MARIA DE FÁTIMA CARVALHO NOGUEIRA (7B1B-1ABB-1A16)

Curriculum Vitae

MARIA DE FÁTIMA CARVALHO NOGUEIRA

Fatima Nogueira FN is a Principal Investigator at Medical Parasitology UNIT, IHMT-NOVA. Graduated in Molecular Microbiology and Genetics from the University of Lisbon in 1996, she obtained a Master in Medical parasitology at IHMT-NOVA in 2001 and a PhD in Biomedical Sciences, specialty of Medical Parasitology in the same University in 2007. Her main research interests are the antimalarial drug resistance mechanisms and targets; Search for synthetic and natural compounds as new antimalarials; Development of molecular tools for monitoring drug resistance in Plasmodium spp. IHMT-NOVA tasks coordinator of the projects: CIRCNA/BRB/0281/2019_AMAZING; EuroNanoMed3-NANOpheles ref. 171129_ERA-Net_NANOpheles; COMPETE2020. SAICT/2019. REF:46871v; 2022.02426.PTDC; PTDC/MEDQUI/30021/2017; PTDC/BTM-SAL/29786/2017; PTDC/SAU-FAR/114864/2009 CRI and PTDC/QUI/65142/2006 and team member of EDCTP-RegNet2015-1049; Erasmus+ Programme. 586245-EPP-1-2017-1-FR-EPPKA2-CBHE-JP; PTDC/BIA-CEL/28456/2017; VIASEF FCT/P2020, FEDER.n.º2207 and PTDC/SAU-MET/110323/2009. CYTED REF: P215RT0054; CYTED REF: Red 210RT0398. As a PhD student participated in CORDIS/ EU. REF: QLK2-CT-2002-01503; FCT. POCTI/FCB/39218/2001; FCG contrato nº 65472; POCTI/ESP/39580/2001; POCTI/ESP/42666/2001; PRAXIS/P/SAU/14070/98; PRAXIS/PSAU/P/SAL/38/96; FCG contrato nº 54965; POCTI/MGI/36369/1999; PRAXIS/3.1/AdI/L1347. Holds 2 patents (https://novainnovation.unl.pt/2022/06/21/antimalarial-agent-methods-and-uses-thereof/; (https://novainnovation.unl.pt/2022/06/30/anti-infective-pyrazino-12-bquinazoline-36-diones-derivatives-and-their-production/). Integrated member of GHTM (UID/04413/2020) and LA-REAL (LA/P/0117/2020) and a collaborator member of LAQV-REQUIMTE (UIDB/50006/2020 I&D Unit). Scientific program evaluator of EU (Expert EX2016D276705) INFRAIA-01-2016-2017 and INFRAIA-02-2017 and of the Ministry of Higher Education, Science, Technology and Innovation of Angola ¿ 2020. Technical-scientific support (advisor) of: i) Molecular Biology Laboratory of Lubango Central Hospital (LBM-HCL), Angola since 2022; and ii) Medical Entomology Laboratory (LEM) of the National Institute of Public Health of Cape Verde (INSP) from 2018-2023. Associate Editor in the Anti-Infective Agents section of Frontiers in Drug Design and Discovery. Over the years, and has been contributing with peer review for more than 24 Journals. Co-authored over 94 papers in internationally indexed scientific journals, (69 indexed in SCOPUS) in the fields of malaria drug resistance and new antimalarials, with over 1000 citations and an h-index of 21 (SCOPUS database assessed 14/02/24). FN is a member of RSTMH (nº 0023123) and ASM (ID: 200343879; and a member of the ASM Subcommittee for Career Development Grant for Postdoctoral Women (CDGPW). Regularly maintains field research collaboration&training with CPLP countries (São Tomé and Principe, East Timor, Cape Verde, Angola, Mozambique and Brazil), Senegal and Thailand. Scientific advisory board member of the PhD program "Global Health and Infectious Diseases" at IHMT. Coordinates 4 curricular units (2 PhD and 2 MsC) and teaches in 2 PhD and 5 MSc programs at IHMT-NOVA. Supervisor of 10 PhD students (6 ongoing (Clemente Silva (Millenium BCP grant, Valéria Chicamba, FCG grant, Denise Duarte FCT 2022.12736.BD, Inês Morais FCT 2023.03356.BD, Mbueno Nzila, Rafael Dimbu, and 4 completed) and 25 MSc students (21 completed, 4 ongoing).

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Identificação

Identificação pessoal

Nome completo: MARIA DE FÁTIMA CARVALHO NOGUEIRA
Género: Feminino

Nomes de citação

nogueira, fatima
nogueira F

Identificadores de autor

Ciência ID: 7B1B-1ABB-1A16
ORCID iD: 0000-0003-0313-0778
Researcher Id: I-2148-2012
Scopus Author Id: 7006748317

Telefones

Telefone

213652626 Ext.: 361 (Profissional)

Domínios de atuação

Ciências Médicas e da Saúde - Ciências da Saúde - Parasitologia

Idiomas

Idioma	Conversação	Leitura	Escrita	Compreensão	Peer-review
Português (Idioma materno)
Espanhol; Castelhano	Utilizador proficiente (C2)	Utilizador proficiente (C2)	Utilizador proficiente (C2)	Utilizador proficiente (C2)	Utilizador proficiente (C2)
Inglês	Utilizador proficiente (C1)	Utilizador proficiente (C2)	Utilizador proficiente (C1)	Utilizador proficiente (C1)	Utilizador proficiente (C1)
Francês	Utilizador independente (B2)	Utilizador proficiente (C1)	Utilizador independente (B1)	Utilizador proficiente (C1)

Formação

	Grau	Classificação
2007 Concluído	DOUTORAMENTO (Doutoramento) Especialização em Medical Parasitology Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal "Estudos de biologia da multiresistência a antimaláricos em Plasmodium falciparum: transportadores ABC e genes de resposta ao stress oxidativo" (TESE/DISSERTAÇÃO)	muito bom
2001 Concluído	Mestrado em Parasitologia Médica (Mestrado) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal	Muito Bom
1998 Concluído	Parasitologia Médica (Especialização pós-licenciatura) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal	16
1996 Concluído	licenciatura em Biologia Microbiana e Genética (Licenciatura) Universidade de Lisboa Faculdade de Ciências, Portugal	14
1986 Concluído	Dietética e Nutrição (Licenciatura) Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal	15

Percurso profissional

Ciência

	Categoria Profissional Instituição de acolhimento	Empregador
2023/12/01 - Atual	Investigador principal (carreira) (Investigação)	Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
	Universidade Nova de Lisboa Saúde Global e Medicina Tropical, Portugal (...)
2007/03/01 - 2023/11/30	Investigador Auxiliar (carreira) (Investigação)	Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
	Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal (...)
2007/05/01 - 2007/07/31	Investigador visitante (Investigação)	Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
	Universidad Complutense de Madrid Facultad de Veterinaria, Espanha
2001 - 2007	Assistente de Investigação (carreira) (Investigação)	Universidade Nova de Lisboa, Portugal
	Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal (...)
1989 - 2001	Estagiário de Investigação (Investigação)	Hospital de Santa Marta, Portugal
	Hospital de Santa Marta, Portugal
1997/01/01 - 1997/12/31	Investigador visitante (Investigação)	Universidade de Lisboa Instituto Superior Tecnico Campus Tecnológico e Nuclear, Portugal
	Universidade de Lisboa Instituto Superior Tecnico Campus Tecnológico e Nuclear, Portugal

Outras Carreiras

	Categoria Profissional Instituição de acolhimento	Empregador
1989 - 1996	Assistente (Técnico Superior de Saúde - Nutrição)	Hospital de Santa Marta, Portugal

1989/08 - 1989/10	Assistente (Técnico Superior de Saúde - Nutrição)	Hospital CUF Tejo, Portugal

