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Identificação

Identificação pessoal

Nome completo
Federica Montanaro

Identificadores de autor

Ciência ID
551B-A588-AD27
Formação
Grau Classificação
1999
Concluído
Ph.D. in Biology with specialization in Neurobiology (Doctor)
McGill University, Canadá
"The role of dystroglycan in muscular dystrophy and synaptogenesis." (TESE/DISSERTAÇÃO)
Dean’s Honour
1991
Concluído
Biology (Bachelor)
Especialização em Neurobiolgy
McGill University Department of Biology, Canadá
Distinction
1988
Concluído
French Baccalauréat (Bachelor)
École Française de Zurich, Suiça
Distinction
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento
Empregador
2016/01/01 - Atual Investigador principal (carreira) (Investigação) University College London Institute of Child Health, Reino Unido
University College London- Institute of Child Health- Dubowitz Neuromuscular Unit, Reino Unido
2016/01/01 - 2017/12/31 Investigador principal (carreira) (Investigação) EU Framework Programme for Research and Innovation Marie Sklodowska-Curie Actions, Bélgica
University College London- Institute of Child Health- Dubowitz Neuromuscular Unit, Reino Unido
2005/08 - 2015/12/31 Investigador principal (carreira) (Investigação) The Research Institute at Nationwide Children’s Hospital, Estados Unidos
The Research Institute at Nationwide Children’s Hospital- Center for Gene Therapy, Estados Unidos
1999/11 - 2005/08 Pós-doutorado (Investigação) Boston Children's Hospital and Harvard Medical School, Estados Unidos
Department of Genetics, Boston Children's Hospital and Harvard Medical School, Estados Unidos

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento
Empregador
2008/08 - 2015/12/31 Professor Auxiliar (Docente Universitário) The Ohio State University, Estados Unidos
The Ohio State University Department of Physiology and Cell Biology, Estados Unidos
2005 - 2014 Professor Auxiliar (Docente Universitário) The Ohio State University College of Medicine, Estados Unidos
The Ohio State University College of Medicine- Department of Pediatrics, Estados Unidos
Projetos

Bolsa

Designação Financiadores
2020/01 - Atual BIND: Brain involvement in Dystrophinopathies
847826
SC1-BHC-01-2019
Investigador
Great Ormond Street Hospital For Children NHS Foundation Trust, Reino Unido
European Commission
Em curso
2020/01 - Atual Restoring dystrophin expression in brain to improve behavioural and emotional problems in Duchenne muscular dystrophy
Investigador
University College London- Great Ormond Street Institute of Child Health , Reino Unido
Sarepta Therapeutics
Em curso
2020/01 - Atual Characterisation and disease relevance of a novel interaction between cardiac dystrophin and cavins
Investigador responsável
University College London- Great Ormond Street Institute of Child Health , Reino Unido
Muscular Dystrophy UK
Em curso
2019/10 - Atual SINEUPs: Novel tool with transformative potential to rescue physiological function in disease
Investigador responsável
University College London- Great Ormond Street Institute of Child Health , Reino Unido
F Hoffmann-La Roche AG
Em curso
2017/11 - Atual Characterization of a novel interaction of dystrophin with caveolae in the heart
Investigador responsável
University College London- Great Ormond Street Institute of Child Health , Reino Unido
Muscular Dystrophy UK
Em curso
2018/01 - 2021/03 Rational design of dystrophin gene therapy constructs to enhance cardiac protection in DMD
Investigador responsável
University College London Institute of Child Health, Reino Unido
Duchenne Parent Project
Concluído
2017/07 - 2019/12 Use of Abnormal Protein Expression to Improve Prognostication and Treatment Study Design in Nemaline Myopathy
Investigador
A Foundation Building Strength
Concluído
2018/11 - 2019/10 Establishment and characterization of the first iPSC model of merosin-deficient congenital muscular dystrophy
Investigador responsável
University College London- Great Ormond Street Institute of Child Health , Reino Unido
Great Ormond Street Hospital Biomedical Research center
Concluído
2018/09 - 2019/08 Pilot study of cardiac disease associated proteins in exosomes from Duchenne muscular dystrophy patients
Investigador responsável
University College London- Great Ormond Street Institute of Child Health , Reino Unido
Great Ormond Street Hospital Biomedical Research center
2016/11 - 2018/10 Predicting the impact of exon skipping on dystrophin function
Investigador responsável
Muscular Dystrophy UK
Concluído
2016/01/01 - 2017/12 Novel use of exon skipping technology to study structure-function relationship of dystrophin
info:eu-repo/grantAgreement/EC/H2020/658560/EU
Investigador responsável
European Commission
Concluído
2014/05 - 2017/10 Defining the role of impaired Hedgehog signaling in Duchenne muscular dystrophy
Investigador responsável
Nationwide Children's Hospital, Estados Unidos
Muscular Dystrophy Association
Concluído
2013/08/12 - 2017/06 (PQD6) Muscle stem cells and cancer cachexia
info:eu-repo/grantAgreement/NIH/NATIONAL CANCER INSTITUTE/1R01CA180057-01/US
Investigador
National Institutes of Health
Concluído
2014/07/05 - 2016/06 Mechanisms and efficacy of myostatin inhibition in myotubular myopathy
info:eu-repo/grantAgreement/NIH/NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES/3K08AR059750-04S1/US
Bolseiro de Cientista Convidado
National Institutes of Health
Concluído
2012/02 - 2013/01 Analysis of protein interactions mediated by micro-dystrophin in the mdx heart
Investigador responsável
Parent Project Muscular Dystrophy
Concluído
2011/08 - 2012/07 Analysis of protein interactions mediated by micro-dystrophin in the mdx heart
Investigador responsável
Parent Project Muscular Dystrophy
Concluído
2009/12 - 2011/11 Muscle Stem Cells as a New Therapeutic Target in Pancreatic Cancer Cachexia
Investigador responsável
Nationwide Children's Hospital

