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Identification

Personal identification

Full name
Sofia De Oliveira

Citation names

  • Oliveira, Sofia

Author identifiers

Ciência ID
7011-768C-81B6
ORCID iD
0000-0003-0893-111X

Addresses

  • 1300 Morris Park Ave, Chanin Room 514, 10461, Bronx, New York, United States (Professional)

Websites

Knowledge fields

  • Natural sciences - Biological Sciences - Biology
  • Natural sciences - Biological Sciences - Cell Biology
  • Natural sciences - Biological Sciences - Microbiology
  • Medical and Health Sciences - Basic Medicine - Immunology
  • Natural sciences - Biological Sciences - Biochemistry
  • Natural sciences - Biological Sciences - Molecular Biology

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Spanish; Castilian Advanced (C1) Advanced (C1) Advanced (C1) Proficiency (C2) Advanced (C1)
French Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
Education
Degree Classification
2014/09/12
Concluded
 Ciências Biomédicas (Doutoramento)
Major in Especialidade: Biologia Celular e Molecular
Universidade de Lisboa Faculdade de Medicina, Portugal
"HOW HYDROGEN PEROXIDE AND CXCL8 MODULATE NEUTROPHIL RECRUITMENT IN VIVO" (THESIS/DISSERTATION)
 Unanimously with Honors and Distinction (maximum score)
2007/07/27
Concluded
 Bioquímica (Licenciatura)
Universidade de Coimbra, Portugal
"Modulation of erythrocyte deformability by PKC activity " (THESIS/DISSERTATION)
 15
Affiliation

Science

Category
Host institution 		Employer
2019/11 - Current Principal Investigator (Research) Albert Einstein College of Medicine, United States
2014/10 - 2019/10 Postdoc (Research) University of Wisconsin-Madison, United States
2014/05 - 2014/09 Research Trainee (Research) Consejería de Educación y Universidades de la Región de Murcia, Spain
2007/09 - 2010/04 Research Trainee (Research) Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
2006/09/01 - 2007/07/30 Research Trainee (Research) Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Projects

Grant

Designation Funders
2017/02 - 2019/10 The role of the innate immune system in hepatocarcinogenesis- FHL2 as a putative molecular target
n/a
Post-doc
University of Wisconsin-Madison, United States
 Cancer Research Institute
Concluded
2015/07 - 2017/01 In vivo study of the interaction between the transcriptional co-activator FHL2 and the actin cytoskeletal protein mAbp1 during invasive cell migration in Hepatocellular Carcinoma models.
EMBO ALTF 6202015
Post-doc
EMBO Press
2010/05 - 2014/09 How Hydrogen Peroxide and CXCL8 modulate neutrophil recruitment in vivo
SFRH / BD / 62674 / 2009
PhD Student Fellow
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2007/10 - 2010/04 FIBRINOGEN-DEPENDENT SIGNALLING IN MICROVASCULAR BLOOD CELL FUNCTION - IMPLICATIONS OF INFLAMMATION AND CARDIOVASCULAR DISEASE.
PTDC/SAU-OSM/73449/2006
Research Fellow
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2021/01 - 2023/12 Understanding neutrophil function in age-related immunometabolic dysfunction
n/a
Principal investigator
Einstein Nathan Shock Center, United States
 Einstein Nathan Shock Center
Ongoing
2021/01 - 2023/12 The role of inflammation in the liver microenvironment of a Fibrolamellar Carcinoma zebrafish model.
n/a
Principal investigator
The Andrew McDonough B+ Foundation, United States
 The Andrew McDonough B+ Foundation
Ongoing
2021/04 - 2023/03 Investigating the role of innate immune cells in the liver microenvironment during NASH progression.
n/a
Principal investigator
Albert Einstein College of Medicine, United States
 Marion Bessin Liver Research Center
Ongoing
2014/10 - 2019/10 Adhesive regulation during cell migration
2R01CA085862-21A1
Post-doc
University of Wisconsin-Madison, United States
 Foundation for the National Institutes of Health
Concluded