Projetos

Projeto

	Designação	Financiadores
2023/02/01 - Atual	A non-canonical protective response against malaria , Refª 2022.02426.PTDC 2022.02426.PTDC Investigador Universidade Nova de Lisboa Saúde Global e Medicina Tropical, Portugal The Johns Hopkins Hospital, Estados Unidos	Fundação para a Ciência e a Tecnologia Em curso
2019 - Atual	PYRAZINO [1,2-B]QUINAZOLINE-3,6-DIONES DERIVATIVES, THEIR PRODUCTION AND USES THEREOF REF:46871 REF: 46871 Co-Investigador Responsável (Co-IR) Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal	European Union Horizon 2020 Em curso
2018/10/01 - Atual	When the host cell is not so cosy anymore? A drop off in energy or an increase in toxicity? PTDC/BIA-CEL/28456/2017 Investigador Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2017/06/01 - Atual	VIASEF - In VIvo Arthropod SEcurity Facility FCT/P2020, FEDER. Project nº 22077 Investigador	Fundação para a Ciência e a Tecnologia
1999/01/01 - Atual	T-Cell response in pathogenesis of malaria infection POCTI/36369/MGI/1999 MsC student Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal Instituto Gulbenkian de Ciência, Portugal Institut Pasteur, França	Fundação para a Ciência e a Tecnologia Concluído
2021/01/01 - 2025/12/31	Translação e Inovação para a Saúde Global LA/P/0117/2020 10.54499/LA/P/0117/2020 Universidade Nova de Lisboa Saúde Global e Medicina Tropical, Portugal Universidade Nova de Lisboa, Portugal Universidade NOVA de Lisboa Comprehensive Health Research Centre, Portugal Universidade de Lisboa Faculdade de Medicina Dentária, Portugal Universidade de Coimbra, Portugal Universidade de Évora, Portugal Universidade Nova de Lisboa ¿Laboratório de Instrumentação Engenharia Biomédica e Física da Radiação, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2020/03/01 - 2023/12/31	AMAZING – AMAZonian snake toxins: creatING value from bioresources CIRCNA/BRB/0281/2019 Investigador Universidade Nova de Lisboa Saúde Global e Medicina Tropical, Portugal REQUIMTE LAQV Porto, Portugal Universidade do Porto, Portugal Instituto de Medicina Molecular João Lobo Antunes, Portugal Universidad Regional Amazónica IKIAM, Equador Universidad Tecnológica Indoamérica - Quito, Equador Universidade Estadual de Campinas, Brasil	Fundação para a Ciência e a Tecnologia Em curso
2018/10/04 - 2022/01/03	A small couple against the big three PTDC/BTM-SAL/29786/2017 Investigador Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal REQUIMTE LAQV Porto, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2018/10/01 - 2021/09/30	A multitarget strategy to hit all stages of the Plasmodium life-cycle PTDC/MED-QUI/30021/2017 Investigador Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal Universidade de Lisboa Faculdade de Farmácia, Portugal Instituto de Medicina Molecular João Lobo Antunes, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2018/03/01 - 2021/02/28	Development of nanovectors for the targeted delivery in Anopheles mosquitoes of agents blocking transmission of Plasmodium parasites 171129_ERA-Net_NANOpheles Investigador Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal Instituto de Salud Global Barcelona, Espanha Universiteit Twente, Países Baixos Université de Liège, Bélgica	European Regional Development Fund Concluído
2019/01/01 - 2019/12/31	Saúde Global e Medicina Tropical UID/Multi/04413/2019 Universidade Nova de Lisboa Saúde Global e Medicina Tropical, Portugal Universidade Nova de Lisboa, Portugal Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2011/04/01 - 2014/09/30	Disorders on the Glycolytic and Pentose Phosphate Pathways of the Red Blood Cell - how do they affect Plasmodium infection? PTDC/SAU-MET/110323/2009 Investigador Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2011/03/01 - 2014/08/31	TARGETING HEMOZOIN CRYSTAL STRUCTURE: A RATIONAL APPROACH TO THE DESIGN OF NOVEL ANTIMALARIALS PTDC/SAU-FAR/114864/2009 Investigador Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal Universidade de Lisboa Faculdade de Farmácia, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2010/01/01 - 2013/12/31	Proteómica y quimiogenómica de inhibidores de proteasas de origen natural con potencial terapéutico en malaria UNESCO 230221, 2415, 230227, 230222, 239001, 320719 Investigador Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal Universidad Nacional de la Plata Facultad de Ciencias Exactas, Argentina	Ciencia y Tecnología para el Desarrollo Concluído
2011/01/01 - 2012/12/31	Projecto Estratégico - LA 18 - 2011-2012 PEst-OE/SAU/LA0018/2011 Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2011/01/01 - 2012/12/30	Caracterização bioquímica e envolvimento farmacológico de metaloproteinases isoladas do parasita Trypanosoma brucei FCT-CAPES 2011-2012 Investigador Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal Universidade Federal do Rio Grande do Norte Centro de Biociências, Brasil	Fundação para a Ciência e a Tecnologia Concluído
2009/01/01 - 2012/04/30	Recycling antimalarials: rational design of novel 8-aminoquinoline analogues with gametocytocidal and blood-schizontocidal activity PTDC/QUI/65142/2006 Investigador Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal Universidade do Porto Faculdade de Ciências, Portugal Universidade de Lisboa Faculdade de Farmácia, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2011 - 2012	Defining the role and extent of protein glycosylation in the malaria causing parasite Plasmodium falciparum Projectos CMDT /IHMT Projectos CMDT /IHMT Investigador Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal Centro de Investigación en Salud Internacional de Barcelona, Espanha Instituto de Salud Global Barcelona, Espanha	Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical Concluído
2003/01/01 - 2006/06/30	Development of a malaria resistance DNA chip as a public health tool for the management of Plasmodium falciparum malaria drug resistance QLK2-CT-2002-01503 PhD Student Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal Schweizerisches Tropen- und Public Health-Institut, Suiça Institut Pasteur, França Institut Pasteur de la Guyane, Guiana Francesa Institut Pasteur de Madagascar, Madagáscar Institut Pasteur du Cambodge, Camboja Institut Pasteur de Dakar, Senegal	European Union Concluído
2002/04/01 - 2005/04/01	Studies on the human host pharmacogenetics and the use of antimalarials POCTI/ESP/39580/2001 PhD Student Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2002/03/31 - 2005/03/31	A new approach to antimalarial therapy. Novel chemical delivery systems for primaquine and amodiaquine POCTI/FCB/39218/2001 PhD Student Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2004/08/04 - 2005/02/04	Can Malarone® be recommended as antimalarial prophylaxis for PALOP cuntries? Search for mutations in the Plasmodium falciparum cytochrome b gene associated with resistance to Malarone® in Angola, Mozambique and S. Tomé and Príncipe FCG Investigador Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal	Fundação Calouste Gulbenkian Concluído
2002/02 - 2005/02	Studies on the genetics of drug resistance in malaria POCTI/ESP/42666/2001 PhD Student	Fundação para a Ciência e a Tecnologia
2002/01/01 - 2004/01/01	Proteases of malaria parasites targets for chemoterapy POCTI/ESP/42233/2001 PhD Student Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal	Fundação para a Ciência e a Tecnologia Concluído

