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Identificação

Identificação pessoal

Nome completo
Sofia De Oliveira

Nomes de citação

  • Oliveira, Sofia

Identificadores de autor

Ciência ID
7011-768C-81B6
ORCID iD
0000-0003-0893-111X

Moradas

  • 1300 Morris Park Ave, Chanin Room 514, 10461, Bronx, New York, Estados Unidos (Profissional)

Websites

Domínios de atuação

  • Ciências Naturais - Ciências Biológicas - Biologia
  • Ciências Naturais - Ciências Biológicas - Biologia Celular
  • Ciências Naturais - Ciências Biológicas - Microbiologia
  • Ciências Médicas e da Saúde - Medicina Básica - Imunologia
  • Ciências Naturais - Ciências Biológicas - Bioquímica
  • Ciências Naturais - Ciências Biológicas - Biologia Molecular

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português (Idioma materno)
Inglês Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Espanhol; Castelhano Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C2) Utilizador proficiente (C1)
Francês Utilizador elementar (A1) Utilizador elementar (A1) Utilizador elementar (A1) Utilizador elementar (A1) Utilizador elementar (A1)
Formação
Grau Classificação
2014/09/12
Concluído
 Ciências Biomédicas (Doutoramento)
Especialização em Especialidade: Biologia Celular e Molecular
Universidade de Lisboa Faculdade de Medicina, Portugal
"HOW HYDROGEN PEROXIDE AND CXCL8 MODULATE NEUTROPHIL RECRUITMENT IN VIVO" (TESE/DISSERTAÇÃO)
 Unanimously with Honors and Distinction (maximum score)
2007/07/27
Concluído
 Bioquímica (Licenciatura)
Universidade de Coimbra, Portugal
"Modulation of erythrocyte deformability by PKC activity " (TESE/DISSERTAÇÃO)
 15
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2019/11 - Atual Investigador principal (carreira) (Investigação) Albert Einstein College of Medicine, Estados Unidos
2014/10 - 2019/10 Pós-doutorado (Investigação) University of Wisconsin-Madison, Estados Unidos
2014/05 - 2014/09 Estagiário de Investigação (Investigação) Consejería de Educación y Universidades de la Región de Murcia, Espanha
2007/09 - 2010/04 Estagiário de Investigação (Investigação) Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
2006/09/01 - 2007/07/30 Estagiário de Investigação (Investigação) Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Projetos

Bolsa

Designação Financiadores
2017/02 - 2019/10 The role of the innate immune system in hepatocarcinogenesis- FHL2 as a putative molecular target
n/a
Investigador Pós-doutorado
University of Wisconsin-Madison, Estados Unidos
 Cancer Research Institute
Concluído
2015/07 - 2017/01 In vivo study of the interaction between the transcriptional co-activator FHL2 and the actin cytoskeletal protein mAbp1 during invasive cell migration in Hepatocellular Carcinoma models.
EMBO ALTF 6202015
Investigador Pós-doutorado
EMBO Press
2010/05 - 2014/09 How Hydrogen Peroxide and CXCL8 modulate neutrophil recruitment in vivo
SFRH / BD / 62674 / 2009
Bolseiro de Doutoramento
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2007/10 - 2010/04 FIBRINOGEN-DEPENDENT SIGNALLING IN MICROVASCULAR BLOOD CELL FUNCTION - IMPLICATIONS OF INFLAMMATION AND CARDIOVASCULAR DISEASE.
PTDC/SAU-OSM/73449/2006
Bolseiro de Investigação
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído

Projeto

Designação Financiadores
2021/01 - 2023/12 Understanding neutrophil function in age-related immunometabolic dysfunction
n/a
Investigador responsável
Einstein Nathan Shock Center, Estados Unidos
 Einstein Nathan Shock Center
Em curso
2021/01 - 2023/12 The role of inflammation in the liver microenvironment of a Fibrolamellar Carcinoma zebrafish model.
n/a
Investigador responsável
The Andrew McDonough B+ Foundation, Estados Unidos
 The Andrew McDonough B+ Foundation
Em curso
2021/04 - 2023/03 Investigating the role of innate immune cells in the liver microenvironment during NASH progression.
n/a
Investigador responsável
Albert Einstein College of Medicine, Estados Unidos
 Marion Bessin Liver Research Center
Em curso
2014/10 - 2019/10 Adhesive regulation during cell migration
2R01CA085862-21A1
Investigador Pós-doutorado
University of Wisconsin-Madison, Estados Unidos
 Foundation for the National Institutes of Health
Concluído

