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Ana Patrícia Figueiredo Rocha Simões has published 16 articles in international Q1 scientific journals with peer-review (5 as a first author or co-first author and 1 as co-last author). Has an h-index of 13 and a total of 631 citations according to Scopus. Mentored several undergraduate students, including two Master students. Was an arguer of both Master and PhD dissertations and lectured in different Master programs from the Faculty of Science and Technology (MBCM; MBIOL; MBIOQ) and from the Faculty of Medicine (MIP; MIEBIOM; MIM) of the University of Coimbra and in the PhD program of CIBB (former CNC.IBILI) in Experimental Biology and Biomedicine. Works in the field of Medical and Health Sciences, in the subfield of Neuroscience. Her research focuses on the neurophysiology of purinergic receptors in the brain under normal and pathological conditions. In her curriculum Ciência Vitae the most frequent terms in the context of scientific and technological outputs are: purine receptors; P2 receptores; adenosine; fear; A2A receptors; Memory; PTSD; neuromodulation; neuroprotection.
Identificação

Identificação pessoal

Nome completo
Ana Patrícia Figueiredo Rocha Simões

Nomes de citação

  • Simões, Ana
  • Simões, AP
  • Simões, PF

Identificadores de autor

Ciência ID
6816-1D3F-D948
ORCID iD
0000-0003-2937-7015

Endereços de correio eletrónico

  • ana.simoes@uc.pt (Profissional)
  • anapatriciafrsimoes@gmail.com (Pessoal)

Telefones

Telefone
  • 239 820 19 Ext.: 125 (Profissional)

Moradas

  • Center for Neuroscience and Cell Biology, University of Coimbra, Rua Larga, Faculty of Medicine, Polo I, 1st floor, 3004-504 , Coimbra, Coimbra, Portugal (Profissional)
  • Praça Infante Dom Henrique, lote A 3E, 3030-055, Coimbra, Coimbra, Portugal (Pessoal)

Websites

Domínios de atuação

  • Ciências Médicas e da Saúde

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português (Idioma materno)
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Formação
Grau Classificação
2007/01/01 - 2012/04/27
Concluído
Ciências da Saúde (PhD in Health Sciences); grant from FCT (SFRH / BD / 32145 / 2006) (Doutoramento)
Especialização em Ciências Biomédicas (Biomedical sciences)
Universidade de Coimbra Faculdade de Medicina, Portugal
"Purinergic control of neuroinflammation and neuroprotection by the blockade of P2 receptors under excitotoxic conditions in the hippocampus" (TESE/DISSERTAÇÃO)
Distinção e Louvor (maximal)
1998/09/14 - 2003/09/22
Concluído
Bioquímica (Bachelor's degree in Biochemistry) (Licenciatura)
Universidade de Lisboa Faculdade de Ciências, Portugal
15 (0-20)
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento
Empregador
2019/02/01 - Atual Investigador (Investigação) Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
2013/02/01 - 2019/01/31 Pós-doutorado (Investigação) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2007/01/01 - 2012/04/27 Investigador (Investigação) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2006/02/01 - 2006/12/31 Assistente de Investigação (carreira) (Investigação) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2005/02/01 - 2005/12/31 Assistente de Investigação (carreira) (Investigação) Universidade de Coimbra Faculdade de Medicina, Portugal
2002/09 - 2003/11 Estagiário de Investigação (Investigação) Instituto de Biologia Experimental e Tecnológica, Portugal
Projetos

