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Rui Miguel Oliveira da Costa (RC) graduated in Biology in 2006 and completed the PhD in Cell Biology in 2011/12/06 by the Faculty of Science and Technology of the University of Coimbra, with highest honors. Since 2019, RC works as Contracted Researcher at the Centro de Inovação em Biomedicina e Biotecnologia (CIBB), in the Neurotrophic Signaling and Synaptic (dos)function research group. In the last 5 years RC have participated in funded research projects, presented his work in national and international meetings and published 9 articles in journals and 1 book chapter (4 as first or senior author) and has 2 more articles in submission stage, denoting his successful scientific production. In total, RC published 17 articles in journals (7 as 1st or senior author) and 2 book chapters in the Neuroscience field. RC is Senior and/or first author of his most prominent original papers published in Top percentile journals (1%-10%) in the areas of Aging and Cell Biology (e.g. Aging Cell, Neurobiology of Aging, Cell Reports). His work had 962 citations (520, since 2016), an overall Cat. Norm. Cit. Impact of 1.47. RC has a cumulative IF of 67.2 (covering 15 papers; 81.3% in Q1 journals) and an h-index of 13 (source: WOS, Google Scholar). His Scientific contributions were in the areas of Medical and Health Sciences, Basic Medicine, with emphasis on Neurosciences and Natural sciences, Biological Sciences with emphasis on Cell Biology. RC participates and/or participated as Principal investigator in 1 project (work was published in Cell Reports journal as first and co-corresponding author), as PhD Student Fellow in 1 project(s), as Post-doc Fellow in 1 project(s), as Research Technician Fellow in 1 project(s) and as Researcher in 10 project(s). In his professional activities interacted with 146 collaborator(s) co-authorship of scientific papers. RC established several national and international collaborations, and acquired large scientific expertise by working at 5 different labs (Portugal, USA & Italy), in AD and axonal biology fields, mastering a wide range of methodologies (e.g. microscopy, molecular biology, neuronal cultures, cell lines, in vivo studies, in utero electroporation, MCAo and human sample processing). In Particular RC had advanced training at one of the most respected labs in AD field (Klein's Lab), at Northwestern Univ. (USA) and at the lab of L. Cancedda (Italy). RC completed a FELASA cat C course in Laboratory Animal Science (2010). RC has Organized 1 event (conceived and lectured science courses and I has been involved in outreach science awareness activities); Participated in 29 event(s); Lectured in BSc, MSc and PhD programs at the Universities of Coimbra and Algarve and formally supervised/co-supervised 4 MSc students (Portuguese and foreign) and several undergraduate students. Mentored/ tutored several PhD and MSc students during their laboratory internships (>13 in total); Has been Committee member in several theses defenses (8 MSc thesis, as main opponent) at the University of Coimbra and University of Aveiro; Has received 5 awards and/or honors, including a PhD fellowship and Post-Doctoral fellowship in a highly competitive program (FCT 2006 and 2013, respectively); RC is ad hoc reviewer for several scientific journals. In 2017, RC benefited from paternity leave. In his curriculum Ciência Vitae the most frequent terms in the context of scientific, technological and artistic-cultural output are: Doença de Alzheimer; Peptídeo beta-amilóide; Alzheimer's disease; ER Stress; Mitochondria; NMDA receptors; Cell Culture; Cell Biology; Axonal development; Basic biology; Synaptogenesis; Neuronal development; Axonal degeneration; Synapse; Axonal growth; Ribosomes; Ubiquitin protein Synthesis; axonal biology;
Identificação

Identificação pessoal

Nome completo
Rui Miguel Oliveira da Costa
Data de nascimento
1983/06/17
Género
Masculino

Nomes de citação

  • Costa RO
  • Rui O Costa
  • Costa, Rui

Identificadores de autor

Ciência ID
8D18-658D-0961
ORCID iD
0000-0002-2652-7500
Google Scholar ID
gJoLzOwAAAAJ
Researcher Id
K-6898-2013
Scopus Author Id
36486010000

Endereços de correio eletrónico

  • ruiocosta@gmail.com (Profissional)
  • rui.costa@cnc.uc.pt (Profissional)

Telefones

Telefone
  • (+351) 239820190 (Profissional)
  • (+351) 304502914 (Profissional)
Telemóvel
  • (+351) 965138876 (Pessoal)

Moradas

  • Centro de NeuroCiências e Biologia Celular. Rua Larga, Faculdade de Medicina, Polo I, 2ºpiso, Lab 206a, Universidade de Coimbra, 3004-504, Coimbra, Coimbra, Portugal (Profissional)
  • Rua Do Brasil Nº351 2ºDir, 3030-175, Coimbra, Coimbra, Portugal (Pessoal)

Websites

  • http://www.cnbc.pt/research/department_group_show.asp?iddep=1107&idgrp=1110#34 (Profissional)

Domínios de atuação

  • Ciências Médicas e da Saúde - Medicina Básica - Neurociências
  • Ciências Naturais - Ciências Biológicas - Biologia Celular

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Inglês Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Italiano Utilizador independente (B2) Utilizador independente (B2) Utilizador elementar (A1) Utilizador proficiente (C1) Utilizador independente (B2)
Francês Utilizador independente (B1) Utilizador independente (B2) Utilizador elementar (A1) Utilizador independente (B2) Utilizador elementar (A2)
Espanhol; Castelhano Utilizador elementar (A1) Utilizador independente (B2) Utilizador elementar (A1) Utilizador independente (B2) Utilizador elementar (A2)
Japonês Utilizador elementar (A1) Utilizador elementar (A1) Utilizador elementar (A1) Utilizador elementar (A1) Utilizador elementar (A1)
Formação
Grau Classificação
2006/10/01 - 2011/12/06
Concluído
Doutoramento em Biologia - especialidade em Biologia Celular (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Endoplasmic reticulum stress during amyloid ß peptide-induced cell death: role of mitochondria and glutamatergic N-methyl-D-aspartate receptors" (TESE/DISSERTAÇÃO)
Aprovado com Distinção e Louvor, por Unanimidade.
2010/04/19 - 2010/04/30
Concluído
Course on Laboratorial Animal Science (LAS) course - FELASA cat C (Pós-Graduação)
CNC.IBILI, Portugal
Approved
2001/09 - 2006/07/05
Concluído
Biologia (Licenciatura)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Role of mitochondria in the endoplasmic reticulum-mediated apoptosis induced by the amyloid-beta peptide " (TESE/DISSERTAÇÃO)
15/20 (15.4 valores)
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento
Empregador
2019/02/05 - Atual Investigador Contratado (Investigação) Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
2013/01/01 - 2019/02/04 Pós-doutorado (Investigação) CNC.IBILI, Portugal
CNC.IBILI, Portugal
2015/09 - 2016/01 Investigador visitante (Investigação) Istituto Italiano di Tecnologia, Itália
Istituto Italiano di Tecnologia, Itália
2006/10/01 - 2011/12/06 Investigador (Investigação) CNC.IBILI, Portugal
CNC.IBILI, Portugal
2008/06 - 2009/03 Investigador visitante (Investigação) Northwestern University - Chicago, Estados Unidos
Northwestern University - Chicago, Estados Unidos

Outros

Categoria Profissional
Instituição de acolhimento
Empregador
2011/01 - 2011/09 Research Technician CNC.IBILI, Portugal
Projetos

