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Vera Marisa Costa (VMC) has completed her PhD in Toxicology in 2009/06/23 in the University of Porto (Faculty of Pharmacy (FFUP).) She has been a Researcher in FFUP-ICETA under Norma Transitória. Currently, she holds the position of a scientific collaborator at UCIBIO/FFUP, waiting the signing of a new contract following her success in a recent application. VMC has published +100 articles in International Journals with Peer Review, mostly in Journals of Q1 on their fields. VMC is Associate Editor on four Journals: Brazilian Journal of Pharmaceutical Sciences, since 2019, Cardiovascular Toxicology (Springer-Nature Publishing) since 2020, Frontiers in Toxicology - Clinical Toxicology since 2022, and Helyion (Elsevier) since 2023. VMC has participated in the organization of 4 scientific events, being two international. She has extensive pegagogic experience in Pharmacology and Toxicology, being Invited Assistant Professor in CESPU and and colaborating in the Graduate Program of Bioexperimentação, Universidade of Passo Fundo, Brazil and FFUP. Her works focus on Medical and Health Sciences with emphasis on Pharmacology and Toxicology, maily focusing on Onco-Cardiology, Chemobrain and Toxin Toxicity. She was the principal investigator (PI) of two FCT funded projects on cardioncology: Why is mitoxantrone a poison to the heart? Focus on mitochondria, cytoskeleton, and metabolic bioactivation mechanisms (EXPL/DTP-FTO/0290/2012) and Poisoning the heart with anticancer drugs: is metabolic bioactivation or aging promotion the link to the cardiotoxicity of anticancer drugs? (PTDC/DTPFTO/1489/2014), with participation on several others as researcher, one of them international and EU funded. She also participitated/participates in 3 COST actions, as member: CA16225 - Realising the therapeutic potential of novel cardioprotective therapies; Bench to bedside transition for pharmacological regulation of NRF2 in noncommunicable diseases (BenBedPhar) CA20121 and CA21152 Implementation of science theory-based framework and toolkit to support cancer survivorship care. VMC has been an Evaluator of Scientific Projects of the Italian Ministry for University Research (MUR) since 2020, of the Executive Agency for Higher Education, Research, Development and Innovation Funding (UEFISCDI) of Romania and of the Science Fund of the Republic of Serbia since 2021, being that in the latter she was also Lead Reviewer. She presently is working for the Austrian Science Fund (FWF) and has been selected as expert for the DIANA programme. She is presently the (co)supervisor of 4 PhD students. VMC has (co)supervised four PhD students (one as principal) that have successfully accomplished their works and she has (co)supervised 17 MSc dissertation(s) (plus 3 are ongoing). Regarding her research activities, she is nvolved with several fields of research with high social /social impact: i) unraveling the anticancer drugs-elicited mechanisms underlying the onset of cardiotoxicity; ii) developing improved in vitro and in vivo models to predict the early cardiotoxic events in the field of cardio-oncology; iii) disclosing the adverse outcome pathways regarding the neurotoxicity of anticancer therapies; iv) optimization of tools to identify cancer patients poor quality of life; v) development of antidotes against mushroom toxicity; vii) the pharmacological and toxicological evaluation of compounds to be used against Alzheimer and Parkinsons diseases; viii) evaluation of toxicity of drugs of abuse. VMC is also involved with extension programs, that providing evidence-based recommendations to identify and manage cancer survivors poor quality of life. In her curriculum Ciência Vitae the most frequent terms in the context of scientific outputs are: chemotherapy, cardio-oncology, toxicology; catecolamines; doxorubicin; cardiac cells; in vivo; oxidative stress; amanitin; RNA polymerase II; oncology; antidotes; hepatotoxicity; MDMA; amphetamines; cathinones; chemobrain.
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Identificação

Identificação pessoal

Nome completo
Vera Marisa Freitas Costa

Nomes de citação

  • Costa, Vera
  • Costa, Vera Marisa
  • Costa, Vera M

Identificadores de autor

Ciência ID
601E-EFCD-E4D8
ORCID iD
0000-0002-0471-2756
Researcher Id
D-6284-2013
Scopus Author Id
17134373000

Endereços de correio eletrónico

  • veramcosta@ff.up.pt (Profissional)

Telefones

Telefone
  • 225026661 (Profissional)

Moradas

  • R. Jorge de Viterbo Ferreira 228, 4050-313, Porto, Porto, Portugal (Profissional)

Domínios de atuação

  • Ciências Médicas e da Saúde - Medicina Básica - Farmacologia e Farmácia
  • Ciências Médicas e da Saúde - Medicina Básica - Toxicologia
  • Ciências Médicas e da Saúde - Ciências da Saúde - Toxicodependência Alcoólica e de Outras Substâncias
  • Ciências Médicas e da Saúde - Medicina Básica - Neurociências
  • Ciências Médicas e da Saúde - Outras Ciências Médicas

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português (Idioma materno)
Inglês Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C1) Utilizador proficiente (C2) Utilizador proficiente (C1)
Francês Utilizador independente (B1) Utilizador independente (B1) Utilizador elementar (A2) Utilizador independente (B1) Utilizador elementar (A2)
Espanhol; Castelhano Utilizador independente (B1) Utilizador elementar (A2) Utilizador elementar (A2) Utilizador independente (B1) Utilizador elementar (A2)
Formação
Grau Classificação
2011/05/07 - 2011/05/12
Concluído
 Creating resources and activities in Moodle (Especialização pós-licenciatura)
Instituto Universitário de Ciências da Saúde, Portugal
 Approved
2005/02/01 - 2009/06/23
Concluído
 Toxicology (Doutoramento)
Especialização em Role of catecholamines and reactive oxygen species in the mechanism of oxidative stress-induced heart disease: in vitro studies using freshly isolated rat cardiomyocytes
Universidade do Porto Faculdade de Farmácia, Portugal
"Oxidative Stress in Heart Disease: Role of Catecholamines and Metals. in Vitro and Clinical Studies" (TESE/DISSERTAÇÃO)
 Unanimity
2009/05/15 - 2009/05/31
Concluído
 Laboratory Animal Sciences (Categoria C FELASA) (Pós-Graduação)
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
 Approved
2007/05/16 - 2007/05/18
Concluído
 Course on Animal Cell Culture (Especialização pós-licenciatura)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
 Approved
2006/12/01 - 2007/01/31
Concluído
 Statistical analysis of data with SPSS (Curso de Especialização Tecnológica)
ANJE Associação Nacional de Jovens Empresários, Portugal
 Approved
1998/10/01 - 2004/05/31
Concluído
 Pharmaceutical Sciences (Licenciatura)
Faculty of Pharmacy University of Porto, Portugal
 16
2003/10/06 - 2003/10/11
Concluído
 Internship at the Pharmacovigilance Unit (Especialização pós-licenciatura)
Universidade do Porto Faculdade de Medicina, Portugal
 Approved
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2018/02/09 - 2024/02/02 Investigador Contratado (Investigação) Universidade do Porto Instituto de Ciências e Tecnologias Agrárias e Agro-Alimentares, Portugal
Universidade do Porto Faculdade de Farmácia, Portugal
2016/09/01 - 2017/01/01 Pós-doutorado (Investigação) Fundação da Ciência e Tecnologia, Portugal
Universidade do Porto Instituto de Ciências e Tecnologias Agrárias e Agro-Alimentares, Portugal
2010/07/01 - 2016/12/31 Pós-doutorado (Investigação) Fundação da Ciência e Tecnologia, Portugal
Universidade do Porto Faculdade de Farmácia, Portugal

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2023/02/28 - 2023/07/31 Professor Auxiliar Convidado (Docente Universitário) Instituto das Ciências da Saúde do Norte, Portugal
Instituto das Ciências da Saúde do Norte, Portugal
2020/12/01 - 2022/07/31 Leitor (Docente Universitário) Faculty of Pharmacy University of Porto, Portugal
Universidade do Porto, Portugal
2020/12/01 - 2021/07/31 Assistente Convidado (Docente Universitário) Faculty of Medicine of University of Porto, Portugal
Departamento Ciências da Saúde Pública e Forenses, e Educação Médica, Portugal
2014/09/01 - 2018/09/01 Leitor (Docente Universitário) Faculty of Pharmacy of University of Porto, Portugal
Faculty of Pharmacy of University of Porto, Portugal
2009/03/01 - 2014/07/31 Professor Auxiliar Convidado (Docente Universitário) Universidade do Porto Faculdade de Medicina, Portugal
Universidade do Porto Faculdade de Medicina, Portugal
2007/09/01 - 2014/07/31 Professor Auxiliar Convidado (Docente Universitário) Instituto Universitário de Ciências da Saúde, Portugal
Instituto Universitário de Ciências da Saúde, Portugal
2007/01/01 - 2010/06/30 Leitor (Docente Universitário) Universidade de Trás-os-Montes e Alto Douro Escola Superior de Enfermagem de Vila Real, Portugal
Universidade de Trás-os-Montes e Alto Douro Escola Superior de Enfermagem de Vila Real, Portugal

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2024/02/09 - Atual Scientific Collaborator Faculty of Pharmacy University of Porto, Portugal
Unidade de Ciências Biomoleculares Aplicadas, Portugal
2017/01/01 - 2018/02/07 Invited Scientist Grant Universidade do Porto Instituto de Ciências e Tecnologias Agrárias e Agro-Alimentares, Portugal
Universidade do Porto Instituto de Ciências e Tecnologias Agrárias e Agro-Alimentares, Portugal
2005/02/01 - 2009/06/23 PhD Student Fundação da Ciência e Tecnologia, Portugal
Faculty of Pharmacy University of Porto, Portugal
2004/06/01 - 2005/01/31 Pharmacist Sto. António Pharmacy, Portugal
Sto. António Pharmacy, Portugal
Projetos

Projeto

Designação Financiadores
2023/02/24 - Atual COST CA21152- Implementation Network Europe for Cancer Survivorship Care (INE-CSC)
CA21152
Investigador
European Cooperation in Science and Technology, Bélgica
2023/01/01 - Atual DynaPro: Probing Dynamic Chirality to the Rescue of Melanostatin in Parkinson's Therapy
2022.01175.PTDC
Investigador
REQUIMTE LAQV Porto, Portugal
 Fundação da Ciência e Tecnologia
Em curso
2021/11/15 - Atual COST CA20121 - Bench to bedside transition for pharmacological regulation of NRF2 in noncommunicable diseases
COST CA20121
Investigador
European Cooperation in Science and Technology, Bélgica
Em curso
2021/01/01 - 2025/12/31 Institute for Health and Bioeconomy
LA/P/0140/2020
10.54499/LA/P/0140/2020
Investigador
Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal

Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal

Universidade NOVA de Lisboa, Portugal

INESC Microsistemas e Nanotecnologias, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Associação para a Inovação e Desenvolvimento da FCT, Portugal

Unidade de Ciências Biomoleculares Aplicadas, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2020/01/01 - 2023/12/31 Applied Molecular Biosciences Unit
UIDP/04378/2020
10.54499/UIDP/04378/2020
Investigador
Universidade NOVA de Lisboa, Portugal

Unidade de Ciências Biomoleculares Aplicadas, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Associação para a Inovação e Desenvolvimento da FCT, Portugal

Universidade do Porto Instituto de Ciências Tecnologias e Agroambiente, Portugal

Universidade do Porto, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2020/09/01 - 2023/08/31 Open access Educational Materials On Naturally Occurring Molecules - sources, biological activity and use - ERASMUS+
2020-1-CZ01-KA203-078218
Investigador
Univerzita Karlova Farmaceutická Fakulta v Hradci Králové, República Checa
 European Comission Erasmus +
Em curso
2022/01/01 - 2023/06/30 Methylphenidate and amphetamine-induced synaptogenesis and neurite outgrowth in attention deficit hyperactivity disorder (ADHD)
EXPL/MED-FAR/0203/2021
Investigador
Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2021/08/02 - 2022/04/18 COST CA16225 - COST Action Realising the therapeutic potential of novel cardioprotective therapies
COST CA16225
Investigador
European Cooperation in Science and Technology, Bélgica
 European Cooperation in Science and Technology Action Disaster Bioethics
Concluído
2021/09/21 - 2022/02/28 SCRAtis - 2-Estirilcromonas no tratamento da artrite reumatoide: possível alternativa terapêutica?
PTDC/MED-QUI/29253/2017
Investigador
REQUIMTE LAQV Porto, Portugal
 Fundação para a Ciência e a Tecnologia
2019/01/01 - 2019/12/31 Unidade de Ciências Biomoleculares Aplicadas
UID/Multi/04378/2019
Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2016/07/11 - 2019/12/31 Poisoning the heart with anticancer drugs: is metabolic bioactivation or aging promotion the link to the cardiotoxicity of anticancer drugs?
PTDC/DTP-FTO/1489/2014
PTDC/DTPFTO/ 1489/2014
Investigador responsável
Universidade de Aveiro, Portugal

Universidade do Porto Faculdade de Desporto, Portugal
Fundação para a Ciência e a Tecnologia

Fundação da Ciência e Tecnologia
Concluído
2016/06/01 - 2019/07/31 DESignBIOtecHealth - New Technologies for three Health Challenges of Modern Societies: Diabetes, Drug Abuse and Kidney Diseases
NORTE-01-0145-FEDER-000024
Investigador
European Regional Development Fund
Concluído
2016/05/01 - 2016/11/30 Development of antidotes for Amanita phalloides intoxications, from in silico to the intoxicated patient
PTDC-DTP-FTO-4973-2014 – POCI-01-0145-FEDER 016545
Investigador
Fundação da Ciência e Tecnologia
Concluído
2013/05/02 - 2014/10/31 WHY IS MITOXANTRONE A POISON TO THE HEART? FOCUSSING ON THE MITOCHONDRIA, CYTOSKELETON, AND METABOLIC BIOACTIVATION MECHANISMS
EXPL/DTP-FTO/0290/2012
REQUIMTE LAQV Porto, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2013/05/01 - 2014/10/31 Why is mitoxantrone a poison to the heart? Focus on mitochondria, cytoskeleton, and metabolic bioactivation mechanisms.
EXPL/DTP-FTO/0290/2012
Investigador responsável
Universidade do Porto Instituto de Ciências e Tecnologias Agrárias e Agro-Alimentares, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Universidade do Porto Faculdade de Desporto, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Associação para a Inovação e Desenvolvimento da FCT, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2010/03/01 - 2013/11/30 IMPLICATIONS OF AMPHETAMINE PSYCHOSTIMULANTS ABUSE IN BRAIN AGING
PTDC/SAU-FCF/102958/2008
Universidade do Porto Instituto de Ciências e Tecnologias Agrárias e Agro-Alimentares, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Universidade de Coimbra, Portugal

Associação para a Inovação e Desenvolvimento da FCT, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2010/06/01 - 2013/06/30 A role for Nrf2/ARE cytoprotective signalling in iron overload. Adaptive response to oxidative stress as a disease modifier in HFE-associated hereditary hemochromatosis.
PTDC/SAU-FCF/101177/2008
Investigador
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Universidade do Porto Instituto de Ciências e Tecnologias Agrárias e Agro-Alimentares, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2011/01/01 - 2012/12/31 Strategic Project - LA 6 - 2011-2012
PEst-C/EQB/LA0006/2011
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Universidade do Porto Instituto de Ciências Tecnologias e Agroambiente, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2007/01 - 2009/09 OXIDATIVE STRESS IN HEART DISEASE: ROLE OF CATECHOLAMINES
Provided by PTCRIS: 82340
82340
Bolseiro de Doutoramento
Faculty of Pharmacy of University of Porto, Portugal
 Fundação para a Ciência e a Tecnologia, I.P.
Concluído
2005/10/01 - 2007/12/31 Stress oxidativo na Doença Cardíaca: acção das catecolaminas
POCI/SAU-OBS/55849/2004
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Aveiro, Portugal

Universidade do Porto Instituto de Ciências Tecnologias e Agroambiente, Portugal

REQUIMTE LAQV Porto, Portugal
Fundação para a Ciência e a Tecnologia
Concluído

Outro

Designação Financiadores
2020/01/01 - 2023/12/31 Applied Molecular Biosciences Unit
UIDB/04378/2020
10.54499/UIDB/04378/2020
Universidade do Porto, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Universidade do Porto Instituto de Ciências Tecnologias e Agroambiente, Portugal

Unidade de Ciências Biomoleculares Aplicadas, Portugal

Associação para a Inovação e Desenvolvimento da FCT, Portugal

Universidade NOVA de Lisboa, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2015 - 2021 UnIdade Ciências Biomoleculares Aplicadas
4378
Investigador
Fundação da Ciência e Tecnologia
Produções