Bolsa

Designação Financiadores
2019/10 - Atual Adenosine A2A receptors as an opportunity to manage and detail the neurobiology of emotional distress
Fundacion La Caixa 2019
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Obra Social La Caixa
Em curso
2018/07 - Atual Adenosine A2A receptors as triggers of memory dysfunction in Alzheimer's disease: mechanisms and therapeutic prospects
PAS/31274
Bolseiro de Pós-Doutoramento
Comissão de Coordenação e Desenvolvimento Regional do Centro
Em curso
2016/05 - 2018/06 Role of astrocytes in the control of memory- focus on adenosine A2A receptors
PTDC/NEU-NMC/4154/2014
Bolseiro de Pós-Doutoramento
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2017 - 2018 Study of caffeine derivatives in the inhibition of Alzheimer's disease and as the basis to develop new therapeutics agents
Maratona da Saúde 2017
Bolseiro de Pós-Doutoramento
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2015/01 - 2017/06 The up-regulation of hippocampal adenosine A2A receptors is necessary and sufficient to trigger memory dysfunction in Alzheimer's disease
MB-98-2014
Bolseiro de Pós-Doutoramento
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Santa Casa da Misericórdia de Lisboa
Concluído
2014/09 - 2016/08 Role of adenosine A2A receptors in different brain circuits differently impact on reward and fear
NARSAD Independent Investigator Grant
Bolseiro de Pós-Doutoramento
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Brain and Behavior Research Foundation
Concluído
2014 - 2016 New treatments for stress-induced dysregulation of circuits regulating reward, fear and habit learning
DARPA-09-68-ESR-FP-010
Bolseiro de Pós-Doutoramento
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Defense Advanced Research Projects Agency
Concluído
2014 - 2015 Transcriptome, epigenome and proteome dysregulation in human circuits regulating reward, fear and habit learning
DARPA-BAA-10-55
Bolseiro de Pós-Doutoramento
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Defense Advanced Research Projects Agency
Concluído
2012/04 - 2014/09 Role of accumbens and amygdala in the control of chronic stress neuropathology
Bolseiro de Pós-Doutoramento
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2010/03 - 2012/09 Role of ATP and its P2Y1 receptors in neuroprotection
Bolseiro de Doutoramento
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2010/03 - 2012/02 Role of adenosine A2A receptors in microglia and glutamatergic synapses in the control of synaptic plasticity and brain damage
Bolseiro de Doutoramento
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2007/05 - 2010/04 Interaction between nicotine and caffeine in the striatum. Relevance for Parkinson´s disease
Bolseiro de Doutoramento
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2007/07 - 2009/10 Effect of purines in the developing hippocampus: consequences for the establishement of circuits related to learning and memory
Bolseiro de Doutoramento
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2007/06 - 2009/08 Role of extracellular ATP and characterization of purinergic receptors in the resistance of Candida albicans to macrophage attack
Bolseiro de Doutoramento
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
Produções