Bolsa

Designação Financiadores
2021 - Atual Uncovering the molecular machinery responsible for cargo sorting in neuronal polarization
PTDC/BIA-CEL/2286/2020
Investigador
Fundação para a Ciência e a Tecnologia
2019 - Atual BaiTS - Biodegradable dendrimers for Targeted neuroprotective therapies in Stroke.
PTDC/CTM-NAN/3547/2014.
Investigador
2019 - Atual Strategic Plan CNC.IBILI
UID/ NEU/04539/2019
Investigador
Center for Neurosciences and Cell Biology, University of Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
2013 - 2019/02 Pos-Doc project: Mechanisms underlying ribosomal regulation in axonal development
SFRH/BPD/84593/2012
Bolseiro de Pós-Doutoramento
CNC.IBILI, Portugal
Fundação para a Ciência e a Tecnologia
2013 - 2014/12 Mechanism underlying ribosomal regulation in axonal development
grant.Provided by PTCRIS: 126236
EXPL/NEU-NMC/0541/2012
Investigador responsável
Center for Neurosciences and Cell Biology, University of Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
2010 - 2013/06 In vivo dynamics of nitric oxide in the brain: regulation of cellular respiration and implications for Alzheimer´s disease and aging
grant.Provided by PTCRIS: 103538
Investigador
Center for Neurosciences and Cell Biology, University of Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
2011 - 2011/09/30 The role of mRNA translation in the formation of the neuromuscular junction.
PTDC/SAU-NEU/104100/2008
Bolseiro de Técnico de Investigação
Center for Neurosciences and Cell Biology, University of Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
2008 - 2010 Early Diagnosis of Alzheimer’s Disease: evaluation of recent classification criteria and proposal of new diagnostic tools
PIC/IC/83206/2007
Investigador
Fundação para a Ciência e a Tecnologia
2008 - 2010 Contribution of N-methyl-D-aspartate receptor subunits to neuronal dysfunction in Alzheimer’s disease
PTDC/SAU-NEU/71675/2006
Investigador
Fundação para a Ciência e a Tecnologia
2006 - 2010 PhD project: Endoplasmic reticulum stress during amyloid ß peptide-induced cell death: role of mitochondria and glutamatergic N-methyl-D-aspartate receptors
SFRH/BD/28403/2006
Bolseiro de Doutoramento
CNC.IBILI, Portugal
Fundação para a Ciência e a Tecnologia

Projeto

Designação Financiadores
2015 - 2018 Funding of RD Units Strategic Plan - 2013/2015 - OE
UID/NEU/04539/2013
Investigador
Center for Neurosciences and Cell Biology, University of Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
2013 - 2014 Concurso para Financiamento de Projectos de IC&DT Estratégicos e de Interesse Público promovidos por Laboratórios Associados e Unidades de I&D - 2013 - COMPETE
PEst-C/SAU/LA0001/2013
Investigador
Center for Neurosciences and Cell Biology, University of Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
2009 - 2011/02 Phosphorylation and oxidation of NMDA receptor subunits in Alzheimer’s disease and protective role of memantine
n/a
Investigador
Lundbeck foundation (portuguese office)

Outro

Designação Financiadores
2005 - 2006 Cross-talk between mitochondria and endoplasmic reticulum in Alzheimer’s disease. Studies with cybrids
n/a
Investigador
Center for Neurosciences and Cell Biology, University of Coimbra, Portugal
L’Oréal Portugal/UNESCO/FCT
Produções

