Curriculum Vitae
Ana Patrícia Figueiredo Rocha Simões
Identification
Personal identification
- Full name
- Ana Patrícia Figueiredo Rocha Simões
Citation names
- Simões, Ana
- Simões, AP
- Simões, PF
Author identifiers
- Ciência ID
- 6816-1D3F-D948
- ORCID iD
- 0000-0003-2937-7015
Email addresses
- ana.simoes@uc.pt (Professional)
- anapatriciafrsimoes@gmail.com (Personal)
Telephones
- Telephone
-
- 239 820 19 Ext.: 125 (Professional)
Addresses
- Center for Neuroscience and Cell Biology, University of Coimbra, Rua Larga, Faculty of Medicine, Polo I, 1st floor, 3004-504 , Coimbra, Coimbra, Portugal (Professional)
- Praça Infante Dom Henrique, lote A 3E, 3030-055, Coimbra, Coimbra, Portugal (Personal)
Websites
- http://www.cibb.uc.pt (Professional)
Knowledge fields
- Medical and Health Sciences
Languages
| Language | Speaking | Reading | Writing | Listening | Peer-review |
|---|---|---|---|---|---|
| Portuguese (Mother tongue) | |||||
| English | Advanced (C1) | Advanced (C1) | Advanced (C1) | Advanced (C1) | Advanced (C1) |
Education
| Degree | Classification | |
|---|---|---|
|
2007/01/01 - 2012/04/27
Concluded
|
Ciências da Saúde (PhD in Health Sciences); grant from FCT (SFRH / BD / 32145 / 2006) (Doutoramento)
Major in Ciências Biomédicas (Biomedical sciences)
Universidade de Coimbra Faculdade de Medicina, Portugal
"Purinergic control of neuroinflammation and neuroprotection by the blockade of P2 receptors under excitotoxic conditions
in the hippocampus" (THESIS/DISSERTATION)
|
Distinção e Louvor (maximal) |
|
1998/09/14 - 2003/09/22
Concluded
|
Bioquímica (Bachelor's degree in Biochemistry) (Licenciatura)
Universidade de Lisboa Faculdade de Ciências, Portugal
|
15 (0-20) |
Affiliation
Science
| Category Host institution |
Employer | |
|---|---|---|
| 2019/02/01 - Current | Researcher (Research) | Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal |
| 2013/02/01 - 2019/01/31 | Postdoc (Research) | Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal |
| 2007/01/01 - 2012/04/27 | Researcher (Research) | Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal |
| 2006/02/01 - 2006/12/31 | Research Assistant (Research) | Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal |
| 2005/02/01 - 2005/12/31 | Research Assistant (Research) | Universidade de Coimbra Faculdade de Medicina, Portugal |
| 2002/09 - 2003/11 | Research Trainee (Research) | Instituto de Biologia Experimental e Tecnológica, Portugal |
Projects
Grant
| Designation | Funders | |
|---|---|---|
| 2019/10 - Current | Adenosine A2A receptors as an opportunity to manage and detail the neurobiology of emotional distress
Fundacion La Caixa 2019
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
|
Obra Social La Caixa
Ongoing
|
| 2018/07 - Current | Adenosine A2A receptors as triggers of memory dysfunction in Alzheimer's disease: mechanisms and therapeutic prospects
PAS/31274
Post-doc Fellow
|
Comissão de Coordenação e Desenvolvimento Regional do Centro
Ongoing
|
| 2016/05 - 2018/06 | Role of astrocytes in the control of memory- focus on adenosine A2A receptors
PTDC/NEU-NMC/4154/2014
Post-doc Fellow
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
|
Fundação para a Ciência e a Tecnologia
Concluded
|
| 2017 - 2018 | Study of caffeine derivatives in the inhibition of Alzheimer's disease and as the basis to develop new therapeutics agents
Maratona da Saúde 2017
Post-doc Fellow
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
|
Fundação para a Ciência e a Tecnologia
Concluded
|
| 2015/01 - 2017/06 | The up-regulation of hippocampal adenosine A2A receptors is necessary and sufficient to trigger memory dysfunction in Alzheimer's
disease
MB-98-2014
Post-doc Fellow
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
|
Santa Casa da Misericórdia de Lisboa
Concluded
|
| 2014/09 - 2016/08 | Role of adenosine A2A receptors in different brain circuits differently impact on reward and fear
NARSAD Independent Investigator Grant
Post-doc Fellow
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
|
Brain and Behavior Research Foundation
Concluded
|
| 2014 - 2016 | New treatments for stress-induced dysregulation of circuits regulating reward, fear and habit learning
DARPA-09-68-ESR-FP-010
Post-doc Fellow
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
|
Defense Advanced Research Projects Agency
Concluded
|
