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Patrícia H. Brito, is an independent researcher at the Universidade Nova de Lisboa, UCIBIO, FCT, and an Invited Assistance Professor at the NOVA Medical School (UNL). The main focus of her research is on the study of microbial genome evolution mainly in the context of host-microbe interactions both in health and in disease, where she applies evolutionary genomics methodologies to understand the causes of genome diversity. She was awarded a Fulbright fellowship to pursue her doctoral studies in the US. She completed her Ph.D. in Biology in 2006 on a joint program of the City University of New York and the American Museum of Natural History, on population genetics, phylogeography, and phylogenetics under the supervision of G. Barrowclough. She pursued her research at the lab of S.V. Edwards at Harvard University. After maternal leave she resumed her research at Instituto Gulbenkian de Ciência, Portugal, for postdoctoral research at the Evolutionary Biology lab of I. Gordo and later at the Comparative Genomics lab of J. Pereira-Leal. From 2018-2019 she worked as an independent researcher at the Research Center for Chronic Diseases (CEDOC, Universidade Nova de Lisboa) collaborating with several research groups performing bioinformatic analyses using multi-omic approaches. On 2019 she joins the Yeast Genomics lab at the UCIBIO-FCT (Universidade Nova de Lisboa) as an independent researcher. She has authored 22 publications, being first and/or corresponding authors in 8, single author in 2, and last senior author in 2 publications. She has a total of 942 citations (Google Scholar) that results in a H index of 11. She is currently co- supervising 3 PhD. students and participates, or participated, as Research Fellow in 12 projects, where she has been responsible for performing or supervising the evolutionary bioinformatic analyses. She is interested in the application of evolutionary theory to understand the causes of human diseases, and she is has been very active on the field of Evolutionary Medicine. She introduced a new elective course on Evolutionary Medicine at the Integrated Masters of Medicine (NOVA Medical School, UNL), and organized a symposium on Evolution and Cancer at the Champalimaud Center in Lisbon. Since 2015 she is a member of the Education and Outreach Committee of the International Society for the Evolution, Medicine, and Public Health. Patrícia H. Brito is also deeply committed to teaching and mentorship. She has had the opportunity to teach both undergraduate and graduate level courses in several universities, both in Portugal (Universidade Nova de Lisboa, Universidade Católica Portuguesa, Instituto Gulbenkian de Ciência) and in the US (Harvard University, City University of New York). She was involved in the planning, organization, and teaching of a new Master in Computational Biology offered at NOVA University.
Identificação

Identificação pessoal

Nome completo
Patrícia Filipa Homem de Campos Tavares de Brito

Identificadores de autor

Ciência ID
5E18-4CEC-E693
ORCID iD
0000-0002-2457-7520
Google Scholar ID
https://scholar.google.com/citations?user=WlmG2MYAAAAJ&hl=pt-PT&authuser=1
Scopus Author Id
57216175171

Moradas

  • UCIBIO-REQUIMTE, Departamento de Cie^ncias da Vida, Faculdade de Cie^ncias e Tecnologia, Universidade Nova de Lisboa. Campus de, Caparica, 2829-516 C, Caparica, Almada, Portugal (Profissional)

Domínios de atuação

  • Ciências Naturais - Ciências Biológicas - Biologia da Evolução das Espécies
  • Ciências Exatas - Ciências da Computação e da Informação - Bioinformática
Formação
Grau Classificação
2006/02/01
Concluído
Biology (Doctor of Philosophy)
Especialização em Ecology, Evolution and Behavior
City University of New York, Estados Unidos
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento
Empregador
2019 - Atual Investigador (Investigação) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento
Empregador
2013 - Atual Professor Auxiliar Convidado (Docente Universitário) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
Produções

