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Rui Moreira completed his Master degree at the Faculty of Pharmacy, University of Lisbon, and obtained his PhD under supervision of Professors Eduarda Rosa (University of Lisbon) and Jim Iley (The Open University). After a postdoctoral stay in the UK, Rui started his career as an independent scientist in Lisbon in 1993 and was promoted to Professor of Medicinal Chemistry in 2006, becoming Head of Department in 2010-2016, and Director of the Research Institute for Medicines (iMed.ULisboa) in 2010-2013. Rui has wide research interests in the fields of medicinal chemistry and chemical biology, covering the development of anti-infectious and anticancer agents, prodrug chemistry, structure-reactivity-metabolism relationships, design of covalent inhibitors, and design of chemical probes for activity- and photoaffinity-based protein profiling. He has published over 155 papers and successfully supervised/co-supervised more than 20 PhD students. Rui was co-founder of the Medicinal Chemistry Division of the Portuguese Chemical Society, and as served the European Federation for Medicinal Chemistry (EFMC) as Council member in 2008-2015 and as Executive Committee member since 2015. He is the EFMC President since January 2021.
Identificação

Identificação pessoal

Nome completo
Rui Moreira

Nomes de citação

  • Moreira, Rui

Identificadores de autor

Ciência ID
8B11-E8C0-DFD0
ORCID iD
0000-0003-0727-9852
Researcher Id
G-7485-2011
Scopus Author Id
7102554088

Endereços de correio eletrónico

  • rmoreira@ff.ul.pt (Profissional)

Moradas

  • Faculty of Pharmacy, University of Lisbon, Av. Professor Gama Pinto, 1649-003, Lisboa, Lisboa, Portugal (Profissional)

Websites

  • http://imed.ulisboa.pt/cv/rui-moreira/ (Profissional)

Domínios de atuação

  • Ciências Médicas e da Saúde - Medicina Básica - Química Médica
  • Ciências Exatas - Química - Química Orgânica
  • Ciências Médicas e da Saúde - Ciências da Saúde - Doenças Infeciosas
  • Ciências Médicas e da Saúde - Medicina Básica - Farmacologia e Farmácia

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português (Idioma materno)
Inglês Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Francês Utilizador independente (B1) Utilizador independente (B1) Utilizador independente (B1) Utilizador independente (B1)
Espanhol; Castelhano Utilizador elementar (A1) Utilizador independente (B1) Utilizador elementar (A1) Utilizador elementar (A1)
Formação
Grau Classificação
2004
Concluído
Pharmaceutical Sciences (Título de Agregado)
Especialização em Medicinal Chemistry
Universidade de Lisboa Faculdade de Farmácia, Portugal
1991/06
Concluído
Farmácia (Doutoramento)
Especialização em Pharmaceutical and Medicinal Chemistry
Universidade de Lisboa Faculdade de Farmácia, Portugal
"Contribution to the development of prodrugs for several anticancer agents" (TESE/DISSERTAÇÃO)
1980 - 1985/07
Concluído
Ciências Farmacêuticas (Licenciatura)
Especialização em Industrial Pharmacy
Universidade de Lisboa Faculdade de Farmácia, Portugal
18/20
Percurso profissional

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento
Empregador
2006/10/01 - Atual Professor Catedrático (Docente Universitário) Universidade de Lisboa Faculdade de Farmácia, Portugal
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
(...)
2002/10/01 - 2006/10/31 Professor Associado (Docente Universitário) Universidade de Lisboa Faculdade de Farmácia, Portugal
1991/10/01 - 2002/09/30 Professor Auxiliar (Docente Universitário) Universidade de Lisboa Faculdade de Farmácia, Portugal
Projetos

Bolsa

Designação Financiadores
2018 - 2021/09/30 Tricks or Treats? Toward Selective Organoruthenium(II) Glycoconjugated Anticancer Agents RuGly
PTDC/MED-QUI/31468/2017
Investigador
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal

Universidade Nova de Lisboa, Portugal
Fundação para a Ciência e a Tecnologia
2018 - 2021/09 NPSTEENSBRAIN. New Psychoactive Substances - A Platform for Risk Assessment of Teens Brain Exposure
PTDC/SAU-TOX/32515/2017
Investigador
Fundação para a Ciência e a Tecnologia
2014 - 2015/12 Incentive - UI 4013 - 2014
Provided by PTCRIS: 137395
Investigador responsável
Fundação para a Ciência e a Tecnologia

Projeto

Designação Financiadores
2018 - 2021/09/30 A multitarget strategy to hit all stages of the Plasmodium life-cycle
PTDC/MED-QUI/30021/2017
Investigador responsável
Universidade Nova de Lisboa, Portugal

Instituto de Medicina Molecular João Lobo Antunes, Portugal

Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
Fundação para a Ciência e a Tecnologia
2018 - 2021/08/09 Dialysis membranes by design: targeting neutrophil elastase to reduce inflammation/oxidative stress in end-stage renal disease
PTDC/MEC-CAR/31322/2017
PTDC/MED-CAR/31322/2017
POCI-01-0145-FEDER-031322
POCI-01-0145-FEDER-031322
Investigador
Universidade de Coimbra, Portugal

Universidade do Porto, Portugal

Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
Fundação para a Ciência e a Tecnologia
2018 - 2021/05/31 Fígado Gordo Não-alcoólico: Biomarcardores, Alvos e Terapias Emergentes
PTDC/MED-FAR/29097/2017
Universidade de Lisboa Faculdade de Farmácia, Portugal

Universidade de Lisboa Faculdade de Medicina, Portugal
Fundação para a Ciência e a Tecnologia
2018 - 2021/05/31 Target@TB. Exploring a novel chemical tool to unveil new therapies and molecular targets for tuberculosis
PTDC/MED-FAR/30266/2017
Investigador
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
Fundação para a Ciência e a Tecnologia
2017 - 2020/12/31 PRECISION ONCOLOGY BY INNOVATIVE THERAPIES AND TECHNOLOGIES
SAICTPAC/0019/2015
Universidade de Lisboa Faculdade de Farmácia, Portugal

Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal

INESC Microsistemas e Nanotecnologias, Portugal

Instituto Politécnico de Leiria, Portugal

Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal

Universidade de Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
2016 - 2020/06/30 Small-molecule inhibitors of human proteasome: a step forward in anticancer drug discovery
PTDC/QEQ-MED/7042/2014
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Universidade da Beira Interior, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
2016 - 2019/12/31 Exploring TOR/PI3K kinases as targets for treating protozoan neglected tropical diseases
PTDC/QEQ-MED/7097/2014
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
Fundação para a Ciência e a Tecnologia
2016 - 2019/12/31 ProbeCOPD. Protease activity-based probes for Chronic Obstructive Pulmonary Disease diagnostics
PTDC/BBB-BEP/2463/2014
Associação para a Investigação e Desenvolvimento da Faculdade de Medicina, Portugal
Fundação para a Ciência e a Tecnologia
2016 - 2019/06/30 New Drugs to Treat Non-alcoholic Fatty Liver and Progression to Cancer
PTDC/BIM-MEC/0895/2014
Centro Hospitalar de Lisboa Central EPE, Portugal