| 2014 - 2015 | Transcriptome, epigenome and proteome dysregulation in human circuits regulating reward, fear and habit learning
DARPA-BAA-10-55
Post-doc Fellow
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
|
Defense Advanced Research Projects Agency
Concluded
|
| 2012/04 - 2014/09 | Role of accumbens and amygdala in the control of chronic stress neuropathology
Post-doc Fellow
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
|
Fundação para a Ciência e a Tecnologia
Concluded
|
| 2010/03 - 2012/09 | Role of ATP and its P2Y1 receptors in neuroprotection
PhD Student Fellow
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
|
Fundação para a Ciência e a Tecnologia
Concluded
|
| 2010/03 - 2012/02 | Role of adenosine A2A receptors in microglia and glutamatergic synapses in the control of synaptic plasticity and brain damage
PhD Student Fellow
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
|
Fundação para a Ciência e a Tecnologia
Concluded
|
| 2007/05 - 2010/04 | Interaction between nicotine and caffeine in the striatum. Relevance for Parkinson´s disease
PhD Student Fellow
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
|
Fundação para a Ciência e a Tecnologia
Concluded
|
| 2007/07 - 2009/10 | Effect of purines in the developing hippocampus: consequences for the establishement of circuits related to learning and memory
PhD Student Fellow
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
|
Fundação para a Ciência e a Tecnologia
Concluded
|
| 2007/06 - 2009/08 | Role of extracellular ATP and characterization of purinergic receptors in the resistance of Candida albicans to macrophage
attack
PhD Student Fellow
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
|
Fundação para a Ciência e a Tecnologia
Concluded
|
Outputs
Publications
| Conference poster |
|
| Journal article |
|
| Thesis / Dissertation |
|
| Working paper |
|
Activities
Oral presentation
| Presentation title | Event name Host (Event location) |
|
|---|---|---|
| 2022/02/11 | Astrocytic A2A receptors modulate hippocampal-dependent memory and synaptic plasticity | Annual meeting of the Portuguese Society of Pharmacology
Portuguese Society of Pharmacology (Porto, Portugal)
|
| 2021/12/15 | Adenosine A2A receptors in the amygdala are necessary and sufficient for the expression of mood dysfunction upon chronic stress | Weekly seminars of the Coimbra Institute for Clinical and Biomedical Research (ICBR)
Institute for Clinical and Biomedical Research (ICBR) (Coimbra, Portugal)
|
| 2021/12/15 | Adenosine A2A receptors in the amygdala are necessary and sufficient for the expression of mood dysfunction upon chronic stress | Weekly seminars of the Coimbra Institute for Clinical and Biomedical Research (ICBR)
Coimbra Institute for Clinical and Biomedical Research (ICBR) (Coimbra, Portugal)
|
| 2021/12/03 | Chronic over-function of adenosine A2A receptors in the basolateral amygdala mimics chronic stress phenotype |
Portuguese Society for Neuroscience (Coimbra, Portugal)
|
| 2020/02/05 | Optogenetic manipulation of adenosine A2A receptor-dependent pathways in the basolateral amygdala. | L Annual meeting of the Portuguese Society of Pharmacology
Portuguese Society of Pharmacology (Coimbra, Portugal)
|
| 2020/02/05 | Effect of astrocytic A2A receptors on hippocampal synaptic platicity and memory. | L annual meeting of the Portuguese Society of Pharmacology
Portuguese Society of Pharmacology (Coimbra, Portugal)
|
| 2019/05/30 | Adenosine A2A receptors control the extinction of fear memories. | XVI Meeting of the Portuguese Society for Neuroscience
Portuguese Society for Neuroscience (Lisboa, Portugal)
|
| 2019/02/06 | Adenosine A2A receptors in the basolateral amygdala modulate fear extinction | XLIX annual reunion of the Portuguese Society of Pharmacology
Portuguese Society of Pharmacology (Porto, Portugal)
|
| 2019/02/06 | Adenosine A2A receptors modulate the extinction of fear memories | XLIX annual reunion of the Portuguese Society of Pharmacology
Portuguese Society of Pharmacology (Porto, Portugal)
|
| 2018/02/05 | Adenosine A1 and A2A receptors play a different role in the dorsal and ventral hippocampus. | XLVIII annual reunion of the Portuguese Society of Pharmacology
Portuguese Society of Pharmacology (Lisboa, Portugal)
|
| 2017/02/02 | Overexpression of adenosine A1 receptors decreases cognitive flexibility and long-term potentiation in the mouse brain. | XLVII annual reunion of the Portuguese Society of Pharmacology
