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Identification

Personal identification

Full name
Natacha Maria Gonçalves Silva Sousa

Citation names

  • Gonçalves-Sousa, Natacha
  • Sousa, NG

Author identifiers

Ciência ID
8F19-8863-6B75
ORCID iD
0000-0001-5190-1122

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Education
Degree Classification
2010/12/22
Concluded
 Engenharia Biotecnológica (Mestrado)
Universidade Lusófona de Humanidades e Tecnologias, Portugal
1999/07/31
Concluded
 Biotechnology (Postgraduate Certificate)
De Montfort University Leicester School of Pharmacy, United Kingdom
1998/12/23
Concluded
 Engenharia Biotecnológica (Licenciatura)
Universidade Lusófona de Humanidades e Tecnologias, Portugal
Affiliation

Science

Category
Host institution 		Employer
2012/01/01 - Current Science and Technology Management Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
2007/04/01 - 2011/12/31 Researcher (Research) Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
2005/08/01 - 2007/03/31 Researcher (Research) Instituto Gulbenkian de Ciência, Portugal
2001/01/01 - 2005/07/31 Researcher (Research) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Others

Category
Host institution 		Employer
2000/05/01 - 2000/12/31 Estágio Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2000/03/01 - 2000/12/31 Directora de Formação Centro de Informação e Apoio Técnico, Portugal
Projects

Contract

Designation Funders
2021/03/01 - Current Next- generation CAR-DOT cells for allogeneic adoptive cancer immunotherapy
HR18-00069
Project Manager
Fundación Bancaria ”la Caixa”
Ongoing
2015/07/01 - 2021/02/28 MicroRNA determinants of the balance between effector and regulatory T cells in vivo
CoG 646701
Science and Technology Management Fellow
European Research Council
Concluded
2012/11/01 - 2015/06/30 Differentiation of pro-inflammatory T cell subsets in vivo
StG 260352
Science and Technology Management Fellow
European Research Council
Concluded
2012/02/01 - 2012/10/31 Differentiation of pro-inflammatory T cell subsets in vivo
StG 260352
Research Fellow
European Research Council
Concluded
2011/01/01 - 2012/01/31 Regulation of T cell differentiation and activation by CD27-CD70 receptor-ligand interactions in the thymus and in the periphery
PTDC/SAU-MII/104158/2008
Research Fellow
Fundação para a Ciência e a Tecnologia
Concluded
2010/02/01 - 2010/12/31 Identificação de ligandos para receptores de linfócitos T gd: uma abordagem genómica e transcritómica
PTDC/BIA-BCM/71663/2006
Research Fellow
Fundação para a Ciência e a Tecnologia
Concluded
2007/08/01 - 2010/01/31 Molecular mechanisms of tumour antigen recognition and cellular activation of gd T lymphocytes
PTDC/SAU-MII/71662/2006
Research Technician Fellow
Fundação para a Ciência e a Tecnologia
Outputs

