Leonor Cancela (8917-3248-BC8E)

Curriculum Vitae

Leonor Cancela

Leonor Cancela /LC is Full Professor at the Faculty of Medicine and Biomedical Sciences of the University of Algarve/UALG, member of the Algarve Biomedical Centre and founding member of the Centre for Marine Sciences /CCMAR. - She developed her undergraduate/graduate studies at University Paris VI- Pierre et Marie Curie and her PhD work at INSERM/ Hospital Lariboisière, in Paris where she was awarded her PhD in 1985 with honors. She was hired as a postdoctoral researcher by the Univ. of California between Jan 1986-Jan 1988 at the UC Riverside campus and between Feb1988- Nov1992 at the UC San Diego campus. She obtained a position at UALG in Dec1992 and became full professor in 2006. - She was elected President of the Portuguese Biochemical Society between 2005-2008 and is member of the board of the Portuguese Society of Genetics since 2010, elected as President in January 2020 to present. - She is Director of the Bachelor and PhD programs in Biomedical Sciences of the UALG since their implementation, Director of the UALG Doctoral College by rector nomination since 2019 and held several academic positions including director of the Department of Biomedical Sciences and Medicine and President of the Pedagogic and Scientific councils for several terms. - - She is currently President of the Scientific Council of the newly created Faculty of Medicine and Biomedical Sciences of the University of Algarve. - She implemented in 1994 the BIOSKEL research laboratory that she leads since then (http://bioskel.ccmar.ualg.pt) and has coordinated over 150 undergraduate, PhDs and postdoctoral fellows, published over 200 articles in international journals, 15 book chapters, and is co-author of 7 patents and 3 registered marks. - She has implemented in 2008 the Lab.it project to provide hands-on training in molecular biology to high school students and teachers and contribute to disseminate information on the use of molecular tools to different society applications. - She is the co-founder of Technozeb, a Business Unit of Technophage SA involved in the discovery of molecules with therapeutic interest using zebrafish. - She is regularly invited to give seminars and integrate academic juris and evaluation panels in national/international institutions and agencies, including chair of ERC committees. - Research interests focus in molecular, environmental and epigenetic determinants of skeletogenesis in health and disease and the use of zebrafish as model for human pathologies with skeletal phenotypes. - LC participated in the development of several in vitro cell systems and in vivo assays that were used to uncover cellular and molecular mechanisms of bone formation and regeneration but also bone matrix mineralization in zebrafish and farmed fish. Recently these tools are being applied to the screening of natural extracts (e.g. from seaweeds and microalgae) and compound libraries to discover molecules that could serve as the next generation therapeutics against human pathologies including rare diseases such as the Keutel or the CDKL5 syndromes, and skeletal disorders such as osteoporosis and Paget's Disease of bone.

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Identificação

Identificação pessoal

Nome completo: Leonor Cancela

Nomes de citação

ML Cancela
L Cancela
M Leonor Cancela
Leonor Cancela

Identificadores de autor

Ciência ID: 8917-3248-BC8E
ORCID iD: 0000-0003-3114-6662

Endereços de correio eletrónico

lcancela@ualg.pt (Profissional)
leocancela@gmail.com (Profissional)

Telefones

Telefone

289800971 (Profissional)

Telemóvel

916708275 (Pessoal)

Moradas

Universidade do Algarve , Dept de Ciências Biomédicas e Medicina, Campus de Gambelas, 8005-139, Faro, Faro, Portugal (Profissional)

Websites

http://bioskel.ccmar.ualg.pt (Profissional)

Domínios de atuação

Ciências Naturais - Ciências Biológicas
Ciências Médicas e da Saúde - Biotecnologia Médica - Tecnologias que envolvem a Manipulação de Células,Tecidos,Órgãos ou todo o Organismo
Ciências Médicas e da Saúde - Medicina Básica - Genética Humana

Idiomas

Idioma	Conversação	Leitura	Escrita	Compreensão
Inglês	Utilizador proficiente (C1)	Utilizador proficiente (C1)	Utilizador proficiente (C1)	Utilizador proficiente (C1)
Francês	Utilizador proficiente (C1)	Utilizador proficiente (C1)	Utilizador proficiente (C1)	Utilizador proficiente (C1)
Português (Idioma materno)
Espanhol; Castelhano	Utilizador elementar (A1)	Utilizador independente (B1)	Utilizador elementar (A1)	Utilizador elementar (A1)

Formação

	Grau	Classificação
2003/03/21 Concluído	Agregação (Título de Agregado) Universidade do Algarve, Portugal "n/a" (TESE/DISSERTAÇÃO)	By unanimity
1987 Concluído	Bioquímica (Doutoramento) Universidade de Lisboa Faculdade de Ciências, Portugal	Com distinção
1985/06 Concluído	Doctorat (Doctorat) Especialização em Outra:Bioquímica Université Pierre et Marie Curie Ecole Doctorale Physiologie Physiopathologie, França "Activite Biologique de la Vitamine D3 Sulfoconjugee" (TESE/DISSERTAÇÃO)	Tres Honorable / with honors

Percurso profissional

Docência no Ensino Superior

	Categoria Profissional Instituição de acolhimento	Empregador
2006/04/01 - Atual	Professor Catedrático (Docente Universitário)	Universidade do Algarve, Portugal

2013 - 2019	Professor Catedrático (Docente Universitário)	Universidade do Algarve, Portugal

2013 - 2019	Professor Catedrático (Docente Universitário)	Universidade do Algarve, Portugal

1998/11/01 - 2006/03/31	Professor Associado (Docente Universitário)	Universidade do Algarve, Portugal

1992/11/01 - 1998/10/31	Professor Auxiliar (Docente Universitário)	Universidade do Algarve, Portugal

Cargos e Funções

	Categoria Profissional Instituição de acolhimento	Empregador
2018/12/19 - Atual	Secretária do Conselho Geral da AD-ABC	AD-ABC / ASSOCIAÇÃO PARA O DESENVOLVIMENTO DO CENTRO ACADÉMICO DE INVESTIGAÇÃO E FORMAÇÃO BIOMÉDICA DO ALGARVE, Portugal
	Faculdade de Medicina e Ciências Biomédicas, Universidade do Algarve, Portugal
2016/04/08 - Atual	membro	ABC / Algarve Biomedical Center, Portugal
	Universidade do Algarve, Portugal
2006/09/01 - Atual	Director, Licenciatura(Bachelor), Biomedical Sciences	Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal

2020/01/23 - 2024/01/31	Presidente	Sociedade Portuguesa de Genética, Portugal
	Sociedade Portuguesa de Genética, Portugal
2021/10/01 - 2023/09/30	Presidente do Conselho Científico	Faculdade de Medicina e Ciências Biomédicas, Universidade do Algarve, Portugal
	Faculdade de Medicina e Ciências Biomédicas, Universidade do Algarve, Portugal
2018/03/05 - 2023/03/31	Presidente da Assembleia Geral do CCMAR	Universidade do Algarve, Portugal
	Centro de Ciências do Mar, Portugal
2019/10/01 - 2021/09/30	Presidente do Conselho Científico	Universidade do Algarve, Portugal
	Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal
2018/10/01 - 2020/09/30	Presidente do Conselho Pedagógico	Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal

2018 - 2019	Conselho científico/técnico-científico ou orgão correspondente	Universidade do Algarve, Portugal

2018 - 2019	Conselho pedagógico	Universidade do Algarve, Portugal

2018 - 2019	Conselho científico/técnico-científico ou orgão correspondente	Universidade do Algarve, Portugal

2018 - 2019	Conselho pedagógico	Universidade do Algarve, Portugal

2016 - 2018	Coordenação ou direção de centro de investigação, departamento ou equivalente	Universidade do Algarve, Portugal

2016 - 2018	Coordenação ou direção de centro de investigação, departamento ou equivalente	Universidade do Algarve, Portugal

2013 - 2016	Conselho científico/técnico-científico ou orgão correspondente	Universidade do Algarve, Portugal

2013 - 2016	Conselho pedagógico	Universidade do Algarve, Portugal

2013 - 2016	Conselho científico/técnico-científico ou orgão correspondente	Universidade do Algarve, Portugal

2013 - 2016	Conselho pedagógico	Universidade do Algarve, Portugal

2012/11/01 - 2015/08/31	Presidente	Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal

2013 - 2015	Conselho de gestão ou orgão correspondente	Universidade do Algarve, Portugal

2013 - 2015	Coordenação ou direção de centro de investigação, departamento ou equivalente	Universidade do Algarve, Portugal

2013 - 2015	Diretor ou presidente da unidade orgânica	Universidade do Algarve, Portugal

2013 - 2015	Conselho de gestão ou orgão correspondente	Universidade do Algarve, Portugal

2013 - 2015	Coordenação ou direção de centro de investigação, departamento ou equivalente	Universidade do Algarve, Portugal

2013 - 2015	Diretor ou presidente da unidade orgânica	Universidade do Algarve, Portugal

2008/10/01 - 2012/11/01	Member of the Directive board- Dept Biomed and Medicine	Universidade do Algarve, Portugal

2005/01/01 - 2008/12/31	Presidente	Sociedade Portuguesa de Bioquimica, Portugal

2000/01/01 - 2000/04/30	Visiting Research Scientist at UCaliforniaSan Duego, division of Biology at the time	University of California San Diego Department of Chemistry and Biochemistry, Estados Unidos

1991/08/01 - 1992/10/31	Assistant Researcher Biologist at UCSan Diego, Dept Biology at the time	University of California San Diego Department of Chemistry and Biochemistry, Estados Unidos

1988/02/01 - 1991/07/31	Post doctotal fellowship from UCalifornia San Diego, dept of Biology (at the time)	University of California San Diego Department of Chemistry and Biochemistry, Estados Unidos

1986/01/01 - 1988/01/31	Post doctotal fellowship from UCalifornia Riverside, dept Biochemistry at the time	University of California Riverside Division of Biomedical Sciences, Estados Unidos

1985/07/01 - 1985/12/31	researcher	Assistance Publique - Hôpitaux de Paris, França

1978/01/01 - 1985/06/30	Técnica de laboratório	Association de Rheumatologie, França

Outros

	Categoria Profissional Instituição de acolhimento	Empregador
2010/06/01 - Atual	Member of the direction	Sociedade Portuguesa de Genética, Portugal

2009/09/01 - Atual	Director of the PhD Program in Biomedical Sciences	Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal

2008/01/01 - Atual	membro	European Society for Calcified Tissues, Bélgica
	Universidade do Algarve - Campus de Gambelas, Portugal
2005/01/01 - Atual	Founding Member	Centro de Ciências do Mar, Portugal
	Universidade do Algarve, Portugal
1994/01/01 - Atual	Founder and head of research group	Centro de Ciências do Mar, Portugal
	Universidade do Algarve - Campus de Gambelas, Portugal
1993/01/01 - Atual	membro	Sociedade Portuguesa de Bioquimica, Portugal
	Universidade do Algarve - Campus de Gambelas, Portugal
2015/10/01 - 2018/12/31	Chair /LS9 Panel–Starting Grants	European Research Council, Bélgica

2011/01/01 - 2018/12/31	Evaluator, ERC LS9 panel, Starting and Consolidator grant proposals	European Research Council, Bélgica

2009/01/01 - 2010/12/31	President of the General Assembly	Sociedade Portuguesa de Bioquimica, Portugal

Projetos

Bolsa

	Designação	Financiadores
2019 - 2024/06	European transdisciplinary networking platform for marine biotechnology COST ACTION CA 18238 Portuguese representative and member of Management Committee National Institute of Biology, Slovenia, Eslovénia	European Cooperation in Science and Technology (COST) Em curso
2020/04/01 - 2024/03/31	Understanding the pathophysiology of Keutel Syndrome: A path towards cure PhysPath-KS (EJPRD2019-0004-290 Investigador responsável Centro de Ciências do Mar, Portugal Faculdade de Medicina e Ciências Biomédicas, Universidade do Algarve, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2021/01/01 - 2023/06/30	MarEmPó POCI-01-0247-FEDER-047200 Investigador Universidade do Algarve - Campus de Gambelas, Portugal	COMPETE2020, CRESC Algarve 2020, PT2020 e FEDER Concluído
2018/11/01 - 2022/04/30	KCITAR ALGARVE ALG-08-5864-FSE-000004 K.CITAR/10IS00018 Investigador Universidade do Algarve - Campus de Gambelas, Portugal	Programa Operacional Regional do Algarve através do Fundo Social Europeu Concluído
2019/02/01 - 2021/12/31	Zebrafish as model to analyse CDKL5 function MDBR-19-104-CDKL5 Investigador responsável Centro de Ciências do Mar, Portugal Faculdade de Medicina e Ciências Biomédicas, Universidade do Algarve, Portugal	Orphan Disease center, University of Pennsylvania Medical Center Concluído
2018/01/01 - 2021/07/31	Novos compostos marinhos como fonte nutricional para uma melhoria de Qualidade e Bem estar de peixes em aquacultura. 16-02-01-FMP-0057 /OSTEOMAR Investigador responsável Universidade do Algarve - Campus de Gambelas, Portugal	uropean Maritime and Fisheries Fund (EMFF/FEAMP), Operational Programme MAR2020 Concluído
2018/01/01 - 2021/07/31	BLUE biotechnology as a road for innovation on human health aiming smart growth in Atlantic Area. APA/151/2016 /BLUE HUMAN Investigador responsável Universidade do Algarve - Campus de Gambelas, Portugal	European Regional Development Fund (ERDF/FEDER) through the Transnational Cooperation Programme Atlantic Area (Porto) Concluído
2017/04/01 - 2021/06/30	RED transfronteriza para el desarrollo de productos innovadores con microALGAs 055 ALGARED + 5E Investigador Universidade do Algarve, Portugal	European Regional Development Fund (ERDF/FEDER) Cooperation Programme INTERREG V-A Spain-Portugal (POCTEP) Concluído
2017/04/01 - 2021/06/30	Desenvolvimento e implementação de alimentos suplementados em macroalgas ricas em vitamina K no cultivo do Linguado 16-02-01-FMP-0058 / ALGASOLE Investigador Universidade do Algarve - Campus de Gambelas, Portugal	European Maritime and Fisheries Fund (EMFF/FEAMP), Operational Programme MAR2020 Concluído
2016/04/01 - 2019/03/31	Desenvolvimento de uma prémistura de micronutrientes para optimizar as dietas para larvas de peixes marinhos. POCI-01-0247-FEDER-017925 Investigador Universidade do Algarve, Portugal	Programa Operacional CRESC Algarve 2020. Concluído
2014/11/01 - 2015/12/31	Estudo piloto para melhoramento do status nutricional em vitamina K: optimização da reprodução e demonstração da melhoria na qualidade larvar de linguado 31-03-05-FEP-0073/ KLING Investigador Programa Operacional Pesca 2007-2013 (PROMAR), Portugal	Programa Operacional Pesca 2007-2013 (PROMAR) Concluído
2012 - 2015	iONE-FP7 project Implantable Organic Nano-Electronics FP7/FP7-NMP-2011-SMALL-5 Investigador Universidade do Algarve, Portugal	European Science Foundation Concluído
2012 - 2015	Desenvolvimento de rações optimizados para desenvolvimennto e crescimento do peixe zebra, um modelo com aplicações biomédicas ALG-01-0102-FEDER-23000 /zebrafeeds Investigador Universidade do Algarve, Portugal	ADI/FEDER Concluído
2011/06/01 - 2014/05/31	Intelligent Cell Surfaces (ICS) EuroBioSAS/0001/2010 Investigador Universidade do Algarve, Portugal	European Science Foundation Concluído
2012 - 2014	Development of innovating biomedical products from marine resources valorisation. 2011-1/164/MARMED Investigador Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal	European Regional Development Fund (ERDF/FEDER) through the Transnational Cooperation Programme Atlantic Area Concluído
2010 - 2013	Effects of dietary vitamin K supplementation on growth and skeletal development of teleost fish PTDC/MAR/105152/2008 Investigador Centro de Ciências do Mar, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2009 - 2013	Development and characterization of zebrafish stem cells: implications for transgenesis PTDC/MAR/105313/2008 Investigador Centro de Ciências do Mar, Portugal	Fundação para a Ciência e a Tecnologia Concluído

Projeto

	Designação	Financiadores
2022/10 - 2026/09	INTEC-International Network on Ectopic Calcifications XXX Member of International network Universiteit Gent, Bélgica National Institute of Biology, Slovenia, Eslovénia	Universiteit Gent European Cooperation in Science and Technology (COST) Em curso
2021/01/01 - 2025/12/31	Centre for Marine and Environmental Research LA/P/0101/2020 10.54499/LA/P/0101/2020 Centro de Ciências do Mar, Portugal Universidade do Porto Faculdade de Desporto, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2023/03/10 - 2024/09/09	ZF screen_Screening for molecules capable of rescuing CDKL5 deficiency phenotypes using Zebrafish models 2022.06526.PTDC 10.54499/2022.06526.PTDC Investigador responsável Centro de Ciências do Mar, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2020/03/01 - 2024/04/30	IDENTIFICATION OF NOVEL CDKL5 MOLECULAR TARGETS/PATHWAYS ASSOCIATED WITH SKELETAL DEFECTS PRESENT IN CDKL5 ASSOCIATED DISORDERS SFRH/BD/144230/2019 Orientador Faculdade de Medicina e Ciências Biomédicas, Universidade do Algarve, Portugal Centro de Ciências do Mar, Portugal	Fundação para a Ciência e a Tecnologia
2018/08/01 - 2024/01/31	Aquaculture meets Biomedicine: Innovation in skeletal health research /BIOMEDAQU GA 766347 -BIOMEDAQU Investigador responsável Faculdade de Medicina e Ciências Biomédicas, Universidade do Algarve, Portugal	Horizon 2020 Framework Programme EU Framework Programme for Research and Innovation Marie Sklodowska-Curie Actions Concluído
2020/01/01 - 2023/01/31	ZEBRABLOOM_Desenvolvimento de produtos comerciais formulados com microalgas para o enriquecimento de presas vivas de peixe-zebra ALG-01-0247-FEDER-039896 Investigador Universidade do Algarve, Portugal	COMPETE2020, CRESC Algarve 2020, PT2020 e FEDER Concluído
2018/08/01 - 2023/01/31	Biomedaqu / Aquaculture meets Biomedicine: Innovation in skeletal health research H2020-MSCA-ITN-2017 Investigador responsável Universidade do Algarve, Portugal Faculdade de Medicina e Ciências Biomédicas, Universidade do Algarve, Portugal	European Commission Marie Sklodowska-Curie Actions Concluído
2019/01/01 - 2019/12/31	Centre of Marine Sciences UID/Multi/04326/2019 Centro de Ciências do Mar, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2012/01/01 - 2015/07/31	DEEPBONE - Bone biology of deep-sea teleost fish PTDC/MAR/119656/2010 Investigador Centro de Ciências do Mar, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2010/01/01 - 2013/07/31	Studies for the establishement of GRP as a biomarker for vascular calcification PTDC/SAU-ESA/101186/2008 Investigador Centro de Ciências do Mar, Portugal Hospital de Faro, Portugal University of Minnesota Twin Cities Department of Medicine, Estados Unidos Instituto de Biotecnologia e Bioengenharia, Portugal Universidade do Algarve, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2011/01/01 - 2012/12/31	Strategic Project - LA 15 - 2011-2012 PEst-C/MAR/LA0015/2011 Centro de Investigação Marinha e Ambiental, Portugal Universidade do Porto Faculdade de Desporto, Portugal Centro de Ciências do Mar, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2008/08/01 - 2011/12/31	Dietary fatty acids as modulators of bone metabolism in gilthead sea bream (Sparus aurata) - FATTYBONE PTDC/MAR/70855/2006 Investigador Centro de Ciências do Mar, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2007/08/01 - 2010/07/31	Characterization of isoprenoids biosynthesis and determination of potential therapeutic targets PTDC/CVT/72083/2006 Investigador responsável Centro de Ciências do Mar, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2006/01/01 - 2008/12/31	Effects of xenobiotics in skeleton development and fin regeneration in fish POCI/MAR/60883/2004 Investigador Centro de Ciências do Mar, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2005/06/01 - 2008/06/30	Spatial-temporal pattern of expression and regulation of Matrix Gla Protein (MGP) during early development in X. laevis POCI/BIA-BCM/58677/2004 Investigador Centro de Ciências do Mar, Portugal Universidade do Algarve, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2005/06/01 - 2008/05/31	Characterisation of the folate and purine metabolism in the protozoan parasite Perkinsus atlanticus: identification of genes involved in these pathways and potential therapeuthic targets POCI/CVT/57982/2004 Investigador responsável Centro de Ciências do Mar, Portugal	Fundação para a Ciência e a Tecnologia Concluído

Outro

	Designação	Financiadores
2009 - 2024	Lab-it_Laboratório Itinerante de Biologia Molecular xxx Investigador responsável Ciência Viva, Portugal	Ciência Viva Não financiado
2016/09/01 - 2019/12/31	Insights into Matrix Gla protein (MGP) regulation in colorectal cancer MGP.SPG.Cancer Investigador responsável Centro de Ciências do Mar, Portugal	Portuguese Society of Gastroenterology Concluído
2013/10/01 - 2018/09/30	Clinical and molecular heterogeneity of Paget's disease of bone MOP 130457 Investigador Centro de Ciências do Mar, Portugal	Canadian Institutes of Health Research (CIHR) Operating grant program Concluído

