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Rui Miguel Oliveira da Costa (RC) graduated in Biology in 2006 and obtained a PhD in Cell Biology on 2011/12/06 from the Faculty of Science and Technology of the University of Coimbra, with highest honors. He is currently an Invited Auxiliary Researcher at the Center for Neurosciences and Cell Biology (CNC/CIBB), University of Coimbra, starting his own subgroup RARE Biology. Over the last years, RC has demonstrated a strong and sustained scientific productivity. He has published a total of 22 PEER-REVIEWED ARTICLES in international journals (8 AS FIRST OR SENIOR AUTHOR), 2 BOOK CHAPTERS, and is author of 2 PREPRINTS currently under peer review, several of which appeared in top percentile journals (1–10%) in the fields of Cell Biology, Neuroscience, and Aging (e.g. BRAIN, CELL REPORTS, AGING CELL, WIREs RNA, NEUROBIOLOGY OF AGING). Of these publications, 8 have been published in the PAST 6 YEARS. Adding to this record, Rui has contributed to 13 publications in scientific meeting supplements and conference proceedings. His work has accumulated over 1700 citations, with a significant proportion since 2021, and he holds an h-index of 18 (Google Scholar). His main scientific contributions lie in Medical and Health Sciences, with emphasis on Neurosciences and Basic Medicine, as well as in Biological Sciences, particularly Cell and Synapse Biology, Axonal Development and Degeneration, Aging, and neurodevelopmental Disorders. RC has participated in numerous competitive research projects, acting as PRINCIPAL INVESTIGATOR IN 3 PROJECTS (including in the LAST FCT CALL - PROJECT THAT WILL SUPPORT THE WORKOF THIS APPLICATION COMPETE2030-FEDER-00676600, FCT – “Understanding RNA-Binding Protein hnRNPH2 Mutations: Implications for Synaptic Function and Neurodevelopmental Disorders”), as PhD Fellow in 1 project, Postdoctoral Fellow in 1 project, Research Technician Fellow in 1 project, and Researcher in 11 projects. His professional activities resulted in extensive national and international collaborations, with co-authorship involving more than 240 collaborators. He acquired broad INTERNATIONAL SCIENTIFIC EXPERTISE through work in five laboratories in Portugal, the USA, and Italy, including advanced training in renowned laboratories in Alzheimer’s disease and axonal biology (notably Klein’s Lab at Northwestern University – USA and the Cancedda’s lab at IIT - ITALY). He masters a wide range of methodologies, including advanced microscopy, molecular biology, neuronal cultures, cell lines, in vivo models, in utero electroporation, MCAo, and human sample processing. He also completed FELASA Category C training in Laboratory Animal Science. RC has been actively involved in academic teaching, supervision, and scientific dissemination. He has lectured in BSc, MSc, and PhD programs at the Universities of Coimbra and Algarve (>320 hours); supervised 1 PhD student, formally supervised 8 MSc dissertations and co-supervised 5, and mentored more than 13 MSc and PhD students during laboratory internships. He has served as main opponent in several MSc thesis defenses (13). He ORGANIZED 7 SCIENTIFIC EVENTS, participated in over 35 national and international meetings, and has been involved in outreach and science communication activities. His scientific excellence has been recognized with 12 AWARDS AND HONORS, including a scientific incentive grant (2022), highly competitive PhD and Postdoctoral fellowships from FCT, as well as a best oral presentation award at a national meeting (2024). RC is an ad hoc reviewer for several international scientific journals, including Aging Cell. His research keywords reflect a multidisciplinary focus on Neurodevelopment disorders, Alzheimer’s disease, ER stress, mitochondria, synaptic and axonal biology, aging and metabolism, biotechnology, advanced therapies, and molecular mechanisms of brain diseases. RC benefited from two paternity leaves (2017 and 2023).
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Identification

Personal identification

Full name
Rui Miguel Oliveira da Costa
Date of birth
1983/06/17
Gender
Male

Citation names

  • Costa RO
  • Rui O Costa
  • Costa, Rui

Author identifiers

Ciência ID
8D18-658D-0961
ORCID iD
0000-0002-2652-7500
Google Scholar ID
gJoLzOwAAAAJ
Researcher Id
K-6898-2013
Scopus Author Id
36486010000

Email addresses

  • ruiocosta@gmail.com (Professional)
  • rui.costa@cnc.uc.pt (Professional)

Telephones

Mobile phone
  • (+351) 965138876 (Personal)
Telephone
  • (+351) 239820190 (Professional)
  • (+351) 304502914 (Professional)

Addresses

  • Centro de NeuroCiências e Biologia Celular. Rua Larga, Faculdade de Medicina, Polo I, 2ºpiso, Lab 206a, Universidade de Coimbra, 3004-504, Coimbra, Coimbra, Portugal (Professional)
  • Rua Do Brasil Nº351 2ºDir, 3030-175, Coimbra, Coimbra, Portugal (Personal)

Websites

Knowledge fields

  • Medical and Health Sciences - Medical Biotechnology
  • Natural sciences - Biological Sciences - Cell Biology
  • Medical and Health Sciences - Basic Medicine - Neurosciences

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Italian Upper intermediate (B2) Upper intermediate (B2) Elementary (A2) Advanced (C1) Upper intermediate (B2)
French Intermediate (B1) Upper intermediate (B2) Elementary (A2) Upper intermediate (B2) Elementary (A2)
Japanese Elementary (A2) Elementary (A2) Elementary (A2) Elementary (A2) Elementary (A2)
Spanish; Castilian Beginner (A1) Upper intermediate (B2) Beginner (A1) Upper intermediate (B2) Elementary (A2)
Education
Degree Classification
2016/06/17 - 2016/06/24
Concluded
 Workshop de Aceleração de Ideias de Negócio “Ideation Week Experience 2016” (Outros)
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2006/10/01 - 2011/12/06
Concluded
 Doutoramento em Biologia - especialidade em Biologia Celular (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Endoplasmic reticulum stress during amyloid ß peptide-induced cell death: role of mitochondria and glutamatergic N-methyl-D-aspartate receptors" (THESIS/DISSERTATION)
 Aprovado com Distinção e Louvor, por Unanimidade.
2010/04/19 - 2010/04/30
Concluded
 Course on Laboratorial Animal Science (LAS) course - FELASA cat C (Pós-Graduação)
CNC.IBILI, Portugal
 Approved
2001/09 - 2006/07/05
Concluded
 Biologia (Licenciatura)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Role of mitochondria in the endoplasmic reticulum-mediated apoptosis induced by the amyloid-beta peptide " (THESIS/DISSERTATION)
 15/20 (15.4 valores)
Affiliation

Science

Category
Host institution 		Employer
2025/05 - Current Invited Auxiliary Researcher (Research) Center for Neurosciences and Cell Biology, University of Coimbra, Portugal
Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
2019/02/05 - 2025/01 Contracted Researcher (Research) Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
2013/01/01 - 2019/02/04 Postdoc (Research) CNC.IBILI, Portugal
CNC.IBILI, Portugal
2015/09 - 2016/01 Visiting Researcher (Research) Istituto Italiano di Tecnologia, Italy
Istituto Italiano di Tecnologia, Italy
2006/10/01 - 2011/12/06 Researcher (Research) CNC.IBILI, Portugal
CNC.IBILI, Portugal
2008/06 - 2009/03 Visiting Researcher (Research) Northwestern University - Chicago, United States
Northwestern University - Chicago, United States

Others

Category
Host institution 		Employer
2011/01 - 2011/09 Research Technician CNC.IBILI, Portugal
Projects

Grant

Designation Funders
2021/07/01 - Current Uncovering the molecular machinery responsible for cargo sorting in neuronal polarization
PTDC/BIA-CEL/2286/2020
Researcher
Fundação para a Ciência e a Tecnologia
2019/02/05 - Current BaiTS - Biodegradable dendrimers for Targeted neuroprotective therapies in Stroke.
PTDC/CTM-NAN/3547/2014.
Researcher
2019 - Current Strategic Plan CNC.IBILI
UID/ NEU/04539/2019
Researcher
Center for Neurosciences and Cell Biology, University of Coimbra, Portugal
 Fundação para a Ciência e a Tecnologia
2025/10 - 2028/09 Understanding RNA-Binding Protein hnRNPH2 Mutations: Implications for Synaptic Function and Neurodevelopmental Disorders.
COMPETE2030-FEDER-00676600
Principal investigator
Fundação para a Ciência e a Tecnologia
2022 - 2023 The RNA-binding protein hnRNPH2: a novel player in epileptogenesis
n.a
Principal investigator
Center for Neurosciences and Cell Biology, University of Coimbra, Portugal
 Liga Portuguesa Contra a Epilepsia
Ongoing
2013/01/01 - 2019/02 Pos-Doc project: Mechanisms underlying ribosomal regulation in axonal development
SFRH/BPD/84593/2012
Post-doc Fellow
CNC.IBILI, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2013/07 - 2014/12 Mechanism underlying ribosomal regulation in axonal development
grant.Provided by PTCRIS: 126236
EXPL/NEU-NMC/0541/2012
Principal investigator
Center for Neurosciences and Cell Biology, University of Coimbra, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2010/06/01 - 2013/06/30 Perfis dinâmicos do óxido nítrico no cérebro: regulação da respiração celular com implicações para a doença de Alzheimer e para o envelhecimento
PTDC/SAU-NEU/103538/2008
Researcher
Universidade de Coimbra, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2010/06 - 2013/06 In vivo dynamics of nitric oxide in the brain: regulation of cellular respiration and implications for Alzheimer´s disease and aging
grant.Provided by PTCRIS: 103538
Researcher
Center for Neurosciences and Cell Biology, University of Coimbra, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2011/01/01 - 2011/09/30 The role of mRNA translation in the formation of the neuromuscular junction.
PTDC/SAU-NEU/104100/2008
Research Technician Fellow
Center for Neurosciences and Cell Biology, University of Coimbra, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2009/03 - 2011/02 Phosphorylation and oxidation of NMDA receptor subunits in Alzheimer’s disease and protective role of memantine
n/a
Researcher
Lundbeck foundation (portuguese office)
2008 - 2010 Early Diagnosis of Alzheimer’s Disease: evaluation of recent classification criteria and proposal of new diagnostic tools
PIC/IC/83206/2007
Researcher
Fundação para a Ciência e a Tecnologia
2008 - 2010 Contribution of N-methyl-D-aspartate receptor subunits to neuronal dysfunction in Alzheimer’s disease
PTDC/SAU-NEU/71675/2006
Researcher
Fundação para a Ciência e a Tecnologia
2006 - 2010 PhD project: Endoplasmic reticulum stress during amyloid ß peptide-induced cell death: role of mitochondria and glutamatergic N-methyl-D-aspartate receptors
SFRH/BD/28403/2006
PhD Student Fellow
CNC.IBILI, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2005 - 2006 Cross-talk between mitochondria and endoplasmic reticulum in Alzheimer’s disease. Studies with cybrids
n.a.
Researcher
Center for Neurosciences and Cell Biology, University of Coimbra, Portugal
 L’Oréal Portugal/UNESCO/FCT
Concluded

Contract

Designation Funders
2021/01/01 - 2025/12/31 Centro de Inovação em Biomedicina e Biotecnologia - Laboratório Associado
LA/P/0058/2020
10.54499/LA/P/0058/2020
Universidade de Coimbra, Portugal

Universidade Nova de Lisboa ¿Laboratório de Instrumentação Engenharia Biomédica e Física da Radiação, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2021/01/01 - 2025/12/31 Center for Innovative Biomedicine and Biotechnology - Associate Laboratory
LA/P/0058/2020
Universidade de Coimbra, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2019/01/01 - 2019/12/31 CNC. IBILI
UID/NEU/04539/2019
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Coimbra, Portugal

Universidade de Coimbra Instituto de Ciências Nucleares Aplicadas à Saúde, Portugal

Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2015 - 2018 Funding of RD Units Strategic Plan - 2013/2015 - OE
UID/NEU/04539/2013
Researcher
Center for Neurosciences and Cell Biology, University of Coimbra, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2013 - 2014 Concurso para Financiamento de Projectos de IC&DT Estratégicos e de Interesse Público promovidos por Laboratórios Associados e Unidades de I&D - 2013 - COMPETE
PEst-C/SAU/LA0001/2013
Researcher
Center for Neurosciences and Cell Biology, University of Coimbra, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2011/01/01 - 2012/12/31 Strategic Project - LA 1 - 2011-2012
PEst-C/SAU/LA0001/2011
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book chapter
  1. Costa, Rui O.; Perestrelo, Tânia; Tomé, Diogo; Almeida, Ramiro D.. "A Microfluidic Culture Platform for Neurotrophin Signaling Studies". In Brain-Derived Neurotrophic Factor (BDNF), 185-201. Springer New York, 2018.
    Published • 10.1007/7657_2018_9
  2. Elisabete Ferreiro; Costa RO; Sueli Marques; Catarina Resende de oliveira; Pereira, Cláudia Maria Pereira. "ROLE OF ENDOPLASMIC RETICULUM-MEDIATED APOPTOTIC PATHWAY IN Ab TOXICITY". In Cognitive Sciences at the leading Edge, 67-82. NY, United States: Nova Science Publishers, Inc.,, 2008.
    Published
Conference abstract
  1. Costa RO. "The Role of BDNF-TrkB Signalling in the Synaptic Expression of NMDA Receptors in Pilocarpine Model of Temporal Lobe Epilepsy". Paper presented in ISN–ASN 2025 Meeting in New York City, USA, New York, 2025.
  2. Costa RO. Corresponding author: Costa RO. "Intra-axonal autophagosome biogenesis impairment in Alzheimer's disease". Paper presented in Journal of Neurochemistry. Volume 166, Page 139-139, Supplement 1, Special Issue SI, Meeting Abstract B 10-29. Accession Number WOS:001057599800316, ISSN 0022-3042, eISSN 1471-4159, 2023.
  3. Das, Gautami. "10th Alzheimer's disease/Parkinson's disease (AD/PD) Conference". 2011.
    10.5214/ANS.0972.7531.1118210
  4. Costa RO; Lacor, P.N.; Klein, W.L.; Rego AC; Cláudia Pereira. "Alzheimers disease-associated amyloide peptide oligomers induce endoplasmic reticulum stress throught N-Methyl-D- Aspartate receptors in hippocampal neurons". Paper presented in Federation of European Neuroscience Societies (2010), Amsterdam, 2010.
    Published
  5. Ferreiro, E.; Rui O Costa; Resende, R.; Marques, S.; Cardoso, S.; Oliveira, C.R.; Pereira, C.. "10.1016/j.jns.2009.02.158 Communication between endoplasmic reticulum and mitochondria in the neuronal death induced by amyloid-beta peptide". Paper presented in 5th International Congress on Vascular Dementia, Budapest, 2009.
    Published • 10.1016/j.jns.2009.02.158
  6. Pereira, Cláudia M.F.; Ferreiro, Elisabete B.; Rui O Costa; Resende, Rosa M.M.B.; Cardoso, Sandra M.; Oliveira, Catarina R.. "10.1016/j.jalz.2008.05.1011 P1-429: Cross-talk between endoplasmic reticulum and mitochondria in the neurotoxicity induced by Alzheimer's disease-associated beta-amyloid peptide". Paper presented in 11ª International conference on Alzheimer's Disease and Reletaded Disorders, Chicago, 2008.
    Published • 10.1016/j.jalz.2008.05.1011
  7. Costa RO; Elisabete Ferreiro; CR Oliveira; Cláudia Pereira. "Amyloid-beta-induced ER stress under conditions of mitochondrial respiratory chain inhibition". Paper presented in Federation of European Neuroscience Societies (FENS), Geneva, 2008.
    Published
Conference paper
  1. Mshelia, Philemon Paul; Napoli, Francesca; de Luca, Pasqualino; Costa, Rui O.; Mele, Miranda; Duarte, Carlos B.. "The Role of BDNF-TrkB Signalling in the Synaptic Expression of NMDA Receptors in Pilocarpine Model of Temporal Lobe Epilepsy". 2025.
  2. Ferreira I.L.; Mota S.I.; Costa RO; Padovano C.; Fonseca A.C.; Letra L.; Oliveira C.R.; et al. "Injury markers in peripheral blood mononuclear cells from mild cognitive impairment and Alzheimer’s disease patients". Paper presented in AD/PD 2011, Barcelona, 2011.
    Published
  3. Costa RO; P.N. Lacor; I.L. Ferreira; A.C. Rego; W.L. Klein; C. Pereira. "Role of N-Methyl-D- Aspartate receptors in endoplasmic reticulum stress induced by amyloide peptide oligomers". Paper presented in AD/PD 2009, Prague, 2009.
    Published
  4. Elisabete Ferreiro; Rosa Resende; Costa RO; P Moreira; Sandra Cardoso; Cláudia Pereira; CR Oliveira. "Neurodegeneration in Alzheimer's disease: Inter-organelle cross-talk and oxidative stress in cell life and death decisions". Paper presented in European Meeting of the Society-for-Free-Radical-Research-Europe, 2007.
    Published
  5. Costa, R.; Ferreiro, E.; Oliveira, C. R.; Pereira, C.. "Does mitochondria impairment affect endoplasmic reticulum function during amyloid-beta toxicity?". 2007.
  6. Elisabete B. Ferreiro; Costa RO; Catarina R. Oliveira; Cláudia M. Pereira. "P3–218: Crosstalk between the endoplasmic reticulum and mitochondria in amyloid–beta–induced apoptotic death". 2006.
    10.1016/J.JALZ.2006.05.1487
Conference poster
  1. Costa RO. Corresponding author: Costa RO. "Breaking the flow: how amyloid-ß disrupts axonal autophagy in early Alzheimer’s disease". Paper presented in ESN-ISN Joint Meeting, Naxos, Greece, 18-21 May 2025, 2025.
  2. Silva, Marta; Duarte, Carlos B.; Costa, Rui. "The RNA-binding protein hnRNP H2: a novel player in neurodevelopmental disorders and epileptogenesis". Paper presented in iMed Conference 15.0, 2023.
  3. Tahiri, Emanuel; Alexandra Filipa almeida Santos; Marta Sofia Santos Silva; Carlos Jorge Alves Miranda Bandeira Duarte; Costa, Rui. Corresponding author: Costa, Rui. "Intra-axonal autophagosome biogenesis impairment in Alzheimer’s disease". Paper presented in ISN-ESN 2023 Porto, Portugal, 2023.
  4. Tahiri, Emanuel; Alexandra Santos; Marta Silva; Carlos Jorge Alves Miranda Bandeira Duarte; Costa, Rui. Corresponding author: Costa, Rui. "Autophagy dysfunction in axons: a trigger for Alzheimer’s disease?". Paper presented in BEB DAY 2023 in Coimbra on the days 7th and 8th of February (https://cnc.uc.pt/en/pdbeb/beb-news/beb-day-2023-1), 2023.
  5. Claudia Corso; Giorgio Belperio; Cinzia Miarelli; Rodrigues, Catarina; Filipe Duarte; Costa, Rui; Duarte, Carlos B.; Mele, Miranda. "K+-Cl- cotransporter (KCC2) activation as a novel therapeutic strategy for epilepsy". Paper presented in 8th European Synapse Meeting, 20th-21st of October 2022. Coimbra, 2022.
  6. Tomé D; Martins LF; Costa RO; Serra SC; Duarte CB; Pinheiro PS; Salgado AJ; Almeida RD. "Regenerative and synaptogenic effect of human umbilical cord perivascular cells secretome in central nervous system neurons". Paper presented in VIII European Synapse Meeting (Coimbra, Portugal), 2022.
  7. Tahiri, Emanuel; Alexandra Santos; Duarte, Carlos B.; Costa RO. Corresponding author: Costa RO. "Intra-axonal autophagy dysfunction: an early event in Alzheimers disease". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience ¿ SPN2021 #NNR-71, 2021.
  8. Costa RO; Tomé, Diogo; Martins, Luís; Lia G Carvalhais; Sofia C Serra; Paulo S Pinheiro; Duarte, Carlos B.; Antonio J Salgado; Almeida, Ramiro D. "Synaptogenic effect of human umbilical cord perivascular cells secretome in central nervous system". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience – SPN2021, 2021.
  9. Guilherme G Trigo; Joana R Pedro; Diogo Tomé; Costa RO; Ramiro D Almeida. "Intra-axonal mRNA translation occurs at discrete “hot spots” during synapse formation". 2021.
  10. Filipe Valente Duarte; Belperio, Giorgio; Cinzia Miarelli; Giovanna Lombardi; Duarte, Carlos B.; Costa RO; Mele, Miranda. "Activation of K+-Cl--cotransporter (KCC2) as a novel therapeutic approach for epilepsy". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience – SPN2021, 2021.
  11. Tomé D; Martins LF; Carvalhais LG; Costa RO; Serra SC; Pinheiro PS; Duarte CB; Salgado AJ; Almeida RD. "Synaptogenic effect of human umbilical cord perivascular cells secretome in central nervous system neurons". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience (Coimbra, Portugal), 2021.
  12. Costa RO; Tahiri, Emanuel; Marta Silva; Duarte, Carlos B.. Corresponding author: Costa RO. "Intra-axonal autophagy dysfunction in Alzheimer’s disease". Paper presented in EMBO Workshop Axons 2021; structure and function, 2021.
  13. Miranda Mele; Cinzia Miarelli; Giorgio Belperio; Giovanna Lombardi; Filipe Valente Duarte; Costa RO; Carlos B. Duarte. "K+-Cl--cotransporter (KCC2) as a novel therapeutic strategy for epilepsy". Paper presented in Congresso Virtual da LPCE - 33º eENE, 2021.
  14. Diogo Tomé; Luís F. Martins; Costa RO; Sofia C. Serra, Nuno Sousa, António J. Salgado & Ramiro D. Almeida. "Mesenchymal stem cells secretome induces synapse formation in central nervous system neurons.". Paper presented in Secretive With]Out[ Borders meeting, Braga, Portugal, 6- 7th December, 2018., 2018.
  15. Costa RO; Helena Martins, Luís F. Martins, Joana R. Pedro, Miranda Mele, Andrzej Cwetsch, Laura Cancedda, Ramiro D.. "Mechanisms underlying ribosomal regulation in axonal development". Paper presented in ISN 2016 meeting, Coimbra, Portugal, June 1st-4th, 2016., 2016.
  16. Luís F. Martins; Costa RO; Susana Sampaio, Joana Pedro, Sofia Serra, Nuno Sousa, António Salgado, Ramiro Almeida. "Mesenchymal stromal cells secretome-induced axonal outgrowth is mediated by BDNF". Paper presented in ISN 2016 meeting, Coimbra, Portugal, June 1st-4th, 2016, 2016.
  17. Joana Pedro; Maria Joana Pinto; Costa RO; Pedro Alves, Hyun Ryu, Noo Li Jeon Samie Jaffrey & Ramiro Almeida. "Presynaptic differentiation triggered by target-derived cue is mediated by local protein synthesis". Paper presented in ISN 2016 meeting, Coimbra, Portugal, June 1st-4th, 2016, 2016.
  18. Costa RO; Joana R. Pedro, Maria Joana Pinto, Hyun R. Ryu, Noo Li Jeon, Samie R. Jaffrey & Ramiro D. Almeida. "Intra-axonal translation is required for synapse formation". Paper presented in SFN 2014 meeting, Washington DC, USA, November 15th-19th, 2014, 2014.
  19. Joana R. Pedro; Maria Joana Pinto; Costa RO; Hyunryul Ryu, Noo Li Jeon, Samie Jaffrey & Ramiro D. Almeida. "Intra-axonal translation of ß-actin is required for presynaptogenesis". Paper presented in 4th European synapse meeting, Bordeux, France August 28th-30th, 2013, 2013.
  20. Joana R. Pedro; Costa RO; Maria Joana Pinto, Hyunryul Ryu, Noo Li Jeon, Samie Jaffrey & Ramiro D. Almeida. "The role of axonal local translation in presynaptogenesis: the role of ß-actin". Paper presented in 9th FENS forum of Neuroscience, Milan, Italy, July 5th-9th, 2013, 2013.
  21. Joana R. Pedro; Costa RO; Maria Joana Pinto; Hyunryul Ryu; Noo Li Jeon; Samie Jaffrey; Ramiro D. Almeida. "The role of axonal local translation in presynaptogenesis: the role of ß-actin". Paper presented in 9th FENS forum of Neuroscience, 2013.
  22. Rego, A. Cristina; Mota, S.I.; Costa, Rui; Caldeira, Gladys Lima; Santana, Isabel; Padovano, C.; Ana Catarina RG Fonseca; et al. "Oxidative and ER stress in early stages of Alzheimer’s disease". Paper presented in XIII Reunião da Sociedade Portuguesa de Neurociências, 2013.
  23. Joana R. Pedro; Costa RO; Maria Joana Pinto, Hyunryul Ryu, Noo Li Jeon, Samie Jaffrey & Ramiro D. Almeida. "The role of axonal local translation in presynaptogenesis: the role of ß-actin.". Paper presented in CNC meeting, Biocant, Cantanhede, December 19th-20th, 2012, 2012.
  24. Mota, S.I.; Costa RO; Caldeira G.L., Santana I., Padovano C., Fonseca A.C., Letra L., Oliveira C., Ferreira I.L., Perei. "Nrf2 downregulation-mediated oxidative stress and ER stress in early stages of Alzheimer’s disease". Paper presented in Neurodegenerative Diseases Meeting, Cold Spring Harbor, New York, USA, Nov 28th-Dec 1st, 2012. *equal contibution, 2012.
  25. Mota, S.I.; Costa, Rui; Santana, Isabel; Padovano, C.; Ana Catarina RG Fonseca; Caldeira, Gladys Lima; Letra, L.; et al. "Changes in oxidative and endoplasmic reticulum stress in human peripheral blood mononuclear cells during early stages of Alzheimer’s disease". Paper presented in 26ª Reunião do Grupo de Estudos de Envelhecimento Cerebral e Demência, 2012.
  26. Fonseca A.C.; Ferreira I.L.; Costa RO; Mota S.I., Padovano C., Letra L., Oliveira C.R., Santana I., Pereira C., Rego A.C. "Increased susceptibility to cell death following early peripheral endoplasmic reticulum and oxidative stress in Alzheimer’s disease patients". Paper presented in Sinal, 5th Annual Meeting on Cell Signalling, Coimbra, Portugal, April 29th-30st, 2011, 2011.
  27. Ferreira I.L.; Mota S.I.; Costa RO; Padovano C., Fonseca A.C., Letra L., Oliveira C.R., Santana I., Pereira C., Rego A.C. "Injury markers in peripheral blood mononuclear cells from mild cognitive impairment and Alzheimer’s disease patients". Paper presented in 10th International Conference AD/PD, Barcelona, Spain, March 9th-13th, 2011, 2011.
  28. Martins I.; Gomes S.; Costa RO; Martins I., Gomes S., Costa R.O., Resende R., Oliveira C.R., Pereira C.M.. "Effect of leptin and ghrelin in hippocampal neurons against Alzheimer ´s disease neurotoxins – amyloid-beta peptide". Paper presented in XVII National Congress of Biochemistry, Oporto, Portugal, December 15th-17th, 2010, 2010.
  29. Martins, Isaura; Gomes, Sílvia; Costa, Rui; Resende, Rosa; Oliveira, Catarina R; Pereira, Cláudia Fragão. "Ghrelin and leptin protect hippocampal neurons against Aß-induced toxicity. Relevance for therapeutic intervention in Alzheimer’s disease.". Paper presented in XVII National Congress of the Portuguese Biochemical Society, 2010.
  30. Martins I.; Gomes S.; Costa RO; Resende R., Oliveira C.R., Pereira C.M.. "Ghrelin and leptin protect hippocampal neurons and hypothalamic cells against Aß-induced toxicity. Relevance for therapeutic intervention in Alzheimer ´s disease.". Paper presented in 2nd National Meeting on Medicinal Chemistry, Coimbra, Portugal, November 28th-30th 2010, 2010.
  31. Costa RO; Lacor P.N., Klein W.L., Rego A.C. and Pereira C.. "Alzheimer’s disease-associated amyloid-peptide oligomers induce endoplasmic reticulum stress through N-methyl-D- aspartate receptors in hippocampal neurons.". Paper presented in 7th FENS, Forum of European Neuroscience, Amsterdam, The Neatherlands, July 3rd-7th, 2010, 2010.
  32. Elisabete Ferreiro; Costa RO; Sandra Morais Cardoso, Catarina Resende de Oliveira e Cláudia Pereira.. "ER stress-mediated apoptotic pathway induced by Aß1-40 peptide requires the presence of functional mitochondria". Paper presented in 7th FENS, Forum of European Neuroscience, Amsterdam, The Netherlands, July 3rd-7th, 2010, 2010.
  33. Martins I.; Gomes S.; Costa RO; Resende R., Oliveira C.R., Pereira C.M. "Leptin and Ghrelin protect against Aß-induced toxicity in hippocampal and hypothalamic neurons". Paper presented in Final Annual Network Meeting, ENINET, Coimbra, Portugal, May 6th-8th, 2010, 2010.
  34. Oliveira C.R.,; Ferreira I.L.; Costa RO; Mota S.I., Bajouco M., Lacor P.N., Klein W.L., Rego A.C., Pereira C.. "Binding of amyloid-beta oligomers to NR2B subunits is associated with endoplasmic reticulum stress in hippocampal neurons". Paper presented in 39th Annual Meeting of the American Society for Neuroscience (SFN). Chicago, USA, October 17th-21th, 2009., 2009.
  35. Costa RO; Ferreira IL, Rego AC, Klein WL, Pereira C.. "Role of N-methyl-D-aspartate receptors in endoplasmic reticulum stress induced by Aß oligomers". Paper presented in 9th Internacional Conferente on Alzheimer’s and Parkinson’s Diseases (AD/PD), Prague, Czech Republic. March 11th -15th, 2009, 2009.
  36. Elisabete Ferreiro; Costa RO; Rosa Resende, Sueli Marques, Sandra Morais Cardoso, Catarina Resende de Oliveira e Cláudi. "Communication between endoplasmic reticulum and mitochondria in neuronal death induced by amyloid-beta peptide.". Paper presented in 5th International Congress on Vascular Dementia, Budapest, Hungary, November 8th-11th, 2008, 2008.
  37. Pereira C.,; Ferreiro E.; Costa RO; Resende R., Cardoso S., Oliveira C.R. "Cross-talk between endoplasmic reticulum and mitochondria in the neurotoxicity induced by Alzheimer’s disease- associated beta-amyloid peptide". Paper presented in 11th International Conference on Alzheimer’s Disease and Related Disorders. Chicago, USA, 26th-31st July, 2008, 2008.
  38. Costa RO; Elisabete Ferreiro, Catarina Resende de Oliveira e Cláudia Pereira. "Amyloid-beta-induced ER stress under conditions of mitochondrial respiratory chain inhibition.". Paper presented in 6th FENS, Forum of European Neuroscience, Geneva, Switzerland. June 12th-16th, 2008, 2008.
  39. Ferreiro, Elisabete; Rui O Costa; Rosa Resende; Sueli Marques; Sandra Morais Cardoso; Catarina Resende de Oliveira; Cláudia Maria Fragão Pereira. "Communication between endoplasmic reticulum and mitochondria in the neuronal death induced by amyloid-beta peptide". Paper presented in Fifth International Congress on Vascular Dementia, Budapest, Hungary, 2007.
  40. Costa RO; Elisabete Ferreiro, Catarina Resende de Oliveira, Cláudia Pereira. "Interaction between mitochondria and endoplasmic reticulum during amyloid-beta peptide toxicity associated to Alzheimer´s disease". Paper presented in 10th Meeting of the Portuguese Society for Neurosciences, Ofir, Portugal, May 25th, 2007, 2007.
  41. Elisabete Ferreiro; Costa RO; Catarina R. Oliveira, Cláudia Pereira. "Mitochondrial dysfunction potentiates endoplasmic reticulum stress. Studies on Alzheimer’s disease cybrids.". Paper presented in 8th International Conference on Alzheimer’s and Parkinson’s Diseases (AD/PD), Salzburg, Austria, March 15th-18th, 2007, 2007.
  42. Elisabete Ferreiro; Costa RO; Catarina Resende de Oliveira, Cláudia Pereira. "Retículo endoplasmático e mitocôndria na doença de Alzheimer". Paper presented in XV National Congresss of Biochemistry, Aveiro, Portugal, December 8th-10th, 2006, 2006.
  43. Elisabete Ferreiro; Costa RO; Catarina Resende de Oliveira, Cláudia Pereira. "Mitochondria is required for ER-mediated apoptotic pathway induced by A-beta peptide". Paper presented in XV National Congresss of Biochemistry, Aveiro, Portugal, December 8th-10th, 2006, 2006.
  44. Ana Gouveia; Elisabete Ferreiro; Costa RO; Catarina Resende de Oliveira, Cláudia Pereira. "“Cross-talk” entre o retículo endoplasmático e a mitocôndria na doença de Alzheimer.". Paper presented in V Congresso de Investigação em Medicina, Coimbra, Portugal. November 23rd-24th, 2006., 2006.
  45. Elisabete Ferreiro; Costa RO; Catarina Resende de Oliveira e Cláudia Pereira. "Crosstalk between the endoplasmic reticulum and mitochondria in amyloid-beta-induced apoptotic death". Paper presented in 10th International Conference on Alzheimer’s disease and related disorders, Madrid, Spain, July 15th-20th, 2006, 2006.
Journal article
  1. Lourinho, Afonso; Silva, Marta; Tahiri, Emanuel; Pinto, Ana; Caniceiro, Beatriz; Moreira, Irina; Duarte, Carlos B; Costa, Rui O. Corresponding author: Costa, Rui O. "RNArchitects: how hnRNPs shape neuronal landscapes". Brain (2025): https://doi.org/10.1093/brain/awaf448.
    Accepted • 10.1093/brain/awaf448
  2. De Luca, Pasqualino; Mele, Miranda; Tanqueiro, Sara; Napoli, Francesca; Butkeviciute, Ugné; Souto, Arthur C.; Costa, Rui O.; et al. "Synaptic accumulation of GluN2B-containing NMDA receptors mediates the effects of BDNF-TrkB signalling on synaptic plasticity and in hyperexcitability during status epilepticus". Journal of Biomedical Science 32 1 (2025): https://doi.org/10.1186/s12929-025-01164-4.
    10.1186/s12929-025-01164-4
  3. Tomé, Diogo; Martins, Luís F.; Aroso, Miguel; Santos, Henrique; Costa, Rui O.; Afonso, João L.; Serra, Sofia C.; et al. "Mesenchymal stromal cell secretome-induced synaptogenesis is mediated by thrombospondin-1". iScience 28 9 (2025): 113401. https://doi.org/10.1016/j.isci.2025.113401.
    10.1016/j.isci.2025.113401