Publicações

Artigo em revista
  1. Brandão, Ana S; Borbinha, Jorge; Pereira, Telmo; Brito, Patrícia H; Lourenço, Raquel; Bensimon-Brito, Anabela; Jacinto, Antonio. "A regeneration-triggered metabolic adaptation is necessary for cell identity transitions and cell cycle re-entry to support blastema formation and bone regeneration". eLife 11 (2022): http://dx.doi.org/10.7554/elife.76987.
    10.7554/elife.76987
  2. Alves-Barroco, Cinthia; Brito, Patrícia H.; Santos-Sanches, Ilda; Fernandes, Alexandra R.. "Phylogenetic analysis and accessory genome diversity reveal insight into the evolutionary history of Streptococcus dysgalactiae". Frontiers in Microbiology 13 (2022): http://dx.doi.org/10.3389/fmicb.2022.952110.
    10.3389/fmicb.2022.952110
  3. Silva, Margarida; Pontes, Ana; Franco-Duarte, Ricardo; Soares, Pedro; Sampaio, José Paulo; Sousa, Maria João; Brito, Patrícia H.. "A glimpse at an early stage of microbe domestication revealed in the variable genome of Torulaspora delbrueckii , an emergent industrial yeast". Molecular Ecology (2022): http://dx.doi.org/10.1111/mec.16428.
    10.1111/mec.16428
  4. Santos, Ana Raquel Oliveira; Aires, Andreia; Pontes, Ana; Silva, Margarida; Brito, Patricia H; Groenewald, Marizeth; Melo, Cidiane G. S.; et al. "Phaffia brasiliana sp. nov., a yeast species isolated from soil in a Cerrado–Atlantic Rain Forest ecotone site in Brazil". International Journal of Systematic and Evolutionary Microbiology 71 11 (2021): http://dx.doi.org/10.1099/ijsem.0.005080.
    10.1099/ijsem.0.005080
  5. Cabrita, Alexandra; David-Palma, Márcia; Brito, Patrícia H.; Heitman, Joseph; Coelho, Marco A.; Gonçalves, Paula. "Multiple Pathways to Homothallism in Closely Related Yeast Lineages in the Basidiomycota". mBio 12 1 (2021): http://dx.doi.org/10.1128/mbio.03130-20.
    10.1128/mbio.03130-20
  6. Márcia David-Palma; Diego Libkind; Patricia H. Brito; Margarida Ribeiro da Silva; Nicolas Bellora; Márcia David-Palma; Joseph Heitman; Paula Gonçalves; José Paulo Sampaio. "The Untapped Australasian Diversity of Astaxanthin-Producing Yeasts with Biotechnological Potential—Phaffia australis sp. nov. and Phaffia tasmanica sp. nov.". Microorganisms (2020): https://www.mdpi.com/2076-2607/8/11/1651.
    Publicado • 10.3390/microorganisms8111651
  7. Pontes, Ana; Hutzler, Mathias; Brito, Patrícia H.; Sampaio, José Paulo. "Revisiting the Taxonomic Synonyms and Populations of Saccharomyces cerevisiae—Phylogeny, Phenotypes, Ecology and Domestication". Microorganisms 8 6 (2020): 903. http://dx.doi.org/10.3390/microorganisms8060903.
    Publicado • 10.3390/microorganisms8060903
  8. Gonçalves, Paula; Gonçalves, Carla; Brito, Patrícia H.; Sampaio, José Paulo. "The Wickerhamiella/Starmerella clade—A treasure trove for the study of the evolution of yeast metabolism". Yeast 37 4 (2020): 313-320. http://dx.doi.org/10.1002/yea.3463.
    Publicado • 10.1002/yea.3463
  9. Torcato, Inês M.; Kasal, Meghann R.; Brito, Patrícia H.; Miller, Stephen T.; Xavier, Karina B.. "Identification of novel autoinducer-2 receptors in Clostridia reveals plasticity in the binding site of the LsrB receptor family". Journal of Biological Chemistry 294 12 (2019): 4450-4463. http://dx.doi.org/10.1074/jbc.ra118.006938.
    Publicado • 10.1074/jbc.ra118.006938
  10. Brito, Patrícia H; Chevreux, Bastien; Serra, Cláudia R; Schyns, Ghislain; Henriques, Adriano O; Pereira-Leal, José B. "Genetic Competence Drives Genome Diversity in Bacillus subtilis". Genome Biology and Evolution 10 1 (2017): 108-124. http://dx.doi.org/10.1093/gbe/evx270.
    Publicado • 10.1093/gbe/evx270
  11. Gjini, Erida; Brito, Patricia H.. "Integrating Antimicrobial Therapy with Host Immunity to Fight Drug-Resistant Infections: Classical vs. Adaptive Treatment". PLOS Computational Biology 12 4 (2016): e1004857. http://dx.doi.org/10.1371/journal.pcbi.1004857.
    Publicado • 10.1371/journal.pcbi.1004857
  12. Ramos-Silva, Paula; Brito, Patrícia H.; Serrano, Mónica; Henriques, Adriano O.; Pereira-Leal, José B.. "Rethinking the Niche of Upper-Atmosphere Bacteria: Draft Genome Sequences of Bacillus aryabhattai C765 and Bacillus aerophilus C772, Isolated from Rice Fields". Genome Announcements 3 2 (2015): http://dx.doi.org/10.1128/genomea.00094-15.
    Publicado • 10.1128/genomea.00094-15
  13. Brito, Patrícia H.; Rocha, Eduardo P.C.; Xavier, Karina B.; Gordo, Isabel. "Natural Genome Diversity of AI-2 Quorum Sensing in Escherichia coli: Conserved Signal Production but Labile Signal Reception". Genome Biology and Evolution 5 1 (2012): 16-30. http://dx.doi.org/10.1093/gbe/evs122.