Publications

Conference poster
  1. "IL-23 drives differentiation of peripheral gd17 T cells from adult bone marrow-derived precursors". Paper presented in Champalimaud Research Symposium 2017, 2017.
  2. "Neutrophil-mediated inhibition of pro-tumor IL-17-producing gd T cells". Paper presented in XLIII Annual Meeting of the Portuguese Society for Immunology, 2017.
  3. "Innate signals drive peripheral induction of IL-17-producing Vg4+ gd T cells in experimental autoimmune encephalomyelitis". Paper presented in World Immune Regulation Meeting XI, 2017.
  4. "Peripheral induction of IL-17-producing Vg4+ gd T cells in experimental autoimmune encephalomyelitis". Paper presented in 2nd EMBO meeting on Innate Lymphoid Cells, 2016.
  5. "A monocyte-NK cell partnership established by the primary tumour strongly inhibits melanoma metastization to the lung". Paper presented in EORTC MELANOMA GROUP MEETING, 2016.
  6. "Peripheral induction of IL-17-producing Vg4+ gd T cells in experimental autoimmune encephalomyelitis". Paper presented in 7th International Gamma-Delta T Cell Conference, 2016.
  7. "In vivo inhibition of tumour-associated IL-17-producing gd T cells by neutrophils.". Paper presented in 7th International Gamma-Delta T-Cell Conference, 2016.
  8. "Tumour-associated neutrophils inhibit pro-tumour IL17-producing gd T cells". Paper presented in Keystone symposia: Myeloid Cells, 2016.
  9. "Targeting microRNAs for modulation of the anti-tumor human gd T cell differentiation". Paper presented in XLII Annual Meeting of the Sociedade Portuguesa de Imunologia, 2016.
  10. "In vivo inhibition of tumour-associated IL-17-producing gd T cells by neutrophils". Paper presented in XLII Annual Meeting of Sociedade Portuguesa de Imunologia, 2016.
  11. "Peripheral induction of IL-17-producing Vg4+ gd T cells in experimental autoimmune encephalomyelitis". Paper presented in XLII Annual Meeting of the Portuguese Society for Immunology, 2016.
  12. "Sometimes myeloid suppressive cells get it wrong: tumour-associated neutrophils inhibit pro-tumour IL-17-producing gd T cells". Paper presented in European Cost Action. Regulatory myeloid cells (MRC) in health and disease, 2015.
  13. "Modulation of T cell fitness in the tumour microenvironment". 2015.
  14. "Molecular regulation of ¿d T cell tumour responses.". Paper presented in Cell Symposia: Cancer and Inflammation and Immunity, 2015.
  15. "In vivo inhibition of gd T cell response by polymorphonuclear myeloid-derived suppressor cells". Paper presented in Thymus@Lisbon, 2015.
  16. "In vivo inhibition of anti-tumour gd T cell responses by polymorphonuclear Myeloid-Derived Suppressor Cells". Paper presented in XL Reunião Anual da Sociedade Portuguesa de Imunologia, 2014.
  17. "Murine CD27(-) Vg6+ T cells promote ovarian cancer growth via interleukin-17 production and mobilization of small peritoneal macrophages". Paper presented in 6th International Gamma-Delta T-Cell Conference, 2014.
  18. "An unanticipated protective role for the CCR2/CCL2 pathway through recruitment of gd tumor-infiltrating lymphocytes". Paper presented in Keystone Symposium on Cancer Immunology and Immunotherapy, 2013.
  19. "The pro-inflammatory CCL2/CCR2 pathway determines tumor infiltration by ¿d T cells". Paper presented in 5th International Gamma-Delta T-Cell conference, 2012.
  20. "Adaptive versus innate receptor signals selectively control the pool size IFN-g- or IL-17-producing gd T cells upon infections.". Paper presented in XXXVI Encontro Anual da Sociedade Portuguesa da Imunologia, 2010.
  21. "Inhibition of murine gd lymphocyte expansion and effector functions by regulatory ab T-cells through GITR-mediated cell-cell interactions". Paper presented in 4th International Gamma-Delta T-Cell conference, 2010.
  22. "Inhibition of murine gd lymphocyte expansion and effector functions by regulatory ab T-cells through GITR-mediated cell-cell interactions". Paper presented in Tri-Society Annual Conference 2009 of the Society for Leucocyte Biology, International Cytokine Society, and International Society for Interferon and Cytokine Research, 2009.
  23. "Regulation of murine ¿d Tcell activity by CD4+CD25+ gd T cells". Paper presented in XXXIV Encontro Anual da Sociedade Portuguesa da Imunologia, 2008.
  24. "Impact of the 7-valent pneumococcal conjugate vaccine in the nasopharyngeal flora of Portuguese children.". Paper presented in 5th World Congress of the World Society for Pediatric Infectious Diseases – WSPID, 2007.