Outro

Designação Financiadores
2019/11 - Atual Investigating how systemic chronic inflammation impacts the role of neutrophils in human disease progression
n/a
Investigador responsável
Albert Einstein College of Medicine, Estados Unidos
 Albert Einstein College of Medicine
Em curso
Produções

Publicações

Artigo em revista
  1. Samarpana Chakraborty; Lauren C. Shapiro; Sofia de Oliveira; Bianca Rivera-Pena; Amit Verma; Aditi Shastri. "Therapeutic targeting of the inflammasome in myeloid malignancies". Blood Cancer Journal (2021): https://doi.org/10.1038/s41408-021-00547-8.
    10.1038/s41408-021-00547-8
  2. Weinreb, Joshua T.; Ghazale, Noura; Pradhan, Kith; Gupta, Varun; Potts, Kathryn S.; Tricomi, Brad; Daniels, Noah J.; et al. "Excessive R-loops trigger an inflammatory cascade leading to increased HSPC production". Developmental Cell 56 5 (2021): 627-640.e5. http://dx.doi.org/10.1016/j.devcel.2021.02.006.
    10.1016/j.devcel.2021.02.006
  3. "Hydrogen peroxide in neutrophil inflammation: Lesson from the zebrafish". Developmental & Comparative Immunology (2020): http://dx.doi.org/10.1016/j.dci.2019.103583.
    10.1016/j.dci.2019.103583
  4. "DnaJ-PKAc fusion induces liver inflammation in a zebrafish model of Fibrolamellar Carcinoma". Disease Models & Mechanisms (2020): http://dx.doi.org/10.1242/dmm.042564.
    10.1242/dmm.042564
  5. "Metformin modulates innate immune-mediated inflammation and early progression of NAFLD-associated hepatocellular carcinoma in zebrafish". Journal of Hepatology (2019): http://dx.doi.org/10.1016/j.jhep.2018.11.034.
    10.1016/j.jhep.2018.11.034
  6. "Road map for fibrolamellar carcinoma: progress and goals of a diversified approach