    Publicado • 10.1093/gbe/evs122
  14. Brito, Patricia H; Guilherme, Elsa; Soares, Helena; Gordo, Isabel. "Mutation accumulation in Tetrahymena". BMC Evolutionary Biology 10 1 (2010): 354. http://dx.doi.org/10.1186/1471-2148-10-354.
    Publicado • 10.1186/1471-2148-10-354
  15. Pereira, Catarina S.; de Regt, Anna K.; Brito, Patri´cia H.; Miller, Stephen T.; Xavier, Karina B.. "Identification of Functional LsrB-Like Autoinducer-2 Receptors". Journal of Bacteriology 191 22 (2009): 6975-6987. http://dx.doi.org/10.1128/jb.00976-09.
    Publicado • 10.1128/jb.00976-09
  16. Brito, Patrícia H (5E18-4CEC-E693); Edwards, SV. "Multilocus phylogeography and phylogenetics using sequence-based markers". Genetica 135 3 (2009): 439-455.
    Publicado • 10.1007/s10709-008-9293-3
  17. Brito, Patrícia H (5E18-4CEC-E693). "Contrasting patterns of mitochondrial and microsatellite genetic structure among Western European populations of tawny owls (Strix aluco)". Molecular Ecology 16 16 (2007): 3423-3437.
    Publicado • 10.1111/j.1365-294X.2007.03401.x
  18. Brito, Patrícia H (5E18-4CEC-E693). "The influence of Pleistocene glacial refugia on tawny owl genetic diversity and phylogeography in western Europe". Molecular Ecology 14 10 (2005): 3077-3094.
    Publicado • 10.1111/j.1365-294X.2005.02663.x
Pré-impressão
  1. Ana T. Matias; Ana Jacinta-Fernandes; Ana-Teresa Maia; Sofia Braga; António Jacinto; M. Guadalupe Cabral; Brito, Patrícia H.. "Differential expression between African-ancestry and White patients diagnosed with Triple-Negative Breast Cancer: EGFR, Myc, Bcl2 and ß-Catenin as ancestry-associated markers". Pré-impressão. 2022. https://doi.org/10.1101/2020.11.13.381608.
  2. Neuza Domingues; Rita Diogo Almeida Calado; Patrícia H. Brito; Rune Matthiesen; José Ramalho; Maria I. L. Soares; Telmo Pereira; et al. "Cholesteryl Hemiazelate Induces Lysosome Dysfunction and Exocytosis in Macrophages". Pré-impressão. 2021. https://doi.org/10.1101/2021.01.05.422575.
    https://doi.org/10.1101/2021.01.05.422575
  3. Marques, Graça S.; Teles-Reis, José; Konstantinides, Nikolaos; Brito, Patrícia H.; Homem, Catarina C. F.. "Fate transitions in Drosophila neural lineages: a single cell road map to mature neurons.". Pré-impressão. 2021. http://dx.doi.org/10.1101/2021.06.22.449317.
    10.1101/2021.06.22.449317
  4. Wilson, A; Pereira, FC; Feliciano, C; Saujet, L; Vultos, T; Couture-Tosi, E; Péchiné, S; et al. "Structure and assembly of a Clostridioides difficile spore polar appendage". Pré-impressão. 2020. http://dx.doi.org/10.1101/468637.
    10.1101/468637
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2021/08/23 Evolution of opportunistic pathogenicity in S. cerevisiae. Conference on Yeasts Genetics and Molecular Biology
Vienna, AUSTRIA (virtual meeting) (virtual meeting, Áustria)
2016 Genome dynamics of a generalist microbe: competence for transformation generates stochastic variation and an open pangenome in Bacillus subtilis. 17th meeting Portugaliae genetica
I3S, Universidade do Porto (Porto, Portugal)
2015 Genomic dynamics in Bacillus subtilis, patterns of niche adaptation and domestication. 8th International conference on gram-positive microorganisms; 18th international conference on Bacilli.
Montecatini Terme (Tuscany, Itália)
2015 Challenges of first-time teaching Evolutionary Medicine at a medical school. The international Society for Evolution, Medicine and Public Health. Inaugural meeting.
ASU Center for Evolution and Medicine, Arizona State University (Tempe, Estados Unidos)
2014 Genomic dynamics in Bacillus subtillis, niche adaptation through gene gain and loss Mini-symposium, Biology and applications of a gut strain of Bacillus subtilis
Universidade Nova de Lisboa - Instituto de Tecnologia Quimica e Biológica (Oeiras, Portugal)
2006 Contrasting patterns of genetic structure among western European populations of tawny owls based on mitochondrial and nuclear markers. Evolution meeting
Stony Brook University (Stony Brook, NY, Estados Unidos)
2004 The influence of glacial refugia on Tawny owl genetic diversity. Phylogeography in Western Europe. Biology Department Seminar Series
Long Island University (NY, Estados Unidos)
2003 Do cold-adapted species require Pleistocene refugia? Phylogeographic history of the ruffed grouse in North America Evolution meeting
California State University (Chico, CA, Estados Unidos)