Produções

Publicações

Artigo em revista	Ana Figueiredo; nogueira, fatima; Katherine de Villiers; António G. Goncalves de Sousa; Lasse Votborg-Nóvel; Cäcilie von Wedel; Pinkus Tober-Lau; et al. "A Metabolite-Based Resistance Mechanism Against Malaria". Nature (2024): Em revisão Livia M. Feitosa; Rodolfo Rodrigo F. Franca; Maria de Lourdes G. Ferreira; Anna C.C. Aguiar; Guilherme E. de Souza; Sarah El Chamy Maluf; Juliana O. de Souza; et al. "Discovery of new piperaquine hybrid analogs linked by triazolopyrimidine and pyrazolopyrimidine scaffolds with antiplasmodial and transmission blocking activities". European Journal of Medicinal Chemistry (2024): http://dx.doi.org/10.1016/j.ejmech.2024.116163. 10.1016/j.ejmech.2024.116163 Ana M. Ferreira; Isabela Sales; Sónia A. O. Santos; Tiago Santos; Fátima Nogueira; Silvana Mattedi; Simão P. Pinho; João A. P. Coutinho; Mara G. Freire. "Enhanced Antimalarial Activity of Extracts of Artemisia annua L. Achieved with Aqueous Solutions of Salicylate Salts and Ionic Liquids". Chem & Bio Engineering (2024): https://doi.org/10.1021/cbe.3c00005. 10.1021/cbe.3c00005 Iranildo José da Cruz Filho; Denise Maria Figueiredo Araújo Duarte; Diego Santa Clara Marques; João Victor Ritinto da Rocha; Emily Gabriele Marques Diniz; Fábio André Brayner; Luiz Carlos Alves; et al. "Evaluation of the hydroalcoholic extract of Clarisia racemosa as an antiparasitic agent: an in vitro approach". 3 Biotech (2023): http://dx.doi.org/10.1007/s13205-023-03799-2. 10.1007/s13205-023-03799-2 Gustavo da Silva; André F. S. Luz; Denise Duarte; Diana Fontinha; Vera L. M. Silva; Filipe A. Almeida Paz; Ana M. Madureira; et al. "Facile Access to Structurally Diverse Antimalarial Indoles Using a One-Pot A³ Coupling and Domino Cyclization Approach". ChemMedChem (2023): http://dx.doi.org/10.1002/cmdc.202300264. 10.1002/cmdc.202300264 CLEMENTE DA SILVA; Daniela Matias; Brigite Dias; Beatriz Cancio; Miguel Silva; Ruben Viegas; Nordino Chivale; et al. "Anti-malarial resistance in Mozambique: Absence of Plasmodium falciparum Kelch 13 (K13) propeller domain polymorphisms associated with resistance to artemisinins". Malaria Journal 22 1 (2023): http://dx.doi.org/10.1186/s12936-023-04589-0. 10.1186/s12936-023-04589-0 Natali de França Nibbering Santos; Natanael da Silva Bezerra Junior; Jamerson Ferreira de Oliveira; Denise Maria Figueiredo Araújo Duarte; José Cleberson dos Santos Soares; Diego Santa Clara Marques; Aline Caroline da Silva Santos; et al. "Synthesis, characterization, antioxidant and antiparasitic activities new naphthyl-thiazole derivatives". Experimental Parasitology 248 (2023): 108498-108498. http://dx.doi.org/10.1016/j.exppara.2023.108498. 10.1016/j.exppara.2023.108498 José Rafael Almeida; Ana Gomes; Bruno Mendes; Luísa Aguiar; Mariana Ferreira; Mariana Borges Costa Brioschi; Denise Duarte; et al. "Unlocking the potential of snake venom-based molecules against the malaria, Chagas disease, and leishmaniasis triad". International Journal of Biological Macromolecules (2023): 124745-124745. http://dx.doi.org/10.1016/j.ijbiomac.2023.124745. 10.1016/j.ijbiomac.2023.124745 Iranildo José da Cruz Filho; Denise Maria Figueiredo Araujo Duarte; Douglas da Conceição Alves de Lima; Diego Santa Clara Marques; Fábio André Brayner dos Santos; Luiz Carlos Alves; André de Lima Aires; Fátima Nogueira; Maria do Carmo Alves de Lima. "In vitro evaluation of alkaline lignins as antiparasitic agents and their use as an excipient in the release of benznidazole". International Journal of Biological Macromolecules 231 (2023): 123339-123339. http://dx.doi.org/10.1016/j.ijbiomac.2023.123339. 10.1016/j.ijbiomac.2023.123339 Silva, A.T.; Oliveira, I.S.; Gomes, J.; Aguiar, L.; Fontinha, D.; Duarte, D.; Nogueira, F.; et al. "Corrigendum to: Drug-Derived Surface-Active Ionic Liquids: A Cost-Effective Way To Expressively Increase the Blood-Stage Antimalarial Activity of Primaquine (ChemMedChem, (2022), 17, 5, 10.1002/cmdc.202100650)". ChemMedChem 18 1 (2023): http://www.scopus.com/inward/record.url?eid=2-s2.0-85143608295&partnerID=MN8TOARS. 10.1002/cmdc.202200589 BEATRIZ R.M.G. DA SILVA; NATANAEL DA SILVA BEZERRA JÚNIOR; JAMERSON F. DE OLIVEIRA; DENISE MARIA F.A. DUARTE; DIEGO S.C. MARQUES; FÁTIMA NOGUEIRA; MARIA CARMO A. DE LIMA; IRANILDO JOSÉ DA CRUZ FILHO. "In silico ADMET prediction, evaluation of cytotoxicity in mouse splenocytes and preliminary evaluation of in vitro antimalarial activity of 4-(4-chlorophenyl)thiazole compounds". Anais da Academia Brasileira de Ciências (2023): https://doi.org/10.1590/0001-3765202320230566. 10.1590/0001-3765202320230566 Araújo, Denise Maria Figueiredo; da Cruz Filho, Iranildo José; Santos, Tiago; Pereira, Daniel Tarciso Martins; Marques, Diego Santa Clara; da Conceição Alves de Lima, Alice; de Aquino, Thiago Mendonça; et al. "Biological activities and physicochemical characterization of alkaline lignins obtained from branches and leaves of Buchenavia viridiflora with potential pharmaceutical and biomedical applications". International Journal of Biological Macromolecules 219 (2022): 224-245. http://dx.doi.org/10.1016/j.ijbiomac.2022.07.225. Publicado • 10.1016/j.ijbiomac.2022.07.225 Ramos S; Ademolue TW; Jentho E; Wu Q; Guerra J; Martins R; Pires G; et al. "A hypometabolic defense strategy against malaria.". Cell metabolism (2022): http://europepmc.org/abstract/med/35841892. 10.1016/j.cmet.2022.06.011 Morais I; Medeiros MM; Carvalho M; Morello J; Teixeira SM; Maciel S; Nhantumbo J; et al. "Synthetic Red Blood Cell-Specific Glycolytic Intermediate 2,3-Diphosphoglycerate (2,3-DPG) Inhibits Plasmodium falciparum Development In Vitro.". Frontiers in cellular and infection microbiology (2022): http://europepmc.org/abstract/med/35372095. 10.3389/fcimb.2022.840968 Rafael F. A. Gomes; Joao M. J. M. Ravasco; Késsia H. S. Andrade; Jaime A. S. Coelho; Rui Moreira; Rafael Oliveira; Fátima Nogueira; Carlos A. M. Afonso. "Tandem Thio-Michael Addition/Remote Lactone Activation of 5-Hydroxymethylfurfural-Derived d-Lactone-Fused Cyclopentenones". ChemSusChem (2022): https://doi.org/10.1002/cssc.202102204. 10.1002/cssc.202102204 "Indole-Containing Pyrazino[2,1-b]quinazoline-3,6-diones Active against Plasmodium and Trypanosomatids". ACS Medicinal Chemistry Letters (2022): http://dx.doi.org/10.1021/acsmedchemlett.1c00589. 10.1021/acsmedchemlett.1c00589 Silva AT; Oliveira IS; Gomes J; Aguiar L; Fontinha D; Duarte D; Nogueira F; et al. "Drug-Derived Surface-Active Ionic Liquids: A Cost-Effective Way To Expressively Increase the Blood-Stage Antimalarial Activity of Primaquine.". ChemMedChem (2021): http://europepmc.org/abstract/med/34882979. 10.1002/cmdc.202100650 Debora Serrano; Ana Santos-Reis; Clemente Silva; Ana Dias; Brigite Dias; Cristina Toscano; Cláudia Conceição; Teresa Baptista-Fernandes; Fatima Nogueira. "Imported Malaria in Portugal: Prevalence of Polymorphisms in the Anti-Malarial Drug Resistance Genes pfmdr1 and pfk13". Microorganisms (2021): https://doi.org/10.3390/microorganisms9102045. 10.3390/microorganisms9102045 Silva-Pinto A; Domingos J; Cardoso M; Reis A; Benavente ED; Caldas JP; Conceição C; et al. "Artemether-lumefantrine treatment failure of uncomplicated Plasmodium falciparum malaria in travellers coming from Angola and Mozambique.". International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases (2021): http://europepmc.org/abstract/med/34242769. 10.1016/j.ijid.2021.07.008 Ambroise Ahouidi; Luzia Helena Carvalho; Rafael Oliveira; Lis Lobo; Cyrille Diedhiou; Souleymane Mboup; Fatima Nogueira. "Prevalence of pfk13 and pfmdr1 polymorphisms in Bounkiling, Southern Senegal". PLOS ONE (2021): https://doi.org/10.1371/journal.pone.0249357. 10.1371/journal.pone.0249357 Da Veiga Leal S; Ward D; Campino S; Benavente ED; Ibrahim A; Claret T; Isaías V; et al. "Drug resistance profile and clonality of Plasmodium falciparum parasites in Cape Verde: the 2017 malaria outbreak.". Malaria journal (2021): http://europepmc.org/abstract/med/33789667. 10.1186/s12936-021-03708-z Sofia A. Milheiro; Joana Gonçalves; Ricardo M. R. M. Lopes; Margarida Madureira; Lis Lobo; Andreia Lopes; Fátima Nogueira; et al. "Half-Sandwich Cyclopentadienylruthenium(II) Complexes: A New Antimalarial Chemotype". Inorganic Chemistry 59 17 (2020): 12722-12732. https://doi.org/10.1021/acs.inorgchem.0c01795. 10.1021/acs.inorgchem.0c01795 Elena Lantero; Jessica Fernandes; Carlos Raúl Aláez-Versón; Joana Gomes; Henrique Silveira; Fatima Nogueira; Xavier Fernàndez-Busquets. "Heparin Administered to Anopheles in Membrane Feeding Assays Blocks Plasmodium Development in the Mosquito". Biomolecules (2020): https://doi.org/10.3390/biom10081136. 10.3390/biom10081136 Gomes PATM; Cardoso MVO; Santos IR; Sousa F; Conceição J; Silva V; Duarte D; et al. "Dual Parasiticidal Activities of New Phthalimides: Synthesis and Biological Profile against Trypanosoma cruzi and Plasmodium falciparum.". ChemMedChem (2020): http://europepmc.org/abstract/med/32813331. 10.1002/cmdc.202000331 Ana Teresa Silva; Lis Lobo; Isabel S. Oliveira; Joana Gomes; Cátia Teixeira; Fátima Nogueira; Eduardo F. Marques; Ricardo Ferraz; Paula Gomes. "Building on Surface-Active Ionic Liquids for the Rescuing of the Antimalarial Drug Chloroquine". International Journal of Molecular Sciences 21 15 (2020): 5334-5334. https://doi.org/10.3390/ijms21155334. 10.3390/ijms21155334 Valério, Gabriel N.; Gutiérrez-Merino, Carlos; Nogueira, Fatima; Moura, Isabel; Moura, José J.G.; Samhan-Arias, Alejandro K.. "Human erythrocytes exposure to juglone leads to an increase of superoxide anion production associated with cytochrome b5 reductase uncoupling". Biochimica et Biophysica Acta (BBA) - Bioenergetics 1861 2 (2020): 148134. http://dx.doi.org/10.1016/j.bbabio.2019.148134. Publicado • 10.1016/j.bbabio.2019.148134 Luísa Aguiar; Arnau Biosca; Elena Lantero; Jiri Gut; Nuno Vale; Philip J. Rosenthal; Fátima Nogueira; et al. "Coupling the Antimalarial Cell Penetrating Peptide TP10 to Classical Antimalarial Drugs Primaquine and Chloroquine Produces Strongly Hemolytic Conjugates". Molecules 24 24 (2019): 4559-4559. https://doi.org/10.3390/molecules24244559. 10.3390/molecules24244559 Ruiz Moreno, Yorleydy; Donato, Silvia Tavares; Nogueira, Fátima; Sousa Silva, Marcelo. "Comparative Analysis of the Serological Reactivity of Individuals with Clinical History of Malaria using Two Different ELISA Tests". Diagnostics 9 4 (2019): 168. http://dx.doi.org/10.3390/diagnostics9040168. Publicado • 10.3390/diagnostics9040168 Lobo, Lis; Cabral, Lília I. L.; Sena, Maria Inês; Guerreiro, Bruno; Rodrigues, António Sebastião; de Andrade-Neto, Valter Ferreira; Cristiano, Maria L. S.; Nogueira, Fatima. "New endoperoxides highly active in vivo and in vitro against artemisinin-resistant Plasmodium falciparum". Malaria Journal 17 1 (2018): http://dx.doi.org/10.1186/s12936-018-2281-x. 10.1186/s12936-018-2281-x Domingos J; Casimiro A; Portugal-Calisto D; Varandas L; Nogueira F; Silva MS. "Clinical, laboratorial and immunological aspects of severe malaria in children from Guinea-Bissau.". Acta tropica (2018): http://europepmc.org/abstract/med/29684356. 10.1016/j.actatropica.2018.04.020 De Sena Pereira, V.S.; Da Silva Emery, F.; Lobo, L.; Nogueira, F.; Oliveira, J.I.N.; Fulco, U.L.; Albuquerque, E.L.; Katzin, A.M.; De Andrade-Neto, V.F.. "In vitro antiplasmodial activity, pharmacokinetic profiles and interference in isoprenoid pathway of 2-aniline-3-hydroxy-1.4-naphthoquinone derivatives". Malaria Journal 17 1 (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85058884809&partnerID=MN8TOARS. 10.1186/s12936-018-2615-8 Horta, P.; Henriques, M.S.C.; Brás, E.M.; Murtinheira, F.; Nogueira, F.; O'Neill, P.M.; Paixaõ, J.A.; et al. "On the ordeal of quinolone preparation via cyclisation of aryl-enamines; Synthesis and structure of ethyl 6-methyl-7-iodo-4-(3-iodo-4-methylphenoxy)-quinoline-3-carboxylate". Pure and Applied Chemistry 89 6 (2017): 765-780. http://www.scopus.com/inward/record.url?eid=2-s2.0-85020515500&partnerID=MN8TOARS. 10.1515/pac-2016-1119 Lobo L; Sousa Bd; Cabral L; Cristiano ML; Nogueira F; Lobo, L.; de Sousa, B.; et al. "Highly active ozonides selected against drug resistant malaria.". Memorias do Instituto Oswaldo Cruz 111 7 (2016): 450-453. http://europepmc.org/abstract/med/27276364. 10.1590/0074-02760160077 nogueira, fatima. "Whole-Cell SYBR Green I Assay for Antimalarial Activity Assessment". (2016): https://www.jscimedcentral.com/MedicalMicrobiology/medicalmicrobiology-2-1010.pdf. Ferraz, R.; Noronha, J.; Murtinheira, F.; Nogueira, F.; Machado, M.; Prudêncio, M.; Parapini, S.; et al. "Primaquine-based ionic liquids as a novel class of antimalarial hits". RSC Advances 6 61 (2016): 56134-56138. http://www.scopus.com/inward/record.url?eid=2-s2.0-84975078549&partnerID=MN8TOARS. 10.1039/c6ra10759a M Machado; F Murtinheira; E Lobo; f nogueira. "Whole-cell SYBR Green I assay for antimalarial activity assessment". Annals of Clinical and Medical Microbiology 2 (2016): https://novaresearch.unl.pt/en/publications/bf8be0c0-a719-4d50-8b20-d8579f2e3b2b. Figueiras M; Coelho L; Wicht KJ; Santos SA; Lavrado J; Gut J; Rosenthal PJ; et al. "N10,N11-di-alkylamine indolo[3,2-b]quinolines as hemozoin inhibitors: Design, synthesis and antiplasmodial activity.". (2015): http://europepmc.org/abstract/med/25725608. 10.1016/j.bmc.2015.02.007 Faísca Phillips AM; Nogueira F; Murtinheira F; Barros MT. "Synthesis and antimalarial evaluation of prodrugs of novel fosmidomycin analogues.". (2015): http://europepmc.org/abstract/med/25881827. 10.1016/j.bmcl.2015.03.077 Escobar C; Pateira S; Lobo E; Lobo L; Teodosio R; Dias F; Fernandes N; et al. "Polymorphisms in Plasmodium falciparum K13-Propeller in Angola and Mozambique after the Introduction of the ACTs.". (2015): http://europepmc.org/abstract/med/25789669. 10.1371/journal.pone.0119215 Santos, S.A.; Lukens, A.K.; Coelho, L.; Nogueira, F.; Wirth, D.F.; Mazitschek, R.; Moreira, R.; et al. "Exploring the 3-piperidin-4-yl-1H-indole scaffold as a novel antimalarial chemotype". European Journal of Medicinal Chemistry 102 (2015): 320-333. http://www.scopus.com/inward/record.url?eid=2-s2.0-84939606151&partnerID=MN8TOARS. 10.1016/j.ejmech.2015.07.047 Gomes, A.; Machado, M.; Lobo, L.; Nogueira, F.; Prudêncio, M.; Teixeira, C.; Gomes, P.; et al. "N-Cinnamoylation of Antimalarial Classics: Effects of Using Acyl Groups Other than Cinnamoyl toward Dual-Stage Antimalarials". ChemMedChem 10 8 (2015): 1344-1349. http://www.scopus.com/inward/record.url?eid=2-s2.0-84937978987&partnerID=MN8TOARS. 10.1002/cmdc.201500164 Horta, P.; Kus, N.; Henriques, M.S.C.; Paixão, J.A.; Coelho, L.; Nogueira, F.; O'Neill, P.M.; et al. "Quinolone-Hydroxyquinoline Tautomerism in Quinolone 3-Esters. Preserving the 4-Oxoquinoline Structure To Retain Antimalarial Activity". Journal of Organic Chemistry 80 24 (2015): 12244-12257. http://www.scopus.com/inward/record.url?eid=2-s2.0-84952802726&partnerID=MN8TOARS. 