Publicações

Artigo em conferência
  1. Ferreira I.L.; Mota S.I.; Costa RO; Padovano C.; Fonseca A.C.; Letra L.; Oliveira C.R.; et al. "Injury markers in peripheral blood mononuclear cells from mild cognitive impairment and Alzheimer’s disease patients". Trabalho apresentado em AD/PD 2011, Barcelona, 2011.
    Publicado
  2. Costa RO; P.N. Lacor; I.L. Ferreira; A.C. Rego; W.L. Klein; C. Pereira. "Role of N-Methyl-D- Aspartate receptors in endoplasmic reticulum stress induced by amyloide peptide oligomers". Trabalho apresentado em AD/PD 2009, Prague, 2009.
    Publicado
  3. Elisabete Ferreiro; Rosa Resende; Costa RO; P Moreira; Sandra Cardoso; Cláudia Pereira; CR Oliveira. "Neurodegeneration in Alzheimer's disease: Inter-organelle cross-talk and oxidative stress in cell life and death decisions". Trabalho apresentado em European Meeting of the Society-for-Free-Radical-Research-Europe, 2007.
    Publicado
Artigo em revista
  1. Costa RO; Luís Filipe Maximino Martins; Tahiri, Emanuel; Carlos Jorge Alves Miranda Bandeira Duarte. "BDNF-induced regulation of RNA metabolism in neuronal development and synaptic plasticity". WIREs RNA (2022):
    Acesso aberto • Aceite para publicação
  2. Costa, Filipa J.; Dias, Marta S.; Costa, Rui O.; Pedro, Joana R.; Almeida, Ramiro D.. "Isolation and Culture of Chick Ciliary Ganglion Neurons". Journal of Visualized Experiments 162 (2020): http://dx.doi.org/10.3791/61431.
    10.3791/61431
  3. Costa, Rui O.; Martins, Helena; Martins, Luís F.; Cwetsch, Andrzej W.; Mele, Miranda; Pedro, Joana R.; Tomé, Diogo; et al. "Synaptogenesis Stimulates a Proteasome-Mediated Ribosome Reduction in Axons". Cell Reports 28 4 (2019): 864-876.e6. http://dx.doi.org/10.1016/j.celrep.2019.06.080.
    10.1016/j.celrep.2019.06.080
  4. Mele, Miranda; Costa, Rui O.; Duarte, Carlos B.. "Alterations in GABAA-Receptor Trafficking and Synaptic Dysfunction in Brain Disorders". Frontiers in Cellular Neuroscience 13 (2019): http://dx.doi.org/10.3389/fncel.2019.00077.
    10.3389/fncel.2019.00077
  5. Salazar, Ivan; Mele, Miranda; Caldeira, Margarida; Costa, Rui; Correia, Bárbara; Frisari, Simone; Duarte, Carlos; Costa RO. "Preparation of Primary Cultures of Embryonic Rat Hippocampal and Cerebrocortical Neurons". BIO-PROTOCOL 7 18 (2017): http://dx.doi.org/10.21769/bioprotoc.2551.
    10.21769/bioprotoc.2551
  6. Martins, L.F.; Costa, R.O.; Pedro, J.R.; Aguiar, P.; Serra, S.C.; Teixeira, F.G.; Sousa, N.; Salgado, A.J.; Almeida, R.D.. "Mesenchymal stem cells secretome-induced axonal outgrowth is mediated by BDNF". Scientific Reports 7 1 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85021292472&partnerID=MN8TOARS.
    10.1038/s41598-017-03592-1
  7. Costa, R.O.; Perestrelo, T.; Almeida, R.D.. "PROneurotrophins and CONSequences". Molecular Neurobiology (2017): 1-18. http://www.scopus.com/inward/record.url?eid=2-s2.0-85018273843&partnerID=MN8TOARS.
    10.1007/s12035-017-0505-7
  8. Graciano Leal; Diogo Comprido; Pasqualino de Luca; Eduardo Morais; Luís Rodrigues; Miranda Mele; Ana R. Santos; et al. "The RNA-Binding Protein hnRNP K Mediates the Effect of BDNF on Dendritic mRNA Metabolism and Regulates Synaptic NMDA Receptors in Hippocampal Neurons". eneuro 4 6 (2017): ENEURO.0268-17.2017. https://doi.org/10.1523/ENEURO.0268-17.2017.
    10.1523/ENEURO.0268-17.2017
  9. Pinto, M.J.; Pedro, J.R.; Costa, R.O.; Almeida, R.D.. "Visualizing K48 ubiquitination during presynaptic formation by ubiquitination-induced fluorescence complementation (UiFC)". Frontiers in Molecular Neuroscience 9 JUNE (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84978476683&partnerID=MN8TOARS.
    10.3389/fnmol.2016.00043
  10. Costa, R.O.; Mota, S.I.; Ferreira, I.L.; Santana, I.; Caldeira, G.L.; Padovano, C.; Fonseca, A.C.; et al. "Oxidative stress involving changes in Nrf2 and ER stress in early stages of Alzheimer's disease". Biochimica et Biophysica Acta - Molecular Basis of Disease 1852 7 (2015): 1428-1441. http://www.scopus.com/inward/record.url?eid=2-s2.0-84928128412&partnerID=MN8TOARS.
    10.1016/j.bbadis.2015.03.015
  11. Martins, I.; Gomes, S.; Costa, R.O.; Otvos, L.; Oliveira, C.R.; Resende, R.; Pereira, C.M.F.. "Leptin and ghrelin prevent hippocampal dysfunction induced by Aß oligomers". Neuroscience 241 (2013): 41-51. http://www.scopus.com/inward/record.url?eid=2-s2.0-84876430099&partnerID=MN8TOARS.
    10.1016/j.neuroscience.2013.02.062
  12. Costa, R.O.; Ferreiro, E.; Oliveira, C.R.; Pereira, C.M.F.. "Inhibition of mitochondrial cytochrome c oxidase potentiates Aß-induced ER stress and cell death in cortical neurons". Molecular and Cellular Neuroscience 52 (2013): 1-8. http://www.scopus.com/inward/record.url?eid=2-s2.0-84870349573&partnerID=MN8TOARS.
    10.1016/j.mcn.2012.09.005
  13. Ferreiro, E.; Baldeiras, I.; Ferreira, I.L.; Costa, R.O.; Rego, A.C.; Pereira, C.F.; Oliveira, C.R.. "Mitochondrial- and endoplasmic reticulum-associated oxidative stress in alzheimers disease: From pathogenesis to biomarkers". International Journal of Cell Biology (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84863688106&partnerID=MN8TOARS.
    10.1155/2012/735206
  14. Costa, R.O.; Ferreiro, E.; Martins, I.; Santana, I.; Cardoso, S.M.; Oliveira, C.R.; Pereira, C.M.F.. "Amyloid ß-induced ER stress is enhanced under mitochondrial dysfunction conditions". Neurobiology of Aging 33 4 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84856951448&partnerID=MN8TOARS.
    10.1016/j.neurobiolaging.2011.04.011
  15. Costa, R.O.; Lacor, P.N.; Ferreira, I.L.; Resende, R.; Auberson, Y.P.; Klein, W.L.; Oliveira, C.R.; Rego, A.C.; Pereira, C.M.F.. "Endoplasmic reticulum stress occurs downstream of GluN2B subunit of N-methyl-d-aspartate receptor in mature hippocampal cultures treated with amyloid-ß oligomers". Aging Cell 11 5 (2012): 823-833. http://www.scopus.com/inward/record.url?eid=2-s2.0-84866452758&partnerID=MN8TOARS.
    10.1111/j.1474-9726.2012.00848.x
  16. Costa, R.O.; Ferreiro, E.; Cardoso, S.M.; Oliveira, C.R.; Pereira, C.M.F.. "ER stress-mediated apoptotic pathway induced by aß peptide requires the presence of functional mitochondria". Journal of Alzheimer's Disease 20 2 (2010): 625-636. http://www.scopus.com/inward/record.url?eid=2-s2.0-77954516455&partnerID=MN8TOARS.
    10.3233/JAD-2010-091369
  17. Ferreiro, E.; Costa, R.; Marques, S.; Cardoso, S.M.; Oliveira, C.R.; Pereira, C.M.F.. "Involvement of mitochondria in endoplasmic reticulum stress-induced apoptotic cell death pathway triggered by the prion peptide PrP 106-126". Journal of Neurochemistry 104 3 (2008): 766-776. http://www.scopus.com/inward/record.url?eid=2-s2.0-38049162500&partnerID=MN8TOARS.
    10.1111/j.1471-4159.2007.05048.x
  18. Ferreiro, E.; Resende, R.; Costa, R.; Oliveira, C.R.; Pereira, C.M.F.. "An endoplasmic-reticulum-specific apoptotic pathway is involved in prion and amyloid-beta peptides neurotoxicity". Neurobiology of Disease 23 3 (2006): 669-678. http://www.scopus.com/inward/record.url?eid=2-s2.0-33747195017&partnerID=MN8TOARS.
    10.1016/j.nbd.2006.05.011
Capítulo de livro
  1. Costa, Rui O.; Perestrelo, Tânia; Tomé, Diogo; Almeida, Ramiro D.. "A Microfluidic Culture Platform for Neurotrophin Signaling Studies". In Brain-Derived Neurotrophic Factor (BDNF), 185-201. Springer New York, 2018.
    Publicado • 10.1007/7657_2018_9
  2. Elisabete Ferreiro; Costa RO; Sueli Marques; Catarina Resende de oliveira; Pereira, Cláudia Maria Pereira. "ROLE OF ENDOPLASMIC RETICULUM-MEDIATED APOPTOTIC PATHWAY IN Ab TOXICITY". In Cognitive Sciences at the leading Edge, 67-82. NY, Estados Unidos: Nova Science Publishers, Inc.,, 2008.
    Publicado
Poster em conferência
  1. Tahiri, Emanuel; Alexandra Santos; Duarte, Carlos B.; Costa RO. Autor correspondente: Costa RO. "Intra-axonal autophagy dysfunction: an early event in Alzheimers disease". Trabalho apresentado em XVII Meeting of the Portuguese Society for Neuroscience ¿ SPN2021 #NNR-71, 2021.