Produções

Publicações

Artigo em conferência	Carletti, Alessio; Cardoso, Carlos; Juliao, Diana; Arteaga, Jorge; Sales, Sabrina; Gaudêncio, Maria; Ferreira, Inês; et al. "Biopotential of sea cucumbers (Echinodermata) and tunicates (Chordata) from the western coast of Portugal for the prevention and treatment of chronic illnesses". Trabalho apresentado em 1st International Electronic Conference on Nutrients - Nutritional and Microbiota Effects on Chronic Disease, Nothingham, 2020. Publicado • 10.3390/iecn2020-06994 Varela, Tatiana; Varela, Débora; Vitorino, Marta; Conceição, Natércia; Cancela, M. Leonor; Martins, Gil. "Zebrafish: an interesting model to study CDKL5 deficiency disorder". 2020. 10.1097/MD.0000000000019291 Saavedra, C.; Milan, M.; Cordero, D.; Leite, R.; Pena, J. B.; Delgado, M.; Liu, B.; et al. "Population genetics and transcriptomics of Manila Clam (Ruditapes philippinarum) and carpet-shell clam (R. decussatus): implications for aquaculture". 2017. Cancela, Leonor; Laizé, Vincent; Conceição, N.; Tiago, Daniel M.; Maia, A. T.; Bensimon-Brito, A.; Gavaia, Paulo J.. "Matrix Gla protein expression: a complex process involving the use of alternative promoters, multiple splicing events and microRNAs". Trabalho apresentado em FEBS International Workshop on New Developments in RNA Biology,, Tavira, 2012. Publicado Dias, J.; Colen, Rita; Rodrigues, V.; Aragão, C.; Engrola, S.; Viegas, Michel; Laizé, Vincent; Gavaia, Paulo J.; Cancela, Leonor. "Effect of variable levels of dietary cholesterol and plant sterols on the growth performance and bone metabolism in gilthead seabream (Sparus aurata) juveniles". Trabalho apresentado em XV International Symposium on Fish Nutrition and Feeding., Molde, 2012. Publicado Fernández, Ignacio; Cancela, Leonor; Gavaia, Paulo J.. "Temporal and spatial expression patterns of pregnane X receptor and vitamin K epoxide reductase genes, two core molecular players on fish vitamin K homeostasis and skeletal development.". Prague, 2012. Publicado Cardeira, J.; Mendes, A. C.; Pousão-Ferreira, P.; Cancela, Leonor; Gavaia, Paulo J.. "Development of chondroid tissues in lordotic-kyphotic Senegalese sole (Solea senegalensis)". Trabalho apresentado em Interdisciplinary Approaches in Fish Skeletal Biology, April 26-28, Tavira, Portugal., Tavira, 2011. Publicado Cardeira, J.; Nicolau, L.; Pousão-Ferreira, P.; Cancela, Leonor; Gavaia, Paulo J.. "Early skeletal development of meagre (Argyrosomus regius, Asso 1801)". 2010. Publicado Gavaia, Paulo J.; Richard, Nadège; Dâmaso, L.; Dinis, Maria Teresa; Pousão-Ferreira, P.; Engrola, S.; Conceição, L. E. C.; Cancela, Leonor. "Evaluation of the skeletal quality in Senegalese sole (Solea Senegalensis, Kaup) reared under intensive vs extensive conditions". 2010. Publicado Gavaia, Paulo J.; Richard, N.; Dâmaso, L.; Dinis, Maria Teresa; Pousão-Ferreira, P.; Engrola, S.; Conceição, L. E. C.; Cancela, Leonor. "Skeletal evaluation and technical improvements to decrease the incidence of skeletal deformities in Solea senegalensis, Kaup". 2009. Publicado Roberto, V.; Cavaco, S.; Simes, Dina; Gavaia, Paulo J.; Cancela, Leonor. "Mgp expression and accumulation in heart and kidney of turbot (Scophthalmus maximus)". 2009. Publicado Cardeira da Silva, J.; Dionísio, G.; Bensimon-Brito, A.; Cancela, Leonor; Gavaia, Paulo J.. "Skeletal development and performance of zebrafish Danio rerio (Hamilton, 1822) larvae and juvenile fish fed with different diets". 2009. Peres dos Santos, R.; Bensimon-Brito, A.; Gavaia, Paulo J.; Cancela, Leonor. "Warfarin effects in the skeletal development of zebrafish (Danio rerio)". 2009. Publicado Dionísio, G.; Brito, A. B.; Cancela, Leonor; Gavaia, Paulo J.. "Diets affect skeletal development in zebrafish (Danio rerio)". 2008. Cardeira da Silva, J.; Gavaia, Paulo J.; Brito, A. B.; Cancela, Leonor. "The use of enhanced green fluorescent protein to track matrix Gla protein expression during zebrafish (Danio rerio) development". 2008. Peres dos Santos, R.; Brito, A. B.; Cancela, Leonor; Gavaia, Paulo J.. "Developmental effects of warfin in the skeletogenesis of zebrafish (Danio rerio) larvae". 2008. Gavaia, Paulo J.; Cancela, Leonor. "Fish as a model organism to study skeletal development and associated pathologies". 2008. Brito, A. B.; Gavaia, Paulo J.; Cancela, Leonor. "Gene expression during regeneration of zebrafish (danio rerio) fins: relative expression levels of mineralization – related gla proteins". Trabalho apresentado em Meeting of European COST B23 Action "Oral Development and Regeneration”, Barcelona, 2007. Tiago, Daniel M.; Laizé, Vincent; Cancela, Leonor; Aureliano, M.. "Vanadate and bone metabolism: effect on proliferation and mineralization of fish bone-derived cells". 2007. Brito, A. B.; Cancela, Leonor; Gavaia, Paulo J.. "Expression of osteonectin correlates with levels of fin regeneration in zebrafish (Danio rerio". Trabalho apresentado em FEBS Journal, 2007. Publicado Pittman, K.; Rønnestad, I.; Gavaia, Paulo J.; Cancela, Leonor; Guerreiro, P. M.; Ribeiro, Laura; Aragão, C.; et al. "Fish Larval Research: a tool for sustainable food production and understanding environmental impacts on developing organisms". Trabalho apresentado em Aquaculture Europe, 2007. Publicado Brito, A. B.; Gavaia, Paulo J.; Cancela, Leonor. "Regeneration in Zebrafish (Danio rerio) fins: pattern of expression of mineralization related Gla proteins". Trabalho apresentado em XVth National Congress of Biochemistry Aveiro, 8-10 December 2006, Aveiro, 2006. Publicado Laizé, Vincent; Gavaia, Paulo J.; Viegas, C. S. B.; Cancela, Leonor. "Whole-genome sequence analysis: Evidences for new osteocalcin isoforms in fish and tetrapods". Trabalho apresentado em European Society for Evolutionary DEvelopmental Biology, Prague, 2006. Publicado Roberto, V.; Gavaia, Paulo J.; Cancela, Leonor. "Vertebral deformities and local accumulation of gla proteins in sparus aurata". Trabalho apresentado em Aquaculture Europe (AQUA2006), 9-13 May 2006, Florence, Italy, Florence, 2006. Publicado Mariani, Valentina; Viegas, C. A.; Gavaia, Paulo J.; Cancela, Leonor; Giuffra, Elisabetta. "Comparative analysis of gene expression profiles among distantly related fish species. Insight into skeletal and immunological systems". 2005. Cancela, Leonor; Laizé, Vincent; Simes, Dina; Gavaia, Paulo J.; Conceição, N.; Viegas, C. S. B.; Pombinho, A. R.; et al. "Proteínas gla do osso e cartilagem: importância dos anfíbios e peixes como modelos biológicos para elucidação da sua função e evolução - gla proteins in bone and cartilage: the importance of fish and amphibian models to understand their function and evolution". 2005. Gomes, H.L.; Leite, R.B.; Afonso, R.; Stallinga, P.; Cancela, M.L.; Gomes, Henrique L.; Leite, R. B.; Stallinga, Peter; Cancela, M. Leonor. "A microelectrode impedance method to measure interaction of cells". 2004. https://dx.doi.org/10.1109/ICSENS.2004.1426344 Viegas, C. S. B.; Gavaia, Paulo J.; Ortiz-Delgado, J. B.; Sarasquete, C.; Cancela, Leonor. "Gla proteins as markers for studies of skeletal development and malformations in new aquaculture fish species (Pagrus auriga, Diplodus sargo and Scophtalmus maximus)". 2004. Brito, A. B.; Rønnestad, I.; Gavaia, Paulo J.; Viegas, C. S. B.; Cancela, Leonor. "Expression of the oligopeptide transporter PepT1 (Solute carrier family 15, member 1), in fed and starved larval Zebra fish (Danio rerio)". 2004. Rønnestad, I.; Gavaia, Paulo J.; Viegas, C. S. B.; Cancela, Leonor. "Cloning and ontogenetic expression of the oligopeptide transporter PepT1 (Solute carrier family 15, member 1), in fed and starved larval Atlantic cod, Gadus morhua L". 2004. Domingues, S.; Gavaia, Paulo J.; Cancela, Leonor. "Effect of Citral in zebrafish bone structure and circulatory system during the first stages of development". 2004. Gavaia, Paulo J.; Simes, Dina; Ortiz-Delgado, J. B.; Sarasquete, C.; Cancela, Leonor. "Simultaneous detection of osteocalcin and matrix gla protein in developmental stages of zebra fish (Danio rerio)". 2003. http://dx.doi.org/10.1007/s00223-003-5002-5 Leite, Ricardo B.; Gavaia, Paulo J.; Cancela, Leonor. "Localization of sites of expression of the BAT-1 gene enconding a RNA Helicase". 2002. Pinto, J. P.; Gavaia, Paulo J.; Simes, Dina; Kelsh, R. N.; Cancela, Leonor. "Localization of osteocalcin (BGP) during fish (Sparus aurata) development by in situ hybridization and immunohistochemistry: comparison between gene expression/protein distribution and skeletal mineralization". 2001. Gavaia, Paulo J.; Dinis, Maria Teresa; Cancela, Leonor. "Skeletal development as an assessment criteria for larval Solea senegalensis (Kaup) quality". Trabalho apresentado em AQUA 2000 - Responsible Aquaculture in the New Millennium, Nice, 2000. Publicado Gavaia, Paulo J.; Dinis, Maria Teresa; Cancela, Leonor. "Detection of skeletal abnormalities in hatchery reared Solea senegalensis (Kaup, 1858) by a whole mount double staining technique". Trabalho apresentado em IV Iberian Congress on Biotechnology, I Ibero-American Meeting on Biotechnology- Biotec’98., Guimarães, 1998. Publicado Gavaia, Paulo J.; Faustino, M.; Cancela, Leonor. "Identification of bone gla protein during early development of Solea Senegalensis". Trabalho apresentado em X Congresso Nacional de Bioquímica., Braga, 1996. Publicado
Artigo em revista	Carletti, Alessio; Gavaia, Paulo Jorge; Cancela, Maria Leonor; Laizé, Vincent. "Metabolic bone disorders and the promise of marine osteoactive compounds". Cellular and Molecular Life Sciences 81 1 (2024): http://dx.doi.org/10.1007/s00018-023-05033-x. 10.1007/s00018-023-05033-x Carletti, Alessio; Rosa, Joana T.; Pes, Katia; Borges, Inês; Santos, Tamára; Barreira, Luísa; Varela, João; et al. "The osteogenic and mineralogenic potential of the microalgae Skeletonema costatum and Tetraselmis striata CTP4 in fish models". Cellular and Molecular Life Sciences 80 10 (2023): http://dx.doi.org/10.1007/s00018-023-04953-y. Acesso aberto • Publicado • 10.1007/s00018-023-04953-y Adrião, Andreia; Mariano, Sara; Mariano, José; Gavaia, Paulo J.; Cancela, M. Leonor; Vitorino, Marta; Conceição, Natércia. "mef2ca and mef2cb Double Mutant Zebrafish Show Altered Craniofacial Phenotype and Motor Behaviour". Biomolecules 13 5 (2023): 805. http://dx.doi.org/10.3390/biom13050805. Publicado • 10.3390/biom13050805 Saavedra, Carlos; Milan, Massimo; Leite, Ricardo B.; Cordero, David; Patarnello, Tomaso; Cancela, M. Leonor; Bargelloni, Luca. "Transcriptional Profiling of Populations in the Clam Ruditapes decussatus Suggests Genetically Determined Differentiation in Gene Expression along Parallel Temperature Gradients and between Races of the Atlantic Ocean and West Mediterranean Sea". Fishes 8 4 (2023): 203. http://dx.doi.org/10.3390/fishes8040203. Acesso aberto • Publicado • 10.3390/fishes8040203 Santos, João M. A.; Laizé, Vincent; Gavaia, Paulo J.; Conceição, Natércia; Cancela, M. Leonor. "Zebrafish Models to Study Ectopic Calcification and Calcium-Associated Pathologies". International Journal of Molecular Sciences 24 4 (2023): 3366. http://dx.doi.org/10.3390/ijms24043366. Acesso aberto • Publicado • 10.3390/ijms24043366 Varela, Débora; Varela, Tatiana; Conceição, Natércia; Cancela, M. Leonor. "Regulation of human ZNF687, a gene associated with Paget's disease of bone". The International Journal of Biochemistry & Cell Biology 154 (2023): 106332. http://dx.doi.org/10.1016/j.biocel.2022.106332. 10.1016/j.biocel.2022.106332 Poudel, Sunil; Martins, Gil; Cancela, M. Leonor; Gavaia, Paulo J.. "Resveratrol-Mediated Reversal of Doxorubicin-Induced Osteoclast Differentiation". International Journal of Molecular Sciences 23 23 (2022): 15160. http://dx.doi.org/10.3390/ijms232315160. Publicado • 10.3390/ijms232315160 Cardeira-da-Silva, João; Bensimon-Brito, Anabela; Tarasco, Marco; Brandão, Ana S.; Rosa, Joana T.; Borbinha, Jorge; Almeida, Paulo J.; et al. "Fin ray branching is defined by TRAP+ osteolytic tubules in zebrafish". Proceedings of the National Academy of Sciences 119 48 (2022): http://dx.doi.org/10.1073/pnas.2209231119. Acesso aberto • Publicado • 10.1073/pnas.2209231119 Sunil Poudel; Gil Martins; M. Leonor Cancela; Paulo J. Gavaia. "Regular Supplementation with Antioxidants Rescues Doxorubicin-Induced Bone Deformities and Mineralization Delay in Zebrafish". Nutrients (2022): https://doi.org/10.3390/nu14234959. 10.3390/nu14234959 Silva, Iris A.L.; Varela, Débora; Cancela, M. Leonor; Conceição, Natércia. "Zebrafish optineurin: genomic organization and transcription regulation". Genome 65 10 (2022): 513-523. http://dx.doi.org/10.1139/gen-2022-0019. Acesso aberto • 10.1139/gen-2022-0019 Tarasco, Marco; Gavaia, Paulo J.; Bensimon-Brito, Anabela; Cordelières, Fabrice P.; Santos, Tamára; Martins, Gil; de Castro, Daniela T.; et al. "Effects of pristine or contaminated polyethylene microplastics on zebrafish development". Chemosphere 303 (2022): 135198. http://dx.doi.org/10.1016/j.chemosphere.2022.135198. Publicado • 10.1016/j.chemosphere.2022.135198 Joana T. Rosa; Marco Tarasco; Paulo J. Gavaia; M. Leonor Cancela; Vincent Laizé. "Screening of Mineralogenic and Osteogenic Compounds in Zebrafish—Tools to Improve Assay Throughput and Data Accuracy". Pharmaceuticals (2022): https://doi.org/10.3390/ph15080983. 10.3390/ph15080983 Márcio Simão; Natércia Conceição; Susana Imaginário; João Amaro; Maria Leonor Cancela. "Lab-It Is Taking Molecular Genetics to School". BioChem (2022): https://doi.org/10.3390/biochem2020011. 10.3390/biochem2020011 Varela, Tatiana; Varela, Débora; Martins, Gil; Conceição, Natércia; Cancela, M. Leonor. "Cdkl5 mutant zebrafish shows skeletal and neuronal alterations mimicking human CDKL5 deficiency disorder". Scientific Reports 12 1 (2022): http://dx.doi.org/10.1038/s41598-022-13364-1. Acesso aberto • Publicado • 10.1038/s41598-022-13364-1 Carletti, Alessio; Cardoso, Carlos; Lobo-Arteaga, Jorge; Sales, Sabrina; Juliao, Diana; Ferreira, Inês; Chainho, Paula; et al. "Antioxidant and Anti-inflammatory Extracts From Sea Cucumbers and Tunicates Induce a Pro-osteogenic Effect in Zebrafish Larvae". Frontiers in Nutrition 9 (2022): 888360. http://dx.doi.org/10.3389/fnut.2022.888360. Acesso aberto • Publicado • 10.3389/fnut.2022.888360 Adrião, Andreia; Santana, Isabel; Ribeiro, Carolina; Cancela, M. Leonor; Conceição, Natércia; Grazina, Manuela. "Identification of a novel mutation in MEF2C gene in an atypical patient with frontotemporal lobar degeneration". Neurological Sciences 43 1 (2022): 319-326. http://dx.doi.org/10.1007/s10072-021-05269-0. Acesso aberto • Publicado • 10.1007/s10072-021-05269-0 Poudel, Sunil; Izquierdo M; Leonor Cancela; Gavaia, P; Sunil Poudel; Marisol Izquierdo; Maria Leonor Cancela; Paulo J. Gavaia. "Reversal of Doxorubicin-induced bone loss and mineralization by supplementation of Resveratrol and MitoTEMPO in the early development of Sparus aurata.". Nutrients 14 6 (2022): 1154-1154. https://doi.org/10.3390/nu14061154. Acesso aberto • Publicado • 10.3390/nu14061154 Tarasco, Marco; Gavaia, Paulo J.; Bensimon-Brito, Anabela; Cardeira-da-Silva, João; Ramkumar, Srinath; Cordelières, Fabrice P.; Günther, Stefan; et al. "New insights into benzo[¿]pyrene osteotoxicity in zebrafish". Ecotoxicology and Environmental Safety 226 (2021): 112838. http://dx.doi.org/10.1016/j.ecoenv.2021.112838. Publicado • 10.1016/j.ecoenv.2021.112838 Roberto, Vânia P.; Surget, Gwladys; Le Lann, Klervi; Mira, Sara; Tarasco, Marco; Guérard, Fabienne; Poupart, Nathalie; et al. Autor correspondente: Cancela, M. Leonor. "Antioxidant, Mineralogenic and Osteogenic Activities of Spartina alterniflora and Salicornia fragilis Extracts Rich in Polyphenols". Frontiers in Nutrition 8 (2021): 719438.. http://dx.doi.org/10.3389/fnut.2021.719438. Acesso aberto • Publicado • 10.3389/fnut.2021.719438 Varela, Tatiana; Conceição, Natércia; Laizé, Vincent; Cancela, M. Leonor. Autor correspondente: Cancela, M. Leonor. "Transcriptional regulation of human DUSP4 gene by cancer-related transcription factors". Journal of Cellular Biochemistry 122 10 (2021): 1556-1566. http://dx.doi.org/10.1002/jcb.30078. Acesso aberto • Publicado • 10.1002/jcb.30078 Rosa, Joana T.; Laizé, Vincent; Gavaia, Paulo J.; Cancela, M. Leonor. "Fish Models of Induced Osteoporosis". Frontiers in Cell and Developmental Biology 9 (2021): http://dx.doi.org/10.3389/fcell.2021.672424. Publicado • 10.3389/fcell.2021.672424 Simão, Márcio; Cancela, M. Leonor. "Musculoskeletal complications associated with pathological iron toxicity and its molecular mechanisms". Biochemical Society Transactions 49 2 (2021): 747-759. http://dx.doi.org/10.1042/bst20200672. Acesso aberto • Publicado • 10.1042/bst20200672 Kempf, Hervé; Murshed, Monzur; ML Cancela; Laizé, V; Conceiçao, Natercia. "Keutel Syndrome, a Review of 50 Years of Literature". Frontiers in Cell and Developmental Biology 9 642136 (2021): 275-283. http://dx.doi.org/10.3389/fcell.2021.642136. Acesso aberto • Publicado • 10.3389/fcell.2021.642136 Varela, Débora; Varela, Tatiana; Conceição, Natércia; Ferreira, Ângela; Marques, Nuno; Silva, Ana Paula; Azevedo, Pedro; et al. Autor correspondente: Cancela, M. Leonor. "Functional analysis of two novel TBX5 variants present in individuals with Holt Oram syndrome with different clinical manifestations". Molecular Genetics and Genomics 296 4 (2021): 809-821. http://dx.doi.org/10.1007/s00438-021-01781-2. Acesso aberto • Publicado • 10.1007/s00438-021-01781-2 Rosa, Joana; Carletti, Alessio; Varela, Tatiana; Gavaia, Paulo J.; Cancela, M. Leonor; Laizé, Vincent. "Identification of bone anabolic compounds of marine origin using a zebrafish pipeline". Bone Reports 14 (2021): 100985. http://dx.doi.org/10.1016/j.bonr.2021.100985. Acesso aberto • Publicado • 10.1016/j.bonr.2021.100985 Poudel, Sunil; Izquierdo, Marisol; Cancela, M. Leonor; Gavaia, Paulo J.. "Reversal of Doxorubicin-induced bone loss by antioxidant supplement". Bone Reports 14 (2021): 100984. http://dx.doi.org/10.1016/j.bonr.2021.100984. Acesso aberto • Publicado • 10.1016/j.bonr.2021.100984 Rotter, Ana; Barbier, Michéle; Bertoni, Francesco; Bones, Atle M.; Cancela, M. Leonor; Carlsson, Jens; Carvalho, Maria F.; et al. "The Essentials of Marine Biotechnology". Frontiers in Marine Science 8 (2021): http://dx.doi.org/10.3389/fmars.2021.629629. Acesso aberto • Publicado • 10.3389/fmars.2021.629629 Varela, Débora; Conceição, Natércia; Cancela, M. Leonor. Autor correspondente: Cancela, M. Leonor. "Transcriptional regulation of human T-box 5 gene (TBX5) by bone- and cardiac-related transcription factors". Gene 768 (2021): 145322. http://dx.doi.org/10.1016/j.gene.2020.145322. Acesso aberto • Publicado • 10.1016/j.gene.2020.145322 Cancela, M Leonor; Conceiçao, Natercia; Varela, Tatiana; Laizé, V. "A expressão dos transcritos do gene DUSP4 como potencial biomarcador no cancro colorretal.". UALGORITMO 3 (2021): 25-28. Publicado Simão, Márcio; Leite, Ricardo B.; Cancela, M. Leonor. "Expression of four new ferritins from grooved carpet shell clam Ruditapes decussatus challenged with Perkinsus olseni and metals (Cd, Cu and Zn)". Aquatic Toxicology 229 (2020): 105675. http://dx.doi.org/10.1016/j.aquatox.2020.105675. Publicado • 10.1016/j.aquatox.2020.105675 Shea, M. Kyla; Booth, Sarah L.; Harshman, Stephanie G.; Smith, Donald; Carlson, Cathy S.; Harper, Lindsey; Armstrong, Alexandra R.; et al. "The effect of vitamin K insufficiency on histological and structural properties of knee joints in aging mice". Osteoarthritis and Cartilage Open 2 3 (2020): 100078. http://dx.doi.org/10.1016/j.ocarto.2020.100078. Publicado • 10.1016/j.ocarto.2020.100078 Tarasco, Marco; Cordelières, Fabrice P.; Cancela, M. Leonor; Laizé, Vincent. "ZFBONE: An ImageJ toolset for semi-automatic analysis of zebrafish bone structures". Bone 138 (2020): 115480. http://dx.doi.org/10.1016/j.bone.2020.115480. Publicado • 10.1016/j.bone.2020.115480 Caiado, Helena; Conceição, Natércia; Tiago, Daniel; Marreiros, Ana; Vicente, Susana; Enriquez, Jose Luis; Vaz, Ana Margarida; et al. "Data on the evaluation of FGF2 gene expression in Colorectal Cancer". Data in Brief 31 (2020): 105765. http://dx.doi.org/10.1016/j.dib.2020.105765. Publicado • 10.1016/j.dib.2020.105765 Varela, Tatiana; Laizé, Vincent; Conceição, Natércia; Caldeira, Paulo; Marreiros, Ana; Guerreiro, Horácio; Cancela, M Leonor. "Expression of DUSP4 transcript variants as a potential biomarker for colorectal cancer". Biomarkers in Medicine 14 8 (2020): 639-650. http://dx.doi.org/10.2217/bmm-2019-0369. Publicado • 10.2217/bmm-2019-0369 Rotter, Ana; Bacu, Ariola; Barbier, Michèle; Bertoni, Francesco; Bones, Atle M.; Cancela, M. Leonor; Carlsson, Jens; et al. "A New Network for the Advancement of Marine Biotechnology in Europe and Beyond". Frontiers in Marine Science 7 278 (2020): http://dx.doi.org/10.3389/fmars.2020.00278. Acesso aberto • Publicado • 10.3389/fmars.2020.00278 Vijayakumar, Parameswaran; Cardeira, João; Laizé, Vincent; Gavaia, Paulo J.; Cancela, M. Leonor. "Cells Isolated from Regenerating Caudal Fin of Sparus aurata Can Differentiate into Distinct Bone Cell Lineages". Marine Biotechnology 22 3 (2020): 333-347. http://dx.doi.org/10.1007/s10126-019-09937-3. Publicado • 10.1007/s10126-019-09937-3 Tarasco, Marco; Martins, Gil; Gavaia, Paulo J.; Bebianno, Maria J.; Cancela, M. Leonor; Laizé, Vincent. "ZEB316: A Small Stand-Alone Housing System to Study Microplastics in Small Teleosts". Zebrafish 17 1 (2020): 18-26. http://dx.doi.org/10.1089/zeb.2019.1801. 