10.1021/acs.joc.5b02169 Portugal-Calisto, D.; Teodosio, R.; Nogueira, F.; Silva, M. Sousa. "Immunological characterization of antibodies and antigens of Plasmodium falciparum in plasma samples obtained from individuals who previously stayed in malaria-endemic areas". Tropical Medicine & International Health (2015): https://publons.com/publon/13993993/. Carrasco MP; Newton AS; Gonçalves L; Góis A; Machado M; Gut J; Nogueira F; et al. "Probing the aurone scaffold against Plasmodium falciparum: design, synthesis and antimalarial activity.". (2014): http://europepmc.org/abstract/med/24813880. 10.1016/j.ejmech.2014.04.076 Paulo A; Figueiras M; Machado M; Charneira C; Lavrado J; Santos SA; Lopes D; et al. "Bis-alkylamine Indolo[3,2-b]quinolines as hemozoin ligands: implications for antimalarial cytostatic and cytocidal activities.". (2014): http://europepmc.org/abstract/med/24673163. 10.1021/jm500075d Miranda D; Capela R; Albuquerque IS; Meireles P; Paiva I; Nogueira F; Amewu R; et al. "Novel endoperoxide-based transmission-blocking antimalarials with liver- and blood-schizontocidal activities.". (2014): http://europepmc.org/abstract/med/24900781. 10.1021/ml4002985 Gomes A; Pérez B; Albuquerque I; Machado M; Prudêncio M; Nogueira F; Teixeira C; Gomes P. "N-cinnamoylation of antimalarial classics: quinacrine analogues with decreased toxicity and dual-stage activity.". (2014): http://europepmc.org/abstract/med/24474655. 10.1002/cmdc.201300459 Marques MM; Costa MR; Santana Filho FS; Vieira JL; Nascimento MT; Brasil LW; Nogueira F; et al. "Plasmodium vivax Chloroquine Resistance and Anemia in the Western Brazilian Amazon.". (2014): http://europepmc.org/abstract/med/24165179. 10.1128/AAC.02279-12 Lobo E; de Sousa B; Rosa S; Figueiredo P; Lobo L; Pateira S; Fernandes N; Nogueira F. "Prevalence of pfmdr1 alleles associated with artemether-lumefantrine tolerance/resistance in Maputo before and after the implementation of artemisinin-based combination therapy.". (2014): http://europepmc.org/abstract/med/25098280. 10.1186/1475-2875-13-300 Machado P; Vaz TR; Nogueira F; Rodrigues J; Manco L; Ribeiro L; Bergstrom E; et al. "Quantitative proteomics for the analysis of Plasmodium falciparum and its red blood cell host - a preliminary study.". (2014): http://europepmc.org/abstract/PMC/PMC4179439. Arez, Ana Paula; Henrique Silveira; f nogueira. "Mais de meio século da investigação de malária no IHMT". Anais do Instituto de Higiene e Medicina Tropical 13 (2014): 7-17. https://novaresearch.unl.pt/en/publications/d390f3d3-677a-4ba7-9842-cc05fe600ef0. https://doi.org/10.25761/anaisihmt.165 P. A. Carvalho; L. Coelho; R. C. Martins; f nogueira. "Differences between synthetic ß-haematin and native hemozoin crystals.". Microscopy and Microanalysis 19 Suppl. 4 (2013): 49-50. https://novaresearch.unl.pt/en/publications/dd50f455-6af8-4ebc-8395-5cce75e2a756. Costa, R.M.; Nogueira, F.; De Sousa, K.P.; Vitorino, R.; Silva, M.S.; Costa RM; Nogueira F; et al. "Immunoproteomic analysis of Plasmodium falciparum antigens using sera from patients with clinical history of imported malaria". Malaria Journal 12 1 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84875026266&partnerID=MN8TOARS. 10.1186/1475-2875-12-100 Chehuan, Y.F.; Costa, M.R.; Costa, J.S.; Alecrim, M.G.; Nogueira, F.; Silveira, H.; Brasil, L.W.; et al. "In vitro chloroquine resistance for Plasmodium vivax isolates from the Western Brazilian Amazon". Malaria Journal 12 1 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84879835113&partnerID=MN8TOARS. 10.1186/1475-2875-12-226 Matos, J.; Da Cruz, F.P.; Cabrita, É.; Gut, J.; Nogueira, F.; Do Rosário, V.E.; Moreira, R.; et al. "Novel potent metallocenes against liver stage malaria". Antimicrobial Agents and Chemotherapy 56 3 (2012): 1564-1570. http://www.scopus.com/inward/record.url?eid=2-s2.0-84857165822&partnerID=MN8TOARS. 10.1128/AAC.05345-11 Goncalves, E.; Marques, C.; Nogueira, F.; Rosario, V.; Ribeiro, V.. "Regulation of drugs metabolizing enzymes and transporters in mouse liber by primaquine". The FEBS Journal (2012): https://publons.com/publon/13993948/. Albuquerque, D.; Manco, L.; Loua, K.M.; Arez, A.P.; De Jesus Trovoada, M.; Relvas, L.; Millimono, T.S.; et al. "SLC40A1 Q248H allele frequencies and associated SLC40A1 haplotypes in three West African population samples". Annals of Human Biology 38 3 (2011): 378-381. http://www.scopus.com/inward/record.url?eid=2-s2.0-79953084701&partnerID=MN8TOARS. 10.3109/03014460.2010.541496 "Therapeutic efficacy of Coartem (R) for the treatment of uncomplicated malaria in Maputo, Mozambique". Tropical Medicine & International Health (2011): https://publons.com/publon/7749080/. Fátima Nogueira; Virgílio Estólio do Rosário. "Methods for assessment of antimalarial activity in the different phases of the Plasmodium life cycle". Revista Pan-Amazônica de Saúde 1 3 (2010): http://dx.doi.org/10.5123/s2176-62232010000300015. 10.5123/s2176-62232010000300015 Nogueira, F.; Diez, A.; Radfar, A.; Pérez-Benavente, S.; Rosario, V.E.d.; Puyet, A.; Bautista, J.M.. "Early transcriptional response to chloroquine of the Plasmodium falciparum antioxidant defence in sensitive and resistant clones". Acta Tropica 114 2 (2010): 109-115. http://www.scopus.com/inward/record.url?eid=2-s2.0-77649185865&partnerID=MN8TOARS. 10.1016/j.actatropica.2010.01.013 Manco, L.; Machado, P.; Lopes, D.; Nogueira, F.; Do Rosário, V.E.; Alonso, P.L.; Varandas, L.; et al. "Analysis of TPI gene promoter variation in three sub-Saharan Africa population samples". American Journal of Human Biology 21 1 (2009): 118-120. http://www.scopus.com/inward/record.url?eid=2-s2.0-59549103434&partnerID=MN8TOARS. 10.1002/ajhb.20819 Vale, N.; Prudêncio, M.; Marques, C.A.; Collins, M.S.; Gut, J.; Nogueira, F.; Matos, J.; et al. "Imidazoquines as antimalarial and antipneumocystis agents". Journal of Medicinal Chemistry 52 23 (2009): 7800-7807. http://www.scopus.com/inward/record.url?eid=2-s2.0-72249095184&partnerID=MN8TOARS. 10.1021/jm900738c Vale, N.; Nogueira, F.; do Rosário, V.E.; Gomes, P.; Moreira, R.. "Primaquine dipeptide derivatives bearing an imidazolidin-4-one moiety at the N-terminus as potential antimalarial prodrugs". European Journal of Medicinal Chemistry 44 6 (2009): 2506-2516. http://www.scopus.com/inward/record.url?eid=2-s2.0-64249118390&partnerID=MN8TOARS. 10.1016/j.ejmech.2009.01.018 f nogueira; Dinora Lopes; Ana Catarina Alves; Virgilio Estólio do Rosário. "Plasmodium falciparum multidrug resistance protein (MRP) gene expression under chloroquine and mefloquine challenge". Journal of Cell and Animal Biology 2 1 (2008): 010-020. https://novaresearch.unl.pt/en/publications/d5c07332-2a95-44f8-b159-fe09025d6efa. Vale, N.; Matos, J.; Gut, J.; Nogueira, F.; do Rosário, V.; Rosenthal, P.J.; Moreira, R.; Gomes, P.. "Imidazolidin-4-one peptidomimetic derivatives of primaquine: Synthesis and antimalarial activity". Bioorganic and Medicinal Chemistry Letters 18 14 (2008): 4150-4153. http://www.scopus.com/inward/record.url?eid=2-s2.0-47149096687&partnerID=MN8TOARS. 10.1016/j.bmcl.2008.05.076 Figueiredo, P.; Benchimol, C.; Lopes, D.; Bernardino, L.; Do Rosário, V.E.; Varandas, L.; Nogueira, F.. "Prevalence of pfmdr1, pfcrt, pfdhfr and pfdhps mutations associated with drug resistance, in Luanda, Angola". Malaria Journal 7 (2008): http://www.scopus.com/inward/record.url?eid=2-s2.0-58149241174&partnerID=MN8TOARS. 10.1186/1475-2875-7-236 Andrade-Neto, V.F.; Brandão, M.G.L.; Nogueira, F.; Rosário, V.E.; Krettli, A.U.. "Corrigendum to "Ampelozizyphus amazonicus Ducke (Rhamnaceae), a medicinal plant used to prevent malaria in the Amazon Region, hampers the development of Plasmodium berghei sporozoites" in [Int. J. Parasitol. 38 (2008) 1505-1511] (DOI:10.1016/j.ijpara.2008.05.007)". International Journal for Parasitology 38 14 (2008): http://www.scopus.com/inward/record.url?eid=2-s2.0-55249104306&partnerID=MN8TOARS. 10.1016/S0020-7519(08)00399-8 Andrade-Neto, V.F.; Brandão, M.G.L.; Nogueira, F.; Rosário, V.E.; Krettli, A.U.. "Ampelozyziphus amazonicus Ducke (Rhamnaceae), a medicinal plant used to prevent malaria in the Amazon Region, hampers the development of Plasmodium berghei sporozoites". International Journal for Parasitology 38 13 (2008): 1505-1511. http://www.scopus.com/inward/record.url?eid=2-s2.0-53049088303&partnerID=MN8TOARS. 10.1016/j.ijpara.2008.05.007 Portela, C.; Afonso, C.M.M.; Pinto, M.M.M.; Lopes, D.; Nogueira, F.; do Rosário, V.. "Synthesis and antimalarial properties of new chloro-9H-xanthones with an aminoaikyl side chain". Chemistry and Biodiversity 4 7 (2007): 1508-1519. http://www.scopus.com/inward/record.url?eid=2-s2.0-34547553741&partnerID=MN8TOARS. 10.1002/cbdv.200790130 Nogueira, F.; Gil, J.P.; Rosário, V.E.. "Efflux pumps of antimalarial-resistance in Plasmodium falciparum". Antibiotiques 8 2 (2006): 85-92. https://www.sciencedirect.com/science/article/pii/S1294550106708020. Publicado • 10.1016/S1294-5501(06)70802-0 Pimentel, S.; Nogueira, F.; Benchimol, C.; Quinhentos, V.; Bom, J.; Varandas, L.; Do Rosário, V.; Bernardino, L.. "Detection of atovaquone-proguanil resistance conferring mutations in Plasmodium falciparum cytochrome b gene in Luanda, Angola". Malaria Journal 5 (2006): http://www.scopus.com/inward/record.url?eid=2-s2.0-33746322417&partnerID=MN8TOARS. 10.1186/1475-2875-5-30 "Efflux pumps of antimalarial-resistance in Plasmodium falciparum". Antibiotiques (2006): https://publons.com/publon/15915951/. 10.1016/S1294-5501(06)70802-0 "Abstracts of the 7th European Congress of Chemotherapy and Infection, October 19-22, 2005, Florence, Italy.". Journal of chemotherapy (Florence, Italy) (2005): Dahlstrom, S.; Sisowath, C.; Nogueira, F.; Martensson, A.; Bjoerkman, A.; Gil, J.. "Size variations in a P. falciparu multidrug resistance protein (PfMRP) homologue and Coartem and artesunate plus amodiaquine clinical response [MIM-SD-175726]". Acta Tropica (2005): https://publons.com/publon/21941270/. "Abstracts of the 6th European Congress of Chemotherapy and Infection and the 24th Interdisciplinary Meeting of Anti-Infection Chemotherapy. 1-3 December 2004, Paris, France.". International journal of antimicrobial agents (2004): Ferreira, I.D.; Nogueira, F.; Borges, S.T.; Do Rosário, V.E.; Cravo, P.. "Is the expression of genes encoding enzymes of glutathione (GSH) metabolism involved in chloroquine resistance in Plasmodium chabaudi parasites?". Molecular and Biochemical Parasitology 136 1 (2004): 43-50. http://www.scopus.com/inward/record.url?eid=2-s2.0-2342479718&partnerID=MN8TOARS. 10.1016/j.molbiopara.2004.02.008 Bagot, S.; Nogueira, F.; Collette, A.; Do Rosario, V.; Lemonier, F.; Cazenave, P.-A.; Pied, S.. "Comparative Study of Brain CD8+ T Cells Induced by Sporozoites and Those Induced by Blood-Stage Plasmodium berghei ANKA Involved in the Development of Cerebral Malaria". Infection and Immunity 72 5 (2004): 2817-2826. http://www.scopus.com/inward/record.url?eid=2-s2.0-2142652154&partnerID=MN8TOARS. 10.1128/IAI.72.5.2817-2826.2004 Cravo, P.; Figueiredo, S.; Nogueira, F.; Lopes, D.; Ferreira, I.D.; Ferreira, C.; Gil, J.P.; Do Rosário, V.E.. "High frequency of the genetic polymorphisms associated with sulfadoxine-pyrimethamine resistance, among Plasmodium falciparum isolates from São Tomé and Príncipe, West Africa". Annals of Tropical Medicine and Parasitology 98 3 (2004): 293-296. http://www.scopus.com/inward/record.url?eid=2-s2.0-2342612193&partnerID=MN8TOARS. 10.1179/000349804225003262 Gil, J.P.; Nogueira, F.; Strömberg-Nörklit, J.; Lindberg, J.; Carrolo, M.; Casimiro, C.; Lopes, D.; et al. "Detection of atovaquone and Malarone™ resistance conferring mutations in Plasmodium falciparum cytochrome b gene (cytb)". Molecular and Cellular Probes 17 2-3 (2003): 85-89. http://www.scopus.com/inward/record.url?eid=2-s2.0-12444295411&partnerID=MN8TOARS. 10.1016/S0890-8508(03)00006-9 Lopes D; Rungsihirunrat K; Nogueira F; Seugorn A; Gil JP; do Rosário VE; Cravo P; et al. "Molecular characterisation of drug-resistant Plasmodium falciparum from Thailand.". Malaria Journal 1 (2002): 1-11. http://europepmc.org/abstract/med/12423551. 10.1186/1475-2875-1-12 "Abstracts of the 3rd European Congress on Tropical Medicine and International Health. September 8-11, 2002, Lisbon, Portugal.". Acta tropica (2002): Lopes, D.; Nogueira, F.; Gil, J.P.; Ferreira, C.; Do Rosário, V.E.; Cravo, P.. "pfcrt and pfmdr1 mutations and chloroquine resistance in Plasmodium falciparum from São Tomé and Príncipe, West Africa". Annals of Tropical Medicine and Parasitology 96 8 (2002): 831-834. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036976119&partnerID=MN8TOARS. 10.1179/000349802125002284 Nogueira, Fátima; Luisa Botelho, M.; Tenreiro, Rogério; Nogueira, F.; Botelho, M.L.; Tenreiro, R.. "Radioresistance studies in Methylobacterium spp.". Radiation Physics and Chemistry 52 1-6 (1998): 15-19. http://dx.doi.org/10.1016/s0969-806x(98)00024-3. 10.1016/s0969-806x(98)00024-3
Poster em conferência	Tiago Santos; Denise Maria Figueiredo Araujo Duarte; da Cruz Filho, Iranildo José; Maria do Carmo Alves de Lima; nogueira, fatima. Autor correspondente: nogueira, fatima. "Characterization and antiplasmodial activities new Thiazole-Thiosemicarbazone derivative". Trabalho apresentado em XIV Jornadas Científicas do IHMT, 2023. Santos, Tiago; Pintão, Ana; nogueira, fatima. "Antimalarial Activity of Tropaeolum majus L. Aqueous Extracts and Benzyl Isothiocyanate". Trabalho apresentado em 6th CiiEM International Congress, 2023.
Pré-impressão	Ana Maria Pintão; Tiago Alexandre Pena Santos; Fátima Nogueira. "Antimalarial Activity of Aqueous Extracts of Nasturtium (Tropaeolum majus L.) and Benzyl Isothiocyanate". 2024. https://doi.org/10.20944/preprints202403.0530.v1. 10.20944/preprints202403.0530.v1 Inês Morais; Soraia Rodrigues; Aida Mas; Serguei Escalon; Adalzira Borrego; Fatima Nogueira; Maria Lina Antunes. "Severe Malaria in Angola: Clinical Profile and Disease Outcome among Adults from a Low-Endemic Area". 2024. https://doi.org/10.20944/preprints202403.0541.v1. 10.20944/preprints202403.0541.v1 Ramos S; Ademolue TW; Jentho E; Wu Q; Guerra J; Martins R; Pires G; et al. "A HYPOMETABOLIC DEFENSE STRATEGY AGAINST PLASMODIUM INFECTION". 2021. http://europepmc.org/abstract/PPR/PPR393056. 10.1101/2021.09.08.459402
Resumo em conferência	Santos, Tiago; Isabela Sales; Ana M. Ferreira; Sintra, Tânia E.; Silvana Mattedi; Simão P. Pinho; João A.P. Coutinho; Mara G. Freire; nogueira, fatima. Autor correspondente: Santos, Tiago. "Artemisinin extracts with ionic liquids and salts hydrotropes as a Plasmodium falciparum antimalarial strategy". Trabalho apresentado em I Internacional Meeting Molecules 4Life, Vila Real, 2023. Publicado Elisabet Martí Coma-Cros; Christian Grandfils; Chantal Sevrin; Jos Paulusse; Naomi Hamelmann; Inga Siden-Kiamos; John Vontas; et al. "Development of Nanovectors for the Targeted Delivery in Anopheles Mosquitoes of Drugs against Plasmodium Parasites". 2019. 10.11159/nddte19.106 "Plenary Lectures". 2012. 10.1111/j.1742-4658.2010.08701.x "Abstracts from the 11th North American International Society for the Study of Xenobiotics (ISSX) Meeting. 27-31 October 2002, Orlando, Florida, USA.". 2002.

