Identificação pessoal

Nome completo

Natacha Maria Gonçalves Silva Sousa

Nomes de citação

• Gonçalves-Sousa, Natacha
• Sousa, NG

Identificadores de autor

Ciência ID

8F19-8863-6B75

ORCID iD

0000-0001-5190-1122

Idiomas

Idioma	Conversação	Leitura	Escrita	Compreensão	Peer-review
Inglês	Utilizador proficiente (C1)	Utilizador proficiente (C1)	Utilizador proficiente (C1)	Utilizador proficiente (C1)

	Grau	Classificação
2010/12/22 Concluído	Engenharia Biotecnológica (Mestrado) Universidade Lusófona de Humanidades e Tecnologias, Portugal
1999/07/31 Concluído	Biotechnology (Postgraduate Certificate) De Montfort University Leicester School of Pharmacy, Reino Unido
1998/12/23 Concluído	Engenharia Biotecnológica (Licenciatura) Universidade Lusófona de Humanidades e Tecnologias, Portugal

Ciência

	Categoria Profissional Instituição de acolhimento	Empregador
2012/01/01 - Atual	Gestão de Ciência e Tecnologia	Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
2007/04/01 - 2011/12/31	Investigador (Investigação)	Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
2005/08/01 - 2007/03/31	Investigador (Investigação)	Instituto Gulbenkian de Ciência, Portugal
2001/01/01 - 2005/07/31	Investigador (Investigação)	Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Outros

	Categoria Profissional Instituição de acolhimento	Empregador
2000/05/01 - 2000/12/31	Estágio	Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2000/03/01 - 2000/12/31	Directora de Formação	Centro de Informação e Apoio Técnico, Portugal

Projeto

	Designação	Financiadores
2021/03/01 - Atual	Next- generation CAR-DOT cells for allogeneic adoptive cancer immunotherapy HR18-00069 Project Manager	Fundación Bancaria ”la Caixa” Em curso
2015/07/01 - 2021/02/28	MicroRNA determinants of the balance between effector and regulatory T cells in vivo CoG 646701 Bolseiro de Gestão de Ciência e Tecnologia	European Research Council Concluído
2012/11/01 - 2015/06/30	Differentiation of pro-inflammatory T cell subsets in vivo StG 260352 Bolseiro de Gestão de Ciência e Tecnologia	European Research Council Concluído
2012/02/01 - 2012/10/31	Differentiation of pro-inflammatory T cell subsets in vivo StG 260352 Bolseiro de Investigação	European Research Council Concluído
2011/01/01 - 2012/01/31	Regulation of T cell differentiation and activation by CD27-CD70 receptor-ligand interactions in the thymus and in the periphery PTDC/SAU-MII/104158/2008 Bolseiro de Investigação	Fundação para a Ciência e a Tecnologia Concluído
2010/02/01 - 2010/12/31	Identificação de ligandos para receptores de linfócitos T gd: uma abordagem genómica e transcritómica PTDC/BIA-BCM/71663/2006 Bolseiro de Investigação	Fundação para a Ciência e a Tecnologia Concluído
2007/08/01 - 2010/01/31	Molecular mechanisms of tumour antigen recognition and cellular activation of gd T lymphocytes PTDC/SAU-MII/71662/2006 Bolseiro de Técnico de Investigação	Fundação para a Ciência e a Tecnologia