Portuguese Society of Pharmacology (Coimbra, Portugal)
|
| 2017/02/02 | ATP-derived adenosine activates A2A receptors controlling long-term potentiation in the amygdala. | XLVII annual reunion of the Portuguese Society of Pharmacology
Portuguese Society of Pharmacology (Coimbra, Portugal)
|
| 2017/02/02 | Selective down-regulation of amygdala neuronal A2A receptors prevents behavioral modifications induced by stress | XLVII annual reunion of the Portuguese Society of Pharmacology
Portuguese Society of Pharmacology (Coimbra, Portugal)
|
| 2015/06/04 | The triad of behavioural modifications characteristic of depression is abrogated by the selective amygdala neuronal down-regulation of adenosine A2A receptors. | XIV meeting of the Portuguese Society for Neurosciences
Portuguese Society for Neurosciences (Póvoa do Varzim, Portugal)
|
| 2015/02/05 | Adenosine A2A receptors selectively modulate long-term plasticity in the amygdala of mice and control fear memory | XLV annual meeting of the Portuguese Society of Pharmacology
Portuguese Society of Pharmacology (Lisboa, Portugal)
|
| 2014/02/05 | Role of adenosine A2A receptors in the amygdala: implications for chronic stress. | XLIV annual meeting of the Portuguese Society of Pharmacology
Portuguese Society of Pharmacology (Coimbra, Portugal)
|
| 2013/06/30 | Adenosine A2A receptors control plasticity in amygdalar circuits. | XIII meeting of the Portuguese Society for Neuroscience
Portuguese Society for Neuroscience (Luso, Portugal)
|
| 2011/02/02 | ATP P2 receptor antagonists prevent neuronal damage. | XLI Annual Meeting of the Portuguese Society of Pharmacology
Portuguese Society of Pharmacology (Coimbra, Portugal)
|
| 2009/12/16 | Blockade of adenosine A2A receptors prevents IL1ß associated neuronal toxicity. | Annual Meeting of the Center for Neuroscience and Cell Biology
Center for Neuroscience and Cell Biology (Cantanhede, Portugal)
|
| 2009/12/02 | Blockade of adenosine A2A receptors prevents IL1ß associated neuronal toxicity. | XL Annual Meeting of the Portuguese Society of Pharmacology
Portuguese Society of Pharmacology (Porto, Portugal)
|
| 2008/12/03 | Effect of adenosine A2A and ATP P2Y1 receptors blockade on pro-inflammatory mediated neurotoxicity in neurons | XXXIX Annual Meeting of the Portuguese Society of Pharmacology
Portuguese Society of Pharmacology (Lisboa, Portugal)
|
| 2006/12/05 | Methamphetamine alters NMDA and AMPA receptor subunit densities in the rat brain. | XXXVlI Annual Meeting of the Portuguese Society of Pharmacology
Portuguese Society of Pharmacology (Porto, Portugal)
|
| 2005/12/05 | Effect of subchronic and acute methamphetamine administration on the expression of ionotropic glutamate receptors in the rat hippocampus. | XXXVl Annual Meeting of the Portuguese Society of Pharmacology
Portuguese Society of Pharmacology (Lisboa, Portugal)
|
Supervision
| Thesis Title Role |
Degree Subject (Type) Institution / Organization |
|
|---|---|---|
| 2021/09/01 - 2022/07/31 | Impact of chronic stress on A2A receptors control of amygdala function
Supervisor of Ingride Luzio Gaspar
|
Master in Cellular and Molecular Biology
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
|
| 2018/09 - 2019/07/24 | Adenosinergic control of fear extinction: the role of adenosine A2A receptors in the basolateral amygdala
Supervisor of Vanessa Simões Lourenço
|
Master in Molecular and Cellular Biology (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
|
| 2016/09 - 2017/07/19 | Control of fear memory by adenosine receptors: role in the physiology of the related brain circuitry and implications for
fear extinction and post-traumatic stress disorder
Supervisor of Sara Cristina Lourenço dos Reis
|
Master in Cellular and Molecular Biology (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
|
Event participation
| Activity description Type of event |
Event name Institution / Organization |
|
|---|---|---|
| 2021/05/24 - 2021/05/24 | Oral presentation titled "A2A receptors in the amygdala are necessary and sufficient for the expression of mood dysfunction
upon chronic stress"
Seminar
|
3rd CIBB Neuroscience and Disease Retreat
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
|
| 2019/05/10 - 2019/05/10 | Oral presentation titled "Extinction of fear memories: a role for adenosine A2A receptors".
