Hélène Léger (7118-8939-777A)

Curriculum Vitae

Hélène Léger

Dr. Hélène Léger is a molecular biologist specializing in neuroinflammation and retinal degeneration. She has been a researcher at the Faculty of Medicine, University of Coimbra, since 2020. Dr. Léger earned her Ph.D. in Biology and Health Sciences (Molecular and Cell Biology) from the University of Lille 1, France (2012), following a Master’s and Bachelor’s in Cellular Biology and Development from Université Paris-Sud (2006, 2008). During her undergraduate studies, she completed an exchange year at the University of Montréal, Canada, through the CREPUQ program, graduating with an overall grade of A. She also completed the prestigious international course Molecular Biology of the Cell, jointly organized by the Pasteur and Curie Institutes (2008). Dr. Léger began her research career as a postdoctoral fellow at the Fox Chase Cancer Center in Philadelphia (2012–2014), studying the interplay between epigenomic and transcriptional regulation in cancer. She then joined the University of Pennsylvania’s School of Veterinary Medicine (2014–2019), where she explored retinal cell proliferation and differentiation mechanisms using CRISPR-Cas9 gene-editing in mouse models. Her current research focuses on the molecular and cellular mechanisms underlying neuroinflammatory responses in retinal degenerative diseases. She leads a collaborative project with the Laboratory of Instrumentation and Experimental Particle Physics (LIP) on OpticCanvas: Painting the Visual Landscape of Degenerative Vision—an interdisciplinary software tool that models how patients with retinal degeneration perceive their surroundings. An accomplished mentor, Dr. Léger has co-supervised 11 bachelor’s and 5 master’s students, including 3 Erasmus exchange students. She has published 15 peer-reviewed articles (3 as first author, 3 as corresponding author) with an H-index of 9 and 375 citations (Scopus). Dr. Léger is also an active reviewer and guest editor for a special issue on Molecular Mechanisms of Retinal Development and Degeneration in the journal Biology (Q1, open access). Beyond her scientific achievements, Dr. Léger has held leadership and community engagement roles. She chaired the Foreign National Committee for the Biomedical Postdoc Council at the University of Pennsylvania (2016–2019) and co-founded the Women Love Science Club at Fox Chase Cancer Center (2012). She has organized scientific meetings, served as Principal Investigator on multiple research projects, and received four research awards. Committed to science outreach, she regularly participates in initiatives such as the European Researchers’ Night and Low Vision Awareness Month.

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Identificação

Identificação pessoal

Nome completo: Hélène Léger

Nomes de citação

Léger, Hélène

Identificadores de autor

Ciência ID: 7118-8939-777A
ORCID iD: 0000-0003-1116-8637
Researcher Id: AAX-5076-2020
Scopus Author Id: 36448467700

Endereços de correio eletrónico

hleger@uc.pt (Profissional)

Moradas

iCBR, Polo III Health Sciences Campus, Azinhaga de Santa Comba, 3000-548 , Coimbra, Coimbra, Portugal (Profissional)

Domínios de atuação

Ciências Naturais - Ciências Biológicas - Biologia
Ciências Médicas e da Saúde - Medicina Básica - Neurociências
Ciências Médicas e da Saúde - Medicina Básica - Imunologia
Ciências Naturais - Ciências Biológicas - Biologia Molecular
Ciências Naturais - Ciências Biológicas - Biologia Celular
Ciências Médicas e da Saúde - Biotecnologia Médica - Tecnologias que envolvem a Manipulação de Células,Tecidos,Órgãos ou todo o Organismo
Ciências Médicas e da Saúde - Medicina Básica - Patologia

Idiomas

Idioma	Conversação	Leitura	Escrita	Compreensão	Peer-review
Francês (Idioma materno)
Inglês	Utilizador proficiente (C2)	Utilizador proficiente (C2)	Utilizador proficiente (C2)	Utilizador proficiente (C2)	Utilizador proficiente (C2)
Português	Utilizador elementar (A2)	Utilizador independente (B1)	Utilizador elementar (A2)	Utilizador independente (B1)	Utilizador elementar (A2)