Other

Designation Funders
2019/11 - Current Investigating how systemic chronic inflammation impacts the role of neutrophils in human disease progression
n/a
Principal investigator
Albert Einstein College of Medicine, United States
 Albert Einstein College of Medicine
Ongoing
Outputs

Publications

Journal article
  1. Samarpana Chakraborty; Lauren C. Shapiro; Sofia de Oliveira; Bianca Rivera-Pena; Amit Verma; Aditi Shastri. "Therapeutic targeting of the inflammasome in myeloid malignancies". Blood Cancer Journal (2021): https://doi.org/10.1038/s41408-021-00547-8.
    10.1038/s41408-021-00547-8
  2. Weinreb, Joshua T.; Ghazale, Noura; Pradhan, Kith; Gupta, Varun; Potts, Kathryn S.; Tricomi, Brad; Daniels, Noah J.; et al. "Excessive R-loops trigger an inflammatory cascade leading to increased HSPC production". Developmental Cell 56 5 (2021): 627-640.e5. http://dx.doi.org/10.1016/j.devcel.2021.02.006.
    10.1016/j.devcel.2021.02.006
  3. "Hydrogen peroxide in neutrophil inflammation: Lesson from the zebrafish". Developmental & Comparative Immunology (2020): http://dx.doi.org/10.1016/j.dci.2019.103583.
    10.1016/j.dci.2019.103583
  4. "DnaJ-PKAc fusion induces liver inflammation in a zebrafish model of Fibrolamellar Carcinoma". Disease Models & Mechanisms (2020): http://dx.doi.org/10.1242/dmm.042564.
    10.1242/dmm.042564
  5. "Metformin modulates innate immune-mediated inflammation and early progression of NAFLD-associated hepatocellular carcinoma in zebrafish". Journal of Hepatology (2019): http://dx.doi.org/10.1016/j.jhep.2018.11.034.
    10.1016/j.jhep.2018.11.034
  6. "Road map for fibrolamellar carcinoma: progress and goals of a diversified approach