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação)
Instituição / Organização
2014 - Atual Symposium on Evolution and Cancer (2014)
Simpósio (Presidente da Comissão Organizadora)
Fundação Champalimaud, Portugal

Instituto Gulbenkian de Ciência, Portugal

Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

Associação Portuguesa de Biologia Evolutiva (APBE), Portugal
2022/08/05 - 2022/08/08 Seventh Annual Meeting of the International Society for Evolution, Medicine, and Public Health (2022/08/05 - 2022/08/08)
Conferência (Membro da Comissão Científica)
NOVA Medical School, UNL & Instituto Gulbenkian de Ciência, Portugal

Júri de grau académico

Tema
Tipo de participação
Nome do candidato (Tipo de grau)
Instituição / Organização
2022/01/17 Influence of peptidoglycan amidation on lysozyme resistance in Staphylococcus aureus
Arguente principal
Ana Catarina Laço Fanico (Mestrado)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2019/06/17 Exploring the factors underlying Staphylococcus epidermidis' pathogenicity
Arguente
Diana Sofia Pereira Espadinha de Oliveira Costa (Doutoramento)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2016/12/16 Microbe domestication and the identification of the wild genetic stock of wine yeasts
Arguente
Pedro Miguel Coelho de Almeida (Doutoramento)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Arbitragem científica em conferência

Nome da conferência Local da conferência
2022/07/05 - 2022/07/07 INTERNATIONAL SOCIETY FOR EVOLUTION, MEDICINE & PUBLIC HEALTH. NOVA Medical School, Instituto Gulbenkian de Ciência

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2020 - Atual Genomics in Medical Microbiology Master in Medical Microbiology (Mestrado) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2013 - Atual Evolutionary Medicine Integrated Master in Medicine (Mestrado integrado) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal