MARIA DE FÁTIMA CARVALHO NOGUEIRA (7B1B-1ABB-1A16)

Curriculum Vitae

MARIA DE FÁTIMA CARVALHO NOGUEIRA

Fatima Nogueira is a researcher at Medical Parasitology UNIT, NOVA/IHMT. Graduated in Molecular Microbiology and Genetics from the University of Lisbon in 1996, she obtained a Master in Medical parasitology at NOVA/IHMT in 2001 and a PhD in Biomedical Sciences, specialty of Medical Parasitology in the same University in 2007. Her main research interests are the antimalarial drug resistance mechanisms and targets; Development of molecular tools for monitoring drug resistance in Plasmodium falciparum and P. vivax; Search for synthetic and natural compounds as potential new antimalarials. Currently IHMT-NOVA task coordinator of the projects: EuroNanoMed3-NANOpheles ref. 171129_ERA-Net_NANOpheles; PTDC/BTM-SAL/29786/2017; PTDC/MEDQUI/30021/2017; CIRCNA/BRB/0281/2019; and team member of PTDC/BIA-CEL/28456/2017. EU Expert EX2016D276705. Currently, is Associate Editor in the Anti-Infective Agents section of Frontiers in Drug Design and Discovery Over the years, and has been contributing with peer review for several Journals. She has co-authored over 70 papers in internationally indexed scientific journals, in the fields of malaria drug resistance and new antimalarials, with over 952 citations and an h-index of 19, according to the SCOPUS database assessed in 29th March 2023. She is a member of RSTMH (nº 0023123) and ASM (ID: 200343879). Holds 2 patents (https://novainnovation.unl.pt/2022/06/21/antimalarial-agent-methods-and-uses-thereof/; (https://novainnovation.unl.pt/2022/06/30/anti-infective-pyrazino-12-bquinazoline-36-diones-derivatives-and-their-production/). Regularly maintains field research collaboration&training activities in African with CPLP countries (São Tomé and Principe, Cape Verde, Angola and Mozambique), Cameroon and Senegal and in the Southeast Asia with Thailand and East Timor. Scientific advisory board member of the PhD program "Global Health and Infectious Diseases" at IHMT. Coordinates 4 curricular units (2 PhD and 2 MsC) and taches in 2 PhD and 5 MSc programs at IHMT-NOVA. Supervisor of 9 PhD students (5 ongoing, 4 completed) and 25 MSc students (21 completed, 4 ongoing).

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Identification

Personal identification

Full name: MARIA DE FÁTIMA CARVALHO NOGUEIRA
Gender: Female

Citation names

nogueira, fatima
nogueira F

Author identifiers

Ciência ID: 7B1B-1ABB-1A16
ORCID iD: 0000-0003-0313-0778
Researcher Id: I-2148-2012
Scopus Author Id: 7006748317

Telephones

Telephone

213652626 Ext.: 361 (Professional)

Knowledge fields

Medical and Health Sciences - Health Sciences - Parasitology

Languages

Language	Speaking	Reading	Writing	Listening	Peer-review
Portuguese (Mother tongue)
Spanish; Castilian	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)
English	Advanced (C1)	Proficiency (C2)	Advanced (C1)	Advanced (C1)	Advanced (C1)
French	Upper intermediate (B2)	Advanced (C1)	Intermediate (B1)	Advanced (C1)

Education

	Degree	Classification
2007 Concluded	DOUTORAMENTO (Doutoramento) Major in Medical Parasitology Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal "Estudos de biologia da multiresistência a antimaláricos em Plasmodium falciparum: transportadores ABC e genes de resposta ao stress oxidativo" (THESIS/DISSERTATION)	muito bom
2001 Concluded	Mestrado em Parasitologia Médica (Mestrado) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal	Muito Bom
1998 Concluded	Parasitologia Médica (Especialização pós-licenciatura) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal	16
1996 Concluded	licenciatura em Biologia Microbiana e Genética (Licenciatura) Universidade de Lisboa Faculdade de Ciências, Portugal	14
1986 Concluded	Dietética e Nutrição (Licenciatura) Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal	15

Affiliation

Science

	Category Host institution	Employer
2007/03/01 - Current	Auxiliary Researcher (Research)	Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
	Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal (...)
2007/05/01 - 2007/07/31	Visiting Researcher (Research)	Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
	Universidad Complutense de Madrid Facultad de Veterinaria, Spain
2001 - 2007	Research Assistant (Research)	Universidade Nova de Lisboa, Portugal
	Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal (...)
1989 - 2001	Research Trainee (Research)	Hospital de Santa Marta, Portugal
	Hospital de Santa Marta, Portugal
1997/01/01 - 1997/12/31	Visiting Researcher (Research)	Universidade de Lisboa Instituto Superior Tecnico Campus Tecnológico e Nuclear, Portugal
	Universidade de Lisboa Instituto Superior Tecnico Campus Tecnológico e Nuclear, Portugal

Other Careers

	Category Host institution	Employer
1989 - 1996	Assistente (Técnico Superior de Saúde - Nutrição)	Hospital de Santa Marta, Portugal

1989/08 - 1989/10	Assistente (Técnico Superior de Saúde - Nutrição)	Hospital CUF Tejo, Portugal

