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Rui Miguel Oliveira da Costa (RC) graduated in Biology in 2006 and obtained a PhD in Cell Biology on 2011/12/06 from the Faculty of Science and Technology of the University of Coimbra, with highest honors. He is currently an Invited Auxiliary Researcher at the Center for Neurosciences and Cell Biology (CNC/CIBB), University of Coimbra, starting his own subgroup RARE Biology. Over the last years, RC has demonstrated a strong and sustained scientific productivity. He has published a total of 22 PEER-REVIEWED ARTICLES in international journals (8 AS FIRST OR SENIOR AUTHOR), 2 BOOK CHAPTERS, and is author of 2 PREPRINTS currently under peer review, several of which appeared in top percentile journals (1–10%) in the fields of Cell Biology, Neuroscience, and Aging (e.g. BRAIN, CELL REPORTS, AGING CELL, WIREs RNA, NEUROBIOLOGY OF AGING). Of these publications, 8 have been published in the PAST 6 YEARS. Adding to this record, Rui has contributed to 13 publications in scientific meeting supplements and conference proceedings. His work has accumulated over 1700 citations, with a significant proportion since 2021, and he holds an h-index of 18 (Google Scholar). His main scientific contributions lie in Medical and Health Sciences, with emphasis on Neurosciences and Basic Medicine, as well as in Biological Sciences, particularly Cell and Synapse Biology, Axonal Development and Degeneration, Aging, and neurodevelopmental Disorders. RC has participated in numerous competitive research projects, acting as PRINCIPAL INVESTIGATOR IN 3 PROJECTS (including in the LAST FCT CALL - PROJECT THAT WILL SUPPORT THE WORKOF THIS APPLICATION COMPETE2030-FEDER-00676600, FCT – “Understanding RNA-Binding Protein hnRNPH2 Mutations: Implications for Synaptic Function and Neurodevelopmental Disorders”), as PhD Fellow in 1 project, Postdoctoral Fellow in 1 project, Research Technician Fellow in 1 project, and Researcher in 11 projects. His professional activities resulted in extensive national and international collaborations, with co-authorship involving more than 240 collaborators. He acquired broad INTERNATIONAL SCIENTIFIC EXPERTISE through work in five laboratories in Portugal, the USA, and Italy, including advanced training in renowned laboratories in Alzheimer’s disease and axonal biology (notably Klein’s Lab at Northwestern University – USA and the Cancedda’s lab at IIT - ITALY). He masters a wide range of methodologies, including advanced microscopy, molecular biology, neuronal cultures, cell lines, in vivo models, in utero electroporation, MCAo, and human sample processing. He also completed FELASA Category C training in Laboratory Animal Science. RC has been actively involved in academic teaching, supervision, and scientific dissemination. He has lectured in BSc, MSc, and PhD programs at the Universities of Coimbra and Algarve (>320 hours); supervised 1 PhD student, formally supervised 8 MSc dissertations and co-supervised 5, and mentored more than 13 MSc and PhD students during laboratory internships. He has served as main opponent in several MSc thesis defenses (13). He ORGANIZED 7 SCIENTIFIC EVENTS, participated in over 35 national and international meetings, and has been involved in outreach and science communication activities. His scientific excellence has been recognized with 12 AWARDS AND HONORS, including a scientific incentive grant (2022), highly competitive PhD and Postdoctoral fellowships from FCT, as well as a best oral presentation award at a national meeting (2024). RC is an ad hoc reviewer for several international scientific journals, including Aging Cell. His research keywords reflect a multidisciplinary focus on Neurodevelopment disorders, Alzheimer’s disease, ER stress, mitochondria, synaptic and axonal biology, aging and metabolism, biotechnology, advanced therapies, and molecular mechanisms of brain diseases. RC benefited from two paternity leaves (2017 and 2023).
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Identificação

Identificação pessoal

Nome completo
Rui Miguel Oliveira da Costa
Data de nascimento
1983/06/17
Género
Masculino

Nomes de citação

  • Costa RO
  • Rui O Costa
  • Costa, Rui

Identificadores de autor

Ciência ID
8D18-658D-0961
ORCID iD
0000-0002-2652-7500
Google Scholar ID
gJoLzOwAAAAJ
Researcher Id
K-6898-2013
Scopus Author Id
36486010000

Endereços de correio eletrónico

  • ruiocosta@gmail.com (Profissional)
  • rui.costa@cnc.uc.pt (Profissional)

Telefones

Telefone
  • (+351) 239820190 (Profissional)
  • (+351) 304502914 (Profissional)
Telemóvel
  • (+351) 965138876 (Pessoal)

Moradas

  • Centro de NeuroCiências e Biologia Celular. Rua Larga, Faculdade de Medicina, Polo I, 2ºpiso, Lab 206a, Universidade de Coimbra, 3004-504, Coimbra, Coimbra, Portugal (Profissional)
  • Rua Do Brasil Nº351 2ºDir, 3030-175, Coimbra, Coimbra, Portugal (Pessoal)

Websites

Domínios de atuação

  • Ciências Médicas e da Saúde - Biotecnologia Médica
  • Ciências Naturais - Ciências Biológicas - Biologia Celular
  • Ciências Médicas e da Saúde - Medicina Básica - Neurociências

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português (Idioma materno)
Inglês Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Italiano Utilizador independente (B2) Utilizador independente (B2) Utilizador elementar (A2) Utilizador proficiente (C1) Utilizador independente (B2)
Francês Utilizador independente (B1) Utilizador independente (B2) Utilizador elementar (A2) Utilizador independente (B2) Utilizador elementar (A2)
Japonês Utilizador elementar (A2) Utilizador elementar (A2) Utilizador elementar (A2) Utilizador elementar (A2) Utilizador elementar (A2)
Espanhol; Castelhano Utilizador elementar (A1) Utilizador independente (B2) Utilizador elementar (A1) Utilizador independente (B2) Utilizador elementar (A2)
Formação
Grau Classificação
2016/06/17 - 2016/06/24
Concluído
 Workshop de Aceleração de Ideias de Negócio “Ideation Week Experience 2016” (Outros)
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2006/10/01 - 2011/12/06
Concluído
 Doutoramento em Biologia - especialidade em Biologia Celular (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Endoplasmic reticulum stress during amyloid ß peptide-induced cell death: role of mitochondria and glutamatergic N-methyl-D-aspartate receptors" (TESE/DISSERTAÇÃO)
 Aprovado com Distinção e Louvor, por Unanimidade.
2010/04/19 - 2010/04/30
Concluído
 Course on Laboratorial Animal Science (LAS) course - FELASA cat C (Pós-Graduação)
CNC.IBILI, Portugal
 Approved
2001/09 - 2006/07/05
Concluído
 Biologia (Licenciatura)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Role of mitochondria in the endoplasmic reticulum-mediated apoptosis induced by the amyloid-beta peptide " (TESE/DISSERTAÇÃO)
 15/20 (15.4 valores)
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2025/05 - Atual Investigador Auxiliar Convidado (carreira) (Investigação) Center for Neurosciences and Cell Biology, University of Coimbra, Portugal
Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
2019/02/05 - 2025/01 Investigador Contratado (Investigação) Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
2013/01/01 - 2019/02/04 Pós-doutorado (Investigação) CNC.IBILI, Portugal
CNC.IBILI, Portugal
2015/09 - 2016/01 Investigador visitante (Investigação) Istituto Italiano di Tecnologia, Itália
Istituto Italiano di Tecnologia, Itália
2006/10/01 - 2011/12/06 Investigador (Investigação) CNC.IBILI, Portugal
CNC.IBILI, Portugal
2008/06 - 2009/03 Investigador visitante (Investigação) Northwestern University - Chicago, Estados Unidos
Northwestern University - Chicago, Estados Unidos

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2011/01 - 2011/09 Research Technician CNC.IBILI, Portugal
Projetos

Bolsa

Designação Financiadores
2021/07/01 - Atual Uncovering the molecular machinery responsible for cargo sorting in neuronal polarization
PTDC/BIA-CEL/2286/2020
Investigador
Fundação para a Ciência e a Tecnologia
2019/02/05 - Atual BaiTS - Biodegradable dendrimers for Targeted neuroprotective therapies in Stroke.
PTDC/CTM-NAN/3547/2014.
Investigador
2019 - Atual Strategic Plan CNC.IBILI
UID/ NEU/04539/2019
Investigador
Center for Neurosciences and Cell Biology, University of Coimbra, Portugal
 Fundação para a Ciência e a Tecnologia
2025/10 - 2028/09 Understanding RNA-Binding Protein hnRNPH2 Mutations: Implications for Synaptic Function and Neurodevelopmental Disorders.
COMPETE2030-FEDER-00676600
Investigador responsável
Fundação para a Ciência e a Tecnologia
2022 - 2023 The RNA-binding protein hnRNPH2: a novel player in epileptogenesis
n.a
Investigador responsável
Center for Neurosciences and Cell Biology, University of Coimbra, Portugal
 Liga Portuguesa Contra a Epilepsia
Em curso
2013/01/01 - 2019/02 Pos-Doc project: Mechanisms underlying ribosomal regulation in axonal development
SFRH/BPD/84593/2012
Bolseiro de Pós-Doutoramento
CNC.IBILI, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2013/07 - 2014/12 Mechanism underlying ribosomal regulation in axonal development
grant.Provided by PTCRIS: 126236
EXPL/NEU-NMC/0541/2012
Investigador responsável
Center for Neurosciences and Cell Biology, University of Coimbra, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2010/06/01 - 2013/06/30 Perfis dinâmicos do óxido nítrico no cérebro: regulação da respiração celular com implicações para a doença de Alzheimer e para o envelhecimento
PTDC/SAU-NEU/103538/2008
Investigador
Universidade de Coimbra, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2010/06 - 2013/06 In vivo dynamics of nitric oxide in the brain: regulation of cellular respiration and implications for Alzheimer´s disease and aging
grant.Provided by PTCRIS: 103538
Investigador
Center for Neurosciences and Cell Biology, University of Coimbra, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2011/01/01 - 2011/09/30 The role of mRNA translation in the formation of the neuromuscular junction.
PTDC/SAU-NEU/104100/2008
Bolseiro de Técnico de Investigação
Center for Neurosciences and Cell Biology, University of Coimbra, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2009/03 - 2011/02 Phosphorylation and oxidation of NMDA receptor subunits in Alzheimer’s disease and protective role of memantine
n/a
Investigador
Lundbeck foundation (portuguese office)
2008 - 2010 Early Diagnosis of Alzheimer’s Disease: evaluation of recent classification criteria and proposal of new diagnostic tools
PIC/IC/83206/2007
Investigador
Fundação para a Ciência e a Tecnologia
2008 - 2010 Contribution of N-methyl-D-aspartate receptor subunits to neuronal dysfunction in Alzheimer’s disease
PTDC/SAU-NEU/71675/2006
Investigador
Fundação para a Ciência e a Tecnologia
2006 - 2010 PhD project: Endoplasmic reticulum stress during amyloid ß peptide-induced cell death: role of mitochondria and glutamatergic N-methyl-D-aspartate receptors
SFRH/BD/28403/2006
Bolseiro de Doutoramento
CNC.IBILI, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2005 - 2006 Cross-talk between mitochondria and endoplasmic reticulum in Alzheimer’s disease. Studies with cybrids
n.a.
Investigador
Center for Neurosciences and Cell Biology, University of Coimbra, Portugal
 L’Oréal Portugal/UNESCO/FCT
Concluído

Projeto

Designação Financiadores
2021/01/01 - 2025/12/31 Centro de Inovação em Biomedicina e Biotecnologia - Laboratório Associado
LA/P/0058/2020
10.54499/LA/P/0058/2020
Universidade de Coimbra, Portugal

Universidade Nova de Lisboa ¿Laboratório de Instrumentação Engenharia Biomédica e Física da Radiação, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2021/01/01 - 2025/12/31 Center for Innovative Biomedicine and Biotechnology - Associate Laboratory
LA/P/0058/2020
Universidade de Coimbra, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2019/01/01 - 2019/12/31 CNC. IBILI
UID/NEU/04539/2019
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Coimbra, Portugal

Universidade de Coimbra Instituto de Ciências Nucleares Aplicadas à Saúde, Portugal

Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2015 - 2018 Funding of RD Units Strategic Plan - 2013/2015 - OE
UID/NEU/04539/2013
Investigador
Center for Neurosciences and Cell Biology, University of Coimbra, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2013 - 2014 Concurso para Financiamento de Projectos de IC&DT Estratégicos e de Interesse Público promovidos por Laboratórios Associados e Unidades de I&D - 2013 - COMPETE
PEst-C/SAU/LA0001/2013
Investigador
Center for Neurosciences and Cell Biology, University of Coimbra, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2011/01/01 - 2012/12/31 Strategic Project - LA 1 - 2011-2012
PEst-C/SAU/LA0001/2011
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
Produções

Publicações

Artigo em conferência
  1. Mshelia, Philemon Paul; Napoli, Francesca; de Luca, Pasqualino; Costa, Rui O.; Mele, Miranda; Duarte, Carlos B.. "The Role of BDNF-TrkB Signalling in the Synaptic Expression of NMDA Receptors in Pilocarpine Model of Temporal Lobe Epilepsy". 2025.
  2. Ferreira I.L.; Mota S.I.; Costa RO; Padovano C.; Fonseca A.C.; Letra L.; Oliveira C.R.; et al. "Injury markers in peripheral blood mononuclear cells from mild cognitive impairment and Alzheimer’s disease patients". Trabalho apresentado em AD/PD 2011, Barcelona, 2011.
    Publicado
  3. Costa RO; P.N. Lacor; I.L. Ferreira; A.C. Rego; W.L. Klein; C. Pereira. "Role of N-Methyl-D- Aspartate receptors in endoplasmic reticulum stress induced by amyloide peptide oligomers". Trabalho apresentado em AD/PD 2009, Prague, 2009.
    Publicado
  4. Elisabete Ferreiro; Rosa Resende; Costa RO; P Moreira; Sandra Cardoso; Cláudia Pereira; CR Oliveira. "Neurodegeneration in Alzheimer's disease: Inter-organelle cross-talk and oxidative stress in cell life and death decisions". Trabalho apresentado em European Meeting of the Society-for-Free-Radical-Research-Europe, 2007.
    Publicado
  5. Costa, R.; Ferreiro, E.; Oliveira, C. R.; Pereira, C.. "Does mitochondria impairment affect endoplasmic reticulum function during amyloid-beta toxicity?". 2007.
  6. Elisabete B. Ferreiro; Costa RO; Catarina R. Oliveira; Cláudia M. Pereira. "P3–218: Crosstalk between the endoplasmic reticulum and mitochondria in amyloid–beta–induced apoptotic death". 2006.
    10.1016/J.JALZ.2006.05.1487
Artigo em revista
  1. Lourinho, Afonso; Silva, Marta; Tahiri, Emanuel; Pinto, Ana; Caniceiro, Beatriz; Moreira, Irina; Duarte, Carlos B; Costa, Rui O. Autor correspondente: Costa, Rui O. "RNArchitects: how hnRNPs shape neuronal landscapes". Brain (2025): https://doi.org/10.1093/brain/awaf448.
    Aceite para publicação • 10.1093/brain/awaf448
  2. De Luca, Pasqualino; Mele, Miranda; Tanqueiro, Sara; Napoli, Francesca; Butkeviciute, Ugné; Souto, Arthur C.; Costa, Rui O.; et al. "Synaptic accumulation of GluN2B-containing NMDA receptors mediates the effects of BDNF-TrkB signalling on synaptic plasticity and in hyperexcitability during status epilepticus". Journal of Biomedical Science 32 1 (2025): https://doi.org/10.1186/s12929-025-01164-4.
    10.1186/s12929-025-01164-4
  3. Tomé, Diogo; Martins, Luís F.; Aroso, Miguel; Santos, Henrique; Costa, Rui O.; Afonso, João L.; Serra, Sofia C.; et al. "Mesenchymal stromal cell secretome-induced synaptogenesis is mediated by thrombospondin-1". iScience 28 9 (2025): 113401. https://doi.org/10.1016/j.isci.2025.113401.
    10.1016/j.isci.2025.113401
  4. Salazar, Ivan L.; Curcio, Michele; Mele, Miranda; Vetrone, Rossela; Frisari, Simone; Costa, Rui O.; Caldeira, Margarida V.; Trader, Darci J.; Duarte, Carlos B.. "Activation of the 20S proteasome core particle prevents cell death induced by oxygen- and glucose deprivation in cultured cortical neurons". Apoptosis 30 5-6 (2025): 1372-1390. https://doi.org/10.1007/s10495-025-02097-x.
    10.1007/s10495-025-02097-x
  5. Rui O. Costa; Luís F. Martins; Emanuel Tahiri; Carlos B. Duarte. "Brain-derived neurotrophic factor -induced regulation of RNA metabolism in neuronal development and synaptic plasticity". WIREs RNA (2022): https://doi.org/10.1002/wrna.1713.
    10.1002/wrna.1713
  6. Costa, Filipa J.; Dias, Marta S.; Costa, Rui O.; Pedro, Joana R.; Almeida, Ramiro D.. "Isolation and Culture of Chick Ciliary Ganglion Neurons". Journal of Visualized Experiments 162 (2020): http://dx.doi.org/10.3791/61431.
    10.3791/61431
  7. Costa, Rui O.; Martins, Helena; Martins, Luís F.; Cwetsch, Andrzej W.; Mele, Miranda; Pedro, Joana R.; Tomé, Diogo; et al. "Synaptogenesis Stimulates a Proteasome-Mediated Ribosome Reduction in Axons". Cell Reports 28 4 (2019): 864-876.e6. http://dx.doi.org/10.1016/j.celrep.2019.06.080.
    10.1016/j.celrep.2019.06.080
  8. Mele, Miranda; Costa, Rui O.; Duarte, Carlos B.. "Alterations in GABAA-Receptor Trafficking and Synaptic Dysfunction in Brain Disorders". Frontiers in Cellular Neuroscience 13 (2019): http://dx.doi.org/10.3389/fncel.2019.00077.
    10.3389/fncel.2019.00077
  9. Salazar, Ivan; Mele, Miranda; Caldeira, Margarida; Costa, Rui; Correia, Bárbara; Frisari, Simone; Duarte, Carlos. Autor correspondente: Duarte, Carlos. "Preparation of Primary Cultures of Embryonic Rat Hippocampal and Cerebrocortical Neurons". BIO-PROTOCOL 7 18 (2017): http://dx.doi.org/10.21769/bioprotoc.2551.
    10.21769/bioprotoc.2551
  10. Martins, L.F.; Costa, R.O.; Pedro, J.R.; Aguiar, P.; Serra, S.C.; Teixeira, F.G.; Sousa, N.; Salgado, A.J.; Almeida, R.D.. "Mesenchymal stem cells secretome-induced axonal outgrowth is mediated by BDNF". Scientific Reports 7 1 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85021292472&partnerID=MN8TOARS.
    10.1038/s41598-017-03592-1
  11. Costa, R.O.; Perestrelo, T.; Almeida, R.D.. "PROneurotrophins and CONSequences". Molecular Neurobiology (2017): 1-18. http://www.scopus.com/inward/record.url?eid=2-s2.0-85018273843&partnerID=MN8TOARS.
    10.1007/s12035-017-0505-7
  12. Graciano Leal; Diogo Comprido; Pasqualino de Luca; Eduardo Morais; Luís Rodrigues; Miranda Mele; Ana R. Santos; et al. "The RNA-Binding Protein hnRNP K Mediates the Effect of BDNF on Dendritic mRNA Metabolism and Regulates Synaptic NMDA Receptors in Hippocampal Neurons". eneuro 4 6 (2017): ENEURO.0268-17.2017. https://doi.org/10.1523/ENEURO.0268-17.2017.
    10.1523/ENEURO.0268-17.2017
  13. Pinto, M.J.; Pedro, J.R.; Costa, R.O.; Almeida, R.D.. "Visualizing K48 ubiquitination during presynaptic formation by ubiquitination-induced fluorescence complementation (UiFC)". Frontiers in Molecular Neuroscience 9 JUNE (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84978476683&partnerID=MN8TOARS.
    10.3389/fnmol.2016.00043
  14. Costa, R.O.; Mota, S.I.; Ferreira, I.L.; Santana, I.; Caldeira, G.L.; Padovano, C.; Fonseca, A.C.; et al. "Oxidative stress involving changes in Nrf2 and ER stress in early stages of Alzheimer's disease". Biochimica et Biophysica Acta - Molecular Basis of Disease 1852 7 (2015): 1428-1441. http://www.scopus.com/inward/record.url?eid=2-s2.0-84928128412&partnerID=MN8TOARS.
    10.1016/j.bbadis.2015.03.015
  15. Martins, I.; Gomes, S.; Costa, R.O.; Otvos, L.; Oliveira, C.R.; Resende, R.; Pereira, C.M.F.. "Leptin and ghrelin prevent hippocampal dysfunction induced by Aß oligomers". Neuroscience 241 (2013): 41-51. http://www.scopus.com/inward/record.url?eid=2-s2.0-84876430099&partnerID=MN8TOARS.
    10.1016/j.neuroscience.2013.02.062
  16. Costa, R.O.; Ferreiro, E.; Oliveira, C.R.; Pereira, C.M.F.. "Inhibition of mitochondrial cytochrome c oxidase potentiates Aß-induced ER stress and cell death in cortical neurons". Molecular and Cellular Neuroscience 52 (2013): 1-8. http://www.scopus.com/inward/record.url?eid=2-s2.0-84870349573&partnerID=MN8TOARS.
    10.1016/j.mcn.2012.09.005
  17. Ferreiro, E.; Baldeiras, I.; Ferreira, I.L.; Costa, R.O.; Rego, A.C.; Pereira, C.F.; Oliveira, C.R.. "Mitochondrial- and endoplasmic reticulum-associated oxidative stress in alzheimers disease: From pathogenesis to biomarkers". International Journal of Cell Biology (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84863688106&partnerID=MN8TOARS.
    10.1155/2012/735206
  18. Costa, R.O.; Ferreiro, E.; Martins, I.; Santana, I.; Cardoso, S.M.; Oliveira, C.R.; Pereira, C.M.F.. "Amyloid ß-induced ER stress is enhanced under mitochondrial dysfunction conditions". Neurobiology of Aging 33 4 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84856951448&partnerID=MN8TOARS.
    10.1016/j.neurobiolaging.2011.04.011
  19. Costa, R.O.; Lacor, P.N.; Ferreira, I.L.; Resende, R.; Auberson, Y.P.; Klein, W.L.; Oliveira, C.R.; Rego, A.C.; Pereira, C.M.F.. "Endoplasmic reticulum stress occurs downstream of GluN2B subunit of N-methyl-d-aspartate receptor in mature hippocampal cultures treated with amyloid-ß oligomers". Aging Cell 11 5 (2012): 823-833. http://www.scopus.com/inward/record.url?eid=2-s2.0-84866452758&partnerID=MN8TOARS.
    10.1111/j.1474-9726.2012.00848.x
  20. Costa, R.O.; Ferreiro, E.; Cardoso, S.M.; Oliveira, C.R.; Pereira, C.M.F.. "ER stress-mediated apoptotic pathway induced by aß peptide requires the presence of functional mitochondria". Journal of Alzheimer's Disease 20 2 (2010): 625-636. http://www.scopus.com/inward/record.url?eid=2-s2.0-77954516455&partnerID=MN8TOARS.
    10.3233/JAD-2010-091369
  21. Ferreiro, E.; Costa, R.; Marques, S.; Cardoso, S.M.; Oliveira, C.R.; Pereira, C.M.F.. "Involvement of mitochondria in endoplasmic reticulum stress-induced apoptotic cell death pathway triggered by the prion peptide PrP 106-126". Journal of Neurochemistry 104 3 (2008): 766-776. http://www.scopus.com/inward/record.url?eid=2-s2.0-38049162500&partnerID=MN8TOARS.
    10.1111/j.1471-4159.2007.05048.x
  22. Ferreiro, E.; Resende, R.; Costa, R.; Oliveira, C.R.; Pereira, C.M.F.. "An endoplasmic-reticulum-specific apoptotic pathway is involved in prion and amyloid-beta peptides neurotoxicity". Neurobiology of Disease 23 3 (2006): 669-678. http://www.scopus.com/inward/record.url?eid=2-s2.0-33747195017&partnerID=MN8TOARS.
    10.1016/j.nbd.2006.05.011
Capítulo de livro
  1. Costa, Rui O.; Perestrelo, Tânia; Tomé, Diogo; Almeida, Ramiro D.. "A Microfluidic Culture Platform for Neurotrophin Signaling Studies". In Brain-Derived Neurotrophic Factor (BDNF), 185-201. Springer New York, 2018.
    Publicado • 10.1007/7657_2018_9
  2. Elisabete Ferreiro; Costa RO; Sueli Marques; Catarina Resende de oliveira; Pereira, Cláudia Maria Pereira. "ROLE OF ENDOPLASMIC RETICULUM-MEDIATED APOPTOTIC PATHWAY IN Ab TOXICITY". In Cognitive Sciences at the leading Edge, 67-82. NY, Estados Unidos: Nova Science Publishers, Inc.,, 2008.
    Publicado
Manual
  1. Santos-Carvalho, Ana; Rui O Costa; Maria Inês Morte; Pedro Alves. Fisiologia Celular e Biologia Molecular. Portugal. 2013.
Poster em conferência
  1. Costa RO. Autor correspondente: Costa RO. "Breaking the flow: how amyloid-ß disrupts axonal autophagy in early Alzheimer’s disease". Trabalho apresentado em ESN-ISN Joint Meeting, Naxos, Greece, 18-21 May 2025, 2025.
  2. Silva, Marta; Duarte, Carlos B.; Costa, Rui. "The RNA-binding protein hnRNP H2: a novel player in neurodevelopmental disorders and epileptogenesis". Trabalho apresentado em iMed Conference 15.0, 2023.
  3. Tahiri, Emanuel; Alexandra Filipa almeida Santos; Marta Sofia Santos Silva; Carlos Jorge Alves Miranda Bandeira Duarte; Costa, Rui. Autor correspondente: Costa, Rui. "Intra-axonal autophagosome biogenesis impairment in Alzheimer’s disease". Trabalho apresentado em ISN-ESN 2023 Porto, Portugal, 2023.
  4. Tahiri, Emanuel; Alexandra Santos; Marta Silva; Carlos Jorge Alves Miranda Bandeira Duarte; Costa, Rui. Autor correspondente: Costa, Rui. "Autophagy dysfunction in axons: a trigger for Alzheimer’s disease?". Trabalho apresentado em BEB DAY 2023 in Coimbra on the days 7th and 8th of February (https://cnc.uc.pt/en/pdbeb/beb-news/beb-day-2023-1), 2023.
  5. Claudia Corso; Giorgio Belperio; Cinzia Miarelli; Rodrigues, Catarina; Filipe Duarte; Costa, Rui; Duarte, Carlos B.; Mele, Miranda. "K+-Cl- cotransporter (KCC2) activation as a novel therapeutic strategy for epilepsy". Trabalho apresentado em 8th European Synapse Meeting, 20th-21st of October 2022. Coimbra, 2022.
  6. Tomé D; Martins LF; Costa RO; Serra SC; Duarte CB; Pinheiro PS; Salgado AJ; Almeida RD. "Regenerative and synaptogenic effect of human umbilical cord perivascular cells secretome in central nervous system neurons". Trabalho apresentado em VIII European Synapse Meeting (Coimbra, Portugal), 2022.
  7. Tahiri, Emanuel; Alexandra Santos; Duarte, Carlos B.; Costa RO. Autor correspondente: Costa RO. "Intra-axonal autophagy dysfunction: an early event in Alzheimers disease". Trabalho apresentado em XVII Meeting of the Portuguese Society for Neuroscience ¿ SPN2021 #NNR-71, 2021.
  8. Costa RO; Tomé, Diogo; Martins, Luís; Lia G Carvalhais; Sofia C Serra; Paulo S Pinheiro; Duarte, Carlos B.; Antonio J Salgado; Almeida, Ramiro D. "Synaptogenic effect of human umbilical cord perivascular cells secretome in central nervous system". Trabalho apresentado em XVII Meeting of the Portuguese Society for Neuroscience – SPN2021, 2021.