    ". Journal of Hepatocellular Carcinoma (2019): http://dx.doi.org/10.2147/jhc.s194764.
    10.2147/jhc.s194764
  7. "Interleukin 8 mediates bcl-xL-induced enhancement of human melanoma cell dissemination and angiogenesis in a zebrafish xenograft model". International Journal of Cancer (2018): http://dx.doi.org/10.1002/ijc.31075.
    10.1002/ijc.31075
  8. "Mammalian Actin-binding Protein-1/Hip-55 Interacts with FHL2 and Negatively Regulates Cell Invasion". Journal of Biological Chemistry (2016): http://dx.doi.org/10.1074/jbc.m116.725739.
    10.1074/jbc.m116.725739
  9. "Neutrophil migration in infection and wound repair: going forward in reverse". Nature Reviews Immunology (2016): http://dx.doi.org/10.1038/nri.2016.49.
    10.1038/nri.2016.49
  10. "TRPV4-Mediated Detection of Hyposmotic Stress by Skin Keratinocytes Activates Developmental Immunity". The Journal of Immunology (2016): http://dx.doi.org/10.4049/jimmunol.1501729.
    10.4049/jimmunol.1501729
  11. "Md1 and Rp105 regulate innate immunity and viral resistance in zebrafish". Developmental & Comparative Immunology (2015): http://dx.doi.org/10.1016/j.dci.2015.01.005.
    10.1016/j.dci.2015.01.005
  12. "Cxcl8-l1 and Cxcl8-l2 are required in the zebrafish defense against Salmonella Typhimurium". Developmental & Comparative Immunology (2015): http://dx.doi.org/10.1016/j.dci.2014.11.004.
    10.1016/j.dci.2014.11.004
  13. "Duox1-Derived H2O2 Modulates Cxcl8 Expression and Neutrophil Recruitment via JNK/c-JUN/AP-1 Signaling and Chromatin Modifications". The Journal of Immunology (2015): http://dx.doi.org/10.4049/jimmunol.1402386.
    10.4049/jimmunol.1402386
  14. "ATP Modulates Acute Inflammation In Vivo through Dual Oxidase 1–Derived H2O2 Production and NF-¿B Activation". The Journal of Immunology (2014): http://dx.doi.org/10.4049/jimmunol.1302902.
    10.4049/jimmunol.1302902
  15. "Tnfa Signaling Through Tnfr2 Protects Skin Against Oxidative Stress–Induced Inflammation". PLoS Biology (2014): http://dx.doi.org/10.1371/journal.pbio.1001855.
    10.1371/journal.pbio.1001855
  16. "Cxcl8 (IL-8) Mediates Neutrophil Recruitment and Behavior in the Zebrafish Inflammatory Response". The Journal of Immunology (2013): http://dx.doi.org/10.4049/jimmunol.1203266.
    10.4049/jimmunol.1203266
  17. "Regulation of immunity and disease resistance by commensal microbes and chromatin modifications during zebrafish development". Proceedings of the National Academy of Sciences (2012): http://dx.doi.org/10.1073/pnas.1209920109.
    10.1073/pnas.1209920109
  18. "Integrin-associated protein (CD47) is a putative mediator for soluble fibrinogen interaction with human red blood cells membrane". Biochimica et Biophysica Acta (BBA) - Biomembranes (2012): http://dx.doi.org/10.1016/j.bbamem.2011.10.028.
    10.1016/j.bbamem.2011.10.028
  19. "Erythrocyte as a biological sensor". Clinical Hemorheology and Microcirculation (2012): http://doi.org/10.3233/CH-2011-1512.
    10.3233/CH-2011-1512
  20. "Variations on Fibrinogen-Erythrocyte Interactions during Cell Aging". PLoS ONE (2011): http://dx.doi.org/10.1371/journal.pone.0018167.
    10.1371/journal.pone.0018167
  21. "An overview about erythrocyte membrane". Clinical Hemorheology and Microcirculation (2010): http://doi.org/10.3233/CH-2010-1253.
    10.3233/CH-2010-1253
  22. "Modulation of erythrocyte deformability by PKC activity.". Clinical hemorheology and microcirculation (2008):

Other

Other output
  1. Neutrophil reverse migration from liver fuels neutrophilic inflammation to tissue injury in Nonalcoholic Steatohepatitis. 2021. Maria Feliz-Norberto; Cassia Michael; Sofia de Oliveira. https://doi.org/10.1101/2021.10.03.462893.
    10.1101/2021.10.03.462893
  2. DNAJB1-PRKACA fusion induces liver inflammation in zebrafish model of Fibrolamellar Hepatocellular Carcinoma. DNAJB1-PRKACA fusion induces liver inflammation in zebrafish model of Fibrolamellar Hepatocellular Carcinoma. 2019. http://dx.doi.org/10.1101/781583.
    10.1101/781583
  3. High cholesterol diet modulates macrophage polarization and liver inflammation during early hepatocellular carcinoma progression in zebrafish. 2018. Sofia de Oliveira; Ruth A. Houseright; Alyssa L. Graves; Netta Golenberg; Benjamin G. Korte; Veronika Miskolci; Anna Huttenlocher. https://doi.org/10.1101/299016.
    10.1101/299016
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2021/11 Zebrafish: a powerful model to elucidate neutrophilic inflammatory response VII Simpósio O Zebrafish Como Modelo Animal de Pesquisa
Ives Charlie Silva (Brazil)
2021/10 Unveiling the impact of metainflammation in classic neutrophilic inflammatory response Zebrafish Disease Model 14
ZDMS (Durham)
2021/07 Using the zebrafish to understand the impact of diet-related metabolic disorder on neutrophil biology Webinar: Zebrafish as experimental model for research
Institute of Biomedical Sciences, University of Sau Paulo (Sau Paulo, Brazil)
2021/05 Using the zebrafish to understand the impact of the consumption of western-type diets in neutrophil biology Neutrophil 2021 Symposium
(Scotland, United Kingdom)
2020/09 Illuminating how cholesterol surplus impacts the inflammatory response with Zebrafish Seminar Dept of Infection, Immunity and Cardiovascular Disease
Phillip Elks and Stephen A Renshaw (Sheffield, United Kingdom)
2019/11 DNAJB1-PRKACA fusion induces liver inflammation in Fibrolamellar Hepatocellular Carcinoma 2019 Fibrolamellar Research Summit
Fibrolamelar Cancer Foundation (Stamford, United States)
2019/01 Illuminating the impact of Western-type diets on inflammation with Zebrafish XII CICS-UBI - Seminar Cycle at CICS-UBI
Ana Paula Duarte (Covilha, Portugal)
2019/01 Illuminating the impact of Western-type diets on inflammation with Zebrafish Seminar Cycle Ciência Falada at ICVS-UM
Jorge Pedrosa (Braga, Portugal)
2018/12 “Illuminating the impact of Western-type diets on inflammation with Zebrafish” Seminar Champalimaud Foundation
Rita Fior (Lisboa, Portugal)
2018/12 Illuminating the impact of Western-type diets on inflammation with Zebrafish Satellite Seminar at i3S/Ipatimup
Manuel Sobrinho Simões and José Carlos Machado (Porto, Portugal)
2018/06 High cholesterol diet regulates macrophage polarization and early progression in a zebrafish model of NAFLD-associated HCC 13th International Zebrafish Conference
International Zebrafish Society (Madison, United States)
2017/11 Zebrafish as a model to study Fibrolamellar Hepatocellular Carcinoma and other liver diseases 2017 Fibrolamellar Research Summit
Fibrolamelar Cancer Foundation (Stamford, United States)
2017/11 The Effect of High Fat Diet in Hepatocellular Carcinoma Microenvironment - Illuminating Liver Diseases with Zebrafish. Seminar of Gastroenterology Department at Mayo Clinic
Mark McNiven Director of the Center for Biomedical Discovery, Mayo Clinic, Rochester (Rochester, United States)
2013/11 Early ATP and Calcium signals modulate zebrafish acute inflammatory response via Duox 1 activation and hydrogen peroxide release Semmelweis Symposium 2013
(Budapest, Hungary)
2013/07 Early ATP and Calcium signals modulate zebrafish acute inflammatory response via Duox 1 activation and hydrogen peroxide release Zebrafish Disease Models 6
ZDMS (Murcia, Spain)
2010/03 Binding of fibrinogen with RBCs of different biological ages: CD47, a possible molecular target 8th World Congress on Trauma, Shock, Inflammation and Trauma – TSIS 2010
(Munich, Germany)
2009/07 Fibrinogen and erythrocyte membrane interaction: potential binding sites evaluation 15th Conference of the European Society for Clinical Hemorheology and Microcirculation
(Pontresina, Switzerland)

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2012/07/14 - 2013/07/17 Help to organize Zebrafish Disease Model 6 in Murcia (Spain). Provided support to international participants during the meeting. Served as guide at social activities during the ZDM6 (2013/07/14 - 2013/07/17) Universidad de Murcia, Spain

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2021/12 AIF1L can limit susceptibility to HFD induced hyperphagia and weight gain
(Thesis) Main arguer
 Dippal H Parikh (PhD)
Albert Einstein College of Medicine, United States