    ". Journal of Hepatocellular Carcinoma (2019): http://dx.doi.org/10.2147/jhc.s194764.
    10.2147/jhc.s194764
  7. "Interleukin 8 mediates bcl-xL-induced enhancement of human melanoma cell dissemination and angiogenesis in a zebrafish xenograft model". International Journal of Cancer (2018): http://dx.doi.org/10.1002/ijc.31075.
    10.1002/ijc.31075
  8. "Mammalian Actin-binding Protein-1/Hip-55 Interacts with FHL2 and Negatively Regulates Cell Invasion". Journal of Biological Chemistry (2016): http://dx.doi.org/10.1074/jbc.m116.725739.
    10.1074/jbc.m116.725739
  9. "Neutrophil migration in infection and wound repair: going forward in reverse". Nature Reviews Immunology (2016): http://dx.doi.org/10.1038/nri.2016.49.
    10.1038/nri.2016.49
  10. "TRPV4-Mediated Detection of Hyposmotic Stress by Skin Keratinocytes Activates Developmental Immunity". The Journal of Immunology (2016): http://dx.doi.org/10.4049/jimmunol.1501729.
    10.4049/jimmunol.1501729
  11. "Md1 and Rp105 regulate innate immunity and viral resistance in zebrafish". Developmental & Comparative Immunology (2015): http://dx.doi.org/10.1016/j.dci.2015.01.005.
    10.1016/j.dci.2015.01.005
  12. "Cxcl8-l1 and Cxcl8-l2 are required in the zebrafish defense against Salmonella Typhimurium". Developmental & Comparative Immunology (2015): http://dx.doi.org/10.1016/j.dci.2014.11.004.
    10.1016/j.dci.2014.11.004
  13. "Duox1-Derived H2O2 Modulates Cxcl8 Expression and Neutrophil Recruitment via JNK/c-JUN/AP-1 Signaling and Chromatin Modifications". The Journal of Immunology (2015): http://dx.doi.org/10.4049/jimmunol.1402386.
    10.4049/jimmunol.1402386
  14. "ATP Modulates Acute Inflammation In Vivo through Dual Oxidase 1–Derived H2O2 Production and NF-¿B Activation". The Journal of Immunology (2014): http://dx.doi.org/10.4049/jimmunol.1302902.
    10.4049/jimmunol.1302902
  15. "Tnfa Signaling Through Tnfr2 Protects Skin Against Oxidative Stress–Induced Inflammation". PLoS Biology (2014): http://dx.doi.org/10.1371/journal.pbio.1001855.
    10.1371/journal.pbio.1001855
  16. "Cxcl8 (IL-8) Mediates Neutrophil Recruitment and Behavior in the Zebrafish Inflammatory Response". The Journal of Immunology (2013): http://dx.doi.org/10.4049/jimmunol.1203266.
    10.4049/jimmunol.1203266
  17. "Regulation of immunity and disease resistance by commensal microbes and chromatin modifications during zebrafish development". Proceedings of the National Academy of Sciences (2012): http://dx.doi.org/10.1073/pnas.1209920109.
    10.1073/pnas.1209920109
  18. "Integrin-associated protein (CD47) is a putative mediator for soluble fibrinogen interaction with human red blood cells membrane". Biochimica et Biophysica Acta (BBA) - Biomembranes (2012): http://dx.doi.org/10.1016/j.bbamem.2011.10.028.
    10.1016/j.bbamem.2011.10.028
  19. "Erythrocyte as a biological sensor". Clinical Hemorheology and Microcirculation (2012): http://doi.org/10.3233/CH-2011-1512.
    10.3233/CH-2011-1512
  20. "Variations on Fibrinogen-Erythrocyte Interactions during Cell Aging". PLoS ONE (2011): http://dx.doi.org/10.1371/journal.pone.0018167.
    10.1371/journal.pone.0018167
  21. "An overview about erythrocyte membrane". Clinical Hemorheology and Microcirculation (2010): http://doi.org/10.3233/CH-2010-1253.
    10.3233/CH-2010-1253
  22. "Modulation of erythrocyte deformability by PKC activity.". Clinical hemorheology and microcirculation (2008):