10.1089/zeb.2019.1801 ML Cancela. "Isolation, Culture, and Differentiation of Blastema Cells from the Regenerating Caudal Fin of Zebrafish". Fishes (2020): http://dx.doi.org/10.3390/fishes5010006. 10.3390/fishes5010006 ML Cancela. "Evaluation of MGP gene expression in colorectal cancer". Gene (2020): http://dx.doi.org/10.1016/j.gene.2019.144120. 10.1016/j.gene.2019.144120 Gil Martins; Laura Ribeiro; Ana Candeias-Mendes; Patrícia Diogo; Margarida Gamboa; Marisa Barata; Maria Leonor Cancela; Pedro Pousão-Ferreira; Paulo Jorge Gavaia. "Reduction of skeletal anomalies in meagre ( Argyrosomus regius , Asso, 1801) through early introduction of inert diet". Aquaculture Research 50 10 (2019): 2782-2792. https://doi.org/10.1111/are.14230. Publicado • 10.1111/are.14230 Granadeiro, Luis; Dirks, Ron P.; Ortiz-Delgado, Juan B.; Gavaia, Paulo J.; Sarasquete, Carmen; Laizé, Vincent; Cancela, M. Leonor; Fernández, Ignacio. "Warfarin-exposed zebrafish embryos resembles human warfarin embryopathy in a dose and developmental-time dependent manner – From molecular mechanisms to environmental concerns". Ecotoxicology and Environmental Safety 181 (2019): 559-571. http://dx.doi.org/10.1016/j.ecoenv.2019.06.042. Publicado • 10.1016/j.ecoenv.2019.06.042 Santos, João; Mendes-Silva, Leonardo; Afonso, Vanessa; Martins, Gil; Machado, Rui; Lopes, Joao; Cancela, M. Leonor; et al. "Exogenous WNT5A and WNT11 proteins rescue CITED2 dysfunction in mouse embryonic stem cells and zebrafish morphants". Cell Death & Disease 10 8 (2019): 582. http://hdl.handle.net/10400.1/12749. Acesso aberto • Publicado • 10.1038/s41419-019-1816-6 ML Cancela. "Intracellular iron uptake is favored in Hfe -KO mouse primary chondrocytes mimicking an osteoarthritis-related phenotype". BioFactors (2019): http://dx.doi.org/10.1002/biof.1520. 10.1002/biof.1520 ML Cancela. "Anti-Osteogenic Activity of Cadmium in Zebrafish". Fishes (2019): http://dx.doi.org/10.3390/fishes4010011. 10.3390/fishes4010011 Bäck, Magnus; Aranyi, Tamas; Cancela, M. Leonor; Carracedo, Miguel; Conceição, Natércia; Leftheriotis, Georges; Macrae, Vicky; et al. "Endogenous Calcification Inhibitors in the Prevention of Vascular Calcification: A Consensus Statement From the COST Action EuroSoftCalcNet". Frontiers in Cardiovascular Medicine 5 (2019): 196. http://dx.doi.org/10.3389/fcvm.2018.00196. Acesso aberto • Publicado • 10.3389/fcvm.2018.00196 Fernandez, Ignacio; Fernandes, Jorge M. O.; Roberto, Vania P.; Kopp, Martina; Oliveira, Catarina; Riesco, Marta F.; Dias, Jorge; et al. "Circulating small non-coding RNAs provide new insights into vitamin K nutrition and reproductive physiology in teleost fish". Biochimica Et Biophysica Acta-General Subjects 1863 1 (2019): 39-51. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000452343100005&KeyUID=WOS:000452343100005. Acesso aberto • Publicado • 10.1016/j.bbagen.2018.09.017 Carvalho, Filipe R.; Calado, Sofia M.; Silva, Gabriela A.; Diogo, Gabriela S.; Moreira da Silva, Joana; Reis, Rui L.; Cancela, M. Leonor; Gavaia, Paulo J.. "Altered bone microarchitecture in a type 1 diabetes mouse model Ins2 Akita". Journal of Cellular Physiology 234 6 (2018): 9338-9350. http://dx.doi.org/10.1002/jcp.27617. Publicado • 10.1002/jcp.27617 Roberto, Vânia Palma; Gavaia, Paulo; Nunes, Maria João; Rodrigues, Elsa; Cancela, Maria Leonor; Tiago, Daniel Martins. "Evidences for a New Role of miR-214 in Chondrogenesis". Scientific Reports 8 1 (2018): http://dx.doi.org/10.1038/s41598-018-21735-w. Acesso aberto • Publicado • 10.1038/s41598-018-21735-w Fernández, I.; Gavaia, P.J.; Laizé, V.; Cancela, M.L.. "Fish as a model to assess chemical toxicity in bone". Aquatic Toxicology 194 (2018): 208-226. http://www.scopus.com/inward/record.url?eid=2-s2.0-85035770425&partnerID=MN8TOARS. Publicado • 10.1016/j.aquatox.2017.11.015 Vitorino, Marta; Cunha, Nidia; Conceicao, Natercia; Leonor Cancela, M.. "Expression pattern of cdkl5 during zebrafish early development: implications for use as model for atypical Rett syndrome". Molecular Biology Reports 45 4 (2018): 445-451. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000439948500006&KeyUID=WOS:000439948500006. Publicado • 10.1007/s11033-018-4180-1 Fazenda, C.; Martins, G.; Gavaia, P. J.; Cancela, M. L.; Conceicao, N.. "Generation of zebrafish Danio rerio (Hamilton, 1822) transgenic lines overexpressing a heat-shock mediated Gla-rich protein". Journal of Applied Ichthyology 34 2 (2018): 472-480. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000428797200026&KeyUID=WOS:000428797200026. Publicado • 10.1111/jai.13662 Cardeira, J.; Laize, V.; Martins, G.; Cancela, M. L.; Gavaia, P. J.. "An overview on the teleost bone mechanophysiology". Journal of Applied Ichthyology 34 2 (2018): 440-448. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000428797200022&KeyUID=WOS:000428797200022. Acesso aberto • Publicado • 10.1111/jai.13661 Carson, Matthew A.; Nelson, John; Cancela, M. Leonor; Laize, Vincent; Gavaia, Paulo J.; Rae, Margaret; Heesch, Svenja; et al. "Screening for osteogenic activity in extracts from Irish marine organisms: The potential of Ceramium pallidum". Plos One 13 11 (2018): http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000451755800060&KeyUID=WOS:000451755800060. Acesso aberto • Publicado • 10.1371/journal.pone.0207303 Eckhard Witten, P.; Leonor Cancela, M.. "What aquaculture does for taxonomy, evo-devo, palaeontology, biomechanics and biomedical research". Journal of Applied Ichthyology 34 2 (2018): 429-430. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000428797200020&KeyUID=WOS:000428797200020. Acesso aberto • Publicado • 10.1111/jai.13670 Vitorino, M.; Conceicao, N.; Cancela, M. L.; Conceição, N.. "Zebrafish (Danio rerio, Hamilton-Buchanan, 1822) as a model to study bone diseases associated with Rett syndrome". Journal of Applied Ichthyology 34 2 (2018): 489-500. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000428797200028&KeyUID=WOS:000428797200028. Publicado • 10.1111/jai.13667 Silva, Iris A. L.; Conceiceao, Natercia; Gagnon, Edith; Brown, Jacques P.; Cancela, M. Leonor; Michou, Laetitia. "Molecular effect of an OPTN common variant associated to Paget's disease of bone". Plos One 13 5 (2018): http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000432537100031&KeyUID=WOS:000432537100031. Acesso aberto • Publicado • 10.1371/journal.pone.0197543 Ferreira-Rodriguez, Noe; Fernandez, Ignacio; Leonor Cancela, M.; Pardo, Isabel. "Multibiomarker response shows how native and non-native freshwater bivalves differentially cope with heat-wave events". Aquatic Conservation-Marine and Freshwater Ecosystems 28 4 (2018): 934-943. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000442565600016&KeyUID=WOS:000442565600016. Publicado • 10.1002/aqc.2884 Laize, Vincent; Gavaia, Paulo J.; Tarasco, Marco; Viegas, Michael N.; Caria, Joana; Luis, Nuno; Leonor Cancela, M.. "Osteotoxicity of 3-methylcholanthrene in fish". Ecotoxicology and Environmental Safety 161 (2018): 721-728. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000439956700087&KeyUID=WOS:000439956700087. Acesso aberto • Publicado • 10.1016/j.ecoenv.2018.06.035 Carson, Matthew A.; Nelson, John; Cancela, M. Leonor; Laize, Vincent; Gavaia, Paulo J.; Rae, Margaret; Heesch, Svenja; et al. "Red algal extracts from Plocamium lyngbyanum and Ceramium secundatum stimulate osteogenic activities in vitro and bone growth in zebrafish larvae". Scientific Reports 8 (2018): http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000432275800024&KeyUID=WOS:000432275800024. Acesso aberto • Publicado • 10.1038/s41598-018-26024-0 Rosa, Joana; Cox, Cymon J.; Leonor Cancela, M.; Laize, Vincent. "Identification of a fish short-chain dehydrogenase/reductase associated with bone metabolism". Gene 645 (2018): 137-145. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000424182600019&KeyUID=WOS:000424182600019. Acesso aberto • Publicado • 10.1016/j.gene.2017.12.021 Roberto, V. P.; Martins, G.; Pereira, A.; Rodrigues, S.; Grenha, A.; Pinto, W.; Cancela, M. L.; Dias, J.; Gavaia, P. J.. "Insights from dietary supplementation with zinc and strontium on the skeleton of zebrafish, Danio rerio (Hamilton, 1822) larvae: From morphological analysis to osteogenic markers". Journal of Applied Ichthyology 34 2 (2018): 512-523. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000428797200030&KeyUID=WOS:000428797200030. Acesso aberto • Publicado • 10.1111/jai.13664 Simao, Marcio; Camacho, Antonio; Cohen-Solal, Martine; Jorge Pinto, I.; Porto, Graca; Korng, Ea Hang; Leonor Cancela, M.. "Iron enriched diet in association with Hfe loss of function promote iron toxicity mechanism and accelerate bone loss phenotype". Free Radical Biology and Medicine 120 (2018): S148-S148. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000432836500474&KeyUID=WOS:000432836500474. Acesso aberto • Publicado • 10.1016/j.freeradbiomed.2018.04.489 Simao, Marcio; Camacho, Antonio; Ostertag, Agnes; Cohen-Solal, Martine; Jorge Pinto, I.; Porto, Graca; Korng, Ea Hang; Leonor Cancela, M.. "Iron-enriched diet contributes to early onset of osteoporotic phenotype in a mouse model of hereditary hemochromatosis". Plos One 13 11 (2018): http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000450138500102&KeyUID=WOS:000450138500102. Acesso aberto • Publicado • 10.1371/journal.pone.0207441 Silva, Iris A. L.; Conceição, Natércia; Gagnon, Edith; Caiado, Helena; Brown, Jacques P.; Gianfrancesco, Fernando; Michou, Laëtitia; et al. "Effect of genetic variants of OPTN in the pathophysiology of Paget's disease of bone". Biochimica et Biophysica Acta - Molecular Basis of Disease 1864 1 (2018): 143-151. http://hdl.handle.net/10400.1/10678. Acesso aberto • Publicado • 10.1016/j.bbadis.2017.10.008 Saavedra, Carlos; Milan, Massimo; Leite, Ricardo B.; Cordero, David; Patarnello, Tomaso; Cancela, M. Leonor; Bargelloni, Luca. "A Microarray Study of Carpet-Shell Clam (Ruditapes decussatus) Shows Common and Organ-Specific Growth-Related Gene Expression Differences in Gills and Digestive Gland". Frontiers in Physiology 8 (2017): 943. http://dx.doi.org/10.3389/fphys.2017.00943. Acesso aberto • Publicado • 10.3389/fphys.2017.00943 Carvalho, Filipe R.; Fernandes, Ana R.; Cancela, M. Leonor; Gavaia, Paulo J.. "Improved regeneration and de novo bone formation in a diabetic zebrafish model treated with paricalcitol and cinacalcet". Wound Repair and Regeneration 25 3 (2017): 432-442. http://dx.doi.org/10.1111/wrr.12536. Acesso aberto • Publicado • 10.1111/wrr.12536 Marques, C.; Roberto, V.P.; Granadeiro, L.; Trindade, M.; Gavaia, P.J.; Laizé, V.; Cancela, M.L.; Fernández, I.. "The xenobiotic sensor PXR in a marine flatfish species (Solea senegalensis): Gene expression patterns and its regulation under different physiological conditions". Marine Environmental Research 130 (2017): 187-199. http://www.scopus.com/inward/record.url?eid=2-s2.0-85026404560&partnerID=MN8TOARS. Acesso aberto • Publicado • 10.1016/j.marenvres.2017.07.021 Surget, G.; Roberto, V.P.; Le Lann, K.; Mira, S.; Guérard, F.; Laizé, V.; Poupart, N.; Cancela, M.L.; Stiger-Pouvreau, V.. "Marine green macroalgae: a source of natural compounds with mineralogenic and antioxidant activities". Journal of Applied Phycology 29 1 (2017): 575-584. http://www.scopus.com/inward/record.url?eid=2-s2.0-84992135652&partnerID=MN8TOARS. Publicado • 10.1007/s10811-016-0968-3 Ferreira-Rodríguez, N.; Fernández, I.; Varandas, S.; Cortes, R.; Cancela, M.L.; Pardo, I.. "The role of calcium concentration in the invasive capacity of Corbicula fluminea in crystalline basins". Science of the Total Environment 580 (2017): 1363-1370. http://www.scopus.com/inward/record.url?eid=2-s2.0-85008415001&partnerID=MN8TOARS. Acesso aberto • Publicado • 10.1016/j.scitotenv.2016.12.100 Tarasco, M.; Laizé, V.; Cardeira, J.; Cancela, M.L.; Gavaia, P.J.. "The zebrafish operculum: A powerful system to assess osteogenic bioactivities of molecules with pharmacological and toxicological relevance". Comparative Biochemistry and Physiology Part - C: Toxicology and Pharmacology 197 (2017): 45-52. http://www.scopus.com/inward/record.url?eid=2-s2.0-85018759691&partnerID=MN8TOARS. Acesso aberto • Publicado • 10.1016/j.cbpc.2017.04.006 Tiago, D.M.; Conceição, N.; Caiado, H.; Laizé, V.; Cancela, M.L.. "Matrix Gla protein repression by MIR-155 promotes oncogenic signals in breast cancer MCF-7 cells". FEBS Letters 590 8 (2016): 1234-1241. http://www.scopus.com/inward/record.url?eid=2-s2.0-84962855726&partnerID=MN8TOARS. Acesso aberto • Publicado • 10.1002/1873-3468.12155 Rosa, J.; Tiago, D.M.; Marques, C.L.; Vijayakumar, P.; Fonseca, L.; Cancela, M.L.; Laizé, V.; et al. "Central role of betaine-homocysteine S-methyltransferase 3 in chondral ossification and evidence for sub-functionalization in neoteleost fish". Biochimica et Biophysica Acta - General Subjects 1860 7 (2016): 1373-1387. http://www.scopus.com/inward/record.url?eid=2-s2.0-84964782089&partnerID=MN8TOARS. Acesso aberto • Publicado • 10.1016/j.bbagen.2016.03.034 Marques, C.L.; Fernández, I.; Viegas, M.N.; Cox, C.J.; Martel, P.; Rosa, J.; Cancela, M.L.; Laizé, V.. "Comparative analysis of zebrafish bone morphogenetic proteins 2, 4 and 16: Molecular and evolutionary perspectives". Cellular and Molecular Life Sciences 73 4 (2016): 841-857. http://www.scopus.com/inward/record.url?eid=2-s2.0-84957432211&partnerID=MN8TOARS. Acesso aberto • Publicado • 10.1007/s00018-015-2024-x Roberto, V.P.; Tiago, D.M.; Gautvik, K.; Cancela, M.L.. "Corrigendum to "Evidence for the conservation of miR-223 in zebrafish (Danio rerio): Implications for function" [Gene 566/1 (2015) 54-62], doi: 10.1016/j.gene.2015.04.022". Gene 576 1 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84949599702&partnerID=MN8TOARS. Publicado • 10.1016/j.gene.2015.10.001 Correia, E.; Conceição, N.; Cancela, M.L.; Belo, J.A.. "Matrix Gla protein expression pattern in the early avian embryo". International Journal of Developmental Biology 60 1-3 (2016): 71-76. http://www.scopus.com/inward/record.url?eid=2-s2.0-84960330410&partnerID=MN8TOARS. Acesso aberto • Publicado • 10.1387/ijdb.150365jb Adrião, A.; Conceição, N.; Cancela, M.L.; Adrião, Andreia Lúcia Gonçalves; Conceição, Natércia; Cancela, Leonor. "MEF2C orthologues from zebrafish: Evolution, expression and promoter regulation". Archives of Biochemistry and Biophysics 591 (2016): 43-56. http://www.scopus.com/inward/record.url?eid=2-s2.0-84952359771&partnerID=MN8TOARS. Acesso aberto • Publicado • 10.1016/j.abb.2015.12.004 Bensimon-Brito, A.; Cardeira, J.; Dionísio, G.; Huysseune, A.; Cancela, M.L.; Witten, P.E.. "Revisiting in vivo staining with alizarin red S - A valuable approach to analyse zebrafish skeletal mineralization during development and regeneration". BMC Developmental Biology 16 1 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84954516804&partnerID=MN8TOARS. Acesso aberto • Publicado • 10.1186/s12861-016-0102-4 Medeiros, M.C.R.; Mestre, A.; Inácio, P.; Asgarif, S.; Araújo, I.M.; Hubbard, P.C.; Velez, Z.; et al. "An electrical method to measure low-frequency collective and synchronized cell activity using extracellular electrodes". Sensing and Bio-Sensing Research 10 (2016): 1-8. http://www.scopus.com/inward/record.url?eid=2-s2.0-84977507609&partnerID=MN8TOARS. Acesso aberto • Publicado • 10.1016/j.sbsr.2016.06.002 Marques, C.L.; Cancela, M.L.; Laizé, V.. "Transcriptional regulation of gilthead seabream bone morphogenetic protein (BMP) 2 gene by bone- and cartilage-related transcription factors". Gene 576 1 (2016): 229-236. http://www.scopus.com/inward/record.url?eid=2-s2.0-84979859596&partnerID=MN8TOARS. Acesso aberto • Publicado • 10.1016/j.gene.2015.10.005 Cardeira, J.; Gavaia, P.J.; Fernández, I.; Cengiz, I.F.; Moreira-Silva, J.; Oliveira, J.M.; Reis, R.L.; Cancela, M.L.; Laizé, V.. "Quantitative assessment of the regenerative and mineralogenic performances of the zebrafish caudal fin". Scientific Reports 6 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-85006713658&partnerID=MN8TOARS. Acesso aberto • Publicado • 10.1038/srep39191 Silva, I. A. L.; Michou, L.; Cancela, M. Leonor; Conceição, Natércia; Cancela, M. L.; Conceicao, N.. "Functional study of OPTN promoter: new OPTN regulators and effect of genetic variants". European Journal of Clinical Investigation 46 (2016): 124-124. http://hdl.handle.net/10400.1/9534. Publicado Vitorino, M.; Conceicao, N.; Adrião, Andreia Lúcia Gonçalves; Cancela, M. Leonor; Adriao, A.; Cancela, M. L.. "Zebrafish as a disease model for studying human Rett Syndrome". P1 (2016): 18. http://hdl.handle.net/10400.1/9535. Shapouri, M.; Cancela, Leonor; Iepure, S.; Stigter, T.; Ribeiro, L.; Silva, A.. "The variation of stygofauna along a gradient of salinization in a coastal aquifer". (2016): http://hdl.handle.net/10400.1/9760. 10.2166/nh.2015.153 Diogo, Patricia; Eufrásio, Ana; Martins, Gil; Cardeira, João; Cancela, M. Leonor; Cabrita, Elsa; Gavaia, Paulo. "Analysis of sperm quality in a type I diabetes zebrafish model". (2016): http://hdl.handle.net/10400.1/9252. Camacho, A.; F. Simao, Marcio; Ea, H. -K.; Cohen-Solal, M.; Richette, P.; Branco, J.; Cancela, Leonor; et al. "Iron overload in a murine model of hereditary hemochromatosis is associated with accelerated progression of osteoarthritis under mechanical stress". Osteoarthritis and Cartilage 24 3 (2016): 494-502. http://hdl.handle.net/10400.1/9606. Publicado • https://doi.org/10.1016/j.joca.2015.09.007 Divisato, Giuseppina; Formicola, Daniela; Esposito, Teresa; Merlotti, Daniela; Pazzaglia, Laura; Del Fattore, Andrea; Siris, Ethel; et al. "ZNF687 Mutations in Severe Paget Disease of Bone Associated with Giant Cell Tumor". American Journal of Human Genetics 98 2 (2016): 275-286. http://hdl.handle.net/10400.1/9627. https://dx.doi.org/10.1016/j.ajhg.2015.12.016 Camacho, A.; Funck-Brentano, T.; Simão, M.; Cancela, L.; Ottaviani, S.; Cohen-Solal, M.; Richette, P.. "Effect of C282Y genotype on self-reported musculoskeletal complications in hereditary hemochromatosis". PLoS ONE 10 3 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84926443403&partnerID=MN8TOARS. Acesso aberto • Publicado • 10.1371/journal.pone.0122817 Simões, B.; Conceição, N.; Matias, A.C.; Bragança, J.; Kelsh, R.N.; Cancela, M.L.. "Molecular characterization of cbfß gene and identification of new transcription variants: Implications for function". Archives of Biochemistry and Biophysics 567 (2015): 1-12. http://www.scopus.com/inward/record.url?eid=2-s2.0-84921028563&partnerID=MN8TOARS. Acesso aberto • Publicado • 10.1016/j.abb.2014.12.023 Diogo, P.; Martins, G.; Gavaia, P.; Pinto, W.; Dias, J.; Cancela, L.; Martínez-Páramo, S.. "Assessment of nutritional supplementation in phospholipids on the reproductive performance of zebrafish, Danio rerio (Hamilton, 1822)". Journal of Applied Ichthyology 31 S1 (2015): 3-9. http://www.scopus.com/inward/record.url?eid=2-s2.0-84929172664&partnerID=MN8TOARS. Acesso aberto • Publicado • 10.1111/jai.12733 Rodrigues, E.T.; Pardal, M.Â.; Laizé, V.; Cancela, M.L.; Oliveira, P.J.; Serafim, T.L.. "Cardiomyocyte H9c2 cells present a valuable alternative to fish lethal testing for azoxystrobin". Environmental Pollution 206 (2015): 619-626. http://www.scopus.com/inward/record.url?eid=2-s2.0-84940421879&partnerID=MN8TOARS. Acesso aberto • Publicado • 10.1016/j.envpol.2015.08.026 Cardeira, J.; Mendes, A.C.; Pousão-Ferreira, P.; Cancela, M.L.; Gavaia, P.J.. "Micro-anatomical characterization of vertebral curvatures in Senegalese sole Solea senegalensis". Journal of Fish Biology 86 6 (2015): 1796-1810. http://www.scopus.com/inward/record.url?eid=2-s2.0-84930224873&partnerID=MN8TOARS. Acesso aberto • Publicado • 10.1111/jfb.12686 Roberto, V.P.; Tiago, D.M.; Gautvik, K.; Cancela, M.L.. "Evidence for the conservation of miR-223 in zebrafish (Danio rerio): Implications for function". Gene 566 1 (2015): 54-62. http://www.scopus.com/inward/record.url?eid=2-s2.0-84929291522&partnerID=MN8TOARS. Acesso aberto • Publicado • 10.1016/j.gene.2015.04.022 Fernández, I.; Vijayakumar, P.; Marques, C.; Cancela, M.L.; Gavaia, P.J.; Laizé, V.. "Zebrafish vitamin K epoxide reductases: expression in vivo, along extracellular matrix mineralization and under phylloquinone and warfarin in vitro exposure". Fish Physiology and Biochemistry 41 3 (2015): 745-759. http://www.scopus.com/inward/record.url?eid=2-s2.0-84939998188&partnerID=MN8TOARS. Acesso aberto • Publicado • 10.1007/s10695-015-0043-z Fazenda, C.; Conceição, N.; Cancela, M.L.. "Transcription factors from Sox family regulate expression of zebrafish Gla-rich protein 2 gene". Gene 572 1 (2015): 57-62. http://www.scopus.com/inward/record.url?eid=2-s2.0-84940609027&partnerID=MN8TOARS. Acesso aberto • Publicado • 10.1016/j.gene.2015.06.079 Witten, P.E.; Cancela, M.L.. "Fish skeletal biology and beyond". Journal of Applied Ichthyology 30 4 (2014): 597-599. http://www.scopus.com/inward/record.url?eid=2-s2.0-84904913975&partnerID=MN8TOARS. Acesso aberto • Publicado • 10.1111/jai.12506 Simões, B.; Conceição, N.; Kelsh, R.N.; Cancela, M.L.. "Identification of cis-regulatory elements in the upstream regions of zebrafish runx3 through in silico analysis: Implications for function". Journal of Applied Ichthyology 30 4 (2014): 661-670. http://www.scopus.com/inward/record.url?eid=2-s2.0-84904873107&partnerID=MN8TOARS. Acesso aberto • Publicado • 10.1111/jai.12536 Cancela, M.L.; Laizé, V.; Conceição, N.. "Matrix Gla protein and osteocalcin: From gene duplication to neofunctionalization". Archives of Biochemistry and Biophysics 561 (2014): 56-63. http://www.scopus.com/inward/record.url?eid=2-s2.0-84907897083&partnerID=MN8TOARS. Acesso aberto • Publicado • 10.1016/j.abb.2014.07.020 Tiago, D.M.; Marques, C.L.; Roberto, V.P.; Cancela, M.L.; Laizé, V.. "Mir-20a regulates in vitro mineralization and BMP signaling pathway by targeting BMP-2 transcript in fish". Archives of Biochemistry and Biophysics 543 (2014): 23-30. http://www.scopus.com/inward/record.url?eid=2-s2.0-84892628912&partnerID=MN8TOARS. Acesso aberto • Publicado • 10.1016/j.abb.2013.12.009 Silva, I.A.L.; Conceição, N.; Michou, L.; Cancela, M.L.. "Can zebrafish be a valid model to study Paget's disease of bone?". Journal of Applied Ichthyology 30 4 (2014): 678-688. http://www.scopus.com/inward/record.url?eid=2-s2.0-84904917147&partnerID=MN8TOARS. Acesso aberto • Publicado • 10.1111/jai.12523 Rosa, J.T.; Cancela, M.L.; Laizé, V.. "Ets1 regulates the transcription of a cartilage-specific S100 protein in gilthead seabream". Journal of Applied Ichthyology 30 4 (2014): 707-712. http://www.scopus.com/inward/record.url?eid=2-s2.0-84904861722&partnerID=MN8TOARS. Acesso aberto • Publicado • 10.1111/jai.12534 Silva, I.A.L.; Cox, C.J.; Leite, R.B.; Cancela, M.L.; Conceição, N.. "Evolutionary conservation of TFIIH subunits: Implications for the use of zebrafish as a model to study TFIIH function and regulation". Comparative Biochemistry and Physiology Part - B: Biochemistry and Molecular Biology 172-173 1 (2014): 9-20. http://www.scopus.com/inward/record.url?eid=2-s2.0-84899696368&partnerID=MN8TOARS. Acesso aberto • Publicado • 10.1016/j.cbpb.2014.03.007 Roberto, V.P.; Tiago, D.M.; Silva, I.A.; Cancela, M.L.. "MiR-29a is an enhancer of mineral deposition in bone-derived systems". Archives of biochemistry and biophysics 564 (2014): 173-183. http://www.scopus.com/inward/record.url?eid=2-s2.0-84908322815&partnerID=MN8TOARS. Acesso aberto • Publicado • 10.1016/j.abb.2014.09.006 Marques, C.L.; Fernández, I.; Rosa, J.; Viegas, M.N.; Cancela, M.L.; Laizé, V.. "Spatiotemporal expression and retinoic acid regulation of bone morphogenetic proteins 2, 4 and 16 in Senegalese sole". Journal of Applied Ichthyology 30 4 (2014): 713-720. http://www.scopus.com/inward/record.url?eid=2-s2.0-84904901749&partnerID=MN8TOARS. Acesso aberto • Publicado • 10.1111/jai.12539 Fernández, I.; Santos, A.; Cancela, M.L.; Laizé, V.; Gavaia, P.J.. "Warfarin, a potential pollutant in aquatic environment acting through Pxr signaling pathway and ¿-glutamyl carboxylation of vitamin K-dependent proteins". Environmental Pollution 194 (2014): 86-95. http://www.scopus.com/inward/record.url?eid=2-s2.0-84905499602&partnerID=MN8TOARS. Publicado • 10.1016/j.envpol.2014.07.015 Richard, N.; Fernández, I.; Wulff, T.; Hamre, K.; Cancela, L.; Conceição, L.E.C.; Gavaia, P.J.. "Dietary Supplementation with Vitamin K Affects Transcriptome and Proteome of Senegalese Sole, Improving Larval Performance and Quality". Marine Biotechnology 16 5 (2014): 522-537. http://www.scopus.com/inward/record.url?eid=2-s2.0-84907594688&partnerID=MN8TOARS. Acesso aberto • Publicado • 10.1007/s10126-014-9571-2 Laizé, V.; Gavaia, P.J.; Cancela, M.L.. "Fish: A suitable system to model human bone disorders and discover drugs with osteogenic or osteotoxic activities". Drug Discovery Today: Disease Models 13 (2014): 29-37. http://www.scopus.com/inward/record.url?eid=2-s2.0-84947487335&partnerID=MN8TOARS. Acesso aberto • Publicado • 10.1016/j.ddmod.2014.08.001 Cavaco, S.; Williamson, M.K.; Rosa, J.; Roberto, V.; Cordeiro, O.; Price, P.A.; Leonor Cancela, M.; et al. "Teleost fish osteocalcin 1 and 2 share the ability to bind the calcium mineral phase". Fish Physiology and Biochemistry 40 3 (2014): 731-738. http://www.scopus.com/inward/record.url?eid=2-s2.0-84900320561&partnerID=MN8TOARS. Acesso aberto • Publicado • 10.1007/s10695-013-9880-9 Fernández, I.; Tiago, D.M.; Laizé, V.; Leonor Cancela, M.; Gisbert, E.. "Retinoic acid differentially affects in vitro proliferation, differentiation and mineralization of two fish bone-derived cell lines: Different gene expression of nuclear receptors and ECM proteins". Journal of Steroid Biochemistry and Molecular Biology 140 (2014): 34-43. http://www.scopus.com/inward/record.url?eid=2-s2.0-84890275864&partnerID=MN8TOARS. Acesso aberto • Publicado • 10.1016/j.jsbmb.2013.11.012 Vijayakumar, P.; Laizé, V.; Cardeira, J.; Trindade, M.; Cancela, M.L.. "Development of an in vitro cell system from zebrafish suitable to study bone cell differentiation and extracellular matrix mineralization". Zebrafish 10 4 (2013): 500-509. http://www.scopus.com/inward/record.url?eid=2-s2.0-84888424652&partnerID=MN8TOARS. Acesso aberto • Publicado • 10.1089/zeb.2012.0833 Mira, S.; Arnaud-Haond, S.; Palma, L.; Cancela, M.L.; Beja, P.. "Large-scale population genetic structure in Bonelli's Eagle Aquila fasciata". Ibis 155 3 (2013): 485-498. http://www.scopus.com/inward/record.url?eid=2-s2.0-84879607242&partnerID=MN8TOARS. Publicado • 10.1111/ibi.12065 Leite, R.B.; Milan, M.; Coppe, A.; Bortoluzzi, S.; dos Anjos, A.; Reinhardt, R.; Saavedra, C.; et al. "MRNA-Seq and microarray development for the Grooved carpet shell clam, Ruditapes decussatus: A functional approach to unravel host -parasite interaction". BMC Genomics 14 1 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84886388970&partnerID=MN8TOARS. Acesso aberto • Publicado • 10.1186/1471-2164-14-741 Conceição, N.; Viegas, M.; Fidalgo, J.; Cancela, M.L.. "Development and characterization of Xl1, a Xenopus laevis chondrocyte-like cell culture". Molecular and Cellular Biochemistry 373 1-2 (2013): 41-51. http://www.scopus.com/inward/record.url?eid=2-s2.0-84871780280&partnerID=MN8TOARS. Acesso aberto • Publicado • 10.1007/s11010-012-1473-x Viegas, C.S.B.; Simes, D.C.; Williamson, M.K.; Cavaco, S.; Laizé, V.; Price, P.A.; Cancela, M.L.. "Sturgeon osteocalcin shares structural features with matrix Gla protein: Evolutionary relationship and functional implications". Journal of Biological Chemistry 288 39 (2013): 27801-27811. http://www.scopus.com/inward/record.url?eid=2-s2.0-84884788467&partnerID=MN8TOARS. Acesso aberto • Publicado • 10.1074/jbc.M113.450213 Adriao, A.; Conceicao, N.; Gavaia, P. J.; Cancela, M. L.; Conceição, N.; Gavaia, Paulo J.; Cancela, Leonor. "Zebrafish as a model to study craniofacial phenotypes related to human MEF2Cmutations". European Journal of Clinical Investigation 43 (2013): 102-102. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000317141000294&KeyUID=WOS:000317141000294. Acesso aberto • Publicado Silva, I. A. L.; Conceicao, N.; Michou, L.; Cancela, M. L.. "Genetic variation in pdb6 locus and Paget's disease of bone". European Journal of Clinical Investigation 43 (2013): 81-81. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000317141000235&KeyUID=WOS:000317141000235. Acesso aberto • Publicado Araujo, Nuna C. P.; Afonso, Ricardo; Bringela, A.; Cancela, Leonor; Cristiano, Maria Lurdes Santos; Leite, Ricardo; Araujo, N.C.P.; et al. "Peroxides with antiplasmodial activity inhibit proliferation of Perkinsus olseni, the causative agent of Perkinsosis in bivalves". Parasitology International 62 6 (2013): 575-582. http://hdl.handle.net/10400.1/3392. http://dx.doi.org/10.1016/j.parint.2013.06.010 Conceição, N.; Fazenda, C.; Cancela, M.L.. "Comparative gene promoter analysis: An in silico strategy to identify candidate regulatory factors for Gla Rich Protein". Journal of Applied Ichthyology 28 3 (2012): 372-376. http://www.scopus.com/inward/record.url?eid=2-s2.0-84861309532&partnerID=MN8TOARS. Acesso aberto • Publicado • 10.1111/j.1439-0426.2012.02001.x Cardeira, J.; Bensimon-Brito, A.; Pousão-Ferreira, P.; Cancela, M.L.; Gavaia, P.J.. "Lordotic-kyphotic vertebrae develop ectopic cartilage-like tissue in Senegalese sole (Solea senegalensis)". Journal of Applied Ichthyology 28 3 (2012): 460-463. http://www.scopus.com/inward/record.url?eid=2-s2.0-84861328699&partnerID=MN8TOARS. Acesso aberto • Publicado • 10.1111/j.1439-0426.2012.01978.x Fazenda, C.; Silva, I.A.L.; Cancela, M.L.; Conceição, N.. "Molecular characterization of two paralog genes encoding Gla-rich protein (Grp) in zebrafish". Journal of Applied Ichthyology 28 3 (2012): 377-381. http://www.scopus.com/inward/record.url?eid=2-s2.0-84861317124&partnerID=MN8TOARS. Acesso aberto • Publicado • 10.1111/j.1439-0426.2012.02004.x Silva, I.A.L.; Cancela, M.L.; Conceição, N.. "Molecular cloning and expression analysis of XPD from zebrafish (Danio rerio)". Molecular Biology Reports 39 5 (2012): 5339-5348. http://www.scopus.com/inward/record.url?eid=2-s2.0-84863748620&partnerID=MN8TOARS. Acesso aberto • Publicado • 10.1007/s11033-011-1333-x Cardeira, J.; Vallés, R.; Dionísio, G.; Estévez, A.; Gisbert, E.; Pousão-Ferreira, P.; Cancela, M.L.; Gavaia, P.J.. "Osteology of the axial and appendicular skeletons of the meagre Argyrosomus regius (Sciaenidae) and early skeletal development at two rearing facilities". Journal of Applied Ichthyology 28 3 (2012): 464-470. http://www.scopus.com/inward/record.url?eid=2-s2.0-84861308997&partnerID=MN8TOARS. Acesso aberto • Publicado • 10.1111/j.1439-0426.2012.01979.x Bensimon-Brito, A.; Cardeira, J.; Cancela, M.L.; Huysseune, A.; Witten, P.E.. "Distinct patterns of notochord mineralization in zebrafish coincide with the localization of Osteocalcin isoform 1 during early vertebral centra formation". BMC Developmental Biology 12 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84867115368&partnerID=MN8TOARS. Acesso aberto • Publicado • 10.1186/1471-213X-12-28 Dionísio, G.; Campos, C.; Valente, L.M.P.; Conceição, L.E.C.; Cancela, M.L.; Gavaia, P.J.. "Effect of egg incubation temperature on the occurrence of skeletal deformities in Solea senegalensis". Journal of Applied Ichthyology 28 3 (2012): 471-476. http://www.scopus.com/inward/record.url?eid=2-s2.0-84861312186&partnerID=MN8TOARS. Publicado • 10.1111/j.1439-0426.2012.01996.x Rafael, M.S.; Laizé, V.; Bensimon-Brito, A.; Leite, R.B.; Schüle, R.; Cancela, M.L.. "Four-and-a-half LIM domains protein 2 (FHL2) is associated with the development of craniofacial musculature in the teleost fish Sparus aurata". Cellular and Molecular Life Sciences 69 3 (2012): 423-434. http://www.scopus.com/inward/record.url?eid=2-s2.0-84856224817&partnerID=MN8TOARS. Acesso aberto • Publicado • 10.1007/s00018-011-0754-y Michou, L.; Conceição, N.; Morissette, J.; Gagnon, E.; Miltenberger-Miltenyi, G.; Siris, E.S.; Brown, J.P.; Cancela, M.L.. "Genetic association study of UCMA/GRP and OPTN genes (PDB6 locus) with Paget's disease of bone". Bone 51 4 (2012): 720-728. http://www.scopus.com/inward/record.url?eid=2-s2.0-84865636771&partnerID=MN8TOARS. Acesso aberto • Publicado • 10.1016/j.bone.2012.06.028 Rafael, M.S.; Laizé, V.; Florindo, C.; Ferraresso, S.; Bargelloni, L.; Cancela, M.L.. "Overexpression of four and a half LIM domains protein 2 promotes epithelial-mesenchymal transition-like phenotype in fish pre-osteoblasts". Biochimie 94 5 (2012): 1128-1134. http://www.scopus.com/inward/record.url?eid=2-s2.0-84859426121&partnerID=MN8TOARS. Acesso aberto • Publicado • 10.1016/j.biochi.2012.01.013 Viegas, M.N.; Dias, J.; Cancela, M.L.; Laizé, V.. "Polyunsaturated fatty acids regulate cell proliferation, extracellular matrix mineralization and gene expression in a gilthead seabream skeletal cell line". Journal of Applied Ichthyology 28 3 (2012): 427-432. http://www.scopus.com/inward/record.url?eid=2-s2.0-84861319375&partnerID=MN8TOARS. Acesso aberto • Publicado • 10.1111/j.1439-0426.2012.01994.x Bensimon-Brito, A.; Cancela, M.L.; Huysseune, A.; Witten, P.E.. "Vestiges, rudiments and fusion events: The zebrafish caudal fin endoskeleton in an evo-devo perspective". Evolution and Development 14 1 (2012): 116-127. http://www.scopus.com/inward/record.url?eid=2-s2.0-84858079912&partnerID=MN8TOARS. Acesso aberto • Publicado • 10.1111/j.1525-142X.2011.00526.x Rosa, J. T.; Cancela, M. L.; Laize, V.. "Identification of novel molecular determinants of tissue mineralization in fish". Febs Journal 279 (2012): 538-539. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000308128602753&KeyUID=WOS:000308128602753. Acesso aberto • Publicado Parameswaran, V.; Laizé, V.; Gavaia, P.J.; Leonor Cancela, M.. "ESSA1 embryonic stem like cells from gilthead seabream: A new tool to study mesenchymal cell lineage differentiation in fish". Differentiation 84 3 (2012): 240-251. http://www.scopus.com/inward/record.url?eid=2-s2.0-84864956867&partnerID=MN8TOARS. Publicado • 10.1016/j.diff.2012.07.004 Leonor Cancela, M.; Conceição, N.; Laizé, V.; Cancela, M. L.; Conceicao, N.; Laize, V.. "Gla-rich protein, a new player in tissue calcification?". Advances in Nutrition 3 2 (2012): 174-181. http://www.scopus.com/inward/record.url?eid=2-s2.0-84861321582&partnerID=MN8TOARS. Acesso aberto • Publicado • 10.3945/an.111.001685 Eckhard Witten, P.; Leonor Cancela, M.. "Interdisciplinary approaches in fish skeletal biology". Journal of Applied Ichthyology 28 3 (2012): 297-299. http://www.scopus.com/inward/record.url?eid=2-s2.0-84861313151&partnerID=MN8TOARS. Publicado • 10.1111/j.1439-0426.2012.02015.x Fonseca, V.G.; Rosa, J.; Laizé, V.; Gavaia, P.J.; Cancela, M.L.. "Identification of a new cartilage-specific S100-like protein up-regulated during endo/perichondral mineralization in gilthead seabream". Gene Expression Patterns 11 7 (2011): 448-455. http://www.scopus.com/inward/record.url?eid=2-s2.0-80052166640&partnerID=MN8TOARS. Acesso aberto • Publicado • 10.1016/j.gep.2011.07.003 Tiago, D.M.; Cancela, M.L.; Laizé, V.. "Proliferative and mineralogenic effects of insulin, IGF-1, and vanadate in fish osteoblast-like cells". Journal of Bone and Mineral Metabolism 29 3 (2011): 377-382. http://www.scopus.com/inward/record.url?eid=2-s2.0-79959967407&partnerID=MN8TOARS. Acesso aberto • Publicado • 10.1007/s00774-010-0243-7 Sousa, S.; Afonso, N.; Bensimon-Brito, A.; Fonseca, M.; Simões, M.; Leon, J.; Roehl, H.; Cancela, M.L.; Jacinto, A.. "Differentiated skeletal cells contribute to blastema formation during zebrafish fin regeneration". Development 138 18 (2011): 3897-3905. http://www.scopus.com/inward/record.url?eid=2-s2.0-80051949501&partnerID=MN8TOARS. Acesso aberto • Publicado • 10.1242/dev.064717 Milan, Massimo; Coppe, Alessandro; Reinhardt, Richard; Cancela, Leonor; Leite, Ricardo B.; Saavedra, Carlos; Ciofi, Claudio; et al. "Transcriptome sequencing and microarray development for the Manila clam, Ruditapes philippinarum: genomic tools for environmental monitoring". BMC Genomics 12 1 (2011): 234. http://hdl.handle.net/10400.1/210. Publicado • http://dx.doi.org/10.1186/1471-2164-12-234 Tiago, Daniel; Laizé, Vincent; Bargelloni, Luca; Ferraresso, Serena; Romualdi, Chiara; Cancela, Leonor; Tiago, D.M.; et al. "Global analysis of gene expression in mineralizing fish vertebra-derived cell lines: new insights into anti-mineralogenic effect of vanadate". BMC Genomics 12 (2011): http://hdl.handle.net/10400.1/214. Publicado • http://dx.doi.org/10.1186/1471-2164-12-310 Fazenda, C.; Simões, B.; Kelsh, R.N.; Cancela, M.L.; Conceição, N.. "Dual transcriptional regulation by runx2 of matrix Gla protein in Xenopus laevis". Gene 450 1-2 (2010): 94-102. http://www.scopus.com/inward/record.url?eid=2-s2.0-72449139979&partnerID=MN8TOARS. Acesso aberto • Publicado • 10.1016/j.gene.2009.10.007 Viegas, C.S.B.; Conceiçao, N.; Fazenda, C.; Simes, D.C.; Cancela, M.L.. "Expression of Gla-rich protein (GRP) in newly developed cartilage-derived cell cultures from sturgeon (Acipenser naccarii)". Journal of Applied Ichthyology 26 2 (2010): 214-218. http://www.scopus.com/inward/record.url?eid=2-s2.0-77954186984&partnerID=MN8TOARS. Acesso aberto • Publicado • 10.1111/j.1439-0426.2010.01408.x Rafael, M.S.; Marques, C.L.; Parameswaran, V.; Cancela, M.L.; Laizé, V.. "Fish bone-derived cell lines: An alternative in vitro cell system to study bone biology". Journal of Applied Ichthyology 26 2 (2010): 230-234. http://www.scopus.com/inward/record.url?eid=2-s2.0-77954202980&partnerID=MN8TOARS. Acesso aberto • Publicado • 10.1111/j.1439-0426.2010.01411.x Louro, B.; Passos, A.L.S.; Souche, E.L.; Tsigenopoulos, C.; Beck, A.; Lagnel, J.; Bonhomme, F.; et al. "Gilthead sea bream (Sparus auratus) and European sea bass (Dicentrarchus labrax) expressed sequence tags: Characterization, tissue-specific expression and gene markers". Marine Genomics 3 3-4 (2010): 179-191. http://www.scopus.com/inward/record.url?eid=2-s2.0-78649495378&partnerID=MN8TOARS. Acesso aberto • Publicado • 10.1016/j.margen.2010.09.005 Cancela, M.L.; Witten, P.E.. "Advances in skeletal biology by understanding the fish skeleton: A multidisciplinary challenge". Journal of Applied Ichthyology 26 2 (2010): http://www.scopus.com/inward/record.url?eid=2-s2.0-77954184002&partnerID=MN8TOARS. Acesso aberto • Publicado • 10.1111/j.1439-0426.2010.01393.x Simão, M.F.; Leite, R.B.; Rocha, C.; Cancela, M.L.. "Changes in bioturbation of iron biogeochemistry and in molecular response of the clam ruditapes decussates upon perkinsus olseni infection". Archives of Environmental Contamination and Toxicology 59 3 (2010): 433-443. http://www.scopus.com/inward/record.url?eid=2-s2.0-77957969737&partnerID=MN8TOARS. Acesso aberto • Publicado • 10.1007/s00244-010-9490-9 Conceição, N.; Cox, C.J.; Simões, B.; Viegas, M.; Cancela, M.L.. "Comparative promoter analysis and its application to the identification of candidate regulatory factors of cartilage-expressed genes". Journal of Applied Ichthyology 26 2 (2010): 245-250. http://www.scopus.com/inward/record.url?eid=2-s2.0-77954196316&partnerID=MN8TOARS. Acesso aberto • Publicado • 10.1111/j.1439-0426.2010.01415.x Rosa, J.; Tiago, D.M.; Dias, J.; Cancela, M.L.; Laizé, V.. "Serum-specific stimulation of proliferation and mineralization of fish bone-derived cells". Journal of Applied Ichthyology 26 2 (2010): 251-256. http://www.scopus.com/inward/record.url?eid=2-s2.0-77954211691&partnerID=MN8TOARS. Acesso aberto • Publicado • 10.1111/j.1439-0426.2010.01414.x Bensimon-Brito, A.; Cancela, M.L.; Huysseune, A.; Witten, P.E.. "The zebrafish (Danio rerio) caudal complex - a model to study vertebral body fusion". Journal of Applied Ichthyology 26 2 (2010): 235-238. http://www.scopus.com/inward/record.url?eid=2-s2.0-77954185246&partnerID=MN8TOARS. Acesso aberto • Publicado • 10.1111/j.1439-0426.2010.01412.x Rafael, S. M.; Laize, V.; Schule, R.; Cancela, M. L.. "Fish as a suitable model to unveil the function of the four and half LIM domains protein 2". Febs Journal 277 (2010): 183-183. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000278565100642&KeyUID=WOS:000278565100642. Acesso aberto • Publicado Leite, R. B.; Cancela, M. L.. "Changes at transcriptome level during host-parasite interaction using Perkinsus olseni as a model". Febs Journal 277 (2010): 118-118. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000278565100422&KeyUID=WOS:000278565100422. Acesso aberto • Publicado Gavaia, Paulo Jorge; Domingues, Susana; Engrola, Sofia; Drake, Pilar; Sarasquete, Carmen; Dinis, M Teresa; Cancela, M Leonor; et al. "Comparing skeletal development of wild and hatchery-reared Senegalese sole (Solea senegalensis, Kaup 1858): evaluation in larval and postlarval stages". Aquaculture Research 40 14 (2009): 1585-1593. http://dx.doi.org/10.1111/j.1365-2109.2009.02258.x. Acesso aberto • Publicado • 10.1111/j.1365-2109.2009.02258.x Ascenso, R.M.T.; Leite, R.B.; Afonso, R.; Cancela, M.L.. "Expression pattern of Perkinsus olseni genes in response to bivalves with different susceptibility to perkinsosis". Journal of Fish Diseases 32 7 (2009): 633-636. http://www.scopus.com/inward/record.url?eid=2-s2.0-67650803089&partnerID=MN8TOARS. Acesso aberto • Publicado • 10.1111/j.1365-2761.2009.01039.x Viegas, C.S.B.; Cavaco, S.; Neves, P.L.; Ferreira, A.; João, A.; Williamson, M.K.; Price, P.A.; Cancela, M.L.; Simes, D.C.. "Gla-rich protein is a novel vitamin K-dependent protein present in serum that accumulates at sites of pathological calcifications". American Journal of Pathology 175 6 (2009): 2288-2298. http://www.scopus.com/inward/record.url?eid=2-s2.0-73549121071&partnerID=MN8TOARS. Acesso aberto • Publicado • 10.2353/ajpath.2009.090474 Roberto, V.; Cavaco, S.; Viegas, C. S. B.; Simes, Dina; Ortiz-Delgado, J. B.; Sarasquete, C.; Gavaia, Paulo J.; et al. "Matrix gla protein in turbot (Scophthalmus maximus): gene expression analysis and identification of sites of protein accumulation". Aquaculture 294 3-4 (2009): 202-211. http://hdl.handle.net/10400.1/4184. Publicado • http://dx.doi.org/10.1016/j.aquaculture.2009.06.020 Marques, C. L.; Rafael, M. S.; Tiago, Daniel M.; Cancela, Leonor; Laizé, Vincent. "Desenvolvimento de sistemas celulares de peixe adequados ao estudo da mineralização in vitro". CanalBQ (2009): 15-20. http://hdl.handle.net/10400.1/4289. Acesso aberto • Publicado Laizé, Vincent; Tiago, Daniel; Aureliano, M.; Cancela, Leonor; Laizé, V.; Tiago, D.M.; Cancela, M.L.. "New insights into mineralogenic effects of vanadate". Cellular and Molecular Life Sciences 66 24 (2009): 3831-3836. http://hdl.handle.net/10400.1/1360. Publicado • 10.1007/s00018-009-0137-9 Leite, R.B.; Brito, A.B.; Cancela, M.L.. "An Oxygen Molecular Sensor, the HIF Prolyl 4-Hydroxylase, in the Marine Protist Perkinsus olseni". Protist 159 3 (2008): 355-368. http://www.scopus.com/inward/record.url?eid=2-s2.0-45549106156&partnerID=MN8TOARS. Acesso aberto • Publicado • 10.1016/j.protis.2008.03.002 Elandalloussi, L.M.; Leite, R.B.; Rodrigues, P.M.; Afonso, R.; Cancela, M.L.. "Effect of the herbicide Roundup® on Perkinsus olseni in vitro proliferation and in vivo survival when infecting a permissive host, the clam Ruditapes decussatus". Bulletin of Environmental Contamination and Toxicology 80 6 (2008): 512-515. http://www.scopus.com/inward/record.url?eid=2-s2.0-46249130791&partnerID=MN8TOARS. Acesso aberto • Publicado • 10.1007/s00128-008-9412-y Viegas, C.S.B.; Simes, D.C.; Laizé, V.; Williamson, M.K.; Price, P.A.; Cancela, M.L.; S B Viegas, Carla; et al. "Gla-rich protein (GRP), a new vitamin K-dependent protein identified from sturgeon cartilage and highly conserved in vertebrates". Journal of Biological Chemistry 283 52 (2008): 36655-36664. http://www.scopus.com/inward/record.url?eid=2-s2.0-61349170719&partnerID=MN8TOARS. Acesso aberto • Publicado • 10.1074/jbc.M802761200 Tiago, D.M.; Laizé, V.; Cancela, M.L.; Aureliano, M.. "Impairment of mineralization by metavanadate and decavanadate solutions in a fish bone-derived cell line". Cell Biology and Toxicology 24 3 (2008): 253-263. http://www.scopus.com/inward/record.url?eid=2-s2.0-42549166545&partnerID=MN8TOARS. Acesso aberto • Publicado • 10.1007/s10565-007-9034-x Tiago, D.M.; Laizé, V.; Cancela, M.L.. "Alternatively spliced transcripts of Sparus aurata insulin-like growth factor 1 are differentially expressed in adult tissues and during early development". General and Comparative Endocrinology 157 2 (2008): 107-115. http://www.scopus.com/inward/record.url?eid=2-s2.0-44849127081&partnerID=MN8TOARS. Acesso aberto • Publicado • 10.1016/j.ygcen.2008.04.006 Tanguy, A.; Bierne, N.; Saavedra, C.; Pina, B.; Bachère, E.; Kube, M.; Bazin, E.; et al. "Increasing genomic information in bivalves through new EST collections in four species: Development of new genetic markers for environmental studies and genome evolution". Gene 408 1-2 (2008): 27-36. http://www.scopus.com/inward/record.url?eid=2-s2.0-37549048659&partnerID=MN8TOARS. Acesso aberto • Publicado • 10.1016/j.gene.2007.10.021 Coesel, S.N.; Baumgartner, A.C.; Teles, L.M.; Ramos, A.A.; Henriques, N.M.; Cancela, L.; Varela, J.C.S.. "Nutrient limitation is the main regulatory factor for carotenoid accumulation and for Psy and Pds steady state transcript levels in Dunaliella salina (Chlorophyta) exposed to high light and salt stress". Marine Biotechnology 10 5 (2008): 602-611. http://www.scopus.com/inward/record.url?eid=2-s2.0-49349108166&partnerID=MN8TOARS. Acesso aberto • 10.1007/s10126-008-9100-2 Conceição, N.; Laizé, V.; Simões, B.; Pombinho, A.R.; Cancela, M.L.. "Retinoic acid is a negative regulator of matrix Gla protein gene expression in teleost fish Sparus aurata". Biochimica et Biophysica Acta - Gene Regulatory Mechanisms 1779 1 (2008): 28-39. http://www.scopus.com/inward/record.url?eid=2-s2.0-39449109869&partnerID=MN8TOARS. Acesso aberto • Publicado • 10.1016/j.bbagrm.2007.11.003 Tiago, D.M.; Cancela, M.L.; Aureliano, M.; Laizé, V.. "Vanadate proliferative and anti-mineralogenic effects are mediated by MAPK and PI-3K/Ras/Erk pathways in a fish chondrocyte cell line". FEBS Letters 582 9 (2008): 1381-1385. http://www.scopus.com/inward/record.url?eid=2-s2.0-41449118290&partnerID=MN8TOARS. Acesso aberto • Publicado • 10.1016/j.febslet.2008.03.025 Tiago, Daniel; Cancela, Leonor; Aureliano, M.; Laizé, Vincent. "Vanadate proliferative and anti-mineralogic effects are mediated by MAPK and PI-3K/Ras/Erk pathways in a fish chondrocyte cell line". (2008): http://hdl.handle.net/10400.1/1359. Tiago, Daniel; Laizé, Vincent; Cancela, Leonor; Aureliano, M.. "Impairment of mineralization by metavanadate and decavanadate solutions in a fish bone-derived cell line". (2008): http://hdl.handle.net/10400.1/4707. http://dx.doi.org/10.1007/s10565-007-9034-x Tiago, Daniel; Laizé, Vincent; Cancela, Leonor; Aureliano, M.. "Impairment of mineralization by metavanadate and decavanadate solutions in a fish bone-derived cell line". (2008): http://hdl.handle.net/10400.1/1361. Fonseca, P. J.; Serrão, Ester; Pina-Martins, F.; Silva, P.; Mira, Sara; Quartau, J. A.; Paulo, O. S.; et al. "The evolution of Cicada songs contrasted with the relationships inferred from mitochondrial DNA (Insecta, hemiptera)". Bioacoustics 18 1 (2008): 17-34. http://hdl.handle.net/10400.1/4213. Publicado • http://dx.doi.org/ 10.1080/09524622.2008.9753588 Kohli, V.; Robles, V.; Cancela, M.L.; Acker, J.P.; Waskiewicz, A.J.; Elezzabi, A.Y.. "An alternative method for delivering exogenous material into developing zebrafish embryos". Biotechnology and Bioengineering 98 6 (2007): 1230-1241. http://www.scopus.com/inward/record.url?eid=2-s2.0-36749097906&partnerID=MN8TOARS. 10.1002/bit.21564 Fonseca, V.G.; Laizé, V.; Valente, M.S.; Cancela, M.L.. "Identification of an osteopontin-like protein in fish associated with mineral formation". FEBS Journal 274 17 (2007): 4428-4439. http://www.scopus.com/inward/record.url?eid=2-s2.0-34548141795&partnerID=MN8TOARS. Acesso aberto • Publicado • 10.1111/j.1742-4658.2007.05972.x Robles, V.; Cancela, M.L.. "Lipid-based transfection as a method for gene delivery in zebrafish (Danio rerio) embryos". Aquaculture Research 38 12 (2007): 1317-1322. http://www.scopus.com/inward/record.url?eid=2-s2.0-34548357269&partnerID=MN8TOARS. Publicado • 10.1111/j.1365-2109.2007.01806.x Rønnestad, I.; Gavaia, P.J.; Viegas, C.S.B.; Verri, T.; Romano, A.; Nilsen, T.O.; Jordal, A.-E.O.; Kamisaka, Y.; Cancela, M.L.. "Oligopeptide transporter PepT1 in Atlantic cod (Gadus morhua L.): Cloning, tissue expression and comparative aspects". Journal of Experimental Biology 210 22 (2007): 3883-3896. http://www.scopus.com/inward/record.url?eid=2-s2.0-37249063715&partnerID=MN8TOARS. Publicado • 10.1242/jeb.007898 Robles, V.; Barbosa, V.; Herráez, M.P.; Martínez-Páramo, S.; Cancela, M.L.. "The antifreeze protein type I (AFP I) increases seabream (Sparus aurata) embryos tolerance to low temperatures". Theriogenology 68 2 (2007): 284-289. http://www.scopus.com/inward/record.url?eid=2-s2.0-34250178781&partnerID=MN8TOARS. Publicado • 10.1016/j.theriogenology.2007.05.003 Marques, C. L.; Rafael, M. S.; Cancela, Leonor; Laizé, Vincent; Marques, C.L.; Rafael, M.S.; Cancela, M.L.; Laizé, V.. "Establishment of primary cell cultures from fish calcified tissues". Cytotechnology 55 1 (2007): 9-13. http://hdl.handle.net/10400.1/4334. http://dx.doi.org/10.1007/s10616-007-9098-8 Ortiz-Delgado, J.B.; Simes, D.C.; Viegas, C.S.B.; Schaff, B.J.; Sarasquete, C.; Cancela, M.L.. "Cloning of matrix Gla protein in a marine cartilaginous fish, Prionace glauca: Preferential protein accumulation in skeletal and vascular systems". Histochemistry and Cell Biology 126 1 (2006): 89-101. http://www.scopus.com/inward/record.url?eid=2-s2.0-33745063198&partnerID=MN8TOARS. Publicado • 10.1007/s00418-005-0125-6 Gavaia, P.J.; Simes, D.C.; Ortiz-Delgado, J.B.; Viegas, C.S.B.; Pinto, J.P.; Kelsh, R.N.; Sarasquete, M.C.; Cancela, M.L.. "Osteocalcin and matrix Gla protein in zebrafish (Danio rerio) and Senegal sole (Solea senegalensis): Comparative gene and protein expression during larval development through adulthood". Gene Expression Patterns 6 6 (2006): 637-652. http://www.scopus.com/inward/record.url?eid=2-s2.0-33646862665&partnerID=MN8TOARS. Publicado • 10.1016/j.modgep.2005.11.010 Braga, D.; Laizé, V.; Tiago, D.M.; Cancela, M.L.. "Enhanced DNA transfer into fish bone cells using polyethylenimine". Molecular Biotechnology 34 1 (2006): 51-54. http://www.scopus.com/inward/record.url?eid=2-s2.0-33748370298&partnerID=MN8TOARS. Publicado • 10.1385/MB:34:1:51 Simões, B.; Conceição, N.; Viegas, C.S.B.; Pinto, J.P.; Gavaia, P.J.; Hurst, L.D.; Kelsh, R.N.; Cancela, M.L.. "Identification of a promoter element within the Zebrafish colXa1 gene responsive to Runx2 isoforms Osf2/Cbfa1 and til-1 but not to pebp2aA2". Calcified Tissue International 79 4 (2006): 230-244. http://www.scopus.com/inward/record.url?eid=2-s2.0-33750561072&partnerID=MN8TOARS. Publicado • 10.1007/s00223-006-0111-6 Laizé, V.; Viegas, C.S.B.; Price, P.A.; Cancela, M.L.. "Identification of an osteocalcin isoform in fish with a large acidic prodomain". Journal of Biological Chemistry 281 22 (2006): 15037-15043. http://www.scopus.com/inward/record.url?eid=2-s2.0-33744965092&partnerID=MN8TOARS. Acesso aberto • Publicado • 10.1074/jbc.M600373200 Rafael, M.S.; Laizé, V.; Cancela, M.L.. "Identification of Sparus aurata bone morphogenetic protein 2: Molecular cloning, gene expression and in silico analysis of protein conserved features in vertebrates". Bone 39 6 (2006): 1373-1381. http://www.scopus.com/inward/record.url?eid=2-s2.0-35448991288&partnerID=MN8TOARS. Publicado • 10.1016/j.bone.2006.06.021 Rønnestad, I.; Gavaia, Paulo J.; Viegas, C. S. B.; Verri, T.; Cancela, Leonor. "PepT1 in a coldwater marine teleost larvae- Atlantic cod: cloning and preliminary studies of expression and phylogeny". Acta Bio Medica. 77 (2006): 82. http://hdl.handle.net/10400.1/4498. Publicado Engrola, S.; Conceição, L.E.C.; Gavaia, P.J.; Cancela, M.L.; Dinis, M.T.. "Effects of pre-weaning feeding frequency on growth, survival, and deformation of Senegalese sole, Solea senegalensis (Kaup, 1858)". Israeli Journal of Aquaculture - Bamidgeh 57 1 (2005): 10-18. http://www.scopus.com/inward/record.url?eid=2-s2.0-16344396118&partnerID=MN8TOARS. Laizé, V.; Pombinho, A.R.; Cancela, M.L.; Laizé, Vincent; Pombinho, A. R.; Cancela, Leonor. "Characterization of Sparus aurata osteonectin cDNA and in silico analysis of protein conserved features: Evidence for more than one osteonectin in Salmonidae". Biochimie 87 5 (2005): 411-420. http://www.scopus.com/inward/record.url?eid=2-s2.0-16844379888&partnerID=MN8TOARS. 10.1016/j.biochi.2005.01.008 Elandalloussi, L.M.; Leite, R.B.; Rodrigues, P.M.; Afonso, R.; Nunes, P.A.; Cancela, M.L.. "Effect of antiprotozoal drugs on the proliferation of the bivalve parasite Perkinsus olseni". Aquaculture 243 1-4 (2005): 9-17. http://www.scopus.com/inward/record.url?eid=2-s2.0-10644265408&partnerID=MN8TOARS. 10.1016/j.aquaculture.2004.09.038 Fonseca, V.G.; Lago-Lestón, A.; Laizé, V.; Cancela, M.L.; Fonseca, V. G.; Laizé, Vincent; Cancela, Leonor. "Rapid identification of differentially expressed genes by in situ screening of bacteria". Molecular Biotechnology 30 2 (2005): 163-165. http://www.scopus.com/inward/record.url?eid=2-s2.0-22344433118&partnerID=MN8TOARS. 10.1385/MB:30:2:163 Elandalloussi, L.M.; Rodrigues, P.M.; Afonso, R.; Leite, R.B.; Nunes, P.A.; Cancela, M.L.. "Shikimate and folate pathways in the protozoan parasite, Perkinsus olseni". Molecular and Biochemical Parasitology 142 1 (2005): 106-109. http://www.scopus.com/inward/record.url?eid=2-s2.0-19344373699&partnerID=MN8TOARS. 10.1016/j.molbiopara.2005.03.014 Frazão, C.; Simes, D.C.; Coelho, R.; Alves, D.; Williamson, M.K.; Price, P.A.; Cancela, M.L.; Carrondo, M.A.. "Structural evidence of a fourth Gla residue in fish osteocalcin: Biological implications". Biochemistry 44 4 (2005): 1234-1242. http://www.scopus.com/inward/record.url?eid=2-s2.0-13444271638&partnerID=MN8TOARS. 10.1021/bi048336z Conceição, N.; Silva, A.C.; Fidalgo, J.; Belo, J.A.; Cancela, M.L.. "Identification of alternative promoter usage for the matrix Gla protein gene: Evidence for differential expression during early development in Xenopus laevis". FEBS Journal 272 6 (2005): 1501-1510. http://www.scopus.com/inward/record.url?eid=2-s2.0-15944374190&partnerID=MN8TOARS. 10.1111/j.1742-4658.2005.04590.x Mira, S.; Wolff, K.; Cancela, M.L.. "Isolation and characterization of microsatellite markers in Bonelli's eagle (Hieraaetus fasciatus)". Molecular Ecology Notes 5 3 (2005): 493-495. http://www.scopus.com/inward/record.url?eid=2-s2.0-28344450284&partnerID=MN8TOARS. 10.1111/j.1471-8286.2005.00967.x Ortiz-Delgado, J. B.; Simes, Dina; Gavaia, Paulo J.; Sarasquete, C.; Cancela, Leonor; Ortiz-Delgado, J.B.; Simes, D.C.; Gavaia, P.; Cancela, M.L.. "Osteocalcin and Matrix Gla Protein in developing teleost teeth. Identification of sites of mRNA and protein accumulation at single cell resolution". Histochemistry and Cell Biology 124 2 (2005): 123-130. http://hdl.handle.net/10400.1/4508. http://dx.doi.org/10.1007/s00418-005-0015-y Laizé, Vincent; Martel, Paulo; Viegas, Carla; Price, P. A.; Cancela, Leonor; Laizé, V.; Martel, P.; et al. "Evolution of matrix and bone gamma-carboxyglutamic acid proteins in vertebrates". Journal of Biological Chemistry 280 29 (2005): 26659-26668. http://hdl.handle.net/10400.1/4282. http://dx.doi.org/ 10.1074/jbc.M500257200 Engrola, S.; Conceição, L. E. C.; Gavaia, Paulo J.; Cancela, Leonor; Dinis, Maria Teresa. "Effect of pre-weaning feeding regime on weaning performance of Senegalese sole, Solea senegalensis (Kaup, 1858)". Despite much interest in the production of Senegalese sole (Solea senegalensis) in southern Europe, weaning of this species onto artificial diets is problematic and varying results are obtained. The aim of this study was to test two feeding frequencies during a 13-day pre-weaning period and assess their impact on the growth and survival of Senegalese sole. Postlarvae were fed Artemia metanauplii w (2005): http://hdl.handle.net/10400.1/4483. Elandalloussi, L. M.; Rodrigues, Pedro; Afonso, R.; Leite, R. B.; Nunes, Patrícia A.; Cancela, Leonor. "Shikimate and folate pathways in the protozoan parasite, Perkinsus olseni". (2005): http://hdl.handle.net/10400.1/7217. https://dx.doi.org/10.1016/j.molbiopara.2005.03.014 Elandalloussi, Laurence M.; Leite, Ricardo B.; Rodrigues, Pedro; Afonso, Ricardo; Nunes, Patrícia A.; Cancela, Leonor. "Effect of antiprotozoal drugs on the proliferation of the bivalve parasite Perkinsus olseni". (2005): http://hdl.handle.net/10400.1/4402. http://dx.doi.org/10.1016/j.aquaculture.2004.09.038 Elandalloussi, Laurence M.; Rodrigues, Pedro; Afonso, Ricardo; Leite, Ricardo B.; Nunes, Patrícia A.; Cancela, Leonor. "Shikimate and folate pathways in the protozoan parasite, Perkinsus olseni". (2005): http://hdl.handle.net/10400.1/4362. http://dx.doi.org/10.1016/j.molbiopara.2005.03.014 Elandalloussi, L. M.; Leite, R. B.; Rodrigues, Pedro; Afonso, R.; Nunes, Patrícia A.; Cancela, Leonor. "Effect of antiprotozoal drugs on the proliferation of the bivalve parasite Perkinsus olseni". (2005): http://hdl.handle.net/10400.1/7218. https://dx.doi.org/10.1016/j.aquaculture.2004.09.038 Elandalloussi, L. M.; Rodrigues, Pedro; Afonso, R.; Leite, R. B.; Nunes, Patrícia A.; Cancela, Leonor. "Shikimate and folate pathways in the protozoan parasite, Perkinsus olseni". (2005): http://hdl.handle.net/10400.1/7217. https://dx.doi.org/10.1016/j.molbiopara.2005.03.014 Pinto, Jorge; Conceição, Natércia; S B Viegas, Carla; Leite, Ricardo; Hurst, L. D.; Kelsh, R. N.; Leonor Cancela, M.; et al. "Identification of a new pebp2 alpha A2 isoform from zebrafish runx2 capable of inducing osteocalcin gene expression in vitro". Journal of Bone and Mineral Research 20 8 (2005): 1440-1453. http://hdl.handle.net/10400.1/11176. 