Publicações

Artigo em revista
  1. Simões, Ana; Portes, Marina; Silva, Henrique B.; Pliássova, Anna; Lourenço, Vanessa; Cunha, Rodrigo A.; Canas, Paula M.; Prediger, Rui D.. "Adenosine A2A receptots modulate generalization of contextual fear in rats.". Neuropharmacology (2022):
    Acesso aberto • Submetido
  2. Agostinho, Paula; Canas, Paula M.; Madeira, Daniela; Dias, Liliana; Simões, Ana; Cunha, Rodrigo A.. "Purinergic signaling orchestrating neuron-glia communication". Pharmacological Research 162 (2020): 105253.
    Publicado
  3. Reis, Sara L.; Silva, Henrique B.; Almeida, Margarida; Cunha, Rodrigo A.; Simões, Ana P.; Canas, Paula M.. "Adenosine A 1 and A 2A receptors differently control synaptic plasticity in the mouse dorsal and ventral hippocampus". Journal of Neurochemistry 151 2 (2019): 227-237. http://dx.doi.org/10.1111/jnc.14816.
    Publicado • 10.1111/jnc.14816
  4. Canas, Paula M.; Porciúncula, Lisiane O.; Simões, Ana Patrícia; Augusto, Elisabete; Silva, Henrique B.; Machado, Nuno J.; Gonçalves, Nélio; et al. "Neuronal Adenosine A2A Receptors Are Critical Mediators of Neurodegeneration Triggered by Convulsions". eneuro 5 6 (2018): ENEURO.0385-18.2018. http://dx.doi.org/10.1523/eneuro.0385-18.2018.
    Publicado • 10.1523/eneuro.0385-18.2018
  5. Real, Joana I.; Simões, Ana Patrícia; Cunha, Rodrigo A.; Ferreira, Samira G.; Rial, Daniel. "Adenosine A2A receptors modulate the dopamine D2 receptor-mediated inhibition of synaptic transmission in the mouse prefrontal cortex". European Journal of Neuroscience 47 9 (2018): 1127-1134. http://dx.doi.org/10.1111/ejn.13912.
    Publicado • 10.1111/ejn.13912
  6. Simões, Ana P.; Silva, Carla G.; Marques, Joana M.; Pochmann, Daniela; Porciúncula, Lisiane O.; Ferreira, Sofia; Oses, Jean P.; et al. "Glutamate-induced and NMDA receptor-mediated neurodegeneration entails P2Y1 receptor activation". Cell Death & Disease 9 3 (2018): 297. http://dx.doi.org/10.1038/s41419-018-0351-1.
    Publicado • 10.1038/s41419-018-0351-1
  7. Machado, Nuno J.; Simões, Ana Patrícia; Silva, Henrique B.; Ardais, Ana Paula; Kaster, Manuella P.; Garção, Pedro; Rodrigues, Diana I.; et al. "Caffeine Reverts Memory But Not Mood Impairment in a Depression-Prone Mouse Strain with Up-Regulated Adenosine A2A Receptor in Hippocampal Glutamate Synapses". Molecular Neurobiology 54 2 (2017): 1552-1563. http://dx.doi.org/10.1007/s12035-016-9774-9.
    Publicado • 10.1007/s12035-016-9774-9
  8. Simões, Ana Patrícia; Machado, Nuno J; Gonçalves, Nélio; Kaster, Manuella P; Simões, Ana T; Nunes, Ana; Pereira de Almeida, Luís; et al. "Adenosine A2A Receptors in the Amygdala Control Synaptic Plasticity and Contextual Fear Memory". Neuropsychopharmacology 41 12 (2016): 2862-2871. http://dx.doi.org/10.1038/npp.2016.98.
    Publicado • 10.1038/npp.2016.98
  9. Carmo, Marta R. S.; Simões, Ana Patrícia; Fonteles, Analu A.; Souza, Carolina M.; Cunha, Rodrigo A.; Andrade, Geanne M.. "ATP P2Y1 receptors control cognitive deficits and neurotoxicity but not glial modifications induced by brain ischemia in mice". European Journal of Neuroscience 39 4 (2014): 614-622. http://dx.doi.org/10.1111/ejn.12435.
    Publicado • 10.1111/ejn.12435
  10. Canas, Paula M.; Simões, Ana Patrícia; Rodrigues, Ricardo J.; Cunha, Rodrigo A.. "Predominant loss of glutamatergic terminal markers in a ß-amyloid peptide model of Alzheimer's disease". Neuropharmacology 76 (2014): 51-56. http://dx.doi.org/10.1016/j.neuropharm.2013.08.026.
    Publicado • 10.1016/j.neuropharm.2013.08.026
  11. Simões, Ana Patrícia; Duarte, João A; Agasse, Fabienne; Canas, Paula Margarida; Tomé, Angelo R; Agostinho, Paula; Cunha, Rodrigo A. "Blockade of adenosine A2A receptors prevents interleukin-1ß-induced exacerbation of neuronal toxicity through a p38 mitogen-activated protein kinase pathway". Journal of Neuroinflammation 9 1 (2012): 204. http://dx.doi.org/10.1186/1742-2094-9-204.
    Publicado • 10.1186/1742-2094-9-204
  12. Rebola, Nelson; Simões, Ana Patrícia; Canas, Paula M.; Tomé, Angelo R.; Andrade, Geanne M.; Barry, Claire E.; Agostinho, Paula M.; Lynch, Marina A.; Cunha, Rodrigo A.. "Adenosine A2A receptors control neuroinflammation and consequent hippocampal neuronal dysfunction". Journal of Neurochemistry 117 1 (2011): 100-111. http://dx.doi.org/10.1111/j.1471-4159.2011.07178.x.
    Publicado • 10.1111/j.1471-4159.2011.07178.x
  13. Quiroz, César; Luján, Rafael; Uchigashima, Motokazu; Simoes, Ana Patrícia; Lerner, Talia N.; Borycz, Janusz; Kachroo, Anil; et al. "Key Modulatory Role of Presynaptic Adenosine A2AReceptors in Cortical Neurotransmission to the Striatal Direct Pathway". The Scientific World JOURNAL 9 (2009): 1321-1344. http://dx.doi.org/10.1100/tsw.2009.143.
    Publicado • 10.1100/tsw.2009.143