The Ohio State University Center for Clinical and Translational Science
Concluído
Produções

Publicações

Artigo em revista
  1. Wang, Hong; Marrosu, Elena; Brayson, Daniel; Wasala, Nalinda B; Johnson, Eric K; Scott, Charlotte S; Yue, Yongping; et al. Autor correspondente: Montanaro, Federica. "Proteomic analysis identifies key differences in the cardiac interactomes of dystrophin and micro-dystrophin". Human Molecular Genetics 30 14 (2021): 1321-1336. http://dx.doi.org/10.1093/hmg/ddab133.
    Acesso aberto • Publicado • 10.1093/hmg/ddab133
  2. Omairi S; Hau KL; Collins-Hooper H; Scott C; Vaiyapuri S; Torelli S; Montanaro F; Matsakas A; Patel K. "Regulation of the dystrophin-associated glycoprotein complex composition by the metabolic properties of muscle fibres.". Scientific Reports 9 1 (2019): http://europepmc.org/abstract/med/30808964.
    Publicado • 10.1038/s41598-019-39532-4
  3. Wasala, Nalinda B.; Shin, Jin-Hong; Lai, Yi; Yue, Yongping; Montanaro, Federica; Duan, Dongsheng. "Cardiac-Specific Expression of ¿H2-R15 Mini-Dystrophin Normalized All Electrocardiogram Abnormalities and the End-Diastolic Volume in a 23-Month-Old Mouse Model of Duchenne Dilated Cardiomyopathy". Human Gene Therapy 29 7 (2018): 737-748. http://dx.doi.org/10.1089/hum.2017.144.
    10.1089/hum.2017.144
  4. Omairi, Saleh; Hau, Kwan-Leong; Collin-Hooper, Henry; Montanaro, Federica; Goyenvalle, Aurelie; Garcia, Luis; Patel, Ketan. "Link between MHC Fiber Type and Restoration of Dystrophin Expression and Key Components of the DAPC by Tricyclo-DNA-Mediated Exon Skipping". Molecular Therapy - Nucleic Acids 9 (2017): 409-418. http://dx.doi.org/10.1016/j.omtn.2017.10.014.
    Publicado • 10.1016/j.omtn.2017.10.014
  5. Hallak, Louay K.; Berger, Kelly; Kaspar, Rita; Kwilas, Anna R.; Montanaro, Federica; Peeples, Mark E.. "Efficient method for site-directed mutagenesis in large plasmids without subcloning". PLOS ONE 12 6 (2017): e0177788. http://dx.doi.org/10.1371/journal.pone.0177788.
    Publicado • 10.1371/journal.pone.0177788
  6. Kalra, Spandan; Montanaro, Federica; Denning, Chris. "Can Human Pluripotent Stem Cell-Derived Cardiomyocytes Advance Understanding of Muscular Dystrophies?". Journal of Neuromuscular Diseases 3 3 (2016): 309-332. http://dx.doi.org/10.3233/jnd-150133.
    Publicado • 10.3233/jnd-150133
  7. Vulin, Adeline; Wein, Nicolas; Strandjord, Dana M.; Johnson, Eric K.; Findlay, Andrew R.; Maiti, Baijayanta; Howard, Michael T.; et al. "The ZZ Domain of Dystrophin in DMD: Making Sense of Missense Mutations". Human Mutation 35 2 (2013): 257-264. http://dx.doi.org/10.1002/humu.22479.
    Publicado • 10.1002/humu.22479
  8. He, Wei A.; Berardi, Emanuele; Cardillo, Veronica M.; Acharyya, Swarnali; Aulino, Paola; Thomas-Ahner, Jennifer; Wang, Jingxin; et al. "NF-kB-mediated Pax7 dysregulation in the muscle microenvironment promotes cancer cachexia". Journal of Clinical Investigation 123 11 (2013): 4821-4835. http://dx.doi.org/10.1172/jci68523.
    Publicado • 10.1172/jci68523
  9. Johnson, Eric K.; Li, Bin; Yoon, Jung Hae; Flanigan, Kevin M.; Martin, Paul T.; Ervasti, James; Montanaro, Federica. "Identification of New Dystroglycan Complexes in Skeletal Muscle". PLoS ONE 8 8 (2013): e73224. http://dx.doi.org/10.1371/journal.pone.0073224.
    Publicado • 10.1371/journal.pone.0073224
  10. Penton, Christopher M.; Thomas-Ahner, Jennifer M.; Johnson, Eric K.; McAllister, Cynthia; Montanaro, Federica. "Muscle Side Population Cells from Dystrophic or Injured Muscle Adopt a Fibro-Adipogenic Fate". PLoS ONE 8 1 (2013): e54553. http://dx.doi.org/10.1371/journal.pone.0054553.
    Publicado • 10.1371/journal.pone.0054553
  11. Johnson, Eric K.; Zhang, Liwen; Adams, Marvin E.; Phillips, Alistair; Freitas, Michael A.; Froehner, Stanley C.; Green-Church, Kari B.; Montanaro, Federica. "Proteomic Analysis Reveals New Cardiac-Specific Dystrophin-Associated Proteins". PLoS ONE 7 8 (2012): e43515. http://dx.doi.org/10.1371/journal.pone.0043515.
    Publicado • 10.1371/journal.pone.0043515
  12. Yoon, Jung Hae; Johnson, Eric; Xu, Rui; Martin, Laura T.; Martin, Paul T.; Montanaro, Federica. "Comparative Proteomic Profiling of Dystroglycan-Associated Proteins in Wild Type, mdx and Galgt2 Transgenic Mouse Skeletal Muscle". Journal of Proteome Research 11 9 (2012): 4413-4424. http://dx.doi.org/10.1021/pr300328r.
    Publicado • 10.1021/pr300328r
  13. Beastrom, Nicholas; Lu, Haiyan; Macke, Allison; Canan, Benjamin D.; Johnson, Eric K.; Penton, Christopher M.; Kaspar, Brian K.; et al. "Mdx5cv Mice Manifest More Severe Muscle Dysfunction and Diaphragm Force Deficits than mdx Mice". The American Journal of Pathology 179 5 (2011): 2464-2474. http://dx.doi.org/10.1016/j.ajpath.2011.07.009.
    Publicado • 10.1016/j.ajpath.2011.07.009
  14. Leblanc, Elisabeth; Trensz, Frédéric; Haroun, Sonia; Drouin, Geneviève; Bergeron, Éric; Penton, Christopher M; Montanaro, Federica; et al. "BMP-9-induced muscle heterotopic ossification requires changes to the skeletal muscle microenvironment". Journal of Bone and Mineral Research 26 6 (2011): 1166-1177. http://dx.doi.org/10.1002/jbmr.311.
    Publicado • 10.1002/jbmr.311