Publicações

Artigo em conferência
  1. Vitorino-Oliveira, Cláudia; Kahremany, Shirin; Nissim, Laura; Duarte-Araújo, Margarida; Carvalho, Félix; Gruzman, Arie; Costa, Vera Marisa. "The cytotoxicity of doxorubicin, sunitinib and bortezomib in AC16 cardiac cells and possible therapeutic options involving redox pathways". Trabalho apresentado em SPF 2021 - 54th Meeting of Portuguese Society of Pharmacology, 42nd Meeting of the Clinical Pharmacology and 23rd Meeting of the Toxixology, Lisboa, 2024.
  2. Vitorino-Oliveira, Cláudia; Duarte-Araújo, Margarida; Carvalho, Félix; Costa, Vera Marisa. Autor correspondente: Costa, Vera Marisa. "The effect of the glutathione pathway on the cytotoxicity of sunitinib, doxorubicin and bortezomib in AC16 cells". Trabalho apresentado em XVII Meeting of Young Researchers of University of Porto, Porto, 2023.
    Publicado
  3. Brandão, Sofia; Filipa Reis-Mendes, Ana; Neuparth, Maria João; Carvalho, Félix; Ferreira, Rita; Costa, Vera M. "Cardiac mitochondrial dynamics, autophagy and regeneration are stirred by doxorubicin in old CD-1 mice". Trabalho apresentado em II TOX-RUN 2023, Porto, 2023.
    Publicado
  4. Vitorino-Oliveira, Claúdia; Kahremany, S; Nisim, L; Duarte-Araújo, M.; Carvalho, Félix; Gruzman, Arie; Costa, Vera M. "The influence of glutathione pathway modulators on the cytotoxicity of sunitinib, doxorubicin and bortezomib in AC16 cardiac cells". Trabalho apresentado em II TOX-RUN 2023, Porto, 2023.
    Publicado
  5. Carvalho, Ana; Ferreira, Mariana; Filipa Reis-Mendes, Ana; Ferreira, Rita; Bastos, Maria De Lourdes; Fernandes, Eduarda; Sá, Susana I; Sá SI; et al. "Unveiling the neurotoxicity of mitoxantrone: oxidative stress, apoptosis, and autophagy in the brain of adult CD-1 mice". Trabalho apresentado em 8th International Electronic Conference on Medicinal Chemistry, 2022.
    Publicado
  6. Costa, Vera M. "In the Heart of Cardio-Oncology: The Targets and Biomarkers of Cardiotoxicity in Anticancer Drugs". Trabalho apresentado em 8th International Electronic Conference on Medicinal Chemistry, 2022.
    Publicado • 10.3390/ecmc2022-13157
  7. Costa-Almeida, Hugo F.; Sampaio-Dias, Ivo E.; Sara C. Silva-Reis; Correia, XC; Costa, Vera M; Carvalho, Felix; Garía-Mera, X; Rodríguez-Borges, JE. "Synthesis, Pharmacological, and Toxicological Evaluation of Potent Melanostatin Peptidomimetics Incorporating Chiral ß-Amino Acids as Proline Surrogates". Trabalho apresentado em 8th International Electronic Conference on Medicinal Chemistry, Online, 2022.
    Publicado
  8. Ferreira, Mariana; Carvalho, Félix; Costa, Vera M; Capela, João Paulo. "Evaluating the potential of methylphenidate and amphetamine acute exposure to promote neurite outgrowth and synaptogenesis in differentiated SH-SY5Y neuronal cells". Trabalho apresentado em 8th International Electronic Conference on Medicinal Chemistry, Online, 2022.
    Publicado
  9. Brandão, Sofia; Reis-Mendes, A.; Duarte-Araujo, M.; Neuparth, Maria João; Carvalho, Félix; Ferreira, Rita; Costa, Vera M. "Mitoxantrone disrupts cardiac metabolism along with proteolysis and regeneration in aged mice". Trabalho apresentado em 8th International Electronic Conference on Medicinal Chemistry, Online, 2022.
    Publicado
  10. Sara C. Silva-Reis; Ivo E. Sampaio-Dias; Almeida, Hugo; Costa, Vera M; García-Mera, Xerardo; Rodríguez-Borges, JA. "Chemical Strategy to Improve Bioavailability of Glypromate Peptide-Conjugates". Trabalho apresentado em 8th International Electronic Conference on Medicinal Chemistry, Online, 2022.
    Publicado
  11. Carvalho, Ana; Ferreira, Mariana; Reis-Mendes, Ana; Ferreira, Rita; Fernandes, Eduarda; Sá, Susana I; Capela, João Paulo; Carvalho, Félix; Costa, Vera M. "Mitoxantrone-induced neurotoxicity in CD-1 mice.". Trabalho apresentado em I TOXRUN, Porto, 2022.
    Publicado
  12. Brandão, Sofia Reis; Filipa Reis-Mendes, Ana; Duarte-Araujo, M.; Neuparth, Maria João; Carvalho, Félix; Ferreira, Rita; Costa, Vera M. "Molecular alterations underlying Doxorubicin’s Chronic Cardiotoxicity in a mouse model". Trabalho apresentado em I TOXRUN, Porto, 2022.
    Publicado
  13. Araújo, Ana Margarida; Carvalho, Márcia; Costa, Vera; Duarte, José Alberto; Dinis-Oliveira, Ricardo; Bastos, Maria de Lourdes; Guedes de Pinho, Paula; Carvalho, Félix. "A translational in vitro and in vivo metabolomics study reveals altered hepatic metabolic pathways after acute exposure to 3,4-methylenedioxypyrovalerone". 2021.
  14. Araújo, Ana Margarida; Carvalho, Márcia; Costa, Vera Marisa; Duarte, José Alberto; Dinis-Oliveira, Ricardo; Bastos, Maria de Lourdes; Guedes de Pinho, Paula; et al. "Early pathways of toxicity triggered by 3,4-methylenedioxypyrovalerone unveiled by in vivo toxicometabolomics". Trabalho apresentado em EUROTOX, 2021.
    10.1016/S0378-4274(21)00553-1
  15. Carvalho, Ana Rita; Reis-Mendes, A.; Duarte-Araujo, Margarida; Carvalho, Félix; Bastos, Maria de Lourdes; Sá, Susana I; Capela, João Paulo; Costa, Vera M. "Mitoxantrone impairs Bax and phosphorylated Tau expression on the brain of adult mice: an in vivo ‘chemobrain’ study on clinically relevant doses.". Trabalho apresentado em 15th YES Meeting Porto 2020, Porto, 2020.
    Publicado • 10.1097/j.pbj.0000000000000100
  16. Reis-Mendes, Ana; Duarte-Araújo, Margarida; Duarte, José Alberto; Gonçalves-Monteiro, Salomé; Remião, Fernando; Carvalho, Félix; Sousa, Emília; Bastos, Maria Lourdes; Costa, Vera Marisa. "Anticancer drugs-induced toxicity in different age male CD-1 mice". Trabalho apresentado em 5th International Electronic Conference on Medicinal Chemistry, 2019.
    10.3390/ecmc2019-06365
  17. Dias-Carvalho, Ana; Reis-Mendes, Ana; Duarte-Araújo, Margarida; Carvalho, Félix; Bastos, Maria Lourdes; Sá, Susana I.; Capela, João Paulo; Costa, Vera Marisa. "Effects of Doxorubicin and Mitoxantrone in the brain of differently aged mice: in vivo chemobrain study". Trabalho apresentado em 5th International Electronic Conference on Medicinal Chemistry, 2019.
    10.3390/ecmc2019-06364
  18. Brandão, Sofia; Reis-Mendes, Ana; Carvalho, Félix; Bastos, Maria; Ferreira, Rita; Costa, Vera. "Disclosing the effect of doxorubicin and mitoxantrone on cardiac mitochondrial proteome: an in vivo approach using a murine model". Trabalho apresentado em 5th International Electronic Conference on Medicinal Chemistry, 2019.
    10.3390/ecmc2019-06350
  19. Malheiro, Rui Filipe; Costa, Vera Marisa; Bastos, Maria de Lourdes; Carvalho, Félix. "In vitro toxicity of alpha-amanitin in human kidney cells and evaluation of protective effect of polymyxin B". Trabalho apresentado em 5th International Electronic Conference on Medicinal Chemistry, 2019.
    10.3390/ecmc2019-06360
  20. Dionísio, Flávio; Araújo, Ana Margarida; Araújo, Margarida Duarte; de Pinho, Paula Guedes; Bastos, Maria de Lourdes; Carvalho, Félix; Costa, Vera Marisa. "The main products of cyclophosphamide bioactivation exert a cardiotoxic effect at clinical important concentrations in AC16 cardiac cells". Trabalho apresentado em 5th International Electronic Conference on Medicinal Chemistry, 2019.
    10.3390/ecmc2019-06366
  21. Carvalho, Ana Rita; Reis-Mendes, A.; Duarte-Araújo, M.; Guedes, Rita; Monteiro, Salomé; Carvalho, Félix; Bastos, Maria de Lourdes; Capela, João Paulo; Costa, Vera M. "In vivo chemobrain study: the effects of doxorubicin and mitoxantrone in the brain of differently aged mice.". Trabalho apresentado em 14th YES Meeting, Porto, 2019.
    Publicado
  22. Soares, Jorge; Costa, Vera M; Bronze, Silvia; Gaspar, Helena; Santos, Susana; Bastos, Maria De Lourdes; Carvalho, Felix; Capela, João Paulo. "Mitochondrial impairment and oxidative stress play an important role in the toxicity of synthetic cathinones to dopaminergic SH-SY5Y cells". Trabalho apresentado em 55th Annual Meeting of the Society of the European Toxicology Society - EUROTOX 2019, Helsinki, 2019.
  23. Rodrigues, Daniela; Costa, Vera M; Bastos, Maria Lourdes; Carvalho, Félix. "Effects of alpha-amanitin in HepG2 cells are not prevented by drugs used in Amanita phalloides intoxications". Trabalho apresentado em 55th Annual Meeting of the Society of the European Toxicology Society - EUROTOX 2019, 2019.
    10.1016/j.toxlet.2019.09.002
  24. Dionísio, Flávio; Duarte-Araújo, Margarida; Bastos, Maria de Lourdes; Carvalho, Félix; Costa, Vera M. "Cyclophosphamide metabolites 4-hydroxycyclophosphamide and acrolein exert strenuous cardiotoxicity in AC16 human cardiomyocytes, at clinical relevant concentrations". Trabalho apresentado em EUROTOX 2019 - 55th Annual Meeting of the Society of the European Toxicology Society, 2019.
    Publicado
  25. Brandão, Sofia; Ana Reis-Mendes; Bastos, Maria Bastos; Carvalho, Félix Dias; Ferreira, Rita; Costa, Vera M; Brandão, Sofia; et al. "Exploring the effect of anticancer drugs doxorubicin and mitoxantrone on cardiac mitochondrial plasticity using a proteomic approach". Trabalho apresentado em 55th Annual Meeting of the Society of the European Toxicology Society - EUROTOX 2019, Helsinki, 2019.
  26. Dias-Carvalho, Ana; Filipa Reis-Mendes, Ana; Duarte-Araújo, Margarida; Guedes, Rita; Gonçalves-Monteiro, Salomé; Carvalho, Félix Dias; Bastos, Maria de Lourdes; Capela, João Paulo; Costa, Vera M. "Doxorubicin and mitoxantrone effects on the brain of differently aged mice: an in vivo chemobrain study". Trabalho apresentado em 55th Congress of European Societies of Toxicology, (Eurotox 2019) Helsinki, Finland, Helsinki, 2019.
    Publicado
  27. Reis-Mendes, Ana; Duarte-Araujo, Margarida; Duarte, Jose Alberto; Goncalves-Monteiro, Salome; Carvalho, Felix; Bastos, Maria Lourdes; Sousa, Emilia; Costa, Vera Marisa. "Evaluation of the toxicity induced by doxorubicin in different age male CD-1 mice". Trabalho apresentado em 53rd Annual Scientific Meeting of the European Society for Clinical Investigation "The Clocks of Metabolism and Disease", Coimbra, Portugal, Coimbra, 2019.
  28. Reis-Mendes, Ana; Duarte-Araujo, Margarida; Duarte, Jose Alberto; Goncalves-Monteiro, Salome; Carvalho, Felix; Bastos, Maria Lourdes; Sousa, Emilia; Costa, Vera Marisa. "Mitoxantrone-induced toxicity in different age male CD-1 mice". Trabalho apresentado em 53rd Annual Scientific Meeting of the European Society for Clinical Investigation "The Clocks of Metabolism and Disease", Coimbra, Portugal, Coimbra, 2019.
  29. Dionísio, Flávio; Duarte-Araujo, Margarida; Bastos, Maria de Lourdes; REQUIMTE - Laboratório de Toxologia, Departamento de Ciências Biológicas, Faculdade de Farmáci; Carvalho, Félix Dias; Costa, Vera M. "The main metabolites of cyclophosphamide, 4-hydroxycyclophosphamide and acrolein, are cardiotoxic at relevant clinical concentrations.". Trabalho apresentado em 14th YES Meeting Porto, Porto, 2019.
    Publicado • 10.1097/j.pbj.0000000000000054
  30. Remião, Fernando; Carmo, Helena; Gomes, AM; Silva, Renata; Costa, Vera M; Carvalho, Félix; Bastos, Maria De Lourdes. "Video lecture capture (VLC) - impacto na aprendizagem dos estudantes". Trabalho apresentado em Congr. Nac. Práticas Pedagógicas no Ensino Superior, 2019.
    Publicado
  31. Reis-Mendes, A.; Carvalho, F.; Sousa, E.; Remião, F.; Bastos, M.D.L.; Costa, V.M.. "Cardiotoxicity of FAC (5-Fluorouracil + Adriamycin + Cyclophosphamide) Metabolotes in H9c2 Cardiac Differentiated Cells". Trabalho apresentado em 54th Congress of European Societies of Toxicology, (Eurotox 2018) Brussels, Belgium, Brussels, 2018.
    10.1016/j.toxlet.2018.07.029
  32. Carvalho, Ana Rita; Ana Reis-Mendes; Duarte-Araujo, Margarida; Guedes, Rita; Gonçalves-Monteiro, Salomé; Carvalho, Félix; Bastos, Maria De Lourdes; Capela, João Paulo; Costa, Vera M. "Differential effects of doxorubicin and mitoxantrone in brain glutathione levels of different aged mice". Porto, 2018.
    Publicado
  33. Remião, Fernando; Rocha-pereira, Carolina; Costa, Vera M; Silva, Renata; Soares, Jorge; Casanova, Alfredo G; Carmo, Helena. "TOX-OER MOOC: uma ferramenta para o ensino e a aprendizagem". Trabalho apresentado em CNaPPES 2018 - Congr. Nac. Práticas Pedagógicas no Ensino Superior, 2018.
    Publicado
  34. Hrynchak, Ivanna; Sousa, Emília; de Lourdes Bastos, Maria; Pinto, Madalena; Costa, Vera Marisa. "Studies towards the synthesis of dicarboxylic acid metabolite of mitoxantrone". Trabalho apresentado em 12nd International YES Meeting, Porto, Portugal, Porto, 2017.
    10.1016/j.pbj.2017.07.107
  35. Araújo, Silvana da Costa; Costa, Vera M; Pereira, Frederico; Fernandes, Eduarda; Bastos, Maria De Lourdes; Carvalho, Félix; Capela, João Paulo. "‘Ecstasy’ and amphetamine neurotoxicity to cultured rat cortical neurons in a continuous exposure model". Trabalho apresentado em EUROTOX 2013 - 49th Congress of the European Societies of Toxicology, Interlaken, 2013.
    Publicado
  36. Costa, Vera M; Capela, João Paulo; Bastos, Maria De Lourdes; Duarte, Jose Alberto; Remião, Fernando; Carvalho, Félix. "Pharmacological concentrations of mitoxantrone are able to transiently activate caspases and dually modify glutathione pathways in HL-1 cells.". Trabalho apresentado em EUROTOX 2013 - 49th Congress of the European Societies of Toxicology, Interlaken, 2013.
    Publicado
  37. Araújo, Silvana da Costa; Costa, Vera M; Pereira, Frederico; Fernandes, Eduarda; Bastos, Maria De Lourdes; Carvalho, Félix; Capela, João Paulo. "‘Ecstasy’ and amphetamine neurotoxicity to cultured rat cortical neurons in a continuous exposure model". Trabalho apresentado em 6th European Congress on Pharmacology EPHAR 2012, Granada, 2012.
    Publicado
  38. Costa, Vera M; Capela, João Paulo; Bastos, Maria De Lourdes; Duarte, Jose Alberto; Remião, Fernando; Carvalho, Félix. "Pharmacological concentrations of mitoxantrone are able to activate caspases and dually modify glutathione pathways in HL-1 cardiomyocytes.". Trabalho apresentado em 6th European Congress on Pharmacology EPHAR 2012, Granada, 2012.
    Publicado
  39. Rossato, Luciana Grazziotin; Costa, Vera M; Dallegrave, Eliane; Bastos, Maria De Lourdes; Dinis-Oliveira, Ricardo Jorge; Duarte, José A.; Palmeira, Carlos; Remião, Fernando. "Mitoxantrone: A comparative study of early and late toxic effects in rats". Trabalho apresentado em 2012 EUROTOX 48th Congress of the European Societies of Toxicology, Stockholm, 2012.
    Publicado
  40. Araújo, Silvana da Costa; Costa, Vera M; Pereira, Frederico C; Fernandes, Eduarda; Bastos, Maria De Lourdes; Carvalho, Félix; Capela, João Paulo. "‘Ecstasy’ and amphetamine induce developmental neurotoxicity to immature cultured rat cortical neurons". Trabalho apresentado em EUROTOX 2011 - 47th Congress of the European Societies of Toxicology, Paris, 2011.
    Publicado
  41. Araújo, Silvana da Costa; Costa, Vera M; Ruscher, Karsten; Bastos, Maria De Lourdes; Dirnagl, Ulrich; Meisel, Andreas; Carvalho, Félix; Capela, João Paulo. "Hallucinogenic amphetamines neurotoxicity in cultured hippocampal neurons.". Trabalho apresentado em EUROTOX 2011 - 47th Congress of the European Societies of Toxicology, Paris, 2011.
    Publicado
  42. Costa, Vera M; Capela, João Paulo; Bastos, Maria De Lourdes; Remião, Fernando; Duarte, Jose Alberto; Carvalho, Félix. "N-acetyl-cysteine prevents the cytotoxicity of adrenaline oxidation in SH-SY5Y cells". Trabalho apresentado em EUROTOX 2011 - 47th Congress of the European Societies of Toxicology, Paris, 2011.
    Publicado
  43. Rossato, Luciana G.; Costa, Vera M; Firmo, Eduarda; Bastos, Maria Bastos; Palmeira, Carlos; Remião, Fernando. "Therapeutic concentrations of mitoxantrone elicit cytotoxic effects on H9c2 cells". Trabalho apresentado em EUROTOX 2011 - 47th Congress of the European Societies of Toxicology, Paris, 2011.
    Publicado
  44. Duarte, Tiago; Bento, A; Picarote, G; Costa, Vera M; Carvalho, Félix. "Understanding the role of NRF2/ARE signalling in the cellular defence against iron toxicity". Trabalho apresentado em International BioIron Society Biennial World Meeting (IBIS 2011 - Vancouver), Vancouver, 2011.
    Publicado
  45. Rossato, Luciana Grazziotin; Costa, Vera M; de Pinho, Paula Guedes; Carvalho, Félix; Carmo, Helena; Bastos, Maria De Lourdes; Remião, Fernando. "Role of organic cation mediated transport and oxidative stress in the synephrine induced-toxicity in freshly isolated cardiomyocytes. Toxicol Lett 196S: S142.". Trabalho apresentado em 2010 IUTOX International Congress of Toxicology, Barcelona, 2010.
    Publicado
  46. Rossato, Luciana Grazziotin; Costa, Vera M; de Pinho, Paula Guedes; Silva, Renata; Carvalho, Félix; Carmo, Helena; Bastos, Maria de Lourdes; Remião, Fernando. "Development of a GC/IT-MS method for simultaneous quantification of para and meta-synephrine in Caco-2 cells". Trabalho apresentado em 2010 IUTOX International Congress of Toxicology, Barcelona, 2010.
    Publicado
  47. Costa, Vera Marisa; Carvalho, Felix; de Lourdes Bastos, Maria; Carvalho, Rui; Carvalho, Márcia; Remião, Fernando. "Time dependent activation of transcription factors in freshly isolated cardiomyocytes: Adrenaline and reactive oxygen species incubation". Trabalho apresentado em Abstracts of the 44th Congress of the European Societies of Toxicology (EUROTOX 2007), 2009.
    10.1016/j.toxlet.2007.05.036
  48. Costa, Vera M; Silva, Renata; Tavares, Ludgero Canario; Vitorino, Rui; Amado, Francisco; Carvalho, Félix; Bastos, Maria De Lourdes; et al. "Adrenaline and reactive oxygen species, elicit proteome and energetic metabolism modifications in freshly isolated rat cardiomyocytes". Trabalho apresentado em EUROTOX 2009 - 46th Congress of the European Societies of Toxicology, Dresden, 2009.
    Publicado
  49. Rossato, Luciana Grazziotin; Carmo, Helena; Carvalho, Félix; de Lourdes Bastos, Maria; Costa, Vera Marisa; Remião, Fernando. "meta-Synephrine induces oxidative stress in freshly isolated cardiomyocytes". Trabalho apresentado em 46th Congress of the European Societies of Toxicology (EUROTOX 2009), Dresden, 2009.
    10.1016/j.toxlet.2009.06.428
  50. Oliveira, Susana; Almeida, SF ; Picarote, Gonçalo; Costa, Vera M; Carvalho, Félix; Azevedo, JE; Pinto, Jorge P; Sousa, Maria. "Activation of an unfolded protein response modulates the expression of iron-related genes". Trabalho apresentado em 2009 International BioIron Society Meeting, Porto, 2009.
    Publicado
  51. Costa, Vera M.; Ferreira, Luísa M.; Branco, Paula S.; Carvalho, Félix; Bastos, Maria L.; Carvalho, Rui A.; Carvalho, Márcia; Remião, Fernando. "Characterization of adrenaline and adrenaline-GSH adduct transport in freshly isolated rat cardiomyocytes". Trabalho apresentado em 45th Congress of European Societies of Toxicology, (Eurotox 2008), Rhodes, 2008.
    10.1016/j.toxlet.2008.06.405
  52. Costa, Vera; Silva, Renata; Ferreira, Luísa; Branco, Paula; Carvalho, Félix; Bastos, Maria Lourdes; Carvalho, Rui; Carvalho, Márcia; Remião, Fernando. "Oxidation process of adrenaline in freshly isolated rat cardiomyocytes: Formation of adrenochrome, quinoproteins and Gsh-adduct". Trabalho apresentado em 44th Congress of the European Societies of Toxicology (EUROTOX 2007), Amsterdam, 2007.
    10.1016/j.toxlet.2007.05.189
  53. Silva, Renata; Costa, Vera Marisa; Boldt, Silvia; Carmo, Helena; Carvalho, Félix; Bastos, Maria Lourdes. "Validation of a HPLC-ECD method for the detection of adrenaline-GSH adducts in biological samples". Trabalho apresentado em EUROTOX 2006/6 CTDC Congress, Cravtat, Croatia, Catvat, 2006.
    10.1016/J.TOXLET.2006.06.277
  54. Costa, Vera M; Carvalho, Márcia; Carvalho, Félix; Bastos, Maria De Lourdes; Carvalho, Rui; Remião, Fernando. "Effect of catecholamine and free radicals on calcium tolerant cardiomyocytes: adduct formation". Trabalho apresentado em 43rd Congress of the European Societies of Toxicology and the 6th Congress of Toxicology in Developing Countries, Cavtat, Croatia, Cavtat, 2006.
    Publicado
  55. Silva, Renata; Costa, V.; Boldt, Silvia; Carmo, H.; Carvalho, Félix; Carvalho, Márcia; Carvalho, Rui Albuquerque; Bastos, M. Lourdes; Remião, Fernando. "Detection of GSH adducts of catechoamines in biological samples". Trabalho apresentado em 42nd Congress of the European Societies of Toxicology (EUROTOX 2005), Cracow, 2005.
Artigo em revista
  1. Silva-Reis, Sara C.; Costa, Vera M; Correia da Silva, Daniela; Pereira, David M.; Correia, Xavier Cruz; Costa-Almeida, Hugo F.; García-Mera, Xerardo; Rodríguez-Borges, José E.; Sampaio-Dias, Ivo E.. "Exploring structural determinants of neuroprotection bias on novel glypromate conjugates with bioactive amines". European Journal of Medicinal Chemistry 267 (2024): 116174. http://dx.doi.org/10.1016/j.ejmech.2024.116174.
    Publicado • 10.1016/j.ejmech.2024.116174
  2. Reis-Mendes, Ana; Vitorino-Oliveira, Cláudia; Ferreira, Mariana; Carvalho, Félix; Remião, Fernando; Sousa, Emília; de Lourdes Bastos, Maria; Costa, Vera M. Autor correspondente: Costa, Vera M. "Comparative In Vitro Study of the Cytotoxic Effects of Doxorubicin’s Main Metabolites on Cardiac AC16 Cells Versus the Parent Drug". Cardiovascular Toxicology 24 3 (2024): 266-279. http://dx.doi.org/10.1007/s12012-024-09829-6.
    Publicado • 10.1007/s12012-024-09829-6
  3. Rocha, Sónia; Amaro, Andreia; Ferreira-Junior, Marcos D.; Proença, Carina; Silva, Artur M. S.; Costa, Vera M; Oliveira, Sara; et al. "Melanoxetin: A Hydroxylated Flavonoid Attenuates Oxidative Stress and Modulates Insulin Resistance and Glycation Pathways in an Animal Model of Type 2 Diabetes Mellitus". Pharmaceutics 16 2 (2024): 261. http://dx.doi.org/10.3390/pharmaceutics16020261.
    Publicado • 10.3390/pharmaceutics16020261
  4. Sara C. Silva-Reis; Costa, Vera Marisa; da Silva, Daniela Correia; Pereira, David; Correia, Xavier Cruz; Costa-Almeida, Hugo F.; García-Mera, Xerardo; J. E. Rodriguez-Borges; Ivo E. Sampaio-Dias. Autor correspondente: Ivo E. Sampaio-Dias. "Exploring Structural Determinants of Neuroprotection Bias on Novel Glypromate Conjugates with Bioactive Amines". European Journal of Medicinal Chemistry (2024):
    Aceite para publicação
  5. Dias-Carvalho, Ana; Sá, Susana Isabel; Carvalho, Félix; Fernandes, Eduarda; Costa, Vera M. Autor correspondente: Costa, Vera M. "Inflammation as common link to progressive neurological diseases". Archives of Toxicology 98 1 (2024): 95-119. http://dx.doi.org/10.1007/s00204-023-03628-8.
    Acesso aberto • 10.1007/s00204-023-03628-8
  6. Reis-Mendes, A.; Vitorino-Oliveira, Claúdia; Remião, Fernando; Carvalho, Félix; Sousa, Emília; Bastos, Maria De Lourdes; Costa, Vera M. Autor correspondente: Costa, Vera M. "Comparative in vitro study of the cytotoxic effects of doxorubicin's main metabolites on cardiac AC16 cells versus the parent drug". Cardiovascular Toxicology (2024):
    Aceite para publicação
  7. Carneiro, Patrícia; Ferreira, Mariana; Costa, Vera M; Carvalho, Félix; Capela, João Paulo. "Protective effects of amphetamine and methylphenidate against dopaminergic neurotoxicants in SH-SY5Y cells". Current Research in Toxicology 6 (2024): 100165. http://dx.doi.org/10.1016/j.crtox.2024.100165.
    10.1016/j.crtox.2024.100165
  8. Ferreira, Mariana; Carneiro, Patrícia; Costa, Vera Marisa; Carvalho, Félix; Meisel, Andreas; Capela, João Paulo. "Amphetamine and methylphenidate potential on the recovery from stroke and traumatic brain injury: A review". Reviews in the Neurosciences (2024):
    Submetido
  9. Dias-Carvalho, Ana; Ferreira, Mariana; Reis-Mendes, Ana; Ferreira, Rita; Bastos, Maria de Lourdes; Fernandes, Eduarda; Sá, Susana I; Sá SI; et al. Autor correspondente: Dias-Carvalho, Ana. "Doxorubicin-induced neurotoxicity differently affects the hippocampal formation subregions in adult mice". Heliyon (2024):
    Aceite para publicação
  10. Sara C. Silva-Reis; Correia, Xavier Cruz; Costa-Almeida, Hugo F.; Beatriz L. Pires-Lima; Maronde, DAIANE; Costa, Vera Marisa; García-Mera, Xerardo; et al. Autor correspondente: Ivo E. Sampaio-Dias. "Stapling Amantadine to Melanostatin Neuropeptide: Discovery of Potent Positive Allosteric Modulators of the D2 Receptors". ACS Med. Chem. Lett. (2023): https://doi.org/10.1021/acsmedchemlett.3c00264.
    Publicado
  11. Reis-Mendes, Ana; Carvalho, Félix; Remião, Fernando; Sousa, Emília; de Lourdes Bastos, Maria; Costa, Vera M; Reis-Mendes, A.; et al. Autor correspondente: Costa, Vera M. "Autophagy (but not metabolism) is a key event in mitoxantrone-induced cytotoxicity in differentiated AC16 cardiac cells". Archives of Toxicology 97 1 (2023): 201-216. http://dx.doi.org/10.1007/s00204-022-03363-6.
    Publicado • 10.1007/s00204-022-03363-6
  12. Wu, Dongze; Jin, Yingzhao; Xing, Yuhan; Abate, Melsew Dagne; Abbasian, Mohammadreza; Abbasi-Kangevari, Mohsen; Abbasi-Kangevari, Zeinab; et al. "Global, regional, and national incidence of six major immune-mediated inflammatory diseases: findings from the global burden of disease study 2019". eClinicalMedicine 64 (2023): 102193. http://dx.doi.org/10.1016/j.eclinm.2023.102193.
    Acesso aberto • 10.1016/j.eclinm.2023.102193
  13. Reis-Mendes, Ana; Ferreira, Mariana; Duarte, José Alberto; Duarte-Araújo, Margarida; Remião, Fernando; Carvalho, Félix; Sousa, Emília; Bastos, Maria Lourdes; Costa, Vera M. Autor correspondente: Costa, Vera M. "The role of inflammation and antioxidant defenses in the cardiotoxicity of doxorubicin in elderly CD-1 male mice". Archives of Toxicology 97 12 (2023): 3163-3177. http://dx.doi.org/10.1007/s00204-023-03586-1.
    Publicado • 10.1007/s00204-023-03586-1
  14. Dias-Carvalho, Ana; Margarida-Araújo, Ana; Reis-Mendes, Ana; Sequeira, Catarina Oliveira; Pereira, Sofia Azeredo; Guedes de Pinho, Paula; Carvalho, Félix; et al. Autor correspondente: Costa, Vera M. "A Clinically Relevant Dosage of Mitoxantrone Disrupts the Glutathione and Lipid Metabolic Pathways of the CD-1 Mice Brain: A Metabolomics Study". International Journal of Molecular Sciences 24 17 (2023): 13126. http://dx.doi.org/10.3390/ijms241713126.
    Publicado • 10.3390/ijms241713126
  15. Sousa, Adelaide; Azevedo, Rui; Costa, Vera M; Oliveira, Sara; Preguiça, Inês; Viana, Sofia; Reis, Flávio; et al. "Biodistribution and intestinal inflammatory response following voluntary oral intake of silver nanoparticles by C57BL/6J mice". Archives of Toxicology 97 10 (2023): 2643-2657. http://dx.doi.org/10.1007/s00204-023-03558-5.
    Publicado • 10.1007/s00204-023-03558-5
  16. Brandão, Sofia; Reis-Mendes, Ana; Duarte-Araújo, Margarida; Neuparth, Maria; Rocha, Hugo; Carvalho, Félix; Ferreira, Rita; Costa, Vera M. Autor correspondente: Costa, Vera M. "Cardiac Molecular Remodeling by Anticancer Drugs: Doxorubicin Affects More Metabolism While Mitoxantrone Impacts More Autophagy in Adult CD-1 Male Mice". Biomolecules 13 6 (2023): 921. http://dx.doi.org/10.3390/biom13060921.
    10.3390/biom13060921
  17. Costa, Vera M; Capela, João Paulo; Bastos, Maria Lourdes; Remião, Fernando; Varner, Kurt James; Duarte, José Alberto; Carvalho, Félix; et al. Autor correspondente: Carvalho, Félix. "Study of the potential toxicity of adrenaline to neurons, using the SH-SY5Y human cellular model". Brazilian Journal of Pharmaceutical Sciences 59 (2023): e20467. http://dx.doi.org/10.1590/s2175-97902023e20467.
    Publicado • 10.1590/s2175-97902023e20467
  18. Silva-Reis, Sara C.; Sampaio-Dias, Ivo E.; Costa, Vera M; Correia, Xavier Cruz; Costa-Almeida, Hugo F.; García-Mera, Xerardo; Rodríguez-Borges, José E.. "Concise Overview of Glypromate Neuropeptide Research: From Chemistry to Pharmacological Applications in Neurosciences". ACS Chemical Neuroscience 14 4 (2023): 554-572. http://dx.doi.org/10.1021/acschemneuro.2c00675.
    Publicado • 10.1021/acschemneuro.2c00675
  19. Reis-Mendes, A.; Ferreira, Mariana; Padrão, Ana Isabel; Duarte, Jose Alberto; Duarte-Araújo, M.; Remiao, F.; Carvalho, Félix; et al. Autor correspondente: Costa, Vera M. "The Role of Nrf2 and Inflammation on the Dissimilar Cardiotoxicity of Doxorubicin in Two-Time Points: a Cardio-Oncology In Vivo Study Through Time". Inflammation (2023):
    Aceite para publicação
  20. Costa, Vera M; Grando, Luciana Grazziotin Rossato; Milandri, Elisa; Nardi, Jessica; Teixeira, Patrícia; Mladenka, Premysl; Remião, Fernando. Autor correspondente: Remião, Fernando. "Natural Sympathomimetic Drugs: From Pharmacology to Toxicology". Biomolecules 12 12 (2022): 1793. http://dx.doi.org/10.3390/biom12121793.
    Acesso aberto • Publicado • 10.3390/biom12121793
