "Saccharomyces cerevisiae Hog1 protein phosphorylation upon exposure to bacterial endotoxin". Journal of Biological Chemistry 281 34 (2006): 24687-24694. http://www.scopus.com/inward/record.url?eid=2-s2.0-33747681596&partnerID=MN8TOARS.
    10.1074/jbc.M603753200
  14. Pinto-De-Oliveira, A.; McCance, D.; De Magalhães-Sant'Ana, A.C.; Marques, J.M.; Gonçalves, T.. "Expression of HPV16 E6 oncoprotein increases resistance to several stress conditions in Saccharomyces cerevisiae". FEMS Yeast Research 5 8 (2005): 777-787. http://www.scopus.com/inward/record.url?eid=2-s2.0-17644383654&partnerID=MN8TOARS.
    10.1016/j.femsyr.2005.02.002
Poster em conferência
  1. Ferreira, Sofia; Joana M Marques; Alçada-Morais, S; Leyva-Diaz, E; Rocha, JMM; López-Bendito, G; Cunha, RA; Rodrigues, RJ. "P2 receptors control the migration of medial ganglionic eminence-derived interneurons". Trabalho apresentado em SPN2019 meeting, 2019.
    10.1259/conf-pukrc.2017.poster-abs
  2. Xu, Xinli; Alçada-Morais, S; Rocha, JMM; Ferreira, Sofia; Beleza, RO; Cunha, RA; Rodrigues, RJ; Joana M Marques. "Adenosine A2A receptor contributes to hippocampal mossy fiber sprouting during epileptogenesis". Trabalho apresentado em SPN2019 meeting, Lisbon, Portugal, 2019.
    10.1259/conf-pukrc.2017.poster-abs
  3. Alçada-Morais, S; Rocha, JMM; Moreno-Juan, V; Gonçalves, Nélio; Andreas, B; Ferreira, Sofia; Joana M Marques; et al. "Cortical Neuron migration entails A2A receptor-driven neuronal polarization and axon formation". Trabalho apresentado em SPN2019 meeting, Lisbon, Portugal, 2019.
    10.1259/conf-pukrc.2017.poster-abs
  4. Ferreira, Sofia; Joana M Marques; Alçada-Morais, S; Leyva-Diaz, E; López-Bendito, G; Cunha, RA; Rodrigues, RJ. "P2 receptors control the migration of medial ganglionic eminence-derived interneurons". Trabalho apresentado em ISN-ESN MEETING 2017, Paris, France, 2017.
    10.1259/conf-pukrc.2017.poster-abs
  5. Rodrigues, RJ; Alçada-Morais, S; Leyva-Diaz, E; Moreno-Juan, V; Gonçalves, Nélio; Andreas, B; Ferreira, Sofia; et al. "Cortical principal neurons migration entails A2A receptor-driven neuronal polarization and axon formation". Trabalho apresentado em ISN-ESN MEETING 2017, Paris, France, 2017.
    10.1259/conf-pukrc.2017.poster-abs
  6. Joana M Marques; Canas, PM; Porciúncula, LO; Queiroz, F; Xu, Xinli; Silva, CG; Fernandes, Beatriz; et al. "P2Y1 receptor is required for Aß-induced synaptic loss, plasticity deficits and memory impairment". Trabalho apresentado em ISN-ESN MEETING 2017, Paris, France, 2017.
    10.1259/conf-pukrc.2017.poster-abs
  7. Alçada-Morais, S; Xu, Xinli; Joana M Marques; Gonçalves, Nélio; Ferreira, Sofia; Beleza, RO; López-Bendito, G; Cunha, RA; Rodrigues, RJ. "Adenosine A2A receptors control axon formation during neuronal development: implications to neuronal migration and epileptogenesis". Trabalho apresentado em 7th ISN Special Conference of Neurochemistry, Coimbra, Portugal, 2016.
    10.1259/conf-pukrc.2017.poster-abs
  8. Ferreira, Sofia; Marques, JM; Alçada-Morais, S; Leyva-Diaz, E; López-Bendito, G; Cunha, RA; Rodrigues, RJ. "P2Y1 receptors control the migration of medium ganglionic eminence-derived interneurons". Trabalho apresentado em 10th FENS Forum of Neuroscience, Copenhagen, Denmark, 2016.