Centro Hospitalar Universitário Lisboa Norte EPE, Portugal
Fundação para a Ciência e a Tecnologia
2014 - 2015/10/14 BioClick@LSMal. Bioorthogonal clickable probes to target the liver stage of malaria
EXPL/QEQ-MED/1574/2013
Investigador
Fundação para a Ciência e a Tecnologia
2012 - 2015/08/31 Towards malaria eradication. A novel approach for multi-targeting the parasite´s life cycle
PTDC/SAU-FAR/118459/2010
Universidade de Lisboa Faculdade de Farmácia, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
2013 - 2014/12/25 Exploring a new approach to target KRAS oncogene
EXPL/QEQ-MED/0502/2012
Fundação para a Ciência e a Tecnologia
2011 - 2014/08/31 TARGETING HEMOZOIN CRYSTAL STRUCTURE: A RATIONAL APPROACH TO THE DESIGN OF NOVEL ANTIMALARIALS
PTDC/SAU-FAR/114864/2009
Universidade de Lisboa Faculdade de Farmácia, Portugal

Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
Fundação para a Ciência e a Tecnologia
2010 - 2013/09/30 New drugs for treating and eradicating malaria
HMSP-CT/SAU-ICT/0068/2009
Instituto de Medicina Molecular João Lobo Antunes, Portugal

Fundação Calouste Gulbenkian, Portugal

Universidade de Lisboa Faculdade de Farmácia, Portugal
Fundação para a Ciência e a Tecnologia
2010 - 2013/06/30 Targeting the mitochondrial electron transport chain of malaria parasites: computer-assisted design and synthesis of bc1 complex inhibitors as antimalarial agents
PTDC/SAU-FCF/098734/2008
Universidade de Lisboa Faculdade de Farmácia, Portugal
Fundação para a Ciência e a Tecnologia
2009 - 2011/12/31 Advancing the field of drug delivery - combined targeted treatments against human breast cancer and human leukemia (The OncotargetNanoMed network)
NANO/NMed-AT/0042/2007
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Aveiro, Portugal

Universidade do Minho, Portugal

Universidade de Lisboa Faculdade de Farmácia, Portugal
Fundação para a Ciência e a Tecnologia
2008 - 2011/12/30 Rhodium catalysed C-H bond activation and C-C bond formation in water and bio-compatible solvents - An expeditious way to prepare biologically active heterocycles
PTDC/QUI/66695/2006
Universidade de Lisboa Centro de Química-Física Molecular, Portugal

Universidade de Lisboa Faculdade de Farmácia, Portugal

Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Universidade de Lisboa Instituto Superior Técnico, Portugal

Universidade de Lisboa Faculdade de Farmácia, Portugal
Fundação para a Ciência e a Tecnologia
2007 - 2011/10/31 Chemical reactivity as a tool in drug design: modification of the beta-lactam scaffold to improve serine protease inhibition
PTDC/QUI/64056/2006
Universidade de Lisboa Faculdade de Farmácia, Portugal

Universidade de Lisboa Faculdade de Farmácia, Portugal

Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
Fundação para a Ciência e a Tecnologia
2005 - 2007/09/30 Biochemical characterization and inhibition studies of recombinant cysteine proteases of Plasmodium chabaudi, an animal model for human malaria.
POCI/SAU-ESP/57696/2004
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal

Instituto de Biologia Experimental e Tecnológica, Portugal

Universidade de Lisboa Faculdade de Farmácia, Portugal
Fundação para a Ciência e a Tecnologia
Produções