  9. Guilherme G Trigo; Joana R Pedro; Diogo Tomé; Costa RO; Ramiro D Almeida. "Intra-axonal mRNA translation occurs at discrete “hot spots” during synapse formation". 2021.
  10. Filipe Valente Duarte; Belperio, Giorgio; Cinzia Miarelli; Giovanna Lombardi; Duarte, Carlos B.; Costa RO; Mele, Miranda. "Activation of K+-Cl--cotransporter (KCC2) as a novel therapeutic approach for epilepsy". Trabalho apresentado em XVII Meeting of the Portuguese Society for Neuroscience – SPN2021, 2021.
  11. Tomé D; Martins LF; Carvalhais LG; Costa RO; Serra SC; Pinheiro PS; Duarte CB; Salgado AJ; Almeida RD. "Synaptogenic effect of human umbilical cord perivascular cells secretome in central nervous system neurons". Trabalho apresentado em XVII Meeting of the Portuguese Society for Neuroscience (Coimbra, Portugal), 2021.
  12. Costa RO; Tahiri, Emanuel; Marta Silva; Duarte, Carlos B.. Autor correspondente: Costa RO. "Intra-axonal autophagy dysfunction in Alzheimer’s disease". Trabalho apresentado em EMBO Workshop Axons 2021; structure and function, 2021.
  13. Miranda Mele; Cinzia Miarelli; Giorgio Belperio; Giovanna Lombardi; Filipe Valente Duarte; Costa RO; Carlos B. Duarte. "K+-Cl--cotransporter (KCC2) as a novel therapeutic strategy for epilepsy". Trabalho apresentado em Congresso Virtual da LPCE - 33º eENE, 2021.
  14. Diogo Tomé; Luís F. Martins; Costa RO; Sofia C. Serra, Nuno Sousa, António J. Salgado & Ramiro D. Almeida. "Mesenchymal stem cells secretome induces synapse formation in central nervous system neurons.". Trabalho apresentado em Secretive With]Out[ Borders meeting, Braga, Portugal, 6- 7th December, 2018., 2018.
  15. Costa RO; Helena Martins, Luís F. Martins, Joana R. Pedro, Miranda Mele, Andrzej Cwetsch, Laura Cancedda, Ramiro D.. "Mechanisms underlying ribosomal regulation in axonal development". Trabalho apresentado em ISN 2016 meeting, Coimbra, Portugal, June 1st-4th, 2016., 2016.
  16. Luís F. Martins; Costa RO; Susana Sampaio, Joana Pedro, Sofia Serra, Nuno Sousa, António Salgado, Ramiro Almeida. "Mesenchymal stromal cells secretome-induced axonal outgrowth is mediated by BDNF". Trabalho apresentado em ISN 2016 meeting, Coimbra, Portugal, June 1st-4th, 2016, 2016.
  17. Joana Pedro; Maria Joana Pinto; Costa RO; Pedro Alves, Hyun Ryu, Noo Li Jeon Samie Jaffrey & Ramiro Almeida. "Presynaptic differentiation triggered by target-derived cue is mediated by local protein synthesis". Trabalho apresentado em ISN 2016 meeting, Coimbra, Portugal, June 1st-4th, 2016, 2016.
  18. Costa RO; Joana R. Pedro, Maria Joana Pinto, Hyun R. Ryu, Noo Li Jeon, Samie R. Jaffrey & Ramiro D. Almeida. "Intra-axonal translation is required for synapse formation". Trabalho apresentado em SFN 2014 meeting, Washington DC, USA, November 15th-19th, 2014, 2014.
  19. Joana R. Pedro; Maria Joana Pinto; Costa RO; Hyunryul Ryu, Noo Li Jeon, Samie Jaffrey & Ramiro D. Almeida. "Intra-axonal translation of ß-actin is required for presynaptogenesis". Trabalho apresentado em 4th European synapse meeting, Bordeux, France August 28th-30th, 2013, 2013.
  20. Joana R. Pedro; Costa RO; Maria Joana Pinto, Hyunryul Ryu, Noo Li Jeon, Samie Jaffrey & Ramiro D. Almeida. "The role of axonal local translation in presynaptogenesis: the role of ß-actin". Trabalho apresentado em 9th FENS forum of Neuroscience, Milan, Italy, July 5th-9th, 2013, 2013.
  21. Joana R. Pedro; Costa RO; Maria Joana Pinto; Hyunryul Ryu; Noo Li Jeon; Samie Jaffrey; Ramiro D. Almeida. "The role of axonal local translation in presynaptogenesis: the role of ß-actin". Trabalho apresentado em 9th FENS forum of Neuroscience, 2013.
  22. Rego, A. Cristina; Mota, S.I.; Costa, Rui; Caldeira, Gladys Lima; Santana, Isabel; Padovano, C.; Ana Catarina RG Fonseca; et al. "Oxidative and ER stress in early stages of Alzheimer’s disease". Trabalho apresentado em XIII Reunião da Sociedade Portuguesa de Neurociências, 2013.
  23. Joana R. Pedro; Costa RO; Maria Joana Pinto, Hyunryul Ryu, Noo Li Jeon, Samie Jaffrey & Ramiro D. Almeida. "The role of axonal local translation in presynaptogenesis: the role of ß-actin.". Trabalho apresentado em CNC meeting, Biocant, Cantanhede, December 19th-20th, 2012, 2012.
  24. Mota, S.I.; Costa RO; Caldeira G.L., Santana I., Padovano C., Fonseca A.C., Letra L., Oliveira C., Ferreira I.L., Perei. "Nrf2 downregulation-mediated oxidative stress and ER stress in early stages of Alzheimer’s disease". Trabalho apresentado em Neurodegenerative Diseases Meeting, Cold Spring Harbor, New York, USA, Nov 28th-Dec 1st, 2012. *equal contibution, 2012.
  25. Mota, S.I.; Costa, Rui; Santana, Isabel; Padovano, C.; Ana Catarina RG Fonseca; Caldeira, Gladys Lima; Letra, L.; et al. "Changes in oxidative and endoplasmic reticulum stress in human peripheral blood mononuclear cells during early stages of Alzheimer’s disease". Trabalho apresentado em 26ª Reunião do Grupo de Estudos de Envelhecimento Cerebral e Demência, 2012.
  26. Fonseca A.C.; Ferreira I.L.; Costa RO; Mota S.I., Padovano C., Letra L., Oliveira C.R., Santana I., Pereira C., Rego A.C. "Increased susceptibility to cell death following early peripheral endoplasmic reticulum and oxidative stress in Alzheimer’s disease patients". Trabalho apresentado em Sinal, 5th Annual Meeting on Cell Signalling, Coimbra, Portugal, April 29th-30st, 2011, 2011.
  27. Ferreira I.L.; Mota S.I.; Costa RO; Padovano C., Fonseca A.C., Letra L., Oliveira C.R., Santana I., Pereira C., Rego A.C. "Injury markers in peripheral blood mononuclear cells from mild cognitive impairment and Alzheimer’s disease patients". Trabalho apresentado em 10th International Conference AD/PD, Barcelona, Spain, March 9th-13th, 2011, 2011.
  28. Martins I.; Gomes S.; Costa RO; Martins I., Gomes S., Costa R.O., Resende R., Oliveira C.R., Pereira C.M.. "Effect of leptin and ghrelin in hippocampal neurons against Alzheimer ´s disease neurotoxins – amyloid-beta peptide". Trabalho apresentado em XVII National Congress of Biochemistry, Oporto, Portugal, December 15th-17th, 2010, 2010.
  29. Martins, Isaura; Gomes, Sílvia; Costa, Rui; Resende, Rosa; Oliveira, Catarina R; Pereira, Cláudia Fragão. "Ghrelin and leptin protect hippocampal neurons against Aß-induced toxicity. Relevance for therapeutic intervention in Alzheimer’s disease.". Trabalho apresentado em XVII National Congress of the Portuguese Biochemical Society, 2010.
  30. Martins I.; Gomes S.; Costa RO; Resende R., Oliveira C.R., Pereira C.M.. "Ghrelin and leptin protect hippocampal neurons and hypothalamic cells against Aß-induced toxicity. Relevance for therapeutic intervention in Alzheimer ´s disease.". Trabalho apresentado em 2nd National Meeting on Medicinal Chemistry, Coimbra, Portugal, November 28th-30th 2010, 2010.
  31. Costa RO; Lacor P.N., Klein W.L., Rego A.C. and Pereira C.. "Alzheimer’s disease-associated amyloid-peptide oligomers induce endoplasmic reticulum stress through N-methyl-D- aspartate receptors in hippocampal neurons.". Trabalho apresentado em 7th FENS, Forum of European Neuroscience, Amsterdam, The Neatherlands, July 3rd-7th, 2010, 2010.
  32. Elisabete Ferreiro; Costa RO; Sandra Morais Cardoso, Catarina Resende de Oliveira e Cláudia Pereira.. "ER stress-mediated apoptotic pathway induced by Aß1-40 peptide requires the presence of functional mitochondria". Trabalho apresentado em 7th FENS, Forum of European Neuroscience, Amsterdam, The Netherlands, July 3rd-7th, 2010, 2010.
  33. Martins I.; Gomes S.; Costa RO; Resende R., Oliveira C.R., Pereira C.M. "Leptin and Ghrelin protect against Aß-induced toxicity in hippocampal and hypothalamic neurons". Trabalho apresentado em Final Annual Network Meeting, ENINET, Coimbra, Portugal, May 6th-8th, 2010, 2010.
  34. Oliveira C.R.,; Ferreira I.L.; Costa RO; Mota S.I., Bajouco M., Lacor P.N., Klein W.L., Rego A.C., Pereira C.. "Binding of amyloid-beta oligomers to NR2B subunits is associated with endoplasmic reticulum stress in hippocampal neurons". Trabalho apresentado em 39th Annual Meeting of the American Society for Neuroscience (SFN). Chicago, USA, October 17th-21th, 2009., 2009.
  35. Costa RO; Ferreira IL, Rego AC, Klein WL, Pereira C.. "Role of N-methyl-D-aspartate receptors in endoplasmic reticulum stress induced by Aß oligomers". Trabalho apresentado em 9th Internacional Conferente on Alzheimer’s and Parkinson’s Diseases (AD/PD), Prague, Czech Republic. March 11th -15th, 2009, 2009.
  36. Elisabete Ferreiro; Costa RO; Rosa Resende, Sueli Marques, Sandra Morais Cardoso, Catarina Resende de Oliveira e Cláudi. "Communication between endoplasmic reticulum and mitochondria in neuronal death induced by amyloid-beta peptide.". Trabalho apresentado em 5th International Congress on Vascular Dementia, Budapest, Hungary, November 8th-11th, 2008, 2008.
  37. Pereira C.,; Ferreiro E.; Costa RO; Resende R., Cardoso S., Oliveira C.R. "Cross-talk between endoplasmic reticulum and mitochondria in the neurotoxicity induced by Alzheimer’s disease- associated beta-amyloid peptide". Trabalho apresentado em 11th International Conference on Alzheimer’s Disease and Related Disorders. Chicago, USA, 26th-31st July, 2008, 2008.
  38. Costa RO; Elisabete Ferreiro, Catarina Resende de Oliveira e Cláudia Pereira. "Amyloid-beta-induced ER stress under conditions of mitochondrial respiratory chain inhibition.". Trabalho apresentado em 6th FENS, Forum of European Neuroscience, Geneva, Switzerland. June 12th-16th, 2008, 2008.
  39. Ferreiro, Elisabete; Rui O Costa; Rosa Resende; Sueli Marques; Sandra Morais Cardoso; Catarina Resende de Oliveira; Cláudia Maria Fragão Pereira. "Communication between endoplasmic reticulum and mitochondria in the neuronal death induced by amyloid-beta peptide". Trabalho apresentado em Fifth International Congress on Vascular Dementia, Budapest, Hungary, 2007.
  40. Costa RO; Elisabete Ferreiro, Catarina Resende de Oliveira, Cláudia Pereira. "Interaction between mitochondria and endoplasmic reticulum during amyloid-beta peptide toxicity associated to Alzheimer´s disease". Trabalho apresentado em 10th Meeting of the Portuguese Society for Neurosciences, Ofir, Portugal, May 25th, 2007, 2007.
  41. Elisabete Ferreiro; Costa RO; Catarina R. Oliveira, Cláudia Pereira. "Mitochondrial dysfunction potentiates endoplasmic reticulum stress. Studies on Alzheimer’s disease cybrids.". Trabalho apresentado em 8th International Conference on Alzheimer’s and Parkinson’s Diseases (AD/PD), Salzburg, Austria, March 15th-18th, 2007, 2007.
  42. Elisabete Ferreiro; Costa RO; Catarina Resende de Oliveira, Cláudia Pereira. "Retículo endoplasmático e mitocôndria na doença de Alzheimer". Trabalho apresentado em XV National Congresss of Biochemistry, Aveiro, Portugal, December 8th-10th, 2006, 2006.
  43. Elisabete Ferreiro; Costa RO; Catarina Resende de Oliveira, Cláudia Pereira. "Mitochondria is required for ER-mediated apoptotic pathway induced by A-beta peptide". Trabalho apresentado em XV National Congresss of Biochemistry, Aveiro, Portugal, December 8th-10th, 2006, 2006.
  44. Ana Gouveia; Elisabete Ferreiro; Costa RO; Catarina Resende de Oliveira, Cláudia Pereira. "“Cross-talk” entre o retículo endoplasmático e a mitocôndria na doença de Alzheimer.". Trabalho apresentado em V Congresso de Investigação em Medicina, Coimbra, Portugal. November 23rd-24th, 2006., 2006.
  45. Elisabete Ferreiro; Costa RO; Catarina Resende de Oliveira e Cláudia Pereira. "Crosstalk between the endoplasmic reticulum and mitochondria in amyloid-beta-induced apoptotic death". Trabalho apresentado em 10th International Conference on Alzheimer’s disease and related disorders, Madrid, Spain, July 15th-20th, 2006, 2006.
Pré-impressão
  1. Pasqualino De Luca; Miranda Mele; Francesca Napoli; Philemon Mshelia; Rui O. Costa; Carlos B. Duarte. "BDNF-TrkB signaling promotes synaptic GluN2A-NMDA receptor expression and network hyperexcitability in cultured hippocampal neurons and during status epilepticus". 2025. https://doi.org/10.1101/2025.10.13.682007.
    10.1101/2025.10.13.682007
  2. Tahiri, Emanuel; Silva, Marta; Costa RO. Autor correspondente: Costa RO. "When Brain Wiring Gets Tricky: Understanding Neurodevelopmental Disorders". 2025. https://kids.frontiersin.org.
Resumo em conferência
  1. Costa RO. "The Role of BDNF-TrkB Signalling in the Synaptic Expression of NMDA Receptors in Pilocarpine Model of Temporal Lobe Epilepsy". Trabalho apresentado em ISN–ASN 2025 Meeting in New York City, USA, New York, 2025.
  2. Costa RO. Autor correspondente: Costa RO. "Intra-axonal autophagosome biogenesis impairment in Alzheimer's disease". Trabalho apresentado em Journal of Neurochemistry. Volume 166, Page 139-139, Supplement 1, Special Issue SI, Meeting Abstract B 10-29. Accession Number WOS:001057599800316, ISSN 0022-3042, eISSN 1471-4159, 2023.
  3. Das, Gautami. "10th Alzheimer's disease/Parkinson's disease (AD/PD) Conference". 2011.
    10.5214/ANS.0972.7531.1118210
  4. Costa RO; Lacor, P.N.; Klein, W.L.; Rego AC; Cláudia Pereira. "Alzheimers disease-associated amyloide peptide oligomers induce endoplasmic reticulum stress throught N-Methyl-D- Aspartate receptors in hippocampal neurons". Trabalho apresentado em Federation of European Neuroscience Societies (2010), Amsterdam, 2010.
    Publicado