    10.1109/cca.2012.6402731
  9. Alçada-Morais, S; Ferreira, Sofia; Gonçalves, Nélio; Beleza, RO; Joana M Marques; Xu, Xinli; Andres, B; et al. "Adenosine A2A receptors control cortical neuronal migration". Trabalho apresentado em 10th FENS Forum of Neuroscience, Copenhagen, Denmark, 2016.
    10.1259/conf-pukrc.2017.poster-abs
  10. Pinheiro, BS; Lemos, C; Joana M Marques; Neutzling-Kaufmann, F; da Silva-Santos, CS; Rodrigues, RJ; Cunha, RA; Köfalvi, A. "Hierarchical glucocorticoid-endocannabinoid interplay regulates the metabolic state-dependent activation of the nucleus accumbens by insulin". Trabalho apresentado em XIV Portuguese Society for Neuroscience Meeting, Póvoa do Varzim, Portugal, 2015.
    10.1259/conf-pukrc.2017.poster-abs
  11. Xu, Xinli; Alçada-Morais, S; Joana M Marques; Ferreira, Sofia; Beleza, RO; Cunha, RA; Rodrigues, RJ. "Adenosine A2A receptors induce the formation of abnormal secondary axons in rat hippocampal neurons: a new target to arrest epileptogenesis". Trabalho apresentado em XIV Portuguese Society for Neuroscience Meeting, Póvoa do Varzim, Portugal, 2015.
    10.1259/conf-pukrc.2017.poster-abs
  12. Alçada-Morais, S; Ferreira, Sofia; Gonçalves, Nélio; Beleza, RO; Joana M Marques; Cunha, RA; Rodrigues, RJ. "Adenosine A2A receptors control cortical neurons migration". Trabalho apresentado em XIV Portuguese Society for Neuroscience Meeting, Póvoa do Varzim, Portugal, 2015.
    10.1259/conf-pukrc.2017.poster-abs
  13. Rodrigues, RJ; Aller, MI; Palacios, J; Joana M Marques; Cunha, RA; Lerma, J. "P2X2/GluN2B hybrid receptors: a new concept of receptor". Trabalho apresentado em XIV Portuguese Society for Neuroscience Meeting, Póvoa do Varzim, Portugal, 2015.
    10.4271/2001-24-0033
  14. Ferreira, Sofia; Joana M Marques; Alçada-Morais, S; Cunha, RA; Rodrigues, RJ. "P2Y1 receptor promotes the migration of medial ganglionic eminence-derived interneurons". Trabalho apresentado em XIV Portuguese Society for Neuroscience Meeting, Póvoa do Varzim, Portugal, 2015.
    10.1259/conf-pukrc.2017.poster-abs
  15. Joana M Marques; Rodrigues, RJ; Aller, MI; Lerma, J. "Kainate receptors induce axon formation and outgrowth in mice hippocampal neurons". Trabalho apresentado em XIV Portuguese Society for Neuroscience Meeting, Póvoa do Varzim, Portugal, 2015.
    10.1259/conf-pukrc.2017.poster-abs
  16. Simões, AP; Silva, CG; Pochmann, D.; Joana M Marques; Oses, JP; Beleza, RO; Cunha, RA; Rodrigues, RJ. "Neuronal P2Y1 receptors are required for NMDAR-induced, calpain-mediated synaptic loss and neuronal death". Trabalho apresentado em 9th FENS Forum of Neuroscience, Milan, Italy, 2014.
    10.1259/conf-pukrc.2017.poster-abs
  17. Beleza, RO; Ferreira, Sofia; Alçada-Morais, S; Joana M Marques; Cunha, RA; Rodrigues, RJ. "Purinergic signaling is essential for proper neuronal polarization". Trabalho apresentado em XIII Portuguese Society for Neuroscience Meeting, Luso, Portugal, 2013.
    10.1259/conf-pukrc.2017.poster-abs
  18. Porciúncula, LO; Silva, CG; Canas, PM; Joana M Marques; Andrade, GM; Oses, JP; Gachet, C; Cunha, RA; Rodrigues, RJ. "P2Y1 receptor is involved in Abeta-induced synaptic and memory loss". Trabalho apresentado em XIII Portuguese Society for Neuroscience Meeting, Luso, Portugal, 2013.
    10.1259/conf-pukrc.2017.poster-abs
  19. Rodrigues, RJ; Porciúncula, LO; Canas, PM; Silva, CG; Joana M Marques; Andrade, GM; Oses, JP; Gachet, C; Cunha, RA. "P2Y1 receptor is involved in Abeta-induced synaptic and memory loss". Trabalho apresentado em 43rd Annual Meeting of the Society for Neuroscience, San Diego, USA, 2013.
    10.1259/conf-pukrc.2017.poster-abs
  20. Joana M Marques; Rodrigues, RJ; Valbuena, S; Rozas, JL; Selak, S; Marin, P; Aller, MI; Lerma, J. "CRMP2 tethers kainate receptor activity to cytoskeleton dynamics during development". Trabalho apresentado em 43rd Annual Meeting of the Society for Neuroscience, San Diego, USA, 2013.
    10.1259/conf-pukrc.2017.poster-abs
  21. Joana M Marques; Rodrigues, RJ; Rozas, JL; Selak, S; Lerma, J. "Bidirectional modulation of neuronal maturation by kainate receptors". Trabalho apresentado em XII meeting of the Portuguese Neuroscience Society, Lisbon, Portugal, 2011.
    10.1259/conf-pukrc.2017.poster-abs
  22. Joana M Marques; Rodrigues, RJ; Rozas, JL; Selak, S; Lerma, J. "Bidirectional modulation of neuronal maturation by kainate receptors". Trabalho apresentado em 8th world congress of International Brain Research Organization, Florence, Italy, 2011.
    10.1259/conf-pukrc.2017.poster-abs
  23. Joana M Marques; Rodrigues, RJ; Rozas, JL; Selak, S; Lerma, J. "Bidirectional modulation of neuronal maturation by kainate receptors". Trabalho apresentado em XIV Congreso Nacional de la Sociedad Española de Neurociencias, Salamanca, Spain, 2011.
  24. Rodrigues, RJ; Joana M Marques; Aller, MI; Lerma, J. "Kainate receptors modulate axonal outgrowth and neuronal polarity through the control of CRMP2 function". Trabalho apresentado em XIV Congreso Nacional de la Sociedad Española de Neurociencias, Salamanca, Spain, 2011.
    10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a2146
  25. Joana M Marques; Rodrigues, RJ; Rozas, JL; Selak, S; Aller, MI; Lerma, J. "Bidirectional modulatory role of kainate receptors on neuronal maturation". Trabalho apresentado em 41st Annual Meeting of the Society for Neuroscience, Washington D.C., USA, 2011.
    10.1259/conf-pukrc.2017.poster-abs
  26. Rodrigues, RJ; Joana M Marques; Aller, MI; Lerma, J. "Kainate receptors modulate axonal outgrowth and neuronal polarity in mice hippocampal neurons through the control of CRMP2 function". Trabalho apresentado em 41st Annual Meeting of the Society for Neuroscience, Washington D.C., USA, 2011.
    10.1259/conf-pukrc.2017.poster-abs
  27. Paulo, C; Joana M Marques; Mourão, C; Nogueira, C; Alves, M; Meliço-Silvestre, A; Alves, AF; Quintas, C; Gonçalves, Teresa. "Understanding yeast infections epidemiology: a revision of the diagnosis/identification procedures applied to the Portuguese population". Trabalho apresentado em 3rd Trends in Medical Mycology, Turin, Italy, 2007.
    10.1259/conf-pukrc.2017.poster-abs
  28. Joana M Marques; Rodrigues, RJ; Gonçalves, Teresa. "Characterization of S. cerevisiae Hog1 protein activation upon bacterial LPS-exposure". Trabalho apresentado em XXIInd International Conference on Yeast Genetics and Molecular Biology, Bratislava, Slovaquia, 2005.
  29. Gonçalves, Teresa; Oliveira, AP; Joana M Marques; McCance, D; de Magalhães-Sant'Ana, AC; Santos, P.; Regateiro, F; Castro, IM. "Saccharomyces cerevisiae stress resistance patterns upon HPV16.E6 expression". Trabalho apresentado em 25th International Specialized Symposium on Yeasts, Oropesa del Mar, Spain, 2005.
    10.1259/conf-pukrc.2017.poster-abs
  30. Joana M Marques; Gonçalves, Teresa. "Functional Characterization of Hog1 p response upon treatment with p38 animal cell protein activators". Trabalho apresentado em 23rd International Specialised Symposium on Yeasts, Budapest, Hungary, 2003.
    10.1259/conf-pukrc.2017.poster-abs
  31. Joana M Marques; Gonçalves, Teresa. "Yeast thermal death: metabolic alterations due to an apoptotic-like process". Trabalho apresentado em III Congresso de Investigação em Medicina, Coimbra, Portugal, 2002.
    10.1259/conf-pukrc.2017.poster-abs
  32. Joana M Marques; Gonçalves, Teresa. "Yeast thermal death: metabolic alterations due to an apoptotic-like process". Trabalho apresentado em XIII Congresso Nacional de Bioquímica, Lisbon, Portugal, 2002.
    10.1259/conf-pukrc.2017.poster-abs
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2017 Neuronal migration: a critical journey for a healthy brain. XLVI Conferências de Genética Doutor Jacinto Magalhães – Neurogenética Pediátrica, Porto, Portugal
2016 Role of P2 receptors in the migration of medial ganglionic eminence-derived interneurons XLVI Meeting of the Portuguese Society for Pharmacology, Porto, Portugal
2016 Adenosine A2a receptors control cortical neurons migration XLVI Meeting of the Portuguese Society for Pharmacology, Porto, Portugal
2016 P2Y1 receptors control the migration of medium ganglionic eminence-derived interneurons Brain Without Borders meeting, Coimbra, Portugal
2016 Cortical principal neurons migration entails A2A receptor-driven neuronal polarization and axon formation XV meeting SPN 2017, Minho, Portugal
2014 Adenosine A2A receptors influence the establishment of neuronal polarity of rat hippocampal neurons XLIV Meeting of the Portuguese Society for Pharmacology, Coimbra, Portugal
2014 The bidirectional modulation of axonal outgrowth of rat hippocampal neurons by P2 receptors should involve a differential regulation of CRMP2 protein XLIV Meeting of the Portuguese Society for Pharmacology, Coimbra, Portugal
2014 P2Y1R is required for Aß-induced synaptic and memory loss most likely by contributing to the phosphorylation of CRMP2 XLIV Meeting of the Portuguese Society for Pharmacology, Coimbra, Portugal
2013 CRMP2 thethers kainate receptor activity to cytoskeleton dynamics during development XLIII annual meeting of Portuguese Society for Pharmacology, Porto, Portugal
2013 CRMP2 tethers kainate receptor activity to cytoskeleton dynamics during development XIII Portuguese Society for Neuroscience Meeting, Luso, Portugal
2013 P2Y1 receptor is involved in Abeta-induced synaptic and memory loss 27th Meeting of the Grupo de Estudos do Envelhecimento Cerebral e Demência, Coimbra, Portugal
2013 CRMP2 tethers kainate receptor activity to cytoskeleton dynamics during development
IBMC, Porto, Portugal

Orientação

Título / Tema
Papel desempenhado
Curso (Tipo)
Instituição / Organização
2019/03 - 2019/07 Role of P2Y1R in the regulation of NMDARS in an heterologous expression system.
Coorientador de Diana Filipa Ribeiro e Silva Maciel Lourenço
Biologia (Licenciatura/Bacharelato)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2019/03 - 2019/07 Optimization of 3D medial ganglionic eminence explant cultures for evaluation of interneuron migration.
Orientador de Matilde Maria Cabral Neves Afonso
Biologia (Licenciatura/Bacharelato)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2019 - 2019 Characterization of the intracelular signalling pathways mediating the effects of purinergic receptors in dendritic and axonal formation and outgrowth
Orientador de João Miguel Miranda da Rocha
Biologia Celular e Molecular (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2018/02 - 2018/07 Characterization of the Abeta-1-42-induced modification in the phosphorylation of CRMP2 in mice hippocampal neurons.
Orientador de Sara Patrícia Morais de oliveira Jorge Dias
Bioquímica (Licenciatura/Bacharelato)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2017/03 - 2018/02 Characterization of Abeta-induced P2Y1 receptor-mediated phosphylation of CRMP2
Orientador de Valentina Ruggiero
Science and Genetic Technologies (Mestrado)
Università degli Studi del Sannio, Itália
2015/03 - 2015/12 Characterization of glutamate-induced modifications in CRMP2 protein in rat hippocampal neurons
Orientador de José Alexandre Garcia Marinho da Silva
Biotecnologia (Licenciatura/Bacharelato)
Instituto Politécnico de Coimbra Escola Superior Agrária de Coimbra, Portugal

Participação em evento

Descrição da atividade
Tipo de evento
Nome do evento
Instituição / Organização
2016/04 - Atual Category C for design and coordination of projects involving animal handling and experimentation by Direcção Geral de Alimentação Veterinária, Ministério da Agricultura e Veterinária, Portugal
2019/03 - 2019/03 Brain Awareness Week promoted by the science communication office of CNC- seminar and activities in “2º Jardim-Escola João de Deus de Coimbra
2017/11 - 2017/11 Science & Technology week promoted by the science communication office of CNC- activities in “2º Jardim-Escola João de Deus de Coimbra
2017/03 - 2017/03 Brain Awareness Week promoted by the science communication office of CNC- seminar and activities in “2º Jardim-Escola João de Deus de Coimbra
2016/03 - 2016/03 Brain Awareness Week promoted by the science communication office of CNC- seminar and activities in “APPACDM de Coimbra” and in “2º Jardim-Escola João de Deus de Coimbra
2015/03 - 2015/03 Brain Awareness Week promoted by the science communication office of CNC- activities in “Forum Coimbra
2015/03 - 2015/03 Brain Awareness Week promoted by the science communication office of CNC- seminar and activities in “APPACDM de Coimbra
2014/03 - 2014/03 Brain Awareness Week promoted by the science communication office of CNC- seminar in “Escola Profissional de Ourém
2014/03 - 2014/03 Brain Awareness Week promoted by the science communication office of CNC- activities with students in “2º Jardim-Escola João de Deus de Coimbra
2013/03 - 2013/03 Brain Awareness Week promoted by the science communication office of CNC – Seminar in “Escola Secundária de Pombal
2007/12 - 2007/12 Category B for laboratory animal handling and experimentation by Conselleria d’Agricultura, Pesca I Alimentació de la Generalitat Valenciana (2007/CAE/B/0002), Spain

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2013/07/01 - 2013/07/05 Integrins, rhoGTPases and cytoskeleton, GABBA-PhD program 2013 course GABBA-PhD program 2013 (Doutoramento) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Distinções

Prémio

2014 Best Paper in Cellular and Molecular Neurobiology 2014

Outra distinção

2011 Travel Grant - IBRO
2011 Travel Grant - Portuguese Neuroscience Society
2005 Grant - International Conference on Yeast Genetics and Molecular Biology