Publicações

Artigo em revista
  1. Rafael F. A. Gomes; Joao M. J. M. Ravasco; Késsia H. S. Andrade; Jaime A. S. Coelho; Rui Moreira; Rafael Oliveira; Fátima Nogueira; Carlos A. M. Afonso. "Tandem Thio-Michael Addition/Remote Lactone Activation of 5-Hydroxymethylfurfural-Derived d-Lactone-Fused Cyclopentenones". ChemSusChem (2022): https://doi.org/10.1002/cssc.202102204.
    10.1002/cssc.202102204
  2. Solida Long; Denise Duarte; Carla Carvalho; Rafael Oliveira; Nuno Santarém; Andreia Palmeira; Diana I. S. P. Resende; et al. "Indole-Containing Pyrazino[2,1-b]quinazoline-3,6-diones Active against Plasmodium and Trypanosomatids". ACS Medicinal Chemistry Letters (2022): https://doi.org/10.1021/acsmedchemlett.1c00589.
    10.1021/acsmedchemlett.1c00589
  3. Sara R. Oliveira; Pedro A. Dionísio; Maria M. Gaspar; Maria B. T. Ferreira; Catarina A. B. Rodrigues; Rita G. Pereira; Mónica S. Estevão; et al. "Discovery of a Necroptosis Inhibitor Improving Dopaminergic Neuronal Loss after MPTP Exposure in Mice". International Journal of Molecular Sciences 22 10 (2021): 5289-5289. https://doi.org/10.3390/ijms22105289.
    10.3390/ijms22105289
  4. Almeida, A.F.; Ataíde, F.A.P.; Loureiro, R.M.S.; Moreira, R.; Rodrigues, T.. "Augmenting Adaptive Machine Learning with Kinetic Modeling for Reaction Optimization". Journal of Organic Chemistry 86 20 (2021): 14192-14198. http://www.scopus.com/inward/record.url?eid=2-s2.0-85110973936&partnerID=MN8TOARS.
    10.1021/acs.joc.1c01038
  5. Miethke, M.; Pieroni, M.; Weber, T.; Brönstrup, M.; Hammann, P.; Halby, L.; Arimondo, P.B.; et al. "Towards the sustainable discovery and development of new antibiotics". Nature Reviews Chemistry 5 10 (2021): 726-749. http://www.scopus.com/inward/record.url?eid=2-s2.0-85110714419&partnerID=MN8TOARS.
    10.1038/s41570-021-00313-1
  6. Barbosa, M.; Gomes, C.; Sequeira, C.; Gonçalves-Ribeiro, J.; Pina, C.C.; Carvalho, L.A.; Moreira, R.; et al. "Recovery of Depleted miR-146a in ALS Cortical Astrocytes Reverts Cell Aberrancies and Prevents Paracrine Pathogenicity on Microglia and Motor Neurons". Frontiers in Cell and Developmental Biology 9 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85105432735&partnerID=MN8TOARS.
    10.3389/fcell.2021.634355
  7. Gomes-Alves, A.G.; Duarte, M.; Cruz, T.; Castro, H.; Lopes, F.; Moreira, R.; Ressurreição, A.S.; Tomás, A.M.. "Biological evaluation and mechanistic studies of quinolin-(1H)-imines as a new chemotype against leishmaniasis". Antimicrobial Agents and Chemotherapy 65 7 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85108296688&partnerID=MN8TOARS.
    10.1128/AAC.01513-20
  8. André Campaniço; Shrika G. Harjivan; Digby F. Warner; Rui Moreira; Francisca Lopes. "Addressing Latent Tuberculosis: New Advances in Mimicking the Disease, Discovering Key Targets, and Designing Hit Compounds". International Journal of Molecular Sciences 21 22 (2020): 8854-8854. https://doi.org/10.3390/ijms21228854.
    10.3390/ijms21228854
  9. Brito, H.; Marques, V.; Afonso, M.B.; Brown, D.G.; Börjesson, U.; Selmi, N.; Smith, D.M.; et al. "Phenotypic high-throughput screening platform identifies novel chemotypes for necroptosis inhibition". Cell Death Discovery 6 1 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85079729058&partnerID=MN8TOARS.
    10.1038/s41420-020-0240-0
  10. de Mello-Sampayo, C.; Vaz, A.R.; Henriques, S.C.; Fernandes, A.; Paradinha, F.; Florindo, P.; Faria, P.; et al. "Designer Cathinones N-Ethylhexedrone and Buphedrone Show Different In Vitro Neurotoxicity and Mice Behaviour Impairment". Neurotoxicity Research (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85086428280&partnerID=MN8TOARS.
    10.1007/s12640-020-00229-6
  11. Carvalho, L.A.R.; Almeida, V.T.; Brito, J.A.; Lum, K.M.; Oliveira, T.F.; Guedes, R.C.; Gonçalves, L.M.; et al. "3-Oxo-ß-sultam as a Sulfonylating Chemotype for Inhibition of Serine Hydrolases and Activity-Based Protein Profiling". ACS Chemical Biology 15 4 (2020): 878-883. http://www.scopus.com/inward/record.url?eid=2-s2.0-85083620100&partnerID=MN8TOARS.
    10.1021/acschembio.0c00090
  12. Milheiro, S.A.; Gonçalves, J.; Lopes, R.M.R.M.; Madureira, M.; Lobo, L.; Lopes, A.; Nogueira, F.; et al. "Half-Sandwich Cyclopentadienylruthenium(II) Complexes: A New Antimalarial Chemotype". Inorganic Chemistry 59 17 (2020): 12722-12732. http://www.scopus.com/inward/record.url?eid=2-s2.0-85090481236&partnerID=MN8TOARS.
    10.1021/acs.inorgchem.0c01795
  13. Carrola, J.; Duarte, N.; Florindo, P.; Henriques, S.; da Silva, G.; Bijlsma, L.; Moreira, R.; et al. "Metabolism of N-ethylhexedrone and buphedrone: An in vivo study in mice using HPLC-MS/MS". Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences 1159 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85090272900&partnerID=MN8TOARS.
    10.1016/j.jchromb.2020.122340
  14. Cláudia Braga; Ana R. Vaz; M. Conceição Oliveira; M. Matilde Marques; Rui Moreira; Dora Brites; Maria J. Perry. "Targeting gliomas with triazene-based hybrids: Structure-activity relationship, mechanistic study and stability". European Journal of Medicinal Chemistry 172 (2019): 16-25. https://doi.org/10.1016/j.ejmech.2019.03.048.
    10.1016/j.ejmech.2019.03.048