  21. Remião, Fernando; Carmo, Helena; Gomes, Miguel; Silva, Renata; Costa, Vera Marisa; Carvalho, Félix; Bastos, Maria de Lourdes; et al. Autor correspondente: Remião, Fernando. "The impact of video lecture capture on student attainment and achievement of intended learning outcomes". Pharmacy Education 22 1 (2022): 843-855. http://dx.doi.org/10.46542/pe.2022.221.843855.
    Publicado • 10.46542/pe.2022.221.843855
  22. Brandão, Sofia Reis; Carvalho, Félix; Amado, Francisco; Ferreira, Rita; Costa, Vera M. Autor correspondente: Costa, Vera M. "Insights on the molecular targets of cardiotoxicity induced by anticancer drugs: A systematic review based on proteomic findings". Metabolism 134 (2022): 155250. http://dx.doi.org/10.1016/j.metabol.2022.155250.
    Publicado • 10.1016/j.metabol.2022.155250
  23. Garcia, Juliana; Carvalho, Alexandra; das Neves, Ricardo Pires; Malheiro, Rui; Rodrigues, Daniela F.; Figueiredo, Pedro R.; Bovolini, Antonio; et al. "Antidotal effect of cyclosporine A against a-amanitin toxicity in CD-1 mice, at clinical relevant doses". Food and Chemical Toxicology 166 (2022): 113198. http://dx.doi.org/10.1016/j.fct.2022.113198.
    10.1016/j.fct.2022.113198
  24. Tran, Khanh Bao; Lang, Justin J; Compton, Kelly; Xu, Rixing; Acheson, Alistair R; Henrikson, Hannah Jacqueline; Kocarnik, Jonathan M; et al. "The global burden of cancer attributable to risk factors, 2010–19: a systematic analysis for the Global Burden of Disease Study 2019". The Lancet 400 10352 (2022): 563-591. http://dx.doi.org/10.1016/s0140-6736(22)01438-6.
    Publicado • 10.1016/s0140-6736(22)01438-6
  25. Sharma, Rajesh; Abbasi-Kangevari, Mohsen; Abd-Rabu, Rami; Abidi, Hassan; Abu-Gharbieh, Eman; Acuna, Juan Manuel; Adhikari, Sangeet; et al. "Global, regional, and national burden of colorectal cancer and its risk factors, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019". The Lancet Gastroenterology & Hepatology 7 7 (2022): 627-647. http://dx.doi.org/10.1016/s2468-1253(22)00044-9.
    Publicado • 10.1016/s2468-1253(22)00044-9
  26. Dias-Carvalho, Ana; Ferreira, Mariana; Reis-Mendes, Ana; Ferreira, Rita; Bastos, Maria Lourdes; Fernandes, Eduarda; Sá, Susana Isabel; et al. Autor correspondente: Costa, Vera M. "Chemobrain: mitoxantrone-induced oxidative stress, apoptotic and autophagic neuronal death in adult CD-1 mice". Archives of Toxicology 96 6 (2022): 1767-1782. http://dx.doi.org/10.1007/s00204-022-03261-x.
    Publicado • 10.1007/s00204-022-03261-x
  27. Kocarnik, Jonathan M.; Compton, Kelly; Dean, Frances E.; Fu, Weijia; Gaw, Brian L.; Harvey, James D.; Henrikson, Hannah Jacqueline; et al. "Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life Years for 29 Cancer Groups From 2010 to 2019". JAMA Oncology 8 3 (2022): 420. http://dx.doi.org/10.1001/jamaoncol.2021.6987.
    Publicado • 10.1001/jamaoncol.2021.6987
  28. Nichols, Emma; Steinmetz, Jaimie D; Vollset, Stein Emil; Fukutaki, Kai; Chalek, Julian; Abd-Allah, Foad; Abdoli, Amir; et al. "Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: an analysis for the Global Burden of Disease Study 2019". The Lancet Public Health 7 2 (2022): e105-e125. http://dx.doi.org/10.1016/s2468-2667(21)00249-8.
    Publicado • 10.1016/s2468-2667(21)00249-8
  29. Moreira-Pais, Alexandra; Ferreira, Rita; Costa, Vera; Oliveira P.; Duarte, José Alberto. "The molecular mechanisms involved in doxorubicin-induced skeletal muscle wasting". Revista Portuguesa de Cirurgia 51 (2022): 13-22.
    Publicado • 10.34635/rpc.930
  30. Dionísio, Flávio; Araújo, Ana Margarida; Duarte-Araújo, Margarida; Bastos, Maria de Lourdes; Guedes de Pinho, Paula; Carvalho, Félix; Costa, Vera Marisa. Autor correspondente: Costa, Vera Marisa. "Cardiotoxicity of cyclophosphamide’s metabolites: an in vitro metabolomics approach in AC16 human cardiomyocytes". Archives of Toxicology 96 2 (2022): 653-671. http://dx.doi.org/10.1007/s00204-021-03204-y.
    10.1007/s00204-021-03204-y
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  87. Reis-Mendes, A.; Gomes, A. S.; Carvalho, R. A.; Carvalho, F.; Remião, F.; Pinto, M.; Bastos, M. L.; Sousa, E.; Costa, V. M.. "Naphthoquinoxaline metabolite of mitoxantrone is less cardiotoxic than the parent compound and it can be a more cardiosafe drug in anticancer therapy". Archives of Toxicology 91 4 (2016): 1871-1890. http://dx.doi.org/10.1007/s00204-016-1839-z.
    10.1007/s00204-016-1839-z
  88. Teixeira-Gomes, Armanda; Costa, Vera Marisa; Feio-Azevedo, Rita; Duarte, José Alberto; Duarte-Araújo, Margarida; Fernandes, Eduarda; Bastos, Maria de Lourdes; Carvalho, Félix; Capela, João Paulo. "Ecstasy toxicity to adolescent rats following an acute low binge dose". BMC Pharmacology and Toxicology 17 1 (2016): http://dx.doi.org/10.1186/s40360-016-0070-0.
    10.1186/s40360-016-0070-0
  89. Couto, Diana; Freitas, Marisa; Costa, Vera Marisa; Chisté, Renan Campos; Almeida, Agostinho; Lopez-Quintela, M. Arturo; Rivas, José; et al. "Biodistribution of polyacrylic acid-coated iron oxide nanoparticles is associated with proinflammatory activation and liver toxicity". Journal of Applied Toxicology 36 10 (2016): 1321-1331. http://dx.doi.org/10.1002/jat.3323.
    10.1002/jat.3323
  90. Filipa Reis-Mendes, Ana; Sousa, Emília; de Lourdes Bastos, Maria; Marisa Costa, Vera. "The Role of the Metabolism of Anticancer Drugs in Their Induced-Cardiotoxicity". Current Drug Metabolism 17 1 (2015): 75-90. http://dx.doi.org/10.2174/1389200216666151103114926.
    10.2174/1389200216666151103114926
  91. Garcia, Juliana; Costa, Vera M.; Carvalho, Alexandra; Baptista, Paula; de Pinho, Paula Guedes; de Lourdes Bastos, Maria; Carvalho, Félix. "Amanita phalloides poisoning: Mechanisms of toxicity and treatment". Food and Chemical Toxicology 86 (2015): 41-55. http://dx.doi.org/10.1016/j.fct.2015.09.008.
    Publicado • 10.1016/j.fct.2015.09.008
  92. Garcia, Juliana; Costa, Vera Marisa; Carvalho, Alexandra T. P.; Silvestre, Ricardo; Duarte, José Alberto; Dourado, Daniel F. A. R.; Arbo, Marcelo D.; et al. "A breakthrough on Amanita phalloides poisoning: an effective antidotal effect by polymyxin B". Archives of Toxicology 89 12 (2015): 2305-2323. http://dx.doi.org/10.1007/s00204-015-1582-x.
    Publicado • 10.1007/s00204-015-1582-x
  93. Garcia, Juliana; Costa, Vera M.; Costa, Ana Elisa; Andrade, Sérgio; Carneiro, Ana Cristina; Conceição, Filipe; Paiva, José Artur; et al. "Co-ingestion of amatoxins and isoxazoles-containing mushrooms and successful treatment: A case report". Toxicon 103 (2015): 55-59. http://dx.doi.org/10.1016/j.toxicon.2015.06.012.
    Publicado • 10.1016/j.toxicon.2015.06.012
  94. Garcia, Juliana; Costa, Vera M.; Baptista, Paula; Bastos, Maria de Lourdes; Carvalho, Félix. "Quantification of alpha-amanitin in biological samples by HPLC using simultaneous UV- diode array and electrochemical detection". Journal of Chromatography B 997 (2015): 85-95. http://dx.doi.org/10.1016/j.jchromb.2015.06.001.
    10.1016/j.jchromb.2015.06.001
  95. Dores-Sousa, José Luís; Duarte, José Alberto; Seabra, Vítor; Bastos, Maria de Lourdes; Carvalho, Félix; Costa, Vera Marisa. "The age factor for mitoxantrone's cardiotoxicity: Multiple doses render the adult mouse heart more susceptible to injury". Toxicology 329 (2015): 106-119. http://dx.doi.org/10.1016/j.tox.2015.01.006.
    Publicado • 10.1016/j.tox.2015.01.006
  96. Teixeira-Gomes, Armanda; Costa, Vera Marisa; Feio-Azevedo, Rita; Bastos, Maria de Lourdes; Carvalho, Félix; Capela, João Paulo. "The neurotoxicity of amphetamines during the adolescent period". International Journal of Developmental Neuroscience 41 1 (2014): 44-62. http://dx.doi.org/10.1016/j.ijdevneu.2014.12.001.
    10.1016/j.ijdevneu.2014.12.001
  97. Nogueira, T.B.; da Costa Araújo, S.; Carvalho, F.; Pereira, F.C.; Fernandes, E.; Bastos, M.L.; Costa, V.M.; Capela, J.P.. "Modeling chronic brain exposure to amphetamines using primary rat neuronal cortical cultures". Neuroscience 277 (2014): 417-434. http://dx.doi.org/10.1016/j.neuroscience.2014.07.009.
    10.1016/j.neuroscience.2014.07.009
  98. Soares, Ana S.; Costa, Vera M.; Diniz, Carmen; Fresco, Paula. "The combination of Cl-IB-MECA with paclitaxel: a new anti-metastatic therapeutic strategy for melanoma". Cancer Chemotherapy and Pharmacology 74 4 (2014): 847-860. http://dx.doi.org/10.1007/s00280-014-2557-y.
    10.1007/s00280-014-2557-y
  99. Soares, Ana Sofia; Costa, Vera Marisa; Diniz, Carmen; Fresco, Paula. "Inosine Strongly Enhances Proliferation of Human C32 Melanoma Cells through PLC-PKC-MEK1/2-ERK1/2 and PI3K Pathways". Basic & Clinical Pharmacology & Toxicology 116 1 (2014): 25-36. http://dx.doi.org/10.1111/bcpt.12280.
    10.1111/bcpt.12280
  100. Soares, Ana S.; Costa, Vera M.; Diniz, Carmen; Fresco, Paula. "Combination of Cl-IB-MECA with paclitaxel is a highly effective cytotoxic therapy causing mTOR-dependent autophagy and mitotic catastrophe on human melanoma cells". Journal of Cancer Research and Clinical Oncology 140 6 (2014): 921-935. http://dx.doi.org/10.1007/s00432-014-1645-z.
    10.1007/s00432-014-1645-z
  101. Feio-Azevedo, Rita; Costa, Vera Marisa; Ferreira, Luisa Pinto; Branco, Paula Serio; Pereira, Frederico Costa; Bastos, Maria de Lourdes; Carvalho, Felix; Capela, Joao Paulo. "Amphetamine and its metabolite 4-hydroxyamphetamine neurotoxicity in differentiated SH-SY5Y neurons". Toxicology Letters 229 (2014): S241-S241. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000341134000754&KeyUID=WOS:000341134000754.
    10.1016/j.toxlet.2014.06.805
  102. Reis-Mendes, Ana; Sousa, Emelia; Remiao, Fernando; Carvalho, Felix; Bastos, Maria Lourdes; Costa, Vera Marisa. "At pharmacology relevant concentrations, mitoxantrone causes time- and concentration-dependent toxicity in H9c2 differentiated cells with autophagy involvement". Toxicology Letters 229 (2014): S246-S246. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000341134000768&KeyUID=WOS:000341134000768.
    10.1016/j.toxlet.2014.06.819
  103. Rossato, Luciana G.; Costa, Vera M.; Dallegrave, Eliane; Arbo, Marcelo; Dinis-Oliveira, Ricardo J.; Santos-Silva, Alice; Duarte, José A.; et al. "Cumulative Mitoxantrone-Induced Haematological and Hepatic Adverse Effects in a SubchronicIn vivoStudy". Basic & Clinical Pharmacology & Toxicology 114 3 (2013): 254-262. http://dx.doi.org/10.1111/bcpt.12143.
    10.1111/bcpt.12143
  104. Rossato, Luciana Grazziotin; Costa, Vera Marisa; Dallegrave, Eliane; Arbo, Marcelo; Silva, Renata; Ferreira, Rita; Amado, Francisco; et al. "Mitochondrial Cumulative Damage Induced by Mitoxantrone: Late Onset Cardiac Energetic Impairment". Cardiovascular Toxicology 14 1 (2013): 30-40. http://dx.doi.org/10.1007/s12012-013-9230-2.
    Publicado • 10.1007/s12012-013-9230-2
  105. Soares, Ana S.; Costa, Vera M.; Diniz, Carmen; Fresco, Paula. "Potentiation of cytotoxicity of paclitaxel in combination with Cl-IB-MECA in human C32 metastatic melanoma cells: A new possible therapeutic strategy for melanoma". Biomedicine & Pharmacotherapy 67 8 (2013): 777-789. http://dx.doi.org/10.1016/j.biopha.2013.08.003.
    10.1016/j.biopha.2013.08.003
  106. Rossato, Luciana Grazziotin; Costa, Vera Marisa; Vilas-Boas, Vânia; de Lourdes Bastos, Maria; Rolo, Anabela; Palmeira, Carlos; Remião, Fernando. "Therapeutic Concentrations of Mitoxantrone Elicit Energetic Imbalance in H9c2 Cells as an Earlier Event". Cardiovascular Toxicology 13 4 (2013): 413-425. http://dx.doi.org/10.1007/s12012-013-9224-0.
    10.1007/s12012-013-9224-0
  107. Costa, Vera Marisa; Carvalho, Félix; Duarte, José Alberto; Bastos, Maria de Lourdes; Remião, Fernando. "The Heart As a Target for Xenobiotic Toxicity: The Cardiac Susceptibility to Oxidative Stress". Chemical Research in Toxicology 26 9 (2013): 1285-1311. http://dx.doi.org/10.1021/tx400130v.
    10.1021/tx400130v
  108. Freitas, Marisa; Costa, Vera M.; Ribeiro, Daniela; Couto, Diana; Porto, Graça; Carvalho, Félix; Fernandes, Eduarda. "Acetaminophen prevents oxidative burst and delays apoptosis in human neutrophils". Toxicology Letters 219 2 (2013): 170-177. http://dx.doi.org/10.1016/j.toxlet.2013.03.007.
    10.1016/j.toxlet.2013.03.007
  109. Rossato, Luciana Grazziotin; Costa, Vera Marisa; de Pinho, Paula Guedes; Arbo, Marcelo Dutra; de Freitas, Victor; Vilain, Laure; de Lourdes Bastos, Maria; Palmeira, Carlos; Remião, Fernando. "The metabolic profile of mitoxantrone and its relation with mitoxantrone-induced cardiotoxicity". Archives of Toxicology 87 10 (2013): 1809-1820. http://dx.doi.org/10.1007/s00204-013-1040-6.
    Publicado • 10.1007/s00204-013-1040-6
  110. Capela, João Paulo; da Costa Araújo, Silvana; Costa, Vera Marisa; Ruscher, Karsten; Fernandes, Eduarda; Bastos, Maria de Lourdes; Dirnagl, Ulrich; Meisel, Andreas; Carvalho, Félix. "The neurotoxicity of hallucinogenic amphetamines in primary cultures of hippocampal neurons". NeuroToxicology 34 (2013): 254-263. http://dx.doi.org/10.1016/j.neuro.2012.09.005.
    10.1016/j.neuro.2012.09.005
  111. Ferreira, P.S.; Nogueira, T.B.; Costa, V.M.; Branco, P.S.; Ferreira, L.M.; Fernandes, E.; Bastos, M.L.; et al. "Neurotoxicity of "ecstasy" and its metabolites in human dopaminergic differentiated SH-SY5Y cells". Toxicology Letters 216 2-3 (2013): 159-170. http://www.scopus.com/inward/record.url?eid=2-s2.0-84871546317&partnerID=MN8TOARS.
    10.1016/j.toxlet.2012.11.015
  112. Carvalho, Márcia; Carmo, Helena; Costa, Vera Marisa; Capela, João Paulo; Pontes, Helena; Remião, Fernando; Carvalho, Félix; Bastos, Maria de Lourdes. "Toxicity of amphetamines: an update". Archives of Toxicology 86 8 (2012): 1167-1231. http://dx.doi.org/10.1007/s00204-012-0815-5.
    Publicado • 10.1007/s00204-012-0815-5
  113. M. Costa, V.; Carvalho, F.; L. Bastos, M.; A. Carvalho, R.; Carvalho, M.; Remiao, F.. "Contribution of Catecholamine Reactive Intermediates and Oxidative Stress to the Pathologic Features of Heart Diseases". Current Medicinal Chemistry 18 15 (2011): 2272-2314. http://dx.doi.org/10.2174/092986711795656081.
    10.2174/092986711795656081
  114. Rossato, Luciana Grazziotin; Costa, Vera Marisa; Limberger, Renata Pereira; Bastos, Maria de Lourdes; Remião, Fernando. "Synephrine: From trace concentrations to massive consumption in weight-loss". Food and Chemical Toxicology 49 1 (2011): 8-16. http://dx.doi.org/10.1016/j.fct.2010.11.007.
    10.1016/j.fct.2010.11.007
  115. Costa, Vera M; Bastos, Maria de Lourdes; Carvalho, Félix; Costa, Vera Marisa; Carvalho, Félix. "Género masculino vs. feminino: factor relevante para as respostas farmacológicas e efeitos adversos de fármacos?". Acta Farmacêutica Portuguesa 1 1 (2011): 55-64. http://www.actafarmaceuticaportuguesa.com/index.php/afp/article/view/32.
    Publicado
  116. Rossato, Luciana Grazziotin; Costa, Vera Marisa; de Pinho, Paula Guedes; Carvalho, Félix; de Lourdes Bastos, Maria; Remião, Fernando. "Structural isomerization of synephrine influences its uptake and ensuing glutathione depletion in rat-isolated cardiomyocytes". Archives of Toxicology 85 8 (2010): 929-939. http://dx.doi.org/10.1007/s00204-010-0630-9.
    10.1007/s00204-010-0630-9
  117. Rossato, Luciana Grazziotin; de Pinho, Paula Guedes; Silva, Renata; Carmo, Helena; Carvalho, Félix; Bastos, Maria de Lourdes; Costa, Vera Marisa; Remião, Fernando. "Development and validation of a GC/IT-MS method for simultaneous quantitation of para and meta-synephrine in biological samples". Journal of Pharmaceutical and Biomedical Analysis 52 5 (2010): 721-726. http://dx.doi.org/10.1016/j.jpba.2010.02.022.
    10.1016/j.jpba.2010.02.022
  118. Oliveira, Susana J.; Pinto, Jorge P.; Picarote, Gonçalo; Costa, Vera M.; Carvalho, Félix; Rangel, Maria; de Sousa, Maria; de Almeida, Sérgio F.. "ER Stress-Inducible Factor CHOP Affects the Expression of Hepcidin by Modulating C/EBPalpha Activity". PLoS ONE 4 8 (2009): e6618. http://dx.doi.org/10.1371/journal.pone.0006618.
    10.1371/journal.pone.0006618
  119. Costa, Vera Marisa; Silva, Renata; Tavares, Ludgero Canário; Vitorino, Rui; Amado, Francisco; Carvalho, Félix; Bastos, Maria de Lourdes; et al. "Adrenaline and reactive oxygen species elicit proteome and energetic metabolism modifications in freshly isolated rat cardiomyocytes". Toxicology 260 1-3 (2009): 84-96. http://dx.doi.org/10.1016/j.tox.2009.03.012.
    10.1016/j.tox.2009.03.012
  120. Costa, Vera Marisa; Silva, Renata; Ferreira, Rita; Amado, Francisco; Carvalho, Félix; de Lourdes Bastos, Maria; Carvalho, Rui Albuquerque; Carvalho, Márcia; Remião, Fernando. "Adrenaline in pro-oxidant conditions elicits intracellular survival pathways in isolated rat cardiomyocytes". Toxicology 257 1-2 (2009): 70-79. http://dx.doi.org/10.1016/j.tox.2008.12.010.
    10.1016/j.tox.2008.12.010
  121. Costa, Vera Marisa; Ferreira, Lui´sa Maria; Branco, Paula Se´rio; Carvalho, Fe´lix; Bastos, Maria Lourdes; Carvalho, Rui Albuquerque; Carvalho, Ma´rcia; Remia~o, Fernando. "Cross-Functioning between the Extraneuronal Monoamine Transporter and Multidrug Resistance Protein 1 in the Uptake of Adrenaline and Export of 5-(Glutathion-S-yl)adrenaline in Rat Cardiomyocytes". Chemical Research in Toxicology 22 1 (2009): 129-135. http://dx.doi.org/10.1021/tx8002577.
    10.1021/tx8002577
  122. Costa, Vera Marisa; Silva, Renata; Ferreira, Luísa Maria; Branco, Paula Sério; Carvalho, Félix; Bastos, Maria Lourdes; Carvalho, Rui Albuquerque; Carvalho, Márcia; Remião, Fernando. "Oxidation Process of Adrenaline in Freshly Isolated Rat Cardiomyocytes: Formation of Adrenochrome, Quinoproteins, and GSH Adduct". Chemical Research in Toxicology 20 8 (2007): 1183-1191. http://dx.doi.org/10.1021/tx7000916.
    10.1021/tx7000916
  123. Silva, R.; Boldt, S.; Costa, V.M.; Carmo, H.; Carvalho, M.; Carvalho, F.; Bastos, M. de L.; Lemos-Amado, F.; Remião, F.. "Evaluation of GSH adducts of adrenaline in biological samples". Biomedical Chromatography 21 7 (2007): 670-679. http://www.scopus.com/inward/record.url?eid=2-s2.0-34447504376&partnerID=MN8TOARS.
    10.1002/bmc.796
  124. Costa, Vera; Carvalho, Marcia; Carvalho, Felix; Bastos, Maria Lourdes; Carvalho, Rui; Remiao, Fernando. "Effect of adrenaline and oxygen free radicals on calcium tolerant cardiomyocytes: Formation of glutathione adducts". Toxicology Letters 164 (2006): S130-S131. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000240407200267&KeyUID=WOS:000240407200267.
    10.1016/j.toxlet.2006.06.274
Capítulo de livro
  1. Costa, Vera M; Carvalho, Félix; Seabra, Vítor. "Metais e Metalóides". In Toxicologia Alimentar, editado por Oliveira, Nuno G.; Carvalho, Félix; Dinis, Ricardo. Portugal: Lidel, 2023.
    Submetido
  2. Costa, Vera M; Carvalho, Ana Rita; Capela, João Paulo; Carvalho, Félix. Autor correspondente: Costa, Vera M. "Chemobrain". In Toxicological Risk Assessment and Multi-System Health Impacts from Exposure, editado por Aristides Tsatsakis, 62-72. Países Baixos: Elsevier Editions, 2021.
    Publicado
  3. Costa, Vera M; Remião, Fernando; Carvalho, Félix Dias; Dinis-Oliveira, Ricardo Jorge; Bastos, Maria Bastos. "O coração como órgão alvo da toxicidade de xenobióticos". In Toxicologia Fundamental. 2018.
  4. Costa, Vera M; Seabra, Vítor. "Metais com Interesse Forense". In Toxicologia Forense, editado por Carvalho, Félix Dias; Bastos, Maria de Lourdes; REQUIMTE - Laboratório de Toxologia, Departamento de Ciências Biológicas, Faculdade de Farmáci; Dinis-Oliveira, Ricardo Jorge. Portugal: Edições Lidel/Pactor, 2015.
  5. Costa, Vera M; Carvalho, Félix Dias; Bastos, Maria De Lourdes; Carvalho, Rui Albuquerque; Carvalho, Marcia; Remião, Fernando. "Adrenaline and noradrenaline: partners and actors in the same play. Adrenaline and Noradrenaline: Partners and Actors in the Same Play". In Neuroscience - Dealing With Frontiers, editado por Contreras, Carlos. InTech, 2012.
Edição de número de revista
  1. Costa, Vera M; Carvalho, Félix. "Pharmacology of Cardiovascular Disease". Biomolecules (2023): https://www.mdpi.com/journal/biomolecules/special_issues/Pharmacology-Cardiovascular.
    No prelo • Editor convidado
  2. Capela, João Paulo; Costa, Vera Marisa. "Pharmacology and Toxicology of Amphetamine Type Stimulants". Future Pharmacolgy (2023):
    Aceite para publicação • Editor convidado
  3. Costa, Vera; Battal, Dilek ; Ziulkoski, Ana Luiza ; Amos, Samson ; Moon, Yuseok ; Venosa, Alessandro ; Feliu, Neus; et al. "Emerging Talents in Toxicology: Clinical Toxicology". Frontiers in Toxicology (2023):
    Submetido • Editor convidado
  4. Costa, Vera M. "Current Frames on Cardiotoxicology of New and Old Anticancer Drugs". Pharmaceuticals (2023):
    Submetido • Editor convidado
Entrada de enciclopédia
  1. Costa, Vera M; Rossato, Luciana G.; Milandri, Elisa; Nardi, Jessica; Teixeira, Patrícia; Mladenka, Premysl; Remião, Fernando. "Trace amines". In Scholarly Community Encyclopedia, 2022.
    Publicado
Poster em conferência
  1. Luís, Cláudia; Vitorino-Oliveira, Cláudia; Gaspar, Helena; Carvalho, Félix; Capela, João Paulo; Costa, Vera Marisa. Autor correspondente: Luís, Cláudia. "Synthetic Cathinones vs Methamphetamine: A Comparative In Vitro Cytotoxicity Study on Cardiac AC16 Cells". Trabalho apresentado em IX Edição das Jornadas da Bioquímica do NEBQUP, 2024.
  2. Dias-Carvalho, Ana; Araújo, Ana Margarida; Reis-Mendes, A.; Sequeira, CO; Pereira, AS; Guedes de Pinho, Paula; Carvalho, Félix; et al. "Chemobrain: exploring the impact of a clinically relevant dose of mitoxantrone in the metabolic profile of CD-1 mice brain". Trabalho apresentado em EMBO Young Scientists¿ Forum (Lisbon), 2023.
  3. Vitorino-Oliveira, Cláudia; Kahremany, Shirin; Nissim, Laura; Duarte-Araújo, Margarida; Carvalho, Félix; Gruzman, Arie; Costa, Vera Marisa. Autor correspondente: Vitorino-Oliveira, Cláudia. "A citotoxicidade do sunitinib, da doxorrubicina e do bortezomib nas células AC16 e possíveis terapias envolvendo as vias redox". Trabalho apresentado em 5º Encontro Nacional de Jovens Investigadores em Oncologia, 2023.
  4. Vitorino-Oliveira, Cláudia; Kahremany, Shirin; Nissim, Laura; Duarte-Araújo, Margarida; Carvalho, Félix; Gruzman, Arie; Costa, Vera Marisa. Autor correspondente: Vitorino-Oliveira, Cláudia. "The cytotoxicity of sunitinib, doxorubicin and bortezomib in AC16 cardiac cells and possible therapeutic oprtions involving redox pathways". Trabalho apresentado em 18th YES Meeting, 2023.
  5. Sara C. Silva-Reis; Ivo E. Sampaio-Dias; Correia da Silva, Daniela; Correia, Xavier Cruz; Costa-Almeida, Hugo F.; Beatriz L. Pires-Lima; Costa, Vera M; et al. Autor correspondente: Sara C. Silva-Reis. "Exploring the biological impact of proline residue on Glypromate bioconjugates". Trabalho apresentado em MedChem 2023, 2023.
  6. Ivo E. Sampaio-Dias; Maronde, DAIANE; Sara C. Silva-Reis; Correia, Xavier Cruz; Costa-Almeida, Hugo F.; Beatriz L. Pires-Lima; Costa, Vera M; García-Mera, Xerardo; J. E. Rodriguez-Borges. Autor correspondente: Ivo E. Sampaio-Dias. "Exploring the Lipophilic Bullet Approach in Melanostatin Neuropeptide". Trabalho apresentado em IX SEQT Symposium of Medicinal Chemistry Young Researchers, 2023.
  7. Adelaide Sousa; Rui Azevedo; Costa, Vera M; Sara Oliveira; Inês Preguiça; Sofia Viana; Flávio Reis; et al. "Impact of dietary exposure to silver nanoparticles on the intestinal inflammatory response in C57BL/6J mice". Trabalho apresentado em 12th International Symposium on Biological Monitoring in Occupational and Environmental Health, 2023.
  8. Sofia R, Brandão; Oliveira, Paula; Carvalho, Félix; Ferreira, Rita; Costa, Vera Marisa. "Doxorubicin induced mitochondrial adaptation on female Wistar rats with mammary carcinogenesis". Trabalho apresentado em MitoPorto 2023 - Mitochondrial physiology, redox biology, and genetics, 2023.
  9. Vitorino-Oliveira, Cláudia; Kahremany, Shirin; Nissim, Laura; Duarte-Araújo, Margarida; Carvalho, Félix; Costa, Vera Marisa. Autor correspondente: Costa, Vera Marisa. "The influence of oxidative stress modulators on the cytotoxicity of sunitinib, doxorubicin and bortezomib in AC16 cardiac cells". Trabalho apresentado em VIII Jornadas da Bioquímica, 2023.
  10. Beatriz L. Pires-Lima; Sara C. Silva-Reis; Correia, Xavier Cruz; Costa-Almeida, Hugo F.; Costa, Vera M; García-Mera, Xerardo; J. E. Rodriguez-Borges; Ivo E. Sampaio-Dias. "Using Proline Bioisosteres for the Assembly of Potent Melanostatin (MIF-1) Analogues". Trabalho apresentado em ENEQUI - Encontro Nacional de Estudantes de Química, 2023.
  11. Sara C. Silva-Reis; Ivo E. Sampaio-Dias; da Silva, Daniela Correia; Correia, Xavier Cruz; Costa-Almeida, Hugo F.; Beatriz L. Pires-Lima; Costa, Vera Marisa; et al. "Discovery of Glypromate Conjugates with Biomedical Applications in Alzheimeir's Disease". Trabalho apresentado em 2nd Symposium on Alzheimer's Disease, 2023.
  12. Ivo E. Sampaio-Dias; Sara C. Silva-Reis; Reis-Mendes, Ana; Correia, Xavier Cruz; Costa-Almeida, Hugo F.; Beatriz L. Pires-Lima; Costa, Vera M; García-Mera, Xerardo; J. E. Rodriguez-Borges. Autor correspondente: Ivo E. Sampaio-Dias. "Application of 2-azanorbornane for the assembly of bioactive peptidomimetics". Trabalho apresentado em MedChem 2023, 2023.
  13. Sara C. Silva-Reis; Ivo E. Sampaio-Dias; Costa, Vera M; Correia da Silva, Daniela; Pereira, David M.; Correia, Xavier Cruz; Costa-Almeida, Hugo F.; et al. Autor correspondente: Sara C. Silva-Reis. "Unraveling the role of Proline on the Biological activity of Glypromate Bioconjugates". Trabalho apresentado em IX Symposium of Medicinal Chemistry Young Researchers, 2023.
  14. Beatriz L. Pires-Lima; Sara C. Silva-Reis; Correia, Xavier Cruz; Costa-Almeida, Hugo F.; Costa, Vera M; García-Mera, Xerardo; J. E. Rodriguez-Borges. Autor correspondente: Beatriz L. Pires-Lima. "Pyridine-Based Melanostatin Bioisoteres As Positive Allosteric Modulators Of The Dopamine D2 Receptors". Trabalho apresentado em IX Symposium of Medicinal Chemistry Young Researchers, 2023.
  15. Costa-Almeida, Hugo F.; Sara C. Silva-Reis; Correia, Xavier Cruz; Beatriz L. Pires-Lima; Costa, Vera M; García-Mera, Xerardo; J. E. Rodriguez-Borges; Ivo E. Sampaio-Dias. Autor correspondente: Costa-Almeida, Hugo F.. "Exploring The Impact Of Proline Puckering On The Modulatory Activity Of Melanostatin Neuropeptide". Trabalho apresentado em IX Symposium of Medicinal Chemistry Young Researchers, 2023.
  16. Sara C. Silva-Reis; Ivo E. Sampaio-Dias; Costa, Vera Marisa; Correia, Xavier Cruz; Costa-Almeida, Hugo F.; García-Mera, Xerardo; José Enrique Rodriguez Borges. Autor correspondente: Sara C. Silva-Reis. "Design, Synthesis, and Biological Evaluation of Glypromate-Based Neuroprotective Conjugates with Pharmaceutical Active Ingredients". Trabalho apresentado em Congreso Internacional: XXVI Encontro Galego-Portugués de Química, 2022.
  17. Brandão, Sofia Reis; Filipa Reis-Mendes, Ana; Duarte-Araújo, M.; Rocha, Hugo; Neuparth, Maria João; Carvalho, Félix; Ferreira, Rita; Costa, Vera M. "Cardiac metabolic adaptation after doxorubicin and mitoxantrone on adult mice". Trabalho apresentado em 1st Conference of the Doctoral Program Metabolism – Clinical and Experimental, The prism of Diabesity: looking by a different perspective, 2022.
  18. Sara C. Silva-Reis; Ivo E. Sampaio-Dias; Costa, Vera Marisa; Correia, Xavier Cruz; Hugo F. Costa-Almeida; García-Mera, Xerardo; José Enrique Rodriguez Borges. "Peptide-amine Conjugates targeting Neurodegenerative Diseases". Trabalho apresentado em XX National Meeting of the Spanish Society of Medicinal Chemistry (SEQT), 2022.
  19. Sara C. Silva-Reis; Ivo E. Sampaio-Dias; Costa, Vera Marisa; Correia, Xavier Cruz; Costa-Almeida, Hugo F.; García-Mera, Xerardo; José Enrique Rodriguez Borges. "Application of Hybrid Glypromate® Conjugates in Neurodegenerative Diseases". Trabalho apresentado em Encontro Ciência 2022, 2022.
  20. Moreira-Pais, Alexandra; Baltazar, Telmo; Mendes, Ana-Reis; Oliveira, Paula A.; Costa, Vera Marisa; Ferreira, Rita; Duarte, José A.. Autor correspondente: Moreira-Pais, Alexandra. "Long-term effect of doxorubicin on skeletal muscle oxidative stress in aged mice". Trabalho apresentado em Ciência 2022 - Encontro com a Ciência e Tecnologia em Portugal, 2022.
  21. Rodrigues, Patrícia; Sofia R, Brandão; Ferreira, Rita; Costa, Vera Marisa. "Impacto da quimioterapia com mitoxantrona na regeneração cardíaca". Trabalho apresentado em XIII Biochemistry Day - The Biochemistry of The Mood, 2022.
  22. Sofia R, Brandão; Reis-Mendes, Ana; Duarte-Araújo, Margarida; Neuparth, Maria João; Carvalho, Félix; Ferreira, Rita; Costa, Vera Marisa. "Unveiling the chronic cardiotoxic effects of doxorubicin on cardiac remodeling using a mouse model". Trabalho apresentado em Ciência 2022 – Science and Technology in Portugal Summit, 2022.