Outros

Outra produção
  1. Neutrophil reverse migration from liver fuels neutrophilic inflammation to tissue injury in Nonalcoholic Steatohepatitis. 2021. Maria Feliz-Norberto; Cassia Michael; Sofia de Oliveira. https://doi.org/10.1101/2021.10.03.462893.
    10.1101/2021.10.03.462893
  2. DNAJB1-PRKACA fusion induces liver inflammation in zebrafish model of Fibrolamellar Hepatocellular Carcinoma. DNAJB1-PRKACA fusion induces liver inflammation in zebrafish model of Fibrolamellar Hepatocellular Carcinoma. 2019. http://dx.doi.org/10.1101/781583.
    10.1101/781583
  3. High cholesterol diet modulates macrophage polarization and liver inflammation during early hepatocellular carcinoma progression in zebrafish. 2018. Sofia de Oliveira; Ruth A. Houseright; Alyssa L. Graves; Netta Golenberg; Benjamin G. Korte; Veronika Miskolci; Anna Huttenlocher. https://doi.org/10.1101/299016.
    10.1101/299016
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2021/11 Zebrafish: a powerful model to elucidate neutrophilic inflammatory response VII Simpósio O Zebrafish Como Modelo Animal de Pesquisa
Ives Charlie Silva (Brasil)
2021/10 Unveiling the impact of metainflammation in classic neutrophilic inflammatory response Zebrafish Disease Model 14
ZDMS (Durham)
2021/07 Using the zebrafish to understand the impact of diet-related metabolic disorder on neutrophil biology Webinar: Zebrafish as experimental model for research
Institute of Biomedical Sciences, University of Sau Paulo (Sau Paulo, Brasil)
2021/05 Using the zebrafish to understand the impact of the consumption of western-type diets in neutrophil biology Neutrophil 2021 Symposium
(Scotland, Reino Unido)
2020/09 Illuminating how cholesterol surplus impacts the inflammatory response with Zebrafish Seminar Dept of Infection, Immunity and Cardiovascular Disease
Phillip Elks and Stephen A Renshaw (Sheffield, Reino Unido)
2019/11 DNAJB1-PRKACA fusion induces liver inflammation in Fibrolamellar Hepatocellular Carcinoma 2019 Fibrolamellar Research Summit
Fibrolamelar Cancer Foundation (Stamford, Estados Unidos)
2019/01 Illuminating the impact of Western-type diets on inflammation with Zebrafish XII CICS-UBI - Seminar Cycle at CICS-UBI
Ana Paula Duarte (Covilha, Portugal)
2019/01 Illuminating the impact of Western-type diets on inflammation with Zebrafish Seminar Cycle Ciência Falada at ICVS-UM
Jorge Pedrosa (Braga, Portugal)
2018/12 “Illuminating the impact of Western-type diets on inflammation with Zebrafish” Seminar Champalimaud Foundation
Rita Fior (Lisboa, Portugal)
2018/12 Illuminating the impact of Western-type diets on inflammation with Zebrafish Satellite Seminar at i3S/Ipatimup
Manuel Sobrinho Simões and José Carlos Machado (Porto, Portugal)
2018/06 High cholesterol diet regulates macrophage polarization and early progression in a zebrafish model of NAFLD-associated HCC 13th International Zebrafish Conference
International Zebrafish Society (Madison, Estados Unidos)
2017/11 Zebrafish as a model to study Fibrolamellar Hepatocellular Carcinoma and other liver diseases 2017 Fibrolamellar Research Summit
Fibrolamelar Cancer Foundation (Stamford, Estados Unidos)
2017/11 The Effect of High Fat Diet in Hepatocellular Carcinoma Microenvironment - Illuminating Liver Diseases with Zebrafish. Seminar of Gastroenterology Department at Mayo Clinic
Mark McNiven Director of the Center for Biomedical Discovery, Mayo Clinic, Rochester (Rochester, Estados Unidos)
2013/11 Early ATP and Calcium signals modulate zebrafish acute inflammatory response via Duox 1 activation and hydrogen peroxide release Semmelweis Symposium 2013
(Budapest, Hungria)
2013/07 Early ATP and Calcium signals modulate zebrafish acute inflammatory response via Duox 1 activation and hydrogen peroxide release Zebrafish Disease Models 6
ZDMS (Murcia, Espanha)
2010/03 Binding of fibrinogen with RBCs of different biological ages: CD47, a possible molecular target 8th World Congress on Trauma, Shock, Inflammation and Trauma – TSIS 2010
(Munich, Alemanha)
2009/07 Fibrinogen and erythrocyte membrane interaction: potential binding sites evaluation 15th Conference of the European Society for Clinical Hemorheology and Microcirculation
(Pontresina, Suiça)

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação) 		Instituição / Organização
2012/07/14 - 2013/07/17 Help to organize Zebrafish Disease Model 6 in Murcia (Spain). Provided support to international participants during the meeting. Served as guide at social activities during the ZDM6 (2013/07/14 - 2013/07/17) Universidad de Murcia, Espanha

Júri de grau académico

Tema
Tipo de participação 		Nome do candidato (Tipo de grau)
Instituição / Organização
2021/12 AIF1L can limit susceptibility to HFD induced hyperphagia and weight gain
Arguente principal
 Dippal H Parikh (Doutoramento)
Albert Einstein College of Medicine, Estados Unidos