  15. de Almeida, A.F.; Moreira, R.; Rodrigues, T.. "Synthetic organic chemistry driven by artificial intelligence". Nature Reviews Chemistry 3 10 (2019): 589-604. http://www.scopus.com/inward/record.url?eid=2-s2.0-85071226878&partnerID=MN8TOARS.
    10.1038/s41570-019-0124-0
  16. Capela, R.; Moreira, R.; Lopes, F.. "An overview of drug resistance in protozoal diseases". International Journal of Molecular Sciences 20 22 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85075088498&partnerID=MN8TOARS.
    10.3390/ijms20225748
  17. Campaniço, A.; Carrasco, M.P.; Njoroge, M.; Seldon, R.; Chibale, K.; Perdigão, J.; Portugal, I.; et al. "Azaaurones as Potent Antimycobacterial Agents Active against MDR- and XDR-TB". ChemMedChem 14 16 (2019): 1537-1546. http://www.scopus.com/inward/record.url?eid=2-s2.0-85069925921&partnerID=MN8TOARS.
    10.1002/cmdc.201900289
  18. Vaz, A.R.; Pinto, S.; Ezequiel, C.; Cunha, C.; Carvalho, L.A.; Moreira, R.; Brites, D.. "Phenotypic effects of wild-type and mutant SOD1 expression in n9 murine microglia at steady state, inflammatory and immunomodulatory conditions". Frontiers in Cellular Neuroscience 13 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85064224780&partnerID=MN8TOARS.
    10.3389/fncel.2019.00109
  19. Domingos, S.; Duarte, T.; Saraiva, L.; Guedes, R.C.; Moreira, R.. "Targeting leucine-rich repeat kinase 2 (LRRK2) for the treatment of Parkinson's disease". Future Medicinal Chemistry 11 16 (2019): 1953-1977. http://www.scopus.com/inward/record.url?eid=2-s2.0-85072144253&partnerID=MN8TOARS.
    10.4155/fmc-2018-0484
  20. João P. M. António; Lídia M. Gonçalves; Rita C. Guedes; Rui Moreira; Pedro M. P. Gois. "Diazaborines as New Inhibitors of Human Neutrophil Elastase". ACS Omega (2018): https://doi.org/10.1021/acsomega.8b00702.
    10.1021/acsomega.8b00702
  21. Duarte, A.R.; Cadoni, E.; Ressurreição, A.S.; Moreira, R.; Paulo, A.. "Design of Modular G-quadruplex Ligands". ChemMedChem 13 9 (2018): 869-893. http://www.scopus.com/inward/record.url?eid=2-s2.0-85045335649&partnerID=MN8TOARS.
    10.1002/cmdc.201700747
  22. Marto, J.; Ruivo, E.; Lucas, S.D.; Gonçalves, L.M.; Simões, S.; Gouveia, L.F.; Felix, R.; et al. "Starch nanocapsules containing a novel neutrophil elastase inhibitor with improved pharmaceutical performance". European Journal of Pharmaceutics and Biopharmaceutics 127 (2018): 1-11. http://www.scopus.com/inward/record.url?eid=2-s2.0-85041571552&partnerID=MN8TOARS.
    10.1016/j.ejpb.2018.01.011
  23. Campaniço, A.; Moreira, R.; Lopes, F.. "Drug discovery in tuberculosis. New drug targets and antimycobacterial agents". European Journal of Medicinal Chemistry 150 (2018): 525-545. http://www.scopus.com/inward/record.url?eid=2-s2.0-85043527030&partnerID=MN8TOARS.
    10.1016/j.ejmech.2018.03.020
  24. Capela, R.; Magalhães, J.; Miranda, D.; Machado, M.; Sanches-Vaz, M.; Albuquerque, I.S.; Sharma, M.; et al. "Endoperoxide-8-aminoquinoline hybrids as dual-stage antimalarial agents with enhanced metabolic stability". European Journal of Medicinal Chemistry 149 (2018): 69-78. http://www.scopus.com/inward/record.url?eid=2-s2.0-85042651839&partnerID=MN8TOARS.
    10.1016/j.ejmech.2018.02.048
  25. Ribeiro, C.J.A.; Nunes, R.C.; Amaral, J.D.; Gonçalves, L.M.; Rodrigues, C.M.P.; Moreira, R.; Santos, M.M.M.. "Spirotriazoline oxindoles: A novel chemical scaffold with in vitro anticancer properties". European Journal of Medicinal Chemistry 140 (2017): 494-509. http://www.scopus.com/inward/record.url?eid=2-s2.0-85030537870&partnerID=MN8TOARS.
    10.1016/j.ejmech.2017.09.037
  26. Falcão, A.S.; Carvalho, L.A.R.; Lidónio, G.; Vaz, A.R.; Lucas, S.D.; Moreira, R.; Brites, D.. "Dipeptidyl Vinyl Sulfone as a Novel Chemical Tool to Inhibit HMGB1/NLRP3-Inflammasome and Inflamma-miRs in Aß-Mediated Microglial Inflammation". ACS Chemical Neuroscience 8 1 (2017): 89-99. http://www.scopus.com/inward/record.url?eid=2-s2.0-85013640037&partnerID=MN8TOARS.
    10.1021/acschemneuro.6b00250
  27. Pinheiro, R.; Braga, C.; Santos, G.; Bronze, M.R.; Perry, M.J.; Moreira, R.; Brites, D.; Falcão, A.S.. "Targeting Gliomas: Can a New Alkylating Hybrid Compound Make a Difference?". ACS Chemical Neuroscience 8 1 (2017): 50-59. http://www.scopus.com/inward/record.url?eid=2-s2.0-85013797326&partnerID=MN8TOARS.
    10.1021/acschemneuro.6b00169
  28. Carrasco, M.P.; Machado, M.; Gonçalves, L.; Sharma, M.; Gut, J.; Lukens, A.K.; Wirth, D.F.; et al. "Probing the Azaaurone Scaffold against the Hepatic and Erythrocytic Stages of Malaria Parasites". ChemMedChem (2016): 2194-2204. http://www.scopus.com/inward/record.url?eid=2-s2.0-84989959759&partnerID=MN8TOARS.
    10.1002/cmdc.201600327
  29. Sousa, M.E.; Araújo, M.J.; Do Vale, M.L.; Andrade, P.B.; Branco, P.; Gomes, P.; Moreira, R.; Pinho E Melo, T.M.V.D.; Freitas, V.. "11thnational meeting of organic chemistry and 4th meeting of therapeutic chemistry". Pharmaceuticals 9 1 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84977567343&partnerID=MN8TOARS.
    10.3390/ph9010015
  30. Ribeiro, C.J.A.; Amaral, J.D.; Rodrigues, C.M.P.; Moreira, R.; Santos, M.M.M.. "Spirooxadiazoline oxindoles with promising in vitro antitumor activities". MedChemComm 7 3 (2016): 420-425. http://www.scopus.com/inward/record.url?eid=2-s2.0-84961801651&partnerID=MN8TOARS.