Formação

	Grau	Classificação
2023/03/07 - 2023/03/08 Concluído	Flow Cytometry and Cell Sorting Course (Outros) Universidade de Coimbra, Portugal
2021/10/01 - 2021/10/14 Concluído	IV Modular Training in Laboratory Animal Science Function B (Outros) Universidade de Coimbra, Portugal
2021/05/25 - 2021/05/28 Concluído	BioImage Analysis for High Content Screening (Outros) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2019 - 2019 Concluído	Champalimaud pratical course animal Function A (Outros) Centro Champalimaud, Portugal
2008 - 2012 Concluído	PhD in Molecular and cellular biology (Doctorat) Especialização em Biochemistry and Molecular Biology Lille University of Science and Technology, França "Functional study of the roles of the CBP/TDG/RARa complex in epigenetic regulation of the transcription and DNA repair: a link between DNA repair, transcription and epigenetic." (TESE/DISSERTAÇÃO)	Cum Laude
2008/01/15 - 2008/02/15 Concluído	Molecular biology of the cell (Master) Institut Pasteur, França	Cum Laude
2006 - 2008 Concluído	Cellular biology and development (Master) Université Paris-Sud Faculté des Sciences d'Orsay, França "Impact of the serotoninergic network in granulosa cells proliferation in mice model." (TESE/DISSERTAÇÃO)	Cum Laude
2003 - 2006 Concluído	Cellular biology and development (Bachelor) Especialização em Cellular biology and development Université Paris-Sud, França "Screening of Gal4 Drosophila melanogaster lines using GAL4 and GAL80/UAS system and immunohistochemistry" (TESE/DISSERTAÇÃO)

Percurso profissional

Ciência

	Categoria Profissional Instituição de acolhimento	Empregador
2021/06/16 - Atual	Investigador Contratado (Investigação)	Universidade de Coimbra, Portugal

2020/01/02 - 2021/01/15	Investigador Contratado (Investigação)	Universidade de Coimbra, Portugal
	Coimbra Institute for Clinical and Biomedical Research, Portugal
2014/04/21 - 2019/10/31	Pós-doutorado (Investigação)	University of Pennsylvania School of Veterinary Medicine, Estados Unidos

2012/09/21 - 2014/03/28	Pós-doutorado (Investigação)	Fox Chase Cancer Center, Estados Unidos

Cargos e Funções

	Categoria Profissional Instituição de acolhimento	Empregador
2007 - 2008	Internship (Master)	Laboratoire de génétique moléculaire de la neurotransmission et des processus neurodégénératif - Hôpital de la Pitié-Salpétrière, França

2007 - 2007	Internship (Master)	Centre Hospitalier de L'Universite de Montreal, Canadá

2004 - 2004	Internship (Bachelor)	Université Paris-Sud, França

Outros

	Categoria Profissional Instituição de acolhimento	Empregador
2021/01/16 - 2021/06/14	Maternity Leave	N/A, Portugal

2008/09/01 - 2012/04/30	PhD Student	Université de Lille, França
	Institut des Hautes Études Scientifiques, França
2008 - 2012	PhD Student	Université de Lille, França

Projetos

Bolsa

	Designação	Financiadores
2025 - 2028	Decifrando o papel da cinase Ndr2 na vascularização induzida pela microglia na retinopatia diabética 15895 Investigador responsável Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra, Portugal	Fundação para a Ciência e a Tecnologia
2023/01 - 2024/06	Ndr2 kinase: a novel player in the regulation of microglia in Diabetic Retinopathy 2022.06170.PTDC Investigador responsável	Fundação para a Ciência e Tecnologia Em curso
2016 - 2019	Investigate the molecular mechanisms of NDR kinases and their substrates on cell division and cell fate in the retina unknown Investigador Pós-doutorado University of Pennsylvania, Estados Unidos	University of Pennsylvania
2014 - 2019	Examining the role of Cbk1/NDR kinase in regulating mRNA localization 5R01GM097327-03 Investigador Pós-doutorado	National Institute of General Medical Sciences Concluído
2008 - 2012	Epigenomic Regulation by Thymine-DNA Glycosylase Complexes unknown Bolseiro de Doutoramento	Genopole Concluído