  4. Salazar, Ivan L.; Curcio, Michele; Mele, Miranda; Vetrone, Rossela; Frisari, Simone; Costa, Rui O.; Caldeira, Margarida V.; Trader, Darci J.; Duarte, Carlos B.. "Activation of the 20S proteasome core particle prevents cell death induced by oxygen- and glucose deprivation in cultured cortical neurons". Apoptosis 30 5-6 (2025): 1372-1390. https://doi.org/10.1007/s10495-025-02097-x.
    10.1007/s10495-025-02097-x
  5. Rui O. Costa; Luís F. Martins; Emanuel Tahiri; Carlos B. Duarte. "Brain-derived neurotrophic factor -induced regulation of RNA metabolism in neuronal development and synaptic plasticity". WIREs RNA (2022): https://doi.org/10.1002/wrna.1713.
    10.1002/wrna.1713
  6. Costa, Filipa J.; Dias, Marta S.; Costa, Rui O.; Pedro, Joana R.; Almeida, Ramiro D.. "Isolation and Culture of Chick Ciliary Ganglion Neurons". Journal of Visualized Experiments 162 (2020): http://dx.doi.org/10.3791/61431.
    10.3791/61431
  7. Costa, Rui O.; Martins, Helena; Martins, Luís F.; Cwetsch, Andrzej W.; Mele, Miranda; Pedro, Joana R.; Tomé, Diogo; et al. "Synaptogenesis Stimulates a Proteasome-Mediated Ribosome Reduction in Axons". Cell Reports 28 4 (2019): 864-876.e6. http://dx.doi.org/10.1016/j.celrep.2019.06.080.
    10.1016/j.celrep.2019.06.080
  8. Mele, Miranda; Costa, Rui O.; Duarte, Carlos B.. "Alterations in GABAA-Receptor Trafficking and Synaptic Dysfunction in Brain Disorders". Frontiers in Cellular Neuroscience 13 (2019): http://dx.doi.org/10.3389/fncel.2019.00077.
    10.3389/fncel.2019.00077
  9. Salazar, Ivan; Mele, Miranda; Caldeira, Margarida; Costa, Rui; Correia, Bárbara; Frisari, Simone; Duarte, Carlos. Corresponding author: Duarte, Carlos. "Preparation of Primary Cultures of Embryonic Rat Hippocampal and Cerebrocortical Neurons". BIO-PROTOCOL 7 18 (2017): http://dx.doi.org/10.21769/bioprotoc.2551.
    10.21769/bioprotoc.2551
  10. Martins, L.F.; Costa, R.O.; Pedro, J.R.; Aguiar, P.; Serra, S.C.; Teixeira, F.G.; Sousa, N.; Salgado, A.J.; Almeida, R.D.. "Mesenchymal stem cells secretome-induced axonal outgrowth is mediated by BDNF". Scientific Reports 7 1 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85021292472&partnerID=MN8TOARS.
    10.1038/s41598-017-03592-1
  11. Costa, R.O.; Perestrelo, T.; Almeida, R.D.. "PROneurotrophins and CONSequences". Molecular Neurobiology (2017): 1-18. http://www.scopus.com/inward/record.url?eid=2-s2.0-85018273843&partnerID=MN8TOARS.
    10.1007/s12035-017-0505-7
  12. Graciano Leal; Diogo Comprido; Pasqualino de Luca; Eduardo Morais; Luís Rodrigues; Miranda Mele; Ana R. Santos; et al. "The RNA-Binding Protein hnRNP K Mediates the Effect of BDNF on Dendritic mRNA Metabolism and Regulates Synaptic NMDA Receptors in Hippocampal Neurons". eneuro 4 6 (2017): ENEURO.0268-17.2017. https://doi.org/10.1523/ENEURO.0268-17.2017.
    10.1523/ENEURO.0268-17.2017
  13. Pinto, M.J.; Pedro, J.R.; Costa, R.O.; Almeida, R.D.. "Visualizing K48 ubiquitination during presynaptic formation by ubiquitination-induced fluorescence complementation (UiFC)". Frontiers in Molecular Neuroscience 9 JUNE (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84978476683&partnerID=MN8TOARS.
    10.3389/fnmol.2016.00043
  14. Costa, R.O.; Mota, S.I.; Ferreira, I.L.; Santana, I.; Caldeira, G.L.; Padovano, C.; Fonseca, A.C.; et al. "Oxidative stress involving changes in Nrf2 and ER stress in early stages of Alzheimer's disease". Biochimica et Biophysica Acta - Molecular Basis of Disease 1852 7 (2015): 1428-1441. http://www.scopus.com/inward/record.url?eid=2-s2.0-84928128412&partnerID=MN8TOARS.
    10.1016/j.bbadis.2015.03.015
  15. Martins, I.; Gomes, S.; Costa, R.O.; Otvos, L.; Oliveira, C.R.; Resende, R.; Pereira, C.M.F.. "Leptin and ghrelin prevent hippocampal dysfunction induced by Aß oligomers". Neuroscience 241 (2013): 41-51. http://www.scopus.com/inward/record.url?eid=2-s2.0-84876430099&partnerID=MN8TOARS.
    10.1016/j.neuroscience.2013.02.062
  16. Costa, R.O.; Ferreiro, E.; Oliveira, C.R.; Pereira, C.M.F.. "Inhibition of mitochondrial cytochrome c oxidase potentiates Aß-induced ER stress and cell death in cortical neurons". Molecular and Cellular Neuroscience 52 (2013): 1-8. http://www.scopus.com/inward/record.url?eid=2-s2.0-84870349573&partnerID=MN8TOARS.
    10.1016/j.mcn.2012.09.005
  17. Ferreiro, E.; Baldeiras, I.; Ferreira, I.L.; Costa, R.O.; Rego, A.C.; Pereira, C.F.; Oliveira, C.R.. "Mitochondrial- and endoplasmic reticulum-associated oxidative stress in alzheimers disease: From pathogenesis to biomarkers". International Journal of Cell Biology (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84863688106&partnerID=MN8TOARS.
    10.1155/2012/735206
  18. Costa, R.O.; Ferreiro, E.; Martins, I.; Santana, I.; Cardoso, S.M.; Oliveira, C.R.; Pereira, C.M.F.. "Amyloid ß-induced ER stress is enhanced under mitochondrial dysfunction conditions". Neurobiology of Aging 33 4 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84856951448&partnerID=MN8TOARS.
    10.1016/j.neurobiolaging.2011.04.011
  19. Costa, R.O.; Lacor, P.N.; Ferreira, I.L.; Resende, R.; Auberson, Y.P.; Klein, W.L.; Oliveira, C.R.; Rego, A.C.; Pereira, C.M.F.. "Endoplasmic reticulum stress occurs downstream of GluN2B subunit of N-methyl-d-aspartate receptor in mature hippocampal cultures treated with amyloid-ß oligomers". Aging Cell 11 5 (2012): 823-833. http://www.scopus.com/inward/record.url?eid=2-s2.0-84866452758&partnerID=MN8TOARS.
    10.1111/j.1474-9726.2012.00848.x
  20. Costa, R.O.; Ferreiro, E.; Cardoso, S.M.; Oliveira, C.R.; Pereira, C.M.F.. "ER stress-mediated apoptotic pathway induced by aß peptide requires the presence of functional mitochondria". Journal of Alzheimer's Disease 20 2 (2010): 625-636. http://www.scopus.com/inward/record.url?eid=2-s2.0-77954516455&partnerID=MN8TOARS.
    10.3233/JAD-2010-091369
  21. Ferreiro, E.; Costa, R.; Marques, S.; Cardoso, S.M.; Oliveira, C.R.; Pereira, C.M.F.. "Involvement of mitochondria in endoplasmic reticulum stress-induced apoptotic cell death pathway triggered by the prion peptide PrP 106-126". Journal of Neurochemistry 104 3 (2008): 766-776. http://www.scopus.com/inward/record.url?eid=2-s2.0-38049162500&partnerID=MN8TOARS.
    10.1111/j.1471-4159.2007.05048.x
  22. Ferreiro, E.; Resende, R.; Costa, R.; Oliveira, C.R.; Pereira, C.M.F.. "An endoplasmic-reticulum-specific apoptotic pathway is involved in prion and amyloid-beta peptides neurotoxicity". Neurobiology of Disease 23 3 (2006): 669-678. http://www.scopus.com/inward/record.url?eid=2-s2.0-33747195017&partnerID=MN8TOARS.
    10.1016/j.nbd.2006.05.011
Manual
  1. Santos-Carvalho, Ana; Rui O Costa; Maria Inês Morte; Pedro Alves. Fisiologia Celular e Biologia Molecular. Portugal. 2013.
Preprint
  1. Pasqualino De Luca; Miranda Mele; Francesca Napoli; Philemon Mshelia; Rui O. Costa; Carlos B. Duarte. "BDNF-TrkB signaling promotes synaptic GluN2A-NMDA receptor expression and network hyperexcitability in cultured hippocampal neurons and during status epilepticus". 2025. https://doi.org/10.1101/2025.10.13.682007.
    10.1101/2025.10.13.682007
  2. Tahiri, Emanuel; Silva, Marta; Costa RO. Corresponding author: Costa RO. "When Brain Wiring Gets Tricky: Understanding Neurodevelopmental Disorders". 2025. https://kids.frontiersin.org.
Thesis / Dissertation
  1. "RNA-binding protein hnRNPH2: The role of RRM and NLS mutations in neuronal development and function". Master, Universidade de Coimbra, 2025. 2024-2025. Student: Ana Pinto. Thesis title: “RNA-binding protein hnRNPH2: The role of RRM and NLS mutations in neuronal development and function.” Faculty of medicine, University of Coimbra. MSc's Thesis in Molecular and translational neuroscience. Role: Supervisor. https://hdl.handle.net/10316/121173.
  2. "RNA-binding protein hnRNPH2: The role of NLS mutations in neuronal development and function". Master, Universidade de Coimbra, 2025. 1. 2024-2025. Student: Afonso Lourinho. Thesis title: “RNA-binding protein hnRNPH2: The role of NLS mutations in neuronal development and function.” Department of Life Sciences, Faculty of Science and Technology, University of Coimbra. MSc's Thesis in Cellular and Molecular Biology. Role: Supervisor. https://hdl.handle.net/10316/120572.
  3. "The Role of HNRNP H2 mutations in Epileptogenesis". Master, Università degli Studi di Napoli Federico II, 2025. 2024-2025. Student: Marco D'Ambrosio. Thesis title: “The Role of HNRNP H2 mutations in Epileptogenesis.” Università degli Studi di Napoli Federico II Università degli Studi del Sannio (Italy). Dipartimento di Scienze e Tecnologie dell’Università del Sannio Tesi di Laurea Magistrale in Farmacologia Molecolare. Corso di Laurea Magistrale in Biotecnologie Genetiche e Molecolari. Classe LM-9 delle Lauree Magistrali in Biotecnologie Mediche, Veterinarie e Farmaceutiche. Laurea Magistrale rilasciata in forma congiunta. Tesi di Laurea Magistrale in Farmacologia Molecolare. Role: Supervisor.
  4. "Characterisation of the RNA-binding protein hnRNP H2: a novel player in epileptogenesis". Master, Universidade de Coimbra, 2023. 2. 2022-2023. Student: Marta Silva. Thesis title: “Characterisation of the RNA-binding protein hnRNP H2: a novel player in epileptogenesis.” Department of Life Sciences, Faculty of Science and Technology, University of Coimbra. MSc's Thesis in Cellular and Molecular Biology. Role: Supervisor. https://hdl.handle.net/10316/110348.
  5. "Autophagosome biogenesis and axonal transport dysfunction in Alzheimer's disease". Master, Universidade de Coimbra, 2022. 2. 2021-2022. Student: Alexandra Santos. Thesis title: “Autophagosome biogenesis and axonal transport dysfunction in Alzheimer's disease.” Department of Life Sciences, Faculty of Science and Technology, University of Coimbra. MSc's Thesis in Cellular and Molecular Biology. Role: Supervisor. https://estudogeral.uc.pt/handle/10316/102862.
  6. "The impact of early life stress on anxiety and depression later in life: the contribution of MeCP2". Master, Universidade de Coimbra, 2022. 2021-2022. Student: Francisca Madeira. Thesis title: "The impact of early life stress on anxiety and depression later in life: the contribution of MeCP2.” Department of life Sciences, Faculty of Science and Technology, University of Coimbra. MSc's Thesis in Cellular and Molecular Biology. Role: Co-Supervisor. https://estudogeral.uc.pt/handle/10316/103157.
  7. "The role of the heterogeneous ribonucleoprotein H2 in neuronal development". Master, Università degli Studi di Napoli Federico II, 2022. 2021-2022. Student: Giovanna Di Pietro. Thesis title: “The role of the heterogeneous ribonucleoprotein H2 in neuronal development.” Università degli Studi di Napoli Federico II Università degli Studi del Sannio (Italy). Dipartimento di Scienze e Tecnologie dell’Università del Sannio Tesi di Laurea Magistrale in Farmacologia Molecolare. Corso di Laurea Magistrale in Biotecnologie Genetiche e Molecolari. Classe LM-9 delle Lauree Magistrali in Biotecnologie Mediche, Veterinarie e Farmaceutiche. Laurea Magistrale rilasciata in forma congiunta. Tesi di Laurea Magistrale in Farmacologia Molecolare. Role: Supervisor..
  8. "Novel roles for the KCC2 co-transporter in axons: regulation of chloride homeostasis and growth cone development". Master, Università degli Studi di Napoli Federico II, 2021. 2019-2020. Student: Giorgio Belperio. Thesis title: “Novel roles for the KCC2 co-transporter in axons: regulation of chloride homeostasis and growth cone development.” Università degli Studi di Napoli Federico II Università degli Studi del Sannio (Italy). Dipartimento di Scienze e Tecnologie dell’Università del Sannio Tesi di Laurea Magistrale in Farmacologia Molecolare. Corso di Laurea Magistrale in Biotecnologie Genetiche e Molecolari. Classe LM-9 delle Lauree Magistrali in Biotecnologie Mediche, Veterinarie e Farmaceutiche. Laurea Magistrale rilasciata in forma congiunta. Tesi di Laurea Magistrale in Farmacologia Molecolare. Role: Supervisor..
  9. "Determine if intra-axonal mRNA translation occurs at discrete “hot spots” during synapse formation". Master, Universidade de Aveiro, 2021. 2020-2021. Student: Guilherme Trigo. “Determine if intra-axonal mRNA translation occurs at discrete “hot spots” during synapse formation.” (2020-2021). Department of Medical Sciences, University of Aveiro. MSc's Thesis in Molecular Biomedicine. Role: Co- Supervisor. http://hdl.handle.net/10773/33029.
  10. "Alteration of neuronal networks in epilepsy: the role of the K+-Cl- cotransporter KCC2.". Master, Università degli Studi del Sannio, 2021. 2020-2021. Student: Claudia Corso. “Alteration of neuronal networks in epilepsy: the role of the K+-Cl- cotransporter KCC2.” Dipartimento di Scienze e Tecnologie, Corso di Laurea Magistrale in Biologia, Università degli studi del Sannio (Italy). Tesi di Laurea Magistrale in Basi farmacologiche della terapia. Role: Co-Supervisor..
  11. "Early autophagy dysfunction in Alzheimer’s disease: the role of Wipi2.". Master, Universidade de Coimbra, 2021. 2020-2021. Student: Emanuel Tahiri. “Early autophagy dysfunction in Alzheimer’s disease: the role of Wipi2.” Department of life Sciences, Faculty of Science and Technology, University of Coimbra. MSc's Thesis in Cellular and Molecular Biology. Role: Supervisor. https://estudogeral.uc.pt/handle/10316/99427.
  12. "Ribosomal regulation Axonal development". Degree, Universidade de Coimbra, 2014. Student: Helena Sofia Caria Martins. Thesis title: “Ribosomal regulation Axonal development.” Department of life Sciences, Faculty of Science and Technology, University of Coimbra. MSc's Thesis in Cellular and Molecular Biology. Role: Co-supervisor. https://hdl.handle.net/10316/30759.
  13. "Endoplasmic reticulum stress during amyloid ß peptide-induced cell death : role of mitochondria and glutamatergic N-methyl-D-aspartate receptors". PhD, Universidade de Coimbra, 2011. http://hdl.handle.net/10316/18243.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2025/01/31 The RNA-binding protein hnRNPH2: a novel player in epileptogenesis. HNRNP-RNDD Virtual Scientific Symposium. International meeting
2024/12/20 The RNA-binding protein hnRNPH2: a novel player in epileptogenesis. CiBB meeting 2024 - Flash talks, December 20, 2024.
CiBB meeting 2024 - Flash talks, December 20, 2024. (Anadia, Portugal)
2024/03/08 The RNA-binding protein hnRNPH2: a novel player in epileptogenesis. Rui received the award for best oral communication. 36th National Epileptology Meeting (ENE), Coimbra, Portugal
Liga Portuguesa contra a Epilepsia (Coimbra, Portugal)
2024 Unravelling the impact of amyloid-ß oligomers on intra-axonal autophagy dysregulation in Alzheimer's disease Emanuel Tahiri, Alexandra Santos, Marta Silva, Carlos Bandeira Duarte, Rui O. Costa. 38a Reunião do Grupo de Estudos de Envelhecimento Cerebral e Demência
(braga, Portugal)
2023/12/12 How to study a Rare Neurodevelopmental disorder?” Department of Life Sciences (DCV) Talks, University of Coimbra, Coimbra, Portugal.
Department of Life Sciences (DCV) Talks, University of Coimbra, Coimbra, Portugal. (Coimbra, Portugal)
2023/11/04 Strategies to study intra-axonal neurodegenerative mechanisms in Alzheimer's disease ISN-ESN Advanced School 2023
ISN-ESN Advanced School 2023 (Faro, Portugal)
2022/06 Amyloid-ß oligomers impair intra-axonal autophagy GEECD 2022
(Portugal)
2022/06 The role of intra-axonal autophagy in Alzheimer’s disease GEECD 2022
(Portugal)
2022/04/23 Da ideia à publicação dos resultados: Como se faz (neuro)ciência? MeetLAB (VI meet.Lab; https://pt-br.facebook.com/meet.LabCoimbra/)
Meet.LAB (Coimbra, Portugal)
2020/06/03 Synaptogenesis stimulates a proteasome-mediated ribosome reduction in axons Portuguese Postdoc exchange program
Instituto Gulbenkian de Ciência (ICG) - Portugal (WEBINAR, Portugal)
2017/02 Axonal regulation of ribosome content during development XLVII Reunião Anual da Sociedade Portuguesa de Farmacologia
Sociedade Portuguesa de Farmacologia (Coimbra, Portugal)
2017/02 Local application of MSCs secretome induces axonal elongation in CNS neurons XLVII Reunião Anual da Sociedade Portuguesa de Farmacologia
Sociedade Portuguesa de Farmacologia (Coimbra, Portugal)
2013/06 Oxidative and ER stress in early stages of Alzheimer’s disease 13a Reunião da Sociedade Portuguesa de Neurociências
Sociedade Portuguesa de Neurociências (Luso, Portugal)
2013/04 Excitotoxicity and oxidative stress in early stages of Alzheimer's Disease Oxidative Stress & Disease -The Metabolic-Inflammatory Axis in Brain Aging and Alzheimer's Disease Gordon Conference
Gordon Conference (Les Diablerets, Switzerland)
2013/03/23 Alzheimer’s Disease: Biochemical Approaches to Molecular Mechanisms VI Encontro Nacional de Estudantes de Bioquímica
VI Encontro Nacional de Estudantes de Bioquímica (Aveiro, Portugal)
2012/06 Changes in oxidative and endoplasmic reticulum stress in human peripheral blood mononuclear cells during early stages of Alzheimer’s disease 26a Reunião Grupo de Estudos de Envelhecimento Cerebral e Demências
Grupo de Estudos de Envelhecimento Cerebral e Demências (Tomar, Portugal)
2012/03/17 Percurso académico e ciêntifico. O nosso actual trabalho laboratorial. Simpósio:Jovens cientistas no IEC
Instituto de Educação e Cidadania (IEC) (Mamarrosa, Oliveira do bairro, Portugal)
2010/06 Loss of endoplasmic reticulum calcium homeostasis in Alzheimer’s disease 24a Reunião Grupo de Estudos de Envelhecimento Cerebral e Demências
Grupo de Estudos de Envelhecimento Cerebral e Demências (Tomar, Portugal)
2010/06 Neuroprotection by leptin and ghrelin against amyloid-beta toxicity in hippocampal neurons. Relevance for therapeutic intervention in Alzheimer’s disease 24a Reunião Grupo de Estudos de Envelhecimento Cerebral e Demências
Grupo de Estudos de Envelhecimento Cerebral e Demências (Tomar, Portugal)
2010/06 Changes in NMDA receptor subunits expression in 3xTg-AD mice and human peripheral blood cells 24a Reunião Grupo de Estudos de Envelhecimento Cerebral e Demências
Grupo de Estudos de Envelhecimento Cerebral e Demências (Tomar, Portugal)
2009/06 Endoplasmic reticulum stress in hippocampal neurons induced by Alzheimer’s disease-Associated amyloid-beta oligomers. Role of NR2A and NR2B subunits of N-Methyl-D-ASpartate (NMDA) receptor 23a Reunião Grupo de Estudos de Envelhecimento Cerebral e Demências
Grupo de Estudos de Envelhecimento Cerebral e Demências (Luso, Portugal)
2008/06 O envolvimento mitocondrial na apoptose mediada pelo retículo endoplasmático na doença de Alzheimer 22a Reunião Grupo de Estudos de Envelhecimento Cerebral e Demências
Grupo de Estudos de Envelhecimento Cerebral e Demências (Luso, Portugal)
2007/06 Disfunção do retículo endoplasmático em cíbridos de doentes de Alzheimer 21a Reunião Grupo de Estudos de Envelhecimento Cerebral e Demências
Grupo de Estudos de Envelhecimento Cerebral e Demências (Luso, Portugal)
2006/12 Endoplasmic reticulum-specific apoptotic pathway induced by prion and amyloid-beta peptides. XXXVII Reunião Anual da Sociedade Portuguesa de Farmacologia e XXIV Reunião de Farmacologia Clínica
Sociedade Portuguesa de Farmacologia (Porto, Portugal)
2006/06 Role of mitochondria in the endoplasmic reticulum-mediated apoptosis induced by the amyloid-beta peptide 20a Reunião Grupo de Estudos de Envelhecimento Cerebral e Demências
Grupo de Estudos de Envelhecimento Cerebral e Demências (Tomar, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2024/03 - Current Study the role of ATG16 in intra-axonal autophagy in Alzheimer’s disease.
Supervisor
 Corso di Laurea Magistrale in Biologia. Tesi di Laurea Magistrale in Basi farmacologiche della terapia. (Master)
Università degli Studi del Sannio, Italy
2022/10 - Current Autophagy dysfunction in axons: new evidence for Alzheimer´s disease pathogenesis UI/BD/154202/2022
Supervisor of Emanuel Tahiri
 Doutoramento em neurociências - Experimental Biology and Biomedicine (BEB) (PhD)
Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal

Universidade de Coimbra, Portugal
2024/09/01 - 2025 RNA-binding protein hnRNPH2: The role of RRM2 mutations in neuronal development and function
Supervisor
 master in molecular and translational neuroscience (Master)
Universidade de Coimbra Faculdade de Medicina, Portugal
2024/09/01 - 2025 RNA-binding protein hnRNPH2: The role of NLS mutations in neuronal development and function
Supervisor of Afonso Lourinho
 Master's Thesis in Cellular and Molecular Biology (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2024/03 - 2025 The Role of HNRNP H2 mutations in Epileptogenesis.
Supervisor of Marco D'Ambrosio
 Tesi di Laurea Magistrale in Farmacologia Molecolare. Corso di Laurea Magistrale in Biotecnologie Genetiche e Molecolari (Master)
Università degli Studi del Sannio Dipartimento di Scienze e Tecnologie, Italy
2022/09/01 - 2023/09/18 The RNA-binding protein hnRNPH2: a novel player in epileptogenesis
Supervisor of Marta Sofia Santos Silva
 Biologia Celular e Molecular (Master)
Universidade de Coimbra, Portugal
2022/03/01 - 2023/02/24 The role of heterogeneous ribonuclear proteins in Epilepsy and autism spectrum disorders.
Supervisor of Giovanna Di Pietro
 Corso de Laurea Magistrale in Biotecnologie Genetiche e Molecolari
Università degli Studi del Sannio, Italy