Propriedade Intelectual

Patente

Sousa, Emília; Long, Solida; Pinto, Madalena M. M.; Resende, Diana I. S. P.; Martins da Costa, Paulo; Freitas-silva, Joana; nogueira, fatima. 2020. "Sousa, M.E.L., S.; Pinto, M. M. d. M.; Resende, D. I. S. P.; Kijjoa, A.; Martins da Costa, P.; Freitas da Silva, J. M. M.; Nogueira, F. Pyrazino [1,2-b]quinazoline-3,6-diones derivatives, their production and uses thereof. International application number: PCT/IB2020/057831; International publication number: WO2021033159 A1; Filed August 20, 2020.". Portugal.
nogueira, fatima. 2019. "WO 2021/033159 A1 PYRAZINO [1,2-B]QUINAZOLINE-3,6-DIONES DERIVATIVES, THEIR PRODUCTION AND USES THEREOF".
Pendente
nogueira, fatima. 2019. "US20180186713 Antimalarial agent, methods and uses". Estados Unidos.
Concedida/Emitida
Leão, Pedro N.; Martins, Rosário; R. Martins; Rosário Martins; Vitor Vasconcelos; Margarida Costa; Valentina Domingues; nogueira, fatima. 2019. "ANTIMALARIAL AGENT, METHODS AND USES THEREOF". Estados Unidos.
Concedida/Emitida