Seminar
|
Retreat of the area 'Neuroscience and Disease' of the Center for Innovation in Biomedicine and Biotechnology
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
|
| 2016/10/28 - 2016/10/28 | Oral presentation titled "Targeting adenosine A2A receptors in the amygdala: implications for fear memory and mood disorders".
Seminar
|
Seminar presented at the 'weekly seminars of the Center for Neuroscience and Cell Biology'
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
|
Jury of academic degree
| Topic Role |
Candidate name (Type of degree) Institution / Organization |
|
|---|---|---|
| 2021/12/10 | NT3/TrkC intracellular signaling in the processing of fear
(Thesis) Main arguer
|
Francisca Gonçalo da Silva (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
|
| 2017/07/10 | Role of epinephrine in fear memory
(Thesis) Arguer
|
Ester Sofia Pereira dos Santos Alves (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
|
| 2016/09/07 | Developing assays to assess structure and function of synapses in vitro
(Thesis) Main arguer
|
João Francisco Chibeles Rebelo Pestana Baptista (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
|
Course / Discipline taught
| Academic session | Degree Subject (Type) | Institution / Organization | |
|---|---|---|---|
| 2021/05/04 - Current | Ageing as a risk factor for brain diseases: senolytics. | Neuropharmacology (Mestrado integrado) | Universidade de Coimbra Faculdade de Medicina, Portugal |
| 2022/04/19 - 2022/04/19 | Fear, panic and PTSD: therapeutic perspectives. | Neuropharmacology (Mestrado integrado) | Universidade de Coimbra Faculdade de Medicina, Portugal |
| 2021/12/05 - 2021/12/05 | The amygdala: learning through emotions. | (Mestrado) | Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal |
| 2021/11/25 - 2021/11/25 | Stress from a synaptic perspective. | (Mestrado integrado) | Universidade de Coimbra Faculdade de Medicina, Portugal |
| 2021/11/24 - 2021/11/24 | Fear memory acquisition and extinction. | (Mestrado integrado) | Universidade de Coimbra Faculdade de Medicina, Portugal |
| 2021/11/17 - 2021/11/17 | Electrophysiology: extracellular and patch clamp recordings. | Tecnologias de Investigação em Neurobiologia (Mestrado integrado) | Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal |
| 2021/05/04 - 2021/05/04 | Medo, pânico e stress pós-traumático: perspectivas de intervenção terapêutica. | Neurofarmacologia (Mestrado) | Universidade de Coimbra Faculdade de Medicina, Portugal |
| 2021/01/13 - 2021/01/13 | Fear memory acquisition and extinction. | Neurofisiologia e cognição (Mestrado) | Universidade de Coimbra Faculdade de Medicina, Portugal |
| 2020/12/09 - 2020/12/09 | The amygdala: learning through emotions. | (Mestrado) | Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal |
| 2019/12/05 - 2019/12/05 | Neuronal Circuits and Behaviour: The amygdala: learning through emotions. | Circuitos Neuronais e Comportamento (Mestrado) | Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal |
| 2019/11/29 - 2019/11/29 | Biology and Physiology of Ageing: Perspectives on the control of senescence with ageing- senolytics. | Biologia e Fisiologia do Envelhecimento (Mestrado integrado) | Universidade de Coimbra Faculdade de Medicina, Portugal |
| 2019/11/14 - 2019/11/14 | Biology and Physiology of Ageing: Diet and ageing. | Biologia e Fisiologia do Envelhecimento (Mestrado integrado) | Universidade de Coimbra Faculdade de Medicina, Portugal |
| 2019/10/31 - 2019/10/31 | Technologies for Research in Neurobiology: Introduction to elecrophysiology. | Tecnologias de Investigação em Neurobiologia (Mestrado integrado) | Universidade de Coimbra Faculdade de Medicina, Portugal |