Projeto

	Designação	Financiadores
2020/01/01 - Atual	Investigate the mechanisms of NDR kinases in inflammation-induced angiogenesis in mouse retinas IT057-19-8135 Investigador responsável Coimbra Institute for Clinical and Biomedical Research, Portugal	Em curso
2020/01 - Atual	The effect of DPP-4 inhibitor sitagliptin on inflammation mediated by microglial cells unknown Investigador	Fundação para a Ciência e a Tecnologia Em curso
2016 - 2019	Investigate the molecular mechanisms of NDR kinases and their substrates in neuronal development 5R01GM097327-03 Investigador Pós-doutorado University of Pennsylvania School of Veterinary Medicine, Estados Unidos	Concluído
2015 - 2016	A Zebrafish model for investigating Ndr kinase-dependent retina development Unknown Investigador Pós-doutorado University of Pennsylvania School of Veterinary Medicine, Estados Unidos	Concluído
2012 - 2014	Functional studies of TDG and its partners in epigenetic regulation of transcription Unknown Investigador Pós-doutorado	Concluído

Outro

	Designação	Financiadores
2006 - 2008	Role of the Serotoninergic network on granulosa cells proliferation and differentiation Unknown Bolseiro de Mestrado	Concluído

Produções

Publicações

Artigo em conferência	Léger, Hélène; Fazendeiro, Beatriz; António Francisco Ambrósio; Santos, Paulo Fernando Martins dos. Autor correspondente: Léger, Hélène. "Ndr2 kinase regulates the microglia inflammatory response in high glucose conditions.". Trabalho apresentado em 2024 ARVO Annual Meeting, Seattle, 2024. Publicado Léger, Hélène; Ambrósio, A.F.. Autor correspondente: Léger, Hélène. "Sitagliptin, a drug for type 2 diabetes, inhibits microglia reactivity triggered by exposure to lipopolysaccharide.". Trabalho apresentado em 16th European Meeting on Glial Cells in Health and Disease, 2023. Aceite para publicação Léger, Hélène; Ambrósio, A.F.. Autor correspondente: Léger, Hélène. "The Dipeptidyl Peptidase 4 (DPP-4) Inhibitor, Sitagliptin, Exerts Direct Anti-inflammatory Effects on Microglial Cells". 2023.
Artigo em revista	Fazendeiro, Beatriz; Machado, Ivo; Rolo, Anabela; Rodrigues Santos, Paulo; Ambrósio, António Francisco; Santos, Paulo F.; Léger, Hélène. Autor correspondente: Léger, Hélène. "NDR2 Kinase Regulates Microglial Metabolic Adaptation and Inflammatory Response: Critical Role in Glucose-Dependent Functional Plasticity". International Journal of Molecular Sciences 26 21 (2025): 10630. https://doi.org/10.3390/ijms262110630. Aceite para publicação • 10.3390/ijms262110630 Paulo F. Santos; António Francisco Ambrósio; Hélène Léger. "The Importance of Kinases in Retinal Degenerative Diseases". Kinases and Phosphatases (2024): https://doi.org/10.3390/kinasesphosphatases2010006. 10.3390/kinasesphosphatases2010006 Santos, Paulo F.; Fazendeiro, Beatriz; Luca, Francis C.; Ambrósio, António Francisco; Léger, Hélène. "The NDR/LATS protein kinases in neurobiology: Key regulators of cell proliferation, differentiation and migration in the ocular and central nervous system". European Journal of Cell Biology 102 2 (2023): 151333. http://dx.doi.org/10.1016/j.ejcb.2023.151333. 10.1016/j.ejcb.2023.151333 Léger, Hélène; Santos, Paulo Fernando Martins dos. Autor correspondente: Léger, Hélène. "The NDR/LATS protein kinases in neurobiology: key regulator of cell proliferation, differentiation and migration in the ocular and central nervous system". European Journal of Cell Biology (2023): Em revisão Morley-Fletcher, Sara; Marrocco, Jordan; Leger, Helène; Mairesse, Jerome; Reynaert, Marie-Line; Van Camp, Gilles; Bouwalerh, Hammou; et al. "Grandma's stress programs transgenerational transmission of hippocampal glutamatergic synaptopathy associated with stress-related responses". Psychoneuroendocrinology 107 (2019): 58. http://dx.doi.org/10.1016/j.psyneuen.2019.07.168. Publicado • 10.1016/j.psyneuen.2019.07.168 Léger, Hélène. "Preparation of Mouse Retinal Cryo-sections for Immunohistochemistry.". Journal of visualized experiments : JoVE (2019): https://doi.org/10.3791/59683. 10.3791/59683 Hélène Léger; Evelyn Santana; N. Adrian Leu; Eliot T. Smith; William A. Beltran; Gustavo D. Aguirre; Francis C. Luca. "Ndr kinases regulate retinal interneuron proliferation and homeostasis". Scientific Reports 8 1 (2018): https://doi.org/10.1038/s41598-018-30492-9. 10.1038/s41598-018-30492-9 Kamtchueng, Catherine; Stébenne, Marie-Éve; Delannoy, Aurélie; Wilhelm, Emmanuelle; Léger, Hélène; Benecke, Arndt G.; Bell, Brendan. "Alternative Splicing of TAF6: Downstream Transcriptome Impacts and Upstream RNA Splice Control Elements". PLoS ONE 9 7 (2014): e102399. http://dx.doi.org/10.1371/journal.pone.0102399. 10.1371/journal.pone.0102399 Léger, Hélène; Smet-Nocca, Caroline; Attmane-Elakeb, Amel; Morley-Fletcher, Sara; Benecke, Arndt G.; Eilebrecht, Sebastian. "A TDG/CBP/RARa Ternary Complex Mediates the Retinoic Acid-dependent Expression of DNA Methylation-sensitive Genes". Genomics, Proteomics & Bioinformatics 12 1 (2014): 8-18. http://dx.doi.org/10.1016/j.gpb.2013.11.001. 