  2. Costa RO; Tomé, Diogo; Martins, Luís; Lia G Carvalhais; Sofia C Serra; Paulo S Pinheiro; Duarte, Carlos B.; Antonio J Salgado; Almeida, Ramiro D. "Synaptogenic effect of human umbilical cord perivascular cells secretome in central nervous system". Trabalho apresentado em XVII Meeting of the Portuguese Society for Neuroscience – SPN2021, 2021.
  3. Guilherme G Trigo; Joana R Pedro; Diogo Tomé; Costa RO; Ramiro D Almeida. "Intra-axonal mRNA translation occurs at discrete “hot spots” during synapse formation". 2021.
  4. Filipe Valente Duarte; Belperio, Giorgio; Cinzia Miarelli; Giovanna Lombardi; Duarte, Carlos B.; Costa RO; Mele, Miranda. "Activation of K+-Cl--cotransporter (KCC2) as a novel therapeutic approach for epilepsy". Trabalho apresentado em XVII Meeting of the Portuguese Society for Neuroscience – SPN2021, 2021.
  5. Costa RO; Tahiri, Emanuel; Marta Silva; Duarte, Carlos B.. Autor correspondente: Costa RO. "Intra-axonal autophagy dysfunction in Alzheimer’s disease". Trabalho apresentado em EMBO Workshop Axons 2021; structure and function, 2021.
  6. Miranda Mele; Cinzia Miarelli; Giorgio Belperio; Giovanna Lombardi; Filipe Valente Duarte; Costa RO; Carlos B. Duarte. "K+-Cl--cotransporter (KCC2) as a novel therapeutic strategy for epilepsy". Trabalho apresentado em Congresso Virtual da LPCE - 33º eENE, 2021.
  7. Diogo Tomé; Luís F. Martins; Costa RO; Sofia C. Serra, Nuno Sousa, António J. Salgado & Ramiro D. Almeida. "Mesenchymal stem cells secretome induces synapse formation in central nervous system neurons.". Trabalho apresentado em Secretive With]Out[ Borders meeting, Braga, Portugal, 6- 7th December, 2018., 2018.
  8. Costa RO; Helena Martins, Luís F. Martins, Joana R. Pedro, Miranda Mele, Andrzej Cwetsch, Laura Cancedda, Ramiro D.. "Mechanisms underlying ribosomal regulation in axonal development". Trabalho apresentado em ISN 2016 meeting, Coimbra, Portugal, June 1st-4th, 2016., 2016.
  9. Luís F. Martins; Costa RO; Susana Sampaio, Joana Pedro, Sofia Serra, Nuno Sousa, António Salgado, Ramiro Almeida. "Mesenchymal stromal cells secretome-induced axonal outgrowth is mediated by BDNF". Trabalho apresentado em ISN 2016 meeting, Coimbra, Portugal, June 1st-4th, 2016, 2016.
  10. Joana Pedro; Maria Joana Pinto; Costa RO; Pedro Alves, Hyun Ryu, Noo Li Jeon Samie Jaffrey & Ramiro Almeida. "Presynaptic differentiation triggered by target-derived cue is mediated by local protein synthesis". Trabalho apresentado em ISN 2016 meeting, Coimbra, Portugal, June 1st-4th, 2016, 2016.
  11. Costa RO; Joana R. Pedro, Maria Joana Pinto, Hyun R. Ryu, Noo Li Jeon, Samie R. Jaffrey & Ramiro D. Almeida. "Intra-axonal translation is required for synapse formation". Trabalho apresentado em SFN 2014 meeting, Washington DC, USA, November 15th-19th, 2014, 2014.
  12. Joana R. Pedro; Maria Joana Pinto; Costa RO; Hyunryul Ryu, Noo Li Jeon, Samie Jaffrey & Ramiro D. Almeida. "Intra-axonal translation of ß-actin is required for presynaptogenesis". Trabalho apresentado em 4th European synapse meeting, Bordeux, France August 28th-30th, 2013, 2013.
  13. Joana R. Pedro; Costa RO; Maria Joana Pinto, Hyunryul Ryu, Noo Li Jeon, Samie Jaffrey & Ramiro D. Almeida. "The role of axonal local translation in presynaptogenesis: the role of ß-actin". Trabalho apresentado em 9th FENS forum of Neuroscience, Milan, Italy, July 5th-9th, 2013, 2013.
  14. Joana R. Pedro; Costa RO; Maria Joana Pinto; Hyunryul Ryu; Noo Li Jeon; Samie Jaffrey; Ramiro D. Almeida. "The role of axonal local translation in presynaptogenesis: the role of ß-actin". Trabalho apresentado em 9th FENS forum of Neuroscience, 2013.
  15. Joana R. Pedro; Costa RO; Maria Joana Pinto, Hyunryul Ryu, Noo Li Jeon, Samie Jaffrey & Ramiro D. Almeida. "The role of axonal local translation in presynaptogenesis: the role of ß-actin". Trabalho apresentado em CNC meeting, Biocant, Cantanhede, December 19th-20th, 2012, 2012.
  16. Mota, S.I.; Costa RO; Caldeira G.L., Santana I., Padovano C., Fonseca A.C., Letra L., Oliveira C., Ferreira I.L., Perei. "Nrf2 downregulation-mediated oxidative stress and ER stress in early stages of Alzheimer’s disease". Trabalho apresentado em Neurodegenerative Diseases Meeting, Cold Spring Harbor, New York, USA, Nov 28th-Dec 1st, 2012. *equal contibution, 2012.
  17. Fonseca A.C.; Ferreira I.L.; Costa RO; Mota S.I., Padovano C., Letra L., Oliveira C.R., Santana I., Pereira C., Rego A.C. "Increased susceptibility to cell death following early peripheral endoplasmic reticulum and oxidative stress in Alzheimer’s disease patients". Trabalho apresentado em Sinal, 5th Annual Meeting on Cell Signalling, Coimbra, Portugal, April 29th-30st, 2011, 2011.
  18. Ferreira I.L.; Mota S.I.; Costa RO; Padovano C., Fonseca A.C., Letra L., Oliveira C.R., Santana I., Pereira C., Rego A.C. "Injury markers in peripheral blood mononuclear cells from mild cognitive impairment and Alzheimer’s disease patients". Trabalho apresentado em 10th International Conference AD/PD, Barcelona, Spain, March 9th-13th, 2011, 2011.
  19. Martins I.; Gomes S.; Costa RO; Martins I., Gomes S., Costa R.O., Resende R., Oliveira C.R., Pereira C.M.. "Effect of leptin and ghrelin in hippocampal neurons against Alzheimer ´s disease neurotoxins – amyloid-beta peptide". Trabalho apresentado em XVII National Congress of Biochemistry, Oporto, Portugal, December 15th-17th, 2010, 2010.
  20. Martins I.; Gomes S.; Costa RO; Resende R., Oliveira C.R., Pereira C.M.. "Ghrelin and leptin protect hippocampal neurons and hypothalamic cells against Aß-induced toxicity. Relevance for therapeutic intervention in Alzheimer ´s disease.". Trabalho apresentado em 2nd National Meeting on Medicinal Chemistry, Coimbra, Portugal, November 28th-30th 2010, 2010.
  21. Costa RO; Lacor P.N., Klein W.L., Rego A.C. and Pereira C.. "Alzheimer’s disease-associated amyloid-peptide oligomers induce endoplasmic reticulum stress through N-methyl-D- aspartate receptors in hippocampal neurons.". Trabalho apresentado em 7th FENS, Forum of European Neuroscience, Amsterdam, The Neatherlands, July 3rd-7th, 2010, 2010.
  22. Elisabete Ferreiro; Costa RO; Sandra Morais Cardoso, Catarina Resende de Oliveira e Cláudia Pereira.. "ER stress-mediated apoptotic pathway induced by Aß1-40 peptide requires the presence of functional mitochondria". Trabalho apresentado em 7th FENS, Forum of European Neuroscience, Amsterdam, The Netherlands, July 3rd-7th, 2010, 2010.
  23. Martins I.; Gomes S.; Costa RO; Resende R., Oliveira C.R., Pereira C.M. "Leptin and Ghrelin protect against Aß-induced toxicity in hippocampal and hypothalamic neurons". Trabalho apresentado em Final Annual Network Meeting, ENINET, Coimbra, Portugal, May 6th-8th, 2010, 2010.
  24. Oliveira C.R.,; Ferreira I.L.; Costa RO; Mota S.I., Bajouco M., Lacor P.N., Klein W.L., Rego A.C., Pereira C.. "Binding of amyloid-beta oligomers to NR2B subunits is associated with endoplasmic reticulum stress in hippocampal neurons". Trabalho apresentado em 39th Annual Meeting of the American Society for Neuroscience (SFN). Chicago, USA, October 17th-21th, 2009., 2009.
  25. Costa RO; Ferreira IL, Rego AC, Klein WL, Pereira C.. "Role of N-methyl-D-aspartate receptors in endoplasmic reticulum stress induced by Aß oligomers". Trabalho apresentado em 9th Internacional Conferente on Alzheimer’s and Parkinson’s Diseases (AD/PD), Prague, Czech Republic. March 11th -15th, 2009, 2009.
  26. Elisabete Ferreiro; Costa RO; Rosa Resende, Sueli Marques, Sandra Morais Cardoso, Catarina Resende de Oliveira e Cláudi. "Communication between endoplasmic reticulum and mitochondria in neuronal death induced by amyloid-beta peptide.". Trabalho apresentado em 5th International Congress on Vascular Dementia, Budapest, Hungary, November 8th-11th, 2008, 2008.
  27. Pereira C.,; Ferreiro E.; Costa RO; Resende R., Cardoso S., Oliveira C.R. "Cross-talk between endoplasmic reticulum and mitochondria in the neurotoxicity induced by Alzheimer’s disease- associated beta-amyloid peptide". Trabalho apresentado em 11th International Conference on Alzheimer’s Disease and Related Disorders. Chicago, USA, 26th-31st July, 2008, 2008.