    10.1039/c5md00450k
  31. Ribeiro, C.J.A.; Espadinha, M.; Machado, M.; Gut, J.; Gonçalves, L.M.; Rosenthal, P.J.; Prudêncio, M.; Moreira, R.; Santos, M.M.M.. "Novel squaramides with in vitro liver stage antiplasmodial activity". Bioorganic and Medicinal Chemistry 24 8 (2016): 1786-1792. http://www.scopus.com/inward/record.url?eid=2-s2.0-84960971045&partnerID=MN8TOARS.
    10.1016/j.bmc.2016.03.005
  32. Ruivo, E.F.P.; Gonçalves, L.M.; Carvalho, L.A.R.; Guedes, R.C.; Hofbauer, S.; Brito, J.A.; Archer, M.; Moreira, R.; Lucas, S.D.. "Clickable 4-Oxo-ß-lactam-Based Selective Probing for Human Neutrophil Elastase Related Proteomes". ChemMedChem (2016): 2037-2042. http://www.scopus.com/inward/record.url?eid=2-s2.0-84988410118&partnerID=MN8TOARS.
    10.1002/cmdc.201600258
  33. Ribeiro, C.J.A.; Rodrigues, C.M.P.; Moreira, R.; Santos, M.M.M.. "Chemical variations on the p53 reactivation theme". Pharmaceuticals 9 2 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84973316044&partnerID=MN8TOARS.
    10.3390/ph9020025
  34. Lavrado, J.; Ohnmacht, S.A.; Correia, I.; Leitão, C.; Pisco, S.; Gunaratnam, M.; Moreira, R.; et al. "Indolo[3,2-c]quinoline G-quadruplex stabilizers: A structural analysis of binding to the human telomeric G-quadruplex". ChemMedChem 10 5 (2015): 836-849. http://www.scopus.com/inward/record.url?eid=2-s2.0-84928492026&partnerID=MN8TOARS.
    10.1002/cmdc.201500067
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    10.1016/S0960-894X(01)00131-7
  146. Iley, J.; Lopes, F.; Moreira, R.. "Kinetics and mechanism of hydrolysis of N-amidomethylsulfonamides". Journal of the Chemical Society, Perkin Transactions 2 5 (2001): 749-753. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035528977&partnerID=MN8TOARS.
  147. Iley, J.; Barroso, H.; Moreira, R.; Lopes, F.; Calheiros, T.. "Acyloxymethyl as a drug protecting group. Part 7: Tertiary sulfonamidomethyl ester prodrugs of benzylpenicillin: Chemical hydrolysis and anti-bacterial activity". Bioorganic and Medicinal Chemistry 8 7 (2000): 1629-1636. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033936572&partnerID=MN8TOARS.
    10.1016/S0968-0896(00)00099-7
  148. Lopes, F.; Moreira, R.; Iley, J.. "Acyloxymethyl as a drug protecting group. Part 6: N-acyloxymethyl- and N-[(aminocarbonyloxy)methyl]sulfonamides as prodrugs of agents containing a secondary sulfonamide group". Bioorganic and Medicinal Chemistry 8 4 (2000): 707-716. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034027024&partnerID=MN8TOARS.
    10.1016/S0968-0896(00)00015-8
  149. Lopes, F.; Moreira, R.; Iley, J.. "Acyloxymethyl as a drug protecting group. Part 5. Kinetics and mechanism of the hydrolysis of tertiary N-acyloxymethylsulfonamides". Journal of the Chemical Society. Perkin Transactions 2 3 (1999): 431-439. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037889702&partnerID=MN8TOARS.
  150. Iley, J.; Mendes, E.; Moreira, R.; Souza, S.. "Cleavage of tertiary amidomethyl ester prodrugs of carboxylic acids by rat liver homogenates". European Journal of Pharmaceutical Sciences 9 2 (1999): 201-205. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033460252&partnerID=MN8TOARS.
    10.1016/S0928-0987(99)00057-3
  151. Portela, M.J.; Moreira, R.; Valente, E.; Constantino, L.; Iley, J.; Pinto, J.; Rosa, R.; Cravo, P.; Do Rosario, V.E.. "Dipeptide derivatives of primaquine as transmission-blocking antimalarials: Effect of aliphatic side-chain acylation on the gametocytocidal activity and on the formation of carboxyprimaquine in rat liver homogenates". Pharmaceutical Research 16 6 (1999): 949-955. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033020951&partnerID=MN8TOARS.
    10.1023/A:1018922425551
  152. Constantino, L.; Paixão, P.; Moreira, R.; Portela, M.J.; Do Rosario, V.E.; Iley, J.. "Metabolism of primaquine by liver homogenate fractions. Evidence for monoamine oxidase and cytochrome P450 involvement in the oxidative deamination of primaquine to carboxyprimaquine". Experimental and Toxicologic Pathology 51 4-5 (1999): 299-303. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032781772&partnerID=MN8TOARS.
    10.1016/S0940-2993(99)80010-4
  153. Iley, J.; Calheiros, T.; Moreira, R.. "Phthalimidomethyl as a drug pro-moiety. Probing its reactivity". Bioorganic and Medicinal Chemistry Letters 8 8 (1998): 955-958. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032554692&partnerID=MN8TOARS.
    10.1016/S0960-894X(98)00135-8
  154. Iley, J.; Moreira, R.; Calheiros, T.; Mendes, E.. "Acyloxymethyl as a drug protecting group: Part 4. The hydrolysis of tertiary amidomethyl-ester prodrugs of carboxylic acid agents". Pharmaceutical Research 14 11 (1997): 1634-1639. http://www.scopus.com/inward/record.url?eid=2-s2.0-6844261184&partnerID=MN8TOARS.
    10.1023/A:1012146905833
  155. Moreira, R.; Calheiros, T.; Cabrita, J.; Mendes, E.; Pimentel, M.; Iley, J.. "Acyloxymethyl as a drug protecting group. Part 3. Tertiary O-amidomethyl esters of penicillin G: Chemical hydrolysis and anti-bacterial activity". Pharmaceutical Research 13 1 (1996): 70-75. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029865020&partnerID=MN8TOARS.
    10.1023/A:1016077200460