Outros

Outra produção

Half- Sandwich cyclopentadienylruthenium(II) Complexes: A New Antimalarial Chemotype. 2020. Milheiro SA; Gonçalves J; Lopes R; Madureira M; Lobo L; Lopes A; Nogueira F; et al. http://europepmc.org/abstract/PPR/PPR153029.
10.26434/chemrxiv.12155178.v1
Structure of Hierridin C, Synthesis of Hierridins B and C, and Evidence for Prevalent Alkylresorcinol Biosynthesis in Picocyanobacteria. Small, single-celled planktonic cyanobacteria are ubiquitous in the world's oceans yet tend not to be perceived as secondary metabolite-rich organisms. Here we report the isolation and structure elucidation of hierridin C, a minor metabolite obtained from the cultured picocyanobacterium Cyanobium sp. LEGE 06113. We describe a simple, straightforward synthetic route to the scarcely produced hierrid. 2019. Costa, Margarida; Sampaio-Dias, Ivo E.; Castelo-Branco, Raquel; Scharfenstein, Hugo; Rezende de Castro, Roberta; Silva, Artur; Schneider, Maria Paula C.; et al. http://hdl.handle.net/10400.22/12978.
10.1021/acs.jnatprod.8b01038
Structure, synthesis of hierridin C and discovery of prevalent alkylresorcinol biosynthesis in picocyanobacteria. 2018. Costa, M.; Sampaio-Dias, I.E.; Castelo-Branco, R.; Scharfenstein, H.; Rezende de Castro, R.; Silva, A.; Schneider, M.P.C.; et al. http://www.scopus.com/inward/record.url?eid=2-s2.0-85095659313&partnerID=MN8TOARS.
10.26434/chemrxiv.7090526.v1
Immunological characterization of antibodies and antigens of Plasmodium falciparum in plasma samples obtained from individuals who previously stayed in malaria-endemic areas. 2015. D Portugal-Calisto; Teodósio R; f nogueira; Silva MS. https://novaresearch.unl.pt/en/publications/820558b0-aadb-41df-92b8-4c40e7a2e2fd.
Quantitative proteomics for the analysis of Plasmodium falciparum and its red blood cell host - a preliminary study. 2014. Patrícia Machado; Tiago R Vaz; f nogueira; João Rodrigues; Licínio Manco; Letícia Ribeiro; Ed Bergstrom; et al. https://novaresearch.unl.pt/en/publications/6ce3a4ea-127e-4b0b-9663-d686f1360621.
10.1186/1475-2875-13-S1-P74
Therapeutic efficacy of Coartem (R) for the treatment of uncomplicated malaria in Maputo, Mozambique. 2011. E Lobo; Luis Coelho; B de Sousa; N Fernandes; V do Rosario; f nogueira. https://novaresearch.unl.pt/en/publications/939d6e32-aa53-4624-9ff8-98d70246eb4b.
Size variations in a P. falciparu multidrug resistance protein (PfMRP) homologue and Coartem and artesunate plus amodiaquine clinical response [MIM-SD-175726]. 2005. S Dahlstrom; C Sisowath; f nogueira; A Martensson; A Bjorkman; José Pedro Gil. https://novaresearch.unl.pt/en/publications/239df65b-292c-4a89-b6b2-a7e5b9880827.

Atividades

Orientação

	Título / Tema Papel desempenhado	Curso (Tipo) Instituição / Organização
2022/01/26 - Atual	Clinical and parasitological response at day 7 after treatment of Plasmodium falciparum malaria with ACTs and their correlation with molecular markers of drug resistance in Banga, Angola Orientador de Mbueno Nzila	DOUTORAMENTO EM DOENÇAS TROPICAIS E SAÚDE GLOBAL/TROPICAL DISEASES AND GLOBAL HEALTH (Doutoramento) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal Universidade Agostinho Neto, Angola
2021/11/24 - Atual	Plasmodium falciparum redox system: the role of heterocycle thiosemicarbazones derivatives as potential regulators Orientador de Denise Maria Figueiredo Araújo Duarte	DOUTORAMENTO EM DOENÇAS TROPICAIS E SAÚDE GLOBAL/TROPICAL DISEASES AND GLOBAL HEALTH (Doutoramento) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal Universidade Federal de Pernambuco, Brasil
2020 - Atual	in vitro killing rates of anti-malarial compounds Orientador de Tiago Santos	Parasitologia Médica (Mestrado) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2020 - Atual	Custom dual-indexing and Illumina NGS to study drug resistant malaria Coorientador de Brigite Dias	Ciências Biomédicas (Mestrado) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2019/10/01 - Atual	Antimalarial Resistance in Mozambique: Characterization of molecular markers and assessment of susceptibility to Plasmodium falciparum Orientador de Clemente da Silva	Doutoramento em Ciências Biomédicas (Doutoramento) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2019/10 - Atual	Serum leptin and malnutrition in children with severe malaria in Mozambique Orientador	Doenças Tropicais e Saúde Global (Doutoramento) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2019/05 - Atual	Eficácia do tratamento da malária à base de artemisinina-lumefantrina e artesunato amodiaquina. Associação com os polimorfismos genéticos. Coorientador de Pedro Rafael Dimbu	CIÊNCIAS BIOMÉDICAS (Doutoramento) Universidade Agostinho Neto, Angola
2019 - Atual	Exploring bioorganometallic compounds with ferrocene moietis as antimalarials Orientador de Beatriz Duarte	Ciências Biomédicas (Mestrado) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2019 - Atual	Interruption of gametocyte to ookinete development Orientador de Jessica Fernandes	Ciências Biomédicas (Mestrado) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2020/09/01 - 2022/03/14	Interruption of gametocyte to ookinete development Orientador	MESTRADO EM CIÊNCIAS BIOMÉDICAS (Mestrado) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2020/09/01 - 2022/02/24	Ionic Liquids Applications as Antimalarial Drugs Orientador de Tiago Santos	MESTRADO EM PARASITOLOGIA MÉDICA /MASTER IN MEDICAL PARASITOLOGY (Mestrado) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2020/09/01 - 2021/12/14	Imported malaria in Portugal: a molecular perspective of CHLO and IHMT between 2014 and 2021 Orientador de Débora Serrano	MESTRADO EM SAÚDE TROPICAL /MASTER IN TROPICAL HEALTH (Mestrado) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2020/09/01 - 2021/09/24	Exploring bioorganometallic compounds with ferrocene moietis as antimalarials Orientador	MESTRADO EM CIÊNCIAS BIOMÉDICAS (Mestrado) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2019 - 2021	Identification of a potential malaria biomarker Coorientador de Raquel Cardoso	Ciências Biomédicas (Mestrado) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2016 - 2020/05/28	Characterization of Plasmodium falciparum antigens as candidates for the development of serological tests or candidates for vaccines for malaria. Coorientador de Yorleydy Ruiz Moreno	Ciências Biomédicas (Doutoramento) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2016 - 2019/05/14	In vitro characterization of the antimalarial activity and mode of action of new PDEs and DHODH inhibitors against Plasmodium falciparum Orientador de Jessy Silva	Parasitologia Médica (Mestrado) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2016 - 2019/01/11	Study of polymorphisms associated with P. falciparum resistance to ACTs in East Timor: Estudo da presença de polimorfismos associados à resistência de P. falciparum aos ACTs em Timor Leste Orientador de Patricia Duarte	Parasitologia Médica (Mestrado) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2015 - 2019	Study of antimalarial activity of new endoperoxides: potential parasite targets and mechanisms of action Orientador de Lis Lobo	Doutoramento em Ciências Biomédicas (Doutoramento) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2016/10 - 2018/12	To be or not to be transmited, what is in the question? Coorientador de Rafael Oliveira	Ciências Biomédicas (Mestrado) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2014/01 - 2018/12	Estudo da atividade anti-malárica e anti-toxoplásmica de endoperóxidos sintéticos: alvos parasitários e mecanismo de acção Supervisor in Portugal: Fátima Nogueira (IHMT/UNL, Lisbon, Portugal) Supervisor in Brazil: Valter Ferreira de Andrade Neto (UFRJ, Natal, Brazil) Orientador de Lis Tavares Coelho Lobo	Ciências Biomédicas (Doutoramento) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2016/10 - 2018/04	Antimalarial activity characterization of new quinazolinone derivatives Orientador de Vera Camões	Ciências Biomédicas (Mestrado) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2014/10 - 2017	Searching for SNPs in Plasmodium falciparum drug-resistance associated genes in East Timor Orientador de Joana Meda	Ciências Biomédicas (Mestrado) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2014/10 - 2017	New quinolones and phosphodiesterase inhibitors as antimalarials. Orientador de Cátia Nascimento	Saúde Tropical (Mestrado) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2012 - 2017	Estudo farmacodinâmico, em modelo murino-Plasmodium berghei, de compostos quimicamente definidos isolados de plantas usadas popularmente contra a malária e análise de genes de resistência aos antimaláricos em P. falciparum Coorientador de Valeska Santana de Sena Pereira	Universidade Federal do Rio Grande do Norte, Brasil
2016/05/16 - 2016/07/21	Training in Methods in malaria research. Sending Institution: Istituto Tecnico Superiore ITS Biomedicale em Mirandola, Italy. Orientador de Federico Gilioli	ERASMUS+ (Outra) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2014/10 - 2016/04	Towards the endoperoxides mechanism of action - assessment of deleterious effects on tolerant and susceptible parasites Orientador de Fernanda Murtinheira	Ciências Biomédicas (Mestrado) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2014/10 - 2016	Antimalarial activity mediated by efflux pumps; Actividade antimalárica mediada por bombas de efflux Orientador de Sílvia Pereira	Ciências Biomédicas (Mestrado) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2010 - 2015/07/31	Estudo da eficácia terapêutica in vivo das combinações terapêuticas baseadas nos derivados da artemisinina no tratamento de malária não complicada em Maputo Orientador de Elsa da Conceição Lobo	Ciências Biomédicas (Doutoramento) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2013/10 - 2015/07	Estudo de polimorfismos no gene que codifica a proteína kelch K13, um marcador de resistência às artemisininas, em Moçambique e Angola Coorientador de Carlos Gil Escobar	Saúde Tropical (Mestrado) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2013 - 2015	The antimalarials quest: Is ß- hematin a valid surrogate for native hemozoin? Coorientador de Simão Nunes Paula	Tecnologias Biomédicas (Mestrado) Universidade de Lisboa Instituto Superior Técnico, Portugal
2014 - 2014	Efflux pump-mediated activity of antimalarials” The student was trained in laboratorial techniques of Plasmodium falciparum in vitro culture, directed for the evaluation of antimalarial activity of candidate drugs. By the end of the training period, the trainee should be able to design, plan and execute independently laboratorial experiments aimed to characterize the parasite response to different efflux pumps inhibitors and their modulator effect on the antimalarials. Sending Institution: Jagiellonian University in Kraków, Poland Orientador de Karolina Chmielewska	ERASMUS (Outra) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2013/06 - 2013/09	Acquiring P. falciparum in-vitro culture skills for various purposes, especially in biological studies of the parasite and evaluation of the antimalarial activity in-vitro of new compounds. The student also implemented and optimized an assay based on the inhibition of the reaction GSH-haemin (fro drug screening) and tested sixteen new antimalarial candidate compounds. Sending institution: Universidad Complutense de Madrid. Madrid, Spain Orientador de Jaime Manzano	ERASMUS (Outra) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2010/10 - 2012	Estudo da eficácia terapêutica de novos trioxolanos em estirpes sensíveis e resistentes à artemisinina e artesunato Orientador de Lis Coelho	Parasitologia Médica (Mestrado) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2009 - 2011	Study of the gametocytocidal activity of primaquine derivatives; Estudo da actividade gametocitocida de derivados da primaquina Orientador de Elia Cabrita	Parasitologia Médica (Mestrado) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal

Organização de evento

	Nome do evento Tipo de evento (Tipo de participação)	Instituição / Organização
2019/01 - Atual	Malaria outbreak in Cape Verde on 2017: results presentation. at Instituto Nacional de Saúde Publica de Cabo Verde, Praia, Cape Verde. (2019/01) Encontro (Coorganizador)
2018/04 - Atual	Caracterização molecular de Plasmodium Falciparum em Cabo Verde (hands on workshop) Joint organization NOVA_IHMT and with Instituto Nacional de Saúde Publica de Cabo Verde at Praia, Cape Verde. (2018/04) Oficina (workshop) (Coorganizador)	Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2024/01/29 - 2034/02/08	Organization and teaching of the Antimalarial Susceptibility Assessment workshop (54 hours). Organized in collaboration with Prof. Lina Antunes the theoretical-practical workshop in collaboration with the Hospital Central do Lubango (HCL), which took place at HCL, Lubango, Huíla, Angola. (2024 - 2024) Oficina (workshop) (Coorganizador)	Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal Hospital Central do Lubango (HCL), Angola
2022/09/12 - 2022/09/23	Organization and teaching of the Molecular Biology Techniques workshop: molecular characterization of Plasmodium spp. (70h hours). Organized in collaboration with Prof. Lina Antunes the theoretical-practical workshop in collaboration with the Hospital Central do Lubango (HCL), which took place at HCL, Lubango, Huíla, Angola. (2022/09/12 - 2022/09/23) Oficina (workshop) (Coorganizador)	Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal Hospital Central do Lubango (HCL), Angola
2022/05/02 - 2022/05/20	Organization and teaching of the Molecular Biology In vitro and ex vivo techniques for evaluating susceptibility to antimalarials (30 hours). Organized in collaboration with Doctors Sónia Enosse and Paulo Arnaldo from the National Institute of Health (INS), Ministry of Health of Mozambique. 2022 (2022)	Instituto Nacional de Saúde de Moçambique/National Institute of Health (INS), Moçambique
2019/01/09 - 2019/01/10	organization and teaching of the "Sanger sequencing: sequence analysis" (16 hours). Organized in collaboration with Prof. Dr. Susana Campino (London School of Hygiene & Tropical Medicine, London, UK) and Master Silvania Leal from LEM, National Institute of Public Health of Cape Verde (INSP). It took place at INSP, Praia, Cape Verde. (2019) Oficina (workshop) (Coorganizador)	Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal Instituto Nacional de Saúde Pública de Cabo Verde , Cabo Verde
2018/04/16 - 2018/04/27	Organization and teaching of the Malaria Diagnosis course using molecular biology techniques. (93 hours). Organized in collaboration with Master Silvania Leal, LEM from the National Institute of Public Health of Cape Verde (INSP). It took place at INSP, Praia, Cape Verde. 16-27/04/2018. (2018 - 2018) Oficina (workshop) (Coorganizador)	Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal Instituto Nacional de Saúde Pública de Cabo Verde , Cabo Verde
2014/11/20 - 2014/11/21	Host – pathogen interaction. Towards a personalized medicine (2014/11/20 - 2014/11/21) Mesa-redonda (Coorganizador)	Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2009/01/18 - 2009/02/01	Scientific and pedagogic sessions as part of the CMDT LA PhD program in collaboration with Direcção Nacional de Saúde Pública de Angola. Organized by CMDT-LA/IHMT, Lisbon; Portugal and Direcção Nacional de Saúde Pública de Angola (Instituto Nacional de Saúde d Angola – INSA), Luanda; Angola (2009) Oficina (workshop) (Coorganizador)	Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2009/01/18 - 2009/02/01	Organization and teaching of the Workshop course Preparation of projects for doctoral candidacy. Organized in collaboration with Inv. Doctor Dinora Lopes (IHMT-NOVA) and Professor Doctor Filomeno Fortes (at the time of the National Directorate of Public Health of Angola). This training was carried out within the scope of the PROCAPS program, support from CMDT.LA for the doctoral program at IHMT-NOVA and the National Directorate of Public Health of Angola (started in 2006). It took place at the National Institute of Health of Angola – INSA, in Luanda (2009 - 2009)	Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal Instituto Nacional de Saúde de Angola (INSA), Angola
2006 - 2009	Organization of the PROCAPS program and teaching in some of the sessions. The program aimed to contribute to the training/qualification at PhD level of human resources in the health sector in Angola. 2006 – 2009. (2006 - 2009) Oficina (workshop) (Membro da Comissão Organizadora)	Instituto Nacional de Saúde Pública de Angola, Angola
2008/05/04 - 2008/05/11	Organization and teaching of the Malaria Diagnostic Techniques course. Within the scope of PROCAPS. Organized in collaboration with Inv. Doutora Dinora Lopes (IHMT-NOVA) and Professor Doutor Filomeno Fortes (at the time of the National Directorate of Public Health of Angola) in collaboration with the National Directorate of Public Health of Angola (Instituto Nacional de Saúde d Angola – INSA). This training was carried out within the scope of the PROCAPS program. At the National Institute of Health of Angola – INSA, in Luanda, Angola. (22h) (2008/05/04 - 2008/05/11) Oficina (workshop)	Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal Instituto Nacional de Saúde de Angola – INSA, Angola
2008/01/14 - 2008/01/24	Organization and teaching of the Advances in Cellular and Molecular Biology course (320h). Organized in collaboration with Profs. Doctors Maria do Socorro Pires e Cruz and Carlos Henrique Nery Costa Federal University of Piauí, within the scope of the Collaboration between CMDT.LA of IHMT-NOVA and the Doctoral Program of the Northeast Biotechnology Network (RENORBIO), Brazil. At the Animal Health Laboratory and Institute of Tropical Diseases Natan Portella. in Teresina, Brazil. 14 - 24/01/2008. (2008/01/14 - 2008/01/24) Oficina (workshop)	Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal Universidade Federal do Piauí, Brasil
2006/03/01 - 2006/03/31	Organization and teaching of the course on Assessment of in vitro susceptibility of P. falciparum to anti-malarials according to WHO MARKIII. Coordination of Prof. Doctor Luís Varandas, IHMT-NOVA) in collaboration with Dr. Luís Bernardino from the Hospital Pediátrico de Luanda David Bernardino (HPL). Within the scope of the REF project: FCG contract no. 65472 (referred to in 8.1.4). At HPL in Luanda, Angola. March 2006. Angola 2002 – 2006 (2006/03/01 - 2006/03/31) Oficina (workshop) (Coorganizador)	Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal Hospital Pediátrico de Luanda David Bernardino, Angola

Participação em evento

	Descrição da atividade Tipo de evento	Nome do evento Instituição / Organização
2016/05/10 - 2016/05/13	Tutor in the training course in the area of writing research proposals of the Special Program for Research and Training in Tropical Diseases of the World Health Organization (TDR), organized at IHMT-NOVA & TDR/WHO. 10-13/05/2016. Oficina (workshop)	Worshop on Proposal Writing Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal World Health Organization TDR, Suiça
2008/07/07 - 2008/07/11	Teaching of the Parasitology Workshop course. Coordination of Prof. Doctors Virgílio do Rosário (from the CMDT-LA of IHMT-NONA) and Professor Emília Noormahomed (from the Faculty of Medicine of the Eduardo Mondlane University; FM-UEM). It took place at FM-UEM, Maputo, Mozambique. (30 h) 07-11/07/2008. Oficina (workshop)	Workshop de Parasitologia Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal Faculty of Medicine of the Eduardo Mondlane University, Moçambique