Publicações

Artigo em revista	Papotto, Pedro H.; Yilmaz, Bahtiyar; Pimenta, Gonçalo; Mensurado, Sofia; Cunha, Carolina; Fiala, Gina J.; Gomes da Costa, Daniel; et al. "Maternal ¿d T cells shape offspring pulmonary type 2 immunity in a microbiota-dependent manner". Cell Reports 42 2 (2023): 112074. http://dx.doi.org/10.1016/j.celrep.2023.112074. 10.1016/j.celrep.2023.112074 Mensurado, Sofia; Rei, Margarida; Lança, Telma; Ioannou, Marianna; Gonçalves-Sousa, Natacha; Kubo, Hiroshi; Malissen, Marie; et al. "Tumor-associated neutrophils suppress pro-tumoral IL-17+ ¿d T cells through induction of oxidative stress". PLOS Biology 16 5 (2018): e2004990. http://dx.doi.org/10.1371/journal.pbio.2004990. 10.1371/journal.pbio.2004990 "IL-23 drives differentiation of peripheral ¿d17 T cells from adult bone marrow-derived precursors.". EMBO reports (2017): http://europepmc.org/abstract/med/28855306. 10.15252/embr.201744200 "Primary Tumors Limit Metastasis Formation through Induction of IL15-Mediated Cross-Talk between Patrolling Monocytes and NK Cells.". Cancer immunology research (2017): http://europepmc.org/abstract/med/28811289. 10.1158/2326-6066.cir-17-0082 "TCR signal strength controls thymic differentiation of discrete proinflammatory ¿d T cell subsets.". Nature immunology (2016): http://europepmc.org/abstract/med/27043412. 10.1038/ni.3424 "Murine CD27(-) V¿6(+) ¿d T cells producing IL-17A promote ovarian cancer growth via mobilization of protumor small peritoneal macrophages.". Proceedings of the National Academy of Sciences of the United States of America (2014): http://europepmc.org/abstract/med/25114209. 10.1073/pnas.1403424111 "Protective role of the inflammatory CCR2/CCL2 chemokine pathway through recruitment of type 1 cytotoxic ¿d T lymphocytes to tumor beds.". Journal of immunology (Baltimore, Md. : 1950) (2013): http://europepmc.org/abstract/med/23686489. 10.4049/jimmunol.1300434 "Analysis of invasiveness of pneumococcal serotypes and clones circulating in Portugal before widespread use of conjugate vaccines reveals heterogeneous behavior of clones expressing the same serotype.". Journal of clinical microbiology (2011): http://europepmc.org/abstract/med/21270219. 10.1128/jcm.01763-10 "Cutting edge: adaptive versus innate receptor signals selectively control the pool sizes of murine IFN-¿- or IL-17-producing ¿d T cells upon infection.". Journal of immunology (Baltimore, Md. : 1950) (2010): http://europepmc.org/abstract/med/21037088. 10.4049/jimmunol.1002283 "Inhibition of murine gammadelta lymphocyte expansion and effector function by regulatory alphabeta T cells is cell-contact-dependent and sensitive to GITR modulation.". European journal of immunology (2010): http://europepmc.org/abstract/med/19877017. 10.1002/eji.200939715 "Identification, prevalence and population structure of non-typable Streptococcus pneumoniae in carriage samples isolated from preschoolers attending day-care centres.". Microbiology (Reading, England) (2006): http://europepmc.org/abstract/med/16436425. 10.1099/mic.0.28596-0 "Assessment of band-based similarity coefficients for automatic type and subtype classification of microbial isolates analyzed by pulsed-field gel electrophoresis.". Journal of clinical microbiology (2005): http://europepmc.org/abstract/med/16272474. 10.1128/jcm.43.11.5483-5490.2005 "Properties of novel international drug-resistant pneumococcal clones identified in day-care centers of Lisbon, Portugal.". Journal of clinical microbiology (2005): http://europepmc.org/abstract/med/16145129. 10.1128/jcm.43.9.4696-4703.2005 "Effect of the seven-valent conjugate pneumococcal vaccine on carriage and drug resistance of Streptococcus pneumoniae in healthy children attending day-care centers in Lisbon.". The Pediatric infectious disease journal (2005): http://europepmc.org/abstract/med/15750461. 10.1097/01.inf.0000154326.77617.3e "Natural history of drug-resistant clones of Streptococcus pneumoniae colonizing healthy children in Portugal.". Microbial drug resistance (Larchmont, N.Y.) (2005): http://europepmc.org/abstract/med/16359190. 10.1089/mdr.2005.11.309