  5. Ferreiro, E.; Rui O Costa; Resende, R.; Marques, S.; Cardoso, S.; Oliveira, C.R.; Pereira, C.. "10.1016/j.jns.2009.02.158 Communication between endoplasmic reticulum and mitochondria in the neuronal death induced by amyloid-beta peptide". Trabalho apresentado em 5th International Congress on Vascular Dementia, Budapest, 2009.
    Publicado • 10.1016/j.jns.2009.02.158
  6. Pereira, Cláudia M.F.; Ferreiro, Elisabete B.; Rui O Costa; Resende, Rosa M.M.B.; Cardoso, Sandra M.; Oliveira, Catarina R.. "10.1016/j.jalz.2008.05.1011 P1-429: Cross-talk between endoplasmic reticulum and mitochondria in the neurotoxicity induced by Alzheimer's disease-associated beta-amyloid peptide". Trabalho apresentado em 11ª International conference on Alzheimer's Disease and Reletaded Disorders, Chicago, 2008.
    Publicado • 10.1016/j.jalz.2008.05.1011
  7. Costa RO; Elisabete Ferreiro; CR Oliveira; Cláudia Pereira. "Amyloid-beta-induced ER stress under conditions of mitochondrial respiratory chain inhibition". Trabalho apresentado em Federation of European Neuroscience Societies (FENS), Geneva, 2008.
    Publicado
Tese / Dissertação
  1. "RNA-binding protein hnRNPH2: The role of RRM and NLS mutations in neuronal development and function". Mestrado, Universidade de Coimbra, 2025. 2024-2025. Student: Ana Pinto. Thesis title: “RNA-binding protein hnRNPH2: The role of RRM and NLS mutations in neuronal development and function.” Faculty of medicine, University of Coimbra. MSc's Thesis in Molecular and translational neuroscience. Role: Supervisor. https://hdl.handle.net/10316/121173.
  2. "RNA-binding protein hnRNPH2: The role of NLS mutations in neuronal development and function". Mestrado, Universidade de Coimbra, 2025. 1. 2024-2025. Student: Afonso Lourinho. Thesis title: “RNA-binding protein hnRNPH2: The role of NLS mutations in neuronal development and function.” Department of Life Sciences, Faculty of Science and Technology, University of Coimbra. MSc's Thesis in Cellular and Molecular Biology. Role: Supervisor. https://hdl.handle.net/10316/120572.
  3. "The Role of HNRNP H2 mutations in Epileptogenesis". Mestrado, Università degli Studi di Napoli Federico II, 2025. 2024-2025. Student: Marco D'Ambrosio. Thesis title: “The Role of HNRNP H2 mutations in Epileptogenesis.” Università degli Studi di Napoli Federico II Università degli Studi del Sannio (Italy). Dipartimento di Scienze e Tecnologie dell’Università del Sannio Tesi di Laurea Magistrale in Farmacologia Molecolare. Corso di Laurea Magistrale in Biotecnologie Genetiche e Molecolari. Classe LM-9 delle Lauree Magistrali in Biotecnologie Mediche, Veterinarie e Farmaceutiche. Laurea Magistrale rilasciata in forma congiunta. Tesi di Laurea Magistrale in Farmacologia Molecolare. Role: Supervisor.
  4. "Characterisation of the RNA-binding protein hnRNP H2: a novel player in epileptogenesis". Mestrado, Universidade de Coimbra, 2023. 2. 2022-2023. Student: Marta Silva. Thesis title: “Characterisation of the RNA-binding protein hnRNP H2: a novel player in epileptogenesis.” Department of Life Sciences, Faculty of Science and Technology, University of Coimbra. MSc's Thesis in Cellular and Molecular Biology. Role: Supervisor. https://hdl.handle.net/10316/110348.
  5. "Autophagosome biogenesis and axonal transport dysfunction in Alzheimer's disease". Mestrado, Universidade de Coimbra, 2022. 2. 2021-2022. Student: Alexandra Santos. Thesis title: “Autophagosome biogenesis and axonal transport dysfunction in Alzheimer's disease.” Department of Life Sciences, Faculty of Science and Technology, University of Coimbra. MSc's Thesis in Cellular and Molecular Biology. Role: Supervisor. https://estudogeral.uc.pt/handle/10316/102862.
  6. "The impact of early life stress on anxiety and depression later in life: the contribution of MeCP2". Mestrado, Universidade de Coimbra, 2022. 2021-2022. Student: Francisca Madeira. Thesis title: "The impact of early life stress on anxiety and depression later in life: the contribution of MeCP2.” Department of life Sciences, Faculty of Science and Technology, University of Coimbra. MSc's Thesis in Cellular and Molecular Biology. Role: Co-Supervisor. https://estudogeral.uc.pt/handle/10316/103157.
  7. "The role of the heterogeneous ribonucleoprotein H2 in neuronal development". Mestrado, Università degli Studi di Napoli Federico II, 2022. 2021-2022. Student: Giovanna Di Pietro. Thesis title: “The role of the heterogeneous ribonucleoprotein H2 in neuronal development.” Università degli Studi di Napoli Federico II Università degli Studi del Sannio (Italy). Dipartimento di Scienze e Tecnologie dell’Università del Sannio Tesi di Laurea Magistrale in Farmacologia Molecolare. Corso di Laurea Magistrale in Biotecnologie Genetiche e Molecolari. Classe LM-9 delle Lauree Magistrali in Biotecnologie Mediche, Veterinarie e Farmaceutiche. Laurea Magistrale rilasciata in forma congiunta. Tesi di Laurea Magistrale in Farmacologia Molecolare. Role: Supervisor..
  8. "Novel roles for the KCC2 co-transporter in axons: regulation of chloride homeostasis and growth cone development". Mestrado, Università degli Studi di Napoli Federico II, 2021. 2019-2020. Student: Giorgio Belperio. Thesis title: “Novel roles for the KCC2 co-transporter in axons: regulation of chloride homeostasis and growth cone development.” Università degli Studi di Napoli Federico II Università degli Studi del Sannio (Italy). Dipartimento di Scienze e Tecnologie dell’Università del Sannio Tesi di Laurea Magistrale in Farmacologia Molecolare. Corso di Laurea Magistrale in Biotecnologie Genetiche e Molecolari. Classe LM-9 delle Lauree Magistrali in Biotecnologie Mediche, Veterinarie e Farmaceutiche. Laurea Magistrale rilasciata in forma congiunta. Tesi di Laurea Magistrale in Farmacologia Molecolare. Role: Supervisor..
  9. "Determine if intra-axonal mRNA translation occurs at discrete “hot spots” during synapse formation". Mestrado, Universidade de Aveiro, 2021. 2020-2021. Student: Guilherme Trigo. “Determine if intra-axonal mRNA translation occurs at discrete “hot spots” during synapse formation.” (2020-2021). Department of Medical Sciences, University of Aveiro. MSc's Thesis in Molecular Biomedicine. Role: Co- Supervisor. http://hdl.handle.net/10773/33029.
  10. "Alteration of neuronal networks in epilepsy: the role of the K+-Cl- cotransporter KCC2.". Mestrado, Università degli Studi del Sannio, 2021. 2020-2021. Student: Claudia Corso. “Alteration of neuronal networks in epilepsy: the role of the K+-Cl- cotransporter KCC2.” Dipartimento di Scienze e Tecnologie, Corso di Laurea Magistrale in Biologia, Università degli studi del Sannio (Italy). Tesi di Laurea Magistrale in Basi farmacologiche della terapia. Role: Co-Supervisor..
  11. "Early autophagy dysfunction in Alzheimer’s disease: the role of Wipi2.". Mestrado, Universidade de Coimbra, 2021. 2020-2021. Student: Emanuel Tahiri. “Early autophagy dysfunction in Alzheimer’s disease: the role of Wipi2.” Department of life Sciences, Faculty of Science and Technology, University of Coimbra. MSc's Thesis in Cellular and Molecular Biology. Role: Supervisor. https://estudogeral.uc.pt/handle/10316/99427.
  12. "Ribosomal regulation Axonal development". Licenciatura, Universidade de Coimbra, 2014. Student: Helena Sofia Caria Martins. Thesis title: “Ribosomal regulation Axonal development.” Department of life Sciences, Faculty of Science and Technology, University of Coimbra. MSc's Thesis in Cellular and Molecular Biology. Role: Co-supervisor. https://hdl.handle.net/10316/30759.
  13. "Endoplasmic reticulum stress during amyloid ß peptide-induced cell death : role of mitochondria and glutamatergic N-methyl-D-aspartate receptors". Doutoramento, Universidade de Coimbra, 2011. http://hdl.handle.net/10316/18243.
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2025/01/31 The RNA-binding protein hnRNPH2: a novel player in epileptogenesis. HNRNP-RNDD Virtual Scientific Symposium. International meeting
2024/12/20 The RNA-binding protein hnRNPH2: a novel player in epileptogenesis. CiBB meeting 2024 - Flash talks, December 20, 2024.
CiBB meeting 2024 - Flash talks, December 20, 2024. (Anadia, Portugal)
2024/03/08 The RNA-binding protein hnRNPH2: a novel player in epileptogenesis. Rui received the award for best oral communication. 36th National Epileptology Meeting (ENE), Coimbra, Portugal
Liga Portuguesa contra a Epilepsia (Coimbra, Portugal)
2024 Unravelling the impact of amyloid-ß oligomers on intra-axonal autophagy dysregulation in Alzheimer's disease Emanuel Tahiri, Alexandra Santos, Marta Silva, Carlos Bandeira Duarte, Rui O. Costa. 38a Reunião do Grupo de Estudos de Envelhecimento Cerebral e Demência
(braga, Portugal)
2023/12/12 How to study a Rare Neurodevelopmental disorder?” Department of Life Sciences (DCV) Talks, University of Coimbra, Coimbra, Portugal.
Department of Life Sciences (DCV) Talks, University of Coimbra, Coimbra, Portugal. (Coimbra, Portugal)
2023/11/04 Strategies to study intra-axonal neurodegenerative mechanisms in Alzheimer's disease ISN-ESN Advanced School 2023
ISN-ESN Advanced School 2023 (Faro, Portugal)
2022/06 Amyloid-ß oligomers impair intra-axonal autophagy GEECD 2022
(Portugal)
2022/06 The role of intra-axonal autophagy in Alzheimer’s disease GEECD 2022
(Portugal)
2022/04/23 Da ideia à publicação dos resultados: Como se faz (neuro)ciência? MeetLAB (VI meet.Lab; https://pt-br.facebook.com/meet.LabCoimbra/)
Meet.LAB (Coimbra, Portugal)
2020/06/03 Synaptogenesis stimulates a proteasome-mediated ribosome reduction in axons Portuguese Postdoc exchange program
Instituto Gulbenkian de Ciência (ICG) - Portugal (WEBINAR, Portugal)
2017/02 Axonal regulation of ribosome content during development XLVII Reunião Anual da Sociedade Portuguesa de Farmacologia
Sociedade Portuguesa de Farmacologia (Coimbra, Portugal)
2017/02 Local application of MSCs secretome induces axonal elongation in CNS neurons XLVII Reunião Anual da Sociedade Portuguesa de Farmacologia
Sociedade Portuguesa de Farmacologia (Coimbra, Portugal)
2013/06 Oxidative and ER stress in early stages of Alzheimer’s disease 13a Reunião da Sociedade Portuguesa de Neurociências
Sociedade Portuguesa de Neurociências (Luso, Portugal)
2013/04 Excitotoxicity and oxidative stress in early stages of Alzheimer's Disease Oxidative Stress & Disease -The Metabolic-Inflammatory Axis in Brain Aging and Alzheimer's Disease Gordon Conference
Gordon Conference (Les Diablerets, Suiça)
2013/03/23 Alzheimer’s Disease: Biochemical Approaches to Molecular Mechanisms VI Encontro Nacional de Estudantes de Bioquímica
VI Encontro Nacional de Estudantes de Bioquímica (Aveiro, Portugal)
2012/06 Changes in oxidative and endoplasmic reticulum stress in human peripheral blood mononuclear cells during early stages of Alzheimer’s disease 26a Reunião Grupo de Estudos de Envelhecimento Cerebral e Demências
Grupo de Estudos de Envelhecimento Cerebral e Demências (Tomar, Portugal)
2012/03/17 Percurso académico e ciêntifico. O nosso actual trabalho laboratorial. Simpósio:Jovens cientistas no IEC
Instituto de Educação e Cidadania (IEC) (Mamarrosa, Oliveira do bairro, Portugal)
2010/06 Loss of endoplasmic reticulum calcium homeostasis in Alzheimer’s disease 24a Reunião Grupo de Estudos de Envelhecimento Cerebral e Demências
Grupo de Estudos de Envelhecimento Cerebral e Demências (Tomar, Portugal)
2010/06 Neuroprotection by leptin and ghrelin against amyloid-beta toxicity in hippocampal neurons. Relevance for therapeutic intervention in Alzheimer’s disease 24a Reunião Grupo de Estudos de Envelhecimento Cerebral e Demências
Grupo de Estudos de Envelhecimento Cerebral e Demências (Tomar, Portugal)
2010/06 Changes in NMDA receptor subunits expression in 3xTg-AD mice and human peripheral blood cells 24a Reunião Grupo de Estudos de Envelhecimento Cerebral e Demências
Grupo de Estudos de Envelhecimento Cerebral e Demências (Tomar, Portugal)
2009/06 Endoplasmic reticulum stress in hippocampal neurons induced by Alzheimer’s disease-Associated amyloid-beta oligomers. Role of NR2A and NR2B subunits of N-Methyl-D-ASpartate (NMDA) receptor 23a Reunião Grupo de Estudos de Envelhecimento Cerebral e Demências
Grupo de Estudos de Envelhecimento Cerebral e Demências (Luso, Portugal)
2008/06 O envolvimento mitocondrial na apoptose mediada pelo retículo endoplasmático na doença de Alzheimer 22a Reunião Grupo de Estudos de Envelhecimento Cerebral e Demências
Grupo de Estudos de Envelhecimento Cerebral e Demências (Luso, Portugal)
2007/06 Disfunção do retículo endoplasmático em cíbridos de doentes de Alzheimer 21a Reunião Grupo de Estudos de Envelhecimento Cerebral e Demências
Grupo de Estudos de Envelhecimento Cerebral e Demências (Luso, Portugal)
2006/12 Endoplasmic reticulum-specific apoptotic pathway induced by prion and amyloid-beta peptides. XXXVII Reunião Anual da Sociedade Portuguesa de Farmacologia e XXIV Reunião de Farmacologia Clínica
Sociedade Portuguesa de Farmacologia (Porto, Portugal)
2006/06 Role of mitochondria in the endoplasmic reticulum-mediated apoptosis induced by the amyloid-beta peptide 20a Reunião Grupo de Estudos de Envelhecimento Cerebral e Demências
Grupo de Estudos de Envelhecimento Cerebral e Demências (Tomar, Portugal)