| 2019/04/04 - 2019/04/04 | Cellular and Molecular fundaments of Ageing: Inflammation and ageing. | Fundamentos Moleculares and Celulares do Envelhecimento | Universidade de Coimbra Faculdade de Medicina, Portugal |
| 2019/03/27 - 2019/03/27 | Neuropharmacology: fear, panic and post-traumatic stress- perspectives on therapeutic interventions | Neurofarmacologia (Mestrado) | Universidade de Coimbra Faculdade de Medicina, Portugal |
| 2018/12/10 - 2018/12/10 | Neuronal Circuits and Behaviour: The amygdala- learning through emotions. | Circuitos Neuronais e Comportamento (Mestrado) | Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal |
| 2018/11/30 - 2018/11/30 | Biology and Physiology of Ageing: Theories of systems controlling ageing; neuro-endocrine modifications; loss of mechanisms of homeostatic control. | Biologia e Fisiologia do Envelhecimento (Mestrado integrado) | Universidade de Coimbra Faculdade de Medicina, Portugal |
| 2018/11/22 - 2018/11/22 | Biology and Physiology of Ageing: Diet and ageing; prevention of cognitive and emotional decline with moderate caffeine consumption. | Biologia e Fisiologia do Envelhecimento (Mestrado integrado) | Universidade de Coimbra Faculdade de Medicina, Portugal |
| 2018/11/15 - 2018/11/15 | Biology and Physiology of Ageing: Mitochondrial theories of ageing; ageing and bioenergetics. | Biologia e Fisiologia do Envelhecimento (Mestrado integrado) | Universidade de Coimbra Faculdade de Medicina, Portugal |
| 2017/11/30 - 2017/11/30 | Biology of Drug Abuse: Behavioural evaluation in Neuroscience using rodent models | Biologia do Abuso de Drogas (Mestrado) | Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal |
Journal scientific committee
| Journal title (ISSN) | Publisher | |
|---|---|---|
| 2021/08/04 - 2022/08/31 | JoVE (1940-087X) | |
| 2021/04/04 - 2022/03/15 | Frontiers in Neuronal Circuits (16625110) |
Mentoring / Tutoring
| Topic | Student name | |
|---|---|---|
| 2022/03/02 - 2022/04/11 | Dissecting the role of caffeine and adenosine A2A receptors in the control of mood dysfunction | Maria Inês Esteves |
| 2022/02/07 - 2022/02/28 | Impact of chronic stress on A2A receptors control of amygdala function | Madalena Piteira |
| 2018/05/14 - 2018/06/08 | Adenosinergic modulation of fear extinction: focus on the role of A1 and A2A receptors in the amygdala | Ana Moreira de Sá |
| 2017/05/01 - 2017/06/30 | Evaluation of the adenosinergic system in a model of intrauterine ischaemia | Jorge Miguel Santos Castanheira |
| 2016/02/08 - 2016/07/29 | Impact of A2A Receptors in the sensory thalamus-amygdala pathway: relevance for fear acquisition and extinction | Juliana Silva |
| 2014/06/16 - 2014/07/04 | Downregulation of adenosine A2A receptors from the basolateral amygdala: impact on chronic stress | Tiago Campelo |
| 2009/03/01 - 2009/04/01 | Effect of pro-inflamatory cytokine IL-1ß on glutamate-induced excitotoxicity on hippocampal neurons | Marta Santos Esteves da Silva |
Distinctions
Award
| 2015 | Best Poster
Sociedade Portuguesa de Neurociências, Portugal
|
| 2014 | Best Poster
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
|
Other distinction
| 2021 | Scholarship
Sociedade Portuguesa de Neurociências, Portugal
|
| 2017 | Scholarship
Sociedade Portuguesa de Neurociências, Portugal
|
| 2012 | Post Doc grant (SFRH/BPD/91683/2012)
Fundação para a Ciência e a Tecnologia, Portugal
|
| 2006 | PhD grant (SFRH/BD/32145/2006)
Fundação para a Ciência e a Tecnologia, Portugal
|