  14. Gomes, Catarina A. R. V.; Simões, Patrícia F.; Canas, Paula M.; Quiroz, César; Sebastião, Ana M.; Ferré, Sergi; Cunha, Rodrigo A.; Ribeiro, Joaquim A.. "GDNF control of the glutamatergic cortico-striatal pathway requires tonic activation of adenosine A2A receptors". Journal of Neurochemistry 108 5 (2009): 1208-1219. http://dx.doi.org/10.1111/j.1471-4159.2009.05876.x.
    Publicado • 10.1111/j.1471-4159.2009.05876.x
  15. Simões, Patrícia F.; Silva, Ana P.; Pereira, Frederico C.; Marques, Elsa; Milhazes, Nuno; Borges, Fernanda; Ribeiro, Carlos F.; Macedo, Tice R.. "Methamphetamine Changes NMDA and AMPA Glutamate Receptor Subunit Levels in the Rat Striatum and Frontal Cortex". Annals of the New York Academy of Sciences 1139 1 (2008): 232-241. http://dx.doi.org/10.1196/annals.1432.028.
    Publicado • 10.1196/annals.1432.028
  16. Simões, P.F.; Silva, A.P.; Pereira, F.C.; Marques, E.; Grade, S.; Milhazes, N.; Borges, F.; Ribeiro, C.F.; Macedo, T.R.. "Methamphetamine induces alterations on hippocampal NMDA and AMPA receptor subunit levels and impairs spatial working memory". Neuroscience 150 2 (2007): 433-441. http://dx.doi.org/10.1016/j.neuroscience.2007.09.044.
    Publicado • 10.1016/j.neuroscience.2007.09.044
  17. Lopes, Maria de Fátima Silva; Simões, Ana Patrícia; Tenreiro, Rogério; Marques, José Joaquim Figueiredo; Crespo, Maria Teresa Barreto. "Activity and expression of a virulence factor, gelatinase, in dairy enterococci". International Journal of Food Microbiology 112 3 (2006): 208-214. http://dx.doi.org/10.1016/j.ijfoodmicro.2006.09.004.
    Publicado • 10.1016/j.ijfoodmicro.2006.09.004
Documento de trabalho
  1. Reis, Sara L.; Lourenço, Vanessa; Topilco, Tomak; Renier, Nicolas; Cunha, Rodrigo A.; Canas, Paula M.; Simões, Ana. 2021. "Adenosine A2A receptors at the ventral hippocampus and basolateral amygdala modulate contextual fear extinction".
  2. Simões, Ana; Gonçalves, Nélio; Lourenço, Vanessa; Gaspar, Ingride; Machado, Nuno J.; Souza, C.M.; Canas, Paula M.; et al. 2021. "Neuronal adenosine A2A receptors in the basolateral amygdala control chronic stress-induced pathophysiology".
  3. Gonçalves, Francisco; Rial, Daniel; Reis, Sara L.; Canas, Paula M.; Cunha, Rodrigo A.; Simões, Ana. Autor correspondente: Simões, Ana. 2021. "CD73-mediated formation of extracellular adenosine is responsible for adenosine A2A receptor-mediated control of fear memory and amygdala plasticity".
Poster em conferência
  1. Reis, Sara Cristina Lourenço dos; Lourenço, Vanessa; Cunha, Rodrigo A; Canas, Paula M.; Simões, Ana P.. Autor correspondente: Simões, Ana P.. "Adenosine A2A receptors control the extinction of fear memories". Trabalho apresentado em Annual Meeting of the Society for Neuroscience, Chicago, USA, 2019.
  2. Reis, Sara Cristina Lourenço dos; Lourenço, Vanessa; Cunha, Rodrigo A.; Canas, Paula M.; Simões, Ana. "Adenosine A2A receptors in the basolateral amygdala modulate fear extinction". Trabalho apresentado em XVI Meeting of the Portuguese Society for Neuroscience, 2019.
  3. Reis, Sara Cristina Lourenço dos; Silva, Henrique B.; Almeida, Margarida; Cunha, Rodrigo A.; Simões, Ana; Canas, Paula M.. "Adenosine A1 and A2A receptors play a different role in the dorsal and ventral hippocampus". Trabalho apresentado em 11th FENS Forum of Neuroscience, 2018.
  4. Reis, Sara L.; Silva, Henrique B.; Simões, Ana; Cunha, Rodrigo A.. "Different impact of the adenosinergic system in the dorsal versus ventral hippocampus". Trabalho apresentado em XV meeting of the Society for Neurosciences, 2017.
  5. Simões, Ana; Silva, Henrique B.; Reis, Sara L.; Cunha, Rodrigo A.. "ATP-derived adenosine activates A2A receptors controlling long-term potentiation in the amygdala". Trabalho apresentado em XV meeting of the Society for Neurosciences, 2017.
  6. Simões, Ana; Machado, Nuno J; Gonçalves, Nélio; Kaster, Manuella P; Simões, Ana T; Nunes, Ana; Pereira de Almeida, Luís; et al. "Adenosine A2A Receptors in the Amygdala control Synaptic Plasticity and Fear Memory". Trabalho apresentado em 7th International Society for Neurochemistry Special Conference of Neurochemistry, 2016.
  7. Simões, Ana; Gonçalves, Nélio; Rial, Daniel; Cunha, Rodrigo A.. "Amygdalar adenosine A2A receptors control synaptic plasticity and fear memory". Trabalho apresentado em XIV meeting of the Portuguese Society for Neurosciences, 2015.
  8. Simões, Ana; Gonçalves, Nélio; Rial, Daniel; Cunha, Rodrigo A.. "Adenosine A2A receptors in the amygdala control synaptic plasticity and conditional fear memory". Trabalho apresentado em XII annual meeting of the Center for Neuroscience and Cell Biology, 2014.
  9. Simões, Ana; Gonçalves, Nélio; Rial, Daniel; Cunha, Rodrigo A.. "Adenosine A2A receptors in the amygdala control synaptic plasticity and conditional fear memory". Trabalho apresentado em XLIV Annual Meeting of the Society for Neuroscience, 2014.