  25. "Serotypes and genetic characterization of a large collection of drug-susceptible pneumococci isolated from preschool children and comparison with drug-resistant pneumococcal lineages". Paper presented in 5th International Symposium on Pneumococci and Pneumococcal Diseases, 2006.
  26. "Prevalence and diversity of serotype 16F in Streptococcus pneumoniae isolated from healthy children in Lisbon". Paper presented in MICRO´05-BIOTEC´05 – Congresso Nacional de Microbiologia e Biotecnologia, 2005.
  27. "Assessing herd immunity of the 7-valent conjugate vaccine on pneumococcal carriage of a Portuguese pediatric population". Paper presented in MICRO´05-BIOTEC´05 – Congresso Nacional de Microbiologia e Biotecnologia, 2005.
  28. "Serotypes and genetic characterization of a large collection of drug-susceptible Streptococcus pneumoniae isolated from preschool children and comparison with drug-resistant S. pneumoniae lineages.". Paper presented in MICRO´05-BIOTEC´05 – Congresso Nacional de Microbiologia e Biotecnologia, 2005.
  29. "Accurate identification of non-typeable Streptococcus pneumoniae in asymptomatic carriage.". Paper presented in MICRO´05-BIOTEC´05 – Congresso Nacional de Microbiologia e Biotecnologia, 2005.
  30. "Serotype 11A prevalence and clonal diversity in Streptococcus pneumoniae isolated from children attending day-care centers in Lisbon, Portugal". Paper presented in 15th European Congress of Clinical Microbiology and Infectious Diseases, 2005.
  31. "Effect of the 7-valent conjugate pneumococcal vaccine on the serotype distribution of drug-susceptible (DS) and drug-resistant (DR) Streptococcus pneumoniae (Pn) colonizing healthy children attending Day-Care Centers (DCCs) in Lisbon". Paper presented in 15th European Congress of Clinical Microbiology and Infectious Diseases, 2005.
  32. "Prevalence of non-typeable Streptococcus pneumoniae in carriage and insights into its population structure". Paper presented in 15th European Congress of Clinical Microbiology and Infectious Diseases, 2005.
  33. "The majority of drug-resistant pneumococci isolated from children attending day-care centers in two cities of Portugal are representatives of several internationally disseminated clones.". Paper presented in 4th International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD-4), 2004.
  34. "Risk factors for Streptococcus pneumoniae carriage in healthy children attending day-care centers (DCCs) in Lisbon and Oeiras, Portugal". Paper presented in 4th International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD-4), 2004.
  35. "The effect of the 7-valent conjugate pneumococcal vaccine Prevnar on the carriage and drug resistance of S. pneumoniae in healthy children attending Day-Care Centers (DCCs) in Lisbon: decrease in vaccine serotypes but no change in the frequency of carriage of drug resistant strains.". Paper presented in the 4th International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD-4), 2004.
  36. "Inventory of drug resistant clones of Streptococcus pneumoniae colonizing healthy children in Portugal". Paper presented in 4th International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD-4), 2004.
  37. "Properties of novel international drug-resistant pneumococcal clones identified in day-care centers (DCCs) of Lisbon, Portugal.". Paper presented in 4th International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD), 2004.
  38. "Risk factors for Streptococcus pneumoniae carriage in healthy children attending day care centers in Lisbon and Oeiras, Portugal". Paper presented in Micro'03- Congresso Nacional de Microbiologia 2003, 2003.
  39. "Fluctuation of Streptococcus pneumoniae major clones colonizing healthy children". Paper presented in Micro'03- Congresso Nacional de Microbiologia 2003, 2003.
  40. "Multiloccus Sequence Typing (MLST) of Streptococcus pneumoniae representative strains of clones colonizing children attending day care centers". Paper presented in Micro'03- Congresso Nacional de Microbiologia 2003, 2003.
  41. "Genomic Backgrounds of Drug-Resistant Pneumococci Colonizing Children Attending Day Care Centers in Portugal". Paper presented in 43rd Interscience Congress on Antimicrobials Agents and Chemotherapy (ICAAC), 2003.
  42. "Clonality of drug resistant Streptococcus pneumoniae colonizing healthy children in day care centers, in Lisbon and Oeiras, Portugal". Paper presented in International Conference of NATO and IMAB, 2003.
Journal article
  1. Papotto, Pedro H.; Yilmaz, Bahtiyar; Pimenta, Gonçalo; Mensurado, Sofia; Cunha, Carolina; Fiala, Gina J.; Gomes da Costa, Daniel; et al. "Maternal ¿d T cells shape offspring pulmonary type 2 immunity in a microbiota-dependent manner". Cell Reports 42 2 (2023): 112074. http://dx.doi.org/10.1016/j.celrep.2023.112074.