  156. Calheiros, T.; Iley, J.; Lopes, F.; Moreira, R.. "Acyloxymethyl as a drug protecting group. Synthesis and reactivity of N-acyloxymethylsulfonamide prodrugs". Bioorganic and Medicinal Chemistry Letters 5 9 (1995): 937-940. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029063007&partnerID=MN8TOARS.
    10.1016/0960-894X(95)00146-K
  157. Moreira, R.; Mendes, E.; Calheiros, T.; Bacelo, M.J.; Iley, J.. "A new direct synthesis of tertiary N-acyloxymethylamide prodrugs of carboxylic acid drugs". Tetrahedron Letters 35 38 (1994): 7107-7110. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027971217&partnerID=MN8TOARS.
    10.1016/0040-4039(94)88238-X
  158. Rosa, E.; Carvalho, E.; Cheng, S.C.; Fernandes, L.; Iley, J.; Moreira, R.; Nunes, A.; Ruecroft, G.. "Antitumoral triazenes: Biological action and development of prodrugs,TRIAZENOS ANTITUMORAIS: MECANISMO DE ACCAO BIOLOGICA E DESENVOLVIMENTO DE PRO-FARMACOS". Revista Portuguesa de Farmacia 42 3 (1992): 7-14. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026478874&partnerID=MN8TOARS.
  159. Iley, J.; Moreira, R.; Rosa, E.. "Acyloxymethyl as a drug protecting group. Kinetics and mechanism of the hydrolysis of N-acyloxymethylbenzamides". Journal of the Chemical Society, Perkin Transactions 2 5 (1991): 563-570. http://www.scopus.com/inward/record.url?eid=2-s2.0-37049084026&partnerID=MN8TOARS.
  160. Iley, J.; Moreira, R.; Rosa, E.. "Triazene drug metabolites. Part 10. Metal-ion catalysed decomposition of monoalkyltriazenes in ethanol solutions". Journal of the Chemical Society, Perkin Transactions 2 1 (1991): 81-86. http://www.scopus.com/inward/record.url?eid=2-s2.0-0005191632&partnerID=MN8TOARS.
  161. Iley, J.; Moreira, R.; Rosa, E.. "Triazene drug metabolites. Part 11. Synthesis of S-cysteinyl and related derivatives of N-hydroxymethyltriazenes". Journal of the Chemical Society, Perkin Transactions 1 12 (1991): 3241-3244. http://www.scopus.com/inward/record.url?eid=2-s2.0-37049078261&partnerID=MN8TOARS.
  162. Iley, J.; Moreira, R.; Ruecroft, G.; Rosa, E.. "Synthesis of S-cysteinyl, S(N-acetylcysteinyl) and S-glutathionyl conjugates op N-hydroxymethyltriazenes". Tetrahedron Letters 29 22 (1988): 2707-2710. http://www.scopus.com/inward/record.url?eid=2-s2.0-45549120308&partnerID=MN8TOARS.
    10.1016/0040-4039(88)85266-3
  163. Iley, J.N.; Moreira, R.; Rosa, E.. "Triazene drug metabolites. Part 4. Kinetics and mechanism of the decomposition of 1-aryl-3-benzoyloxymethyl-3-methyltriazenes in mixed aqueous-organic solvents". Journal of the Chemical Society, Perkin Transactions 2 10 (1987): 1503-1508. http://www.scopus.com/inward/record.url?eid=2-s2.0-37049081323&partnerID=MN8TOARS.
Capítulo de livro
  1. da Silva, G.; Moreira, R.; Silva, A.M.S.. "Bioactive Quinolactacins and Structurally Related Pyrroloquinolones". 433-453. 2019.
    10.1016/B978-0-444-64185-4.00012-5
  2. Moreira, Rui; Dias, A. F.; Ressurreição, Ana Sofia. "One-Step Synthesis of 4(3H)-Quinazolinones: An Important Heterocyclic Scaffold in Medicinal Chemistry". In Comprehensive Organic Chemistry Experiments for the Laboratory Classroom. The Royal Society of Chemistry, 2016.
    Publicado
  3. Moreira, Rui; Lavrado, J.; Figueiras, M.; Pereira, D. M.; Santos, S. A.; Paulo, Alexandra. "Synthesis of Indolo[3,2-b]quinolin-11-one by Acid-Catalysed Intramolecular Double Cyclization". In Comprehensive Organic Chemistry Experiments for the Laboratory Classroom. The Royal Society of Chemistry, 2016.
    Publicado
  4. Moreira, Rui; Ribeiro, C.J.A.; Santos, M.M.M.. "Synthesis of a spiroisoxazoline oxindole by 1,3-dipolar Cycloaddition". In Comprehensive Organic Chemistry Experiments for the Laboratory Classroom. The Royal Society of Chemistry, 2016.
    Publicado
  5. Moreira, Rui; Lucas, S.D.; Ruivo, E.F.P.; Figueiras, M.; Lavrado, J.. "Click Chemistry". In Comprehensive Organic Chemistry Experiments for the Laboratory Classroom. The Royal Society of Chemistry, 2016.
    Publicado
  6. Lopes, F.; Santos, M.M.M.; Moreira, R.. "Designing covalent inhibitors: A medicinal chemistry challenge". In Biomedical Chemistry: Current Trends and Developments, editado por Vale, Nuno. 2015.
    10.1515/9783110468755-002
  7. Sitoe, A.R.; Lopes, Francisca; Moreira, Rui; Varela Coelho, Ana; Bronze, Maria. "Contribution of Mass Spectrometry to the Study of Antimalarial Agents". In Tandem Mass Spectrometry-Molecular Characterization, editado por Varela Coelho, Ana. Polónia: IntechOpen, 2013.
    Publicado
  8. Mulchande, Jalmira; Lopes, Francisca; Moreira, Rui. "Azetidin-2-ones and related systems as enzyme inhibitors: synthesis and reactivity". In Heterocyclic Targets in Advanced Organic Synthesis, editado por Carreiras, Maria do Carmo; Marco-Contelles, J.. Research Signpost, 2011.
    Publicado
  9. Lavrado, J.; Moreira, Rui; Paulo, Alexandra. "Synthetic strategies towards bioactive indolo[3,2-b]quinolines". In Heterocyclic Targets in Advanced Organic Synthesis, editado por Carreiras, Maria do Carmo; Marco-Contelles, J.. Research Signpost, 2011.
    Publicado
  10. Francisco, A.P.; Perry, M.D.J.; Moreira, R.; Mendes, E.. "Alkylating Agents". In Anticancer Therapeutics. Chichester, Reino Unido: Wiley-Blackwell, 2008.
    10.1002/9780470697047.ch9