Projects

Contract

	Designation	Funders
2023/02/01 - Current	A non-canonical protective response against malaria , Refª 2022.02426.PTDC 2022.02426.PTDC Researcher Universidade Nova de Lisboa Saúde Global e Medicina Tropical, Portugal The Johns Hopkins Hospital, United States	Fundação para a Ciência e a Tecnologia Ongoing
2020 - Current	PYRAZINO [1,2-B]QUINAZOLINE-3,6-DIONES DERIVATIVES, THEIR PRODUCTION AND USES THEREOF REF: 46871	Horizon 2020
2019 - Current	PYRAZINO [1,2-B]QUINAZOLINE-3,6-DIONES DERIVATIVES, THEIR PRODUCTION AND USES THEREOF REF:46871 Co-Principal Investigator (Co-PI) Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal	European Union Ongoing
2018/10/01 - Current	When the host cell is not so cosy anymore? A drop off in energy or an increase in toxicity? PTDC/BIA-CEL/28456/2017 Researcher Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2017/06/01 - Current	VIASEF - In VIvo Arthropod SEcurity Facility FCT/P2020, FEDER. Project nº 22077 Researcher	Fundação para a Ciência e a Tecnologia
1999/01/01 - Current	T-Cell response in pathogenesis of malaria infection POCTI/36369/MGI/1999 MsC student Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal Instituto Gulbenkian de Ciência, Portugal Institut Pasteur, France	Fundação para a Ciência e a Tecnologia Concluded
2020/03/01 - 2023/12/31	AMAZING – AMAZonian snake toxins: creatING value from bioresources CIRCNA/BRB/0281/2019 Researcher Universidade Nova de Lisboa Saúde Global e Medicina Tropical, Portugal REQUIMTE LAQV Porto, Portugal Universidade do Porto, Portugal Instituto de Medicina Molecular João Lobo Antunes, Portugal Universidad Regional Amazónica IKIAM, Ecuador Universidad Tecnológica Indoamérica - Quito, Ecuador Universidade Estadual de Campinas, Brazil	Fundação para a Ciência e a Tecnologia Ongoing
2018/10/04 - 2022/01/03	A small couple against the big three PTDC/BTM-SAL/29786/2017 Researcher Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal REQUIMTE LAQV Porto, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2018/10/01 - 2021/09/30	A multitarget strategy to hit all stages of the Plasmodium life-cycle PTDC/MED-QUI/30021/2017 Researcher Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal Universidade de Lisboa Faculdade de Farmácia, Portugal Instituto de Medicina Molecular João Lobo Antunes, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2018/03/01 - 2021/02/28	Development of nanovectors for the targeted delivery in Anopheles mosquitoes of agents blocking transmission of Plasmodium parasites 171129_ERA-Net_NANOpheles Researcher Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal Instituto de Salud Global Barcelona, Spain Universiteit Twente, Netherlands Université de Liège, Belgium	European Regional Development Fund Concluded
2011/04/01 - 2014/09/30	Disorders on the Glycolytic and Pentose Phosphate Pathways of the Red Blood Cell - how do they affect Plasmodium infection? PTDC/SAU-MET/110323/2009 Researcher Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2011/03/01 - 2014/08/31	TARGETING HEMOZOIN CRYSTAL STRUCTURE: A RATIONAL APPROACH TO THE DESIGN OF NOVEL ANTIMALARIALS PTDC/SAU-FAR/114864/2009 Researcher Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal Universidade de Lisboa Faculdade de Farmácia, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2010/01/01 - 2013/12/31	Proteómica y quimiogenómica de inhibidores de proteasas de origen natural con potencial terapéutico en malaria UNESCO 230221, 2415, 230227, 230222, 239001, 320719 Researcher Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal Universidad Nacional de la Plata Facultad de Ciencias Exactas, Argentina	Ciencia y Tecnología para el Desarrollo Concluded
2011/01/01 - 2012/12/30	Caracterização bioquímica e envolvimento farmacológico de metaloproteinases isoladas do parasita Trypanosoma brucei FCT-CAPES 2011-2012 Researcher Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal Universidade Federal do Rio Grande do Norte Centro de Biociências, Brazil	Fundação para a Ciência e a Tecnologia Concluded
2009/01/01 - 2012/04/30	Recycling antimalarials: rational design of novel 8-aminoquinoline analogues with gametocytocidal and blood-schizontocidal activity PTDC/QUI/65142/2006 Researcher Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal Universidade do Porto Faculdade de Ciências, Portugal Universidade de Lisboa Faculdade de Farmácia, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2011 - 2012	Defining the role and extent of protein glycosylation in the malaria causing parasite Plasmodium falciparum Projectos CMDT /IHMT Researcher Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal Centro de Investigación en Salud Internacional de Barcelona, Spain Instituto de Salud Global Barcelona, Spain	Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical Concluded
2011 - 2012	Defining the role and extent of protein glycosylation in the malaria causing parasite Plasmodium falciparum Projectos CMDT /IHMT	Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical
2003/01/01 - 2006/06/30	Development of a malaria resistance DNA chip as a public health tool for the management of Plasmodium falciparum malaria drug resistance QLK2-CT-2002-01503 PhD Student Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal Schweizerisches Tropen- und Public Health-Institut, Switzerland Institut Pasteur, France Institut Pasteur de la Guyane, French Guiana Institut Pasteur de Madagascar, Madagascar Institut Pasteur du Cambodge, Cambodia Institut Pasteur de Dakar, Senegal	European Union Concluded
2002/04/01 - 2005/04/01	Studies on the human host pharmacogenetics and the use of antimalarials POCTI/ESP/39580/2001 PhD Student Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2002/03/31 - 2005/03/31	A new approach to antimalarial therapy. Novel chemical delivery systems for primaquine and amodiaquine POCTI/FCB/39218/2001 PhD Student Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2004/08/04 - 2005/02/04	Can Malarone® be recommended as antimalarial prophylaxis for PALOP cuntries? Search for mutations in the Plasmodium falciparum cytochrome b gene associated with resistance to Malarone® in Angola, Mozambique and S. Tomé and Príncipe FCG Researcher Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal	Fundação Calouste Gulbenkian Concluded
2002/02 - 2005/02	Studies on the genetics of drug resistance in malaria POCTI/ESP/42666/2001 PhD Student	Fundação para a Ciência e a Tecnologia
2002/01/01 - 2004/01/01	Proteases of malaria parasites targets for chemoterapy POCTI/ESP/42233/2001 PhD Student Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal	Fundação para a Ciência e a Tecnologia Concluded