    10.1016/j.celrep.2023.112074
  2. Mensurado, Sofia; Rei, Margarida; Lança, Telma; Ioannou, Marianna; Gonçalves-Sousa, Natacha; Kubo, Hiroshi; Malissen, Marie; et al. "Tumor-associated neutrophils suppress pro-tumoral IL-17+ ¿d T cells through induction of oxidative stress". PLOS Biology 16 5 (2018): e2004990. http://dx.doi.org/10.1371/journal.pbio.2004990.
    10.1371/journal.pbio.2004990
  3. "IL-23 drives differentiation of peripheral ¿d17 T cells from adult bone marrow-derived precursors.". EMBO reports (2017): http://europepmc.org/abstract/med/28855306.
    10.15252/embr.201744200
  4. "Primary Tumors Limit Metastasis Formation through Induction of IL15-Mediated Cross-Talk between Patrolling Monocytes and NK Cells.". Cancer immunology research (2017): http://europepmc.org/abstract/med/28811289.
    10.1158/2326-6066.cir-17-0082
  5. "TCR signal strength controls thymic differentiation of discrete proinflammatory ¿d T cell subsets.". Nature immunology (2016): http://europepmc.org/abstract/med/27043412.
    10.1038/ni.3424
  6. "Murine CD27(-) V¿6(+) ¿d T cells producing IL-17A promote ovarian cancer growth via mobilization of protumor small peritoneal macrophages.". Proceedings of the National Academy of Sciences of the United States of America (2014): http://europepmc.org/abstract/med/25114209.
    10.1073/pnas.1403424111
  7. "Protective role of the inflammatory CCR2/CCL2 chemokine pathway through recruitment of type 1 cytotoxic ¿d T lymphocytes to tumor beds.". Journal of immunology (Baltimore, Md. : 1950) (2013): http://europepmc.org/abstract/med/23686489.
    10.4049/jimmunol.1300434
  8. "Analysis of invasiveness of pneumococcal serotypes and clones circulating in Portugal before widespread use of conjugate vaccines reveals heterogeneous behavior of clones expressing the same serotype.". Journal of clinical microbiology (2011): http://europepmc.org/abstract/med/21270219.
    10.1128/jcm.01763-10
  9. "Cutting edge: adaptive versus innate receptor signals selectively control the pool sizes of murine IFN-¿- or IL-17-producing ¿d T cells upon infection.". Journal of immunology (Baltimore, Md. : 1950) (2010): http://europepmc.org/abstract/med/21037088.
    10.4049/jimmunol.1002283
  10. "Inhibition of murine gammadelta lymphocyte expansion and effector function by regulatory alphabeta T cells is cell-contact-dependent and sensitive to GITR modulation.". European journal of immunology (2010): http://europepmc.org/abstract/med/19877017.
    10.1002/eji.200939715
  11. "Identification, prevalence and population structure of non-typable Streptococcus pneumoniae in carriage samples isolated from preschoolers attending day-care centres.". Microbiology (Reading, England) (2006): http://europepmc.org/abstract/med/16436425.
    10.1099/mic.0.28596-0
  12. "Assessment of band-based similarity coefficients for automatic type and subtype classification of microbial isolates analyzed by pulsed-field gel electrophoresis.". Journal of clinical microbiology (2005): http://europepmc.org/abstract/med/16272474.
    10.1128/jcm.43.11.5483-5490.2005
  13. "Properties of novel international drug-resistant pneumococcal clones identified in day-care centers of Lisbon, Portugal.". Journal of clinical microbiology (2005): http://europepmc.org/abstract/med/16145129.
    10.1128/jcm.43.9.4696-4703.2005
  14. "Effect of the seven-valent conjugate pneumococcal vaccine on carriage and drug resistance of Streptococcus pneumoniae in healthy children attending day-care centers in Lisbon.". The Pediatric infectious disease journal (2005): http://europepmc.org/abstract/med/15750461.
    10.1097/01.inf.0000154326.77617.3e
  15. "Natural history of drug-resistant clones of Streptococcus pneumoniae colonizing healthy children in Portugal.". Microbial drug resistance (Larchmont, N.Y.) (2005): http://europepmc.org/abstract/med/16359190.
    10.1089/mdr.2005.11.309
Thesis / Dissertation
  1. "Controlo da actividade dos linfócitos T gd por células reguladoras CD4+ CD25+ FOXP3+". Master, Universidade Lusófona de Humanidades e Tecnologias, 2010.
  2. "Produção de Manganese Peroxidase pelo fungo Phanerocaete magnolia". Degree, Universidade Lusófona de Humanidades e Tecnologias, 1998.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2015/09 Modulation of T cell fitness in the tumour microenvironment iMed Conference 7.0
(Lisboa, Portugal)
2015/07/02 In vivo inhibition of gd T cell response by polymorphonuclear myeloid-derived suppressor cells 1st Symposium on Immunomodulation in Cancer & Regeneration
(Porto, Portugal)