Júri de grau académico

	Tema Tipo de participação	Nome do candidato (Tipo de grau) Instituição / Organização
2022/11/11	Targeting Plasmodium falciparum protein aggregation as a new antimalarial design strategy Presidente do júri	Ines Bouzon (Doutoramento) Universitat de Barcelona, Espanha
2020/12/04	Discovery of protein aggregation in Plasmodium parasites and development of a combinational antimalarial therapy at the nanoscale Vogal	ARNAU BIOSCA ROMANILLOS (Doutoramento) Universitat de Barcelona; Facultat de Farmacia i Ciències de l’Alimentació, Espanha
2020/12	Discovery of protein aggregation in Plasmodium parasites and development of a combinational antimalarial therapy at the nanoscale Vogal	Arnau Biosca Romanillos (Doutoramento) Universitat de Barcelona Facultat de Farmacia, Espanha
2019/04	TAXI – Targeting Antimalarial eX-star drugs for Intracellular delivery Arguente	Luisa Aguiar Tavares da Silva (Doutoramento) Universidade do Porto Faculdade de Ciências, Portugal
2016/03	Medicinal Chemistry Approaches to Malaria Drug Discovery Arguente	Sofia Alexandre Santos (Doutoramento) Universidade de Lisboa Faculdade de Farmácia, Portugal
2015/12	Exploration of sulfated polysaccharides as antimalarials and as targeting molecules for nanovector-mediated drug delivery to Plasmodium-infected cells Arguente principal	Joana Marques (Doutoramento) Universitat de Barcelona Facultat de Farmacia, Espanha
2015/02	Malária. Que factores determinam na industria farmacêutica, a dotação orçamental para a investigação de uma vacina Arguente principal	Ana Maria Pina Calado Guerra Ferreira (Mestrado) Universidade de Lisboa Instituto Superior de Ciências Sociais e Políticas, Portugal
2014/12	Evaluation of the involvement of efflux pumps in Schistosoma mansoni praziquantel drug resistance phenotype Arguente principal	Tiago Mendes (Mestrado) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2014/11	Characterization of a new malaria vaccine candidate against Plasmodium vivax using genetically modified rodent Plasmodium parasites Arguente principal	Miguel Filipe Duarte (Mestrado) Universidade de Lisboa Faculdade de Ciências, Portugal
2013/11	Genotipagem da mutação G829A no gene da piruvato cinase em indivíduos da Guiné-Bissau e sua associação com a malaria Arguente principal	Sara Cristina Inês Simões Pateira (Mestrado) Universidade de Lisboa Faculdade de Ciências, Portugal
2013/11	Gene expression during Plasmodium transmission Arguente principal	Neuza Arrimar Duarte (Mestrado) Universidade de Lisboa Faculdade de Ciências, Portugal
2012/12/13	Identification of drug resistance determinants in Plasmodium falciparum Arguente	João Marques (Mestrado) Universidade de Aveiro, Portugal
2012/03	Bioprospecting sulfated polysaccharides of seaweeds from the coast of Rio Grande do Norte: characterization of a heterofucan extracted from brown algae Sargassum filipendula that induces apoptosis in HeLa cells Arguente principal	Leandro Silva Costa (Doutoramento) Universidade do Estado do Rio Grande do Norte, Brasil
2012/03	Evaluation of the antimalarial activity of extracts and fractions obtained from algae Gracillaria birdiae and Spatoglossum schröederi Arguente principal	Gracielle Rodrigues Dantas (Mestrado) Universidade do Estado do Rio Grande do Norte, Brasil
2012/03	Avaliação da atividade antimalárica de extratos e frações obtidos das algas Gracillaria birdiae e Spatoglossum schröederi Arguente	Gracielle Rodrigues Dantas (Mestrado) Universidade Federal do Rio Grande do Norte, Brasil
2011/12	Pyruvate kinase deficiency protection against malaria: in vitro evaluation of 2,3-diphosphoglycerate toxicity and Plasmodium falciparum susceptibility Arguente principal	Ana Margarida Trancoso Gomes Rosa (Mestrado) Universidade de Lisboa Faculdade de Ciências, Portugal
2011/11/28	Análise serológica e imunoquímica de potenciais antigénios para a pesquisa de anticorpos anti-Plasmodium falciparum em pacientes com malária importada Arguente	Rita Costa (Mestrado) Universidade de Lisboa Faculdade de Ciências, Portugal
2010/07	Study of biological behavior in vitro and in vivo strains of Leishmania infantum Arguente principal	Andreia Filipa Ramos Ribeiro de Lemos Albuquerque (Outro) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Arbitragem científica em revista

	Nome da revista (ISSN)	Editora
2019 - Atual	Journal of Antimicrobial Chemotherapy (1460-2091)	Oxford University Press
2018 - Atual	ACS Infectious Diseases (2373-8227)	American Chemical Society
2017 - Atual	Antimicrobial Agents and Chemotherapy (1098-6596)	American Society for Microbiology
2017 - Atual	Nature (1476-4687)	Springer Nature
2017 - Atual	Parasitology International (1383-5769)	Elsevier
2016 - Atual	Experimental Parasitology (1090-2449)	Elsevier
2014 - Atual	British Biotechnology Journal (2231-2927)	Sciencedomain International
2014 - Atual	British Journal of Medicine and Medical Research (2231-0614)	Sciencedomain International
2014 - Atual	Journal of Advances in Medical and Pharmaceutical Sciences (2394-1111)	Sciencedomain International
2014 - Atual	The Lancet (1474-547X)	Elsevier
2014 - Atual	Asian Pacific Journal of Tropical Biomedicine (2221-1691)	Medknow Publications
2014 - Atual	plos one
2013 - Atual	African Journal of Pharmacy and Pharmacology (1996-0816)	Academic Journals
2011 - Atual	Malaria Journal (1475-2875)	Springer (Biomed Central Ltd.)
2008 - Atual	Transactions of the Royal Society of Tropical Medicine and Hygiene (1878-3503)	Oxford University Press

Consultoria / Parecer

	Descrição da atividade	Instituição / Organização
2022/09/23 - Atual	Organization and teaching of the workshop on Techniques for assessing susceptibility to anti-malarials (66 hours). Organized in collaboration with Prof. Lina Antunes the theoretical-practical workshop in collaboration with the Hospital Central do Lubango (HCL), which took place at HCL, Lubango, Huíla, Angola.	Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal Hospital Central do Lubango (HCL), Angola
2018 - Atual	MEDICAL ENTOMOLOGY LABORATORY (LEM) scientific consultant and technical-scientific support to the LEM team since 2018.	Instituto Nacional de Saúde Pública de Cabo Verde , Cabo Verde
2016/06/05 - 2016/06/10	Expert evaluator - H2020 Program Evaluation of the topics: INFRAIA-01-2016-2017 & INFRAIA -02-2017 (First stage)

Curso / Disciplina lecionado

	Disciplina	Curso (Tipo)	Instituição / Organização
2017 - Atual	Malaria: Plasmodium spp life cycle; drugs and resistance	Global Health and Tropical Medicine (Doutoramento)	Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2017 - Atual	UC coordinator -Thematic Rotation II	Doenças Tropicais e Saúde Global (Doutoramento)	Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2017 - Atual	UC Coordinator - Drug resistance genetics in parasitology	Parasitologia Médica (Mestrado)	Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2012 - Atual	UC Coordinator - Malária	Parasitologia Médica (Mestrado)	Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2012 - Atual	Malaria parasite life cycle and biology.	Ciências Biomédicas (Mestrado)	Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2012 - Atual	Malaria drug resistance mechanism and target	Ciências Biomédicas (Mestrado)	Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2012 - Atual	In vitro drug susceptibility assays (lectures and practical sessions)	Ciências Biomédicas (Mestrado)	Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2007 - Atual	Malaria drug resistance mechanism and targets	Ciências Biomédicas (Doutoramento)	Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2007 - Atual	Malaria parasite life cycle and biology	Parasitologia Médica (Mestrado integrado)	Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2007 - Atual	Malaria drug resistance mechanism and targets	Parasitologia Médica (Mestrado)	Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2007 - Atual	In vitro drug susceptibility assays (lectures and practical sessions)	Parasitologia Médica (Mestrado integrado)	Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2007 - Atual	Molecular Parasitology: gene expression (practical session)	Parasitologia Médica (Mestrado integrado)	Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2015 - 2015	Biotecnologia Aplicada às Doenças Infeciosas e Parasitárias	Programa de Pós-graduação em Medicina Tropical	Universidade do Estado do Amazonas, Brasil
2008 - 2015	Avanços em Biologia Celular e Molecular Biotecnologia Aplicada às Doenças Infeciosas e Parasitárias	Biotecnologia/RENORBIO (Doctor of Philosophy)	Universidade Federal do Piauí, Brasil
2009 - 2014	Molecular Microbiology and Parasitology	GABBA - Programa Graduado em Áreas da Biologia Básica e Aplicada (Doutoramento)	Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2007 - 2013	Parasitologia	Genética Molecular e Biomedicina (Mestrado)	Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2008 - 2012	TEACHING ACTIVITIES AT the PhD programme, Programa de Pós-Graduação em Biotecnologia/RENORBIO at Universidade Federal do Piauí, Teresina Brazil. Teaching the following subjects: Malaria parasite life cycle and biology (lectures) Malaria drug resistance mechanism and targets (lectures) In vitro drug susceptibility assays (lectures and practical sessions Concepts and application of molecular biology in medical parasitology	(Doutoramento)
2008 - 2012	Malaria parasite life cycle and biology of antimalarials drug resistance	Basic and Applied Biology GABBA (Doutoramento)	Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2009 - 2010	Parasitologia	Biologia Celular e Molecular (Mestrado)	Universidade de Coimbra, Portugal

Membro de comissão

	Descrição da atividade Tipo de participação	Instituição / Organização
2023/07/01 - Atual	Member of the ASM (American Society for Microbiology) Subcommittee for Career Development Grant for Postdoctoral Women (CDGPW). This subcommittee aims to promote professional development opportunities for postdoctoral women, including the Career Development Grant and Training for Postdoctoral Women. Membro	American Society for Microbiology, Estados Unidos

Outro júri / avaliação

	Descrição da atividade	Instituição / Organização
2011/04/01 - Atual	Referee/expert for the decision concerning admission of a thesis PhD thesis for evaluation (Artº 4.9 b) y 4.9 c) de la Normativa de desarrollo de los artículos 21 y 22 del R.D. 1393/2007)	Universidad Complutense de Madrid, Espanha

Tutoria

	Tópico	Nome do aluno
2018/09 - Atual	Epidemiology and health determinants: contributions to the elimination of malaria in Cape Verde	Júlio Monteiro Rodrigues
2016 - Atual	The role of a-gal (Gala1-3Galß1-4GlcNAc-R) on Plasmodium spp. sporozoites interaction with Anopheles spp. mosquito.	Helio Daniel Ribeiro Rocha
2012 - 2017/05	Development of an innovative real-time assay for antimalarial sensitivity testing and interrogation of novel compounds	Maria Rebelo
2010 - 2015	Canine leishmaniosis: the role of hepatocytes and Kupffer cells during Leishmania infantum infection	Maria Armanda Viana Rodrigues

Distinções

Prémio

2022	Prémio Professor Doutor Cruz Ferreira
2019	Prémio Professor Doutor João Fraga e Azevedo Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2006	Premio do Anuário do Hospital Dona Estefania –Medicine. Hospital Dona Estefânia, Portugal