  10. Golçalves, Nélio; Machado, Nuno J.; Souza, C.M.; Simões, Ana; Cunha, Rodrigo A.. "The genetic deletion of adenosine A2A receptors selectively from amygdala neurons prevents mood-related modifications in rats subjected to repeated restraint stress". Trabalho apresentado em XLIV Annual Meeting of the Society for Neuroscience, 2014.
  11. Rodrigues, Ricardo J.; Simões, Ana; Silva, Carla G.; Pochmann, Daniela; Marques, Joana M.; Oses, J.P.; Beleza, Rui O.; Cunha, Rodrigo A.. "Neuronal P2Y1 receptors are required for NMDA-induced, calpain-mediated synaptic loss and neuronal death". Trabalho apresentado em 9th FENS forum of Neuroscience, 2014.
  12. Cunha, Rodrigo A.; Simões, Ana; Gonçalves, Nélio; Machado, Nuno J.; Kaster, Manuella P.; Nunes, Ana; Goosens, K.A.; Rial, Daniel. "Adenosine A2A receptors control fear responses and synaptic plasticity in the amygdala". Trabalho apresentado em 9th FENS forum of Neuroscience, 2014.
  13. Simões, Ana; Pochmann, Daniela; Tomé, Ângelo R.; Cunha, Rodrigo A.. "Blockade of P2Y1 receptors prevents microgliosis, neurodegeneration and the loss of synaptic markers in a kainate model of epilepsy". Trabalho apresentado em 8th FENS forum of Neuroscience, 2012.
  14. Simões, Ana; Silva, Carla G.; Duarte, João A.; Canas, Paula M.; Agostinho, Paula M.; Cunha, Rodrigo A.. "Involvement of the MAP Kinase pathway in the prevention by adenosine A2A receptors of IL1ß-induced neuronal toxicity". Trabalho apresentado em Sinal 2011- 5th annual meeting of Cell Signalling, 2011.
  15. Simões, Ana; Pochmann, Daniela; Cunha, Rodrigo A.. "P2 receptor antagonists differentially affect kainate- and NMDA- induced neurotoxicity in cultured hippocampal neurons". Trabalho apresentado em Society for Neuroscience, 2010.
  16. Simões, Ana; Pochmann, Daniela; Cunha, Rodrigo A.. "The P2 receptor antagonist PPADS differentially affects kainate- and NMDA-induced neurotoxicity in cultured hippocampal neurons". Trabalho apresentado em Purines 2010, 2010.
  17. Simões, Ana; Silva, Carla G.; Duarte, João A.; Canas, Paula M.. "Blockade of adenosine A2A receptors prevents the exacerbation of glutamate excitotoxicity by interleukin-1 beta in cultured hippocampal neurons". Trabalho apresentado em Purines 2010, 2010.
  18. Simões, Ana; Silva, Carla G.; Duarte, João D.; Canas, Paula M.; Cunha, Rodrigo A.. "Blockade of adenosine A2A receptors and ATP P2Y1 receptors prevents interleukin-1 beta associated neuronal toxicity". Trabalho apresentado em 11th meeting of Portuguese Society for Neurosciences, 2009.
  19. Simões, Ana; Silva, Carla G.; Duarte, João A.; Canas, Paula M.; Cunha, Rodrigo A.. "Blockade of adenosine A2A or P2Y1 receptors prevents interleukin-1Beta-mediated JNK phosphorylation in hippocampal neurons". Trabalho apresentado em Purines 2008, 2008.
  20. Simões, Ana; Cunha, Rodrigo A.. "Synaptic localization of ATP P2Y1 receptors in the adult rat striatum". Trabalho apresentado em Society for Neuroscience, 2007.
  21. Oses, J.P.; Simões, Ana; Canas, Paula M.; Rodrigues, Ricardo J.; Sarkis, J.J.F.; Oliveira, C.R.; Cunha, Rodrigo A.. "Modification by Kainate-induced convulsions of the density of presynaptic P2X receptors in the mouse hippocampus". Trabalho apresentado em 8th International Symposium on Adenosine and Adenine Nucleotides, 2006.
  22. Porciúncula, Lisiane O.; Rodrigues, Ricardo J.; Canas, Paula M.; Almeida, T.; Silva, Carla G.; Oses, J.P.; Simões, Ana; Oliveira, C.R.; Cunha, Rodrigo A.. "Presynaptic P2 receptors-Interaction with other receptors and role in Neuroprotection". Trabalho apresentado em 8th International Symposium on Adenosine and Adenine Nucleotides, 2006.
  23. Simões, Ana; Lopes, M.F.; Tenreiro, R.; Marques, J.J.; Crespo, M.T.. "Activity and Production of a Virulence Factor, Gelatinase, in Dairy Enterococci". Trabalho apresentado em Nacional congress of microbiology, 2003.
Tese / Dissertação
  1. Simões, Ana. "Adenosinergic control of fear extinction: the role of adenosine A2A receptors in the basolateral amygdala". Mestrado, Universidade de Coimbra Faculdade de Ciencias e Tecnologia, 2019. http://hdl.handle.net/10316/87955.
  2. Reis, Sara Cristina Lourenço dos. "CONTROL OF FEAR MEMORY BY ADENOSINE RECEPTORS: role in the physiology of the related brain circuitry and implications for fear extinction and post-traumatic stress disorder". Mestrado, Universidade de Coimbra Faculdade de Ciencias e Tecnologia, 2017. http://hdl.handle.net/10316/82884.
  3. Simões, Ana Patrícia Figueiredo Rocha. "Purinergic control of neuroinflammation and neuroprotection by the blockade of P2 receptors under excitotoxic conditions in the hippocampus". Doutoramento, Universidade de Coimbra Faculdade de Medicina, 2012. http://hdl.handle.net/10316/19898.
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2022/02/11 Astrocytic A2A receptors modulate hippocampal-dependent memory and synaptic plasticity Annual meeting of the Portuguese Society of Pharmacology
Portuguese Society of Pharmacology (Porto, Portugal)