  28. Costa RO; Elisabete Ferreiro, Catarina Resende de Oliveira e Cláudia Pereira. "Amyloid-beta-induced ER stress under conditions of mitochondrial respiratory chain inhibition.". Trabalho apresentado em 6th FENS, Forum of European Neuroscience, Geneva, Switzerland. June 12th-16th, 2008, 2008.
  29. Costa RO; Elisabete Ferreiro, Catarina Resende de Oliveira, Cláudia Pereira. "Interaction between mitochondria and endoplasmic reticulum during amyloid-beta peptide toxicity associated to Alzheimer´s disease". Trabalho apresentado em 10th Meeting of the Portuguese Society for Neurosciences, Ofir, Portugal, May 25th, 2007, 2007.
  30. Elisabete Ferreiro; Costa RO; Catarina R. Oliveira, Cláudia Pereira. "Mitochondrial dysfunction potentiates endoplasmic reticulum stress. Studies on Alzheimer’s disease cybrids.". Trabalho apresentado em 8th International Conference on Alzheimer’s and Parkinson’s Diseases (AD/PD), Salzburg, Austria, March 15th-18th, 2007, 2007.
  31. Elisabete Ferreiro; Costa RO; Catarina Resende de Oliveira, Cláudia Pereira. "Retículo endoplasmático e mitocôndria na doença de Alzheimer". Trabalho apresentado em XV National Congresss of Biochemistry, Aveiro, Portugal, December 8th-10th, 2006, 2006.
  32. Elisabete Ferreiro; Costa RO; Catarina Resende de Oliveira, Cláudia Pereira. "Mitochondria is required for ER-mediated apoptotic pathway induced by A-beta peptide". Trabalho apresentado em XV National Congresss of Biochemistry, Aveiro, Portugal, December 8th-10th, 2006, 2006.
  33. Ana Gouveia; Elisabete Ferreiro; Costa RO; Catarina Resende de Oliveira, Cláudia Pereira. "“Cross-talk” entre o retículo endoplasmático e a mitocôndria na doença de Alzheimer.". Trabalho apresentado em V Congresso de Investigação em Medicina, Coimbra, Portugal. November 23rd-24th, 2006., 2006.
  34. Elisabete Ferreiro; Costa RO; Catarina Resende de Oliveira e Cláudia Pereira. "Crosstalk between the endoplasmic reticulum and mitochondria in amyloid-beta-induced apoptotic death". Trabalho apresentado em 10th International Conference on Alzheimer’s disease and related disorders, Madrid, Spain, July 15th-20th, 2006, 2006.
Resumo em conferência
  1. Costa RO; Lacor, P.N.; Klein, W.L.; Rego AC; Cláudia Pereira. "Alzheimers disease-associated amyloide peptide oligomers induce endoplasmic reticulum stress throught N-Methyl-D- Aspartate receptors in hippocampal neurons". Trabalho apresentado em Federation of European Neuroscience Societies (2010), Amsterdam, 2010.
    Publicado
  2. Ferreiro, E.; Rui O Costa; Resende, R.; Marques, S.; Cardoso, S.; Oliveira, C.R.; Pereira, C.. "10.1016/j.jns.2009.02.158 Communication between endoplasmic reticulum and mitochondria in the neuronal death induced by amyloid-beta peptide". Trabalho apresentado em 5th International Congress on Vascular Dementia, Budapest, 2009.
    Publicado • 10.1016/j.jns.2009.02.158
  3. Pereira, Cláudia M.F.; Ferreiro, Elisabete B.; Rui O Costa; Resende, Rosa M.M.B.; Cardoso, Sandra M.; Oliveira, Catarina R.. "10.1016/j.jalz.2008.05.1011 P1-429: Cross-talk between endoplasmic reticulum and mitochondria in the neurotoxicity induced by Alzheimer's disease-associated beta-amyloid peptide". Trabalho apresentado em 11ª International conference on Alzheimer's Disease and Reletaded Disorders, Chicago, 2008.
    Publicado • 10.1016/j.jalz.2008.05.1011
  4. Costa RO; Elisabete Ferreiro; CR Oliveira; Cláudia Pereira. "Amyloid-beta-induced ER stress under conditions of mitochondrial respiratory chain inhibition". Trabalho apresentado em Federation of European Neuroscience Societies (FENS), Geneva, 2008.
    Publicado
  5. Costa RO; Elisabete Ferreiro; Catarina Resende de oliveira; Claudia pereira. "Does mitochondria impairment affect endoplasmic reticulum function during amyloid-beta toxicity?". Trabalho apresentado em 21st Biennial Meeting of the International-Society-for-Neurochemistry/38th Annual Meeting of the American-Society-for-Neurochemistry, 2007.
    Publicado
Tese / Dissertação
  1. Pereira, Cláudia Maria Fragão; Palmeira, Carlos. "Endoplasmic reticulum stress during amyloid ß peptide-induced cell death : role of mitochondria and glutamatergic N-methyl-D-aspartate receptors". Doutoramento, 2011. http://hdl.handle.net/10316/18243.
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2020/06/03 Synaptogenesis stimulates a proteasome-mediated ribosome reduction in axons Portuguese Postdoc exchange program
Instituto Gulbenkian de Ciência (ICG) - Portugal (WEBINAR, Portugal)
2017/02 Axonal regulation of ribosome content during development XLVII Reunião Anual da Sociedade Portuguesa de Farmacologia
Sociedade Portuguesa de Farmacologia (Coimbra, Portugal)
2017/02 Local application of MSCs secretome induces axonal elongation in CNS neurons XLVII Reunião Anual da Sociedade Portuguesa de Farmacologia
Sociedade Portuguesa de Farmacologia (Coimbra, Portugal)
2013/06 Oxidative and ER stress in early stages of Alzheimer’s disease 13a Reunião da Sociedade Portuguesa de Neurociências
Sociedade Portuguesa de Neurociências (Luso, Portugal)
2013/04 Excitotoxicity and oxidative stress in early stages of Alzheimer's Disease Oxidative Stress & Disease -The Metabolic-Inflammatory Axis in Brain Aging and Alzheimer's Disease Gordon Conference
Gordon Conference (Les Diablerets, Suiça)
2013/03/23 Alzheimer’s Disease: Biochemical Approaches to Molecular Mechanisms VI Encontro Nacional de Estudantes de Bioquímica
VI Encontro Nacional de Estudantes de Bioquímica (Aveiro, Portugal)
2012/06 Changes in oxidative and endoplasmic reticulum stress in human peripheral blood mononuclear cells during early stages of Alzheimer’s disease 26a Reunião Grupo de Estudos de Envelhecimento Cerebral e Demências
Grupo de Estudos de Envelhecimento Cerebral e Demências (Tomar, Portugal)
2012/03/17 Percurso académico e ciêntifico. O nosso actual trabalho laboratorial. Simpósio:Jovens cientistas no IEC
Instituto de Educação e Cidadania (IEC) (Mamarrosa, Oliveira do bairro, Portugal)
2010/06 Loss of endoplasmic reticulum calcium homeostasis in Alzheimer’s disease 24a Reunião Grupo de Estudos de Envelhecimento Cerebral e Demências
Grupo de Estudos de Envelhecimento Cerebral e Demências (Tomar, Portugal)
2010/06 Neuroprotection by leptin and ghrelin against amyloid-beta toxicity in hippocampal neurons. Relevance for therapeutic intervention in Alzheimer’s disease 24a Reunião Grupo de Estudos de Envelhecimento Cerebral e Demências
Grupo de Estudos de Envelhecimento Cerebral e Demências (Tomar, Portugal)
2010/06 Changes in NMDA receptor subunits expression in 3xTg-AD mice and human peripheral blood cells 24a Reunião Grupo de Estudos de Envelhecimento Cerebral e Demências
Grupo de Estudos de Envelhecimento Cerebral e Demências (Tomar, Portugal)
2009/06 Endoplasmic reticulum stress in hippocampal neurons induced by Alzheimer’s disease-Associated amyloid-beta oligomers. Role of NR2A and NR2B subunits of N-Methyl-D-ASpartate (NMDA) receptor 23a Reunião Grupo de Estudos de Envelhecimento Cerebral e Demências
Grupo de Estudos de Envelhecimento Cerebral e Demências (Luso, Portugal)
2008/06 O envolvimento mitocondrial na apoptose mediada pelo retículo endoplasmático na doença de Alzheimer 22a Reunião Grupo de Estudos de Envelhecimento Cerebral e Demências
Grupo de Estudos de Envelhecimento Cerebral e Demências (Luso, Portugal)
2007/06 Disfunção do retículo endoplasmático em cíbridos de doentes de Alzheimer 21a Reunião Grupo de Estudos de Envelhecimento Cerebral e Demências
Grupo de Estudos de Envelhecimento Cerebral e Demências (Luso, Portugal)
2006/12 Endoplasmic reticulum-specific apoptotic pathway induced by prion and amyloid-beta peptides. XXXVII Reunião Anual da Sociedade Portuguesa de Farmacologia e XXIV Reunião de Farmacologia Clínica
Sociedade Portuguesa de Farmacologia (Porto, Portugal)
2006/06 Role of mitochondria in the endoplasmic reticulum-mediated apoptosis induced by the amyloid-beta peptide 20a Reunião Grupo de Estudos de Envelhecimento Cerebral e Demências
Grupo de Estudos de Envelhecimento Cerebral e Demências (Tomar, Portugal)