10.1016/j.gpb.2013.11.001 Moreno, Griselda; Errea, Agustina; Van Maele, Laurye; Roberts, Roy; Léger, Hélène; Sirard, Jean Claude; Benecke, Arndt; Rumbo, Martin; Hozbor, Daniela. "Toll-like receptor 4 orchestrates neutrophil recruitment into airways during the first hours of Bordetella pertussis infection". Microbes and Infection 15 10-11 (2013): 708-718. http://dx.doi.org/10.1016/j.micinf.2013.06.010. 10.1016/j.micinf.2013.06.010 Ivanov, S.; Fontaine, J.; Paget, C.; Macho Fernandez, E.; Van Maele, L.; Renneson, J.; Maillet, I.; et al. "Key Role for Respiratory CD103+ Dendritic Cells, IFN- , and IL-17 in Protection Against Streptococcus pneumoniae Infection in Response to -Galactosylceramide". Journal of Infectious Diseases 206 5 (2012): 723-734. http://dx.doi.org/10.1093/infdis/jis413. 10.1093/infdis/jis413 Marqués, Juan M.; Rial, Analía; Muñoz, Natalia; Pellay, Francois-Xavier; Van Maele, Laurye; Léger, Hélène; Camou, Teresa; et al. "Protection against Streptococcus pneumoniae serotype 1 acute infection shows a signature of Th17- and IFN-¿-mediated immunity". Immunobiology 217 4 (2012): 420-429. http://dx.doi.org/10.1016/j.imbio.2011.10.012. 10.1016/j.imbio.2011.10.012 Smet-Nocca, Caroline; Wieruszeski, Jean-Michel; Léger, Hélène; Eilebrecht, Sebastian; Benecke, Arndt. "SUMO-1 regulates the conformational dynamics of Thymine-DNA Glycosylase regulatory domain and competes with its DNA binding activity". BMC Biochemistry 12 1 (2011): 4. http://dx.doi.org/10.1186/1471-2091-12-4. 10.1186/1471-2091-12-4 Eilebrecht, S.; Bécavin, C.; Léger, H.; Benecke, B.-J.; Benecke, A.; Eilebrecht, Sebastian; Bécavin, Christophe; et al. "HMGA1-dependent and independent 7SK RNA gene regulatory activity". RNA Biology 8 1 (2011): 143-157. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952213061&partnerID=MN8TOARS. 10.4161/rna.V.I.14261 Van Maele, L.; Carnoy, C.; Cayet, D.; Songhet, P.; Dumoutier, L.; Ferrero, I.; Janot, L.; et al. "TLR5 Signaling Stimulates the Innate Production of IL-17 and IL-22 by CD3negCD127+ Immune Cells in Spleen and Mucosa". The Journal of Immunology 185 2 (2010): 1177-1185. http://dx.doi.org/10.4049/jimmunol.1000115. 10.4049/jimmunol.1000115 Ladam, F.; Leger, H.; Kherrouche, Z.; Tulasne, D.; Benecke, A.; de Launoit, Y.; Chotteau-Lelièvre, A.. "Characterization of the transcriptional networks involving PEA3 transcription factors during mammary morphogenesis and tumourigenesis". European Journal of Cancer Supplements 8 5 (2010): 91. http://dx.doi.org/10.1016/s1359-6349(10)71158-7. 10.1016/s1359-6349(10)71158-7
Poster em conferência	Alarico, Su; Afonso M.; Alves A.; Amaral S.; Amorim R.; Candeias E.; Cardoso M.; et al. "GreenLabsCiBB: One path for sustainable research.". Trabalho apresentado em EU-LIFE 10th Anniversary Conference. Calouste Gulbenkian Foundation., 2023. Léger, Hélène. "NDR kinases regulate amacrine cell proliferation and homeostasis". Trabalho apresentado em ISER's XXIII Biannual Meeting, 2018. Léger, Hélène. "NDR kinases regulate retinal development". Trabalho apresentado em 2017 Mid Atlantic Meiosis Meeting, 2017. Léger, Hélène. "NDR kinases regulate retinal development, homeostasis and gene expression". Trabalho apresentado em ARVO 2017, 2017. Léger, Hélène. "Role of NDR kinases in retina development". Trabalho apresentado em Biomedical Sciences Retreat - University of Pennsylvania, Department of Biomedical Sciences, 2016. Léger, Hélène. "Involvement of the DNA repair and epigenetic factor Thymine DNA Glycosylase in congenital heart disease". Trabalho apresentado em Fox Chase Cancer Center, 2013. Léger, Hélène. "Functional studies of CBP/TDG complexes reveal a close link between DNA repair, transcription, and epigenetic signaling". 2011.
Pré-impressão	Beatriz Fazendeiro; Ivo Machado; Anabela Rolo; Paulo Rodrigues-Santos; António Francisco Ambrósio; Paulo F. Santos; Hélène Léger. "NDR2 Kinase Regulate Microglial Metabolic Adaptation and Inflammatory Response: Critical Role in Glucose-Dependent Functional Plasticity". 2025. https://doi.org/10.1101/2025.06.12.659313. 10.1101/2025.06.12.659313
Resumo em conferência	Léger, Hélène; Fazendeiro, Beatriz; Santos, Paulo Fernando Martins dos. Autor correspondente: Léger, Hélène. "NDR2 KINASE REGULATES MICROGLIAL CELLS IN DIABETIC RETINOPATHY". Trabalho apresentado em EUROPEAN JOURNAL OF OPHTHALMOLOGY, 2024. Aceite para publicação Léger, Hélène; Ambrósio, A.F.. "Sitagliptin, an anti-diabetic drug, inhibits the pro-inflammatory microglia reactivity via dipeptidyl peptidase-4 (DPP4).". Trabalho apresentado em 2023 European Association for Vision and Eye Research Festival,, 2023. https://doi.org/10.1111/aos.15833 Léger, Hélène; Ambrósio, A.F.. Autor correspondente: Léger, Hélène. "Sitagliptin, a drug for type 2 diabetes, significantly inhibits the pro-inflammatory microglia reactivity". Trabalho apresentado em 2023 ARVO Annual Meeting, 2023. Aceite para publicação
Tese / Dissertação	Léger, Hélène. "Functional study of the roles of the CBP/TDG/RARa complex in epigenetic regulation of the transcription and DNA repair: a link between DNA repair, transcription and epigenetic.". Doutoramento, Université de Lille, 2012.