  23. Ferreira, Mariana; Dias-Carvalho, Ana; Reis-Mendes, Ana; Ferreira, Rita; Fernandes, Eduarda; Sá, Susana I; Sá SI; Capela, João Paulo; Carvalho, Félix; Costa, Vera Marisa. "Evaluation of mitoxantrone neurotoxicity in CD-1 mice: A chemobrain study". Trabalho apresentado em AIMS Meeting, 2022.
  24. Sofia R, Brandão; Reis-Mendes, Ana; Duarte-Araújo, Margarida; Neuparth, Maria João; Carvalho, Félix; Ferreira, Rita; Costa, Vera Marisa. "Agravamento tardio dos efeitos moleculares subjacentes a cardiotoxicidade crónica da doxorrubicina num modelo de murganho". Trabalho apresentado em 3rd National Meeting of Young Researchers on Oncology (III ENJIO), 2021.
  25. Dias-Carvalho, Ana; Ferreira, Mariana; Fernandes, Ana; Reis-Mendes, Ana; Araújo, Ana Margarida; Ferreira, Rita; Carvalho, Félix; et al. "A neurotoxicidade de longo prazo da doxorrubicina no cérebro de ratinhos CD-1 adultos.". Trabalho apresentado em 3º Encontro Nacional de Jovens Investigadores em Oncologia, Porto, Portugal, 2021.
  26. Serras, Ana S; Camões, Sérgio P; Antunes, Bernardo; Dionísio, F; Costa, Vera M; Yazar, Volkan; Vitorino, R; et al. "The secretome of mesenchymal stem cells ameliorates the cytotoxic effects of doxorubicin in non-tumoral cells". Trabalho apresentado em EUROTOX 2021 ¿ 56th Congress of the European Societies of Toxicology, 2021.
  27. Sara C. Silva-Reis; Ivo E. Sampaio-Dias; Costa, Vera Marisa; Beatriz L. Pires-Lima; Correia, Xavier Cruz; Hugo F. Costa-Almeida; García-Mera, Xerardo; J. E. Rodriguez-Borges. Autor correspondente: Ivo E. Sampaio-Dias. "The design of New Trofinetide® Conjugates Using Constrained Prolines". Trabalho apresentado em Encontro Nacional da Sociedade Portuguesa de Química, 2021.
  28. Dias-Carvalho, Ana; Ferreira, Mariana; Fernandes, Ana; Reis-Mendes, Ana; Araújo, Ana Margarida; Ferreira, Rita; Carvalho, Félix; et al. Autor correspondente: Dias-Carvalho, Ana. "The neurotoxicity of doxorubicin in the brain of adult CD-1 mice". Trabalho apresentado em Ciência 2021 ¿ Science and Technology in Portugal Summit, Lisbon, Portugal, 2021.
  29. Serras, Ana S.; Camões, Sérgio P.; Antunes, Bernardo C.; Dionísio, F; Costa, Vera M; Yazar, Volkan; Vitorino, R; et al. "The Mesenchymal Stem Cells Secretome Modulates Doxorubicin-induced Effects on Non-tumour Breast and Cardiac Cells". Trabalho apresentado em iMed.ULisboa meeting 2021, 2021.
  30. Sofia R, Brandão; Reis-Mendes, Ana; Duarte-Araújo, Margarida; Neuparth, Maria João; Carvalho, Félix; Costa, Vera Marisa. "Unveiling the effects of doxorubicin and mitoxantrone on cardiac metabolism, homeostasis and autophagy in a mice model". Trabalho apresentado em III Iberian Journeys of Toxicology (III JIT), 2021.
  31. Sofia R, Brandão; Reis-Mendes, Ana; Duarte-Araújo, Margarida; Neuparth, Maria João; Carvalho, Félix; Ferreira, Rita; Costa, Vera Marisa. "Disclosing the cardiotoxic effects of the anticancer agentes doxorubicin and mitoxantrone on cardiac metabolism, homeostasis and autophagy using CD-1 mice". Trabalho apresentado em Ciência 2021 – Science and Technology in Portugal Summit, 2021.
  32. Ferreira, Mariana; Dias-Carvalho, Ana; Reis-Mendes, Ana; Carvalho, Félix; Ferreira, Rita; Costa, Vera. "Evaluation of doxorubicin and mitoxantrone neurotoxicity in CD-1 mice: A chemobrain study". Trabalho apresentado em 14th Meeting of young researches of U. Porto (IJUP ¿21), 2021.
  33. Dias-Carvalho, Ana; Fernandes, Ana Olivía ; Reis-Mendes, Ana; Duarte-Araújo, Margarida; Carvalho, Félix; Capela, João Paulo; Sá, Susana Isabel; Costa, Vera Marisa. "Chemobrain: assessing the potential to recovery from doxorubicin-induced-neurotoxic effects in CD-1 mice". Trabalho apresentado em 14º Encontro de Investigação Jovem da U. Porto (IJUP ¿21), 2021.
  34. Reis-Mendes, Ana; ESPINCHO, FRANCISCA; Margarida Duarte-Araújo; Duarte, José Alberto; Remião, Fernando; Emilia Sousa; Bastos, Maria de Lourdes; Carvalho, Félix; Costa, Vera Marisa. Autor correspondente: ESPINCHO, FRANCISCA. "Short-term and long term renal and hepatic toxicity of doxorubicin". Trabalho apresentado em 14º Encontro de Investigação Jovem da Universidade do Porto, 2021.
  35. Ferreira, Mariana; Dias-Carvalho, Ana; Reis-Mendes, Ana; Carvalho, Félix; Ferreira, Rita; Costa, Vera. "Doxorubicin and mitoxantrone neurotoxicity in CD-1 mice: A chemobrain study". Trabalho apresentado em XII Biochemistry Day, 2021.
  36. Ana Dias Carvalho; Ana Reis-Mendes; Margarida Duarte-Araújo; Maria de Lourdes Bastos; Carvalho, Félix; Sá, Susana I; Sá SI; Capela, João Paulo; Costa, Vera Marisa. "Chemobrain: evaluation of doxorubicin and mitoxantrone neurotoxicity in cd-1 mice". Trabalho apresentado em SPF Meeting 2021 - Sociedade Portuguesa de Farmacologia, 2021.
  37. Dias-Carvalho, Ana; Ferreira, Mariana; Fernandes, Ana; Reis-Mendes, Ana; Araújo, Ana Margarida; Ferreira, Rita; Carvalho, Félix; et al. Autor correspondente: Dias-Carvalho, Ana. "The long-term neurotoxicity of doxorubicin in the brain of adult CD-1 mice". Trabalho apresentado em Congress of the European Societies of Toxicology (EUROTOX Congress 2021), 2021.
  38. Carvalho, Ana Rita; Reis-Mendes, Ana; Duarte-Araujo, Margarida; Carvalho, Félix; Bastos, Maria de Lourdes; Sá, Susana I; Capela, João Paulo; et al. "Chemobrain study: differential effects of doxorubicin and mitoxantrone in the brain of CD-1 mice". Trabalho apresentado em 1st International Electronic Conference on Brain Science, 2020.
  39. Sá, Susana I; Sá SI; Ana Dias Carvalho; Ana Reis-Mendes; Margarida Duarte-Araújo; Carvalho, Félix; Maria de Lourdes Bastos; Capela, João Paulo; Costa, Vera Marisa. "Evaluation of doxorubicin and mitoxantrone neurotoxicity in cd-1 mice". Trabalho apresentado em SIFFUP - Simpósio de Investigação da FFUP, 2020.
  40. Araújo, Ana Margarida; Márcia Cláudia Dias de Carvalho; Costa, Vera Marisa; Duarte, José Alberto; Dinis-Oliveira, Ricardo Jorge; Bastos, Maria de Lourdes; de Pinho, Paula Guedes; Carvalho, Félix. "Application of in vivo metabolomics to evaluate the early pathways of toxicity triggered by human-relevant doses of 3,4-methylenedioxypyrovalerone (MDPV)". Trabalho apresentado em 16th Annual Conference of Metabolomics Society - Metabolomics Online 2020, 2020.
  41. Carvalho, Ana Rita; Reis-Mendes, Ana; Duarte-Araujo, Margarida; Carvalho, Félix; Bastos, Maria de Lourdes; Capela, João Paulo; Sá, Susana I; et al. "Neurotoxicidade da mitoxantrona e doxorrubicina: estudo in vivo em diferentes idades". Trabalho apresentado em 2º Encontro Nacional de Jovens Investigadores em Oncologia, 2020.
  42. Dias-Carvalho, Ana; Fernandes, Ana Olivía ; Reis-Mendes, Ana; Duarte-Araújo, Margarida; Carvalho, Félix; Capela, João Paulo; Sá, Susana Isabel; Costa, Vera Marisa. "Doxorubicin Increases Apoptotic Markers in the hipocampal formation of CD-1 mice". Trabalho apresentado em VI jornadas da Bioquímica: ¿O passaporte para a inovação¿, 2020.
  43. Sánchez-Momblona, Marina; Dionísio, Flávio; Reis-Mendes, Ana Filipa ; Duarte-Araujo, Margarida; Carvalho, Félix; Bastos, Maria De Lourdes; Costa, Vera M. "The effects of doxorubicin and mitoxantrone in the spleen of mice at different ageing stages". Trabalho apresentado em 13rd Meeting of young researchers of University Porto, 2020.
  44. Ana Dias Carvalho; Ana Reis-Mendes; Margarida Duarte-Araújo; Carvalho, Félix; Sá, Susana I; Sá SI; Capela, João Paulo; Costa, Vera Marisa. "The effects of doxorubicin and mitoxantrone in mice brain at different aging stages: an in vivo chemobrain study". Trabalho apresentado em SPF 2020 ¿ Reunião Anual da Sociedade Portuguesa de Farmacologia, 2020.
  45. Ana Dias Carvalho; Ana Reis Mendes; Margarida Duarte-Araújo; Carvalho, Félix; Sá, Susana I; Sá SI; Capela, João Paulo; Costa, Vera Marisa. "The effects of doxorubicin and mitoxantrone in the brain of different age mice: in vivo chemobrain study". Trabalho apresentado em 13th Meeting of Young researchers of University of Porto (IJUP), 2020.
  46. Rodrigues, Daniela; Costa, Vera M; Bastos, Maria De Lourdes; Carvalho, Félix. "Effects of alpha-amanitin in HepG2 cells are not prevented by drugs used in Amanita phalloides intoxications". Trabalho apresentado em EUROTOX 2019 - 55th Annual Meeting of the Society of the European Toxicology Society, 2019.
  47. Dionísio, Flávio; Duarte-Araujo, Margarida; Bastos, Maria De Lourdes; Carvalho, Félix; Costa, Vera M. "Cyclophosphamide metabolites 4-hydroxycyclophosphamide and acrolein exert strenuous cardiotoxicity in AC16 human cardiomyocytes, at clinical relevant concentrations". Trabalho apresentado em EUROTOX 2019 - 55th Annual Meeting of the Society of the European Toxicology Society, 2019.
  48. Carvalho, Ana Rita; Reis-Mendes, Ana Filipa; Duarte-Araujo, Margarida; Guedes, Rita; Gonçalves-Monteiro, Salomé; Carvalho, Félix; Bastos, Maria de Lourdes; Capela, João Paulo; Costa, Vera M. "Doxorubicin and mitoxantrone effects on the brain of differently aged mice: an in vivo chemobrain study". Trabalho apresentado em 55th Annual Meeting of the Society of the European Toxicology Society - EUROTOX 2019, 2019.
  49. Aires, A; Costa, Vera M; Brandão, Sofia; Ferreira, Rita. "Disclosing the molecular mechanisms underlying sarcopenia". Trabalho apresentado em XI Biochemistry Day - The challenges and the opportunities of Biochemistry, University of Aveiro, Aveiro, Portugal, 2019.
  50. Reis-Mendes, Ana Filipa; Duarte-Araujo, M.; Duarte, José Alberto; Gonçalves-Monteiro, Salomé; Carvalho, Félix; Bastos, Maria de Lourdes; Sousa, Emilia; Costa, Vera M. "Mitoxantrone-induced toxicity in different age male CD-1 mice.". Trabalho apresentado em 53rd Annual Scientific Meeting of the European Society for Clinical Investigation "The Clocks of Metabolism and Disease", Coimbra, Portuga, 2019.
  51. Reis-Mendes, Ana Filipa; Duarte-Araújo, Margarida; Duarte, José Alberto; Gonçalves-Monteiro, Salomé; Carvalho, Félix; Bastos, Maria de Lourdes; Sousa, Emília; Costa, Vera M. "Evaluation of the toxicity induced by doxorubicin in different age male CD-1 mice". Trabalho apresentado em 53rd Annual Scientific Meeting of the European Society for Clinical Investigation "The Clocks of Metabolism and Disease", Coimbra, Portugal, 2019.
  52. Rodrigues, Daniela; Costa, Vera M; Bastos, Maria de Lourdes; Carvalho, Félix. "N-Acetylcysteine, silibinin and benzylpenicillin do not confer protection against a-amanitin cytotoxicity in HepG2 and HepaRG cells". Trabalho apresentado em 58th Annual Meeting of the Society of Toxicology, Baltimore, Maryland, EUA, 2019.
  53. Costa, Vera M; Capela, João Paulo; Silveira, CM; Rodrigues, Patrícia; Eleutério, Rute; Dores-Sousa, José Luís; Carvalho, Rui A; et al. "Mitoxantrone prompts early energetic and proteomic changes in HL-1 cardiomyocytes and late oxidative stress in clinically relevant doses.". Trabalho apresentado em 58th Annual Meeting of the Society of Toxicology, Baltimore, Maryland, EUA, 2019.
  54. Dias-Carvalho, Ana; Reis-Mendes, Ana; Duarte-Araújo, Margarida; Guedes, Rita; Gonçalves-Monteiro, Salomé; Carvalho, Félix; Bastos, Maria Lourdes; Capela, João Paulo; Costa, Vera Marisa. "Differential effects of doxorubicin and mitoxantrone in the brain redox status of differently aged mice". Trabalho apresentado em 10th Annual International (bio)Medical Students Meeting, 2019.
  55. Carvalho, Ana Rita; Reis-Mendes, Ana Filipa; Duarte-Araújo, Margarida; Guedes, Rita; Gonçalves-Monteiro, Salomé; Carvalho, Félix; Bastos, Maria de Lourdes; Capela, João Paulo; Costa, Vera M. "The effects of doxorubicin and mitoxantrone in brain glutathione levels of differently aged mice". Trabalho apresentado em Translational Research at iMed Conference® 10.0 | Lisboa 2018, Lisboa, Portugal, 2018.
  56. Soares, Jorge; Costa, Vera M; Bronze, Susana; Gaspar, Helena; Santos, Susana; Bastos, Maria De Lourdes; Carvalho, Félix; Capela, João Paulo. "Neurotoxicity of synthetic cathinones and evaluation of putative neuroprotectors". Trabalho apresentado em Innovations in Pharmacy. Advances & perspectives (IPAP18), Salamanca, Spain, 2018.
  57. Soares, Jorge; Costa, Vera M; Bronze, Susana; Gaspar, Helena; Santos, Susana; Bastos, Maria de Lourdes; Carvalho, Félix; Capela, João Paulo. "Clorgyline and N-acetyl-L-cysteine provide partial protection against the toxicity of synthetic cathinones and methamphetamine on SH-SY5Y humans cells". Trabalho apresentado em 54th Congress of European Societies of Toxicology, (Eurotox 2018) Brussels, Belgium, 2018.
  58. Reis-Mendes, Ana; Carvalho, Félix; Sousa, Emília; Bastos, Maria de Lourdes; Costa, Vera M. "Cardiotoxicity of FAC (5-Fluorouracil + Adriamycin + Cyclophosphamide) Metabolites in H9c2 Cardiac Differentiated Cells". Trabalho apresentado em 54th Congress of European Societies of Toxicology, (Eurotox 2018) Brussels, Belgium, 2018.
  59. Guedes, Rita; Cravo, Sara; Reis-Mendes, Ana; Duarte-Araújo, Margarida; Bastos, Maria de Lourdes; Sousa, Emília; Costa, Vera M. "The influence of metabolism on MTX-induced toxicity: a pharmacokinetic study using adult and infant male CD-1 mice". Trabalho apresentado em Italian-Spanish-Portuguese Joint Meeting in Medicinal Chemistry (MedChemSicily2018), Palermo, Italy, 2018.
  60. Reis-Mendes, Ana; Carvalho, Félix; Sousa, Emília; Bastos, Maria de Lourdes; Costa, Vera M. "Main metabolites of 5-fluorouracil + adriamycin + cyclophosphamide (FAC) are not major contributors to FAC toxicity in H9c2 cardiac differentiated cells". Trabalho apresentado em International Symposium - MitoPorto - mitochondrial evolution, metabolism and disease, Porto, Portugal, 2018.
  61. Brandão, Sofia; Ferreira, Rita; Vitorino, Rui; Costa, Vera M. "Exploring the cardiotoxic effect of anticancer drugs using a network-based approach". Trabalho apresentado em Novel Therapeutic Strategies for Noncommunicable Diseases (NoTeS), Faculdade de Medicina – Universidade do Porto, Porto, Portugal, 2018.
  62. Guedes, Rita; Reis-Mendes, Ana; Gonçalves-Monteiro, Salomé; Capas, Sara; Duarte-Araújo, Margarida; Bastos, Maria de Lourdes; Sousa, Emília; Costa, Vera M. "The influence of age on mitoxantrone-induced toxicity: an in vivo study using adult and infant CD-1 male mice". Trabalho apresentado em XI Encontro Nacional de Estudantes de Bioquímica, Porto, Portugal, 2018.
  63. Costa, Vera M; Capela, João Paulo; Silveira, Célia M; Eleutério, Rute P; Rodrigues, Patrícia RS; Bastos, Maria de Lourdes; Alberto, José Alberto; et al. "Mitoxantrone elicits oxidative stress and proteomic changes in HL-1 cardiomyocytes at clinically relevant doses". Trabalho apresentado em Escola de Inverno de Farmácia - 3ª Edição (EIF2018), Porto, Portugal, 2018.
  64. Alves, Marisa; Reis-Mendes, Ana; Carvalho, Félix; Remião, Fernando; Bastos, Maria Bastos; Costa, Vera M. "An in vitro study with differentiated and non-differentiated H9c2 cells to evaluate pixantrone cardiotoxicity". Trabalho apresentado em 11st Meeting of young researchers of University Porto (IJUP ’18), Porto, Portugal, 2018.
  65. Guedes, Rita; Reis-Mendes, Ana; Gonçalves-Monteiro, Salomé; Capas, Sara; Duarte-Araújo, Margarida; Bastos, Maria de Lourdes; Sousa, Emília; Costa, Vera M. "Mitoxantrone-induced toxicity in adult and infant male CD-1 mice". Trabalho apresentado em 11st Meeting of young researchers of University Porto (IJUP ’18), Porto, Portugal, 2018.
  66. Loureiro, Sara; Costa, Vera M; Duarte, José Alberto; Duarte-Araújo, Margarida; Gonçalves-Monteiro, Salomé; Bastos, Maria de Lourdes; Carvalho, Félix; Capela, João Paulo. "Methylphenidate evokes heart and kidney toxicity in adolescent rats exposed one-week to relevant oral doses". Trabalho apresentado em Lisbon Addictions 2017, Lisboa, Portugal, 2017.
  67. Hrynchak, Ivanna; Sousa, Emília; Bastos, Maria de Lourdes; Pinto, Madalena; Costa, Vera M. "Studies towards the synthesis of dicarboxylic acid metabolite of mitoxantrone". Trabalho apresentado em 12nd International YES Meeting, Porto, Portugal, 2017.
  68. Pinho, Rita; Almeida, Daniela; Soares, Jorge; Bastos, Maria de Lourdes; Carvalho, Félix; Capela, João Paulo; Costa, Vera M. "Mitoxantrone was more neurotoxic than doxorubicin in SH-5YSY human cells". Trabalho apresentado em 10th Meeting of young researchers of University Porto (IJUP ’17), Porto, Portugal, 2017.
  69. Hrynchak, Ivanna; Sousa, Emília; Pinto, Madalena; Bastos, Maria de Lourdes; Costa, Vera M; Hrynchak, Ivanna; Bastos, M.L; Costa, Vera Marisa. "Synthesis and characterization of the main metabolites of mitoxantrone". Trabalho apresentado em 10th Meeting of young researchers of University Porto (IJUP ’17), Porto, Portugal, 2017.
  70. Hrynchak, Ivanna; Sousa, Emília; Bastos, Maria de Lourdes; Pinto, Madalena; Costa, Vera M. "The main metabolites of mitoxantrone: synthesis and structure elucidation". Trabalho apresentado em Escola de Inverno de Farmácia - 2ª Edição (EIF2017), Porto, Portugal, 2017.
  71. Boieng, Joana; Ribeiro, Daniela; Costa, Vera M; Visentainer, JV; Freitas, Marisa; Fernandes, Eduarda. "Bactris setosa, an underexploited brazilian fruit, shows protective effects against oxidative cellular damage". Trabalho apresentado em Sociedade Portuguesa de Química - Divisão de Química Alimentar, Porto, Portugal, 2016.
  72. Soares, Jorge; Costa, Vera M; Bronze, Susana; Gaspar, Helena; Santos, Susana; Carvalho, Félix; Bastos, Maria de Lourdes; Capela, João Paulo. "Neurotoxicity of synthetic cathinones on differentiated SH-SY5Y human dopaminergic cells". Trabalho apresentado em 52nd Congress of European Societies of Toxicology, (Eurotox 2016) Seville, Spain, 2016.
  73. Reis-Mendes, Ana; Gomes, Ana Sara; Carvalho, R.A.; Remião, Fernando; Carvalho, Félix; Pinto, Madalena; Bastos, Maria de Lourdes; Sousa, Emília; Costa, Vera. "Unveiling the cardiotoxicity of anticancer drugs: A comparative in vitro study between mitoxantrone and its naphthoquinoxaline metabolite". Trabalho apresentado em 51st Congress of the European Societies of Toxicology (Eurotox 2015), 2015.
  74. Reis-Mendes, Ana; Gomes, Ana Sara; Carvalho, R.A.; Remião, Fernando; Carvalho, Félix; Pinto, Madalena; Bastos, Maria de Lourdes; Sousa, Emília; Costa, Vera. "The cardiotoxicity of mitoxantrone: A comparative in vitro study between mitoxantrone and its naphthoquinoxaline metabolite". Trabalho apresentado em IJUP¿15 ¿ 8th Meeting of Your Researchers of the University of Porto, 2015.
  75. Dores-Sousa, José Luís; Duarte, José Alberto; Seabra, Vítor; Bastos, Maria Lourdes; Carvalho, Félix Dias; Costa, Vera M. "Mitoxantrone's multiple cardiac targets: the age factor for toxicity". Trabalho apresentado em 50th Congress of European Societies of Toxicology, (Eurotox 2014), 2014.
  76. Rodrigues, Patrícia; Eleutério, Rute; Silveira, Célia; Costa, Vera M; Almeida, Maria Gabriela. "Why is Mitoxantrone a poison to the heart?". Trabalho apresentado em VII Encontro Nacional de Estudantes de Bioquímica, (ENEBIOQ 2014) Faculty of Nova of Sciences and Technology, 2014.
  77. Silva, Renata; Costa, Vera M; Vitorino, Rui; Amado, Francisco; Carvalho, Félix Dias; Bastos, Maria De Lourdes; Carvalho, Rui Albuquerque; Remião, Fernando. "Effect of adrenaline oxidation process in the protein content of freshly isolated cardiomyocytes". Trabalho apresentado em 4th Annual Meeting of the Portuguese Network (Procura) 1st Meeting of the Portuguese National Mass Proteomics Spectrometry Network (RNEM) (Meeting ProCura RNEM 2007), 2007.
Resumo em conferência
  1. Brandão, Sofia; Reis-Mendes, Ana; Duarte-Araújo, Margarida; Neuparth, Maria João; Bastos, Maria de Lourdes; Carvalho, Félix; Ferreira, Rita; Costa, Vera Marisa. "The influence of the anticancer drugs doxorubicin and mitoxantrone on cardiac metabolism and autophagy". Trabalho apresentado em 56th Congress of the European Societies of Toxicology (EUROTOX 2021), 2021.
    https://doi.org/10.1016/S0378-4274(21)00556-7
  2. Sofia R, Brandão; Reis-Mendes, Ana; Carvalho, Félix; Bastos, Maria de Lourdes; Ferreira, Rita; Costa, Vera Marisa. "Effects of doxorubicin and mitoxantrone on mice cardiac mitochondrial proteome". Trabalho apresentado em 50th Meeting of the Portuguese Society of Pharmacology, 38th Meeting of Clinical Pharmacology and 19th Meeting of Toxicology (SPF 2020), Coimbra, 2020.
    Publicado
  3. Dionísio, Flávio; Araújo, Ana Margarida; Duarte-Araújo, Margarida; Guedes de Pinho, Paula; Bastos, Maria de Lourdes; Carvalho, Félix; Costa, Vera Marisa. "Cyclophosphamide main bioactivation products cause disturbance in the metabolome of AC16 cardiac cells at clinically relevant concentrations". Trabalho apresentado em 5th International Electronic Conference on Medicinal Chemistry, 2019.
    Publicado
  4. Feio-Azevedo, R.; Costa, Vera Marisa; Gomes, Ana; Pita, Inês; Sequeira, A; Pereira, Frederico; Duarte-Araújo, M.; et al. "Aged rats are more prone to ecstasy neurotoxicity than adolescent rats". Trabalho apresentado em 50th Congress of the European Societies of Toxicology (EUROTOX), Edimburgo, 2014.
    Publicado
  5. Remiao, Fernando; Rossato, Luciana Grazziotin; Dallegrave, Eliane; Arbo, Marcelo; Silva, Renata; Ferreira, Rita; Amado, Francisco; et al. "Mitochondrial impairment after mitoxantrone multi-administration to male Wistar rats". 2013.
    10.1016/j.toxlet.2013.05.373
  6. Grazziotin Rossato, L.; Marisa Costa, V.; Guedes De Pinho, P.; Silva, R.; Carvalho, F.; Carmo, H.; Bastos, M.D.L.; et al. "Development of a GC/IP-MS method for simultaneous quantification of para and meta-synephrine in Caco-2 cells". Trabalho apresentado em 2010 IUTOX International Congress of Toxicology, Barcelona, 2010.
    10.1016/j.toxlet.2010.03.926
Tese / Dissertação
  1. Costa, Vera Marisa Freitas. "Role of catecholamines and reactive oxygen species in the mechanism of oxidative stress-induced heart disease:in vitro studies using fresly isolated rat cardiomyocytes". Doutoramento, 2011. http://hdl.handle.net/10216/20812.
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2023/05/03 Exploring Proline's Puckering Effect on the Allosteric Modulatory Activity of Melanostatin Neuropeptide Simpósio de Investigação da Faculdade de Farmácia da Universidade do Porto 2023
Faculdade de Farmácia da Universidade do Porto (Porto, Portugal)
2023/04/28 The influence of glutathione pathway modulators on the cytotoxicity of sunitinib, doxorubicin and bortezomib in AC16 cardiac cells. This oral communication was selected for the Scientific Committee of the event. II TOXRUN International Congress;
TOXRUN – Toxicology Research Unit, CESPU (Porto, Portugal)
2023/04/27 Cardiac mitochondrial dynamics, autophagy and regeneration are stirred by doxorubicin in old CD-1 mice. This oral communication was selected for the Scientific Committee of the event. II TOXRUN International Congress
TOXRUN – Toxicology Research Unit, CESPU (Porto, Portugal)
2023/02 Cardiac metabolism, proteolysis and regeneration are disturbed by mitoxantrone in old CD-1 mice. 53rd Meeting of the Portuguese Society of Pharmacology, 41st Meeting of Clinical Pharmacology and 22nd Meeting of Toxicology (SPF 2023)
Faculty of Medicine of University of Coimbra (Coimbra, Portugal)
2022/12/07 Cardio-oncology: for old or new drugs, the problem (cardiotoxicity) remains after cancer treatment Cardio-oncology: from adverse outcome pathways to treatments to mitigate cardiotoxicity of anticancer therapies’
MDPI (Suiça)
2022/11 In the heart of cardio-oncology: the targets and biomarkers of anticancer drugs cardiotoxicity 8th International Electronic Conference on Medicinal Chemistry
MDPI (Online, Suiça)
2022/09/08 Cardio-oncology: something old, something new, something bowered and something blue ystems in Toxicology and Pharmacology – Current challenges
(Online)
2022/09/04 The dark side of anticancer therapy: in the heart of cardio-oncology SPF Seminars
Sociedade Portuguesa de Farmacologia (Online, Portugal)
2022/04 Molecular alterations underlying doxorubicin’s chronic cardiotoxicity in a mouse model. This oral communication was selected for the Scientific Committee of the event I International Congress of TOXRUN, V Congress of Portuguese Association of Forensic Sciences, XIV Scientific Journeys of Sciences of University Institute of Health Sciences
TOXRUN – Toxicology Research Unit, CESPU (Porto, Portugal)
2020/11 Evaluation of doxorubicin and mitoxantrone neurotoxicity in CD-1 mice 2ª Edição do Simpósio de Investigação da Faculdade de Farmácia da Universidade do Porto (FFUP)
Faculdade de Farmácia da Universidade do Porto (FFUP) (Porto, Portugal)
2019/11/27 The heart of the matter: cardiotoxicity mechanisms in new and old anticancer drugs no 8º ciclo de palestras públicas de divulgação científica por professores na Faculdade de Farmácia da Universidade do Porto e Instituto de Biomédicas Abel Salazar (ICBAS)
Faculdade de Farmácia da Universidade do Porto e Instituto de Biomédicas Abel Salazar (ICBAS) (Porto, Portugal)
2017/11/01 Old Pharmaceuticals with New Applications: the Case Studies of Lucanthone and Mitoxantrone 3rd International Electronic Conference on Medicinal Chemistry
MDPI
2016/11 Combater o cancro e envenenar o coração: a dura realidade da terapia anticancerígena 5º Ciclo de palestras públicas de divulgação científica por professores
Faculdade de Farmácia da Universidade do Porto e Instituto de Biomédicas Abel Salazar (Porto, Portugal)
2016/07/10 É o metabolismo dos fármacos anticancerígenos um factor crucial para o desenvolvimento de cardiotoxicidade? Serão os anticancerígenos causadores de envelhecimento cardíaco? 1º Encontro Anual do Departamento de Ciências Biológicas
Faculdade de Farmácia da Universidade do Porto (Porto, Portugal)
2014/11 Drogas no local de trabalho IX Congresso da Associação de Estudantes / Toxicomanías e drogas de abuso
Faculdade de Farmácia da Universidade do Porto (Porto, Portugal)
2012/11 Estudo de caso: Mitoxantrona - reações adversas VII Congresso da Associação de Estudantes/ Reações adversas e interações medicamentosas: O outro lado Farmacoterapia’
Faculdade de Farmácia da Universidade do Porto (Porto, Portugal)
2012/09 In vitro models of cardiotoxicity European “Advanced Course in Toxicology”
European Toxicologist Association - Eurotox and Sociedade Portuguesa de Farmacologia (Porto, Portugal)
2012/07 Ecstasy' and amphetamine neurotoxicity to cultured rat cortical neurons in a continuous exposure model 6th European Congress on Pharmacology EPHAR 2012
European Society of Pharmacologists (Granada, Espanha)
2012/02 Riscos da exposição a resíduos Resíduos em Portugal
Escola Superior Agrária de Coimbra (Coimbra, Portugal)
2011/08 Therapeutic concentrations of mitoxantrone elicit cytotoxic effects on H9c2 cells 47th Congress of the European Societies of Toxicology
(Paris, França)
2011/05 Understanding the role of NRF2/ARE signalling in the cellular defence against iron toxicity International BioIron Society Biennial World Meeting (IBIS 2011 - Vancouver)
BioIron Society Biennial World Society (Vancouver, Canadá)
2011/04 Avaliação in vitro da potencial cardiotoxicidade dos compostos. Exemplos de estudos em cardiomiócitos isolados Avaliação in vitro da segurança dos compostos
Faculdade de Farmácia da Universidade do Porto (Porto, Portugal)
2009/09 Adrenaline and reactive oxygen species elicit proteome and energetic metabolism modifications in freshly isolated rat cardiomyocytes 46th Congress of European Societies of Toxicology
(Dresden, Alemanha)
2009/05 Biomarcadores tumorais Workshop Neoplasia
Instituto Superior de Ciências da Saúde do Norte (Paredes, Portugal)
2007/12 Time dependent activation of transcription factors in freshly isolated rat cardiomyocytes under stimulation by adrenaline and reactive oxygen species. XXXVIII Reunião Anual da Sociedade Portuguesa de Farmacologia, XXV Reunião de Farmacologia Clínica
Sociedade Portuguesa de Farmacologia (Coimbra, Portugal)
2007/12 Mediated membrane transport in isolated cardiac myocytes via catecholamine uptake 2 and 5-(glutathion-S-yl)adrenaline efllux by MRP1 XXXVIII Reunião Anual da Sociedade Portuguesa de Farmacologia, XXV Reunião de Farmacologia Clínica
Sociedade Portuguesa de Farmacologia (Coimbra, Portugal)
2007/12 Oxidation of adrenaline in cardiomyocytes: formation of adrenochrome, quinoproteins, and GSH-adducts XXXVII Reunião Anual da Sociedade Portuguesa de Farmacologia, XXIV Reunião de Farmacologia Clínica
Sociedade Portuguesa de Farmacologia (Porto, Portugal)

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2024/01/01 - Atual Synthesis and Biological Evaluation of Alicyclic Melanostatin and Glypromate Peptidomimetics with Application in Neurodegenerative Diseases
Coorientador
 PhD Sustentable Chemistry (Doutoramento)
Universidade do Porto Faculdade de Ciências, Portugal
2023/01/01 - Atual Amphetamine (AMPH) and D,L-threo-Methylphenidate (MPH) ability to synaptogenesis in an attention-deficit/hyperactivity disorder (ADHD) rat model
Coorientador
 Toxicologia Analítica Clínica e Forense (Mestrado)
Universidade do Porto Faculdade de Farmácia, Portugal
2023/01 - Atual A toxicological in vitro comparative study of alpha-PVP, 3,4-dimethylmethcatinone (3,4-DMMC) and mephedrone (4-MMC) in human cardiac AC16 cells
Orientador
 Toxicologia Analítica Clínica e Forense (Mestrado)
Faculty of Pharmacy of University of Porto, Portugal
2023/01 - Atual The study of the cardiotoxicity of anthracyclines anticancer drugs: a comparative metabolomics study
Orientador
 Toxicologia Analítica Clínica e Forense (Mestrado)
Faculty of Pharmacy of University of Porto, Portugal
2023/01 - Atual The neurotoxic mechanisms of new and old anticancer drugs on astrocytes: an in vitro study in C6 cells
Orientador
 Toxicologia Analítica Clínica e Forense (Mestrado)
Faculty of Pharmacy University of Porto, Portugal
2021/11/01 - Atual The neurotoxic mechanisms of new and old anticancer drugs: from in vitro to in vivo studies
Orientador
 Doutoramento em Ciências Farmacêuticas (Doutoramento)
Faculty of Pharmacy of University of Porto, Portugal
2021/03/01 - Atual Unveiling the neurotoxic mechanisms of anticancer drugs: combining insights from neuronal and glial contributions to chemobrain
Orientador
 Pharmaceuticals Sciences (Doutoramento)
REQUIMTE, Portugal

Faculty of Pharmacy University of Porto, Portugal
2020/01/01 - Atual NeuroPro: Peptide Conjugates for Neurodegenerative Diseases using Constrained Prolines
Coorientador
 Química Sustentável (Doutoramento)
Universidade do Porto Faculdade de Ciências, Portugal
2019/07/01 - Atual Can early biomarkers of aging predict the cardiotoxicity induced by doxorubicin and mitoxantrone? An Omics approach on early biomarkers of aging
Orientador
 PhD in Pharmaceutical Sciences (Doutoramento)
Universidade do Porto Faculdade de Farmácia, Portugal
2018/02/01 - 2024/04/11 Inflammation and disruption of redox homeostasis (but not metabolism) significantly contribute to the cardiotoxic effects of mitoxantrone and doxorubicin: findings from in vitro and in vivo studies conducted on differently aged mice
Orientador
 PhD in Pharmaceutical Sciences (Doutoramento)
Universidade do Porto Faculdade de Farmácia, Portugal
2022/09/01 - 2023/11/22 Synthesis and Biological Evaluation of Melanostatin Aza-Peptides for Application in Parkinson's Disease
Coorientador
 Bioquímica (Mestrado)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2022/09/01 - 2023/11/22 Synthesis, Pharmacological, and Toxicological Evaluation of Carbamate-Based Melanostatin Analogues with Potential Anti-Parkinson Activity
Coorientador
 Química Farmacêutica (Mestrado)
Universidade do Porto Faculdade de Farmácia, Portugal
2022/09/01 - 2023/11/16 Nrf2 modulators as pharmacological strategies to tackle the cardiotoxicity of anti-cancer drugs: a cardio-oncology in vitro study in human cardiac AC16 cells
Orientador
 Bioquímica (Mestrado)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2020/09/01 - 2022/12/06 The study of the cardiotoxicity of targeted anticancer drugs: an in vitro metabolomics study
Orientador
 Toxicologia Analítica Clínica e Forense (Mestrado)
Faculty of Pharmacy of University of Porto, Portugal
2019/09/01 - 2022/12/06 Neuroprotection of Amphetamine and Methylphenidate psychostimulants against dopaminergic neurotoxins in an in vitro Parkinson model
Coorientador
 Mestrado em Toxicologia Analítica Clínica e Forense (Mestrado)
Faculty of Pharmacy University of Porto, Portugal
2020/09/01 - 2021/10/14 Chemobrain: the neurotoxic mechanisms of doxorubicin and mitoxantrone
Orientador
 Master in Biochemistry (Mestrado)
Universidade de Aveiro Departamento de Química, Portugal
2015/02/01 - 2021/06/21 Neurotoxicity of synthethic cathinones
Coorientador
 Ph in Experimental and Clinical Pharmacology and Toxicology (Doutoramento)
Universidade do Porto Faculdade de Medicina, Portugal
2019/09/01 - 2020/12/11 Biomarkers of heart damage caused by cyclophosphamide: a proteomic and metabolomic approach in AC16 human cardiomyocyte cells and CD-1 mice
Orientador
 Master of Biochemistry (Mestrado)
Faculty of Sciences University of Porto, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2018/09/30 - 2020/12/09 The neurotoxicity of doxorubicin and mitoxantrone in different aged mice: in vivo studies of chemobrain
Orientador
 MSc in Analytical, Clinical and Forensic Toxicology (Mestrado)
Faculty of Pharmacy University of Porto, Portugal
2017 - 2019 In vitro evaluation of antidotes for Amanita Phalloides intoxications
Coorientador
 Controlo de Qualidade (Mestrado)
Universidade do Porto Faculdade de Farmácia, Portugal
2018 - 2018 The influence of age on the toxicity induced by mitoxantrone: in vivo studies with mice
Orientador
 Toxicologia Analítica Clínica e Forense (Mestrado)
Universidade do Porto Faculdade de Farmácia, Portugal
2017 - 2018 Studies towards the synthesis of metabolites of mitoxantrone
Coorientador
 Química Farmacêutica (Mestrado)
Universidade do Porto Faculdade de Farmácia, Portugal
2016 - 2017 Methylphenidate effects after one-week exposure in adolescente rats
Coorientador
 Toxicologia Analítica Clínica e Forense (Mestrado)
Universidade do Porto Faculdade de Farmácia, Portugal
2015/09/01 - 2016/12/06 Comparação da citotoxicidade de fármacos anticancerígenos e da sua mistura em células H9c2 diferenciadas
Orientador
 Master in Toxicology and Ecotoxicology
Universidade de Aveiro Departamento de Biologia, Portugal
2014 - 2015 Brain and Peripheral Organ Toxicity of "Ecstasy" in Adolescent Rats in Human Relevant Doses
Coorientador
 Toxicologia Analítica Clínica e Forense (Mestrado)
Universidade do Porto Faculdade de Farmácia, Portugal
2011 - 2015 Discovery of an effective antidote for Amanita Phalloides poisoning
Coorientador
 Ciências Farmacêuticas (Doutoramento)
Universidade do Porto Faculdade de Farmácia, Portugal
2013/09/05 - 2014/11/14 The Synthesis and in Vitro Toxicological Evaluation of the Mitoxantrone Naphthoquinoxaline Metabolite: A Comparative Study with the Parent Drug
Orientador
 Master in Clinic, Forensic and Analytic Toxicology (Mestrado)
Universidade do Porto Faculdade de Farmácia, Portugal
2010 - 2014/01 The cardiotoxicity of mitoxantrone: a mechanistic approach using in vitro and in vivo models.
Coorientador
 Ciências Farmacêuticas (Doutoramento)
Universidade do Porto Faculdade de Farmácia, Portugal
2013 - 2013 Toxicity of the antitumor drug mitoxantrone in pediatric and adult mice
Orientador
 Bioquímica (Mestrado)
Universidade do Porto Faculdade de Ciências, Portugal
2009 - 2010/07/10 Estudo do transporte celular da sinefrina e da sua interacção com a glutationa em suspensões de cardiomiócitos isolados de rato adulto
Coorientador
 Master in Analytical, Forensic and Clinical Toxicology (Mestrado)
Faculty of Pharmacy of University of Porto, Portugal

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação) 		Instituição / Organização
2022/12/07 - Atual Cardio-oncology: from adverse outcome pathways to cardiotoxicity mitigation, online event (https://pharmaceuticals-1.sciforum.net/) (2022/12/07)
Simpósio (Coorganizador)
 MDPI AG, Suiça
2023/07/05 - 2023/07/07 Joint Session of i4HB and CIMAR - Encontro Ciência 2023, Aveiro (2023/07/07 - 2023/07/07)
Conferência (Membro da Comissão Organizadora)
 Fundação para a Ciência e a Tecnologia, Portugal
2023/01/16 - 2023/01/23 Continuous Training Unit (UFC) within the scope of the Multidisciplinary Training Program of the U. Porto - Impulse Adults, funded by the Recovery and Resilience Plan (PRR) (2023/01/16 - 2023/01/23)
Oficina (workshop) (Coorganizador)
 Faculty of Medicine of University of Porto, Portugal
2019/03/06 - 2019/03/06 Workshop on animal models of disease (2019/03/06 - 2019/03/06)
Oficina (workshop) (Membro da Comissão Científica)
 Universidade de Aveiro Centro de Espectrometria de Massa, Portugal
2019/02/06 - 2019/02/08 XLIX Meeting of the Portuguese Pharmacology Society, XXXVII Meeting of Clinical Pharmacology, XVIII Meeting of Toxicology (2019/02/06 - 2019/02/08)
Encontro (Membro da Comissão Organizadora)
 Universidade do Porto Faculdade de Farmácia, Portugal
2018/07/10 - 2018/07/10 Manhã do Departamento de Ciências Biológicas was a interlaboratory meeting to discusse new findings and establish (2018/07/10 - 2018/07/10)
Seminário (Membro da Comissão Organizadora)
 Universidade do Porto Faculdade de Farmácia, Portugal
2017/10/23 - 2017/10/27 TOX-OER (Learning Toxicology through Open Educational Resources) is a project, which aims to design and develop an international Massive Open Online Course (MOOC) on Toxicology. Intensive Learners Meeting Pharmaco/Toxicokinetics was held in modules in Toxicology Laboratory in Faculty of Pharmacy (2017/10/23 - 2017/10/27)
Oficina (workshop) (Membro da Comissão Organizadora)
 Universidade do Porto Faculdade de Farmácia, Portugal
2015/09/13 - 2015/09/16 Organization of the International congress: 51st European Congress of Toxicology Societies (2015/09/13 - 2015/09/16)
Congresso (Outra)
 Federation of European Toxicologists & European Societies of Toxicology, Suiça

Júri de grau académico

Tema
Tipo de participação 		Nome do candidato (Tipo de grau)
Instituição / Organização
2023/11/28 Influence of antiparasitic benzimidazole derivatives in the cytoskeletal organization of metastatic breast cancer cells
Arguente principal
 Patrícia Isabel Pinto Nogueira (Mestrado)
Faculty of Pharmacy University of Porto, Portugal
2023/10/09 Investigating the dynamics of proliferative cardiomyocytes: validation of an in vitro model
Arguente
 Rodrigo Vieira Teixeira de Sousa Santos (Mestrado)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Universidade do Porto Faculdade de Engenharia, Portugal
2023/09/26 Flavonoides como moduladores da diabetes tipo 2 através da inibição das enzimas a-amilase e alpha-glucosidase
Arguente principal
 Edite Ferreira Pinto (Mestrado)
Universidade do Porto Faculdade de Ciências, Portugal
2022/12/06 The study of the cardiotoxicity of targeted anticancer drugs: an in vitro metabolomics study
Orientador
 Tânia Gomes (Mestrado)
Faculty of Pharmacy of University of Porto, Portugal
2021/10/14 Chemobrain: the neurotoxic mechanisms of doxorubicin and mitoxantrone
Orientador
 Mariana Ferreira (Mestrado)
Universidade de Aveiro Departamento de Química, Portugal
2021/07/23 Insights on the molecular targets of anticancer drugs-induced cardiotoxicity: a systematic review based on proteomics findings
Orientador
 Sofia Brandão (Outro)
Faculty of Pharmacy University of Porto, Portugal
2021/06/21 Nano-based drug delivery systems used as vehicles of polyphenols for diabetes mellitus treatment
Arguente principal
 Adelaide Patrícia Teles de Sousa intitulado (Outro)
Faculty of Pharmacy University of Porto, Portugal
2020/12/11 The neurotoxicity of doxorubicin and mitoxantrone: chemobrain studies using infant, adult, and old mice
Orientador
 Ana Rita Dias Carvalho (Mestrado)
Faculty of Pharmacy of University of Porto, Portugal
2020/12/09 Biomarkers of heart damage caused by cyclophosphamide: a metabolomic approach in AC16 human cardiomyocytes
Orientador
 Flávio Dionísio da Costa (Mestrado)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Faculty of Sciences University of Porto, Portugal
2020/06/21 PRO-INFLAMMATORY EFFECTS OF SILVER NANOPARTICLES IN THE INTESTINE
Arguente
 Adelaide Patrícia Teles de Sousa (Outro)
Faculty of Pharmacy University of Porto, Portugal
2020/06/08 Pro-inflammatory effects of silver nanoparticles in the intestine
Arguente principal
 Sónia Aguiar da Rocha (Outro)
Faculty of Pharmacy University of Porto, Portugal
2019/07/09 The importance of fertility preservation in cancer patients treated with ciclophosphamide
Arguente principal
 Mariana Castelõa (Outro)
Universidade do Porto Faculdade de Ciências, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2018/11/14 In vitro evaluation of antidotes for Amanita phalloides intoxications
Orientador
 Daniela Rodrigues. (Mestrado)
Universidade do Porto Faculdade de Farmácia, Portugal
2018/11/12 The influence of age on the toxicity induced by mitoxantrone: in vivo studies with mice
Orientador
 Rita Alexandra Guedes (Mestrado)
Universidade do Porto Faculdade de Farmácia, Portugal
2018/09/18 Main metabolites of 5-fluorouracil + adriamycin/doxorubicin + cyclophosphamide (FAC) are not major contributors to FAC toxicity in H9c2 cardiac differentiated cells
Orientador
 Ana Filipa Reis Mendes (Outro)
Faculty of Pharmacy University of Porto, Portugal
2018/07/12 Effects of Phytocannabinoids in human endometrium
Arguente principal
 Patrícia Manuela Fonseca Malheiro (Outro)
Universidade do Porto Faculdade de Farmácia, Portugal
2018/07/10 The influence of doxorubicin and mitoxantrone on the redox status of the brain of differently aged mice
Orientador
 Ana Rita Dias de Carvalho (Outro)
Universidade do Porto Faculdade de Ciências, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2017/07/06 A cytotoxicity study of pixantrone in non-differentiated H9c2 cells
Orientador
 Marisa Alexandra Pinto Alves (Outro)
Universidade do Porto Faculdade de Ciências, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2017/02/16 Estratégias farmacológicas para evitar a neurotoxicidade da doxorrubicina e da mitoxantrona, em células SH-SY5Y
Orientador
 Rita Pinho (Outro)
Universidade do Porto Faculdade de Farmácia, Portugal
2016/12/06 Comparação da citotoxicidade de fármacos anticancerígenos e sua mistura em células H9c2 diferenciadas
Orientador
 Maria Rosário OLiveira (Mestrado)
Universidade de Aveiro, Portugal
2016/04/04 Estudo da citotoxicidade da doxorrubicina e da mitoxantrona em células SH-SY5Y
Orientador
 Ana Daniela Almeida (Outro)
Universidade do Porto Faculdade de Farmácia, Portugal
2015/10/09 XVI CURSO DE PÓS-GRADUAÇÃO EM MEDICINA DO TRABALHO - Final Report Evaluation
Arguente
 Andrea de Fátima Tavares Rodrigues (Outro)
Faculty of Medicine of University of Porto, Portugal
2015/10/09 XVI CURSO DE PÓS-GRADUAÇÃO EM MEDICINA DO TRABALHO - Final Report Evaluation
Arguente
 Luís Miguel Alves Carvalho dos Santos (Outro)
Faculty of Medicine of University of Porto, Portugal
2015/10/09 XVI CURSO DE PÓS-GRADUAÇÃO EM MEDICINA DO TRABALHO - Final Report Evaluation
Arguente
 Luís Miguel Ferreira de Sousa (Outro)
Faculty of Medicine of University of Porto, Portugal
2015/10/09 XVI CURSO DE PÓS-GRADUAÇÃO EM MEDICINA DO TRABALHO - Final Report Evaluation
Arguente
 Maria Mafalda Jordão da Cunha Abreu (Outro)
Faculty of Medicine of University of Porto, Portugal
2015/10/09 XVI CURSO DE PÓS-GRADUAÇÃO EM MEDICINA DO TRABALHO - Final Report Evaluation
Arguente
 Marina Manuela Dias Mesquita (Outro)
Faculty of Medicine of University of Porto, Portugal
2015/10/09 XVI CURSO DE PÓS-GRADUAÇÃO EM MEDICINA DO TRABALHO - Final Report Evaluation
Arguente
 Patrícia Borges Fernandes (Outro)
Faculty of Medicine of University of Porto, Portugal
2015/10/05 XVI CURSO DE PÓS-GRADUAÇÃO EM MEDICINA DO TRABALHO - Final Report Evaluation
Arguente
 Carlos Pedro Mendes (Outro)
Faculty of Medicine of University of Porto, Portugal
2015/10/05 XVI CURSO DE PÓS-GRADUAÇÃO EM MEDICINA DO TRABALHO - Final Report Evaluation
Arguente
 Diogo Maximiano Barros Figueiredo Ramos (Outro)
Faculty of Medicine of University of Porto, Portugal
2015/10/05 XVI CURSO DE PÓS-GRADUAÇÃO EM MEDICINA DO TRABALHO - Final Report Evaluation
Arguente
 Gonçalo Augusto Pessoa Jorge Mendes (Outro)
Faculty of Medicine of University of Porto, Portugal
2015/10/05 XVI CURSO DE PÓS-GRADUAÇÃO EM MEDICINA DO TRABALHO - Final Report Evaluation
Arguente
 João António Caldas Amorim (Outro)
Faculty of Medicine of University of Porto, Portugal
2015/10/05 XVI CURSO DE PÓS-GRADUAÇÃO EM MEDICINA DO TRABALHO - Final Report Evaluation
Arguente
 José Eduardo Monteiro Corujo Moreira Carneiro (Outro)
Faculty of Medicine of University of Porto, Portugal
2015/10/05 XVI CURSO DE PÓS-GRADUAÇÃO EM MEDICINA DO TRABALHO - Final Report Evaluation
Arguente
 Raquel Sofia Ferreira Sanches (Outro)
Faculty of Medicine of University of Porto, Portugal
2015/10/05 XVI CURSO DE PÓS-GRADUAÇÃO EM MEDICINA DO TRABALHO - Final Report Evaluation
Arguente
 Sara Isabel Almeida de Magalhães (Outro)
Faculty of Medicine of University of Porto, Portugal
2015/09/09 XVI CURSO DE PÓS-GRADUAÇÃO EM MEDICINA DO TRABALHO - Final Report Evaluation
Arguente
 Solange Teles Braga (Outro)
Faculty of Medicine of University of Porto, Portugal
2015/07/23 Avaliação da toxicidade da mitoxantrona em modelo de células neuronais SH-SY5Y
Orientador
 Verónica Correia (Outro)
Universidade do Porto Faculdade de Ciências, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2015/07/21 Efeitos do 9tetrahidrocanabinol em células do estroma do endométrio humano
Arguente principal
 José Carlos Ribeiro (Outro)
Universidade do Porto Faculdade de Ciências, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2014/11/14 The synthesis and in vitro toxicological evaluation of the mitoxantrone naphthoquinoxaline metabolite: A comparative study with the parent drug
Orientador
 Ana Filipa dos Reis Mendes (Mestrado)
Universidade do Porto Faculdade de Farmácia, Portugal
2014/10/28 Efeito de nanopartículas de prata em neutrófilos humanos
Arguente principal
 Tânia Sofia Couto Soares (Mestrado)
Universidade do Porto Faculdade de Farmácia, Portugal
2013/12/02 Toxicity of the antitumour drug mitoxantrone in pediatric and adult mice
Orientador
 José Luis Dores Sousa (Mestrado)
Universidade do Porto Faculdade de Ciências, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2013/11/11 Exposição ocupacional na manipulação de citotóxicos
Arguente principal
 Sara Afonso Mendes (Outro)
Universidade do Porto Faculdade de Farmácia, Portugal
2011/09/28 XIV CURSO DE PÓS-GRADUAÇÃO EM MEDICINA DO TRABALHO - Final Report Evaluation
Arguente
 Cláudia Sofia Gomes de Carvalho (Outro)
Faculty of Medicine of University of Porto, Portugal
2011/09/28 XIV CURSO DE PÓS-GRADUAÇÃO EM MEDICINA DO TRABALHO - Final Report Evaluation
Arguente
 João Nelson de Magalhães Teixeira (Outro)
Faculty of Medicine of University of Porto, Portugal
2011/09/28 XIV CURSO DE PÓS-GRADUAÇÃO EM MEDICINA DO TRABALHO - Final Report Evaluation
Arguente
 João Nelson de Magalhães Teixeira (Outro)
Universidade do Porto Faculdade de Medicina, Portugal
2011/09/28 XIV CURSO DE PÓS-GRADUAÇÃO EM MEDICINA DO TRABALHO - Final Report Evaluation
Arguente
 Liliana Rego Soares (Outro)
Faculty of Medicine of University of Porto, Portugal
2011/09/28 XIV CURSO DE PÓS-GRADUAÇÃO EM MEDICINA DO TRABALHO - Final Report Evaluation
Arguente
 Juan Jesús Albaladejo Roca (Outro)
Faculty of Medicine of University of Porto, Portugal
2011/09/28 XIV CURSO DE PÓS-GRADUAÇÃO EM MEDICINA DO TRABALHO - Final Report Evaluation
Arguente
 Pablo Alija Mendaña (Outro)
Faculty of Medicine of University of Porto, Portugal
2011/09/26 XIV CURSO DE PÓS-GRADUAÇÃO EM MEDICINA DO TRABALHO - Final Report Evaluation
Arguente
 Adriana Ferreira da Costa (Outro)
Faculty of Medicine of University of Porto, Portugal
2011/09/26 XIV CURSO DE PÓS-GRADUAÇÃO EM MEDICINA DO TRABALHO - Final Report Evaluation
Arguente
 Alcina Maria Barreto Ascenção Azevedo (Outro)
Faculty of Medicine of University of Porto, Portugal
2011/09/11 XIV CURSO DE PÓS-GRADUAÇÃO EM MEDICINA DO TRABALHO - Final Report Evaluation
Arguente
 Ana Cristina Mendes Moreira de Aguilar Ferreira (Outro)
Faculty of Medicine of University of Porto, Portugal
2011/09/11 XIV CURSO DE PÓS-GRADUAÇÃO EM MEDICINA DO TRABALHO - Final Report Evaluation
Arguente
 Ana Micaela da Fonseca Marinho Vaz Soares (Outro)
Faculty of Medicine of University of Porto, Portugal
2011/09/11 XIV CURSO DE PÓS-GRADUAÇÃO EM MEDICINA DO TRABALHO - Final Report Evaluation
Arguente
 André Fernandes Pinto (Outro)
Faculty of Medicine of University of Porto, Portugal
2011/09/11 XIV CURSO DE PÓS-GRADUAÇÃO EM MEDICINA DO TRABALHO - Final Report Evaluation
Arguente
 Angelina de Deus Oliveira Mendes (Outro)
Faculty of Medicine of University of Porto, Portugal
2011/09/11 XIV CURSO DE PÓS-GRADUAÇÃO EM MEDICINA DO TRABALHO - Final Report Evaluation
Arguente
 Daniela Cristina Castro Xará (Outro)
Faculty of Medicine of University of Porto, Portugal
2010/10/29 Uso de Benzodiazepinas em Idosos
Arguente principal
 João António de Oliveira Costa (Outro)
Universidade do Porto Faculdade de Farmácia, Portugal
2010/07/28 A sinefrina e o seu potencial cardiotóxico
Orientador
 Luciana Rossato (Outro)
Faculty of Pharmacy University of Porto, Portugal
2010/07/09 Estudo do transporte celular da sinefrina e da sua interacção com a glutationa em suspensão de cardiomiócitos isolados de rato adulto
Orientador
 Luciana Rossato Grazottin (Mestrado)
Universidade do Porto Faculdade de Farmácia, Portugal

Arbitragem científica em revista

Nome da revista (ISSN) Editora
2023/02 - Atual Helyion Elsevier
2022/03/01 - Atual Frontiers in Toxicology - Clinical Toxicology Frontiers
2020/02/01 - Atual Cardiovascular Toxicology (1530-7905) Springer-Verlag
2019/02/01 - Atual Brazilian Journal of Pharmaceutical Sciences (1984-8250) SciELO

Comissão de avaliação

Descrição da atividade
Tipo de assessoria 		Instituição / Organização Entidade financiadora
2024/04/01 - Atual Scientific evaluator on the 4th National Plan for Research, Development and Innovation for the period 2022-2027 (PNCDI IV) for the Romanian National Research Council (CNCS) e Executive Agency for Higher Education, Research, Development and Innovation Funding (UEFISCDI)
Avaliador
 Executive Agency for Higher Education, Research, Development and Innovation Funding, Romania., Roménia Executive Agency for Higher Education, Research, Development and Innovation Funding, Romania.
2023/12 - Atual Post Doc Grants "Rita Levi Montalcini" Young Researchers Program 2021
Avaliador
 Italian Ministry for University and Research (MUR) , Itália
2023 - Atual Evaluation of projects of University of Parma, Italy, in the programme 'Bando di Ateneo 2022 per la ricerca - Azione A: Progetti di ricerca di consolidamento o scouting'
Avaliador
 Università degli Studi di Parma, Itália Università degli Studi di Parma
2022 - Atual UO Supporto Ricerca Nazionale e Industriale, University of Parma
Avaliador
2022 - Atual Evaluation of Projects on the University of Parma, within UO Supporto Ricerca Nazionale e Industriale, University of Parma Programme. Università degli Studi di Parma, Itália Università degli Studi di Parma
2021/11/01 - Atual Scientific evaluator for the Executive Agency for Higher Education, Research, Development and Innovation Funding, Romania within PED21 Programm
Avaliador
 Executive Agency for Higher Education, Research, Development and Innovation Funding, Romania., Roménia Executive Agency for Higher Education, Research, Development and Innovation Funding, Romania.
2021/10/12 - Atual Member of the evaluation of projects for the Executive Agency for Higher Education, Research, Development and Innovation Funding (https://uefiscdi.gov.ro) under the 2021 funding call Experimental Demonstrative Project (PED2021)
Avaliador
 Executive Agency for Higher Education, Research, Development and Innovation Funding, Romania., Roménia Guvernul Romaniei Secretariatul General al Guvernului
2021/10/01 - Atual Contract with Fundacja na rzecz Nauki Polskiej, Poland for Scientific Projects Evaluation
Avaliador
 Fundacja na rzecz Nauki Polskiej, Polónia Fundacja na rzecz Nauki Polskiej
2021/09/01 - Atual Lead reviewer in projects integrated on IDEAS Programme - Serbia
Coordenador
 Science Fund of The Republic of Serbia, Sérvia Government of Serbia
2021/06/01 - Atual Scientific Evaluator integrated in the IDEAS Programme - Serbia
Avaliador
 Science Fund of The Republic of Serbia, Sérvia
2021/02/19 - Atual Event moderator in the Cardiovascular Pharmacology Section of the XLI Annual Meeting of the Portuguese Society of Pharmacology, XXXIX Meeting of Clinical Pharmacology and XX Meeting of Toxicology
Avaliador
 University of Lisboa Faculdade Farmácia, Portugal
2021 - Atual Programma per Giovani Ricercatori Rita Levi Montalcini 2019 - Pos Doc Grants
Avaliador
 Italian Ministry for University and Research (MUR) , Itália Italian Ministry for University and Research (MUR)
2021 - Atual Programme 2020 PRIN of Italian Ministry for University and Research (MUR) Scientific projects on Healh Sciences
Avaliador
 Italian Ministry for University and Research (MUR) , Itália Italian Ministry for University and Research (MUR)
2020/08/01 - Atual Evaluator of Scientific Projects at REPRISE (the Register of Scientific Experts set up at the Ministry of Education, University and Research MUR, Of Italy) for the following sections: Fundamental research Applied research Scientific popularization
Avaliador
 Italian National Agency for the Evaluation of the University and Research Systems
2024/04/01 - 2024/05/01 Scientific evaluator for the Austrian Science Fund (FWF).
Avaliador
 Fonds zur Förderung der wissenschaftlichen Forschung, Áustria Fonds zur Förderung der wissenschaftlichen Forschung
2023/03/20 - 2023/10/31 Scientific evaluator for the Executive Agency for Higher Education, Research, Development and Innovation Funding, Romania within the Recovery and Resilience Plan for Romania (PNRR): Investment 8. (F-PNRR-I8-2022 e F-PNRR-I8-2023 ). Development of a program to attract highly specialized human resources from abroad in research, development and innovation activities.
Avaliador
 Executive Agency for Higher Education, Research, Development and Innovation Funding, Romania., Roménia Executive Agency for Higher Education, Research, Development and Innovation Funding, Romania.
2023/07 - 2023/10/15 Scientific Evaluator integrated in the Program for Excellent Projects of Young Researchers and Scientists in the Early Stage of Career - PROMIS 2023. (Serbia)
Avaliador
 Science Fund of The Republic of Serbia, Sérvia Science Fund of The Republic of Serbia
2020/02/12 - 2020/02/14 Member of the Scientific Evaluation Committee in 13º Encontro de Investigação Jovem da Universidade do Porto, University of Porto, Porto.
Avaliador
 Universidade do Porto, Portugal
2020/02/05 - 2020/02/07 Event moderator in the Cardiovascular Pharmacology Section of the XL Annual Meeting of the Portuguese Society of Pharmacology, XXXVIII Meeting of Clinical Pharmacology and XIX Meeting of Toxicology
Outro
 Sociedade Portuguesa de Farmacologia, Portugal
2020 - 2020 Programa Progetti di ricerca COVID-19 - comunicazione attività di valutazione ex ante (Avviso D.D. 562/2020) - FISR2020 Covid-19 evaluations Scientific projects under COVID
Avaliador
 Italian Ministry for University and Research (MUR) , Itália Italian Ministry for University and Research (MUR)
2019/02/06 - 2019/02/08 Event moderator in the Toxicology I Section of the XLIX Annual Meeting of the Portuguese Society of Pharmacology, XXXVII Meeting of Clinical Pharmacology and XVIII Meeting of Toxicology
Outro
 Sociedade Portuguesa de Farmacologia, Portugal
2017/02/02 - 2017/02/04 Event moderator in the Toxicology II Section of the XVII Annual Meeting of the Portuguese Society of Pharmacology, XXXV Meeting of Clinical Pharmacology and XVI Meeting of Toxicology
Outro
 Sociedade Portuguesa de Farmacologia, Portugal

Consultoria / Parecer

Descrição da atividade Instituição / Organização
2024 - Atual Mentor for the DIANA programme NATO, Bélgica
2023/02 - Atual Member of the 4UNCAN.eu: a European initiative to better understand cancer https://ccieurope.eu/uncan-eu-better-understand-cancer/ European Union, Bélgica
2023 - Atual Member of Phase 4 of a European Organisation for Research and Treatment of Cancer (EORTC) project for a survivorship questionnaire European Organisation for Research and Treatment of Cancer (EORTC) , Bélgica
2022 - Atual Expert for UNICAN.EU “A European initiative to UNderstand CANcer'. An initiative to better UNderstand CANcer (UNCAN.eu) is part of the implementation roadmap of two programs of the European Union (EU), Europe’s Beating Cancer Plan and the Horizon Europe Mission on Cancer. European Union, Bélgica
2021/12/15 - Atual External Expert Open Call OC-2021-1 of COST (Reserve List) European Cooperation in Science and Technology, Bélgica
2021 - Atual Foundation for Polish Science Smart Growth Operational Programme Fundacja na rzecz Nauki Polskiej, Polónia
2021 - Atual Consulting for scientific projects and grants for the Executive Agency for Higher Education, Research, Development and Innovation Funding, Romania Executive Agency for Higher Education, Research, Development and Innovation Funding, Romania., Roménia
2020/11/20 - Atual Evaluation Committe Review of projects submitted to the Science Fund of the Republic of Serbia
2020 - Atual Evaluation Committe Review of projects submitted to the Italian Science Ministry of Italy REPRISE (the Register of Scientific Experts set up at the MIUR), Itália
2019 - Atual External Advisor for Global Burden of Disease Studies (GBD) Institute for Health Metrics and Evaluation (IHME), University of Washington, Estados Unidos

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2020/05/22 - Atual Invited lecturer at the Graduate Program of Bioexperimentação, Universidade de Passo Fundo, Brazil. Graduate Program of Bioexperimentação Universidade de Passo Fundo, Brasil

Entrevista (jornal / revista)

Descrição da atividade Jornal / Forum
2023/06/27 News article about research in Portugal. Full title: As histórias dos investigadores que podem ficar sememprego de um dia para o outro Observador

Membro de associação

Nome da associação Tipo de participação
2007 - Atual Sociedade Portuguesa de Farmacologia Member
2004 - Atual Ordem dos Farmacêuticos Member of The Portuguese College of Pharmacists

Membro de comissão

Descrição da atividade
Tipo de participação 		Instituição / Organização
2023/03/09 - Atual Coordinator of Working Group (Impact) of UCIBIO Main objectives: 1.Industry and Organizations Liaison 2.Exploitation 3. Outreach & Science communication
Coordenador
 REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
2023/03/09 - Atual Executive Committee Member of UCIBIO - Porto
Membro
 REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
2023/03 - Atual Coordination Committee Member of UCIBIO
Membro
 REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
2022 - Atual Vice-coordinator of the Stakeholders Group of National Cancer HUB (Survivors Group), an organization held by Agência de Investigação Clínica e Inovação Biomédica and Direção Geral da Saúde.
Presidente / Vice-presidente
 Agência de Investigação Clínica e Inovação Biomédica, Portugal

Direção Geral da Saúde, Portugal

Outro júri / avaliação

Descrição da atividade Instituição / Organização
2019/05/19 - Atual Member in the selection for a candidate for a scholarship in the project "Development of antidotes for Amanita phalloides intoxications, from in silico to the intoxicated patient" (PTDC / DTP-FTO / 4973/2014 - POCI-01-0145-FEDER-016545, funded by the Science Foundation and Technology) at the ICETA-Toxicology Laboratory, Faculty of Pharmacy, University of Porto, Portugal. Referência ICETA 2019-39. REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal

Universidade do Porto Instituto de Ciências e Tecnologias Agrárias e Agro-Alimentares, Portugal
2018/07/23 - Atual Member and President in the selection for a candidate for a scholarship in the project "Poisoning the heart with anticancer drugs: is metabolic bioactivation or aging promotion the link to the cardiotoxicity of anticancer drugs?” (PTDC / DTP-FTO / 1489/2014 - POCI-01-0145-FEDER-016537), funded by the Science Foundation and Technology) at the ICETA-Toxicology Laboratory, Faculty of Pharmacy, University of Porto, Portugal. REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal

Universidade do Porto Instituto de Ciências e Tecnologias Agrárias e Agro-Alimentares, Portugal
2017/09/11 - Atual Member in the selection for a candidate for a scholarship in the project "Development of antidotes for Amanita phalloides intoxications, from in silico to the intoxicated patient" (PTDC / DTP-FTO / 4973/2014 - POCI-01-0145-FEDER-016545, funded by the Science Foundation and Technology) at the ICETA-Toxicology Laboratory, Faculty of Pharmacy, University of Porto, Portugal. Universidade do Porto Instituto de Ciências e Tecnologias Agrárias e Agro-Alimentares, Portugal

REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
2017/01/30 - Atual Member of the Jury to select candidates Portuguese students from the University of Porto who would attend the Cardiopulmonary Toxicity Course in Hradec Králové (Czech Republic). Faculty of Pharmacy University of Porto, Portugal
2016/12/21 - Atual Member and President in the selection for a candidate for a scholarship in the project "Poisoning the heart with anticancer drugs: is metabolic bioactivation or aging promotion the link to the cardiotoxicity of anticancer drugs?” (PTDC / DTP-FTO / 1489/2014 - POCI-01-0145-FEDER-016537), funded by the Science Foundation and Technology) at the ICETA-Toxicology Laboratory, Faculty of Pharmacy, University of Porto, Portugal. Universidade do Porto Instituto de Ciências e Tecnologias Agrárias e Agro-Alimentares, Portugal

REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
2014/04/16 - Atual Member and President in the selection for a candidate for a scholarship in the project "Why is mitoxantrone a poison to the heart? Focus on mitochondria, cytoskeleton, and metabolic bioactivation mechanisms.” (EXPL/DTP-FTO/0290/2012), funded by the Science Foundation and Technology and FEDER at the ICETA-Toxicology Laboratory, Faculty of Pharmacy, University of Porto, Portugal. Universidade do Porto Instituto de Ciências e Tecnologias Agrárias e Agro-Alimentares, Portugal
2013/02 - Atual Member in the selection for a candidate for a scholarship in the project "CONSEQUÊNCIAS DO CONSUMO RECREATIVO DE PSICOESTIMULANTES ANFETAMINICOS NO ENVELHECIMENTO CEREBRAL" (PTDC/SAU-FCF/102958/2008), funded by the Science Foundation and Technology and COMPETE) at the ICETA-Toxicology Laboratory, Faculty of Pharmacy, University of Porto, Portugal. Universidade do Porto Instituto de Ciências e Tecnologias Agrárias e Agro-Alimentares, Portugal

REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
2011/07/25 - Atual Member in the selection for a candidate for a scholarship in the project "CONSEQUÊNCIAS DO CONSUMO RECREATIVO DE PSICOESTIMULANTES ANFETAMINICOS NO ENVELHECIMENTO CEREBRAL" (PTDC/SAU-FCF/102958/2008), funded by the Science Foundation and Technology and COMPETE) at the ICETA-Toxicology Laboratory, Faculty of Pharmacy, University of Porto, Portugal. Universidade do Porto Instituto de Ciências e Tecnologias Agrárias e Agro-Alimentares, Portugal

REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal

Revisão ad hoc de artigos em revista

Nome da revista (ISSN) Editora
2023/10/23 - Atual Archives of Toxicology Springer
2023/10/21 - Atual Biochemical Pharmacology Elsevier
2023/09/25 - Atual Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease Elsevier
2023/01/23 - Atual Nature Communications Nature
2019/01/10 - Atual Food and Chemical Toxicology Elsevier
2018/08/28 - Atual Cardiovascular Toxicology (15590259) Springer
2018/06/22 - Atual Human & Experimental Toxicology SAGE
2017/09/14 - Atual Toxicology and Applied Pharmacology Elsevier
2017/02/25 - Atual Free Radical Biology and Medicine Elsevier
2010/07/27 - Atual Toxicology Elsevier
2018/01 - 2022/07/27 Food and Chemical Toxicology Elsevier
2021/01/01 - 2021/12/15 Biomolecules (ISSN 2218-273X) MDPI

Tutoria

Tópico Nome do aluno
2022/07 - Atual "Verão com Ciência" 2022 Patrícia Rodrigues
2020/09/01 - Atual Final Scientific Report Supervision of the experimental Project within the Biochemistry Degree, Instituto de Ciências Biomédicas Abel Salazar and Sciencies Faculty, Universidade do Porto. Ana Olívia Fernandes
2020/09/01 - Atual Final Scientific Report Supervision of the experimental Project within the Biochemistry Degree, Instituto de Ciências Biomédicas Abel Salazar and Sciencies Faculty, Universidade do Porto. Maria Francisca Espincho
2022/09/01 - 2022/11/30 ERASMUS Hugo Filipe Costa Almeida
2022/07/18 - 2022/07/29 Summer Student Exchange Program (SEP) 2022 Tomasz Ciecielag
2022/07/18 - 2022/07/29 Summer Student Exchange Program (SEP) 2022 Luca Éva Uhljar
2021/03/29 - 2021/09/30 ERASMUS Mobility Elisa Milandri
2019/09/15 - 2020/01/31 ERASMUS Mobility Marina Sanchez Momblona
2019/07 - 2019/07 Summer Student Exchange Program (SEP) 2019 Andjela Ustevic
2019/07 - 2019/07 Summer Student Exchange Program (SEP) 2019 Ivana Jovanovic
2019/07 - 2019/07 Summer Student Exchange Program (SEP) 2019 Ioana Petenchiu
2018/02/28 - 2018/07/10 Final Scientific Report Biochemistry Degree Ana Rita Dias de Carvalho
2018/07 - 2018/07 Summer Student Exchange Program (SEP) 2018 Tamara Blagojenic
2018/07 - 2018/07 Summer Student Exchange Program (SEP) 2018 Vanja Visnjce
2017/02/28 - 2017/06/06 Final Scientific Report Marisa Alexandra Pinto Alves
2015/10/01 - 2017/03/04 Project I Ana Daniela Almeida
2016/10/01 - 2017/02/16 Project I Rita Pinho
2015/09/01 - 2016/01/31 International Mobility Joana Schuelter Boeing
2015/02/28 - 2015/07/25 Final Scientific Report Verónica Correia
2015/02/01 - 2015/02/28 International Mobility Maria Regenjo Vasquez
2014/02/28 - 2014/06/14 Final Degree Report Rute Português Eleutério
2012/02/01 - 2012/06/30 ERASMUS Mobility Krishnaa Pandya
2012/02/01 - 2012/06/06 ERASMUS Mobility Kulvir Grewald
Distinções

Prémio

2024 IACOBUS - PUBLICACIÓNS CIENTÍFICAS 2023-2024
Euroregião Galicia – Norte de Portugal Region, Espanha
2023 Best oral Presentation in Research in Symposium of the Faculty of Pharmacy of the University of Porto 2023
Associação de Estudantes Faculdade de Farmácia Universidade do Porto, Portugal
2023 Best Poster Awarded
2022 Best Oral Presentation in Biosystems in Toxicology and Pharmacology - Current challenges
“Biosystems in Toxicology and Pharmacology – Current challenges”, Suiça
2022 Best oral Presentation in Research Symposium of the Faculty of Pharmacy of the University of Porto 2022
Associação de Estudantes Faculdade de Farmácia Universidade do Porto, Portugal
2021 Best Poster
Organization of XII Biochemistry Day, The Biochemistry of SARS-CoV-2, Portugal
2021 3rd prize on the Best Free Communication Award.
Organization of III Jornadas Ibéricas de Toxicologia. Universidade da Beira Interior, Portugal
2020 Second prize for best oral presentation
Faculty of Pharmacy University of Porto, Portugal

Simpósio de Investigação da Faculdade de Farmácia da Universidade do Porto , Portugal
2019 Top Reviewer 2019 on Toxicology and Pharmacology
Clarivate Analytics Deutschland GmbH, Alemanha
2019 Top Reviewer 2019 in Cross Field
Clarivate Analytics Deutschland GmbH, Alemanha
2015 Pos Doc Grant
Fundação da Ciência e Tecnologia, Portugal
2015 Pedagogic award
Faculty of Pharmacy University of Porto, Portugal
2014 Best Poster
Universidade Nova de Lisboa, Portugal
2014 Highly Commended recognition Gerhard-Zbinden Young Scientist Award
Federation of European Toxicologists & European Societies of Toxicology, Suiça
2013 Selection to be cover of Chemical Research in Toxicology
ACS Publications, Estados Unidos
2009 Pos Doc Grant
Fundação da Ciência e Tecnologia, Portugal
2007 Best Poster
Portuguese Network (Procura), Portugal
2003 Merit Grant 2003 of Best Student
Universidade do Porto Faculdade de Farmácia, Portugal
1995 Best student
Rotary Club Fafe, Portugal

Outra distinção

2023 Selected presentation and monetary traveling award for XXV Conference of Young SIF Pharmacologists 2023
Sociedade Portuguesa de Farmacologia, Portugal

Società Italiana di Farmacologia, Itália
2022 Rapporteur for the evaluation of Scientific International Projects of Romania
Executive Agency for Higher Education, Research, Development and Innovation Funding, Romania., Roménia
2022 Honorable mention
Students of the Academic Association of the University of Aveiro (NEQ), Portugal
2022 UCIBIO Research Unit Researchers Evaluation for 2019-2021
REQUIMTE LAQV Porto, Portugal
2021 Lead Reviewer
Science Fund of The Republic of Serbia, Sérvia
2021 Short List for Best Poster EUROTOX 2021
56th Congress of The European Societies of Toxicology, Dinamarca
2021 Short List for Best Poster EUROTOX 2021
56th Congress of The European Societies of Toxicology, Dinamarca
2021 Honorable mention
Organization of XII Biochemistry Day, The Biochemistry of SARS-CoV-2, Portugal