Propriedade Intelectual

Pedido provisório de patente
  1. 2021. "1,2,4,5-TETRAOXANE COMPOUNDS, A DRUG DELIVERY SYSTEM BASED IN SAID COMPOUNDS USEFUL IN DIAGNOSES AND THERAPY, AND METHODS THEREOF".
    Protegido

Outros

Outra produção
  1. Milheiro, S.A.; Gonçalves, J.; Lopes, R.; Madureira, M.; Lobo, L.; Lopes, A.; Nogueira, F.; et al. 2020. Half-sandwich cyclopentadienylruthenium(II) complexes: A new antimalarial chemotype. http://www.scopus.com/inward/record.url?eid=2-s2.0-85098906570&partnerID=MN8TOARS.
    10.26434/chemrxiv.12155178.v1
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2020/05/05 Discovery of Dipeptidyl Peptidases 8 and 9 covalent inhibitors using activity-based protein profiling and structure-based drug design António V. Xavier (AVX) seminars
ITQB-NOVA (Oeiras, Portugal)
2019/12 Discovery of new DPP8 and DPP9 inhibitors via activity-based protein profiling of serine hydrolases 4th Iberoamerican Symposium on Organic Chemistry (Sibeaqo-IV)
(Cayo Santa Maria, Cuba)
2019/10 Targeting Serine Hydrolases With Novel Activity-Based Probes University Seminar
University of Gottingen (Gottingen , Alemanha)
2019/01 Target identification using chemical biology Chemistry & Biology CrossTalks
University of Lisbon (Lisboa, Portugal)
2018/03 Boron in Medicinal Chemistry and Chemical Biology 245th American Chemical Society National Meeting
American Chemical Society (New Orleans, Estados Unidos)
2017/12 Novel chemical approaches to target malaria parasites Seminar
University of Bonn (Bonn, Alemanha)
2017/11 Lead discovery for parasitic diseases 3rd Northern Postgraduate Symposium on Chemistry and Biotechnology
Postgraduate Programme on Chemistry and Biotechnology, Federal University of Alagoas (Maceió)
2017/09 From enzyme inhibitors to chemical probes: where Medicinal Chemistry and Chemical Biology meet Seminar
University of Porto (Porto, Portugal)
2017/07 Lead discovery for infectious diseases of the developing world: chemistry to unravel a black box 25th Meeting of the Portuguese Chemical Society
Portuguese Chemical Society (Lisboa, Portugal)
2017/06 Lead discovery for parasitic diseases 2nd Frontiers in Medicinal Chemistry Course
MedChemTrain PhD Programme (Penela, Portugal)
2016/11 Identification and optimization of a novel chemotype with antileishmanial and dual-stage antimalarial activities Drug Discovery and Development Centre (H3D) 2016 Symposium
Drug Discovery and Development Centre (H3D) 2016 Symposium (Worcester, África do Sul)
2015/06 Fine Tuning of Heterocycles to Discover Chemical Tools for Tropical Diseases 7th Spanish-Portuguese-Japanese Organic Chemistry Symposium
Spanish Chemical Society (Seville, Espanha)
2015/06 Drug design and screening: identifying new therapeutic targets 6th European Conference on Chemistry for Life Sciences, Protein School
EuChems Division of Life Sciences (Monte da Caparinca, Portugal)
2015/04 New medicines for malaria elimination 3rd National Meeting on Tropical Medicine
Portuguese Institute of Hygiene and Tropical Medicine (Lisboa, Portugal)
2015/02 Structural optimization of multi-stage acting endoperoxide-based hybrid antimalarials Sam Higginbottom Memorial International Lecture
Sam Higginbottom Institute of Agriculture, Technology and Science (Allahabad, Índia)
2015/02 A Chemogenomic Insight into the Discovery of Single and Dual-Stage Antimalarials 21st Indian Society of Chemists and Biologists International Conference (ISCBC-2015)
Indian Society of Chemists and Biologists (Lucknow, Índia)
2014/11 Chemogenomic Approaches to Single- and Dual-Stage Antimalarial Agents 7th Brazilian Symposium on Medicinal Chemistry (BrazMedChem2014)
(Campos do Jordão, Brasil)
2014/10 Structural optimization of multi-stage acting endoperoxide-based hybrid antimalarials Targeted Chemotherapy towards Diseases Caused by Endoparasites: COST meeting
Targeted Chemotherapy towards Diseases Caused by Endoparasites: COST action (Calvi, França)
2014/06 From Chemical Tools to Pre-Clinical Drug Discovery ChemULisboa
University of Lisbon (Lisboa, Portugal)
2014/05 Integrated Chemogenomic and In Silico Approaches to Develop Novel Antimalarial Lead Compounds Seminar
Institute of Molecular Medicine (Lis, Portugal)
2014/04 In Silico Discovery of Human Neutrophil Elastase Inhibitors for the Treatment of COPD 7th National Meeting of Biochemistry Students
(Monte da Caparica, Portugal)
2013/09 New Chemical Tools to Study the Biology of Malaria 10th National Meeting on Organic Chemistry
Portuguese Chemical Society Division of Organic Chemistry (Lisboa, Portugal)
2013/06 Targeting the liver and blood stages of malaria parasites with small and not-so-small molecules Seminar
University of California San Francisco, San Francisco General Hospital (San Francisco, Estados Unidos)
2013/04 Chemistry in the Treatment of Malaria: From Bench to Bed Seminar
NOVA University, Faculty of Sciences and Technology (Monte da Caparinca, Portugal)
2012/05 Medicinal Chemistry for New Antimalarial Agents ChemForum IST
Instituto Superior Tecnico, Technical University of Lisbon (Lisboa, Portugal)
2012/02 Novel Lead Compounds as Candidates for Single- and Multi-Stage Antimalarial Therapy Seminar
ETH Zurich (Zurich, Suiça)
2011/11 The Pathway From Natural Products to Antimalarials 19th Portuguese-Galician Meeting of Chemistry
Colegio de Quimicos de Galicia and Portuguese Chemical Society (Pontevedra, Espanha)
2011/06 Tuning the Reactivity of the beta-Lactam Scaffold as a Tool To Improve Inhibitory Potency Against Human Neutrophil Elastase 2nd Iberic Meeting on Medicinal Chemistry
(Porto, Portugal)
2011/06 Multi-target Strategies to Treat Malaria: a Challenging Task Seminar
University of Porto, Faculty of Sciences (Porto, Portugal)
2010/10 Rational Design of Bioactive Molecules: From the PC to the Bench and Vice-Versa. Novel Antimalarials Biopharmac 2010
University of Madeira (Funchal, Portugal)
2010/09 From ß-Lactams to 4-Oxo-ß-Lactams: Mechanistic Studies Towards Protease Inhibition 2nd Iberoamerican Symposium on Organic Chemistry (Sibeaqo-II)
(Santiago de Compostela, Espanha)
2010/06 Malaria: the Long Pathway From Concepts to Drugs Seminar
University of Lisbon, Faculty of Sciences (Lisboa, Portugal)
2010/05 Targeting Exoerythrocytic, Erythrocytic and Sexual Stages of Malaria Parasites: a Challenging Task Annual International Conference of Medichem-2010 (ICM-2010)
(Beijing)
2009/06 New strategies in malaria chemotherapy: from recycling antimalarials to structure-base drug design Seminar
University of Evora (Lisboa, Portugal)
2008/12 Design and Synthesis of Human Leukocyte Elastase Inhibitors Based on the ß-Lactam Scaffold Seminar
University of Bonn (Bonn, Alemanha)
2006/12 Perspectivas de Desenvolvimento de Novos Fármacos para a Terapêutica da Malária VI Congresso Luso-Moçambicano de Medicina
2006/02 Recycling Antimalarials New 8-Amino- and 4-Aminoquinoline Analogues GSK Malaria Conference
GlaxoSmithKline (GSK) (Tres Cantos, Madrid, Espanha)
2003/10 Lead Discovery Based on Reactivity Concepts COST Action D13 Conference on New Molecules Towards Human Health Care
COST Action D13 Conference on New Molecules Towards Human Health Care (Li, Portugal)
2003/02 Acyloxymethylation in drug and prodrug design. Scope and limitations Seminar
NOVA University, Faculty of Sciences and Technology (Monte da Caparinca, Portugal)