10.1359/JBMR.050318 Elandalloussi, Laurence M.; Leite, Ricardo B.; Rodrigues, Pedro; Afonso, Ricardo; Nunes, Patrícia A.; Cancela, Leonor. "Effect of antiprotozoal drugs on the proliferation of the bivalve parasite Perkinsus olseni". (2005): http://hdl.handle.net/10400.1/4402. http://dx.doi.org/10.1016/j.aquaculture.2004.09.038 Elworthy, S.; P Pinto, Jorge; Pettifer, A.; Leonor Cancela, M.; Kelsh, R. N.; Pinto, J.P.; Cancela, M.L.; Kelsh, R.N.. "Phox2b function in the enteric nervous system is conserved in zebrafish and is sox10-dependent". Mechanisms of Development 122 5 (2005): 659-669. http://hdl.handle.net/10400.1/11721. 10.1016/j.mod.2004.12.008 Elandalloussi, L. M.; Leite, R. B.; Rodrigues, Pedro; Afonso, R.; Nunes, Patrícia A.; Cancela, Leonor. "Effect of antiprotozoal drugs on the proliferation of the bivalve parasite Perkinsus olseni". (2005): http://hdl.handle.net/10400.1/7218. https://dx.doi.org/10.1016/j.aquaculture.2004.09.038 Elandalloussi, Laurence M.; Rodrigues, Pedro; Afonso, Ricardo; Leite, Ricardo B.; Nunes, Patrícia A.; Cancela, Leonor. "Shikimate and folate pathways in the protozoan parasite, Perkinsus olseni". (2005): http://hdl.handle.net/10400.1/4362. http://dx.doi.org/10.1016/j.molbiopara.2005.03.014 Simes, D.C.; Williamson, M.K.; Schaff, B.J.; Gavaia, P.J.; Ingleton, P.M.; Price, P.A.; Cancela, M.L.; et al. "Characterization of Osteocalcin (BGP) and Matrix Gla Protein (MGP) Fish Specific Antibodies: Validation for Immunodetection Studies in Lower Vertebrates". Calcified Tissue International 74 2 (2004): 170-180. http://www.scopus.com/inward/record.url?eid=2-s2.0-1342302340&partnerID=MN8TOARS. 10.1007/s00223-003-0079-4 Elandalloussi, L.M.; Leite, R.M.; Afonso, R.; Nunes, P.A.; Robledo, J.A.F.; Vasta, G.R.; Cancela, M.L.. "Development of a PCR-ELISA assay for diagnosis of Perkinsus marinus and Perkinsus atlanticus infections in bivalve molluscs". Molecular and Cellular Probes 18 2 (2004): 89-96. http://www.scopus.com/inward/record.url?eid=2-s2.0-1642502971&partnerID=MN8TOARS. 10.1016/j.mcp.2003.09.008 Streiff, R.; Mira, S.; Castro, M.; Cancela, M.L.. "Multiple paternity in Norway lobster (Nephrops norvegicus L.) assessed with microsatellite markers". Marine Biotechnology 6 1 (2004): 60-66. http://www.scopus.com/inward/record.url?eid=2-s2.0-1642264028&partnerID=MN8TOARS. 10.1007/s10126-003-0015-7 Leite, R.B.; Afonso, R.; Cancela, M.L.. "Perkinsus sp. infestation in carpet-shell clams, Ruditapes decussatus (L), along the Portuguese coast. Results from a 2-year survey". Aquaculture 240 1-4 (2004): 39-53. http://www.scopus.com/inward/record.url?eid=2-s2.0-4744368358&partnerID=MN8TOARS. 10.1016/j.aquaculture.2004.05.014 Elandalloussi, L. M.; Leite, R. M.; Afonso, R.; Nunes, Patrícia A.; Robledo, J. A. F.; Vasta, G. R.; Cancela, Leonor. "Development of a PCR-ELISA assay for diagnosis of Perkinsus marinus and Perkinsus atlanticus infections in bivalve molluscs". (2004): http://hdl.handle.net/10400.1/7219. https://dx.doi.org/10.1016/j.mcp.2003.09.008 Elandalloussi, L. M.; Leite, R. M.; Afonso, R.; Nunes, Patrícia A.; Robledo, J. A. F.; Vasta, G. R.; Cancela, Leonor. "Development of a PCR-ELISA assay for diagnosis of Perkinsus marinus and Perkinsus atlanticus infections in bivalve molluscs". (2004): http://hdl.handle.net/10400.1/7219. https://dx.doi.org/10.1016/j.mcp.2003.09.008 Pombinho, A. R.; Laizé, Vincent; Molha, D. M.; Marques, S.; Cancela, Leonor; Pombinho, A.R.; Laizé, V.; et al. "Development of two bone-derived cell lines from the marine teleost Sparus aurata; evidence for extracellular matrix mineralization and cell-type-specific expression of matrix Gla protein and osteocalcin". Cell and Tissue Research 315 3 (2004): 393-406. http://hdl.handle.net/10400.1/4299. http://doi:10.1152/ 10.1007/s00441-003-0830-1 Aurelle, D.; Guillemaud, T.; Afonso, P.; Morato, T.; Wirtz, P.; Serrão Santos, R.; Cancela, M.L.. "Genetic study of Coris julis (Osteichtyes, Perciformes, Labridae) evolutionary history and dispersal abilities". Comptes Rendus - Biologies 326 8 (2003): 771-785. http://www.scopus.com/inward/record.url?eid=2-s2.0-0142149228&partnerID=MN8TOARS. 10.1016/j.crvi.2003.08.001 Pinto, J.P.; Conceição, N.; Gavaia, P.J.; Cancela, M.L.. "Matrix Gla protein gene expression and protein accumulation colocalize with cartilage distribution during development of the teleost fish Sparus aurata". Bone 32 3 (2003): 201-210. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037347260&partnerID=MN8TOARS. 10.1016/S8756-3282(02)00981-X Simes, D.C.; Williamson, M.K.; Ortiz-Delgado, J.B.; Viegas, C.S.B.; Price, P.A.; Cancela, M.L.; Simes, DC; et al. "Purification of matrix Gla protein from a marine teleost fish, Argyrosomus regius: Calcified cartilage and not bone as the primary site of MGP accumulation in fish". Journal of Bone and Mineral Research 18 2 (2003): 244-259. http://www.scopus.com/inward/record.url?eid=2-s2.0-12244249480&partnerID=MN8TOARS. 10.1359/jbmr.2003.18.2.244 Elandalloussi, L. M.; Afonso, R.; Nunes, Patrícia A.; Cancela, Leonor; Elandalloussi, L.M.; Nunes, P.A.; Cancela, M.L.. "Effect of desferrioxamine and 2,2 '-bipyridyl on the proliferation of Perkinsus atlanticus". Biomolecular Engineering 20 4-6 (2003): 349-354. http://hdl.handle.net/10400.1/7220. https://dx.doi.org/10.1016/S1389-0344(03)00047-9 Pinto, J. P.; Conceição, N.; Gavaia, Paulo J.; Cancela, Leonor. "Matrix Gla protein gene expression and protein accumulation co-localize with cartilage distribution during development of the teleost fish Sparus aurata". (2003): http://hdl.handle.net/10400.1/4383. http://dx.doi.org/10.1016/S8756-3282(02)00981-X Pinto, J. P.; Conceição, N.; Gavaia, Paulo J.; Cancela, Leonor. "Matrix Gla protein gene expression and protein accumulation co-localize with cartilage distribution during development of the teleost fish Sparus aurata". (2003): http://hdl.handle.net/10400.1/4493. http://dx.doi.org/10.1016/S8756-3282(02)00981-X Leite, Ricardo B.; Rodrigues, Pedro; Elandalloussi, Laurence M.; Afonso, Ricardo; Nunes, Patrícia A.; Cancela, Leonor. "Perkinsus Atlanticus – desenvolvimento de um método de diagnóstico para detecção de infecção em moluscos bivalves". (2003): http://hdl.handle.net/10400.1/4335. Robledo, J.A.F.; Nunes, P.A.; Cancela, M.L.; Vasta, G.R.. "Development of an in vitro clonal culture and characterization of the rRNA gene cluster of Perkinsus atlanticus, a protistan parasite of the clam Tapes decussatus". Journal of Eukaryotic Microbiology 49 5 (2002): 414-422. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036710887&partnerID=MN8TOARS. Viegas, C.S.B.; Pinto, J.P.; Conceição, N.; Simes, D.C.; Cancela, M.L.. "Cloning and characterization of the cDNA and gene encoding Xenopus laevis osteocalcin". Gene 289 1-2 (2002): 97-107. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036572833&partnerID=MN8TOARS. 10.1016/S0378-1119(02)00480-8 Mira, S.; Billot, C.; Guillemaud, T.; Palma, L.; Cancela, M.L.. "Isolation and characterization of polymorphic microsatellite markers in Eurasian vulture Gyps fulvus". Molecular Ecology Notes 2 4 (2002): 557-558. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036899159&partnerID=MN8TOARS. 10.1046/j.1471-8286.2002.00314.x Conceição, N.; Henriques, N.M.; Ohresser, M.C.P.; Hublitz, P.; Schüle, R.; Cancela, M.L.. "Molecular cloning of the Matrix Gla Protein gene from Xenopus laevis: Functional analysis of the promoter identifies a calcium sensitive region required for basal activity". European Journal of Biochemistry 269 7 (2002): 1947-1956. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036231825&partnerID=MN8TOARS. 10.1046/j.1432-1327.2002.02846.x Gavaia, Paulo J.; Dinis, Maria Teresa; Cancela, Leonor; Gavaia, P.J.; Dinis, M.T.; Cancela, M.L.. "Osteological development and abnormalities of the vertebral column and caudal skeleton in larval and juvenile stages of hatchery-reared Senegal sole (Solea senegalensis)". Aquaculture 211 1-4 (2002): 305-323. http://hdl.handle.net/10400.1/4497. http://dx.doi.org/10.1016/S0044-8486(02)00167-9 Robledo, J. A. F.; Nunes, Patrícia A.; Cancela, Leonor; Vasta, G. R.. "Development of an in vitro clonal culture and characterization of the rRNA gene cluster of Perkinsus atlanticus, a protistan parasite of the clam Tapes decussatus". (2002): http://hdl.handle.net/10400.1/7221. https://dx.doi.org/10.1111/j.1550-7408.2002.tb00221.x Henriques, M.; Lourenco, R.; Almada, F.; Calado, G.; Goncalves, D.; Guillemaud, Thomas; Cancela, M. Leonor; et al. "A revision of the status of Lepadogaster lepadogaster (Teleostei : Gobiesocidae): sympatric subspecies or a long misunderstood blend of species?". Biological Journal of the Linnean Society 76 3 (2002): 327-338. http://hdl.handle.net/10400.1/11484. 10.1111/j.1095-8312.2002.tb01700.x Streiff, R.; Guillemaud, T.; Alberto, F.; Magalhães, J.; Castro, M.; Cancela, M.L.. "Isolation and characterization of microsatellite loci in the Norway lobster (Nephrops norvegicus)". Molecular Ecology Notes 1 1-2 (2001): 71-72. http://www.scopus.com/inward/record.url?eid=2-s2.0-0346342219&partnerID=MN8TOARS. Publicado Cancela, M.L.; Ohresser, M.C.P.; Reia, J.P.; Viegas, C.S.B.; Williamson, M.K.; Price, P.A.. "Matrix Gla protein in Xenopus laevis: Molecular cloning, tissue distribution, and evolutionary considerations". Journal of Bone and Mineral Research 16 9 (2001): 1611-1621. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034868048&partnerID=MN8TOARS. Publicado Palma, L.; Mira, S.; Cardia, P.; Beja, P.; Guillemaud, T.; Ferrand, N.; Cancela, M.L.; Da Fonseca, L.C.. "Sexing bonelli's eagle nestlings: Morphometrics versus molecular techniques". Journal of Raptor Research 35 3 (2001): 187-193. http://www.scopus.com/inward/record.url?eid=2-s2.0-16344361957&partnerID=MN8TOARS. Publicado Pinto, J.P.; Ohresser, M.C.P.; Cancela, M.L.. "Cloning of the bone Gla protein gene from the teleost fish Sparus aurata. Evidence for overall conservation in gene organization and bone-specific expression from fish to man". Gene 270 1-2 (2001): 77-91. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035972741&partnerID=MN8TOARS. 10.1016/S0378-1119(01)00426-7 Simes, Dina; Gavaia, Paulo J.; Ortiz-Delgado, J. B.; Pinto, J. P.; Cancela, Leonor. "Characterization of specific antibodies for fish osteocalcin and its usefulness to investigate osteocalcin tissue distribution in lower vertebrates.". Calcified Tisue International 74 (2001): 170-180. http://hdl.handle.net/10400.1/4426. Publicado Gavaia, Paulo J.; Viegas, C. A.; Pinto, J. P.; Sarasquete, C.; Cancela, Leonor. "Detection and localization of osteocalcin (BGP or Bone Gla Protein) in teleosts by in situ hybridization and immunohistochemistry". Bone 28 5 (2001): S103. http://hdl.handle.net/10400.1/4468. Publicado Pearson, G. A.; Serrão, Ester; Cancela, Leonor; Pearson, G.; Serrão, E.A.; Cancela, M.L.. "Suppression subtractive hybridization for studying gene expression during aerial exposure and desiccation in fucoid algae". European Journal of Phycology 36 4 (2001): 359-366. http://hdl.handle.net/10400.1/4061. Publicado • http://dx.doi.org/ 10.1080/09670260110001735508 Cancela, M. Leonor; Ohresser, M. C. P.; Reia, J. P.; S B Viegas, Carla; Williamson, M. K.; Price, P. A.. "Matrix gla protein in xenopus laevis: molecular cloning, tissue distribution, and evolutionary considerations". (2001): http://hdl.handle.net/10400.1/11930. 10.1359/jbmr.2001.16.9.1611 Gavaia, P.J.; Sarasquete, C.; Cancela, M.L.. "Detection of mineralized structures in early stages of development of marine Teleostei using a modified alcian blue-alizarin red double staining technique for bone and cartilage". Biotechnic and Histochemistry 75 2 (2000): 79-84. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033860776&partnerID=MN8TOARS. Publicado Guillemaud, T.; Cancela, M.L.; Afonso, P.; Morato, T.; Santos, R.S.; Wirtz, P.. "Molecular insights into the taxonomic status of Coris atlantica (Pisces: Labridae)". Journal of the Marine Biological Association of the United Kingdom 80 5 (2000): 929-933. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033671065&partnerID=MN8TOARS. Publicado • 10.1017/S0025315400002915 Guillemaud, T.; Almada, F.; Santos, R.S.; Cancela, M.L.. "Interspecific utility of microsatellites in fish: A case study of (CT)(n) and (GT)(n) markers in the shanny Lipophrys pholis (Pisces: Blenniidae) and their use in other blennioidei". Marine Biotechnology 2 3 (2000): 248-253. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034190159&partnerID=MN8TOARS. Publicado Carvalho, M.C.; Streiff, R.; Guillemaud, T.; Afonso, P.; Santos, R.S.; Cancela, M.L.. "Isolation and characterization of polymorphic microsatellite markers in Abudefduf luridus (Pisces: Pomacentridae)". Molecular Ecology 9 7 (2000): 993-994. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033911313&partnerID=MN8TOARS. Publicado • 10.1046/j.1365-294X.2000.00939.x Guillemaud, T.; Streiff, R.; Santos, R.S.; Afonso, P.; Morato, T.; Cancela, M.L.. "Microsatellite characterization in the rainbow wrasse Coris julis (Pisces: Labridae)". Molecular Ecology 9 5 (2000): 631-632. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034060782&partnerID=MN8TOARS. 10.1046/j.1365-294X.2000.00882-1.x Cancela, M.L.; Hu, B.; Price, P.A.. "Effect of cell density and growth factors on matrix GLA protein expression by normal rat kidney cells". Journal of Cellular Physiology 171 2 (1997): 125-134. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030974786&partnerID=MN8TOARS. Publicado • 10.1002/(SICI)1097-4652(199705)171:2<125::AID-JCP2>3.0.CO;2-Q Kirfel, J.; Kelter, M.; Cancela, L.M.; Price, P.A.; Schüle, R.. "Identification of a novel negative retinoic acid responsive element in the promoter of the human matrix Gla protein gene". Proceedings of the National Academy of Sciences of the United States of America 94 6 (1997): 2227-2232. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030992162&partnerID=MN8TOARS. Publicado • 10.1073/pnas.94.6.2227 Cancela, M.L.; Williamson, M.K.; Price, P.A.. "Amino-acid sequence of bone Gla protein from the African clawed toad Xenopus laevis and the fish Sparus aurata". International Journal of Peptide and Protein Research 46 5 (1995): 419-423. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028864789&partnerID=MN8TOARS. Publicado Cancela, M.L.; Williamson, M.K.; Price, P.A.. "The putative RGD-dependent cell adhesion activity of matrix Gla protein is due to higher molecular weight contaminants". Journal of Biological Chemistry 269 16 (1994): 12185-12189. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028233411&partnerID=MN8TOARS. Acesso aberto • Publicado Rannels, S.R.; Cancela, M.L.; Wolpert, E.B.; Price, P.A.. "Matrix Gla protein mRNA expression in cultured type II pneumocytes". American Journal of Physiology - Lung Cellular and Molecular Physiology 265 3 9-3 (1993): http://www.scopus.com/inward/record.url?eid=2-s2.0-0027453375&partnerID=MN8TOARS. Publicado Cancela, M.L.; Williamson, M.K.; Price, P.A.. "Retinoic acid increases matrix gla protein in rat plasma". Nutrition Research 13 1 (1993): 87-91. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027535868&partnerID=MN8TOARS. Publicado • 10.1016/S0271-5317(05)80659-1 Cancela, M.L.; Price, P.A.. "Retinoic acid induces matrix gla protein gene expression in human cells". Endocrinology 130 1 (1992): 102-108. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026553049&partnerID=MN8TOARS. Publicado Cancela, L.; Ishida, H.; Bishop, J.E.; Norman, A.W.. "Local chromatin changes accompany the expression of the calbindin-D28K gene: Tissue specificity and effect of vitamin D activation". Molecular Endocrinology 6 3 (1992): 468-475. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026525323&partnerID=MN8TOARS. Publicado Cancela, L.; Hsieh, C.-L.; Francke, U.; Price, P.A.. "Molecular structure, chromosome assignment, and promoter organization of the human matrix Gla protein gene". Journal of Biological Chemistry 265 25 (1990): 15040-15048. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025029949&partnerID=MN8TOARS. Acesso aberto • Publicado PARISI, M; CANCELA, L; Parisi, M.; Cancela, L.. "TIME COURSE STUDIES ON PHOSPHATE TRANSFER IN FROG URINARY-BLADDER". Kidney International 33 1 (1988): 58-63. http://www.scopus.com/inward/record.url?eid=2-s2.0-0023830190&partnerID=MN8TOARS. Publicado • 10.1038/ki.1988.9 Cancela, L.; Nemere, I.; Norman, A.W.. "1a,25 (OH)2 vitamin D3: A steroid hormone capable of producing pleiotropic receptor-mediated biological responses by both genomic and nongenomic mechanisms". Journal of Steroid Biochemistry 30 1-6 (1988): 33-39. http://www.scopus.com/inward/record.url?eid=2-s2.0-0023777632&partnerID=MN8TOARS. Publicado • 10.1016/0022-4731(88)90073-8 De Vernejoul, M.C.; Benamout, M.P.; Cancela, L.; Miravet, L.; Kuntz, D.; Gueris, J.; Gardin, J.P.. "Primary hyperparathyroidism seen in rheumatology. Clinical manifestations and relationship between bone history and biological parameters". Revue du Rhumatisme et des Maladies Osteo-Articulaires 55 7 (1988): 489-494. http://www.scopus.com/inward/record.url?eid=2-s2.0-0024005167&partnerID=MN8TOARS. Publicado Minghetti, P.P.; Cancela, L.; Fujisawa, Y.; Theofan, G.; Norman, A.W.. "Molecular structure of the chicken vitamin D-induced calbindin-D(28K) gene reveals eleven exons, six Ca2+-binding domains, and numerous promoter regulatory elements". Molecular Endocrinology 2 4 (1988): 355-367. http://www.scopus.com/inward/record.url?eid=2-s2.0-0023879973&partnerID=MN8TOARS. Acesso aberto Rebut-Bonneton, C.; Ly, S.Y.; Cancela, L.. "Calcium-transport in quiescent and 1,25-dihydroxycholecalciferol-stimulated human osteosarcoma cells. Role in 24 hydroxylase enhancement". Hormone and Metabolic Research 20 6 (1988): 339-343. http://www.scopus.com/inward/record.url?eid=2-s2.0-0023941120&partnerID=MN8TOARS. Publicado Cancela, L.; Rebut-Bonneton, C.. "Regulation of 24-hydroxylase activity in mouse skin fibroblasts by cholecalciferol derivatives, triamcinolone acetonide and a calcium modulating agent, nicardipine". Journal of Steroid Biochemistry 28 5 (1987): 479-484. http://www.scopus.com/inward/record.url?eid=2-s2.0-0023604856&partnerID=MN8TOARS. Publicado • 10.1016/0022-4731(87)90505-X Cancela, L.; Marie, P.J.; Le Boulch, N.; Miravet, L.. "Lack of biological activity of vitamin D3-3ß sulfate during lactation in vitamin D-deficient rats". Reproduction Nutrition Developpement 27 6 (1987): 979-997. http://www.scopus.com/inward/record.url?eid=2-s2.0-0023502969&partnerID=MN8TOARS. Publicado Le Boulch, N.; Cancela, L.; Miravet, L.; Lange, C.. "Assessment of vitamin D sulphate in human milk using desorption chemical ionization mass spectrometry". Biomedical Mass Spectrometry 13 2 (1986): 53-56. http://www.scopus.com/inward/record.url?eid=2-s2.0-0022572865&partnerID=MN8TOARS. Publicado Gruson, M.; Cancela, L.; Denne, M.A.; Miravet, L.. "Relationship between bone GLA-protein (BGP) and calcidiol (25-hydroxycalciferol) in serum of breast-fed infants.". Endocrinologia experimentalis 20 2-3 (1986): 329-334. http://www.scopus.com/inward/record.url?eid=2-s2.0-0022759472&partnerID=MN8TOARS. Publicado Cancela, L.; Le Boulch, N.; Miravet, L.. "Relationship between the vitamin D content of maternal milk and the vitamin D status of nursing women and breast-fed infants". Journal of Endocrinology 110 1 (1986): 43-50. http://www.scopus.com/inward/record.url?eid=2-s2.0-0022445355&partnerID=MN8TOARS. Publicado Marie, P.J.; Cancela, L.; Le Boulch, N.; Miravet, L.. "Bone changes due to pregnancy and lactation: Influence of vitamin D status". American Journal of Physiology - Endocrinology and Metabolism 251 4 (1986): http://www.scopus.com/inward/record.url?eid=2-s2.0-0022966994&partnerID=MN8TOARS. Publicado Le Boulch, N.; Cancela, L.; Miravet, L.. "Calcidiol in human milk. The effect of prohormone on vitamin D status of breast fed unsupplemented infants". Endocrinologia Experimentalis 20 2-3 (1986): 325-328. http://www.scopus.com/inward/record.url?eid=2-s2.0-0022981264&partnerID=MN8TOARS. Publicado Cancela, L.; Marie, P.J.; Le Boulch, N.; Miravet, L.. "Vitamin D3 3ß sulfate has less biological activity than free vitamin D3 during pregnancy in rats". Biology of the Neonate 48 5 (1985): 274-284. http://www.scopus.com/inward/record.url?eid=2-s2.0-0022271864&partnerID=MN8TOARS. Publicado Cancela, L.; Marie, P.J.; Le Boulch, N.; Miravet, L.. "Influence of vitamin D on mineral metabolism, hormonal status and bone histology in lactating rats and their pups". Journal of Endocrinology 105 3 (1985): 303-309. http://www.scopus.com/inward/record.url?eid=2-s2.0-0021848253&partnerID=MN8TOARS. Publicado Rebut-Bonneton, C.; Demignon, J.; Cancela, L.; Miravet, L.. "Effect of 25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 maternal loads on maternal and fetal vitamin D metabolite levels in the rat". Reproduction Nutrition Developpement 25 3 (1985): 583-590. http://www.scopus.com/inward/record.url?eid=2-s2.0-0021870967&partnerID=MN8TOARS. Publicado Cancela, L.; Le Boulch, N.; Miravet, L.. "Action of vitamin D3-3 beta-sulfate during lactation in the rat.". World review of nutrition and dietetics 43 (1984): 153-157. http://www.scopus.com/inward/record.url?eid=2-s2.0-0021143980&partnerID=MN8TOARS. Publicado de Vernejoul, M.C.; Girot, R.; Gueris, J.; Cancela, L.; Bang, S.; Bielakoff, J.; Mautalen, C.; Goldberg, D.; Miravet, L.. "Calcium phosphate metabolism and bone disease in patients with homozygous thalassemia". Journal of Clinical Endocrinology and Metabolism 54 2 (1982): 276-281. http://www.scopus.com/inward/record.url?eid=2-s2.0-0019960606&partnerID=MN8TOARS. Publicado Boulch, N.L.; Cancela, L.; Miravet, L.. "Cholecalciferol sulfate identification in human milk by HPLC". Steroids 39 4 (1982): 391-398. http://www.scopus.com/inward/record.url?eid=2-s2.0-0020470783&partnerID=MN8TOARS. Publicado • 10.1016/0039-128X(82)90063-0