Ad Hoc journal article review

Journal title (ISSN) Publisher
2021 - Current Journal of Leukocyte Biology
2021 - Current The International Journal of Biochemistry and Cell Biology
2021 - Current OncoTargets and Therapy
2021 - Current JCI Insight
2020 - Current Frontiers in Cell and Developmental Biology
2020 - Current Endocrine-Related Cancer
2020 - Current Cancers
2020 - Current Disease Mechanisms and Models
2019 - Current Molecular Immunology
2018 - Current Journal of Cellular Biochemistry
2018 - Current International Journal of Biological Sciences
2017 - Current Scientific Reports (2045-2322)

Association member

Society Organization name Role
2021 - Current American Gastroenterology Society
2020 - Current The Histochemical Society
2019 - Current Zebrafish Disease Models Society Active member of Diversity, Inclusion and Equity Committee

Committee member

Activity description
Role 		Institution / Organization
2021 - Current Doctoral thesis Advisory Committee
Member
 Fundação Champalimaud, Portugal
2020 - Current Student Advisory Committee member (2 as a chair) of 5 PhD students
Member
 Albert Einstein College of Medicine, United States

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2020 - Current Mechanisms of Disease- Lecture on Neutrophils and zebrafish model (Doktor (PhD)) Albert Einstein College of Medicine, United States

Evaluation committee

Activity description
Role 		Institution / Organization Funding entity
2021 - Current Student Award Committee. Evaluate and select students for different internal and external awards (i.e., HHMI Gilliam Fellowship, Regeneron, etc.) Albert Einstein College of Medicine, United States
2020 - Current Member of Qualifying Exam Steering Committee. Deliberate about policies regarding PhD candidate's examination at the end of the 2nd year that provides Master Degree. Chair Qualifying examinations and assure all guidelines are followed. Albert Einstein College of Medicine, United States
2019/12 - Current Member of the PhD Admission Committee. Screening, interviewing, evaluation and selection of candidates to EInstein PhD Program Albert Einstein College of Medicine, United States

Interview (newspaper / magazine)

Activity description Newspaper / Forum
2020 First Person is a series of interviews with the first authors of a selection of papers published in Disease Models & Mechanisms, helping early-career researchers promote themselves alongside their papers. Disease Models and Mechanisms

Mentoring / Tutoring

Topic Student name
2022/03 - Current Non Alcoholic Fatty Liver Disease and Neutrophils Mariana Abrantes do Amaral
2022 - Current Polytrauma, Neutrophilic Inflammatory Response and Metainflammation Cassia Michael
2021/09 - Current Sickle Cell Disease and Neutrophils Lidiane Torres
2021 - Current Myeloid malignancies, Senescence and Systemic Inflammation Maria Feliz Norberto
2021 - Current Non Alcoholic Fatty Liver Disease and Neutrophils Sammi Chung
2020 - Current Liver cancer and Inflammation Francisco Juan Martinez Navarro
2021/08 - 2022/03 Non Alcoholic Fatty Liver Disease Irene PArdo Sanchez
2021/06 - 2021/09 Senescence and Systemic Inflammation David Silva Hernandez
2021/01 - 2021/03 Study of the impact of fructose on neutrophil wound response Kelsey Vinzent
2020/11 - 2021/01 Neutrophils and Autophagy Aneesa Valentine
2020/04 - 2020/06 Neutrophils and diet-induced trained immunity Alishba Maira

Other jury / evaluation

Activity description Institution / Organization
2020 - Current Qualifying Examination of PhD candidates. To evaluate that students have a general understanding of the biomedical sciences and sufficient knowledge of their chosen area of thesis research to proceed towards the PhD degree in a timely manner. Albert Einstein College of Medicine, United States
Distinctions

Award

2013 Best Oral Presentation at Semmelweis Symposium 2013
2013 Best Oral Presentation Zebrafish Disease Models 6

Other distinction

2016 Cancer Research Institute Postdoctoral fellowship.
2015 EMBO Long-term fellowship (ALTF 620-201)