  15. Alexander, Matthew S.; Kawahara, Genri; Kho, Alvin T.; Howell, Melanie H.; Pusack, Timothy J.; Myers, Jennifer A.; Montanaro, Federica; et al. "Isolation and transcriptome analysis of adult zebrafish cells enriched for skeletal muscle progenitors". Muscle & Nerve 43 5 (2011): 741-750. http://dx.doi.org/10.1002/mus.21972.
    Publicado • 10.1002/mus.21972
  16. Montanaro, Federica; Allen, Hugh D.; Mendell, Jerry R.; Kaspar, Rita Wen; Flanigan, Kevin M.; Kissel, John T.; Pestronk, Alan; et al. "Response to Letter by Yilmaz et al Regarding Article, “Analysis of Dystrophin Deletion Mutations Predicts Age of Cardiomyopathy Onset in Becker Muscular Dystrophy”". Circulation: Cardiovascular Genetics 3 2 (2010): http://dx.doi.org/10.1161/circgenetics.110.945691.
    10.1161/circgenetics.110.945691
  17. Kaspar, Rita Wen; Allen, Hugh D.; Ray, Will C.; Alvarez, Carlos E.; Kissel, John T.; Pestronk, Alan; Weiss, Robert B.; et al. "Analysis of Dystrophin Deletion Mutations Predicts Age of Cardiomyopathy Onset in Becker Muscular Dystrophy". Circulation: Cardiovascular Genetics 2 6 (2009): 544-551. http://dx.doi.org/10.1161/circgenetics.109.867242.
    Publicado • 10.1161/circgenetics.109.867242
  18. Kaspar, Rita Wen; Allen, Hugh D.; Montanaro, Federica. "Current understanding and management of dilated cardiomyopathy in Duchenne and Becker muscular dystrophy". Journal of the American Academy of Nurse Practitioners 21 5 (2009): 241-249. http://dx.doi.org/10.1111/j.1745-7599.2009.00404.x.
    Publicado • 10.1111/j.1745-7599.2009.00404.x
  19. GUYON, J; MOSLEY, A; JUN, S; MONTANARO, F; STEFFEN, L; ZHOU, Y; NIGRO, V; ZON, L; KUNKEL, L. "Delta-Sarcoglycan is required for early zebrafish muscle organization". Experimental Cell Research 304 1 (2005): 105-115. http://dx.doi.org/10.1016/j.yexcr.2004.10.032.
    Publicado • 10.1016/j.yexcr.2004.10.032
  20. Montanaro, Federica; Liadaki, Kalliopi; Schienda, Jaclyn; Flint, Alan; Gussoni, Emanuela; Kunkel, Louis M.. "Demystifying SP cell purification: viability, yield, and phenotype are defined by isolation parameters". Experimental Cell Research 298 1 (2004): 144-154. http://dx.doi.org/10.1016/j.yexcr.2004.04.010.
    Publicado • 10.1016/j.yexcr.2004.04.010
  21. Tomczak, Kinga K.; Marinescu, Voichita D.; Ramoni, Marco F.; Sanoudou, Despina; Montanaro, Federica; Han, Mei; Kunkel, Louis M.; Kohane, Isaac S.; Beggs, Alan H.. "Expression profiling and identification of novel genes involved in myogenic differentiation". The FASEB Journal 18 2 (2003): 403-405. http://dx.doi.org/10.1096/fj.03-0568fje.
    Publicado • 10.1096/fj.03-0568fje
  22. Montanaro, F.; Liadaki, K.; Volinski, J.; Flint, A.; Kunkel, L. M.. "Skeletal muscle engraftment potential of adult mouse skin side population cells". Proceedings of the National Academy of Sciences 100 16 (2003): 9336-9341. http://dx.doi.org/10.1073/pnas.1133179100.
    Publicado • 10.1073/pnas.1133179100
  23. Montanaro, F.; Carbonetto, S.. "Targeting Dystroglycan in the Brain". Neuron 37 2 (2003): 193-196. http://dx.doi.org/10.1016/s0896-6273(03)00032-1.
    Publicado • 10.1016/s0896-6273(03)00032-1
  24. Montanaro F; Carbonetto S. "Developmental biology of synapse formation". Encyclopedia of Life Sciences (2000): http://www.els.net/..
    Publicado
  25. Montanaro, Federica; Lindenbaum, Michael; Carbonetto, Salvatore. "Alpha-Dystroglycan Is a Laminin Receptor Involved in Extracellular Matrix Assembly on Myotubes and Muscle Cell Viability". Journal of Cell Biology 145 6 (1999): 1325-1340. http://dx.doi.org/10.1083/jcb.145.6.1325.
    Publicado • 10.1083/jcb.145.6.1325
  26. Jacobson, Christian; Montanaro, Federica; Lindenbaum, Michael; Carbonetto, Salvatore; Ferns, Michael. "Alpha-Dystroglycan Functions in Acetylcholine Receptor Aggregation But Is Not a Coreceptor for Agrin-MuSK Signaling". The Journal of Neuroscience 18 16 (1998): 6340-6348. http://dx.doi.org/10.1523/jneurosci.18-16-06340.1998.
    Publicado • 10.1523/jneurosci.18-16-06340.1998
  27. Montanaro, Federica; Gee, Stephen H.; Jacobson, Christian; Lindenbaum, Michael H.; Froehner, Stanley C.; Carbonetto, Salvatore. "Laminin and alpha-Dystroglycan Mediate Acetylcholine Receptor Aggregation via a MuSK-Independent Pathway". The Journal of Neuroscience 18 4 (1998): 1250-1260. http://dx.doi.org/10.1523/jneurosci.18-04-01250.1998.
    Publicado • 10.1523/jneurosci.18-04-01250.1998
  28. Montanaro, F.; Carbonetto, S.; Campbell, K. P.; Lindenbaum, M.. "Dystroglycan expression in the wild type and mdx mouse neural retina: Synaptic colocalization with dystrophin, dystrophin-related protein but not laminin". Journal of Neuroscience Research 42 4 (1995): 528-538. http://dx.doi.org/10.1002/jnr.490420411.
    Publicado • 10.1002/jnr.490420411
  29. Gee, Stephen H.; Montanaro, Federica; Lindenbaum, Michael H.; Carbonetto, Salvatore. "Dystroglycan-alpha, a dystrophin-associated glycoprotein, is a functional agrin receptor". Cell 77 5 (1994): 675-686. http://dx.doi.org/10.1016/0092-8674(94)90052-3.
    Publicado • 10.1016/0092-8674(94)90052-3
Capítulo de livro
  1. Montanaro, Federica; Martin, Paul T.. "Defective Glycosylation of Dystroglycan in Muscular Dystrophy and Cancer". In Post-Translational Modifications in Health and Disease, editado por Cecilio Vidal Moreno, 119-143. Springer New York, 2011.
    Publicado • 10.1007/978-1-4419-6382-6_6
  2. Montanaro F; Liadaki K. "Cellular-mediated delivery: the intersection between regenerative medicineand genetic therapy". In Duchenne muscular dystrophy: Advances in therapeutics, editado por Rando T. and Chamberlain J., 295-318. New York, Estados Unidos: Taylor and Francis Group, 2006.
    Publicado
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2021/02 Micro-dystrophin gene therapy to treat cardiomyopathy in Duchenne muscular dystrophy Research Seminar Series
University of Surrey (Surrey, Reino Unido)
2020/01 Seminar- Gene therapy in Duchenne muscular dystrophy cardiomyopathy Cambridge cardiovascular symposium
Cambridge University (Cambridge, Reino Unido)
2019/12 Conference- Dystrophin and related molecules in heart disease The 7th International Cardiovascular Genomic Medicine Conference. ‘Clinical Cardiology in the Genome Era
(York, Reino Unido)
2019/07 Seminar- Gene therapy to treat heart disease in Duchenne Muscular Dystrophy Developmental Neurosciences Seminar
UCL Great Ormond Street Institute of Child Health (London, Reino Unido)
2018/05 Conference- Cardiomyopathy in Dystrophinopathies: new discoveries University College London Cardiovascular Symposium
(London, Reino Unido)
2018/05 Seminar- Cardiomyopathy and gene therapy in Duchenne Muscular Dystrophy Genomics and Child Health Research Seminar Series
Barts and The London School of Medicine and Dentistry (London, Reino Unido)
2017/02 Seminar- Rediscovering dystrophin: structure/function relationships in skeletal and cardiac muscles Medical Research Council Center Distinguished Scientist Seminar
(London, Reino Unido)
2016/11 Conference- Hedgehog signaling and Duchenne muscular dystrophy 18th London Myology Forum
(London, Reino Unido)
2015/09 Conference- Activation of Hedgehog signaling halts disease progression in muscular dystrophy: differential impact on respiratory and limb muscles EMBO Workshop on Molecular mechanisms of muscle growth and wasting in health and disease
(Ascona, Suiça)
2015/01 Seminar- Proteomics: re-thinking current paradigms of rare genetic diseases
University of Newcastle upon Tyne, International Centre for Life (Newcastle, Reino Unido)
2015/01 Seminar- What stem cells and proteomics teach us about muscle disease
University of Nottingham (Nottingham, Reino Unido)
2014/12 Seminar- What stem cells teach us about muscle disease Ohio State University College of Education and Human Ecology Special Seminar
(Columbus, Estados Unidos)
2014/07 Conference- Hedgehog: a new pathway involved in muscle regeneration and fibrosis in Duchenne muscular dystrophy FASEB Meeting. Skeletal Muscle Satellite and Stem Cells.
(Colorado, Estados Unidos)
2014/07 Seminar- Using stem cells and proteomics to study disease mechanisms in Duchenne Muscular Dystrophy Medical Research Council Center Distinguished Scientist Seminar
University College London (London, Reino Unido)
2014/02 Seminar- Duchenne Muscular Dystrophy: using stem cells and proteomics to understand disease mechanisms
Otterbein University (Columbus, Estados Unidos)
2013/10 Conference- Identification of novel dystroglycan-associated glycoprotein complexes in skeletal muscle World Muscle Society Meeting
(California, Estados Unidos)
2013/09 Conference- Identification of a new pathway involved in muscle regeneration and fibrosis in muscular dystrophy EMBO Workshop on Molecular mechanisms of muscle growth and wasting in health and disease
(Ascona, Suiça)
2013/07 Seminar- Dystrophin, dystrophin-associated proteins, and new therapeutic approaches for Duchenne muscular dystrophy The Research Institute at Nationwide Children’s Hospital Bench to Outcomes Seminar Series
(Columbus, Estados Unidos)
2012/10 Conference- New model of dystrophin interactions in striated muscles Wellstone Centers Network Meeting
(Boston, Estados Unidos)
2012/09 Seminar- New disease mechanisms in Duchenne muscular dystrophy The Child Health Research Center Speaker Series
Nationwide Children's Hospital/Ohio State University (Columbus, Estados Unidos)
2011/07/21 Seminar- Duchenne Muscular Dystrophy: New Models of Disease Mechanisms
IBMC Institute (Porto, Portugal)
2011/04 Seminar- Mechanisms of muscle wasting in cancer cachexia OSUMC and NCH joint research day
(Columbus, Estados Unidos)
2011/01 Conference- Becker Cardiomyopathy Heart in Duchenne Muscular Dystrophy Meeting
Nationwide Children’s Hospital (Columbus, Estados Unidos)
2010/05/05 Seminar- Dystrophin and cardiomyo Montreal General Hospital Seminar series
McGill University (Montreal, Canadá)
2008/12 Conference- Genotype Analysis Predicts Dilated Cardiomyopathy in Becker Muscular Dystrophy United Dystrophinopathy Project
(Chicago, Estados Unidos)
2007/06 Conference- Gene Expression Data: Cracking the Code 3rd Seattle Muscular Dystrophy Conference
(Washington, Estados Unidos)
2005/09 Seminar- Identification of new pathways in muscular dystrophy and advances in cell-based therapy The Child Health Research Center Speaker Series
Nationwide Children's Hospital/Ohio State University (Columbus, Estados Unidos)

Orientação

Título / Tema
Papel desempenhado
Curso (Tipo)
Instituição / Organização
2019 - Atual Post-doctoral Fellow academic supervision
Orientador de Betty Kao
2019 - Atual Post-doctoral Fellow academic supervision
Orientador de Daniel Brayson
2017 - Atual Doctoral Student academic supervision
Orientador de Elena Marrosu
University College London- Great Ormond Street Institute of Child Health - Dubowitz Neuromuscular Unit,, Reino Unido
2015 - 2015 Undergraduate student academic supervision
Orientador de Mac Samkoe
biology program (Licenciatura/Bacharelato)
The Ohio State University, Estados Unidos
2015 - 2015 Undergraduate student academic supervision
Orientador de Josh Walum
mathematics program (Licenciatura/Bacharelato)
The Ohio State University, Estados Unidos
2015 - 2015 High School Student academic supervision
Orientador de Lili Silayeva
Harvard Medical School, Estados Unidos
2013 - 2015 Undergraduate student academic supervision
Orientador de Samantha Devenport
biology program (Licenciatura/Bacharelato)
The Ohio State University, Estados Unidos
2013 - 2014 Post-doctoral Fellow academic supervision
Orientador de Hong Wang M.D
Shengjing Hospital of China Medical University, China
2013 - 2013 Undergraduate student academic supervision
Orientador de Madison Caja
The Ohio State University, Estados Unidos
2012 - 2013 Undergraduate student academic supervision
Orientador de Nelson Salgado
Discovery PREP NIH Program (Licenciatura/Bacharelato)
The Research Institute at Nationwide Children’s Hospital, Estados Unidos
2009 - 2013 Doctoral Student academic Supervision
Orientador de Christopher Penton
The Ohio State University College of Medicine, Estados Unidos
2012 - 2012 High School Student academic supervision
Orientador de Eva Partida
Summer Scientist Program (Iniciação científica)
The Research Institute at Nationwide Children’s Hospital, Estados Unidos
2012 - 2012 Medical Student academic supervision
Orientador de Sarah Tuthill
Roessler Fellowship Program (Outra)
The Ohio State University College of Medicine, Estados Unidos
2008 - 2012 Doctoral Student academic supervision
Orientador de Eric Johnson
Biochemistry Program (OSBP) (Doutoramento)
The Ohio State University, Estados Unidos
2011 - 2011 High School Students academic supervision
Orientador de Eva Partida
Summer Scientist Program (Iniciação científica)
The Research Institute at Nationwide Children’s Hospital, Estados Unidos
2007 - 2009 Doctoral Student academic supervision
Coorientador de Rita Wen-Kaspar
The Ohio State University College of Nursing, Estados Unidos
2007 - 2009 Post-doctoral Fellow academic supervision
Orientador de Jennifer Thomas-Ahner
2006 - 2009 Master student academic supervision
Orientador de Jesse Gibbons
The Ohio State University, Estados Unidos
2008 - 2008 Medical Student academic supervision
Orientador de Erin Horning
Roessler Fellowship Program (Outra)
The Ohio State University College of Medicine, Estados Unidos
2006 - 2006 Medical Student academic supervision
Orientador de Haven Garber
Roessler Fellowship Program (Outra)
The Ohio State University College of Medicine, Estados Unidos

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação)
Instituição / Organização
2018 - Atual Job interview preparation- Together with Prof. Jennifer Morgan and Dr. Silvia Torelli, guidance and advice are provided to those who ask for it for preparation for job interviews at the lecturer level and above. Two candidates have taken advantage of this support and have both successfully obtained lecturer positions. (2018)
Outro
2017 - Atual Presentation skills- I initiated and implemented a system within the Dubowitz Neuromuscular Cantre to teach effective presentation skills to scientists in our group. This takes the form of group feedback and discussion on the quality and clarity of presentations given at group lab meetings, and mandatory rehearsals of any oral presentations to be given by members of the DNC at any event. (2017)
Outro (Membro da Comissão Organizadora)
University College London- Institute of Child Health- Dubowitz Neuromuscular Unit, Reino Unido
2017 - Atual Grant brainstorming sessions- I initiated and implemented within the Dubowitz Neuromuscular Center (although this is now expanding to include the ION and some collaborator groups) regular sessions where grant applications that are in preparation or have not been awarded are reviewed and constructive criticism is provided in a friendly open environment. Although participation is voluntary for junior members, attendance and participation has been high. More junior people have written and submitted grant applications, with a high rate of success. (2017)
Encontro (Membro da Comissão Organizadora)
University College London- Institute of Child Health- Dubowitz Neuromuscular Unit, Reino Unido
2017 - Atual I co-initiated this program with Prof. Jennifer Morgan and Dr. Silvia Torelli to support career development for graduate student, post-doctoral fellows and clinical research fellows. We have seen dramatic improvements in scientific presentation skills and in grant/fellowship writing skills. (2017)
Outro (Coorganizador)
Dubowitz Neuromuscular Centre, Reino Unido
2012/09 - Atual Muscle Stem Cell Isolation Workshop- I organized this hands-on Workshop on the prospective isolation of muscle stem cell by flow cytometry. This workshop was extremely popular and was later expanded into two separate workshops on cell isolation and flow cytometry. (2012/09)
Oficina (workshop) (Membro da Comissão Organizadora)
2016 - 2017 Personalized Medicine Early Career Network Committee Member- This committee organizes networking and training events for individuals at UCL who are in the early stages of their career in fields associated with personalized medicine. The goal is to facilitate their career development. (2016 - 2017)
Oficina (workshop)
University College London- Great Ormond Street Institute of Child Health , Reino Unido
2013/08 - 2015 Flow Cytometry Workshop- I organized this hands-on Workshop on Flow Cytometry techniques commonly used to study muscle cells for selected participants of the international myology training course. This has been one of the most popular workshops offered in the course with two fully booked 4 hour sessions in one week. (2013/08 - 2015)
Oficina (workshop) (Membro da Comissão Organizadora)
2012 - 2014 Organizer of the Research in Progress meetings for the Center for Gene Therapy- This is a monthly hour long meeting where post-doctoral fellows and students from each of the eight independent research labs of our Center present their most current research in a formal 35 min presentation followed by discussion. These meetings allow for group review of projects and group guidance/mentoring of trainees. (2012 - 2014)
Encontro (Membro da Comissão Organizadora)
The Research Institute at Nationwide Children’s Hospital, Estados Unidos
2011 - 2014 Faculty Forum- I am one of the creators of this committee that provides an essential forum for faculty to discuss faculty-related matters and seeks to find practical, actionable solutions to problems in close collaboration with administration. We have tackled issues such as the development of junior faculty mentoring programs, increasing the engagement of our trainees and promoting their education, and implementing organizational changes that increase our competitiveness for NIH grants and career awards. (2011 - 2014)
Encontro (Membro da Comissão Organizadora)
The Research Institute at Nationwide Children’s Hospital, Estados Unidos
2009/04 - 2010/04 Member of Organizing Committee-This committee organises the 2- day annual research retreat of the entire research institute. I have served on this committee for two years and I have contributed significant changes to how the retreat was formatted. In particular, I instituted travel awards for the best presentations to allow trainees to present their work at a national scientific meeting, and brought in external judges to increase the visibility of our Institute’s research and promote new collaborations. (2009/04 - 2010/04)
Outro (Membro da Comissão Organizadora)
Nationwide Children’s Hospital Research Institute Research retreat , Estados Unidos

Participação em evento

Descrição da atividade
Tipo de evento
Nome do evento
Instituição / Organização
2019/12 - 2019/12 Panel presenter and Q&A session participant
Conferência
MDUK National Conference, London, UK
2018/07 - 2018/07 Y10 Work shadowing programme
Outro
Queens’ School, Reino Unido
2018 - 2018 Women in Leadership Workshop
Oficina (workshop)
Women in Leadership
University College London- Great Ormond Street Institute of Child Health , Reino Unido
2018 - 2018 The strategic academic. UCL professional development workshop.
Oficina (workshop)
The strategic academic.
University College London- Great Ormond Street Institute of Child Health , Reino Unido
2018 - 2018 Influencing, negotiating, networking. UCL professional development workshop.
Oficina (workshop)
Influencing, negotiating, networking
University College London- Great Ormond Street Institute of Child Health , Reino Unido
2017 - 2017 Leadership for partnerships and collaborations. UCL professional development workshop.
Oficina (workshop)
Leadership for partnerships and collaborations
University College London- Great Ormond Street Institute of Child Health , Reino Unido
2017 - 2017 More time for successful research. UCL professional development workshop.
Oficina (workshop)
More time for successful research
University College London- Great Ormond Street Institute of Child Health , Reino Unido
2017 - 2017 Appraisal workshop. UCL mandatory training for supervisors performing employee appraisals
Oficina (workshop)
Appraisal workshop
University College London- Great Ormond Street Institute of Child Health , Reino Unido
2016/10 - 2016/10 GOSH BRC Open Day- This is a yearly free public event, which was aimed at raising awareness of child health research. Over 80 members of staff and students from across ICH and GOSH were involved in the planning and running of the event and on the day the event was attended by over 300 members of the public. I participated in “Superman’s Muscle Lab” section. I showed muscle histology samples and live muscle cultures to participants using microscopes and explained features used to diagnose muscle diseases.
Outro
GOSH BRC Open Day
2016 - 2016 Unconscious bias training. UCL mandatory training for serving and chairing interview panels
Oficina (workshop)
Unconscious bias training
University College London- Great Ormond Street Institute of Child Health , Reino Unido
2015 - 2015 Home Office personal licence (Modules 1-4 training).
Outro
2003 - 2003 BD FACSVantage certified operator: Flow cytometry/ Cell sorting, Beckton Dickinson, USA
Outro
2001 - 2001 The skin and its cells workshop, Massachusetts General Hospital, USA
Oficina (workshop)
The skin and its cells workshop
Massachusetts General Hospital, Estados Unidos
1997 - 1997 Microscopy and imaging techniques for neuroscience research, Canadian Networks of Centers of Excellence, Neuroscience network training program, University of Toronto, Canada
Oficina (workshop)
Neuroscience network training program
1996 - 1996 Tissue culture course in neurobiology, Canadian Networks of Centers of Excellence, Neuroscience network training program, University of Saskatchewan, Canada
Oficina (workshop)
Neuroscience network training program

Arbitragem científica em revista

Nome da revista (ISSN) Editora
2009 - 2019 Journal of Histochemistry & Cytochemistry (1551-5044) SAGE Publications
2017 - 2017 Cardiovascular Research (1755-3245) Oxford University Press
2016 - 2016 Nature Communications (2041-1723) Springer Science and Business Media LLC
2015 - 2015 PLoS Medicine (1549-1676) Public Library of Science
2015 - 2015 Journal of Neuromuscular Diseases (2214-3602) IOS Press
2015 - 2015 Brain (1460-2156) Oxford University Press
2012 - 2015 Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics (1570-9639) Elsevier
2010 - 2015 PLOS ONE (1932-6203) Public Library of Science
2014 - 2014 European Journal of Histochemistry (2038-8306) PAGEPress Publications
2014 - 2014 Circulation Cardiovascular Genetics (1942-3268) Ovid Technologies Wolters Kluwer -American Heart Association
2014 - 2014 Journal of Biomechanics (0021-9290) Elsevier
2014 - 2014 Journal of Pediatric Neurology (1875-9041) Georg Thieme Verlag KG
2014 - 2014 Neuromuscular Disorders (0960-8966) Elsevier
2014 - 2014 PROTEOMICS - CLINICAL APPLICATIONS (1862-8354) Wiley (John Wiley & Sons)
2010 - 2014 Circulation Journal (1347-4820) The Japanese Circulation Society
2013 - 2013 journal of Proteome Science and Computational Biology (2050-2273) Herbert Publications
2013 - 2013 Journal of Visualized Experiments (1940-087X) MyJoVE Corporation
2012 - 2012 Archives of Neurology (0003-9942) American Medical Association
2012 - 2012 Medicinal Research Reviews (1098-1128) Wiley (John Wiley & Sons)
2011 - 2012 Stem Cells and Development (1557-8534) Mary Ann Liebert
2010 - 2010 Biological Research For Nursing (1552-4175) SAGE Publications
2010 - 2010 Muscle & Nerve (1097-4598) Wiley (John Wiley & Sons)
2007 - 2007 Nature Medicine (1744-7933) Springer Science and Business Media LLC