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2024/03 - Atual Study the role of ATG16 in intra-axonal autophagy in Alzheimer’s disease.
Orientador
 Corso di Laurea Magistrale in Biologia. Tesi di Laurea Magistrale in Basi farmacologiche della terapia. (Mestrado)
Università degli Studi del Sannio, Itália
2022/10 - Atual Autophagy dysfunction in axons: new evidence for Alzheimer´s disease pathogenesis UI/BD/154202/2022
Orientador de Emanuel Tahiri
 Doutoramento em neurociências - Experimental Biology and Biomedicine (BEB) (Doutoramento)
Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal

Universidade de Coimbra, Portugal
2024/09/01 - 2025 RNA-binding protein hnRNPH2: The role of RRM2 mutations in neuronal development and function
Orientador
 master in molecular and translational neuroscience (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
2024/09/01 - 2025 RNA-binding protein hnRNPH2: The role of NLS mutations in neuronal development and function
Orientador de Afonso Lourinho
 Master's Thesis in Cellular and Molecular Biology (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2024/03 - 2025 The Role of HNRNP H2 mutations in Epileptogenesis.
Orientador de Marco D'Ambrosio
 Tesi di Laurea Magistrale in Farmacologia Molecolare. Corso di Laurea Magistrale in Biotecnologie Genetiche e Molecolari (Mestrado)
Università degli Studi del Sannio Dipartimento di Scienze e Tecnologie, Itália
2022/09/01 - 2023/09/18 The RNA-binding protein hnRNPH2: a novel player in epileptogenesis
Orientador de Marta Sofia Santos Silva
 Biologia Celular e Molecular (Mestrado)
Universidade de Coimbra, Portugal
2022/03/01 - 2023/02/24 The role of heterogeneous ribonuclear proteins in Epilepsy and autism spectrum disorders.
Orientador de Giovanna Di Pietro
 Corso de Laurea Magistrale in Biotecnologie Genetiche e Molecolari
Università degli Studi del Sannio, Itália