Orientação

Título / Tema
Papel desempenhado
Curso (Tipo)
Instituição / Organização
2021/10 - Atual Autophagosome biogenesis and axonal transport dysfunction in Alzheimer’s disease
Orientador de Alexandra Filipa Almeida Santos
Biologia Celular e Molecular (Mestrado)
Universidade de Coimbra, Portugal
2020/09/10 - 2021/12/13 Determine if intra-axonal mRNA translation occurs at discrete “hot spots” during synapse formation
Coorientador de Guilherme Gomes Trigo
Biomedicina Molecular (Mestrado)
Universidade de Aveiro, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2020/09/10 - 2021/10 Early autophagy dysfunction in Alzheimer’s Disease: the role of WIPI2
Orientador de Emanuel Tahiri
Biologia Celular e Molecular (Mestrado)
Università degli Studi del Sannio, Itália

Universidade de Coimbra, Portugal
2020/03/01 - 2021/02/24 Novel roles for the KCC2 co-transporter in axons: regulation of chloride homeostasis and growth cone development.
Coorientador de Giorgio Belperio
Corso de Laurea Magistrale in Biotecnologie Genetiche e Molecolari (Mestrado)
Università degli Studi di Napoli Federico II, Itália

Università degli Studi del Sannio, Itália

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2013 - 2014/09/08 Modulation of synaptic mRNA composition
Coorientador de Helena Sofia Caria Martins
Modulation of synaptic mRNA composition (Mestrado)
Universidade de Coimbra, Portugal

Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação)
Instituição / Organização
2021/11/19 - Atual Seminar: Amyloid beta oligomers in neurodegeneration and neurodevelopment. Professor William Klein, Department of Neurobiology, Weinberg College o Arts & Sciences, Northwestern University, USA Friday, November 19, 2021, 3 pm @ Zoom Meeting Host: Rui O. Costa, CNC www.cnc.uc.pt/pt/seminars (2021/11/19)
Seminário (Coorganizador)
Universidade de Coimbra, Portugal
2012 - 2014 Co-organizer of the Cell Physiology and Molecular Biology course lectured in the highschool “Escola secundária de Oliveira do Bairro (ESOB)” (4 courses of 10 classes, 3 hours each. Total = 120 hours). Co-author of protocol manual book used in Cell Physiology and Molecular Biology courses lectured in the highschool “Escola secundária de Oliveira do Bairro (ESOB)”. (2012 - 2014)
Outro (Coorganizador)
Instituto de Educação e Cidadania, Portugal

Participação em evento

Descrição da atividade
Tipo de evento
Nome do evento
Instituição / Organização
2006 - Atual Collaborator in “Brain Awarness Week” , at the Center for Neuroscience and Cell Biology (CNC), University of Coimbra. “Brain Awarness Week”
CNC.IBILI, Portugal
2006 - Atual Collaborator in “Ciência Viva” programme, at the Center for Neuroscience and Cell Biology (CNC), University of Coimbra. “Ciência Viva” programme
CNC.IBILI, Portugal
2021/12/01 - 2021/12/03 XVII Meeting of the Portuguese Society for Neuroscience – SPN2021, Coimbra, Portugal, from 1– 3 December 2021
Encontro
XVII Meeting of the Portuguese Society for Neuroscience – SPN2021
2021/10/04 - 2021/10/07 EMBO Workshop Axons 2021; structure and function 4-7 October 2021. Participated with the poster: Thu-PO-3-19 Intra-axonal autophagy dysfunction in Alzheimer¿s disease. Rui O. Costa, Emanuel Tahiri, Marta Silva, Carlos B. Duarte
Oficina (workshop)
EMBO Workshop: Axons 2021: structure and function
2021/03/12 - 2021/03/13 Congresso virtual da LPCE (33º eENE)
Congresso
Congresso virtual da LPCE (33º eENE)
2020/01/23 - 2020/01/24 The Neurobiology of Socio-Sexual Behavior (6h of Lectures). This mini symposium was organized by the Center for Neuroscience and Cell Biology and the Master Program in Cellular and Molecular Biology of the University of Coimbra.
Simpósio
The Neurobiology of Socio-Sexual Behavior
CNC.IBILI, Portugal

Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
2016/06/17 - 2016/06/24 Workshop de Aceleração de Ideias de Negócio “Ideation Week Experience 2016 (Duration 12h).
Oficina (workshop)
Workshop de Aceleração de Ideias de Negócio “Ideation Week Experience 2016
Instituto de Investigação Interdisciplinar da Universidade de Coimbra, Portugal
2016/06/01 - 2016/06/04 ISN 2016 meeting, Coimbra, Portugal.
Encontro
ISN 2016 (international society for neurochemistry)
2014/11/15 - 2014/11/19 SFN 2014 meeting, Washington DC, USA.
Encontro
SFN 2014 meeting (Society for Neuroscience)
2012 - 2014 Collaborator in activities promoted by Instituto de Educação e Cidadania (IEC) regarding Science awareness. Advanced courses in Biology for students and high school teachers - "Curso avançado de Biologia Do gene à Proteína"
Outro
Collaborator in activities promoted by Instituto de Educação e Cidadania (IEC) regarding Science awareness
Instituto de Educação e Cidadania, Portugal
2013/05/27 - 2013/05/27 Workshop: "Grant Writing and Funding Opportunities"
Oficina (workshop)
Workshop: "Grant Writing and Funding Opportunities"
Instituto de Investigação Interdisciplinar da Universidade de Coimbra, Portugal
2012/12/04 - 2012/12/06 Advanced fluorescence microscopy workshop. Training content: Widefield fluorescence microscopy; Confocal Microscopy (LSM 700); Strutured Ilummination Microoscopy (APOTOME); Zen imaging software. Coimbra, Portugal
Oficina (workshop)
Advanced fluorescence microscopy workshop
CNC.IBILI, Portugal
2010/11/29 - 2010/12/03 Image processing and analysis in cell physiology. Advanced Training Workshop Department of Biology, University of Aveiro, 3810-193 Aveiro, Portugal.
Oficina (workshop)
Image processing and analysis in cell physiology.
Universidade de Aveiro, Portugal
2010/07/03 - 2010/07/07 7th FENS, Fórum of European Neuroscience, Amsterdam, The Neatherlands.
Encontro
7th FENS, Forum of European Neuroscience
2010/04/13 - 2010/04/13 Technical Seminar: “RNA World: not so small”. CNC, University of Coimbra, Portugal.
Seminário
“RNA World: not so small”.
CNC.IBILI, Portugal
2010/01/11 - 2010/01/15 Gene Therapy and Nuclear Biology. Advanced course of PDBEB, CNC, University of Coimbra, Portugal. 2010, January 11th-15th.
Outro
Gene Therapy and Nuclear Biology. Advanced course of PDBEB, CNC.
CNC.IBILI, Portugal
2009/09/02 - 2009/09/04 Course on Multifluorescence Microscopy. Training content: Confocal Microscopy (LSM 700); Strutured Ilummination Microoscopy (APOTOME). Coimbra, Portugal. 2009, September 2nd-4th.
Oficina (workshop)
Course on Multifluorescence Microscopy
CNC.IBILI, Portugal
2009/06/25 - 2009/06/26 24a Reunião Grupo de Estudos de Envelhecimento Cerebral e Demências, Tomar, Portugal.
Encontro
24a Reunião Grupo de Estudos de Envelhecimento Cerebral e Demências, Tomar, Portugal.
2009/03/11 - 2009/03/15 9th Internacional Conferente AD/PD, Prague, Czech Republic.
Conferência
9th Internacional Conferente AD/PD, Prague, Czech Republic.
2008/06 - 2009/03 Course IBiS 417 - Interdepartmental Biological Sciences (IBiS) - "Structural and Cell Biology of Alzheimer's Disease" given by Doctor William L. Kein, at Northwestern University, Evanston, Chicago. 2008, September-March.
Outro
Course IBiS 417 - Interdepartmental Biological Sciences (IBiS) - "Structural and Cell Biology of Alzheimer's Disease" lectured by Doctor William L. Kein
Northwestern University - Chicago, Estados Unidos
2008/06/26 - 2008/06/27 23a Reunião Grupo de Estudos de Envelhecimento Cerebral e Demências, Luso, Portugal.
Encontro
23a Reunião Grupo de Estudos de Envelhecimento Cerebral e Demências, Luso, Portugal.
2008/06/12 - 2008/06/16 6th FENS, Fórum of European Neuroscience, Geneva, Switzerland.
Encontro
6th FENS, Fórum of European Neuroscience, Geneva, Switzerland.
2008/06/06 - 2008/06/07 22a Reunião Grupo de Estudos de Envelhecimento Cerebral e Demências, Luso, Portugal.
Encontro
22a Reunião Grupo de Estudos de Envelhecimento Cerebral e Demências, Luso, Portugal.
2007/06/08 - 2007/06/09 21a Reunião Grupo de Estudos de Envelhecimento Cerebral e Demências, Luso, Portugal.
Encontro
21a Reunião Grupo de Estudos de Envelhecimento Cerebral e Demências, Luso, Portugal.
2007/05/25 - 2007/05/26 Meeting Portuguese Society for Neurosciences, Ofir, Portugal.
Encontro
Meeting Portuguese Society for Neurosciences, Ofir, Portugal.
2007/01/29 - 2007/02/02 Neurogenesis and Neural Stem Cells. Advanced course of PDBEB (Doctoral program), CNC, University of Coimbra, Portugal.
Outro
Neurogenesis and Neural Stem Cells. Advanced course of PDBEB (Doctoral program), CNC, University of Coimbra, Portugal. 2007, January 29th-February 2nd.
CNC.IBILI, Portugal
2007/01/22 - 2007/01/26 Neurodegenerative Diseases. Advanced course of PDBEB (Doctoral program), CNC, University of Coimbra, Portugal.
Outro
Neurodegenerative Diseases. Advanced course of PDBEB (Doctoral program)
CNC.IBILI, Portugal
2007/01/15 - 2007/01/19 Cell Death and Survival Signalling. Advanced course of PDBEB (Doctoral program), CNC, University of Coimbra, Portugal.
Outro
Cell Death and Survival Signalling. Advanced course of PDBEB (Doctoral program)
CNC.IBILI, Portugal
2007/01/08 - 2007/01/10 Biostatistics. Advanced course of PDBEB (Doctoral program), CNC, University of Coimbra, Portugal
Outro
Biostatistics. Advanced course of PDBEB (Doctoral program)
CNC.IBILI, Portugal
2006/12/08 - 2006/12/10 XV National Congress of Biochemistry (“Congresso Nacional de Bioquímica”), Aveiro, Portugal.
Congresso
XV National Congress of Biochemistry (“Congresso Nacional de Bioquímica”), Aveiro, Portugal.
2006/11/23 - 2006/11/24 V Congresso de Investigação em Medicina, Coimbra, Portugal.
Congresso
V Congresso de Investigação em Medicina (Congress on Investigation in Medicine), Coimbra, Portugal.
2006/06/23 - 2006/06/24 20a Reunião Grupo de Estudos de Envelhecimento Cerebral e Demências, Tomar, Portugal.
Encontro
20a Reunião Grupo de Estudos de Envelhecimento Cerebral e Demências, Tomar, Portugal.

Júri de grau académico

Tema
Tipo de participação
Nome do candidato (Tipo de grau)
Instituição / Organização
2021/12 Perturbation of endoplasmic reticulum-mitochondria crosstalk in bipolar disorder: effect of sigma-1 receptor modulation
Arguente principal
Ana Rita Azevedo Henriques da Cunha (Mestrado)
Universidade de Coimbra, Portugal
2021/10/11 Early autophagy dysfunction in Alzheimers disease: the role of WIPI2
Orientador
Emanuel Tahiri (Mestrado)
Universidade de Coimbra, Portugal
2021 Desenvolvimento de um hidrogel de lisados de plaquetas para indução de regeneração nervosa
Arguente principal
Joana Filipa Ribeiro Correia (Mestrado)
Universidade de Aveiro, Portugal
2020/09/24 LAEB - Defesa de Monografia: "Development of new hydrogels for stem-cell differentiation"
Arguente principal
Sofia Catarina Ponce Dias (Mestrado)
Universidade de Aveiro Departamento de Física, Portugal
2019/09/12 Characterization of the intracelular signalling pathways mediating the effects of purinergic receptors in dendritic and axonal formation and outgrowth
Arguente principal
João Miguel Miranda da Rocha (Mestrado)
Universidade de Coimbra, Portugal

Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2019/09/03 Study of Tau and Synaptogyrin-3 interaction - A drug discovery approach
Arguente principal
Ana Filipa Martins de Oliveira (Mestrado)
Hospitais da Universidade de Coimbra, Portugal

Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2018/07/27 Development of immunoassays on the Simoa platform to detect and differentiate Tau species at very low concentrations
Arguente principal
Dina Rodrigues Martins (Mestrado)
Universidade de Coimbra, Portugal

Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2017/07/13 Assaying synaptic function using genetically -encoded optical reporters in the context of Alzheimer´s disease
Arguente principal
Catarina Franco Quitério de Oliveira Borges (Mestrado)
Universidade de Coimbra, Portugal

Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2016/09/12 Scale for mapping the brain: the role of stargazin in regulating dendritic spine morphology
Arguente principal
Joana de Freitas Fresco Rodrigues Costa (Mestrado)
Universidade de Coimbra, Portugal

Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2016/07/28 Apreciação do Projecto de tese: "The Role of endocytosis in BDNF-induced axonal outgrowth and branching"
Arguente principal
Luís Filipe Maximino Martins (Doutoramento)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2015/07/13 The role of autophagy and the lysosomal pathway in the clearance of Tau aggregates
Arguente principal
Alberto José Carpinteiro Soares (Mestrado)
Universidade de Coimbra, Portugal

Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2014/07/16 Microtubule-targeting agents: a therapeutic strategy in neurodegenerative diseases
Arguente principal
Nuno Miguel Ferreira Morais Apóstolo (Mestrado)
Universidade de Coimbra, Portugal

Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Arbitragem científica em revista

Nome da revista (ISSN) Editora
2021/10 - Atual Aging Cell
2017 - Atual Biochimica et Biophysica Acta (BBA) - General Subjects (0304-4165) Elsevier
2017 - Atual Heliyon (2405-8440) Elsevier
2017 - Atual Oxidative Medicine and Cellular Longevity (1942-0994) Hindawi Limited
2016 - Atual Neurochemical Research (1573-6903) Springer-Verlag
2015 - Atual Data in Brief (2352-3409) Elsevier