2021/12/15 Adenosine A2A receptors in the amygdala are necessary and sufficient for the expression of mood dysfunction upon chronic stress Weekly seminars of the Coimbra Institute for Clinical and Biomedical Research (ICBR)
Institute for Clinical and Biomedical Research (ICBR) (Coimbra, Portugal)
2021/12/15 Adenosine A2A receptors in the amygdala are necessary and sufficient for the expression of mood dysfunction upon chronic stress Weekly seminars of the Coimbra Institute for Clinical and Biomedical Research (ICBR)
Coimbra Institute for Clinical and Biomedical Research (ICBR) (Coimbra, Portugal)
2021/12/03 Chronic over-function of adenosine A2A receptors in the basolateral amygdala mimics chronic stress phenotype
Portuguese Society for Neuroscience (Coimbra, Portugal)
2020/02/05 Optogenetic manipulation of adenosine A2A receptor-dependent pathways in the basolateral amygdala. L Annual meeting of the Portuguese Society of Pharmacology
Portuguese Society of Pharmacology (Coimbra, Portugal)
2020/02/05 Effect of astrocytic A2A receptors on hippocampal synaptic platicity and memory. L annual meeting of the Portuguese Society of Pharmacology
Portuguese Society of Pharmacology (Coimbra, Portugal)
2019/05/30 Adenosine A2A receptors control the extinction of fear memories. XVI Meeting of the Portuguese Society for Neuroscience
Portuguese Society for Neuroscience (Lisboa, Portugal)
2019/02/06 Adenosine A2A receptors in the basolateral amygdala modulate fear extinction XLIX annual reunion of the Portuguese Society of Pharmacology
Portuguese Society of Pharmacology (Porto, Portugal)
2019/02/06 Adenosine A2A receptors modulate the extinction of fear memories XLIX annual reunion of the Portuguese Society of Pharmacology
Portuguese Society of Pharmacology (Porto, Portugal)
2018/02/05 Adenosine A1 and A2A receptors play a different role in the dorsal and ventral hippocampus. XLVIII annual reunion of the Portuguese Society of Pharmacology
Portuguese Society of Pharmacology (Lisboa, Portugal)
2017/02/02 Overexpression of adenosine A1 receptors decreases cognitive flexibility and long-term potentiation in the mouse brain. XLVII annual reunion of the Portuguese Society of Pharmacology
Portuguese Society of Pharmacology (Coimbra, Portugal)
2017/02/02 ATP-derived adenosine activates A2A receptors controlling long-term potentiation in the amygdala. XLVII annual reunion of the Portuguese Society of Pharmacology
Portuguese Society of Pharmacology (Coimbra, Portugal)
2017/02/02 Selective down-regulation of amygdala neuronal A2A receptors prevents behavioral modifications induced by stress XLVII annual reunion of the Portuguese Society of Pharmacology
Portuguese Society of Pharmacology (Coimbra, Portugal)
2015/06/04 The triad of behavioural modifications characteristic of depression is abrogated by the selective amygdala neuronal down-regulation of adenosine A2A receptors. XIV meeting of the Portuguese Society for Neurosciences
Portuguese Society for Neurosciences (Póvoa do Varzim, Portugal)
2015/02/05 Adenosine A2A receptors selectively modulate long-term plasticity in the amygdala of mice and control fear memory XLV annual meeting of the Portuguese Society of Pharmacology
Portuguese Society of Pharmacology (Lisboa, Portugal)
2014/02/05 Role of adenosine A2A receptors in the amygdala: implications for chronic stress. XLIV annual meeting of the Portuguese Society of Pharmacology
Portuguese Society of Pharmacology (Coimbra, Portugal)
2013/06/30 Adenosine A2A receptors control plasticity in amygdalar circuits. XIII meeting of the Portuguese Society for Neuroscience
Portuguese Society for Neuroscience (Luso, Portugal)
2011/02/02 ATP P2 receptor antagonists prevent neuronal damage. XLI Annual Meeting of the Portuguese Society of Pharmacology
Portuguese Society of Pharmacology (Coimbra, Portugal)
2009/12/16 Blockade of adenosine A2A receptors prevents IL1ß associated neuronal toxicity. Annual Meeting of the Center for Neuroscience and Cell Biology
Center for Neuroscience and Cell Biology (Cantanhede, Portugal)
2009/12/02 Blockade of adenosine A2A receptors prevents IL1ß associated neuronal toxicity. XL Annual Meeting of the Portuguese Society of Pharmacology
Portuguese Society of Pharmacology (Porto, Portugal)
2008/12/03 Effect of adenosine A2A and ATP P2Y1 receptors blockade on pro-inflammatory mediated neurotoxicity in neurons XXXIX Annual Meeting of the Portuguese Society of Pharmacology
Portuguese Society of Pharmacology (Lisboa, Portugal)
2006/12/05 Methamphetamine alters NMDA and AMPA receptor subunit densities in the rat brain. XXXVlI Annual Meeting of the Portuguese Society of Pharmacology
Portuguese Society of Pharmacology (Porto, Portugal)
2005/12/05 Effect of subchronic and acute methamphetamine administration on the expression of ionotropic glutamate receptors in the rat hippocampus. XXXVl Annual Meeting of the Portuguese Society of Pharmacology
Portuguese Society of Pharmacology (Lisboa, Portugal)

Orientação

Título / Tema
Papel desempenhado
Curso (Tipo)
Instituição / Organização
2021/09/01 - 2022/07/31 Impact of chronic stress on A2A receptors control of amygdala function
Orientador de Ingride Luzio Gaspar
Master in Cellular and Molecular Biology
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2018/09 - 2019/07/24 Adenosinergic control of fear extinction: the role of adenosine A2A receptors in the basolateral amygdala
Orientador de Vanessa Simões Lourenço
Master in Molecular and Cellular Biology (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2016/09 - 2017/07/19 Control of fear memory by adenosine receptors: role in the physiology of the related brain circuitry and implications for fear extinction and post-traumatic stress disorder
Orientador de Sara Cristina Lourenço dos Reis
Master in Cellular and Molecular Biology (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Participação em evento

Descrição da atividade
Tipo de evento
Nome do evento
Instituição / Organização
2021/05/24 - 2021/05/24 Oral presentation titled "A2A receptors in the amygdala are necessary and sufficient for the expression of mood dysfunction upon chronic stress"
Seminário
3rd CIBB Neuroscience and Disease Retreat
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2019/05/10 - 2019/05/10 Oral presentation titled "Extinction of fear memories: a role for adenosine A2A receptors".
Seminário
Retreat of the area 'Neuroscience and Disease' of the Center for Innovation in Biomedicine and Biotechnology
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2016/10/28 - 2016/10/28 Oral presentation titled "Targeting adenosine A2A receptors in the amygdala: implications for fear memory and mood disorders".
Seminário
Seminar presented at the 'weekly seminars of the Center for Neuroscience and Cell Biology'
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Júri de grau académico

Tema
Tipo de participação
Nome do candidato (Tipo de grau)
Instituição / Organização
2021/12/10 NT3/TrkC intracellular signaling in the processing of fear
Arguente principal
Francisca Gonçalo da Silva (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2017/07/10 Role of epinephrine in fear memory
Arguente
Ester Sofia Pereira dos Santos Alves (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2016/09/07 Developing assays to assess structure and function of synapses in vitro
Arguente principal
João Francisco Chibeles Rebelo Pestana Baptista (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Arbitragem científica em revista

Nome da revista (ISSN) Editora
2021/08/04 - 2022/08/31 JoVE (1940-087X)
2021/04/04 - 2022/03/15 Frontiers in Neuronal Circuits (16625110)