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2021/10 - 2022/09 Autophagosome biogenesis and axonal transport dysfunction in Alzheimer’s disease
Orientador de Alexandra Filipa Almeida Santos
 Biologia Celular e Molecular (Mestrado)
Universidade de Coimbra, Portugal
2021/09 - 2022/09 The impact of early life stress on anxiety and depression later in life: the contribution of MeCP2
Coorientador
 Biologia Celular e Molecular (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2020/09/10 - 2021/12/13 Determine if intra-axonal mRNA translation occurs at discrete “hot spots” during synapse formation
Coorientador de Guilherme Gomes Trigo
 Biomedicina Molecular (Mestrado)
Universidade de Aveiro, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2020/09/10 - 2021/10/01 Early autophagy dysfunction in Alzheimer’s Disease: the role of WIPI2
Orientador de Emanuel Tahiri
 Biologia Celular e Molecular (Mestrado)
Università degli Studi del Sannio, Itália

Universidade de Coimbra, Portugal
2020/03/01 - 2021/02/24 Novel roles for the KCC2 co-transporter in axons: regulation of chloride homeostasis and growth cone development.
Coorientador de Giorgio Belperio
 Corso de Laurea Magistrale in Biotecnologie Genetiche e Molecolari (Mestrado)
Università degli Studi di Napoli Federico II, Itália

Università degli Studi del Sannio, Itália

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2013 - 2014/09/08 Modulation of synaptic mRNA composition
Coorientador de Helena Sofia Caria Martins
 Ribosomal regulation Axonal development (Mestrado)
Universidade de Coimbra, Portugal

Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação) 		Instituição / Organização
2024 - Atual 2024: Co-Organizer, “Well Being for Scientists II” – an initiative led by PostDoc representatives focusing on the topic of mental health within the CIBB community. December 5th-6th 2024) (2024)
2023 - Atual "Un viaggio nei meccanismi della memoria" (https://www.futuroremoto.eu/programma-completo-futuro-remoto-2023-online/) as part of the XXXVII edition of "Futuro Remoto," (https://www.futuroremoto.eu/archivio-%c2%b7-programma-edizione-2023-%c2%b7-napoli/) a science dissemination event held both in-person at Città della Scienza, Naples (Italy), and remotely. The Futuro Remoto event in 2023 received recognition from the President of the Italian Republic. (2023)
2023 - Atual “Meet My Science” (2023–2025), a seminar series initiated by PostDoc representatives at CIBB to spotlight ongoing research. (2023)
Seminário (Coorganizador)
2021/11/19 - Atual Seminar: Amyloid beta oligomers in neurodegeneration and neurodevelopment. Professor William Klein, Department of Neurobiology, Weinberg College o Arts & Sciences, Northwestern University, USA Friday, November 19, 2021, 3 pm @ Zoom Meeting Host: Rui O. Costa, CNC www.cnc.uc.pt/pt/seminars (2021/11/19)
Seminário (Coorganizador)
 Universidade de Coimbra, Portugal
2025/06/03 - 2025/06/03 2025: Co-Organizer, “Meet Our Job - Alternativas à Carreira de Investigação Científica” – An initiative led by PostDoc representatives aimed to connect students and researchers with professionals who have successfully transitioned into alternative careers outside the often-unstable realm of academic research. The event was open to the UC health sciences community (>140 participants). June 3rd, 2025. (2025)
2019 - 2022 “CNC Weekly Seminars” (2019–2022), fostering regular scientific discussions within the community. (2019 - 2023)
Seminário (Coorganizador)
2012 - 2014 Co-organizer of the Cell Physiology and Molecular Biology course lectured in the highschool “Escola secundária de Oliveira do Bairro (ESOB)” (4 courses of 10 classes, 3 hours each. Total = 120 hours). Co-author of protocol manual book used in Cell Physiology and Molecular Biology courses lectured in the highschool “Escola secundária de Oliveira do Bairro (ESOB)”. (2012 - 2014)
Outro (Coorganizador)
 Instituto de Educação e Cidadania, Portugal

Participação em evento

Descrição da atividade
Tipo de evento 		Nome do evento
Instituição / Organização
2025 - Atual HNRNP-RNDD Virtual Scientific Symposium, January 31st, 2025. Invited Speaker.
Simpósio
2024 - Atual 36th National Epileptology Meeting (ENE), Coimbra, Portugal, March 8th-9th, 2024. Received the prize of best oral presentation.
Encontro
2022/04/23 - Atual Invited speaker at the VI meet lab. O meet.Lab Coimbra é um evento organizado pelo Núcleo de Estudantes de Biologia da Associação Académica de Coimbra, com uma forte vertente de laboratório.
Encontro
 MeetLAB (VI meet.Lab; https://pt-br.facebook.com/meet.LabCoimbra/)
2022 - Atual HNRNP-Related Neurodevelopmental Disorder Scientific Symposium 2022
Simpósio
 HNRNP-Related Neurodevelopmental Disorder Scientific Symposium 2022
2015/11/19 - Atual workshops@IIIUC, intitulada: “"Grant proposals: funding opportunities and writing tips”
Oficina (workshop)
 Grant proposals: funding opportunities and writing tips
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2006 - Atual Collaborator in “Brain Awarness Week” , at the Center for Neuroscience and Cell Biology (CNC), University of Coimbra. “Brain Awarness Week”
CNC.IBILI, Portugal
2006 - Atual Collaborator in “Ciência Viva” programme, at the Center for Neuroscience and Cell Biology (CNC), University of Coimbra. “Ciência Viva” programme
CNC.IBILI, Portugal
2021/12/01 - 2021/12/03 XVII Meeting of the Portuguese Society for Neuroscience – SPN2021, Coimbra, Portugal, from 1– 3 December 2021
Encontro
 XVII Meeting of the Portuguese Society for Neuroscience – SPN2021
2021/10/04 - 2021/10/07 EMBO Workshop Axons 2021; structure and function 4-7 October 2021. Participated with the poster: Thu-PO-3-19 Intra-axonal autophagy dysfunction in Alzheimer¿s disease. Rui O. Costa, Emanuel Tahiri, Marta Silva, Carlos B. Duarte
Oficina (workshop)
 EMBO Workshop: Axons 2021: structure and function
2021/03/12 - 2021/03/13 Congresso virtual da LPCE (33º eENE)
Congresso
 Congresso virtual da LPCE (33º eENE)
2020/01/23 - 2020/01/24 The Neurobiology of Socio-Sexual Behavior (6h of Lectures). This mini symposium was organized by the Center for Neuroscience and Cell Biology and the Master Program in Cellular and Molecular Biology of the University of Coimbra.
Simpósio
 The Neurobiology of Socio-Sexual Behavior
CNC.IBILI, Portugal

Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
2016/06/17 - 2016/06/24 Workshop de Aceleração de Ideias de Negócio “Ideation Week Experience 2016 (Duration 12h).
Oficina (workshop)
 Workshop de Aceleração de Ideias de Negócio “Ideation Week Experience 2016
Instituto de Investigação Interdisciplinar da Universidade de Coimbra, Portugal
2016/06/01 - 2016/06/04 ISN 2016 meeting, Coimbra, Portugal.
Encontro
 ISN 2016 (international society for neurochemistry)
2014/11/15 - 2014/11/19 SFN 2014 meeting, Washington DC, USA.
Encontro
 SFN 2014 meeting (Society for Neuroscience)
2012 - 2014 Collaborator in activities promoted by Instituto de Educação e Cidadania (IEC) regarding Science awareness. Advanced courses in Biology for students and high school teachers - "Curso avançado de Biologia Do gene à Proteína"
Outro
 Collaborator in activities promoted by Instituto de Educação e Cidadania (IEC) regarding Science awareness
Instituto de Educação e Cidadania, Portugal
2013/05/27 - 2013/05/27 Workshop: "Grant Writing and Funding Opportunities"
Oficina (workshop)
 Workshop: "Grant Writing and Funding Opportunities"
Instituto de Investigação Interdisciplinar da Universidade de Coimbra, Portugal
2012/12/04 - 2012/12/06 Advanced fluorescence microscopy workshop. Training content: Widefield fluorescence microscopy; Confocal Microscopy (LSM 700); Strutured Ilummination Microoscopy (APOTOME); Zen imaging software. Coimbra, Portugal
Oficina (workshop)
 Advanced fluorescence microscopy workshop
CNC.IBILI, Portugal
2010/11/29 - 2010/12/03 Image processing and analysis in cell physiology. Advanced Training Workshop Department of Biology, University of Aveiro, 3810-193 Aveiro, Portugal.
Oficina (workshop)
 Image processing and analysis in cell physiology.
Universidade de Aveiro, Portugal
2010/07/03 - 2010/07/07 7th FENS, Fórum of European Neuroscience, Amsterdam, The Neatherlands.
Encontro
 7th FENS, Forum of European Neuroscience
2010/04/13 - 2010/04/13 Technical Seminar: “RNA World: not so small”. CNC, University of Coimbra, Portugal.
Seminário
 “RNA World: not so small”.
CNC.IBILI, Portugal
2010/01/11 - 2010/01/15 Gene Therapy and Nuclear Biology. Advanced course of PDBEB, CNC, University of Coimbra, Portugal. 2010, January 11th-15th.
Outro
 Gene Therapy and Nuclear Biology. Advanced course of PDBEB, CNC.
CNC.IBILI, Portugal
2009/09/02 - 2009/09/04 Course on Multifluorescence Microscopy. Training content: Confocal Microscopy (LSM 700); Strutured Ilummination Microoscopy (APOTOME). Coimbra, Portugal. 2009, September 2nd-4th.
Oficina (workshop)
 Course on Multifluorescence Microscopy
CNC.IBILI, Portugal
2009/06/25 - 2009/06/26 24a Reunião Grupo de Estudos de Envelhecimento Cerebral e Demências, Tomar, Portugal.
Encontro
 24a Reunião Grupo de Estudos de Envelhecimento Cerebral e Demências, Tomar, Portugal.
2009/03/11 - 2009/03/15 9th Internacional Conferente AD/PD, Prague, Czech Republic.
Conferência
 9th Internacional Conferente AD/PD, Prague, Czech Republic.
2008/06 - 2009/03 Course IBiS 417 - Interdepartmental Biological Sciences (IBiS) - "Structural and Cell Biology of Alzheimer's Disease" given by Doctor William L. Kein, at Northwestern University, Evanston, Chicago. 2008, September-March.
Outro
 Course IBiS 417 - Interdepartmental Biological Sciences (IBiS) - "Structural and Cell Biology of Alzheimer's Disease" lectured by Doctor William L. Kein
Northwestern University - Chicago, Estados Unidos
2008/06/26 - 2008/06/27 23a Reunião Grupo de Estudos de Envelhecimento Cerebral e Demências, Luso, Portugal.
Encontro
 23a Reunião Grupo de Estudos de Envelhecimento Cerebral e Demências, Luso, Portugal.
2008/06/12 - 2008/06/16 6th FENS, Fórum of European Neuroscience, Geneva, Switzerland.
Encontro
 6th FENS, Fórum of European Neuroscience, Geneva, Switzerland.
2008/06/06 - 2008/06/07 22a Reunião Grupo de Estudos de Envelhecimento Cerebral e Demências, Luso, Portugal.
Encontro
 22a Reunião Grupo de Estudos de Envelhecimento Cerebral e Demências, Luso, Portugal.
2007/06/08 - 2007/06/09 21a Reunião Grupo de Estudos de Envelhecimento Cerebral e Demências, Luso, Portugal.
Encontro
 21a Reunião Grupo de Estudos de Envelhecimento Cerebral e Demências, Luso, Portugal.
2007/05/25 - 2007/05/26 Meeting Portuguese Society for Neurosciences, Ofir, Portugal.
Encontro
 Meeting Portuguese Society for Neurosciences, Ofir, Portugal.
2007/01/29 - 2007/02/02 Neurogenesis and Neural Stem Cells. Advanced course of PDBEB (Doctoral program), CNC, University of Coimbra, Portugal.
Outro
 Neurogenesis and Neural Stem Cells. Advanced course of PDBEB (Doctoral program), CNC, University of Coimbra, Portugal. 2007, January 29th-February 2nd.
CNC.IBILI, Portugal
2007/01/22 - 2007/01/26 Neurodegenerative Diseases. Advanced course of PDBEB (Doctoral program), CNC, University of Coimbra, Portugal.
Outro
 Neurodegenerative Diseases. Advanced course of PDBEB (Doctoral program)
CNC.IBILI, Portugal
2007/01/15 - 2007/01/19 Cell Death and Survival Signalling. Advanced course of PDBEB (Doctoral program), CNC, University of Coimbra, Portugal.
Outro
 Cell Death and Survival Signalling. Advanced course of PDBEB (Doctoral program)
CNC.IBILI, Portugal
2007/01/08 - 2007/01/10 Biostatistics. Advanced course of PDBEB (Doctoral program), CNC, University of Coimbra, Portugal
Outro
 Biostatistics. Advanced course of PDBEB (Doctoral program)
CNC.IBILI, Portugal
2006/12/08 - 2006/12/10 XV National Congress of Biochemistry (“Congresso Nacional de Bioquímica”), Aveiro, Portugal.
Congresso
 XV National Congress of Biochemistry (“Congresso Nacional de Bioquímica”), Aveiro, Portugal.
2006/11/23 - 2006/11/24 V Congresso de Investigação em Medicina, Coimbra, Portugal.
Congresso
 V Congresso de Investigação em Medicina (Congress on Investigation in Medicine), Coimbra, Portugal.
2006/06/23 - 2006/06/24 20a Reunião Grupo de Estudos de Envelhecimento Cerebral e Demências, Tomar, Portugal.
Encontro
 20a Reunião Grupo de Estudos de Envelhecimento Cerebral e Demências, Tomar, Portugal.