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2021/11/03 - Atual Lecturer at the Celular and Molecular Neurobiology of the Master in Cellular and Molecular Biology. Faculty of science and technology, University of Coimbra. 2021, November 3rD. (Lecture on the Synaptogenesis (Presynaptic differentiation and synaptogenesis). Total = 1.4 hours) (MBC, MBCM, MBIOQ, MNMT) Biologia Celular e Molecular (Mestrado integrado) Universidade de Coimbra, Portugal
2019/04/09 - Atual Lecturer at the Neurobiology and Disease course of the Master in Cellular and Molecular Biology. Faculty of science and technology, University of Coimbra. 2019, April 9th. (Lecture on the ¿Development of the nervous system and neuronal polarity and axon pathfinding¿, Total = 3 hours) Biologia Celular e Molecular (Mestrado integrado) Universidade de Coimbra, Portugal
2014 - Atual Supervisor of laboratory rotations for students of the Master in Cell and Molecular Biology, University of Coimbra, Portugal. (Mestrado) Universidade de Coimbra, Portugal
2022/01/10 - 2022/01/10 Invited lecturer at the Neurobiology course of the Biochemistry degree at University of Algarve, Portugal. 2022, January 10th. (1 Lecture on neuronal development, Total = 2 hours) Bioquímica (Licenciatura) Universidade do Algarve, Portugal
2021/01/04 - 2021/01/04 Invited lecturer at the Neurobiology course of the Biochemistry degree at University of Algarve, Portugal. 2021, January 4th. (1 Lectures on neuronal development, Total = 2 hours) Bioquímica (Licenciatura) Universidade do Algarve, Portugal
2019/10/08 - 2019/10/08 Lecturer at the Cell regulation course of the Master in Cellular and Molecular Biology. Faculty of science and technology, University of Coimbra. 2019, October 8th. (Total = 2.5 hours) Biologia Celular e Molecular (Mestrado integrado) Universidade de Coimbra, Portugal
2019/03/25 - 2019/03/26 Lecturer at the Neurobiology and Disease course of the Master in Cellular and Molecular Biology. Faculty of science and technology, University of Coimbra. 2019, March 25th-26th. (4 Lectures on the “Development of the nervous system and neuronal polarity and axon pathfinding”, Total = 4.5 hours) Biologia Celular e Molecular (Mestrado) Universidade de Coimbra, Portugal
2012 - 2014 Teacher of an Experimental Science Course – Cell Physiology and Molecular Biology lectured in the highschool “Escola Secundária de Oliveira do Bairro (ESOB)”, for students of “9º ano de escolaridade”. (4 courses of 10 classes, 3 hours each. Total = 120 hours) Cell Physiology and Molecular Biology (Ensino secundário) Instituto para a Educação e a Cidadania, Portugal
2013 - 2013 Invicted lecturer. Neurosciences pratical classes integrated in the Master degree in Medicine, University of Coimbra. “Diverse Approaches To Molecular Mechanisms”. 1 lecture. Total = 3h Medicina (Mestrado integrado) Universidade de Coimbra, Portugal
2012 - 2013 Teacher in the Course "Do gene à proteína", lectured in the “Instituto para a Educação e a Cidadania (IEC), host in Mamarrosa, concelho de Oliveira do Bairro, Portugal. For highschool students. (8 classes, 3 hours each. Total = 24 hours) (Ensino secundário) Instituto para a Educação e a Cidadania, Portugal
2010 - 2010 Colaborator in Neurosciences pratical classes integrated in the Master degree in Medicine, University of Coimbra. 2010. Medicina (Mestrado integrado) Universidade de Coimbra, Portugal
2007 - 2008 Supervisor of laboratory rotations for students of the Master in Cell and Molecular Biology, University of Coimbra, Portugal. Laboratory rotations for students of the Master in Cell and Molecular Biology (Mestrado) Universidade de Coimbra, Portugal
2006 - 2006 Supervisor of laboratory rotations for students of the Doctoral Programme in Experimental Biology and Biomedicine, CNC, University of Coimbra. Laboratory rotations for students of the Doctoral Programme in Experimental Biology and Biomedicine (Doutoramento) CNC.IBILI, Portugal

Entrevista (jornal / revista)

Descrição da atividade Jornal / Forum
2019/08/09 Interview related to the manuscript published in Cell Reports. Rui O Costa is the first author and co-correspounding author. Diário as Beiras
2019/08/08 Interview related to the manuscript published in Cell Reports. Rui O Costa is the first author and co-correspounding author. Público
2013/03/28 Interview related to the program "pais com ciência" sponsored by "Ciência viva", in which the program "programa de ciência experimental para o ensino básico" was inserted. The advanced courses in "Cell Physiology and Molecular Biology Course", with the main function of science awareness, were lectured by Rui Costa and Pedro Alves to 48 students and 8 high school teacher during 2 years (2013-2014) at the ESOB (high school at Oliveira do Bairro, Portugal). Diário da Bairrada

Entrevista / Programa (rádio / tv)

Programa Tema
2013/06/25 - 2013/06/25 RTP - Notícias. (The portuguese national tv channel). Interview regarding the advanced courses in Cell Physiology and Molecular Biology Course lectured by Rui O Costa and co-conceived by Rui O Costa and IEC (Instituto para a Educação e Cidadania) to high-school 48 students and 8 teachers for 2 years (2013-2014). Cell Physiology and Molecular Biology

Membro de associação

Nome da associação Tipo de participação
2021/02 - Atual Liga Portuguesa contra a Epilepsia (LPCE) Member (Sócio)
2006 - Atual Sociedade Portuguesa de Neurosciências (Portuguese Society for Neurosciences) Member
2006 - Atual Sociedade Portuguesa de Bioquímica (Portuguese society for Biochemistry) Member

Tutoria

Tópico Nome do aluno
2017 - Atual PhD student tutoring at University of Coimbra, Portugal. "The effect of mesenchymal stem cells secretome on post-injury synapse formations" Diogo Alexandre da Silva Tomé
2021/10 - 2022/05 The role of BDNF in autophagy Carlos Avilés Granados
2021/02/15 - 2021/06 Undergraduate students tutoring. Laboratorial Rotation students ("unidade curricular Projecto (LBIOQ) “) Marta Sofia Santos Silva
2020/08/01 - 2020/10/31 Tutoring in summer course. Alterações nas sinápses GABAérgicas num modelo de epileptogénese in vitro. Giorgio Belperio
2020/03 - 2020/07 Undergraduate students tutoring. Laboratorial Rotation students ("unidade curricular Projecto (LBIOQ) “) Anabela Pereira Tomás
2015/09 - 2019/09 PhD student tutoring at University of Coimbra, Portugal. " Secreted molecules in neuronal development and disease". Luis Filipe Maximino Martins
2018 - 2018 Undergraduate students tutoring. Laboratorial Rotation students ("unidade curricular Projecto (LBIOQ) “) Magda Ferreira Rodrigues
2018 - 2018 Undergraduate students tutoring. Laboratorial Rotation students ("unidade curricular Projecto (LBIOQ) “) Raquel Sofia Inácio Pinto
2016 - 2016 Undergraduate students tutoring. Laboratorial Rotation students ("unidade curricular Projecto (LBIOQ) “) Diogo António Jarró Margato
2016 - 2016 Undergraduate students tutoring. Laboratorial Rotation students ("unidade curricular Projecto (LBIOQ) “) Manuel Morais Jorge Coelho
2012 - 2013 Undergraduate students tutoring. Laboratorial Rotation students ("unidade curricular Projecto (LBIOQ) " Rita Filipe de Almeida Neves
2011 - 2013 Master student tutoring at University of Coimbra, Portugal. "Role of local protein synthesis in presynaptogenesis." Luís Filipe Maximino Martins
2008 - 2009 Master student tutoring at University of Coimbra, Portugal. "Neuroprotection by leptin and gherkin against amyloid-beta toxicity in hippocampal neurons. Relevance for therapeutic intervention in Alzheimer's disease." Isaura Vanessa Antunes Martins
2008/04 - 2008/08 Master student tutoring at the university of Coimbra, Portugal. "Role of Mithocondrial Dysfunction on Tau Hyperphosphorylation." Alessandro De Stefano
Distinções

Prémio

2013 Postdoctoral fellowship by FCT (SFRH/BPD/84593/2012)
Fundação para a Ciência e a Tecnologia, Portugal
2007 Travel Grant to attend the 21s Bienal Meeting of the International Society for Neurochemistry
FLAD - Fundação Luso Americana Para o desenvolvimento, Portugal
2007 Travel Grant to attend the 21st Bienal Meeting of the International Society for Neurochemistry
SPB - Sociedade Portuguesa de Bioquímica, Portugal
2006 Full PhD fellowship by FCT (SFRH/BD/28403/2006)
Fundação para a Ciência e a Tecnologia, Portugal

Título

2011 PhD in Biology
Universidade de Coimbra, Portugal