Outros

Software

Léger, Hélène; Barros, N; Santos, Paulo Fernando Martins dos. "OpticCanvas: Painting the Visual Landscape of Degenerative Vision". Coimbra Institute for Clinical and Biomedical Research. 2023.

Atividades

Apresentação oral de trabalho

	Título da apresentação	Nome do evento Anfitrião (Local do evento)
2023/03/15	Ndr2 kinase: a novel player in the regulation of microglia in Diabetic Retinopathy	Cursos Avançados: Ciências da Visão FMUC (Portugal)
2022/11/03	Ndr2 kinase: a novel player in the regulation of microglia in Diabetic Retinopathy	RMT 2022 FMUC (Portugal)
2022/10/20	Deciphering the role of Ndr2 Hippo kinase in retinal vascularization	2nd International Symposium on Retina and Choroidal Angiogenesis Université de Montréal (Montréal, Canadá)
2019	Seminar - NDR kinases role in inflammation-induced angiogenesis in mouse retina	iCBR - Retinal Dysfunction & Neuroinflammation Lab
2019	Seminar - Ndr 1 and Ndr2 kinases regulate retinal cell proliferation and homeostasis	Instituto de Medicina Molecular João Lobo Antunes - Leonor Saúde Lab
2018	NDR kinases regulate amacrine cell proliferation and homeostasis - ISER International Meeting	ISER's XXIII Biennial Meeting International Society for Eye Research (Belfast, Reino Unido)
2017	Role of NDR kinases in retinal homeostasis - National Meeting	Biomedical sciences retreat University of Pennsylvania (Philadelphia, Estados Unidos)
2013/01	Using the Thymine DNA Glycosylase P65A mutant to separate the DNA repair enzym and transcription regulator functions of TDG.
2010	Epigenomics control mechanisms by CBP/TDG complexes	Colloque annuel des doctorants (França)