Capítulo de livro	ML Cancela; Laizé, V; Rosa, Joana; Laizé, Vincent; Rosa, Joana T.; Tarasco, Marco; Cancela, M. Leonor. "Status, challenges, and perspectives of fish cell culture—Focus on cell lines capable of in vitro mineralization". In Cellular and molecular approaches in fish biology, editado por Fernández, Ignacio; Fernandes, JMO; Ignacio, Fernandez, 381-404. Elsevier, 2021. No prelo • 10.1016/b978-0-12-822273-7.00004-5 Kumar, Navdeep; Carletti, Alessio; Gavaia, Paulo J.; Muller, Marc; Cancela, M. Leonor; Geurts, Pierre; Marée, Raphaël; et al. "Deep Learning Approaches for Head and Operculum Segmentation in Zebrafish Microscopy Images". In Computer Analysis of Images and Patterns, 154-164. Liege, Bélgica: Springer International Publishing, 2021. Publicado • 10.1007/978-3-030-89128-2_15 Tiago, Daniel M.; Laizé, Vincent; Aureliano, M.; Cancela, Leonor. "Vanadate effects on bone metabolism: fish cell lines as an alternative to mammalian in vitro systems". In Vanadium Biochemistry, 1-12. Kerala, Índia: Research Signpost, 2007. Publicado
Livro	Antunes, Célia M.; Costa, Ana R.; Palma, Patrícia; Gastalho, Carlos; Marques, Mariana; Galveias, Ana; Cancela, Leonor; Aureliano, Manuel. XXI SPB CONGRESS BOOK. Universidade de Évora. 2022. Cancela, L.; Theofan, G.; Norman, A.W.. Chapter 15 The pleiotropic vitamin D hormone. New York, Estados Unidos: Elsevier Science Publishers B.V. 1988. Publicado • 10.1016/S0167-7306(08)60650-X
Poster em conferência	Gavaia, Paulo J.; Dionísio, G.; Conceição, L. E. C.; Hamre, K.; Cancela, Leonor. "Effects of phylloquinone on Solea senegalensis skeletogenesis". Trabalho apresentado em World Aquaculture 2011- Aquaculture for a changing world. June 6-10 2011, Natal convention center, Natal, Brazil., 2011. Dias, J.; Rodrigues, V.; Colen, Rita; Rosa, Joana; Viegas, M. N.; Cardeira, J.; Cancela, Leonor; Gavaia, Paulo J.; Laizé, Vincent. "Dietary lipid quality regulates bone composition and metabolism in gilthead seabream (Sparus aurata) juveniles". Trabalho apresentado em Interdisciplinary Approaches in Fish Skeletal Biology, April 26-28, Tavira, Portugal., 2011. Dionísio, G.; Cancela, Leonor; Gavaia, Paulo J.. "Effect of dietary vitamin K supplementation on skeletal development of Danio rerio". Trabalho apresentado em Interdisciplinary Approaches in Fish Skeletal Biology, April 26-28, Tavira, Portugal., 2011. Dionísio, G.; Bensimon-Brito, A.; Gavaia, Paulo J.; Cancela, Leonor. "Effect of warfarin in zebrafish (Danio rerio) bone formation during caudal fin regeneration". Trabalho apresentado em Interdisciplinary Approaches in Fish Skeletal Biology, April 26-28, Tavira, Portugal., 2011. Gavaia, Paulo J.; Nicolau, L.; Cancela, Leonor; Pousão-Ferreira, P.. "Early osteological development and deformities of Diplodus sargus (Linnaeus, 1758) and Diplodus vulgaris (Saint-Hillaire, 1817)". Trabalho apresentado em Interdisciplinary Approaches in Fish Skeletal Biology, April 26-28, Tavira, Portugal., 2011. Valles, E.; Cardeira, J.; Dionísio, G.; Estévez, A.; Pousão-Ferreira, P.; Cancela, Leonor; Gavaia, Paulo J.. "Early axial and appendicular skeletal development of the meagre (Argyrosomus regius). A comparison of two rearing systems". Trabalho apresentado em Interdisciplinary Approaches in Fish Skeletal Biology, April 26-28, Tavira, Portugal., 2011. Gavaia, Paulo J.; Dionísio, G.; Campos, C.; Carvalho, A. P.; Conceição, L. E. C.; Cancela, Leonor. "Temperature affects skeletogenesis during Senegalese sole (Solea senegalensis, Kaup) larval development". Trabalho apresentado em Interdisciplinary Approaches in Fish Skeletal Biology, April 26-28, Tavira, Portugal., 2011. Gavaia, Paulo J.; Dionísio, G.; Cardeira, J.; Cunha, M. E.; Pousão-Ferreira, P.; Conceição, L. E. C.; Cancela, Leonor. "Skeletal quality in Senegalese sole: characterization of fish resulting from environmental and nutritional trials". Trabalho apresentado em Workshop Cultivation of soles, 2011.
Pré-impressão	João Cardeira-da-Silva; Anabela Bensimon-Brito; Marco Tarasco; Ana S. Brandão; Joana Rosa; Paulo J. Almeida; António Jacinto; et al. "Fin ray branching is defined by TRAP+ osteolytic tubules". 2022. https://doi.org/10.1101/2022.05.09.491182. 10.1101/2022.05.09.491182
Recurso online	ML Cancela. Inovação e Partilha Pedagógica na UAlg. 2020.
Tese / Dissertação	"EPIGENETIC REGULATION OF ZNF687 IN BONE CELLS: ELUCIDATION OF ITS ROLE IN THE PROGRESSION OF PAGET’S DISEASE TOWARDS GIANT CELL TUMOR OF BONE". Doutoramento, Faculdade de Medicina e Ciências Biomédicas, Universidade do Algarve, 2024. "IDENTIFICATION OF NOVEL CDKL5 MOLECULAR TARGETS/PATHWAYS ASSOCIATED WITH SKELETAL DEFECTS PRESENT IN CDKL5 ASSOCIATED DISORDERS". Doutoramento, Faculdade de Medicina e Ciências Biomédicas, Universidade do Algarve, 2024. Poudel, Sunil. "Effect of Antioxidant and Pro-oxidant on Bone mineralization and Remodelling". Doutoramento, Faculdade de Medicina e Ciências Biomédicas, Universidade do Algarve, 2023. http://hdl.handle.net/10400.1/19664. Carletti, Alessio. "Effect of marine-derived extracts on mineralogenesis". Doutoramento, Faculdade de Medicina e Ciências Biomédicas, Universidade do Algarve, 2023. http://hdl.handle.net/10400.1/20069. "Função da Elastina no desenvolvimento das calcificações ectópicas da cartilagem associadas a uma deficiência em MGP: contribuição para o estudo da sindrome de Keutel". Mestrado, Universidade de Coimbra, 2022. Alfaia, Ana Sofia de Almeida. "ANALYSIS OF THE MUTATIONS ASSOCIATED WITH PAGET DISEASE OF BONE IN A SET OF PATIENTS FROM ALENTEJO AND ALGARVE". Mestrado, Universidade do Algarve - Campus de Gambelas, 2022. http://hdl.handle.net/10400.1/18645. Caiado, Helena Isabel Rosa Pinto. "Molecular basis for the epigenetic regulation of MGP in cancer". Doutoramento, Faculdade de Medicina e Ciências Biomédicas, Universidade do Algarve, 2022. http://hdl.handle.net/10400.1/19633. Tarasco, Marco. "How microplastics and adsorbed pollutants affect zebrafish development?". Doutoramento, Universidade do Algarve - Campus de Gambelas, 2022. http://hdl.handle.net/10400.1/18456. Silva, Joel Mourato da. "Characterization of 5´ and 3´ UTRs from Bone morphogenetic protein receptor type 1A (Bmpr1A) transcripts under the context of bone metabolism". Mestrado, Universidade do Algarve Faculdade de Ciências e Tecnologia, 2021. http://hdl.handle.net/10400.1/18181. Borges, Inês Sá da Costa Pereira. "Caracterização de duas linhas de peixe-zebra mutantes para a elastina no estudo da síndrome de Keutel". Mestrado, Faculdade de Medicina e Ciências Biomédicas, Universidade do Algarve, 2021. http://hdl.handle.net/10400.1/18174. "Molecular and Functional Analysis of Mutations in the Transcription Factor ZNF687 Associated to Paget Disease of Bone". Mestrado, Universidade do Algarve - Campus de Gambelas, 2019. http://hdl.handle.net/10400.1/13585. Franco, Hannah Sabrina. "CRISPR: applications in human pathologies and future prospects". Mestrado, Universidade do Algarve Faculdade de Ciências e Tecnologia, 2018. http://hdl.handle.net/10400.1/12618. Varela, Débora Cristina Domingos. "Genetic and functional analysis of specific TBX5 mutations associated with Holt-Oram Syndrome". Mestrado, Universidade do Algarve, 2017. http://hdl.handle.net/10400.1/10470. Simão, Márcio Alexandre Filipe. "Contribution to the molecular characterization of osteoarthritis and osteoporosis phenotypes associated with hereditary hemochromatosis". Doutoramento, Faculdade de Medicina e Ciências Biomédicas, Universidade do Algarve, 2017. http://hdl.handle.net/10400.1/10812. Silva, Inês Martins. "Contribuição para a identificação do papel da MGP no desenvolvimento tumoral no cancro colorretal". Mestrado, Universidade do Algarve, 2016. http://hdl.handle.net/10400.1/9899. Cancela, Maria Leonor; Branco, Jaime da Cunha; Camacho, António Manuel Mendonça Romão de Brito. "Characterization of the clinical, histological and genetic profile of articular damage in hereditary hemochromatosis". Doutoramento, Universidade Nova de Lisboa Faculdade de Ciências Médicas, 2016. http://hdl.handle.net/10362/19226. Carvalho, Filipe Ricardo Pires de. "Characterization of bone pathologies in the ins2+/akita mouse, a new model for diabetes insulindependent: contribution for a better understanding of the disease in humans". Doutoramento, Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, 2016. http://hdl.handle.net/10400.1/8680. Tarasco, Marco. "Screening natural resources for mineralogenic and osteogenic bioactivities using in vitro and in vivo fish systems". Mestrado, Universidade do Algarve - Campus de Gambelas, 2016. http://hdl.handle.net/10400.1/8653. Hill, Billy Samuel. "Drug repurposing in the treatment of Melanoma Brain Metastasis". Mestrado, Universidade do Algarve, 2015. http://hdl.handle.net/10400.1/8219. Silva, Iris Alexandra Lopes da. "Genetic and functional analysis of the PDB6 locus in Paget's disease of bone". Doutoramento, Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, 2015. http://hdl.handle.net/10400.1/7669. Rosa, Joana Alexandra Teixeira. "Identification of novel molecular determinants of tissue mineralization in fish". Doutoramento, Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, 2015. http://hdl.handle.net/10400.1/8756. Adrião, Andreia Lúcia Gonçalves. "MEF2C: expression, regulation and interaction with target genes in health and diseases". Doutoramento, Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, 2015. http://hdl.handle.net/10400.1/8751. Anastácio, Fábio Miguel Vicente. "Estudo do papel desempenhado pela proteína anexina A2 na regulação de vias de transdução de sinal ativadas por Ras". Mestrado, Faculdade de Medicina e Ciências Biomédicas, Universidade do Algarve, 2015. http://hdl.handle.net/10400.1/7870. Rodrigues, Brigite Sandra Nunes Simões. "Molecular structure and functional analysis of runx3 in zebrafish". Doutoramento, Faculdade de Medicina e Ciências Biomédicas, Universidade do Algarve, 2014. http://hdl.handle.net/10400.1/6851. Roberto, V.. "Identification and molecular characterization of bone-related micrornas: functional implications". Doutoramento, Faculdade de Medicina e Ciências Biomédicas, Universidade do Algarve, 2014. http://hdl.handle.net/10400.1/7080. Fazenda, Cindy Vitória. "Molecular characterization of Gla-rich protein (GRP) gene expression and function". Doutoramento, Faculdade de Medicina e Ciências Biomédicas, Universidade do Algarve, 2014. http://hdl.handle.net/10400.1/6842. Marques, Cátia Andreia Lourenço. "Evolution, gene regulation and functional analysis of BMP2 in fish". Doutoramento, Universidade do Algarve, 2013. http://hdl.handle.net/10400.1/6751. Fonseca, Maria Leonor Quintais Cancela da; Fonseca, Luís Daniel Salsinha. "Spatio-temporal gene expression and evolutionary relationship of seabream betainehomocysteine S-methyltransferases". Mestrado, Universidade de Lisboa, 2012. http://hdl.handle.net/10400.1/10516. Brito, Anabela Ben-Simon. "Insights into molecular and cellular events involved in normal and pathological vertebral development and fusion using zebrafish as model organism". Doutoramento, Universidade do Algarve, 2012. http://hdl.handle.net/10400.1/5754. Lisboa, Rodrigo. "Cytogenetic and histological studies of the brook trout (Salvelinus fontinalis) x arctic charr (Salvelinus alpinus) hybrids". Mestrado, Universidade do Algarve Faculdade de Ciências e Tecnologia, 2012. http://hdl.handle.net/10400.1/5733. Carvalho, Inês Costa de. "Population structure of humpback whales (Megaptera novaeangliae) in west coast of Africa". Mestrado, 2012. http://hdl.handle.net/10400.1/12188. Cancela, Maria Leonor; Leite, Ricardo B.. "Exploring an uncommon host-parasite interaction to unveil the uniqueness of Perkinsus sp as a model organism". Doutoramento, Universidade do Algarve Faculdade de Ciências e Tecnologia, 2011. http://hdl.handle.net/10400.1/5704. Simão, Márcio Alexandre Filipe. "Identificação e caracterização de duas isoformas da Ferritina da amêijoa R. decussatus e avaliação de algumas das suas propriedades biológicas". Mestrado, Universidade do Algarve Faculdade de Ciências e Tecnologia, 2011. http://hdl.handle.net/10400.1/2655. Silva, Iris Alexandra Lopes da. "Molecular cloning and analysis of Xeroderma pigmentosum group-D (xpd) in zebrafish". Mestrado, Universidade do Algarve, 2011. http://hdl.handle.net/10400.1/2233. Rafael, M. S.. "Role of the transcriptional regulator FHL2: identification of fish target genes and regulatory mechanisms". Doutoramento, Universidade do Algarve Faculdade de Ciências e Tecnologia, 2011. http://hdl.handle.net/10400.1/3734. Santos, Rui Pedro Peres dos. "O efeito da Varfarina no desenvolvimento esquelético de larvas de peixe zebra (Danio rerio)". Mestrado, 2009. http://hdl.handle.net/10400.1/11039. Silva, João Pedro Gonçalves Cardeira da. "O efeito da dieta na sobrevivência e no desenvolvimento esquelético e digestivo de larvas e juvenis de peixe-zebra Danio rerio (Hamilton, 1822)". Mestrado, Universidade do Algarve, 2009. http://hdl.handle.net/10400.1/672. Fonseca, Maria Leonor Quintais Cancela da; Vasta, Gerardo; Ascenso, Rita Margarida Teixeira. "Study of Perkinsus olseni infection mechanisms: identification and regulation of parasite genes differentially expressed in response to host and environmental stress". Doutoramento, Universidade do Algarve Faculdade de Ciências e Tecnologia, 2008. http://hdl.handle.net/10400.1/301. Fonseca, Maria Leonor Quintais Cancela da; Gama, Francisco Miguel Portela da; Afonso, Ricardo. "Estudos sobre aproveitamento biotecnológico da quitina produzida por organismos marinhos". Mestrado, Universidade do Algarve Faculdade de Ciências e Tecnologia, 2008. http://hdl.handle.net/10400.1/710. Rainha, Rita Vanessa Cardoso de Almeida. "Estudo da variabilidade genética de marcadores moleculares ligados ao gene da MGP e sua aplicação para paternidades em Sparus aurata". Mestrado, 2008. http://hdl.handle.net/10400.1/530. Madeira, Céline Rodrigues. "Contribuição parental do linguado do Senegal, Solea senegalensis (KAUP 1858), em aquacultura". Mestrado, Universidade do Algarve Faculdade de Ciências e Tecnologia, 2008. http://hdl.handle.net/10400.1/245. Tiago, Daniel M.. "Role of insulin and insulin-like peptides in bone formation: identification of bone-specific target genes and regulatory mechanisms, and characterization of the insulin-mimetic effect of vanadium". Doutoramento, Universidade do Algarve Faculdade de Ciências e Tecnologia, 2008. http://hdl.handle.net/10400.1/422. Abreu, Maria Manuela Silva Nunes Reis; Santos, Maria Cristina Amaral Penas Nabais dos; Fonseca, Maria Leonor Quintais Cancela da; Santos, Erika Silva. "Potencial de utilização de Cistus ladanifer L. na vegetalização de áreas mineiras". Mestrado, Universidade do Algarve Faculdade de Ciências e Tecnologia, 2007. http://hdl.handle.net/10400.1/1798. Cancela, Maria Leonor; Dias, Pedro Beja; Dias, Paula; Mira, Sara. "Population genetics of an endangered species: the Bonelli's eagle (Hieraaetus fasciatus)". Doutoramento, Universidade do Algarve Faculdade de Ciências e Tecnologia, 2006. http://hdl.handle.net/10400.1/10627. Cancela, Maria Leonor; Gavaia, Paulo; Roberto, Vânia Cristina Palma. "Gla protein localization and histological characterization of bone stuctures in relevant aquaculture fish". Mestrado, Universidade do Algarve Faculdade de Ciências e Tecnologia, 2006. http://hdl.handle.net/10400.1/11026. Silva, Maria da Conceição Monteiro Patrício. "Desenvolvimento de ferramentas interactivas para divulgação das aplicações da biotecnologia ambiental em biorremediação". Mestrado, 2006. http://hdl.handle.net/10400.1/14813. Gavaia, Paulo J.. "Functional analysis of bone related Gla proteins from bony fish during skeletal development". Doutoramento, 2005. http://hdl.handle.net/10400.1/7614. Fonseca, Vera Alexandra Garcia. "Up-regulated genes during in vitro mineralization of Sparus aurata osteoblast-like cells". Mestrado, 2005. http://hdl.handle.net/10400.1/11058. Inácio, Ana Rita da Silva. "Selecção de áreas prioritárias para a conservação da biodiversidade no sul de Portugal". Mestrado, 2004. http://hdl.handle.net/10400.1/1641. Pombinho, António José Ribeiro. "Reguladores da expressão do gene da proteía Gla da matriz (MGP) numa linha celular derivada de peixe". Mestrado, 2004. http://hdl.handle.net/10400.1/8554. Pais, Susana Isabel da Silva. "A legislação portuguesa de segurança biológica, um instrumento de gestão ambiental?". Mestrado, 2003. http://hdl.handle.net/10400.1/8520. Guerreiro, Miguel. "Monitorização da actividade bioelectroquímica da bomba de cálcio do retículo sarcoplasmático". Licenciatura, 2003. http://hdl.handle.net/10400.1/4828. Simes, Dina Cristina F. R. Costa. "Purification, biochemical characterization and localization at single cell resolution of Matrix Gla Protein (MGP) and Bone Gla Protein (BGP) in the teleost fish Argyrosomus regius". Doutoramento, 2002. http://hdl.handle.net/10400.1/8458. Pinto, Idílio Jorge Matias Pereira. "Cloning of the Bone Gla Protein gene from the teleost fish Sparus aurata (gilthead seabream). Molecular organization, developmental appearance and evolutionary implications". Doutoramento, Universidade do Algarve, 2001. http://hdl.handle.net/10400.1/7187. Henriques, Nuno Miguel Carvalho de Sousa de Paula. "Clonagem do gene de matrix gla protein (MGP) da espécie xenopus leavis (Daudin, 1802)". Mestrado, Universidade do Algarve, 1997. http://hdl.handle.net/10400.1/10979. Navalho, João. "Biotecnologia de Dunaliella salina para produção de B caroteno". Mestrado, Universidade do Algarve, 1997. http://hdl.handle.net/10400.1/8469.