Júri de grau académico

Tema
Tipo de participação 		Nome do candidato (Tipo de grau)
Instituição / Organização
2025 Catarina Catarina Pinho Neves | Dissertation: " Stress-driven alterations in cortical mitochondrial function: from cellular to early-life models" | MSc in Molecular Biomedicine, University of Aveiro. | Supervisors: Dr. Ana Cristina Carvalho Rego, Dr. Luís Manuel Souto de Miranda. | Presented to: Department of Medical Sciences, University of Aveiro. 2025
Arguente principal
 Catarina Catarina Pinho Neves (Mestrado)
Universidade de Aveiro, Portugal
2024 Catarina Filipa Guerreiro de Oliveira | Dissertation: "The role of a-synuclein in neuronal innate immunity activation: Implications to Parkinson’s disease" | MSc in Cellular and Molecular Biology (Neurobiology Specialization), University of Coimbra. | Supervisors: Professor Sandra Morais Cardoso & Professor João Peça. | Presented to: Department of Life Sciences, University of Coimbra. September 2024.
Arguente principal
 Catarina Filipa Guerreiro de Oliveira (Mestrado)
2023 Rafael de Oliveira Patarra | Dissertation: "Developing techniques to assess and optimize the efficiency of targeted protein degradation strategies for tau in the context of Alzheimer’s disease" | MSc in Cellular and Molecular Biology (Neurobiology Specialization), University of Coimbra. | Supervisor: Dr. Géraldine Gelders. Presented to: Faculty of Science and Technology, University of Coimbra. July 2023.
Arguente principal
 Rafael de Oliveira Patarra (Mestrado)
Universidade de Coimbra, Portugal
2021/12 Perturbation of endoplasmic reticulum-mitochondria crosstalk in bipolar disorder: effect of sigma-1 receptor modulation
Arguente principal
 Ana Rita Azevedo Henriques da Cunha (Mestrado)
Universidade de Coimbra, Portugal
2021/10/11 Early autophagy dysfunction in Alzheimers disease: the role of WIPI2
Orientador
 Emanuel Tahiri (Mestrado)
Universidade de Coimbra, Portugal
2021 Desenvolvimento de um hidrogel de lisados de plaquetas para indução de regeneração nervosa
Arguente principal
 Joana Filipa Ribeiro Correia (Mestrado)
Universidade de Aveiro, Portugal
2020/09/24 LAEB - Defesa de Monografia: "Development of new hydrogels for stem-cell differentiation"
Arguente principal
 Sofia Catarina Ponce Dias (Mestrado)
Universidade de Aveiro Departamento de Física, Portugal
2019/09/12 Characterization of the intracelular signalling pathways mediating the effects of purinergic receptors in dendritic and axonal formation and outgrowth
Arguente principal
 João Miguel Miranda da Rocha (Mestrado)
Universidade de Coimbra, Portugal

Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2019/09/03 Study of Tau and Synaptogyrin-3 interaction - A drug discovery approach
Arguente principal
 Ana Filipa Martins de Oliveira (Mestrado)
Hospitais da Universidade de Coimbra, Portugal

Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2018/07/27 Development of immunoassays on the Simoa platform to detect and differentiate Tau species at very low concentrations
Arguente principal
 Dina Rodrigues Martins (Mestrado)
Universidade de Coimbra, Portugal

Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2017/07/13 Assaying synaptic function using genetically -encoded optical reporters in the context of Alzheimer´s disease
Arguente principal
 Catarina Franco Quitério de Oliveira Borges (Mestrado)
Universidade de Coimbra, Portugal

Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2016/09/12 Scale for mapping the brain: the role of stargazin in regulating dendritic spine morphology
Arguente principal
 Joana de Freitas Fresco Rodrigues Costa (Mestrado)
Universidade de Coimbra, Portugal

Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2016/07/28 Apreciação do Projecto de tese: "The Role of endocytosis in BDNF-induced axonal outgrowth and branching"
Arguente principal
 Luís Filipe Maximino Martins (Doutoramento)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2015/07/13 The role of autophagy and the lysosomal pathway in the clearance of Tau aggregates
Arguente principal
 Alberto José Carpinteiro Soares (Mestrado)
Universidade de Coimbra, Portugal

Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2014/07/16 Microtubule-targeting agents: a therapeutic strategy in neurodegenerative diseases
Arguente principal
 Nuno Miguel Ferreira Morais Apóstolo (Mestrado)
Universidade de Coimbra, Portugal

Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Arbitragem científica em revista

Nome da revista (ISSN) Editora
2024 - Atual Frontiers in Cellular Neuroscience Elsivier

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2025/03/26 - Atual Cellular and Molecular Neurobiology | Neurobiology and Disease | Lecture: Neuromuscular Junction Development (March 26, 2025); Duration: 1 hour (Mestrado) Universidade de Coimbra, Portugal
2025/03/11 - Atual Cellular and Molecular Neurobiology | Lecture: Presynaptic Differentiation and Synaptogenesis (November 3, 2025) (Mestrado) Universidade de Coimbra, Portugal
2024/11/08 - Atual Cellular and Molecular Neurobiology | Lecture: Presynaptic Differentiation and Synaptogenesis (November 8, 2024); Duration: 1 hour MSc in Cellular and Molecular Biology Universidade de Coimbra, Portugal
2024/05/24 - Atual From idea to publication of results: Cell cultures and other strategies. Ciências Biomédicas (Licenciatura) Universidade do Algarve, Portugal
2024/04/05 - Atual Neurobiology and Disease Course | Neurobiology and Disease | Lecture: Neuromuscular Junction Development (April 5, 2024); Duration: 1 hour (Mestrado) Universidade de Coimbra, Portugal
2022/11/25 - Atual Lecturer at the Celular and Molecular Neurobiology of the Master in Cellular and Molecular Biology, Master in Computational biology and Master in Biochemistry at the Faculty of science and technology, University of Coimbra. 2022, November 25th. (Lecture topic: Synaptogenesis (Presynaptic differentiation and synaptogenesis). Total = 1.25 hours) (MBC, MBCM, MBIOQ, MNMT) Biologia Celular e Molecular (Mestrado integrado) Universidade de Coimbra, Portugal
2022/02/07 - Atual Lecturer at the doctoral program - PDBEB course on 'Synapse Biology', University of Coimbra. 2022, February 7th. (1 Lecture on the - Establishment of neuronal polarity and axon pathfinding, Total = 1 hours) Programa doutoral em Experimental Biology and Biomedicine (BEB) (Curso de doutoramento (conclusão de unidades curriculares)) Center for Neurosciences and Cell Biology, University of Coimbra, Portugal
2021/11/03 - Atual Lecturer at the Celular and Molecular Neurobiology of the Master in Cellular and Molecular Biology, Master in Computational biology and Master in Biochemistry at the Faculty of science and technology, University of Coimbra. 2021, November 3rd. (Lecture topic: Synaptogenesis (Presynaptic differentiation and synaptogenesis). Total = 1.4 hours) (MBC, MBCM, MBIOQ, MNMT) Biologia Celular e Molecular (Mestrado integrado) Universidade de Coimbra, Portugal
2021/03/22 - Atual Lecturer at the doctoral program - PDBEB course on 'Synapse structure and function', University of Coimbra. 2021, March 22th. (1 Lecture on the - Establishment of neuronal polarity and axon pathfinding, Total = 1 hours) Experimental Biology and Biomedicine (BEB) Center for Neurosciences and Cell Biology, University of Coimbra, Portugal
2019/04/09 - Atual Lecturer at the Neurobiology and Disease course of the Master in Cellular and Molecular Biology. Faculty of science and technology, University of Coimbra. 2019, April 9th. (Lecture on the ¿Development of the nervous system and neuronal polarity and axon pathfinding¿, Total = 3 hours) Biologia Celular e Molecular (Mestrado integrado) Universidade de Coimbra, Portugal
2014 - Atual Supervisor of laboratory rotations for students of the Master in Cell and Molecular Biology, University of Coimbra, Portugal. (Mestrado) Universidade de Coimbra, Portugal
2026/01/05 - 2026/01/09 Neuroscience Courses 2025: Synapse Function, and Plasticity | Experimental work: Study of Axonal Transport and Analysis with Kymographs (January 5-9, 2026); Duration: 25 hours Doctoral Program in Experimental Biology and Biomedicine (PDBEB) International Doctoral Program in Integrative Neuroscience (idPIN) CNC-Center for Neuroscience and Cell Biology, University of Coimbra (Curso de doutoramento (conclusão de unidades curriculares)) Universidade de Coimbra, Portugal
2024/05 - 2025/05 Neurobiology course, University of Algarve (Licenciatura) Universidade do Algarve, Portugal
2025/01/06 - 2025/01/10 Neuroscience Courses 2025: Synapse Assembly, Function, and Plasticity | Experimental work: Study of Axonal Transport and Analysis with Kymographs (January 6-10, 2025); Duration: 25 hours (Curso de doutoramento (conclusão de unidades curriculares)) Universidade de Coimbra, Portugal
2024/03/18 - 2024/03/20 Methods and Techniques in Molecular Biology (Laboratory Practices), University of Coimbra (Licenciatura) Universidade de Coimbra, Portugal
2024/01/29 - 2024/02/02 Neuroscience Courses 2024: Synapse Assembly, Function, and Plasticity | Lecture: Presynaptic Differentiation and Synaptogenesis (January 30, 2024); Duration: 1 hour | Experimental work: Study of Axonal Transport and Analysis with Kymographs (January 29-February 2, 2024); Duration: 25 hours (Curso de doutoramento (conclusão de unidades curriculares)) Universidade de Coimbra, Portugal
2023/02/27 - 2023/03/01 Lecturer at the Neurobiology course of the Biology degree at University of Coimbra, Portugal. 2023, February 27th-March 1st. Discipline: Médodos e Técnicas em Biologia Molecular (Práticas-laboratoriais) Total = 18 hours) Biologia (Licenciatura) Universidade de Coimbra, Portugal
2023/01/16 - 2023/01/20 Lecturer at the doctoral program - PDBEB course on 'Synapse assembly, function and plasticity (16-20 January 2023). 1 Lecture on the - Study of axonal transport and analysis with kymographs , Total = 1 week) programa doutoral BEB Universidade de Coimbra, Portugal
2022/12/02 - 2022/12/05 Lecturer at the Celular and Molecular Neurobiology of the Master in Cellular and Molecular Biology, Master in Computational biology and Master in Biochemistry at the Faculty of science and technology, University of Coimbra. 2022, December 2th and 5th. (Lecture topic: Synaptogenesis (Presynaptic differentiation and synaptogenesis, presentation of final works). Total = 6 hours) (MBC, MBCM, MBIOQ, MNMT) Biologia Celular e Molecular (Mestrado integrado) Universidade de Coimbra, Portugal
2022/03/28 - 2022/03/30 Lecturer at the Neurobiology course of the Biology degree at University of Coimbra, Portugal. 2022, March 28th-30th. Discipline: Médodos e Técnicas em Biologia Molecular (Práticas-laboratoriais) Total = 18 hours) Biologia (Licenciatura) Universidade de Coimbra, Portugal
2022/01/10 - 2022/01/10 Invited lecturer at the Neurobiology course of the Biochemistry degree at University of Algarve, Portugal. 2022, January 10th. (1 Lecture on neuronal development, Total = 2 hours) Bioquímica (Licenciatura) Universidade do Algarve, Portugal
2021/01/04 - 2021/01/04 Invited lecturer at the Neurobiology course of the Biochemistry degree at University of Algarve, Portugal. 2021, January 4th. (1 Lectures on neuronal development, Total = 2 hours) Bioquímica (Licenciatura) Universidade do Algarve, Portugal
2019/10/08 - 2019/10/08 Lecturer at the Cell regulation course of the Master in Cellular and Molecular Biology. Faculty of science and technology, University of Coimbra. 2019, October 8th. (Total = 2.5 hours) Biologia Celular e Molecular (Mestrado integrado) Universidade de Coimbra, Portugal
2019/03/25 - 2019/03/26 Lecturer at the Neurobiology and Disease course of the Master in Cellular and Molecular Biology. Faculty of science and technology, University of Coimbra. 2019, March 25th-26th. (4 Lectures on the “Development of the nervous system and neuronal polarity and axon pathfinding”, Total = 4.5 hours) Biologia Celular e Molecular (Mestrado) Universidade de Coimbra, Portugal
2012 - 2014 Teacher of an Experimental Science Course – Cell Physiology and Molecular Biology lectured in the highschool “Escola Secundária de Oliveira do Bairro (ESOB)”, for students of “9º ano de escolaridade”. (4 courses of 10 classes, 3 hours each. Total = 120 hours) Cell Physiology and Molecular Biology (Ensino secundário) Instituto para a Educação e a Cidadania, Portugal
2013 - 2013 Invicted lecturer. Neurosciences pratical classes integrated in the Master degree in Medicine, University of Coimbra. “Diverse Approaches To Molecular Mechanisms”. 1 lecture. Total = 3h Medicina (Mestrado integrado) Universidade de Coimbra, Portugal
2012 - 2013 Teacher in the Course "Do gene à proteína", lectured in the “Instituto para a Educação e a Cidadania (IEC), host in Mamarrosa, concelho de Oliveira do Bairro, Portugal. For highschool students. (8 classes, 3 hours each. Total = 24 hours) (Ensino secundário) Instituto para a Educação e a Cidadania, Portugal
2010 - 2010 Colaborator in Neurosciences pratical classes integrated in the Master degree in Medicine, University of Coimbra. 2010. Medicina (Mestrado integrado) Universidade de Coimbra, Portugal
2007 - 2008 Supervisor of laboratory rotations for students of the Master in Cell and Molecular Biology, University of Coimbra, Portugal. Laboratory rotations for students of the Master in Cell and Molecular Biology (Mestrado) Universidade de Coimbra, Portugal
2006 - 2006 Supervisor of laboratory rotations for students of the Doctoral Programme in Experimental Biology and Biomedicine, CNC, University of Coimbra. Laboratory rotations for students of the Doctoral Programme in Experimental Biology and Biomedicine (Doutoramento) CNC.IBILI, Portugal