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2021/10 - 2022/09 Autophagosome biogenesis and axonal transport dysfunction in Alzheimer’s disease
Supervisor of Alexandra Filipa Almeida Santos
 Biologia Celular e Molecular (Master)
Universidade de Coimbra, Portugal
2021/09 - 2022/09 The impact of early life stress on anxiety and depression later in life: the contribution of MeCP2
Co-supervisor
 Biologia Celular e Molecular (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2020/09/10 - 2021/12/13 Determine if intra-axonal mRNA translation occurs at discrete “hot spots” during synapse formation
Co-supervisor of Guilherme Gomes Trigo
 Biomedicina Molecular (Master)
Universidade de Aveiro, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2020/09/10 - 2021/10/01 Early autophagy dysfunction in Alzheimer’s Disease: the role of WIPI2
Supervisor of Emanuel Tahiri
 Biologia Celular e Molecular (Master)
Università degli Studi del Sannio, Italy

Universidade de Coimbra, Portugal
2020/03/01 - 2021/02/24 Novel roles for the KCC2 co-transporter in axons: regulation of chloride homeostasis and growth cone development.
Co-supervisor of Giorgio Belperio
 Corso de Laurea Magistrale in Biotecnologie Genetiche e Molecolari (Master)
Università degli Studi di Napoli Federico II, Italy

Università degli Studi del Sannio, Italy

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2013 - 2014/09/08 Modulation of synaptic mRNA composition
Co-supervisor of Helena Sofia Caria Martins
 Ribosomal regulation Axonal development (Master)
Universidade de Coimbra, Portugal

Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2024 - Current 2024: Co-Organizer, “Well Being for Scientists II” – an initiative led by PostDoc representatives focusing on the topic of mental health within the CIBB community. December 5th-6th 2024) (2024)
2023 - Current "Un viaggio nei meccanismi della memoria" (https://www.futuroremoto.eu/programma-completo-futuro-remoto-2023-online/) as part of the XXXVII edition of "Futuro Remoto," (https://www.futuroremoto.eu/archivio-%c2%b7-programma-edizione-2023-%c2%b7-napoli/) a science dissemination event held both in-person at Città della Scienza, Naples (Italy), and remotely. The Futuro Remoto event in 2023 received recognition from the President of the Italian Republic. (2023)
2023 - Current “Meet My Science” (2023–2025), a seminar series initiated by PostDoc representatives at CIBB to spotlight ongoing research. (2023)
Seminar (Co-organisor)
2021/11/19 - Current Seminar: Amyloid beta oligomers in neurodegeneration and neurodevelopment. Professor William Klein, Department of Neurobiology, Weinberg College o Arts & Sciences, Northwestern University, USA Friday, November 19, 2021, 3 pm @ Zoom Meeting Host: Rui O. Costa, CNC www.cnc.uc.pt/pt/seminars (2021/11/19)
Seminar (Co-organisor)
 Universidade de Coimbra, Portugal
2025/06/03 - 2025/06/03 2025: Co-Organizer, “Meet Our Job - Alternativas à Carreira de Investigação Científica” – An initiative led by PostDoc representatives aimed to connect students and researchers with professionals who have successfully transitioned into alternative careers outside the often-unstable realm of academic research. The event was open to the UC health sciences community (>140 participants). June 3rd, 2025. (2025)
2019 - 2022 “CNC Weekly Seminars” (2019–2022), fostering regular scientific discussions within the community. (2019 - 2023)
Seminar (Co-organisor)
2012 - 2014 Co-organizer of the Cell Physiology and Molecular Biology course lectured in the highschool “Escola secundária de Oliveira do Bairro (ESOB)” (4 courses of 10 classes, 3 hours each. Total = 120 hours). Co-author of protocol manual book used in Cell Physiology and Molecular Biology courses lectured in the highschool “Escola secundária de Oliveira do Bairro (ESOB)”. (2012 - 2014)
Other (Co-organisor)
 Instituto de Educação e Cidadania, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2025 - Current HNRNP-RNDD Virtual Scientific Symposium, January 31st, 2025. Invited Speaker.
Symposium
2024 - Current 36th National Epileptology Meeting (ENE), Coimbra, Portugal, March 8th-9th, 2024. Received the prize of best oral presentation.
Meeting
2022/04/23 - Current Invited speaker at the VI meet lab. O meet.Lab Coimbra é um evento organizado pelo Núcleo de Estudantes de Biologia da Associação Académica de Coimbra, com uma forte vertente de laboratório.
Meeting
 MeetLAB (VI meet.Lab; https://pt-br.facebook.com/meet.LabCoimbra/)
2022 - Current HNRNP-Related Neurodevelopmental Disorder Scientific Symposium 2022
Symposium
 HNRNP-Related Neurodevelopmental Disorder Scientific Symposium 2022
2015/11/19 - Current workshops@IIIUC, intitulada: “"Grant proposals: funding opportunities and writing tips”
Workshop
 Grant proposals: funding opportunities and writing tips
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2006 - Current Collaborator in “Brain Awarness Week” , at the Center for Neuroscience and Cell Biology (CNC), University of Coimbra. “Brain Awarness Week”
CNC.IBILI, Portugal
2006 - Current Collaborator in “Ciência Viva” programme, at the Center for Neuroscience and Cell Biology (CNC), University of Coimbra. “Ciência Viva” programme
CNC.IBILI, Portugal
2021/12/01 - 2021/12/03 XVII Meeting of the Portuguese Society for Neuroscience – SPN2021, Coimbra, Portugal, from 1– 3 December 2021
Meeting
 XVII Meeting of the Portuguese Society for Neuroscience – SPN2021
2021/10/04 - 2021/10/07 EMBO Workshop Axons 2021; structure and function 4-7 October 2021. Participated with the poster: Thu-PO-3-19 Intra-axonal autophagy dysfunction in Alzheimer¿s disease. Rui O. Costa, Emanuel Tahiri, Marta Silva, Carlos B. Duarte
Workshop
 EMBO Workshop: Axons 2021: structure and function
2021/03/12 - 2021/03/13 Congresso virtual da LPCE (33º eENE)
Congress
 Congresso virtual da LPCE (33º eENE)
2020/01/23 - 2020/01/24 The Neurobiology of Socio-Sexual Behavior (6h of Lectures). This mini symposium was organized by the Center for Neuroscience and Cell Biology and the Master Program in Cellular and Molecular Biology of the University of Coimbra.
Symposium
 The Neurobiology of Socio-Sexual Behavior
CNC.IBILI, Portugal

Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
2016/06/17 - 2016/06/24 Workshop de Aceleração de Ideias de Negócio “Ideation Week Experience 2016 (Duration 12h).
Workshop
 Workshop de Aceleração de Ideias de Negócio “Ideation Week Experience 2016
Instituto de Investigação Interdisciplinar da Universidade de Coimbra, Portugal
2016/06/01 - 2016/06/04 ISN 2016 meeting, Coimbra, Portugal.
Meeting
 ISN 2016 (international society for neurochemistry)
2014/11/15 - 2014/11/19 SFN 2014 meeting, Washington DC, USA.
Meeting
 SFN 2014 meeting (Society for Neuroscience)
2012 - 2014 Collaborator in activities promoted by Instituto de Educação e Cidadania (IEC) regarding Science awareness. Advanced courses in Biology for students and high school teachers - "Curso avançado de Biologia Do gene à Proteína"
Other
 Collaborator in activities promoted by Instituto de Educação e Cidadania (IEC) regarding Science awareness
Instituto de Educação e Cidadania, Portugal
2013/05/27 - 2013/05/27 Workshop: "Grant Writing and Funding Opportunities"
Workshop
 Workshop: "Grant Writing and Funding Opportunities"
Instituto de Investigação Interdisciplinar da Universidade de Coimbra, Portugal
2012/12/04 - 2012/12/06 Advanced fluorescence microscopy workshop. Training content: Widefield fluorescence microscopy; Confocal Microscopy (LSM 700); Strutured Ilummination Microoscopy (APOTOME); Zen imaging software. Coimbra, Portugal
Workshop
 Advanced fluorescence microscopy workshop
CNC.IBILI, Portugal
2010/11/29 - 2010/12/03 Image processing and analysis in cell physiology. Advanced Training Workshop Department of Biology, University of Aveiro, 3810-193 Aveiro, Portugal.
Workshop
 Image processing and analysis in cell physiology.
Universidade de Aveiro, Portugal
2010/07/03 - 2010/07/07 7th FENS, Fórum of European Neuroscience, Amsterdam, The Neatherlands.
Meeting
 7th FENS, Forum of European Neuroscience
2010/04/13 - 2010/04/13 Technical Seminar: “RNA World: not so small”. CNC, University of Coimbra, Portugal.
Seminar
 “RNA World: not so small”.
CNC.IBILI, Portugal
2010/01/11 - 2010/01/15 Gene Therapy and Nuclear Biology. Advanced course of PDBEB, CNC, University of Coimbra, Portugal. 2010, January 11th-15th.
Other
 Gene Therapy and Nuclear Biology. Advanced course of PDBEB, CNC.
CNC.IBILI, Portugal
2009/09/02 - 2009/09/04 Course on Multifluorescence Microscopy. Training content: Confocal Microscopy (LSM 700); Strutured Ilummination Microoscopy (APOTOME). Coimbra, Portugal. 2009, September 2nd-4th.
Workshop
 Course on Multifluorescence Microscopy
CNC.IBILI, Portugal
2009/06/25 - 2009/06/26 24a Reunião Grupo de Estudos de Envelhecimento Cerebral e Demências, Tomar, Portugal.
Meeting
 24a Reunião Grupo de Estudos de Envelhecimento Cerebral e Demências, Tomar, Portugal.
2009/03/11 - 2009/03/15 9th Internacional Conferente AD/PD, Prague, Czech Republic.
Conference
 9th Internacional Conferente AD/PD, Prague, Czech Republic.
2008/06 - 2009/03 Course IBiS 417 - Interdepartmental Biological Sciences (IBiS) - "Structural and Cell Biology of Alzheimer's Disease" given by Doctor William L. Kein, at Northwestern University, Evanston, Chicago. 2008, September-March.
Other
 Course IBiS 417 - Interdepartmental Biological Sciences (IBiS) - "Structural and Cell Biology of Alzheimer's Disease" lectured by Doctor William L. Kein
Northwestern University - Chicago, United States
2008/06/26 - 2008/06/27 23a Reunião Grupo de Estudos de Envelhecimento Cerebral e Demências, Luso, Portugal.
Meeting
 23a Reunião Grupo de Estudos de Envelhecimento Cerebral e Demências, Luso, Portugal.
2008/06/12 - 2008/06/16 6th FENS, Fórum of European Neuroscience, Geneva, Switzerland.
Meeting
 6th FENS, Fórum of European Neuroscience, Geneva, Switzerland.
2008/06/06 - 2008/06/07 22a Reunião Grupo de Estudos de Envelhecimento Cerebral e Demências, Luso, Portugal.
Meeting
 22a Reunião Grupo de Estudos de Envelhecimento Cerebral e Demências, Luso, Portugal.
2007/06/08 - 2007/06/09 21a Reunião Grupo de Estudos de Envelhecimento Cerebral e Demências, Luso, Portugal.
Meeting
 21a Reunião Grupo de Estudos de Envelhecimento Cerebral e Demências, Luso, Portugal.
2007/05/25 - 2007/05/26 Meeting Portuguese Society for Neurosciences, Ofir, Portugal.
Meeting
 Meeting Portuguese Society for Neurosciences, Ofir, Portugal.
2007/01/29 - 2007/02/02 Neurogenesis and Neural Stem Cells. Advanced course of PDBEB (Doctoral program), CNC, University of Coimbra, Portugal.
Other
 Neurogenesis and Neural Stem Cells. Advanced course of PDBEB (Doctoral program), CNC, University of Coimbra, Portugal. 2007, January 29th-February 2nd.
CNC.IBILI, Portugal
2007/01/22 - 2007/01/26 Neurodegenerative Diseases. Advanced course of PDBEB (Doctoral program), CNC, University of Coimbra, Portugal.
Other
 Neurodegenerative Diseases. Advanced course of PDBEB (Doctoral program)
CNC.IBILI, Portugal
2007/01/15 - 2007/01/19 Cell Death and Survival Signalling. Advanced course of PDBEB (Doctoral program), CNC, University of Coimbra, Portugal.
Other
 Cell Death and Survival Signalling. Advanced course of PDBEB (Doctoral program)
CNC.IBILI, Portugal
2007/01/08 - 2007/01/10 Biostatistics. Advanced course of PDBEB (Doctoral program), CNC, University of Coimbra, Portugal
Other
 Biostatistics. Advanced course of PDBEB (Doctoral program)
CNC.IBILI, Portugal
2006/12/08 - 2006/12/10 XV National Congress of Biochemistry (“Congresso Nacional de Bioquímica”), Aveiro, Portugal.
Congress
 XV National Congress of Biochemistry (“Congresso Nacional de Bioquímica”), Aveiro, Portugal.
2006/11/23 - 2006/11/24 V Congresso de Investigação em Medicina, Coimbra, Portugal.
Congress
 V Congresso de Investigação em Medicina (Congress on Investigation in Medicine), Coimbra, Portugal.
2006/06/23 - 2006/06/24 20a Reunião Grupo de Estudos de Envelhecimento Cerebral e Demências, Tomar, Portugal.
Meeting
 20a Reunião Grupo de Estudos de Envelhecimento Cerebral e Demências, Tomar, Portugal.

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2025 Catarina Catarina Pinho Neves | Dissertation: " Stress-driven alterations in cortical mitochondrial function: from cellular to early-life models" | MSc in Molecular Biomedicine, University of Aveiro. | Supervisors: Dr. Ana Cristina Carvalho Rego, Dr. Luís Manuel Souto de Miranda. | Presented to: Department of Medical Sciences, University of Aveiro. 2025
(Thesis) Main arguer
 Catarina Catarina Pinho Neves (Master)
Universidade de Aveiro, Portugal
2024 Catarina Filipa Guerreiro de Oliveira | Dissertation: "The role of a-synuclein in neuronal innate immunity activation: Implications to Parkinson’s disease" | MSc in Cellular and Molecular Biology (Neurobiology Specialization), University of Coimbra. | Supervisors: Professor Sandra Morais Cardoso & Professor João Peça. | Presented to: Department of Life Sciences, University of Coimbra. September 2024.
(Thesis) Main arguer
 Catarina Filipa Guerreiro de Oliveira (Master)
2023 Rafael de Oliveira Patarra | Dissertation: "Developing techniques to assess and optimize the efficiency of targeted protein degradation strategies for tau in the context of Alzheimer’s disease" | MSc in Cellular and Molecular Biology (Neurobiology Specialization), University of Coimbra. | Supervisor: Dr. Géraldine Gelders. Presented to: Faculty of Science and Technology, University of Coimbra. July 2023.
(Thesis) Main arguer
 Rafael de Oliveira Patarra (Master)
Universidade de Coimbra, Portugal
2021/12 Perturbation of endoplasmic reticulum-mitochondria crosstalk in bipolar disorder: effect of sigma-1 receptor modulation
(Thesis) Main arguer
 Ana Rita Azevedo Henriques da Cunha (Master)
Universidade de Coimbra, Portugal
2021/10/11 Early autophagy dysfunction in Alzheimers disease: the role of WIPI2
Supervisor
 Emanuel Tahiri (Master)
Universidade de Coimbra, Portugal
2021 Desenvolvimento de um hidrogel de lisados de plaquetas para indução de regeneração nervosa
(Thesis) Main arguer
 Joana Filipa Ribeiro Correia (Master)
Universidade de Aveiro, Portugal
2020/09/24 LAEB - Defesa de Monografia: "Development of new hydrogels for stem-cell differentiation"
(Thesis) Main arguer
 Sofia Catarina Ponce Dias (Master)
Universidade de Aveiro Departamento de Física, Portugal
2019/09/12 Characterization of the intracelular signalling pathways mediating the effects of purinergic receptors in dendritic and axonal formation and outgrowth
(Thesis) Main arguer
 João Miguel Miranda da Rocha (Master)
Universidade de Coimbra, Portugal

Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2019/09/03 Study of Tau and Synaptogyrin-3 interaction - A drug discovery approach
(Thesis) Main arguer
 Ana Filipa Martins de Oliveira (Master)
Hospitais da Universidade de Coimbra, Portugal

Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2018/07/27 Development of immunoassays on the Simoa platform to detect and differentiate Tau species at very low concentrations
(Thesis) Main arguer
 Dina Rodrigues Martins (Master)
Universidade de Coimbra, Portugal

Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2017/07/13 Assaying synaptic function using genetically -encoded optical reporters in the context of Alzheimer´s disease
(Thesis) Main arguer
 Catarina Franco Quitério de Oliveira Borges (Master)
Universidade de Coimbra, Portugal

Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2016/09/12 Scale for mapping the brain: the role of stargazin in regulating dendritic spine morphology
(Thesis) Main arguer
 Joana de Freitas Fresco Rodrigues Costa (Master)
Universidade de Coimbra, Portugal

Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2016/07/28 Apreciação do Projecto de tese: "The Role of endocytosis in BDNF-induced axonal outgrowth and branching"
(Thesis) Main arguer
 Luís Filipe Maximino Martins (PhD)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2015/07/13 The role of autophagy and the lysosomal pathway in the clearance of Tau aggregates
(Thesis) Main arguer
 Alberto José Carpinteiro Soares (Master)
Universidade de Coimbra, Portugal

Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2014/07/16 Microtubule-targeting agents: a therapeutic strategy in neurodegenerative diseases
(Thesis) Main arguer
 Nuno Miguel Ferreira Morais Apóstolo (Master)
Universidade de Coimbra, Portugal

Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Ad Hoc journal article review

Journal title (ISSN) Publisher
2021/10 - Current Aging Cell
2017 - Current Biochimica et Biophysica Acta (BBA) - General Subjects (0304-4165) Elsevier
2017 - Current Heliyon (2405-8440) Elsevier
2017 - Current Oxidative Medicine and Cellular Longevity (1942-0994) Hindawi Limited
2016 - Current Neurochemical Research (1573-6903) Springer-Verlag
2015 - Current Data in Brief (2352-3409) Elsevier

Association member

Society Organization name Role
2023 - Current International Society for Neurochemistry (ISN) member
2023 - Current European Society for Neurochemistry (ESN member
2021/02 - Current Liga Portuguesa contra a Epilepsia (LPCE) Member (Sócio)
2006 - Current Sociedade Portuguesa de Neurosciências (Portuguese Society for Neurosciences) Member
2006 - Current Sociedade Portuguesa de Bioquímica (Portuguese society for Biochemistry) Member

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2025/03/26 - Current Cellular and Molecular Neurobiology | Neurobiology and Disease | Lecture: Neuromuscular Junction Development (March 26, 2025); Duration: 1 hour (Mestrado) Universidade de Coimbra, Portugal
2025/03/11 - Current Cellular and Molecular Neurobiology | Lecture: Presynaptic Differentiation and Synaptogenesis (November 3, 2025) (Mestrado) Universidade de Coimbra, Portugal
2024/11/08 - Current Cellular and Molecular Neurobiology | Lecture: Presynaptic Differentiation and Synaptogenesis (November 8, 2024); Duration: 1 hour MSc in Cellular and Molecular Biology Universidade de Coimbra, Portugal
2024/05/24 - Current From idea to publication of results: Cell cultures and other strategies. Ciências Biomédicas (Licenciatura) Universidade do Algarve, Portugal
2024/04/05 - Current Neurobiology and Disease Course | Neurobiology and Disease | Lecture: Neuromuscular Junction Development (April 5, 2024); Duration: 1 hour (Mestrado) Universidade de Coimbra, Portugal
2022/11/25 - Current Lecturer at the Celular and Molecular Neurobiology of the Master in Cellular and Molecular Biology, Master in Computational biology and Master in Biochemistry at the Faculty of science and technology, University of Coimbra. 2022, November 25th. (Lecture topic: Synaptogenesis (Presynaptic differentiation and synaptogenesis). Total = 1.25 hours) (MBC, MBCM, MBIOQ, MNMT) Biologia Celular e Molecular (Mestrado integrado) Universidade de Coimbra, Portugal
2022/02/07 - Current Lecturer at the doctoral program - PDBEB course on 'Synapse Biology', University of Coimbra. 2022, February 7th. (1 Lecture on the - Establishment of neuronal polarity and axon pathfinding, Total = 1 hours) Programa doutoral em Experimental Biology and Biomedicine (BEB) (Curso de doutoramento (conclusão de unidades curriculares)) Center for Neurosciences and Cell Biology, University of Coimbra, Portugal
2021/11/03 - Current Lecturer at the Celular and Molecular Neurobiology of the Master in Cellular and Molecular Biology, Master in Computational biology and Master in Biochemistry at the Faculty of science and technology, University of Coimbra. 2021, November 3rd. (Lecture topic: Synaptogenesis (Presynaptic differentiation and synaptogenesis). Total = 1.4 hours) (MBC, MBCM, MBIOQ, MNMT) Biologia Celular e Molecular (Mestrado integrado) Universidade de Coimbra, Portugal
2021/03/22 - Current Lecturer at the doctoral program - PDBEB course on 'Synapse structure and function', University of Coimbra. 2021, March 22th. (1 Lecture on the - Establishment of neuronal polarity and axon pathfinding, Total = 1 hours) Experimental Biology and Biomedicine (BEB) Center for Neurosciences and Cell Biology, University of Coimbra, Portugal
2019/04/09 - Current Lecturer at the Neurobiology and Disease course of the Master in Cellular and Molecular Biology. Faculty of science and technology, University of Coimbra. 2019, April 9th. (Lecture on the ¿Development of the nervous system and neuronal polarity and axon pathfinding¿, Total = 3 hours) Biologia Celular e Molecular (Mestrado integrado) Universidade de Coimbra, Portugal
2014 - Current Supervisor of laboratory rotations for students of the Master in Cell and Molecular Biology, University of Coimbra, Portugal. (Mestrado) Universidade de Coimbra, Portugal
2026/01/05 - 2026/01/09 Neuroscience Courses 2025: Synapse Function, and Plasticity | Experimental work: Study of Axonal Transport and Analysis with Kymographs (January 5-9, 2026); Duration: 25 hours Doctoral Program in Experimental Biology and Biomedicine (PDBEB) International Doctoral Program in Integrative Neuroscience (idPIN) CNC-Center for Neuroscience and Cell Biology, University of Coimbra (Curso de doutoramento (conclusão de unidades curriculares)) Universidade de Coimbra, Portugal
2024/05 - 2025/05 Neurobiology course, University of Algarve (Licenciatura) Universidade do Algarve, Portugal
2025/01/06 - 2025/01/10 Neuroscience Courses 2025: Synapse Assembly, Function, and Plasticity | Experimental work: Study of Axonal Transport and Analysis with Kymographs (January 6-10, 2025); Duration: 25 hours (Curso de doutoramento (conclusão de unidades curriculares)) Universidade de Coimbra, Portugal
2024/03/18 - 2024/03/20 Methods and Techniques in Molecular Biology (Laboratory Practices), University of Coimbra (Licenciatura) Universidade de Coimbra, Portugal
2024/01/29 - 2024/02/02 Neuroscience Courses 2024: Synapse Assembly, Function, and Plasticity | Lecture: Presynaptic Differentiation and Synaptogenesis (January 30, 2024); Duration: 1 hour | Experimental work: Study of Axonal Transport and Analysis with Kymographs (January 29-February 2, 2024); Duration: 25 hours (Curso de doutoramento (conclusão de unidades curriculares)) Universidade de Coimbra, Portugal
2023/02/27 - 2023/03/01 Lecturer at the Neurobiology course of the Biology degree at University of Coimbra, Portugal. 2023, February 27th-March 1st. Discipline: Médodos e Técnicas em Biologia Molecular (Práticas-laboratoriais) Total = 18 hours) Biologia (Licenciatura) Universidade de Coimbra, Portugal
2023/01/16 - 2023/01/20 Lecturer at the doctoral program - PDBEB course on 'Synapse assembly, function and plasticity (16-20 January 2023). 1 Lecture on the - Study of axonal transport and analysis with kymographs , Total = 1 week) programa doutoral BEB Universidade de Coimbra, Portugal
2022/12/02 - 2022/12/05 Lecturer at the Celular and Molecular Neurobiology of the Master in Cellular and Molecular Biology, Master in Computational biology and Master in Biochemistry at the Faculty of science and technology, University of Coimbra. 2022, December 2th and 5th. (Lecture topic: Synaptogenesis (Presynaptic differentiation and synaptogenesis, presentation of final works). Total = 6 hours) (MBC, MBCM, MBIOQ, MNMT) Biologia Celular e Molecular (Mestrado integrado) Universidade de Coimbra, Portugal
2022/03/28 - 2022/03/30 Lecturer at the Neurobiology course of the Biology degree at University of Coimbra, Portugal. 2022, March 28th-30th. Discipline: Médodos e Técnicas em Biologia Molecular (Práticas-laboratoriais) Total = 18 hours) Biologia (Licenciatura) Universidade de Coimbra, Portugal
2022/01/10 - 2022/01/10 Invited lecturer at the Neurobiology course of the Biochemistry degree at University of Algarve, Portugal. 2022, January 10th. (1 Lecture on neuronal development, Total = 2 hours) Bioquímica (Licenciatura) Universidade do Algarve, Portugal
2021/01/04 - 2021/01/04 Invited lecturer at the Neurobiology course of the Biochemistry degree at University of Algarve, Portugal. 2021, January 4th. (1 Lectures on neuronal development, Total = 2 hours) Bioquímica (Licenciatura) Universidade do Algarve, Portugal
2019/10/08 - 2019/10/08 Lecturer at the Cell regulation course of the Master in Cellular and Molecular Biology. Faculty of science and technology, University of Coimbra. 2019, October 8th. (Total = 2.5 hours) Biologia Celular e Molecular (Mestrado integrado) Universidade de Coimbra, Portugal
2019/03/25 - 2019/03/26 Lecturer at the Neurobiology and Disease course of the Master in Cellular and Molecular Biology. Faculty of science and technology, University of Coimbra. 2019, March 25th-26th. (4 Lectures on the “Development of the nervous system and neuronal polarity and axon pathfinding”, Total = 4.5 hours) Biologia Celular e Molecular (Mestrado) Universidade de Coimbra, Portugal
2012 - 2014 Teacher of an Experimental Science Course – Cell Physiology and Molecular Biology lectured in the highschool “Escola Secundária de Oliveira do Bairro (ESOB)”, for students of “9º ano de escolaridade”. (4 courses of 10 classes, 3 hours each. Total = 120 hours) Cell Physiology and Molecular Biology (Ensino secundário) Instituto para a Educação e a Cidadania, Portugal
2013 - 2013 Invicted lecturer. Neurosciences pratical classes integrated in the Master degree in Medicine, University of Coimbra. “Diverse Approaches To Molecular Mechanisms”. 1 lecture. Total = 3h Medicina (Mestrado integrado) Universidade de Coimbra, Portugal
2012 - 2013 Teacher in the Course "Do gene à proteína", lectured in the “Instituto para a Educação e a Cidadania (IEC), host in Mamarrosa, concelho de Oliveira do Bairro, Portugal. For highschool students. (8 classes, 3 hours each. Total = 24 hours) (Ensino secundário) Instituto para a Educação e a Cidadania, Portugal
2010 - 2010 Colaborator in Neurosciences pratical classes integrated in the Master degree in Medicine, University of Coimbra. 2010. Medicina (Mestrado integrado) Universidade de Coimbra, Portugal
2007 - 2008 Supervisor of laboratory rotations for students of the Master in Cell and Molecular Biology, University of Coimbra, Portugal. Laboratory rotations for students of the Master in Cell and Molecular Biology (Mestrado) Universidade de Coimbra, Portugal
2006 - 2006 Supervisor of laboratory rotations for students of the Doctoral Programme in Experimental Biology and Biomedicine, CNC, University of Coimbra. Laboratory rotations for students of the Doctoral Programme in Experimental Biology and Biomedicine (Doutoramento) CNC.IBILI, Portugal

Interview (newspaper / magazine)

Activity description Newspaper / Forum
2019/08/09 Interview related to the manuscript published in Cell Reports. Rui O Costa is the first author and co-correspounding author. Diário as Beiras
2019/08/08 Interview related to the manuscript published in Cell Reports. Rui O Costa is the first author and co-correspounding author. Público
2013/03/28 Interview related to the program "pais com ciência" sponsored by "Ciência viva", in which the program "programa de ciência experimental para o ensino básico" was inserted. The advanced courses in "Cell Physiology and Molecular Biology Course", with the main function of science awareness, were lectured by Rui Costa and Pedro Alves to 48 students and 8 high school teacher during 2 years (2013-2014) at the ESOB (high school at Oliveira do Bairro, Portugal). Diário da Bairrada

Interview (tv / radio show)

Program Topic
2013/06/25 - 2013/06/25 RTP - Notícias. (The portuguese national tv channel). Interview regarding the advanced courses in Cell Physiology and Molecular Biology Course lectured by Rui O Costa and co-conceived by Rui O Costa and IEC (Instituto para a Educação e Cidadania) to high-school 48 students and 8 teachers for 2 years (2013-2014). Cell Physiology and Molecular Biology

Journal scientific committee

Journal title (ISSN) Publisher
2024 - Current Frontiers in Cellular Neuroscience Elsivier

Mentoring / Tutoring

Topic Student name
2023/02 - Current Undergraduate students tutoring. Laboratorial Rotation students ("unidade curricular Projecto (LBIOQ) ). The role of hnRNP H2 in MRXSB. Afonso Lourinho
2017 - Current PhD student tutoring at University of Coimbra, Portugal. "The effect of mesenchymal stem cells secretome on post-injury synapse formations" Diogo Alexandre da Silva Tomé
2025 - 2025 Impact of RNA binding proteins mutations in neuronal development and function Guilherme Galvão
2025 - 2025 The cellular role of hnRNP H2 Luca Wübbenhorst
2025 - 2025 The cellular role of hnRNP H2 Gabriel Pinheiro
2024/06 - 2024/07 The role of hnRNP H2 in epilepsy. Ana Pinto
2023 - 2024 The role of hnRNP H2 in MRXSB Afonso Lourinho
2023 - 2023 The role of hnRNP H2 in HNRNPH2-related Neurodevelopmental Disorder. Gulbenkian Novos Talentos 2023 Awardee. Role: Tutor Afonso Lourinho Pereira Maranhas Alves
2021/10 - 2022/05 The role of BDNF in autophagy Carlos Avilés Granados
2022/03/01 - 2022/03/31 Undergraduate students tutoring. Laboratorial Rotation students ("unidade curricular Projecto (LBIOQ) ). Investigation of the role of BDNF in autophagy modulation of synaptic plasticity João Videira Duarte Henriques
2022/03/01 - 2022/03/31 Undergraduate students tutoring. Laboratorial Rotation students ("unidade curricular Projecto (LBIOQ) ) Investigating the impact of Aß oligomers in the axonal retrograde transport of autophagic structures by JIP1 Rafael de Oliveira Patarra
2021/02/15 - 2021/06 Undergraduate students tutoring. Laboratorial Rotation students ("unidade curricular Projecto (LBIOQ) ) Marta Sofia Santos Silva
2020/08/01 - 2020/10/31 Tutoring in summer course. Alterações nas sinápses GABAérgicas num modelo de epileptogénese in vitro. Giorgio Belperio
2020/03 - 2020/07 Undergraduate students tutoring. Laboratorial Rotation students ("unidade curricular Projecto (LBIOQ) “) Anabela Pereira Tomás
2015/09 - 2019/09 PhD student tutoring at University of Coimbra, Portugal. " Secreted molecules in neuronal development and disease". Luis Filipe Maximino Martins
2018 - 2018 Undergraduate students tutoring. Laboratorial Rotation students ("unidade curricular Projecto (LBIOQ) “) Magda Ferreira Rodrigues
2018 - 2018 Undergraduate students tutoring. Laboratorial Rotation students ("unidade curricular Projecto (LBIOQ) “) Raquel Sofia Inácio Pinto
2016 - 2016 Undergraduate students tutoring. Laboratorial Rotation students ("unidade curricular Projecto (LBIOQ) “) Diogo António Jarró Margato
2016 - 2016 Undergraduate students tutoring. Laboratorial Rotation students ("unidade curricular Projecto (LBIOQ) “) Manuel Morais Jorge Coelho
2012 - 2013 Undergraduate students tutoring. Laboratorial Rotation students ("unidade curricular Projecto (LBIOQ) " Rita Filipe de Almeida Neves
2011 - 2013 Master student tutoring at University of Coimbra, Portugal. "Role of local protein synthesis in presynaptogenesis." Luís Filipe Maximino Martins
2008 - 2009 Master student tutoring at University of Coimbra, Portugal. "Neuroprotection by leptin and grelin against amyloid-beta toxicity in hippocampal neurons. Relevance for therapeutic intervention in Alzheimer's disease." Isaura Vanessa Antunes Martins
2008/04 - 2008/08 Master student tutoring at the university of Coimbra, Portugal. "Role of Mithocondrial Dysfunction on Tau Hyperphosphorylation." Alessandro De Stefano
Distinctions

Award

2024 Best oral communication at "Encontro nacional de epileptologia" (ENE), Coimbra, 2024
Liga Portuguesa Contra a Epilepsia, Portugal
2022 Scientific Incentive Grant 2022 -Portuguese Epilepsy foundation (LPCE)
2022 Scholarship to attend the 8th European Synapse Meeting (ESM) (2022)
2013 Postdoctoral fellowship by FCT (SFRH/BPD/84593/2012)
Fundação para a Ciência e a Tecnologia, Portugal
2007 Travel Grant to attend the 21s Bienal Meeting of the International Society for Neurochemistry
FLAD - Fundação Luso Americana Para o desenvolvimento, Portugal
2007 Travel Grant to attend the 21st Bienal Meeting of the International Society for Neurochemistry
SPB - Sociedade Portuguesa de Bioquímica, Portugal
2006 Full PhD fellowship by FCT (SFRH/BD/28403/2006)
Fundação para a Ciência e a Tecnologia, Portugal

Title

2011 PhD in Biology
Universidade de Coimbra, Portugal

Other distinction

2025 Research grant- "Understanding RNA-Binding Protein hnRNPH2 Mutations: Implications for Synaptic Function and Neurodevelopmental Disorders." Role: Principal Investigator (PI)
Fundação para a Ciência e a Tecnologia, Portugal
2023 Elected PostDoc Representative, Centre for Innovative Biomedicine and Biotechnology (CIBB).
2019 Junior Researcher Position, CNC (Portuguese Foundation for Science and Technology – FCT DL 57/2016/CP1448/CT0009)
Fundação para a Ciência e a Tecnologia, Portugal
2013 Exploratory Research Grant, FCT – "Mechanisms Underlying Ribosomal Regulation in Axonal Development."
Fundação para a Ciência e a Tecnologia, Portugal