Propriedade Intelectual

Marca registada

2009. "Lab-it Laboratorio Itinerante em Genética Molecular".
Registada
2009. "Lab-it".
Registada

Patente

Danielsen, Steffen ; Lars Kobberoee Skov; Leite, Ricardo B; Laizé, V; Leonor Cancela. 2016. "Dfpase enzymes from aplysia californica".
Concedida/Emitida
M Leonor Cancela; Laizé, V.; Danielsen, Steffen ; Skov LK; Leite, Ricardo B. 2016. "DFPase enzymes from Aplysia Californica". Dinamarca.
Concedida/Emitida
Leonor Cancela; Conceição, Natércia; Tiago, Daniel. 2015. "Utilização da MGP como método de diagnóstico, prognostico e alvo terapêutico no cancro".
Expirada
Schnorr, KM; Leonor Cancela; Leite, Ricardo B; Anderson L. 2013. "Polypeptides having cellulose activity and polynucleotides encoding same".
Concedida/Emitida
Leonor Cancela; Leite, Ricardo B; Schnorr, KM; Anderson L. 2012. "Polypeptides having cellulose activity and polynucleotides encoding same". Dinamarca.
Concedida/Emitida
Leonor Cancela; Simes, Dina; S B Viegas, Carla. 2010. "A gammacarboxyglutamate-rich protein, methods and assays for its detection, purification and quantification and uses thereof".
Expirada
ML Cancela; Bensimon-Brito, Anabela; Gavaia, P; Laizé, V. 2010. "Integrated screening methods for identifying modulators of mineralization, and modulators identified therefrom".
Concedida/Emitida
Leonor Cancela; Laizé, V; Leite, Ricardo B; Danielsen S; Skov LK. 2010. "New isolated polypeptide having organophosphorous hydrolase activity selected from polypeptide containing amino acid sequence, polypeptide encoded by polynucleotide, variant containing deletion of amino acids, used in nucleic acid construct". Estados Unidos.
Concedida/Emitida
Leonor Cancela; Danielsen, Steffen ; Skov LK; Leite, Ricardo B; Laizé, V.. 2010. "New isolated polypeptide having organophosphorous hydrolase activity selected from polypeptide containing amino acid sequence, polypeptide encoded by polynucleotide, variant containing deletion of amino acids, used in nucleic acid construct". Dinamarca.
Concedida/Emitida
Leonor Cancela; Laizé, V; Leite, Ricardo B; Danielsen, Steffen ; Skov LK. 2010. "New isolated polypeptide with organophosphorus hydrolase activity selected from e.g. polypeptide with amino acid sequence having specific identity to mature polypeptide and polypeptide encoded by polynucleotide, used in such as composition". Dinamarca.
Concedida/Emitida
M Leonor Cancela; Gavaia, P; Bensimon-Brito, Anabela; Laizé, V. 2010. "Identification of compound that affects osteogenesis, involves inducing fin regeneration of ray-finned fish by amputating fish fin, contacting fish with test compound, and determining re-mineralization index of fin regeneration". Estados Unidos.
Concedida/Emitida
Leonor Cancela; Simes, Dina; Viegas, Carla. 2010. "A gammacarboxyglutamate-rich protein, methods and assays for its detection, purification and quantification and uses thereof".
Concedida/Emitida
M Leonor Cancela; Gavaia, P; Laizé, V; Anabela Bensimon-Brito. 2009. "Identification of compound that affects osteogenesis, involves inducing fin regeneration of ray-finned fish by amputating fish fin, contacting fish with test compound, and determining re-mineralization index of fin regeneration".
Expirada

Outros

Outra produção

Skeletal development and bone-related gene expression in fish larvae. The fish skeleton; skeletal malformations; skeletal malformations in mediterranean species; Types of skeletal malformations; Senegal sole skeletal development; Senegal sole skeletal deformities; Skeletal development in Danio rerio; ALP and TRAP in skeletal development; Skeletal development in Pagrus auriga; Time course of skeletal development in Pagrus auriga; Spatio-temporal pattern of bgp expres. 2006. Gavaia, Paulo J.; Cancela, Leonor. http://hdl.handle.net/10400.1/4397.

Atividades

Apresentação oral de trabalho

	Título da apresentação	Nome do evento Anfitrião (Local do evento)
2021/09/21	Holt Oram syndrome and Thalidomide toxicity: same molecular targets??	Webinar series_COST action Eurosoftcalcnet Tamas Aranyi (online, Hungria)

Orientação

	Título / Tema Papel desempenhado	Curso (Tipo) Instituição / Organização
2020/03/01 - Atual	IDENTIFICATION OF NOVEL CDKL5 MOLECULAR TARGETS/PATHWAYS ASSOCIATED WITH SKELETAL DEFECTS PRESENT IN CDKL5 ASSOCIATED DISORDERS Coorientador	Biomedical Sciences (Doutoramento) Faculdade de Medicina e Ciências Biomédicas, Universidade do Algarve, Portugal
2019/03/01 - Atual	Epigenetic regulation of ZNF687 in bone cells: elucidation of its role in the progression of Paget’s disease towards giant cell tumor of bone Coorientador	Biomedical Sciences (Doutoramento) Faculdade de Medicina e Ciências Biomédicas, Universidade do Algarve, Portugal
2019/01 - Atual	Effect of marine derived extract on osteogenesis and mineralogenesis Coorientador	Biomedical Sciences (Doutoramento) Faculdade de Medicina e Ciências Biomédicas, Universidade do Algarve, Portugal
2019/01 - Atual	Effects of anti- and pro-oxidants in bone mineralization and remodelling Coorientador	Biomedical Sciences (Doutoramento) Faculdade de Medicina e Ciências Biomédicas, Universidade do Algarve, Portugal
2017/10 - Atual	How microplastics and adsorbed pollutants affect zebrafish development? Coorientador	PhD Program in Marine, Earth and Environmental Sciences, (Doutoramento) Universidade do Algarve - Campus de Gambelas, Portugal
2017 - Atual	Molecular basis for the epigenetic regulation of MGP in cancer Coorientador	Ciencias Biomédicas (Doutoramento) Faculdade de Medicina e Ciências Biomédicas, Universidade do Algarve, Portugal
2012 - 2017	"CONTRIBUTION TO THE MOLECULAR CHARACTERIZATION OF OSTEOARTHRITIS AND OSTEOPOROSIS PHENOTYPES ASSOCIATED WITH HEREDITARY HEMOCHROMATOSIS" Orientador	Ciências Biomédicas (Doutoramento) Universidade do Algarve, Portugal
2013 - 2016/10	Characterization of the histological and genetic profile of articular damage in a hemochromatosis mouse model". Orientador	Medicina (Doutoramento) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2011 - 2016	Characterization of bone pathologies in the ins2+/akita mouse, a new model for diabetes insulindependent: contribution for a better understanding of the disease in humans Orientador	Ciências Biomédicas (Doutoramento) Universidade do Algarve, Portugal
2012 - 2015	Genetic and functional analysis of the PDB6 locus in Paget´s disease of bone Orientador	Ciências Biomédicas (Doutoramento) Universidade do Algarve, Portugal
2010 - 2015	Mef2c: Expression, Regulation and Interaction with Target Genes in Health and Diseases Orientador	Ciências Biomédicas (Doutoramento) Universidade do Algarve, Portugal
2010 - 2015	Molecular Characterization of Gla Rich Protein (GRP) Gene Expression and Function Orientador	Ciências Biomédicas (Doutoramento) Universidade do Algarve, Portugal
2009 - 2015	IDENTIFICATION OF NOVEL MOLECULAR DETERMINANTS OF TISSUE MINERALIZATION IN FISH Orientador	Ciências Biomédicas (Doutoramento) Universidade do Algarve, Portugal
2008 - 2015	EVOLUTION, GENE REGULATION AND FUNCTIONAL ANALYSISN OF BMP2 IN FISH Orientador	Ciências Biomédicas (Doutoramento) Universidade do Algarve, Portugal
2007 - 2014	MOLECULAR STRUCTURE AND FUNCTIONAL ANALYSIS OF RUNX3 IN ZEBRAFISH Orientador	Ciências Biomédicas (Doutoramento) Universidade do Algarve, Portugal
2009 - 2012/12	Insights into molecular and cellular events involved in human pathological fusion of vertebral joints through the use of zebrafish as model organism Coorientador	Molecular and Cellular Biology (Doutoramento) Universidade do Algarve - Campus de Gambelas, Portugal
2008 - 2012/05	Characterization of metabolic pathways in the protozoan parasite Perkinsus atlanticus/olseni: Identification of potential targets for therapeutic drugs Orientador	Bioquimica (Doutoramento) Universidade do Algarve - Campus de Gambelas, Portugal
2004/09/01 - 2012/02	Abundance, site fidelity and population structure of humpbacks whales (Megaptera novaeangliae) in S. Tomé e Príncipe” Coorientador	Population Genetics (Doutoramento) Universidade do Algarve - Campus de Gambelas, Portugal
2008 - 2012	Study of Perkinsus Olseni Infection Mechanisms: Identification and Regulation of Parasite Genes Differentially Expressed in Response to Host and Environmental Stress Orientador	Biologia (Doutoramento) Universidade do Algarve, Portugal
2005/04/01 - 2011/05	Role of the transcriptional regulator FHL2 in bone formation: Identification of fish bone-specific target genes and regulatory mechanisms" Coorientador	Bioquimica (Doutoramento) Universidade do Algarve - Campus de Gambelas, Portugal
2005/04 - 2010/07	Identification and characterization of a new calcium binding protein from sturgeon, Gla rich protein or GRP. Contribution to unveil its function in vertebrates Coorientador	BIoquimica (Doutoramento) Universidade do Algarve - Campus de Gambelas, Portugal
2003/09/01 - 2008	Effects of vanadate and insulin treatment on proliferation, differentiation and mineralization of two fish bone derived cell lines, Vsa13 e Vsa116 Coorientador	Bioquimica (Doutoramento) Universidade do Algarve - Campus de Gambelas, Portugal
2003 - 2008	Identification of P. Atlanticus genes differentially expressed in response to parasite-host interaction and development of an in vivo infestation system Coorientador	Biologia Molecular (Doutoramento) Universidade do Algarve - Campus de Gambelas, Portugal
1999 - 2006/11	Population genetics of an endangered species, the Bonelli’s eagle(Hieraaetus fasciatus) Coorientador	Population genetics (Doutoramento) Universidade do Algarve - Campus de Gambelas, Portugal
2000 - 2005/07	“Functional analysis of bone-related Gla proteins from bony fish during skeletal development”. Orientador	Biologia Molecular (Doutoramento) Universidade do Algarve - Campus de Gambelas, Portugal
1998 - 2003/01	Matrix Gla protein (MGP) de peixe: abordagem bioquímica e estrutural para o esclarecimento da sua função biológica Orientador	Bioqumica (Doutoramento) Universidade do Algarve - Campus de Gambelas, Portugal
1998 - 2002/12	Controle da expressão genética da proteina da matriz extracelular “matrix Gla protein”: estudos comparativos em anfíbios e peixes Orientador	Molecular biology Universidade do Algarve - Campus de Gambelas, Portugal
1995 - 2001	Clonagem do gene da proteína BGP (Bone Gla protein) do peixe ósseo Sparus aurata (dourada). Organização molecular, expressão ao longo do desenvolvimento e implicações evolutivas”. Orientador	Molecular biology (Doutoramento) Universidade do Algarve - Campus de Gambelas, Portugal

Organização de evento

	Nome do evento Tipo de evento (Tipo de participação)	Instituição / Organização
2021/04 - 2021/10/31	Organização do Encontro anual de doutorandos da Universidade do Algarve https://www.ualg.pt/en/doctoral-college (2021/10/29 - 2021/10/29) Conferência (Presidente da Comissão Organizadora)	Universidade do Algarve, Portugal

Júri de grau académico

	Tema Tipo de participação	Nome do candidato (Tipo de grau) Instituição / Organização
2022/02	PhD: Stress granules in Polyglutamine diseases: new targets for therapeutic intervention? Presidente do júri	Adriana do Vale Marcelo (Doutoramento) Faculdade de Medicina e Ciências Biomédicas, Universidade do Algarve, Portugal
2022/01/24	PhD em Ciências Biomédicas, especialidade de Neurociências, Faculdade Medicina da Universidade de Lisboa, Arguente principal	Catarina Miranda Lourenço, (Doutoramento) Universidade de Lisboa Faculdade de Medicina, Portugal
2022/01/14	Provas de Agregação em ECOLOGIA HUMANA E ADAPTAÇÃO Arguente principal	Cristina Maria Proença Padez (Agregação) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2021/09	PhD: Development of a high throughput screening strategy for drug discovery: from marine fungi to stem cell application Arguente principal	Pietro Marchese (Doutoramento) National University of Ireland Galway School of Medicine, Irlanda
2021/07/30	Provas de Agregação em Biomedicina: Celulas estaminais e terapias celulares Arguente principal	Liliana Inácio Bernardino (Agregação) Universidade da Beira Interior Faculdade de Ciências da Saúde, Portugal
2021/05/28	Provas de Agregação em Biologia, especialidade de Biologia Celular e Saúde Arguente principal	Sandra Cristina Almeida Paiva (Agregação) Universidade do Minho Escola de Ciências, Portugal
2021/01/14	Provas de Agregação em Ciencias Biomédicas- Celulas Estaminais Vogal	José Eduardo Marques Bragança (Agregação) Faculdade de Medicina e Ciências Biomédicas, Universidade do Algarve, Portugal
2015	DRUG REPURPOSING IN THE TREATMENT OF MELANOMA BRAIN METASTASIS Vogal	BILLY SAMUEL HILL (Mestrado) Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal

Arbitragem científica em conferência

	Nome da conferência	Local da conferência
2021/06 - 2022/05	Meeting of the European Calcified Tissue Society. Helsinquia 2022	ECTS
2020/06 - 2021/06	European Calcified Tissue Society Congress	ECTS

Comissão de avaliação

	Descrição da atividade Tipo de assessoria	Instituição / Organização	Entidade financiadora
2019/01 - 2022/12	Convite para integrar painel de avaliação dos relatorios finais de projectos da FCT 2019-2022, area da Biologia Experimental e Bioquimica Avaliador	Fundação para a Ciência e a Tecnologia, Portugal	Fundação para a Ciência e a Tecnologia
2022/01 - 2022/07	A3ES: convite para avaliar novos cursos, área da biotecnologia Avaliador
2021/11/05 - 2022/02/28	Invitation to participate in evaluation of the proposal(s) submitted in response to the following call(s) for proposal(s): - HORIZON-MSCA-2021-PF-01 Avaliador	European Commission, Bélgica	European Commission
2021/12 - 2022/02/07	21-FWO-PDOC-0556 - Harnessing transcriptome and proteome wide analyses and engineered reporter assays to unravel the immunopathogenesis of 'multisystem inflammatory syndrome in children' (MIS-C). Avaliador	European Science Foundation, França	Research Foundation Flanders’ (FWO)
2021/12 - 2022/01/04	Evaluation of postdoctoral fellowships- PARIS REGION FELLOWSHIP PROGRAMME Avaliador	Paris Region FP, França	European Commission Marie Sklodowska-Curie Actions
2021/12 - 2022/01	Avaliação do relatório de atividades da Prof Associada do departamento de Biologia Animal da FCUL Avaliador	Universidade de Lisboa, Faculdade de Ciências, Portugal
2021/12 - 2022	A3ES_Convite para participar na avaliação de novos ciclos de estudo na area da Biologia / Biomedicina Avaliador		A3ES
2021/12/01 - 2021/12/31	European Calcified Tissue Society- evaluation of applications for ECTS Academy Avaliador	European Calcified Tissue Society, Reino Unido	European Calcified Tissue Society
2015/09 - 2021/12/13	Invitation to be part of the evaluation committee for annual applications for Medalhas l'Oreal Avaliador	Fundação para a Ciência e a Tecnologia, Portugal	Fundação L'Oreal
2021/07 - 2021/09	Participate in peer review of scientific proposals submitted to ERC starting grant 2021 call Avaliador	European Research Council, Bélgica	European Research Council
2021/02 - 2021/03	Invitation to integrate evaluation committee for FWO postdoctoral applications Avaliador	Research Foundation Flanders’ (FWO) , Bélgica	Research Foundation Flanders’ (FWO)

Membro de associação

	Nome da associação	Tipo de participação
2014 - Atual	European Calcified Tissue Society	member
1993/01/01 - Atual	Sociedade Portuguesa de Bioquimica-Member(ongoing). Presidente elect 2005-2008. President of the General Assembly2009-2010	Member
2020/01/31 - 2024/01/31	President of the Portuguese Society of Genetics, elected in January 2020 for 2 year period. Re-elected for a second 2yr term until January 2024	President
1986 - 2020	American Society for Bone and Mineral Research	member

Membro de comissão

	Descrição da atividade Tipo de participação	Instituição / Organização
2020/02 - 2025/01	Presidente da Socidade Portuguesa de Genética / President of the Portuguese Society of Genetics Presidente / Vice-presidente	Sociedade Portuguesa de Genética, Portugal
2021 - 2025	Presidente do Conselho Cientifico Presidente / Vice-presidente	Faculdade de Medicina e Ciências Biomédicas, Universidade do Algarve, Portugal
2019 - 2025	Director of the Doctoral College, University of Algarve, by appointment of the rector Diretor	Universidade do Algarve, Portugal
2006 - 2025	Director of the Bachelor degree (Licenciatura) in Biomedical Sciences Diretor	Faculdade de Medicina e Ciências Biomédicas, Universidade do Algarve, Portugal
2021/12 - 2022/05	procedimento concursal internacional para professor catedrático na Faculdade de Ciências e Tecnologia referência: P053-21-11331, area das ciencias da vida. Edital_1480_2021 Membro	Universidade de Coimbra, Portugal
2021/11/01 - 2022/02/28	Membro da Comissão de avaliação das candidaturas ao curso de medicina da Universidade do Algarve- Avaliação e creditação de formação anterior de + de 100 candidaturas Membro	Faculdade de Medicina e Ciências Biomédicas, Universidade do Algarve, Portugal
2021/02/12 - 2022/02/10	concurso documental internacional, para recrutamento na modalidade de contrato de trabalho em funções públicas por tempo indeterminado, para 1 posto de trabalho e provimento da respetiva vaga na categoria de professor catedrático na área disciplinar de Biomedicina, do mapa de pessoal docente da Universidade da Beira Interior, Edital n.º 192/2021 de 12 de Fev de 2021 Membro	Universidade da Beira Interior, Portugal
2021 - 2021/04/26	Concurso internacional para ocupação de um posto de trabalho da carreira docente universitária, na categoria de Professor Associado, área disciplinar de Ciências da Vida, especialidade de Biofísica, Bioeletrónica e Biosensores da Faculdade de Ciências e Tecnologia da Universidade de Coimbra, cujo edital Edital n.º 273/2021, publicado em Diário da República, 2.ª série, n.º 44, de 04/03. Membro	Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2004 - 2008	Presidente da Sociedade Portuguesa de Bioquimica / President of the Portuguese Society of Biochemistry Presidente / Vice-presidente	Sociedade Portuguesa de Bioquimica, Portugal

Distinções

Prémio

2022	Premio de boas praticas de excelencia da UALG_2021 Universidade do Algarve, Portugal
2019	2019 ECTS Basic Science Webinar Award European Calcified Tissue Society, Reino Unido
2016	Premio "Mulheres na Ciencia" 1ª edição 2016 Ciência Viva, Portugal

Outra distinção

2018	MSCA-ITN-2017 — Innovative Training Networks / 766347 — BioMedaqu EU Framework Programme for Research and Innovation Marie Sklodowska-Curie Actions, Bélgica
2017	RED CYTED LARVAplus IberoAmerican Network- member Organização dos Estados Ibero-americanos para a Educação a Ciência e a Cultura, Brasil
2017	COST action EUROSOFTCALNET/CA16115-A European Network for Connective Tissue Calcifying Diseases European Commission, Bélgica
2017	member of Scientific Programme Committee (SPC) of ECTS 2018 European Calcified Tissue Society, Reino Unido
2008	PROGRAMA NA FRONTEIRA DAS CIÊNCIAS DA VIDA - Prize awarded to Daniel M. Tiago (PI), Vincent Laizé, Manuel Santos and M. Leonor Cancela (50,000 euros) Fundação Calouste Gulbenkian, Portugal
2008	2008-2010_COST ACTION FA0801-LARVANET European Commission, Bélgica
2007	2007-2008_COST ACTION B23-Cranial-Facial regeneration European Commission, Bélgica
2007	2007-2008_Collaborative action_ PESSOA program_ DEEPBONE Fundação para a Ciência e a Tecnologia, Portugal
1989	Poster award. American Society for Bone and Mineral Research American Society for Bone and Mineral Research, Estados Unidos