Entrevista (jornal / revista)

Descrição da atividade Jornal / Forum
2019/08/09 Interview related to the manuscript published in Cell Reports. Rui O Costa is the first author and co-correspounding author. Diário as Beiras
2019/08/08 Interview related to the manuscript published in Cell Reports. Rui O Costa is the first author and co-correspounding author. Público
2013/03/28 Interview related to the program "pais com ciência" sponsored by "Ciência viva", in which the program "programa de ciência experimental para o ensino básico" was inserted. The advanced courses in "Cell Physiology and Molecular Biology Course", with the main function of science awareness, were lectured by Rui Costa and Pedro Alves to 48 students and 8 high school teacher during 2 years (2013-2014) at the ESOB (high school at Oliveira do Bairro, Portugal). Diário da Bairrada

Entrevista / Programa (rádio / tv)

Programa Tema
2013/06/25 - 2013/06/25 RTP - Notícias. (The portuguese national tv channel). Interview regarding the advanced courses in Cell Physiology and Molecular Biology Course lectured by Rui O Costa and co-conceived by Rui O Costa and IEC (Instituto para a Educação e Cidadania) to high-school 48 students and 8 teachers for 2 years (2013-2014). Cell Physiology and Molecular Biology

Membro de associação

Nome da associação Tipo de participação
2023 - Atual International Society for Neurochemistry (ISN) member
2023 - Atual European Society for Neurochemistry (ESN member
2021/02 - Atual Liga Portuguesa contra a Epilepsia (LPCE) Member (Sócio)
2006 - Atual Sociedade Portuguesa de Neurosciências (Portuguese Society for Neurosciences) Member
2006 - Atual Sociedade Portuguesa de Bioquímica (Portuguese society for Biochemistry) Member

Revisão ad hoc de artigos em revista

Nome da revista (ISSN) Editora
2021/10 - Atual Aging Cell
2017 - Atual Biochimica et Biophysica Acta (BBA) - General Subjects (0304-4165) Elsevier
2017 - Atual Heliyon (2405-8440) Elsevier
2017 - Atual Oxidative Medicine and Cellular Longevity (1942-0994) Hindawi Limited
2016 - Atual Neurochemical Research (1573-6903) Springer-Verlag
2015 - Atual Data in Brief (2352-3409) Elsevier

Tutoria

Tópico Nome do aluno
2023/02 - Atual Undergraduate students tutoring. Laboratorial Rotation students ("unidade curricular Projecto (LBIOQ) ). The role of hnRNP H2 in MRXSB. Afonso Lourinho
2017 - Atual PhD student tutoring at University of Coimbra, Portugal. "The effect of mesenchymal stem cells secretome on post-injury synapse formations" Diogo Alexandre da Silva Tomé
2025 - 2025 Impact of RNA binding proteins mutations in neuronal development and function Guilherme Galvão
2025 - 2025 The cellular role of hnRNP H2 Luca Wübbenhorst
2025 - 2025 The cellular role of hnRNP H2 Gabriel Pinheiro
2024/06 - 2024/07 The role of hnRNP H2 in epilepsy. Ana Pinto
2023 - 2024 The role of hnRNP H2 in MRXSB Afonso Lourinho
2023 - 2023 The role of hnRNP H2 in HNRNPH2-related Neurodevelopmental Disorder. Gulbenkian Novos Talentos 2023 Awardee. Role: Tutor Afonso Lourinho Pereira Maranhas Alves
2021/10 - 2022/05 The role of BDNF in autophagy Carlos Avilés Granados
2022/03/01 - 2022/03/31 Undergraduate students tutoring. Laboratorial Rotation students ("unidade curricular Projecto (LBIOQ) ). Investigation of the role of BDNF in autophagy modulation of synaptic plasticity João Videira Duarte Henriques
2022/03/01 - 2022/03/31 Undergraduate students tutoring. Laboratorial Rotation students ("unidade curricular Projecto (LBIOQ) ) Investigating the impact of Aß oligomers in the axonal retrograde transport of autophagic structures by JIP1 Rafael de Oliveira Patarra
2021/02/15 - 2021/06 Undergraduate students tutoring. Laboratorial Rotation students ("unidade curricular Projecto (LBIOQ) ) Marta Sofia Santos Silva
2020/08/01 - 2020/10/31 Tutoring in summer course. Alterações nas sinápses GABAérgicas num modelo de epileptogénese in vitro. Giorgio Belperio
2020/03 - 2020/07 Undergraduate students tutoring. Laboratorial Rotation students ("unidade curricular Projecto (LBIOQ) “) Anabela Pereira Tomás
2015/09 - 2019/09 PhD student tutoring at University of Coimbra, Portugal. " Secreted molecules in neuronal development and disease". Luis Filipe Maximino Martins
2018 - 2018 Undergraduate students tutoring. Laboratorial Rotation students ("unidade curricular Projecto (LBIOQ) “) Magda Ferreira Rodrigues
2018 - 2018 Undergraduate students tutoring. Laboratorial Rotation students ("unidade curricular Projecto (LBIOQ) “) Raquel Sofia Inácio Pinto
2016 - 2016 Undergraduate students tutoring. Laboratorial Rotation students ("unidade curricular Projecto (LBIOQ) “) Diogo António Jarró Margato
2016 - 2016 Undergraduate students tutoring. Laboratorial Rotation students ("unidade curricular Projecto (LBIOQ) “) Manuel Morais Jorge Coelho
2012 - 2013 Undergraduate students tutoring. Laboratorial Rotation students ("unidade curricular Projecto (LBIOQ) " Rita Filipe de Almeida Neves
2011 - 2013 Master student tutoring at University of Coimbra, Portugal. "Role of local protein synthesis in presynaptogenesis." Luís Filipe Maximino Martins
2008 - 2009 Master student tutoring at University of Coimbra, Portugal. "Neuroprotection by leptin and grelin against amyloid-beta toxicity in hippocampal neurons. Relevance for therapeutic intervention in Alzheimer's disease." Isaura Vanessa Antunes Martins
2008/04 - 2008/08 Master student tutoring at the university of Coimbra, Portugal. "Role of Mithocondrial Dysfunction on Tau Hyperphosphorylation." Alessandro De Stefano
Distinções

Prémio

2024 Best oral communication at "Encontro nacional de epileptologia" (ENE), Coimbra, 2024
Liga Portuguesa Contra a Epilepsia, Portugal
2022 Scientific Incentive Grant 2022 -Portuguese Epilepsy foundation (LPCE)
2022 Scholarship to attend the 8th European Synapse Meeting (ESM) (2022)
2013 Postdoctoral fellowship by FCT (SFRH/BPD/84593/2012)
Fundação para a Ciência e a Tecnologia, Portugal
2007 Travel Grant to attend the 21s Bienal Meeting of the International Society for Neurochemistry
FLAD - Fundação Luso Americana Para o desenvolvimento, Portugal
2007 Travel Grant to attend the 21st Bienal Meeting of the International Society for Neurochemistry
SPB - Sociedade Portuguesa de Bioquímica, Portugal
2006 Full PhD fellowship by FCT (SFRH/BD/28403/2006)
Fundação para a Ciência e a Tecnologia, Portugal

Título

2011 PhD in Biology
Universidade de Coimbra, Portugal

Outra distinção

2025 Research grant- "Understanding RNA-Binding Protein hnRNPH2 Mutations: Implications for Synaptic Function and Neurodevelopmental Disorders." Role: Principal Investigator (PI)
Fundação para a Ciência e a Tecnologia, Portugal
2023 Elected PostDoc Representative, Centre for Innovative Biomedicine and Biotechnology (CIBB).
2019 Junior Researcher Position, CNC (Portuguese Foundation for Science and Technology – FCT DL 57/2016/CP1448/CT0009)
Fundação para a Ciência e a Tecnologia, Portugal
2013 Exploratory Research Grant, FCT – "Mechanisms Underlying Ribosomal Regulation in Axonal Development."
Fundação para a Ciência e a Tecnologia, Portugal