Outputs

Publications

Journal article

CLEMENTE DA SILVA; Daniela Matias; Brigite Dias; Beatriz Cancio; Miguel Silva; Ruben Viegas; Nordino Chivale; et al. "Anti-malarial resistance in Mozambique: Absence of Plasmodium falciparum Kelch 13 (K13) propeller domain polymorphisms associated with resistance to artemisinins". Malaria Journal 22 1 (2023): http://dx.doi.org/10.1186/s12936-023-04589-0.
10.1186/s12936-023-04589-0
Natali de França Nibbering Santos; Natanael da Silva Bezerra Junior; Jamerson Ferreira de Oliveira; Denise Maria Figueiredo Araújo Duarte; José Cleberson dos Santos Soares; Diego Santa Clara Marques; Aline Caroline da Silva Santos; et al. "Synthesis, characterization, antioxidant and antiparasitic activities new naphthyl-thiazole derivatives". Experimental Parasitology 248 (2023): 108498-108498. http://dx.doi.org/10.1016/j.exppara.2023.108498.
10.1016/j.exppara.2023.108498
José Rafael Almeida; Ana Gomes; Bruno Mendes; Luísa Aguiar; Mariana Ferreira; Mariana Borges Costa Brioschi; Denise Duarte; et al. "Unlocking the potential of snake venom-based molecules against the malaria, Chagas disease, and leishmaniasis triad". International Journal of Biological Macromolecules (2023): 124745-124745. http://dx.doi.org/10.1016/j.ijbiomac.2023.124745.
10.1016/j.ijbiomac.2023.124745
Iranildo José da Cruz Filho; Denise Maria Figueiredo Araujo Duarte; Douglas da Conceição Alves de Lima; Diego Santa Clara Marques; Fábio André Brayner dos Santos; Luiz Carlos Alves; André de Lima Aires; Fátima Nogueira; Maria do Carmo Alves de Lima. "In vitro evaluation of alkaline lignins as antiparasitic agents and their use as an excipient in the release of benznidazole". International Journal of Biological Macromolecules 231 (2023): 123339-123339. http://dx.doi.org/10.1016/j.ijbiomac.2023.123339.
10.1016/j.ijbiomac.2023.123339
Araújo, Denise Maria Figueiredo; da Cruz Filho, Iranildo José; Santos, Tiago; Pereira, Daniel Tarciso Martins; Marques, Diego Santa Clara; da Conceição Alves de Lima, Alice; de Aquino, Thiago Mendonça; et al. "Biological activities and physicochemical characterization of alkaline lignins obtained from branches and leaves of Buchenavia viridiflora with potential pharmaceutical and biomedical applications". International Journal of Biological Macromolecules 219 (2022): 224-245. http://dx.doi.org/10.1016/j.ijbiomac.2022.07.225.
Published • 10.1016/j.ijbiomac.2022.07.225
Ramos S; Ademolue TW; Jentho E; Wu Q; Guerra J; Martins R; Pires G; et al. "A hypometabolic defense strategy against malaria.". Cell metabolism (2022): http://europepmc.org/abstract/med/35841892.
10.1016/j.cmet.2022.06.011
Morais I; Medeiros MM; Carvalho M; Morello J; Teixeira SM; Maciel S; Nhantumbo J; et al. "Synthetic Red Blood Cell-Specific Glycolytic Intermediate 2,3-Diphosphoglycerate (2,3-DPG) Inhibits Plasmodium falciparum Development In Vitro.". Frontiers in cellular and infection microbiology (2022): http://europepmc.org/abstract/med/35372095.
10.3389/fcimb.2022.840968
Rafael F. A. Gomes; Joao M. J. M. Ravasco; Késsia H. S. Andrade; Jaime A. S. Coelho; Rui Moreira; Rafael Oliveira; Fátima Nogueira; Carlos A. M. Afonso. "Tandem Thio-Michael Addition/Remote Lactone Activation of 5-Hydroxymethylfurfural-Derived d-Lactone-Fused Cyclopentenones". ChemSusChem (2022): https://doi.org/10.1002/cssc.202102204.
10.1002/cssc.202102204
"Indole-Containing Pyrazino[2,1-b]quinazoline-3,6-diones Active against Plasmodium and Trypanosomatids". ACS Medicinal Chemistry Letters (2022): http://dx.doi.org/10.1021/acsmedchemlett.1c00589.
10.1021/acsmedchemlett.1c00589
Silva AT; Oliveira IS; Gomes J; Aguiar L; Fontinha D; Duarte D; Nogueira F; et al. "Drug-Derived Surface-Active Ionic Liquids: A Cost-Effective Way To Expressively Increase the Blood-Stage Antimalarial Activity of Primaquine.". ChemMedChem (2021): http://europepmc.org/abstract/med/34882979.
10.1002/cmdc.202100650
Debora Serrano; Ana Santos-Reis; Clemente Silva; Ana Dias; Brigite Dias; Cristina Toscano; Cláudia Conceição; Teresa Baptista-Fernandes; Fatima Nogueira. "Imported Malaria in Portugal: Prevalence of Polymorphisms in the Anti-Malarial Drug Resistance Genes pfmdr1 and pfk13". Microorganisms (2021): https://doi.org/10.3390/microorganisms9102045.
10.3390/microorganisms9102045
Silva-Pinto A; Domingos J; Cardoso M; Reis A; Benavente ED; Caldas JP; Conceição C; et al. "Artemether-lumefantrine treatment failure of uncomplicated Plasmodium falciparum malaria in travellers coming from Angola and Mozambique.". International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases (2021): http://europepmc.org/abstract/med/34242769.
10.1016/j.ijid.2021.07.008
Ambroise Ahouidi; Luzia Helena Carvalho; Rafael Oliveira; Lis Lobo; Cyrille Diedhiou; Souleymane Mboup; Fatima Nogueira. "Prevalence of pfk13 and pfmdr1 polymorphisms in Bounkiling, Southern Senegal". PLOS ONE (2021): https://doi.org/10.1371/journal.pone.0249357.
10.1371/journal.pone.0249357
Da Veiga Leal S; Ward D; Campino S; Benavente ED; Ibrahim A; Claret T; Isaías V; et al. "Drug resistance profile and clonality of Plasmodium falciparum parasites in Cape Verde: the 2017 malaria outbreak.". Malaria journal (2021): http://europepmc.org/abstract/med/33789667.
10.1186/s12936-021-03708-z
Sofia A. Milheiro; Joana Gonçalves; Ricardo M. R. M. Lopes; Margarida Madureira; Lis Lobo; Andreia Lopes; Fátima Nogueira; et al. "Half-Sandwich Cyclopentadienylruthenium(II) Complexes: A New Antimalarial Chemotype". Inorganic Chemistry 59 17 (2020): 12722-12732. https://doi.org/10.1021/acs.inorgchem.0c01795.
10.1021/acs.inorgchem.0c01795
Elena Lantero; Jessica Fernandes; Carlos Raúl Aláez-Versón; Joana Gomes; Henrique Silveira; Fatima Nogueira; Xavier Fernàndez-Busquets. "Heparin Administered to Anopheles in Membrane Feeding Assays Blocks Plasmodium Development in the Mosquito". Biomolecules (2020): https://doi.org/10.3390/biom10081136.
10.3390/biom10081136
Gomes PATM; Cardoso MVO; Santos IR; Sousa F; Conceição J; Silva V; Duarte D; et al. "Dual Parasiticidal Activities of New Phthalimides: Synthesis and Biological Profile against Trypanosoma cruzi and Plasmodium falciparum.". ChemMedChem (2020): http://europepmc.org/abstract/med/32813331.
10.1002/cmdc.202000331
Ana Teresa Silva; Lis Lobo; Isabel S. Oliveira; Joana Gomes; Cátia Teixeira; Fátima Nogueira; Eduardo F. Marques; Ricardo Ferraz; Paula Gomes. "Building on Surface-Active Ionic Liquids for the Rescuing of the Antimalarial Drug Chloroquine". International Journal of Molecular Sciences 21 15 (2020): 5334-5334. https://doi.org/10.3390/ijms21155334.
10.3390/ijms21155334
Valério, Gabriel N.; Gutiérrez-Merino, Carlos; Nogueira, Fatima; Moura, Isabel; Moura, José J.G.; Samhan-Arias, Alejandro K.. "Human erythrocytes exposure to juglone leads to an increase of superoxide anion production associated with cytochrome b5 reductase uncoupling". Biochimica et Biophysica Acta (BBA) - Bioenergetics 1861 2 (2020): 148134. http://dx.doi.org/10.1016/j.bbabio.2019.148134.
Published • 10.1016/j.bbabio.2019.148134
Luísa Aguiar; Arnau Biosca; Elena Lantero; Jiri Gut; Nuno Vale; Philip J. Rosenthal; Fátima Nogueira; et al. "Coupling the Antimalarial Cell Penetrating Peptide TP10 to Classical Antimalarial Drugs Primaquine and Chloroquine Produces Strongly Hemolytic Conjugates". Molecules 24 24 (2019): 4559-4559. https://doi.org/10.3390/molecules24244559.
10.3390/molecules24244559
Ruiz Moreno, Yorleydy; Donato, Silvia Tavares; Nogueira, Fátima; Sousa Silva, Marcelo. "Comparative Analysis of the Serological Reactivity of Individuals with Clinical History of Malaria using Two Different ELISA Tests". Diagnostics 9 4 (2019): 168. http://dx.doi.org/10.3390/diagnostics9040168.
Published • 10.3390/diagnostics9040168
Lobo, Lis; Cabral, Lília I. L.; Sena, Maria Inês; Guerreiro, Bruno; Rodrigues, António Sebastião; de Andrade-Neto, Valter Ferreira; Cristiano, Maria L. S.; Nogueira, Fatima. "New endoperoxides highly active in vivo and in vitro against artemisinin-resistant Plasmodium falciparum". Malaria Journal 17 1 (2018): http://dx.doi.org/10.1186/s12936-018-2281-x.
10.1186/s12936-018-2281-x
Domingos J; Casimiro A; Portugal-Calisto D; Varandas L; Nogueira F; Silva MS. "Clinical, laboratorial and immunological aspects of severe malaria in children from Guinea-Bissau.". Acta tropica (2018): http://europepmc.org/abstract/med/29684356.
10.1016/j.actatropica.2018.04.020
De Sena Pereira, V.S.; Da Silva Emery, F.; Lobo, L.; Nogueira, F.; Oliveira, J.I.N.; Fulco, U.L.; Albuquerque, E.L.; Katzin, A.M.; De Andrade-Neto, V.F.. "In vitro antiplasmodial activity, pharmacokinetic profiles and interference in isoprenoid pathway of 2-aniline-3-hydroxy-1.4-naphthoquinone derivatives". Malaria Journal 17 1 (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85058884809&partnerID=MN8TOARS.
10.1186/s12936-018-2615-8
Horta, P.; Henriques, M.S.C.; Brás, E.M.; Murtinheira, F.; Nogueira, F.; O'Neill, P.M.; Paixaõ, J.A.; et al. "On the ordeal of quinolone preparation via cyclisation of aryl-enamines; Synthesis and structure of ethyl 6-methyl-7-iodo-4-(3-iodo-4-methylphenoxy)-quinoline-3-carboxylate". Pure and Applied Chemistry 89 6 (2017): 765-780. http://www.scopus.com/inward/record.url?eid=2-s2.0-85020515500&partnerID=MN8TOARS.
10.1515/pac-2016-1119
Lobo L; Sousa Bd; Cabral L; Cristiano ML; Nogueira F; Lobo, L.; de Sousa, B.; et al. "Highly active ozonides selected against drug resistant malaria.". Memorias do Instituto Oswaldo Cruz 111 7 (2016): 450-453. http://europepmc.org/abstract/med/27276364.
10.1590/0074-02760160077
nogueira, fatima. "Whole-Cell SYBR Green I Assay for Antimalarial Activity Assessment". (2016): https://www.jscimedcentral.com/MedicalMicrobiology/medicalmicrobiology-2-1010.pdf.
Ferraz, R.; Noronha, J.; Murtinheira, F.; Nogueira, F.; Machado, M.; Prudêncio, M.; Parapini, S.; et al. "Primaquine-based ionic liquids as a novel class of antimalarial hits". RSC Advances 6 61 (2016): 56134-56138. http://www.scopus.com/inward/record.url?eid=2-s2.0-84975078549&partnerID=MN8TOARS.
10.1039/c6ra10759a
M Machado; F Murtinheira; E Lobo; f nogueira. "Whole-cell SYBR Green I assay for antimalarial activity assessment". Annals of Clinical and Medical Microbiology 2 (2016): https://novaresearch.unl.pt/en/publications/bf8be0c0-a719-4d50-8b20-d8579f2e3b2b.
Figueiras M; Coelho L; Wicht KJ; Santos SA; Lavrado J; Gut J; Rosenthal PJ; et al. "N10,N11-di-alkylamine indolo[3,2-b]quinolines as hemozoin inhibitors: Design, synthesis and antiplasmodial activity.". (2015): http://europepmc.org/abstract/med/25725608.
10.1016/j.bmc.2015.02.007
Faísca Phillips AM; Nogueira F; Murtinheira F; Barros MT. "Synthesis and antimalarial evaluation of prodrugs of novel fosmidomycin analogues.". (2015): http://europepmc.org/abstract/med/25881827.
10.1016/j.bmcl.2015.03.077
Escobar C; Pateira S; Lobo E; Lobo L; Teodosio R; Dias F; Fernandes N; et al. "Polymorphisms in Plasmodium falciparum K13-Propeller in Angola and Mozambique after the Introduction of the ACTs.". (2015): http://europepmc.org/abstract/med/25789669.
10.1371/journal.pone.0119215
Santos, S.A.; Lukens, A.K.; Coelho, L.; Nogueira, F.; Wirth, D.F.; Mazitschek, R.; Moreira, R.; et al. "Exploring the 3-piperidin-4-yl-1H-indole scaffold as a novel antimalarial chemotype". European Journal of Medicinal Chemistry 102 (2015): 320-333. http://www.scopus.com/inward/record.url?eid=2-s2.0-84939606151&partnerID=MN8TOARS.
10.1016/j.ejmech.2015.07.047
Gomes, A.; Machado, M.; Lobo, L.; Nogueira, F.; Prudêncio, M.; Teixeira, C.; Gomes, P.; et al. "N-Cinnamoylation of Antimalarial Classics: Effects of Using Acyl Groups Other than Cinnamoyl toward Dual-Stage Antimalarials". ChemMedChem 10 8 (2015): 1344-1349. http://www.scopus.com/inward/record.url?eid=2-s2.0-84937978987&partnerID=MN8TOARS.
10.1002/cmdc.201500164
Horta, P.; Kus, N.; Henriques, M.S.C.; Paixão, J.A.; Coelho, L.; Nogueira, F.; O'Neill, P.M.; et al. "Quinolone-Hydroxyquinoline Tautomerism in Quinolone 3-Esters. Preserving the 4-Oxoquinoline Structure To Retain Antimalarial Activity". Journal of Organic Chemistry 80 24 (2015): 12244-12257. http://www.scopus.com/inward/record.url?eid=2-s2.0-84952802726&partnerID=MN8TOARS.
10.1021/acs.joc.5b02169
Portugal-Calisto, D.; Teodosio, R.; Nogueira, F.; Silva, M. Sousa. "Immunological characterization of antibodies and antigens of Plasmodium falciparum in plasma samples obtained from individuals who previously stayed in malaria-endemic areas". Tropical Medicine & International Health (2015): https://publons.com/publon/13993993/.
Carrasco MP; Newton AS; Gonçalves L; Góis A; Machado M; Gut J; Nogueira F; et al. "Probing the aurone scaffold against Plasmodium falciparum: design, synthesis and antimalarial activity.". (2014): http://europepmc.org/abstract/med/24813880.
10.1016/j.ejmech.2014.04.076
Paulo A; Figueiras M; Machado M; Charneira C; Lavrado J; Santos SA; Lopes D; et al. "Bis-alkylamine Indolo[3,2-b]quinolines as hemozoin ligands: implications for antimalarial cytostatic and cytocidal activities.". (2014): http://europepmc.org/abstract/med/24673163.
10.1021/jm500075d
Miranda D; Capela R; Albuquerque IS; Meireles P; Paiva I; Nogueira F; Amewu R; et al. "Novel endoperoxide-based transmission-blocking antimalarials with liver- and blood-schizontocidal activities.". (2014): http://europepmc.org/abstract/med/24900781.
10.1021/ml4002985
Gomes A; Pérez B; Albuquerque I; Machado M; Prudêncio M; Nogueira F; Teixeira C; Gomes P. "N-cinnamoylation of antimalarial classics: quinacrine analogues with decreased toxicity and dual-stage activity.". (2014): http://europepmc.org/abstract/med/24474655.
10.1002/cmdc.201300459
Marques MM; Costa MR; Santana Filho FS; Vieira JL; Nascimento MT; Brasil LW; Nogueira F; et al. "Plasmodium vivax Chloroquine Resistance and Anemia in the Western Brazilian Amazon.". (2014): http://europepmc.org/abstract/med/24165179.
10.1128/AAC.02279-12
Lobo E; de Sousa B; Rosa S; Figueiredo P; Lobo L; Pateira S; Fernandes N; Nogueira F. "Prevalence of pfmdr1 alleles associated with artemether-lumefantrine tolerance/resistance in Maputo before and after the implementation of artemisinin-based combination therapy.". (2014): http://europepmc.org/abstract/med/25098280.
10.1186/1475-2875-13-300
Machado P; Vaz TR; Nogueira F; Rodrigues J; Manco L; Ribeiro L; Bergstrom E; et al. "Quantitative proteomics for the analysis of Plasmodium falciparum and its red blood cell host - a preliminary study.". (2014): http://europepmc.org/abstract/PMC/PMC4179439.
Arez, Ana Paula; Henrique Silveira; f nogueira. "Mais de meio século da investigação de malária no IHMT". Anais do Instituto de Higiene e Medicina Tropical 13 (2014): 7-17. https://novaresearch.unl.pt/en/publications/d390f3d3-677a-4ba7-9842-cc05fe600ef0.
https://doi.org/10.25761/anaisihmt.165
P. A. Carvalho; L. Coelho; R. C. Martins; f nogueira. "Differences between synthetic ß-haematin and native hemozoin crystals.". Microscopy and Microanalysis 19 Suppl. 4 (2013): 49-50. https://novaresearch.unl.pt/en/publications/dd50f455-6af8-4ebc-8395-5cce75e2a756.
Costa, R.M.; Nogueira, F.; De Sousa, K.P.; Vitorino, R.; Silva, M.S.; Costa RM; Nogueira F; et al. "Immunoproteomic analysis of Plasmodium falciparum antigens using sera from patients with clinical history of imported malaria". Malaria Journal 12 1 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84875026266&partnerID=MN8TOARS.
10.1186/1475-2875-12-100
Chehuan, Y.F.; Costa, M.R.; Costa, J.S.; Alecrim, M.G.; Nogueira, F.; Silveira, H.; Brasil, L.W.; et al. "In vitro chloroquine resistance for Plasmodium vivax isolates from the Western Brazilian Amazon". Malaria Journal 12 1 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84879835113&partnerID=MN8TOARS.
10.1186/1475-2875-12-226
Matos, J.; Da Cruz, F.P.; Cabrita, É.; Gut, J.; Nogueira, F.; Do Rosário, V.E.; Moreira, R.; et al. "Novel potent metallocenes against liver stage malaria". Antimicrobial Agents and Chemotherapy 56 3 (2012): 1564-1570. http://www.scopus.com/inward/record.url?eid=2-s2.0-84857165822&partnerID=MN8TOARS.
10.1128/AAC.05345-11
Goncalves, E.; Marques, C.; Nogueira, F.; Rosario, V.; Ribeiro, V.. "Regulation of drugs metabolizing enzymes and transporters in mouse liber by primaquine". The FEBS Journal (2012): https://publons.com/publon/13993948/.
Albuquerque, D.; Manco, L.; Loua, K.M.; Arez, A.P.; De Jesus Trovoada, M.; Relvas, L.; Millimono, T.S.; et al. "SLC40A1 Q248H allele frequencies and associated SLC40A1 haplotypes in three West African population samples". Annals of Human Biology 38 3 (2011): 378-381. http://www.scopus.com/inward/record.url?eid=2-s2.0-79953084701&partnerID=MN8TOARS.
10.3109/03014460.2010.541496
"Therapeutic efficacy of Coartem (R) for the treatment of uncomplicated malaria in Maputo, Mozambique". Tropical Medicine & International Health (2011): https://publons.com/publon/7749080/.
Nogueira, F.; Diez, A.; Radfar, A.; Pérez-Benavente, S.; Rosario, V.E.d.; Puyet, A.; Bautista, J.M.. "Early transcriptional response to chloroquine of the Plasmodium falciparum antioxidant defence in sensitive and resistant clones". Acta Tropica 114 2 (2010): 109-115. http://www.scopus.com/inward/record.url?eid=2-s2.0-77649185865&partnerID=MN8TOARS.
10.1016/j.actatropica.2010.01.013
Manco, L.; Machado, P.; Lopes, D.; Nogueira, F.; Do Rosário, V.E.; Alonso, P.L.; Varandas, L.; et al. "Analysis of TPI gene promoter variation in three sub-Saharan Africa population samples". American Journal of Human Biology 21 1 (2009): 118-120. http://www.scopus.com/inward/record.url?eid=2-s2.0-59549103434&partnerID=MN8TOARS.
10.1002/ajhb.20819
Vale, N.; Prudêncio, M.; Marques, C.A.; Collins, M.S.; Gut, J.; Nogueira, F.; Matos, J.; et al. "Imidazoquines as antimalarial and antipneumocystis agents". Journal of Medicinal Chemistry 52 23 (2009): 7800-7807. http://www.scopus.com/inward/record.url?eid=2-s2.0-72249095184&partnerID=MN8TOARS.
10.1021/jm900738c
Vale, N.; Nogueira, F.; do Rosário, V.E.; Gomes, P.; Moreira, R.. "Primaquine dipeptide derivatives bearing an imidazolidin-4-one moiety at the N-terminus as potential antimalarial prodrugs". European Journal of Medicinal Chemistry 44 6 (2009): 2506-2516. http://www.scopus.com/inward/record.url?eid=2-s2.0-64249118390&partnerID=MN8TOARS.
10.1016/j.ejmech.2009.01.018
f nogueira; Dinora Lopes; Ana Catarina Alves; Virgilio Estólio do Rosário. "Plasmodium falciparum multidrug resistance protein (MRP) gene expression under chloroquine and mefloquine challenge". Journal of Cell and Animal Biology 2 1 (2008): 010-020. https://novaresearch.unl.pt/en/publications/d5c07332-2a95-44f8-b159-fe09025d6efa.
Vale, N.; Matos, J.; Gut, J.; Nogueira, F.; do Rosário, V.; Rosenthal, P.J.; Moreira, R.; Gomes, P.. "Imidazolidin-4-one peptidomimetic derivatives of primaquine: Synthesis and antimalarial activity". Bioorganic and Medicinal Chemistry Letters 18 14 (2008): 4150-4153. http://www.scopus.com/inward/record.url?eid=2-s2.0-47149096687&partnerID=MN8TOARS.
10.1016/j.bmcl.2008.05.076
Figueiredo, P.; Benchimol, C.; Lopes, D.; Bernardino, L.; Do Rosário, V.E.; Varandas, L.; Nogueira, F.. "Prevalence of pfmdr1, pfcrt, pfdhfr and pfdhps mutations associated with drug resistance, in Luanda, Angola". Malaria Journal 7 (2008): http://www.scopus.com/inward/record.url?eid=2-s2.0-58149241174&partnerID=MN8TOARS.
10.1186/1475-2875-7-236
Andrade-Neto, V.F.; Brandão, M.G.L.; Nogueira, F.; Rosário, V.E.; Krettli, A.U.. "Corrigendum to "Ampelozizyphus amazonicus Ducke (Rhamnaceae), a medicinal plant used to prevent malaria in the Amazon Region, hampers the development of Plasmodium berghei sporozoites" in [Int. J. Parasitol. 38 (2008) 1505-1511] (DOI:10.1016/j.ijpara.2008.05.007)". International Journal for Parasitology 38 14 (2008): http://www.scopus.com/inward/record.url?eid=2-s2.0-55249104306&partnerID=MN8TOARS.
10.1016/S0020-7519(08)00399-8
Andrade-Neto, V.F.; Brandão, M.G.L.; Nogueira, F.; Rosário, V.E.; Krettli, A.U.. "Ampelozyziphus amazonicus Ducke (Rhamnaceae), a medicinal plant used to prevent malaria in the Amazon Region, hampers the development of Plasmodium berghei sporozoites". International Journal for Parasitology 38 13 (2008): 1505-1511. http://www.scopus.com/inward/record.url?eid=2-s2.0-53049088303&partnerID=MN8TOARS.
10.1016/j.ijpara.2008.05.007
Portela, C.; Afonso, C.M.M.; Pinto, M.M.M.; Lopes, D.; Nogueira, F.; do Rosário, V.. "Synthesis and antimalarial properties of new chloro-9H-xanthones with an aminoaikyl side chain". Chemistry and Biodiversity 4 7 (2007): 1508-1519. http://www.scopus.com/inward/record.url?eid=2-s2.0-34547553741&partnerID=MN8TOARS.
10.1002/cbdv.200790130
Nogueira, F.; Gil, J.P.; Rosário, V.E.. "Efflux pumps of antimalarial-resistance in Plasmodium falciparum". Antibiotiques 8 2 (2006): 85-92. https://www.sciencedirect.com/science/article/pii/S1294550106708020.
Published • 10.1016/S1294-5501(06)70802-0
Pimentel, S.; Nogueira, F.; Benchimol, C.; Quinhentos, V.; Bom, J.; Varandas, L.; Do Rosário, V.; Bernardino, L.. "Detection of atovaquone-proguanil resistance conferring mutations in Plasmodium falciparum cytochrome b gene in Luanda, Angola". Malaria Journal 5 (2006): http://www.scopus.com/inward/record.url?eid=2-s2.0-33746322417&partnerID=MN8TOARS.
10.1186/1475-2875-5-30
"Efflux pumps of antimalarial-resistance in Plasmodium falciparum". Antibiotiques (2006): https://publons.com/publon/15915951/.
10.1016/S1294-5501(06)70802-0
Dahlstrom, S.; Sisowath, C.; Nogueira, F.; Martensson, A.; Bjoerkman, A.; Gil, J.. "Size variations in a P. falciparu multidrug resistance protein (PfMRP) homologue and Coartem and artesunate plus amodiaquine clinical response [MIM-SD-175726]". Acta Tropica (2005): https://publons.com/publon/21941270/.
Ferreira, I.D.; Nogueira, F.; Borges, S.T.; Do Rosário, V.E.; Cravo, P.. "Is the expression of genes encoding enzymes of glutathione (GSH) metabolism involved in chloroquine resistance in Plasmodium chabaudi parasites?". Molecular and Biochemical Parasitology 136 1 (2004): 43-50. http://www.scopus.com/inward/record.url?eid=2-s2.0-2342479718&partnerID=MN8TOARS.
10.1016/j.molbiopara.2004.02.008
Bagot, S.; Nogueira, F.; Collette, A.; Do Rosario, V.; Lemonier, F.; Cazenave, P.-A.; Pied, S.. "Comparative Study of Brain CD8+ T Cells Induced by Sporozoites and Those Induced by Blood-Stage Plasmodium berghei ANKA Involved in the Development of Cerebral Malaria". Infection and Immunity 72 5 (2004): 2817-2826. http://www.scopus.com/inward/record.url?eid=2-s2.0-2142652154&partnerID=MN8TOARS.
10.1128/IAI.72.5.2817-2826.2004
Cravo, P.; Figueiredo, S.; Nogueira, F.; Lopes, D.; Ferreira, I.D.; Ferreira, C.; Gil, J.P.; Do Rosário, V.E.. "High frequency of the genetic polymorphisms associated with sulfadoxine-pyrimethamine resistance, among Plasmodium falciparum isolates from São Tomé and Príncipe, West Africa". Annals of Tropical Medicine and Parasitology 98 3 (2004): 293-296. http://www.scopus.com/inward/record.url?eid=2-s2.0-2342612193&partnerID=MN8TOARS.
10.1179/000349804225003262
Gil, J.P.; Nogueira, F.; Strömberg-Nörklit, J.; Lindberg, J.; Carrolo, M.; Casimiro, C.; Lopes, D.; et al. "Detection of atovaquone and Malarone™ resistance conferring mutations in Plasmodium falciparum cytochrome b gene (cytb)". Molecular and Cellular Probes 17 2-3 (2003): 85-89. http://www.scopus.com/inward/record.url?eid=2-s2.0-12444295411&partnerID=MN8TOARS.
10.1016/S0890-8508(03)00006-9
Lopes D; Rungsihirunrat K; Nogueira F; Seugorn A; Gil JP; do Rosário VE; Cravo P; et al. "Molecular characterisation of drug-resistant Plasmodium falciparum from Thailand.". Malaria Journal 1 (2002): 1-11. http://europepmc.org/abstract/med/12423551.
10.1186/1475-2875-1-12
Lopes, D.; Nogueira, F.; Gil, J.P.; Ferreira, C.; Do Rosário, V.E.; Cravo, P.. "pfcrt and pfmdr1 mutations and chloroquine resistance in Plasmodium falciparum from São Tomé and Príncipe, West Africa". Annals of Tropical Medicine and Parasitology 96 8 (2002): 831-834. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036976119&partnerID=MN8TOARS.
10.1179/000349802125002284
Nogueira, Fátima; Luisa Botelho, M.; Tenreiro, Rogério; Nogueira, F.; Botelho, M.L.; Tenreiro, R.. "Radioresistance studies in Methylobacterium spp.". Radiation Physics and Chemistry 52 1-6 (1998): 15-19. http://dx.doi.org/10.1016/s0969-806x(98)00024-3.
10.1016/s0969-806x(98)00024-3

Preprint

Ramos S; Ademolue TW; Jentho E; Wu Q; Guerra J; Martins R; Pires G; et al. "A HYPOMETABOLIC DEFENSE STRATEGY AGAINST PLASMODIUM INFECTION". Preprint. 2021. http://europepmc.org/abstract/PPR/PPR393056.
10.1101/2021.09.08.459402

Intellectual property

Patent

nogueira, fatima. 2019. "WO 2021/033159 A1 PYRAZINO [1,2-B]QUINAZOLINE-3,6-DIONES DERIVATIVES, THEIR PRODUCTION AND USES THEREOF".
Pending
nogueira, fatima. 2019. "US20180186713 Antimalarial agent, methods and uses". United States.
Granted/Issued

Other

Other output

Half- Sandwich cyclopentadienylruthenium(II) Complexes: A New Antimalarial Chemotype. 2020. Milheiro SA; Gonçalves J; Lopes R; Madureira M; Lobo L; Lopes A; Nogueira F; et al. http://europepmc.org/abstract/PPR/PPR153029.
10.26434/chemrxiv.12155178.v1
Structure of Hierridin C, Synthesis of Hierridins B and C, and Evidence for Prevalent Alkylresorcinol Biosynthesis in Picocyanobacteria. Small, single-celled planktonic cyanobacteria are ubiquitous in the world's oceans yet tend not to be perceived as secondary metabolite-rich organisms. Here we report the isolation and structure elucidation of hierridin C, a minor metabolite obtained from the cultured picocyanobacterium Cyanobium sp. LEGE 06113. We describe a simple, straightforward synthetic route to the scarcely produced hierrid. 2019. Costa, Margarida; Sampaio-Dias, Ivo E.; Castelo-Branco, Raquel; Scharfenstein, Hugo; Rezende de Castro, Roberta; Silva, Artur; Schneider, Maria Paula C.; et al. http://hdl.handle.net/10400.22/12978.
10.1021/acs.jnatprod.8b01038
Quantitative proteomics for the analysis of Plasmodium falciparum and its red blood cell host - a preliminary study. 2014. Patrícia Machado; Tiago R Vaz; f nogueira; João Rodrigues; Licínio Manco; Letícia Ribeiro; Ed Bergstrom; et al. https://novaresearch.unl.pt/en/publications/6ce3a4ea-127e-4b0b-9663-d686f1360621.
10.1186/1475-2875-13-S1-P74

Activities

Supervision

	Thesis Title Role	Degree Subject (Type) Institution / Organization
2022/01/26 - Current	Clinical and parasitological response at day 7 after treatment of Plasmodium falciparum malaria with ACTs and their correlation with molecular markers of drug resistance in Banga, Angola Supervisor of Mbueno Nzila	DOUTORAMENTO EM DOENÇAS TROPICAIS E SAÚDE GLOBAL/TROPICAL DISEASES AND GLOBAL HEALTH (PhD) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal Universidade Agostinho Neto, Angola
2021/11/24 - Current	Plasmodium falciparum redox system: the role of heterocycle thiosemicarbazones derivatives as potential regulators Supervisor of Denise Maria Figueiredo Araújo Duarte	DOUTORAMENTO EM DOENÇAS TROPICAIS E SAÚDE GLOBAL/TROPICAL DISEASES AND GLOBAL HEALTH (PhD) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal Universidade Federal de Pernambuco, Brazil
2020 - Current	in vitro killing rates of anti-malarial compounds Supervisor of Tiago Santos	Parasitologia Médica (Master) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2020 - Current	Custom dual-indexing and Illumina NGS to study drug resistant malaria Co-supervisor of Brigite Dias	Ciências Biomédicas (Master) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2019/10/01 - Current	Antimalarial Resistance in Mozambique: Characterization of molecular markers and assessment of susceptibility to Plasmodium falciparum Supervisor of Clemente da Silva	Doutoramento em Ciências Biomédicas (PhD) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2019/10 - Current	Serum leptin and malnutrition in children with severe malaria in Mozambique Supervisor	Doenças Tropicais e Saúde Global (PhD) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2019/05 - Current	Eficácia do tratamento da malária à base de artemisinina-lumefantrina e artesunato amodiaquina. Associação com os polimorfismos genéticos. Co-supervisor of Pedro Rafael Dimbu	CIÊNCIAS BIOMÉDICAS (PhD) Universidade Agostinho Neto, Angola
2019 - Current	Exploring bioorganometallic compounds with ferrocene moietis as antimalarials Supervisor of Beatriz Duarte	Ciências Biomédicas (Master) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2019 - Current	Interruption of gametocyte to ookinete development Supervisor of Jessica Fernandes	Ciências Biomédicas (Master) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2020/09/01 - 2022/03/14	Interruption of gametocyte to ookinete development Supervisor	MESTRADO EM CIÊNCIAS BIOMÉDICAS (Master) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2020/09/01 - 2022/02/24	Ionic Liquids Applications as Antimalarial Drugs Supervisor of Tiago Santos	MESTRADO EM PARASITOLOGIA MÉDICA /MASTER IN MEDICAL PARASITOLOGY (Master) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2020/09/01 - 2021/12/14	Imported malaria in Portugal: a molecular perspective of CHLO and IHMT between 2014 and 2021 Supervisor of Débora Serrano	MESTRADO EM SAÚDE TROPICAL /MASTER IN TROPICAL HEALTH (Master) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2020/09/01 - 2021/09/24	Exploring bioorganometallic compounds with ferrocene moietis as antimalarials Supervisor	MESTRADO EM CIÊNCIAS BIOMÉDICAS (Master) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2019 - 2021	Identification of a potential malaria biomarker Co-supervisor of Raquel Cardoso	Ciências Biomédicas (Master) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2016 - 2020/05/28	Characterization of Plasmodium falciparum antigens as candidates for the development of serological tests or candidates for vaccines for malaria. Co-supervisor of Yorleydy Ruiz Moreno	Ciências Biomédicas (PhD) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2016 - 2019/05/14	In vitro characterization of the antimalarial activity and mode of action of new PDEs and DHODH inhibitors against Plasmodium falciparum Supervisor of Jessy Silva	Parasitologia Médica (Master) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2016 - 2019/01/11	Study of polymorphisms associated with P. falciparum resistance to ACTs in East Timor: Estudo da presença de polimorfismos associados à resistência de P. falciparum aos ACTs em Timor Leste Supervisor of Patricia Duarte	Parasitologia Médica (Master) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2015 - 2019	Study of antimalarial activity of new endoperoxides: potential parasite targets and mechanisms of action Supervisor of Lis Lobo	Doutoramento em Ciências Biomédicas (PhD) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2016/10 - 2018/12	To be or not to be transmited, what is in the question? Co-supervisor of Rafael Oliveira	Ciências Biomédicas (Master) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2014/01 - 2018/12	Estudo da atividade anti-malárica e anti-toxoplásmica de endoperóxidos sintéticos: alvos parasitários e mecanismo de acção Supervisor in Portugal: Fátima Nogueira (IHMT/UNL, Lisbon, Portugal) Supervisor in Brazil: Valter Ferreira de Andrade Neto (UFRJ, Natal, Brazil) Supervisor of Lis Tavares Coelho Lobo	Ciências Biomédicas (PhD) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2016/10 - 2018/04	Antimalarial activity characterization of new quinazolinone derivatives Supervisor of Vera Camões	Ciências Biomédicas (Master) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2014/10 - 2017	Searching for SNPs in Plasmodium falciparum drug-resistance associated genes in East Timor Supervisor of Joana Meda	Ciências Biomédicas (Master) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2014/10 - 2017	New quinolones and phosphodiesterase inhibitors as antimalarials. Supervisor of Cátia Nascimento	Saúde Tropical (Master) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2012 - 2017	Estudo farmacodinâmico, em modelo murino-Plasmodium berghei, de compostos quimicamente definidos isolados de plantas usadas popularmente contra a malária e análise de genes de resistência aos antimaláricos em P. falciparum Co-supervisor of Valeska Santana de Sena Pereira	Universidade Federal do Rio Grande do Norte, Brazil
2016/05/16 - 2016/07/21	Training in Methods in malaria research. Sending Institution: Istituto Tecnico Superiore ITS Biomedicale em Mirandola, Italy. Supervisor of Federico Gilioli	ERASMUS+ (Other) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2014/10 - 2016/04	Towards the endoperoxides mechanism of action - assessment of deleterious effects on tolerant and susceptible parasites Supervisor of Fernanda Murtinheira	Ciências Biomédicas (Master) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2014/10 - 2016	Antimalarial activity mediated by efflux pumps; Actividade antimalárica mediada por bombas de efflux Supervisor of Sílvia Pereira	Ciências Biomédicas (Master) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2010 - 2015/07/31	Estudo da eficácia terapêutica in vivo das combinações terapêuticas baseadas nos derivados da artemisinina no tratamento de malária não complicada em Maputo Supervisor of Elsa da Conceição Lobo	Ciências Biomédicas (PhD) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2013/10 - 2015/07	Estudo de polimorfismos no gene que codifica a proteína kelch K13, um marcador de resistência às artemisininas, em Moçambique e Angola Co-supervisor of Carlos Gil Escobar	Saúde Tropical (Master) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2013 - 2015	The antimalarials quest: Is ß- hematin a valid surrogate for native hemozoin? Co-supervisor of Simão Nunes Paula	Tecnologias Biomédicas (Master) Universidade de Lisboa Instituto Superior Técnico, Portugal
2014 - 2014	Efflux pump-mediated activity of antimalarials” The student was trained in laboratorial techniques of Plasmodium falciparum in vitro culture, directed for the evaluation of antimalarial activity of candidate drugs. By the end of the training period, the trainee should be able to design, plan and execute independently laboratorial experiments aimed to characterize the parasite response to different efflux pumps inhibitors and their modulator effect on the antimalarials. Sending Institution: Jagiellonian University in Kraków, Poland Supervisor of Karolina Chmielewska	ERASMUS (Other) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2013/06 - 2013/09	Acquiring P. falciparum in-vitro culture skills for various purposes, especially in biological studies of the parasite and evaluation of the antimalarial activity in-vitro of new compounds. The student also implemented and optimized an assay based on the inhibition of the reaction GSH-haemin (fro drug screening) and tested sixteen new antimalarial candidate compounds. Sending institution: Universidad Complutense de Madrid. Madrid, Spain Supervisor of Jaime Manzano	ERASMUS (Other) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2010/10 - 2012	Estudo da eficácia terapêutica de novos trioxolanos em estirpes sensíveis e resistentes à artemisinina e artesunato Supervisor of Lis Coelho	Parasitologia Médica (Master) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2009 - 2011	Study of the gametocytocidal activity of primaquine derivatives; Estudo da actividade gametocitocida de derivados da primaquina Supervisor of Elia Cabrita	Parasitologia Médica (Master) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal

Event organisation

	Event name Type of event (Role)	Institution / Organization
2019/01 - Current	Malaria outbreak in Cape Verde on 2017: results presentation. at Instituto Nacional de Saúde Publica de Cabo Verde, Praia, Cape Verde. (2019/01) Meeting (Co-organisor)
2018/04 - Current	Caracterização molecular de Plasmodium Falciparum em Cabo Verde (hands on workshop) Joint organization NOVA_IHMT and with Instituto Nacional de Saúde Publica de Cabo Verde at Praia, Cape Verde. (2018/04) Workshop (Co-organisor)	Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2014/11/20 - 2014/11/21	Host – pathogen interaction. Towards a personalized medicine (2014/11/20 - 2014/11/21) Round table (Co-organisor)	Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2009/01/18 - 2009/02/01	Scientific and pedagogic sessions as part of the CMDT LA PhD program in collaboration with Direcção Nacional de Saúde Pública de Angola. Organized by CMDT-LA/IHMT, Lisbon; Portugal and Direcção Nacional de Saúde Pública de Angola (Instituto Nacional de Saúde d Angola – INSA), Luanda; Angola (2009) Workshop (Co-organisor)	Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal

Jury of academic degree

	Topic Role	Candidate name (Type of degree) Institution / Organization
2020/12/04	Discovery of protein aggregation in Plasmodium parasites and development of a combinational antimalarial therapy at the nanoscale Thesis Member	ARNAU BIOSCA ROMANILLOS (PhD) Universitat de Barcelona; Facultat de Farmacia i Ciències de l’Alimentació, Spain
2019/04	TAXI – Targeting Antimalarial eX-star drugs for Intracellular delivery (Thesis) Arguer	Luisa Aguiar Tavares da Silva (PhD) Universidade do Porto Faculdade de Ciências, Portugal
2016/03	Medicinal Chemistry Approaches to Malaria Drug Discovery (Thesis) Arguer	Sofia Alexandre Santos (PhD) Universidade de Lisboa Faculdade de Farmácia, Portugal
2015/12	Exploration of sulfated polysaccharides as antimalarials and as targeting molecules for nanovector-mediated drug delivery to Plasmodium-infected cells (Thesis) Main arguer	Joana Marques (PhD) Universitat de Barcelona Facultat de Farmacia, Spain
2015/02	Malária. Que factores determinam na industria farmacêutica, a dotação orçamental para a investigação de uma vacina (Thesis) Main arguer	Ana Maria Pina Calado Guerra Ferreira (Master) Universidade de Lisboa Instituto Superior de Ciências Sociais e Políticas, Portugal
2014/12	Evaluation of the involvement of efflux pumps in Schistosoma mansoni praziquantel drug resistance phenotype (Thesis) Main arguer	Tiago Mendes (Master) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2014/11	Characterization of a new malaria vaccine candidate against Plasmodium vivax using genetically modified rodent Plasmodium parasites (Thesis) Main arguer	Miguel Filipe Duarte (Master) Universidade de Lisboa Faculdade de Ciências, Portugal
2013/11	Genotipagem da mutação G829A no gene da piruvato cinase em indivíduos da Guiné-Bissau e sua associação com a malaria (Thesis) Main arguer	Sara Cristina Inês Simões Pateira (Master) Universidade de Lisboa Faculdade de Ciências, Portugal
2013/11	Gene expression during Plasmodium transmission (Thesis) Main arguer	Neuza Arrimar Duarte (Master) Universidade de Lisboa Faculdade de Ciências, Portugal
2012/12/13	Identification of drug resistance determinants in Plasmodium falciparum (Thesis) Arguer	João Marques (Master) Universidade de Aveiro, Portugal
2012/03	Bioprospecting sulfated polysaccharides of seaweeds from the coast of Rio Grande do Norte: characterization of a heterofucan extracted from brown algae Sargassum filipendula that induces apoptosis in HeLa cells (Thesis) Main arguer	Leandro Silva Costa (PhD) Universidade do Estado do Rio Grande do Norte, Brazil
2012/03	Evaluation of the antimalarial activity of extracts and fractions obtained from algae Gracillaria birdiae and Spatoglossum schröederi (Thesis) Main arguer	Gracielle Rodrigues Dantas (Master) Universidade do Estado do Rio Grande do Norte, Brazil
2011/12	Pyruvate kinase deficiency protection against malaria: in vitro evaluation of 2,3-diphosphoglycerate toxicity and Plasmodium falciparum susceptibility (Thesis) Main arguer	Ana Margarida Trancoso Gomes Rosa (Master) Universidade de Lisboa Faculdade de Ciências, Portugal
2011/11/28	Análise serológica e imunoquímica de potenciais antigénios para a pesquisa de anticorpos anti-Plasmodium falciparum em pacientes com malária importada (Thesis) Arguer	Rita Costa (Master) Universidade de Lisboa Faculdade de Ciências, Portugal
2010/07	Study of biological behavior in vitro and in vivo strains of Leishmania infantum (Thesis) Main arguer	Andreia Filipa Ramos Ribeiro de Lemos Albuquerque (Other) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Consulting

	Activity description	Institution / Organization
2016/06/05 - 2016/06/10	Expert evaluator - H2020 Program Evaluation of the topics: INFRAIA-01-2016-2017 & INFRAIA -02-2017 (First stage)

Course / Discipline taught

	Academic session	Degree Subject (Type)	Institution / Organization
2017 - Current	Malaria: Plasmodium spp life cycle; drugs and resistance	Global Health and Tropical Medicine (Doutoramento)	Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2017 - Current	UC coordinator -Thematic Rotation II	Doenças Tropicais e Saúde Global (Doutoramento)	Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2017 - Current	UC Coordinator - Drug resistance genetics in parasitology	Parasitologia Médica (Mestrado)	Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2012 - Current	UC Coordinator - Malária	Parasitologia Médica (Mestrado)	Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2012 - Current	Malaria parasite life cycle and biology.	Ciências Biomédicas (Mestrado)	Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2012 - Current	Malaria drug resistance mechanism and target	Ciências Biomédicas (Mestrado)	Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2012 - Current	In vitro drug susceptibility assays (lectures and practical sessions)	Ciências Biomédicas (Mestrado)	Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2007 - Current	Malaria drug resistance mechanism and targets	Ciências Biomédicas (Doutoramento)	Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2007 - Current	Malaria parasite life cycle and biology	Parasitologia Médica (Mestrado integrado)	Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2007 - Current	Malaria drug resistance mechanism and targets	Parasitologia Médica (Mestrado)	Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2007 - Current	In vitro drug susceptibility assays (lectures and practical sessions)	Parasitologia Médica (Mestrado integrado)	Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2007 - Current	Molecular Parasitology: gene expression (practical session)	Parasitologia Médica (Mestrado integrado)	Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2008 - 2012	TEACHING ACTIVITIES AT the PhD programme, Programa de Pós-Graduação em Biotecnologia/RENORBIO at Universidade Federal do Piauí, Teresina Brazil. Teaching the following subjects: Malaria parasite life cycle and biology (lectures) Malaria drug resistance mechanism and targets (lectures) In vitro drug susceptibility assays (lectures and practical sessions Concepts and application of molecular biology in medical parasitology	(Doutoramento)
2008 - 2012	Malaria parasite life cycle and biology of antimalarials drug resistance	Basic and Applied Biology GABBA (Doutoramento)	Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Journal scientific committee

	Journal title (ISSN)	Publisher
2019 - Current	Journal of Antimicrobial Chemotherapy (1460-2091)	Oxford University Press
2018 - Current	ACS Infectious Diseases (2373-8227)	American Chemical Society
2017 - Current	Antimicrobial Agents and Chemotherapy (1098-6596)	American Society for Microbiology
2017 - Current	Nature (1476-4687)	Springer Nature
2017 - Current	Parasitology International (1383-5769)	Elsevier
2016 - Current	Experimental Parasitology (1090-2449)	Elsevier
2014 - Current	British Biotechnology Journal (2231-2927)	Sciencedomain International
2014 - Current	British Journal of Medicine and Medical Research (2231-0614)	Sciencedomain International
2014 - Current	Journal of Advances in Medical and Pharmaceutical Sciences (2394-1111)	Sciencedomain International
2014 - Current	The Lancet (1474-547X)	Elsevier
2014 - Current	Asian Pacific Journal of Tropical Biomedicine (2221-1691)	Medknow Publications
2014 - Current	plos one
2013 - Current	African Journal of Pharmacy and Pharmacology (1996-0816)	Academic Journals
2011 - Current	Malaria Journal (1475-2875)	Springer (Biomed Central Ltd.)
2008 - Current	Transactions of the Royal Society of Tropical Medicine and Hygiene (1878-3503)	Oxford University Press

Mentoring / Tutoring

	Topic	Student name
2018/09 - Current	Epidemiology and health determinants: contributions to the elimination of malaria in Cape Verde	Júlio Monteiro Rodrigues
2016 - Current	The role of a-gal (Gala1-3Galß1-4GlcNAc-R) on Plasmodium spp. sporozoites interaction with Anopheles spp. mosquito.	Helio Daniel Ribeiro Rocha
2012 - 2017/05	Development of an innovative real-time assay for antimalarial sensitivity testing and interrogation of novel compounds	Maria Rebelo
2010 - 2015	Canine leishmaniosis: the role of hepatocytes and Kupffer cells during Leishmania infantum infection	Maria Armanda Viana Rodrigues

Other jury / evaluation

	Activity description	Institution / Organization
2011/04/01 - Current	Referee/expert for the decision concerning admission of a thesis PhD thesis for evaluation (Artº 4.9 b) y 4.9 c) de la Normativa de desarrollo de los artículos 21 y 22 del R.D. 1393/2007)	Universidad Complutense de Madrid, Spain

Distinctions

Award

2019	Prémio Professor Doutor João Fraga e Azevedo Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2006	Premio do Anuário do Hospital Dona Estefania –Medicine. Hospital Dona Estefânia, Portugal