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2021/05/04 - Atual Ageing as a risk factor for brain diseases: senolytics. Neuropharmacology (Mestrado integrado) Universidade de Coimbra Faculdade de Medicina, Portugal
2022/04/19 - 2022/04/19 Fear, panic and PTSD: therapeutic perspectives. Neuropharmacology (Mestrado integrado) Universidade de Coimbra Faculdade de Medicina, Portugal
2021/12/05 - 2021/12/05 The amygdala: learning through emotions. (Mestrado) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2021/11/25 - 2021/11/25 Stress from a synaptic perspective. (Mestrado integrado) Universidade de Coimbra Faculdade de Medicina, Portugal
2021/11/24 - 2021/11/24 Fear memory acquisition and extinction. (Mestrado integrado) Universidade de Coimbra Faculdade de Medicina, Portugal
2021/11/17 - 2021/11/17 Electrophysiology: extracellular and patch clamp recordings. Tecnologias de Investigação em Neurobiologia (Mestrado integrado) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2021/05/04 - 2021/05/04 Medo, pânico e stress pós-traumático: perspectivas de intervenção terapêutica. Neurofarmacologia (Mestrado) Universidade de Coimbra Faculdade de Medicina, Portugal
2021/01/13 - 2021/01/13 Fear memory acquisition and extinction. Neurofisiologia e cognição (Mestrado) Universidade de Coimbra Faculdade de Medicina, Portugal
2020/12/09 - 2020/12/09 The amygdala: learning through emotions. (Mestrado) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2019/12/05 - 2019/12/05 Neuronal Circuits and Behaviour: The amygdala: learning through emotions. Circuitos Neuronais e Comportamento (Mestrado) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2019/11/29 - 2019/11/29 Biology and Physiology of Ageing: Perspectives on the control of senescence with ageing- senolytics. Biologia e Fisiologia do Envelhecimento (Mestrado integrado) Universidade de Coimbra Faculdade de Medicina, Portugal
2019/11/14 - 2019/11/14 Biology and Physiology of Ageing: Diet and ageing. Biologia e Fisiologia do Envelhecimento (Mestrado integrado) Universidade de Coimbra Faculdade de Medicina, Portugal
2019/10/31 - 2019/10/31 Technologies for Research in Neurobiology: Introduction to elecrophysiology. Tecnologias de Investigação em Neurobiologia (Mestrado integrado) Universidade de Coimbra Faculdade de Medicina, Portugal
2019/04/04 - 2019/04/04 Cellular and Molecular fundaments of Ageing: Inflammation and ageing. Fundamentos Moleculares and Celulares do Envelhecimento Universidade de Coimbra Faculdade de Medicina, Portugal
2019/03/27 - 2019/03/27 Neuropharmacology: fear, panic and post-traumatic stress- perspectives on therapeutic interventions Neurofarmacologia (Mestrado) Universidade de Coimbra Faculdade de Medicina, Portugal
2018/12/10 - 2018/12/10 Neuronal Circuits and Behaviour: The amygdala- learning through emotions. Circuitos Neuronais e Comportamento (Mestrado) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2018/11/30 - 2018/11/30 Biology and Physiology of Ageing: Theories of systems controlling ageing; neuro-endocrine modifications; loss of mechanisms of homeostatic control. Biologia e Fisiologia do Envelhecimento (Mestrado integrado) Universidade de Coimbra Faculdade de Medicina, Portugal
2018/11/22 - 2018/11/22 Biology and Physiology of Ageing: Diet and ageing; prevention of cognitive and emotional decline with moderate caffeine consumption. Biologia e Fisiologia do Envelhecimento (Mestrado integrado) Universidade de Coimbra Faculdade de Medicina, Portugal
2018/11/15 - 2018/11/15 Biology and Physiology of Ageing: Mitochondrial theories of ageing; ageing and bioenergetics. Biologia e Fisiologia do Envelhecimento (Mestrado integrado) Universidade de Coimbra Faculdade de Medicina, Portugal
2017/11/30 - 2017/11/30 Biology of Drug Abuse: Behavioural evaluation in Neuroscience using rodent models Biologia do Abuso de Drogas (Mestrado) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Tutoria

Tópico Nome do aluno
2022/03/02 - 2022/04/11 Dissecting the role of caffeine and adenosine A2A receptors in the control of mood dysfunction Maria Inês Esteves
2022/02/07 - 2022/02/28 Impact of chronic stress on A2A receptors control of amygdala function Madalena Piteira
2018/05/14 - 2018/06/08 Adenosinergic modulation of fear extinction: focus on the role of A1 and A2A receptors in the amygdala Ana Moreira de Sá
2017/05/01 - 2017/06/30 Evaluation of the adenosinergic system in a model of intrauterine ischaemia Jorge Miguel Santos Castanheira
2016/02/08 - 2016/07/29 Impact of A2A Receptors in the sensory thalamus-amygdala pathway: relevance for fear acquisition and extinction Juliana Silva
2014/06/16 - 2014/07/04 Downregulation of adenosine A2A receptors from the basolateral amygdala: impact on chronic stress Tiago Campelo
2009/03/01 - 2009/04/01 Effect of pro-inflamatory cytokine IL-1ß on glutamate-induced excitotoxicity on hippocampal neurons Marta Santos Esteves da Silva
Distinções

Prémio

2015 Best Poster
Sociedade Portuguesa de Neurociências, Portugal
2014 Best Poster
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Outra distinção

2021 Scholarship
Sociedade Portuguesa de Neurociências, Portugal
2017 Scholarship
Sociedade Portuguesa de Neurociências, Portugal
2012 Post Doc grant (SFRH/BPD/91683/2012)
Fundação para a Ciência e a Tecnologia, Portugal
2006 PhD grant (SFRH/BD/32145/2006)
Fundação para a Ciência e a Tecnologia, Portugal