Comissão de avaliação

Descrição da atividade
Tipo de assessoria 		Instituição / Organização Entidade financiadora
2021 - Atual Student Award Committee. Evaluate and select students for different internal and external awards (i.e., HHMI Gilliam Fellowship, Regeneron, etc.) Albert Einstein College of Medicine, Estados Unidos
2020 - Atual Member of Qualifying Exam Steering Committee. Deliberate about policies regarding PhD candidate's examination at the end of the 2nd year that provides Master Degree. Chair Qualifying examinations and assure all guidelines are followed. Albert Einstein College of Medicine, Estados Unidos
2019/12 - Atual Member of the PhD Admission Committee. Screening, interviewing, evaluation and selection of candidates to EInstein PhD Program Albert Einstein College of Medicine, Estados Unidos

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2020 - Atual Mechanisms of Disease- Lecture on Neutrophils and zebrafish model (Doktor (PhD)) Albert Einstein College of Medicine, Estados Unidos

Entrevista (jornal / revista)

Descrição da atividade Jornal / Forum
2020 First Person is a series of interviews with the first authors of a selection of papers published in Disease Models & Mechanisms, helping early-career researchers promote themselves alongside their papers. Disease Models and Mechanisms

Membro de associação

Nome da associação Tipo de participação
2021 - Atual American Gastroenterology Society
2020 - Atual The Histochemical Society
2019 - Atual Zebrafish Disease Models Society Active member of Diversity, Inclusion and Equity Committee

Membro de comissão

Descrição da atividade
Tipo de participação 		Instituição / Organização
2021 - Atual Doctoral thesis Advisory Committee
Membro
 Fundação Champalimaud, Portugal
2020 - Atual Student Advisory Committee member (2 as a chair) of 5 PhD students
Membro
 Albert Einstein College of Medicine, Estados Unidos

Outro júri / avaliação

Descrição da atividade Instituição / Organização
2020 - Atual Qualifying Examination of PhD candidates. To evaluate that students have a general understanding of the biomedical sciences and sufficient knowledge of their chosen area of thesis research to proceed towards the PhD degree in a timely manner. Albert Einstein College of Medicine, Estados Unidos

Revisão ad hoc de artigos em revista

Nome da revista (ISSN) Editora
2021 - Atual Journal of Leukocyte Biology
2021 - Atual The International Journal of Biochemistry and Cell Biology
2021 - Atual OncoTargets and Therapy
2021 - Atual JCI Insight
2020 - Atual Frontiers in Cell and Developmental Biology
2020 - Atual Endocrine-Related Cancer
2020 - Atual Cancers
2020 - Atual Disease Mechanisms and Models
2019 - Atual Molecular Immunology
2018 - Atual Journal of Cellular Biochemistry
2018 - Atual International Journal of Biological Sciences
2017 - Atual Scientific Reports (2045-2322)

Tutoria

Tópico Nome do aluno
2022/03 - Atual Non Alcoholic Fatty Liver Disease and Neutrophils Mariana Abrantes do Amaral
2022 - Atual Polytrauma, Neutrophilic Inflammatory Response and Metainflammation Cassia Michael
2021/09 - Atual Sickle Cell Disease and Neutrophils Lidiane Torres
2021 - Atual Myeloid malignancies, Senescence and Systemic Inflammation Maria Feliz Norberto
2021 - Atual Non Alcoholic Fatty Liver Disease and Neutrophils Sammi Chung
2020 - Atual Liver cancer and Inflammation Francisco Juan Martinez Navarro
2021/08 - 2022/03 Non Alcoholic Fatty Liver Disease Irene PArdo Sanchez
2021/06 - 2021/09 Senescence and Systemic Inflammation David Silva Hernandez
2021/01 - 2021/03 Study of the impact of fructose on neutrophil wound response Kelsey Vinzent
2020/11 - 2021/01 Neutrophils and Autophagy Aneesa Valentine
2020/04 - 2020/06 Neutrophils and diet-induced trained immunity Alishba Maira
Distinções

Prémio

2013 Best Oral Presentation at Semmelweis Symposium 2013
2013 Best Oral Presentation Zebrafish Disease Models 6

Outra distinção

2016 Cancer Research Institute Postdoctoral fellowship.
2015 EMBO Long-term fellowship (ALTF 620-201)