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2023/10/01 - Current Organização local da XLIX Reunião Anual da Sociedade Portuguesa de Imunologia & 5th SICR-Symposium on Immunomodulation in Cancer and Regeneration - Modulating Inflammation (2024/04/16 - 2024/04/19)
Congress (Co-organisor)
 Sociedade Portuguesa de Imunologia, Portugal

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2022/11/01 - 2023/12/31 10th International ¿d T cell conference (2023/06/20 - 2023/06/23)
Congress (Co-organisor)
 Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal

Sociedade Portuguesa de Imunologia, Portugal
2022/10/01 - 2023/08/01 Organização local da XLVIII Reunião Anual da Sociedade Portuguesa de Imunologia (2023/03/29 - 2023/03/31)
Congress (Co-organisor)
 Sociedade Portuguesa de Imunologia, Portugal

Universidade de Aveiro, Portugal
2021/10/01 - 2022/06/30 Organização local da XLVII Reunião Anual da Sociedade Portuguesa de Imunologia (2022/04/20 - 2022/04/22)
Congress (Co-organisor)
 Sociedade Portuguesa de Imunologia, Portugal

Universidade Nova de Lisboa, Portugal
2020/10 - 2021/10 Organização local da XLVI Reunião Anual da Sociedade Portuguesa de Imunologia (2021/05/20 - 2021/05/21)
Congress (Co-organisor)
 Sociedade Portuguesa de Imunologia, Portugal

Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2018/10 - 2019/06 Organização local da XLV Reunião Anual da Sociedade Portuguesa de Imunologia (2019/05/15 - 2019/05/17)
Congress (Co-organisor)
2017/10 - 2018/09 Organização local da XLIV Reunião Anual da Sociedade Portuguesa de Imunologia (2017/06/27 - 2017/06/29)
Congress (Co-organisor)
2016/10 - 2017/09 Organização local de XLIII Reunião Anual da Sociedade Portuguesa de Imunologia (2017/06/14 - 2017/06/16)
Congress (Co-organisor)
 Sociedade Portuguesa de Imunologia, Portugal
2015/10 - 2016/07 Organização local da XLII Reunião Anual da Sociedade Portuguesa de Imunologia (2016/06/01 - 2016/06/03)
Congress (Co-organisor)
2014/11 - 2015/07 Organização local de Thymus@Lisbon (2015/06/12 - 2015/06/12)
Symposium (Co-organisor)
 Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
2013/11 - 2014/11 Organização local da XL Reunião Anual da Sociedade Portuguesa de Imunologia (2014/10/13 - 2014/10/15)
Congress (Co-organisor)
 Sociedade Portuguesa de Imunologia, Portugal
2011/06 - 2011/12 Organização local de New Frontiers in Biological Therapy (2011/11/26 - 2011/11/26)
Symposium (Co-organisor)
 Sociedade Portuguesa de Imunologia, Portugal
2010/08 - 2011/04 Organização local de International School of Immunology 2011 (2011/03/28 - 2011/04/01)
Other (Co-organisor)
 Sociedade Portuguesa de Imunologia, Portugal
2009/03 - 2009/10 Organização local da XXXV Reunião Anual da Sociedade Portuguesa de Imunologia (2009/09/28 - 2009/09/30)
Congress (Co-organisor)
 Sociedade Portuguesa de Imunologia, Portugal
Distinctions

Award

2008 Prémio Arala Chaves
Sociedade Portuguesa de Imunologia, Portugal