Orientação

	Título / Tema Papel desempenhado	Curso (Tipo) Instituição / Organização
2025/09 - 2026/06	Ndr2 deletion triggers on retinal inflammation in control and in type I diabetes animals Orientador	Universidade de Coimbra, Portugal
2025/09 - 2026/02	Ndr2 deletion triggers on retinal gliosis Orientador	Universidade de Coimbra, Portugal
2025/01 - 2025/09	Nrf2-Microglia Crosstalk in Diabetic Retinopathy: A Review of Therapeutic Implications for Oxidative Stress and Inflammation Orientador	BSc (Licenciatura/Bacharelato) Universidade de Coimbra, Portugal
2024/09 - 2025/09	Impact of Ndr2 deletion on retinal homeostasis in type I diabetes Orientador	BSc (Licenciatura/Bacharelato) Universidade de Coimbra, Portugal
2024/09 - 2025/06	SITAGLIPTIN'S DIRECT ANTI-INFLAMMATORY ACTION ON MICROGLIA: INVESTIGATING THE ROLE OF DPP-4 IN MODULATING LPS-INDUCED REACTIVITY Orientador	Universidade de Coimbra, Portugal
2024 - 2024	Role of Ndr2 kinase in the crosstalk between microglial cells and endothelial cells Orientador
2022/12/05 - 2023/09/30	Deciphering the functions of Ndr kinases as novel players in the regulation of microglia Coorientador	Mestrado em Biotecnologia Farmaceutica (Mestrado) Universidade de Coimbra, Portugal
2022/09 - 2023/09	Mechanisms of Sitagliptin on the microglial cells with BV-2 as model Coorientador	Mestrado em Engenharia Biome´dica (Mestrado) Universidade de Coimbra, Portugal
2022/09 - 2023/09	DISSECTING THE MECHANISMS U NDERLYING THE A NTI I NFLAMMATORY EFFECTS OF S ITAGLIPTIN ON MICROGLIAL CELLS Orientador	MSc (Mestrado)
2023/02 - 2023/06	Impact of high glucose condition on Ndr kinases expression in microglial cells Orientador	Lic Biologia - Projecto II (Licenciatura/Bacharelato) Universidade de Coimbra, Portugal
2022/11 - 2023/06	Characterization of the direct or indirect anti-inflammatory effects of the anti-diabetic drug sitagliptin on LPS-induced inflammatory response mediated by microglial cells. Coorientador	Mestrado Integrado em Medicina - Investigac¸a~o Aplicada I e III (Mestrado) Universidade de Coimbra, Portugal
2022/09 - 2023/02/16	Effect of the DPP4 inhibitor, Sitagliptin, on LPS-induced inflammation mediated by microglial cells Orientador	Università degli Studi di Salerno, Itália
2022 - 2023	DECIPHERING THE FUNCTIONS OF NDR KINASES AS NOVEL PLAYERS IN THE REGULATION OF MICROGLIA Coorientador
2018 - 2018	Ndr2 deletion impact amacrine cells differentiation Orientador	University of Pennsylvania, Estados Unidos
2015 - 2015	Ndr1/2 expression in neuronal tissues Orientador
2013 - 2013	Cardivascular defect in TDG -/- mice Orientador	Fox Chase Cancer Center, Estados Unidos