Poster em conferência	"IL-23 drives differentiation of peripheral gd17 T cells from adult bone marrow-derived precursors". Trabalho apresentado em Champalimaud Research Symposium 2017, 2017. "Neutrophil-mediated inhibition of pro-tumor IL-17-producing gd T cells". Trabalho apresentado em XLIII Annual Meeting of the Portuguese Society for Immunology, 2017. "Innate signals drive peripheral induction of IL-17-producing Vg4+ gd T cells in experimental autoimmune encephalomyelitis". Trabalho apresentado em World Immune Regulation Meeting XI, 2017. "Peripheral induction of IL-17-producing Vg4+ gd T cells in experimental autoimmune encephalomyelitis". Trabalho apresentado em 2nd EMBO meeting on Innate Lymphoid Cells, 2016. "A monocyte-NK cell partnership established by the primary tumour strongly inhibits melanoma metastization to the lung". Trabalho apresentado em EORTC MELANOMA GROUP MEETING, 2016. "Peripheral induction of IL-17-producing Vg4+ gd T cells in experimental autoimmune encephalomyelitis". Trabalho apresentado em 7th International Gamma-Delta T Cell Conference, 2016. "In vivo inhibition of tumour-associated IL-17-producing gd T cells by neutrophils.". Trabalho apresentado em 7th International Gamma-Delta T-Cell Conference, 2016. "Tumour-associated neutrophils inhibit pro-tumour IL17-producing gd T cells". Trabalho apresentado em Keystone symposia: Myeloid Cells, 2016. "Targeting microRNAs for modulation of the anti-tumor human gd T cell differentiation". Trabalho apresentado em XLII Annual Meeting of the Sociedade Portuguesa de Imunologia, 2016. "In vivo inhibition of tumour-associated IL-17-producing gd T cells by neutrophils". Trabalho apresentado em XLII Annual Meeting of Sociedade Portuguesa de Imunologia, 2016. "Peripheral induction of IL-17-producing Vg4+ gd T cells in experimental autoimmune encephalomyelitis". Trabalho apresentado em XLII Annual Meeting of the Portuguese Society for Immunology, 2016. "Sometimes myeloid suppressive cells get it wrong: tumour-associated neutrophils inhibit pro-tumour IL-17-producing gd T cells". Trabalho apresentado em European Cost Action. Regulatory myeloid cells (MRC) in health and disease, 2015. "Modulation of T cell fitness in the tumour microenvironment". 2015. "Molecular regulation of ¿d T cell tumour responses.". Trabalho apresentado em Cell Symposia: Cancer and Inflammation and Immunity, 2015. "In vivo inhibition of gd T cell response by polymorphonuclear myeloid-derived suppressor cells". Trabalho apresentado em Thymus@Lisbon, 2015. "In vivo inhibition of anti-tumour gd T cell responses by polymorphonuclear Myeloid-Derived Suppressor Cells". Trabalho apresentado em XL Reunião Anual da Sociedade Portuguesa de Imunologia, 2014. "Murine CD27(-) Vg6+ T cells promote ovarian cancer growth via interleukin-17 production and mobilization of small peritoneal macrophages". Trabalho apresentado em 6th International Gamma-Delta T-Cell Conference, 2014. "An unanticipated protective role for the CCR2/CCL2 pathway through recruitment of gd tumor-infiltrating lymphocytes". Trabalho apresentado em Keystone Symposium on Cancer Immunology and Immunotherapy, 2013. "The pro-inflammatory CCL2/CCR2 pathway determines tumor infiltration by ¿d T cells". Trabalho apresentado em 5th International Gamma-Delta T-Cell conference, 2012. "Adaptive versus innate receptor signals selectively control the pool size IFN-g- or IL-17-producing gd T cells upon infections.". Trabalho apresentado em XXXVI Encontro Anual da Sociedade Portuguesa da Imunologia, 2010. "Inhibition of murine gd lymphocyte expansion and effector functions by regulatory ab T-cells through GITR-mediated cell-cell interactions". Trabalho apresentado em 4th International Gamma-Delta T-Cell conference, 2010. "Inhibition of murine gd lymphocyte expansion and effector functions by regulatory ab T-cells through GITR-mediated cell-cell interactions". Trabalho apresentado em Tri-Society Annual Conference 2009 of the Society for Leucocyte Biology, International Cytokine Society, and International Society for Interferon and Cytokine Research, 2009. "Regulation of murine ¿d Tcell activity by CD4+CD25+ gd T cells". Trabalho apresentado em XXXIV Encontro Anual da Sociedade Portuguesa da Imunologia, 2008. "Impact of the 7-valent pneumococcal conjugate vaccine in the nasopharyngeal flora of Portuguese children.". Trabalho apresentado em 5th World Congress of the World Society for Pediatric Infectious Diseases – WSPID, 2007. "Serotypes and genetic characterization of a large collection of drug-susceptible pneumococci isolated from preschool children and comparison with drug-resistant pneumococcal lineages". Trabalho apresentado em 5th International Symposium on Pneumococci and Pneumococcal Diseases, 2006. "Prevalence and diversity of serotype 16F in Streptococcus pneumoniae isolated from healthy children in Lisbon". Trabalho apresentado em MICRO´05-BIOTEC´05 – Congresso Nacional de Microbiologia e Biotecnologia, 2005. "Assessing herd immunity of the 7-valent conjugate vaccine on pneumococcal carriage of a Portuguese pediatric population". Trabalho apresentado em MICRO´05-BIOTEC´05 – Congresso Nacional de Microbiologia e Biotecnologia, 2005. "Serotypes and genetic characterization of a large collection of drug-susceptible Streptococcus pneumoniae isolated from preschool children and comparison with drug-resistant S. pneumoniae lineages.". Trabalho apresentado em MICRO´05-BIOTEC´05 – Congresso Nacional de Microbiologia e Biotecnologia, 2005. "Accurate identification of non-typeable Streptococcus pneumoniae in asymptomatic carriage.". Trabalho apresentado em MICRO´05-BIOTEC´05 – Congresso Nacional de Microbiologia e Biotecnologia, 2005. "Serotype 11A prevalence and clonal diversity in Streptococcus pneumoniae isolated from children attending day-care centers in Lisbon, Portugal". Trabalho apresentado em 15th European Congress of Clinical Microbiology and Infectious Diseases, 2005. "Effect of the 7-valent conjugate pneumococcal vaccine on the serotype distribution of drug-susceptible (DS) and drug-resistant (DR) Streptococcus pneumoniae (Pn) colonizing healthy children attending Day-Care Centers (DCCs) in Lisbon". Trabalho apresentado em 15th European Congress of Clinical Microbiology and Infectious Diseases, 2005. "Prevalence of non-typeable Streptococcus pneumoniae in carriage and insights into its population structure". Trabalho apresentado em 15th European Congress of Clinical Microbiology and Infectious Diseases, 2005. "The majority of drug-resistant pneumococci isolated from children attending day-care centers in two cities of Portugal are representatives of several internationally disseminated clones.". Trabalho apresentado em 4th International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD-4), 2004. "Risk factors for Streptococcus pneumoniae carriage in healthy children attending day-care centers (DCCs) in Lisbon and Oeiras, Portugal". Trabalho apresentado em 4th International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD-4), 2004. "The effect of the 7-valent conjugate pneumococcal vaccine Prevnar on the carriage and drug resistance of S. pneumoniae in healthy children attending Day-Care Centers (DCCs) in Lisbon: decrease in vaccine serotypes but no change in the frequency of carriage of drug resistant strains.". Trabalho apresentado em the 4th International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD-4), 2004. "Inventory of drug resistant clones of Streptococcus pneumoniae colonizing healthy children in Portugal". Trabalho apresentado em 4th International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD-4), 2004. "Properties of novel international drug-resistant pneumococcal clones identified in day-care centers (DCCs) of Lisbon, Portugal.". Trabalho apresentado em 4th International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD), 2004. "Risk factors for Streptococcus pneumoniae carriage in healthy children attending day care centers in Lisbon and Oeiras, Portugal". Trabalho apresentado em Micro'03- Congresso Nacional de Microbiologia 2003, 2003. "Fluctuation of Streptococcus pneumoniae major clones colonizing healthy children". Trabalho apresentado em Micro'03- Congresso Nacional de Microbiologia 2003, 2003. "Multiloccus Sequence Typing (MLST) of Streptococcus pneumoniae representative strains of clones colonizing children attending day care centers". Trabalho apresentado em Micro'03- Congresso Nacional de Microbiologia 2003, 2003. "Genomic Backgrounds of Drug-Resistant Pneumococci Colonizing Children Attending Day Care Centers in Portugal". Trabalho apresentado em 43rd Interscience Congress on Antimicrobials Agents and Chemotherapy (ICAAC), 2003. "Clonality of drug resistant Streptococcus pneumoniae colonizing healthy children in day care centers, in Lisbon and Oeiras, Portugal". Trabalho apresentado em International Conference of NATO and IMAB, 2003.
Tese / Dissertação	"Controlo da actividade dos linfócitos T gd por células reguladoras CD4+ CD25+ FOXP3+". Mestrado, Universidade Lusófona de Humanidades e Tecnologias, 2010. "Produção de Manganese Peroxidase pelo fungo Phanerocaete magnolia". Licenciatura, Universidade Lusófona de Humanidades e Tecnologias, 1998.

Prémio

2008	Prémio Arala Chaves Sociedade Portuguesa de Imunologia, Portugal