Orientação

Título / Tema
Papel desempenhado
Curso (Tipo)
Instituição / Organização
2021 - 2025 Targeting glioblastoma with two-photon-activable triazene prodrugs
Orientador
Medicinal Chemistry (Doutoramento)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2021 - 2025 Extending the Akt-targeting pharmacological toolbox with PROteolysis TArgeting Chimeric molecules (PROTACs)
Orientador
Medicinal Chemistry (Doutoramento)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2021 - 2025 Molecular photoswitches for targeting VEGFR2 and control angiogenesis
Orientador
Medicinal Chemistry (Doutoramento)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2018 - 2022 Tetraoxane-based tumor-activated prodrug strategy to target intracellular labile ferrous iron
Orientador
Medicinal Chemistry (Doutoramento)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2018 - 2022 Development of new drug leads for tuberculosis
Coorientador
Medicinal Chemistry (Doutoramento)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2018 - 2022 Expanding the Toolbox of Four-Membered Rings to Study Bacterial Serine Hydrolases
Orientador
Medicinal Chemistry (Doutoramento)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2018 - 2022 Optimizing chemistry in flow with artificial intelligence
Coorientador
Medicinal Chemistry (Doutoramento)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2017 - 2021 Bio-triggered triazenes: a novel approach to release alkylating agents
Orientador
Medicinal Chemistry (Doutoramento)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2017 - 2021 Computational analysis, de novo design, validation and target identification of necroptosis inhibitors
Coorientador
Medicinal Chemistry (Doutoramento)
Universidade de Coimbra Departamento de Química, Portugal
2016 - 2020 Exploring TOR/PI3K kinases as targets for treating protozoan neglected tropical diseases
Coorientador
Medicinal Chemistry (Doutoramento)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2016 - 2020 Pharmacological Modulators of Parkinson’s Disease-Associated Proteins
Orientador
Medicinal Chemistry (Doutoramento)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2015 - 2020 Discovery of novel quinolone-based antimalarials using the Winterfeldt chemistry
Orientador
Medicina Chemistry (Doutoramento)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2015 - 2019 3-Oxo-ß-Sultams and 4-Oxo-ß-Lactams as Chemical Tools for Activity-based Protein Profiling of Serine Hydrolases
Orientador de Luís Carvalho
Universidade de Lisboa Faculdade de Farmácia, Portugal
2012/09/01 - 2017 Medicinal Chemistry Approaches for Novel DNA Ligands
Orientador
Universidade de Lisboa Faculdade de Farmácia, Portugal
2012 - 2016 Medicinal Chemistry Approaches to Malarial Drug Discovery
Coorientador
Universidade de Lisboa Faculdade de Farmácia, Portugal
2011 - 2015 Design and Synthesis of Small Molecule Modulators of p53
Coorientador
Medicinal Chemistry (Doutoramento)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2010 - 2015 Identification and Characterization by Electronspray Mass Spectrometry of Antimalarials that Inhibit the Mitochondrial Electron Transport Chain
Orientador
Universidade de Lisboa Faculdade de Farmácia, Portugal
2010 - 2014 Synthesis and Computer-Assisted Design of Mitochondrial Electron Transport-Chain Inhibitors as Antimalarial Agents
Orientador
Medicinal Chemistry (Doutoramento)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2010 - 2014 Peroxide-Based Hybrid and Prodrug Antimalarials to Deliver Cysteine Protease Inhibitors Into The Parasitic Food Vacuole
Coorientador
Universidade de Lisboa Faculdade de Farmácia, Portugal
2008 - 2012 Design, Synthesis, and Evaluation of Peptidyl Inhibitors for Clan CA and Clan CD Cysteine Proteases
Orientador
Universidade de Lisboa Faculdade de Farmácia, Portugal
2007 - 2011 Compostos híbridos da artemisinina. Direccionamento para as fases sanguínea e hepática do parasita da malária
Coorientador
Universidade de Lisboa Faculdade de Farmácia, Portugal
2006 - 2010 Amino Derivatives of Cryptolepine. Synthesis and In Vitro Studies with DNA and Haeme
Orientador
Universidade de Lisboa Faculdade de Farmácia, Portugal
2004 - 2010 N-Alkyl-ß-Lactams as Irreversible Inhibitors of Serine Proteases
Orientador
Universidade de Lisboa Faculdade de Farmácia, Portugal
2005 - 2009 Irreversible Inhibitors of Serine Proteases Based on the beta-Lactam Scaffold as Potential Drug Candidates
Orientador
Universidade de Lisboa Faculdade de Farmácia, Portugal
2003 - 2007 Potential Irreversible Inhibitors of Cysteine Proteases Based on Sultam and Naphthoquinone Scaffolds
Orientador
Universidade de Lisboa Faculdade de Farmácia, Portugal
2002 - 2007 Bsmoc Derivatives as Potential Cysteine Protease Inhibitors
Orientador
Universidade de Lisboa Faculdade de Farmácia, Portugal
2001 - 2006 Ensaios de Degradação Acelerada do Nimesulide. 4-Imidazolidinonas Como Possíveis Pró-Fármacos da Primaquina
Orientador
Pharmaceutical Chemistry (Doutoramento)
Universidade de Lisboa Faculdade de Farmácia, Portugal
1995 - 2000 Potenciais Pró-Fármacos de Sulfonamidas
Orientador
Pharmaceutical Chemistry (Doutoramento)
Universidade de Lisboa Faculdade de Farmácia, Portugal
1992 - 1997 Desenvolvimento de Potenciais Pró-Fármacos de Ácidos Carboxílicos
Orientador
Pharmaceutical Chemistry (Doutoramento)
Universidade de Lisboa Faculdade de Farmácia, Portugal
1992 - 1997 Reactividade de Ésteres Carboxamido-, Sulfonamido, e Imidometilicos de Penicilinas
Orientador
Pharmaceutical Chemistry (Doutoramento)
Universidade de Lisboa Faculdade de Farmácia, Portugal

Arbitragem científica em conferência

Nome da conferência Local da conferência
2015/01 - 2016/09 International Symposium on Medicinal Chemistry EFMC-ISMC2016 European Federation for Medicinal Chemistry
2013/01 - 2014/09 International Symposium on Medicinal Chemistry EFMC-ISMC2014 European Federation for Medicinal Chemistry
2011/12 - 2012/09 International Symposium on Medicinal Chemistry EFMC-ISMC2012 European Federation for Medicinal Chemistry

Arbitragem científica em revista

Nome da revista (ISSN) Editora
2018 - 2020 MedChemComm (2040-2511) The Royal Society of Chemistry

Membro de associação

Nome da associação Tipo de participação
2008 - Atual American Chemical Society
2000 - Atual Ordem dos Farmacêuticos (Portuguese Board of Pharmacists)
1982/01/18 - Atual Portuguese Chemical Society

Membro de comissão

Descrição da atividade
Tipo de participação
Instituição / Organização
2018/11/01 - Atual Research Foundation Flanders (FWO): chair of the expert panel for pharmaceutical sciences
Outro
Fonds Wetenschappelijk Onderzoek Vlaanderen, Bélgica
2000 - Atual EMA: Expert in regulatory affairs for drug substances
Outro
European Medicines Agency, Reino Unido
1998 - Atual INFARMED: Expert in regulatory affairs for drug substances
Outro
Infarmed Autoridade Nacional do Medicamento e Produtos de Saúde IP, Portugal
2021/01/01 - 2023/12/31 European Federation for Medicinal Chemistry and Chemical Biology (EFMC): President
Presidente / Vice-presidente
European Federation for Medicinal Chemistry, Bélgica
2020/01/01 - 2020/12/31 European Federation for Medicinal Chemistry (EFMC): President Elect
Presidente / Vice-presidente
European Federation for Medicinal Chemistry, Bélgica
2016/01/01 - 2019/12/31 European Federation for Medicinal Chemistry (EFMC): member of the Executive Committee
Membro
European Federation for Medicinal Chemistry, Bélgica
Distinções

Prémio

2009 Luso-American Collaborative Response Awards
Fundação Luso-Americana, Portugal
1985 Sociedade Lusitana Award
Ordem dos Farmaceuticos, Portugal

Título

2015 Honorary Life Fellow, Indian Society of Chemists and Biologists
Indian Society of Chemists and Biologists, Índia

Outra distinção

2014 Chair of the International Simposium on Medicinal Chemistry (EFMC ISMC) 2014