Organização de evento

	Nome do evento Tipo de evento (Tipo de participação)	Instituição / Organização
2024 - Atual	Seminar to raise awareness for low vision diseases and aged-macular degeneration (2024/01/25 - 2024/03/01) Exposição (Coorganizador)	Universidade de Coimbra, Portugal
2025 - 2025	Seminar to raise awareness for low vision diseases and aged-macular degeneration (2025/02/01 - 2025/03/01) Oficina (workshop)	Universidade de Coimbra, Portugal
2023/02/01 - 2023/02/28	Series of short seminars associated with an interactive activity during the Low vision awareness (2022/02/06 - 2023/02/09) Exposição (Coorganizador)	Universidade de Coimbra, Portugal
2023/02/01 - 2023/02/28	Seminar to raise awareness for low vision diseases and aged-macular degeneration (2023/02/23 - 2023/02/23) Seminário (Coorganizador)	Universidade de Coimbra, Portugal
2017/01/01 - 2019/09/30	Networking events - The Foreign National Committee organize a monthly Tea Time to allow postdocs meet, interact and establish valuable contacts within the different departments of the University of Pennsylvania. (2017/01/01 - 2019/09/30) Outro (Coorganizador)	University of Pennsylvania School of Veterinary Medicine, Estados Unidos University of Pennsylvania Perelman School of Medicine, Estados Unidos
2016/01/15 - 2019/08/31	Networking events - The Foreign National Committee organize a monthly Orientation to welcome Foreign National postdocs to the University of Pennsylvania (2016/01/01 - 2019/08/31) Outro (Coorganizador)	University of Pennsylvania School of Veterinary Medicine, Estados Unidos University of Pennsylvania Perelman School of Medicine, Estados Unidos
2019/03/01 - 2019/06/30	Immigration Seminar - The Foreign National Committee organize an annual Immigration Seminar featuring Dr. Brendan Delaney, partner at Leavy, Frank and Delaney who will present some essential tips on US immigration. (2019/06/13 - 2019/06/13) Seminário (Coorganizador)	University of Pennsylvania School of Veterinary Medicine, Estados Unidos University of Pennsylvania Perelman School of Medicine, Estados Unidos
2018/03/01 - 2018/08/30	Immigration Seminar - The Foreign National Committee organize an annual Immigration Seminar featuring Dr. Brendan Delaney, partner at Leavy, Frank and Delaney who will present some essential tips on US immigration. (2018/08/17 - 2018/08/17) Seminário (Presidente da Comissão Organizadora)	University of Pennsylvania School of Veterinary Medicine, Estados Unidos University of Pennsylvania Perelman School of Medicine, Estados Unidos
2017/03/01 - 2017/06/30	Immigration Seminar - The Foreign National Committee organize an annual Immigration Seminar featuring Dr. Brendan Delaney, partner at Leavy, Frank and Delaney who will present some essential tips on US immigration. (2017/06/22 - 2017/06/22) Seminário (Presidente da Comissão Organizadora)	University of Pennsylvania School of Veterinary Medicine, Estados Unidos University of Pennsylvania Perelman School of Medicine, Estados Unidos

Participação em evento

	Descrição da atividade Tipo de evento	Nome do evento Instituição / Organização
2023 - 2025	Picnic com Saúde @CBR Festival	Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra, Portugal
2020 - 2025	Noite Europeia dos Investigadores 1 / year Festival	Universidade de Coimbra, Portugal
2020 - 2025	National Science Week 1 week / year initiative to promote scientific culture, STEM education, and public engagement Oficina (workshop)	Universidade de Coimbra, Portugal
2023/04 - 2023/04	"Veja" o mundo como um doente com patologias da visão Exposição	FMUC Alunos 9º ano Universidade de Coimbra Faculdade de Medicina, Portugal
2022 - 2022	FIC.a 2022
2022 - 2022	European night of the investigator Exposição

Júri de grau académico

	Tema Tipo de participação	Nome do candidato (Tipo de grau) Instituição / Organização
2025	master defense Orientador	João Luís Santos Ribeiro (Mestrado) Universidade de Coimbra Faculdade de Farmácia, Portugal
2024/09/11	Master's Degree in Cellular and Molecular Biology Arguente principal	Mariana Cardoso Ribeiro (Mestrado) Universidade de Coimbra, Portugal
2023	PhD defense Arguente	Yasmine Zeroual (Doutoramento) Université de Lille, França
2023	Master defense Orientador	Beatriz Fazendeiro (Mestrado) Universidade de Coimbra Faculdade de Farmácia, Portugal
2023	master defense Orientador	Cristina Viseu Leote (Mestrado) Universidade de Coimbra, Portugal

Arbitragem científica em revista

	Nome da revista (ISSN)	Editora
2022/01/01 - Atual	Cell Biology (2330-0183)	Science Publishing Group
2016 - Atual	BIO-PROTOCOL (2331-8325)	Bio-Protocol
2025 - 2026	Biology
2022 - 2024	Bioprotocol

Curso / Disciplina lecionado

	Disciplina	Curso (Tipo)	Instituição / Organização
2020 - Atual	Molecular Biology	(Mestrado)	Universidade de Coimbra Faculdade de Medicina, Portugal
2023 - 2026	Desafios Societais – Saúde	(Licenciatura)	Universidade de Coimbra, Portugal
2020 - 2026	Practical classes of "Regulação Celular"	Regulac¸a~o Celular (Mestrado)	Universidade de Coimbra Faculdade de Medicina, Portugal

Membro de associação

	Nome da associação	Tipo de participação
2018 - Atual	International Society for Eye Research - ISER
2016 - Atual	Association for Research in Vision and Ophtalmology - ARVO
2015 - Atual	Association for Women in Science - AWIS
2013 - Atual	American Society for Cell Biology - ASCB

Membro de comissão

	Descrição da atividade Tipo de participação	Instituição / Organização
2016/01/15 - 2019/08/31	Chairman - The Biomedical Postdoctoral Council (BPC) is a volunteer organization run by and for postdocs. It strives to support all postdocs in their research training and career development and enhance their experiences on an academic, career development, social, political and cultural basis. The Foreign National Committee promotes training (orientation and immigration, taxes and visa seminars), networking events, relocation and social resources to welcome Foreign National postdocs to the University of Pennsylvania. Presidente / Vice-presidente	University of Pennsylvania School of Veterinary Medicine, Estados Unidos University of Pennsylvania Perelman School of Medicine, Estados Unidos
2013 - 2014	Co-founder - The Women Love Science Club goal is to inspire leadership and career development to women postdoctoral researchers and to provide a supportive network to help balancing personal, familial and professional life. Presidente / Vice-presidente	Fox Chase Cancer Center, Estados Unidos

Outro júri / avaliação

	Descrição da atividade	Instituição / Organização
2025/09 - 2026/02	Desafios Societais – Saúde	Universidade de Coimbra, Portugal
2025 - 2025	Fellowship jury	Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra, Portugal
2020 - 2025	Licenciatura internship evaluation of several bachelor students	Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra, Portugal
2023 - 2023	Fellowship jury	Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra, Portugal

Tutoria

	Tópico	Nome do aluno
2019/02/01 - Atual	Master student supervision	Ana Dias
2019 - Atual		Evelyn Santana
2025/12 - 2026/12	Deciphering the role of Ndr2 kinase player in the microglia-induced vascularisation in Diabetic Retinopathy	Carolina Santos
2025/09 - 2026/02	Medicina personalizada e de precisão: Do Rastreio Genómico aos Desafios Societais	Joana Moreira
2025/09 - 2026/02	Medicina personalizada e de precisão: Do Rastreio Genómico aos Desafios Societais	Keliane Semedo
2025/09 - 2026/02	Medicina personalizada e de precisão: Do Rastreio Genómico aos Desafios Societais	Miguel Ferreira
2021 - 2021		Diana Gonçalves
2021 - 2021		João Miguel Grácio
2020/01/01 - 2020/06/30		Caroline Veloso
2018 - 2019	Undergraduate Student mentoring	Clara Dannemann
2018 - 2019	Undergraduate Student mentoring	Deianara Huettenmoser
2018 - 2019	Undergraduate Student mentoring	Elisabeth Lemmon
2018 - 2019	Undergraduate Student mentoring	Faazal Rehman
2017 - 2017	Mouse handling - molecular biology	Rebecca Meltzer
2013 - 2013	Histology, Microscopy	Gene Han

Distinções

Prémio

2018	Travel Award University of Pennsylvania, Estados Unidos
2017	Travel Award University of Pennsylvania, Estados Unidos
2013	Postdoctoral Council Award Fox Chase Cancer Center, Estados Unidos
2008	Genopole Graduate Fellowship Genopole, França

Outra distinção

2019	Concurso Internacional
2017	Certification of Maître de Conférences Conseil National des Universités, França
2008	Selected for the Molecular biology of the cell course Institut Pasteur, França
2007	Exchange program between Paris-Sud and Montreal universities Université de Montréal, Canadá