Comissão de avaliação

Descrição da atividade
Tipo de assessoria
Instituição / Organização Entidade financiadora
2016 - Atual Clinical Research Adoptions Committee Member- This committee reviews and approves clinical research proposals at GOSH/ICH ensuring that clinical research is of the highest quality.
Avaliador
University College London- Great Ormond Street Institute of Child Health , Reino Unido
2019 - 2019 Grant Reviewer- The British Heart Foundation
Avaliador
2012 - 2019 Grant Reviewer- Czech Science Foundation, Czechoslovakia
Avaliador
2017 - 2017 Grant Reviewer- Association Nationale de Recherche, France
Avaliador
2014 - 2016 Grant Reviewer- Italian Telethon, Italy
Avaliador
2015 - 2015 Grant Reviewer- Action Medical Research for Children, UK
Avaliador
2014 - 2014 Grant Reviewer- Dutch Parent Project
Avaliador
2011 - 2014 Grant Reviewer- Medical Research Council, UK
Avaliador
2010 - 2013 Grant Reviewer- Muscular Dystrophy Campain, UK,
Avaliador
2012 - 2012 Grant Reviewer- BBSRC, UK
Avaliador
2012 - 2012 Grant Reviewer- Association Francaise contre les Myopaties, France
Avaliador
2011 - 2011 Grant Reviewer- Parent Project Muscular Dystrophy
Avaliador
2009 - 2009 Grant Reviewer- Wiener Wissenschafts-, Forschungs- und Technologiefonds (WWTF), Australia
Avaliador
2007 - 2007 Grant Reviewer- The Myositis Association, Ad hoc reviewer
Avaliador
The Myositis Association, Estados Unidos

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2021/03 - Atual Grant writing workshop MSc Programme in molecular aspects of cell and gene therapy (Master) University College London Institute of Neurology Queen Square Multiple Sclerosis Centre, Reino Unido
2020 - 2020 Invited Lecture: Gene therapy for Duchenne muscular dystrophy MSc Programme in molecular aspects of cell and gene therapy (Master) University College London- Great Ormond Street Institute of Child Health , Reino Unido
2019/09 - 2019/11 Invited Lecture: How to approach a grant application. Developmental Neurosciences trainee lecture series University College London- Great Ormond Street Institute of Child Health , Reino Unido
2014/11 - 2014/12 Invited Lecture. “Heart Physiology” Anatomy and Physiology Course Otterbein University, Estados Unidos
2014/11 - 2014/12 Invited Lecture. “Muscle Fibrosis” Fundamentals of Muscle Biology The Ohio State University, Estados Unidos
2012/09 - 2013/08 The Myology Training Course course is unique in North America. It is an intensive one week course that combines lectures, wet labs, and visits to the clinic. My lecture on muscle development serves as an introduction to the entire Myology Training Course by providing information on muscle development, muscle structure and muscle regeneration that is essential to our understanding of muscle diseases that manifest post-natally. Myology Training Course The Research Institute at Nationwide Children’s Hospital, Estados Unidos
2012/03 - 2012/05 The goal of this course was to introduce students to various experimental treatment approaches and to the process leading from the bench to a clinical trial. We designed the course to directly engage students by having them work in pairs to come up with a strategy to test a novel treatment approach for a disease of their choice for which no treatment is available. The strategy was presented to the entire class and was evaluated by the group for feasibility, cost, likelihood of success, and its potential for translation to a clinical setting. Advanced IBGP Seminar Course The Ohio State University College of Medicine, Estados Unidos
2011/08 - 2011/08 This is a series of lectures for undergraduate students who are interested in a career in research or medicine. The goal is for students to get an appreciation of the different paths that researchers have taken in their career to find their vocation. Young Scientist Education Series The Research Institute at Nationwide Children’s Hospital, Estados Unidos
2010/11 - 2010/12 Invited Lecture. “Using shotgun proteomics to dissect protein complexes: an example from the heart”. Oral Bioseminar Course The Ohio State University, Estados Unidos
2008/03 - 2008/05 Invited Lecture. “Cardiomyopathy in Becker and Duchenne muscular dystrophy”. ANATOMY The Ohio State University, Estados Unidos
2006/09 - 2006/11 “Viral gene therapy and stem cell therapy”- The goal of this course was to give students an in depth understanding of the uses and challenges associated with stem- and gene-based treatment approaches. We designed the course to promote student participation by engaging them in discussions with invited speakers on a variety of topics such as ethical issues, potential patient concerns for participation in clinical trials, risk versus benefit assessment. Advanced IBGP Seminar Course The Ohio State University College of Medicine, Estados Unidos

Entrevista / Programa (rádio / tv)

Programa Tema
2012/12 - 2012/12 Podcast series: “This Month in Muscular Dystrophy”, Columbus, Ohio, USA New Cardiac Dystrophin Associated Proteins
2010/09 - 2010/09 Podcast series: “This Month in Muscular Dystrophy” Cardiomyopathy in Becker Muscular Dystrophy

Membro de associação

Nome da associação Tipo de participação
2018 - Atual British Society for Cardiovascular Research
2016 - Atual MDEX consortium
2013 - Atual World Muscle Society
2012 - Atual SigmaXi
2006 - Atual Muscle group- I am one of the founding members of this very active group of clinicians and basic/translational researchers working on muscles (smooth, skeletal and cardiac) located at the Research Institute at Nationwide Children’s and the Ohio State University campuses. This group has fostered new collaborations that resulted in one major NIH T32 teaching grant, 43 NIH collaborative grants worth around $14 million, and 176 collaborative publications from 2006-2015. Partnerships with industry and parent associations have also been established. founding member
2009 - 2015 Ohio State University Biomedical Sciences Graduate Program (IBGP)
2006 - 2015 Ohio State University Biochemistry Program (OSBP)
2012 - 2014 American Heart Association
2009 - 2010 International Society for Stem Cell Research, USA.

Membro de comissão

Descrição da atividade
Tipo de participação
Instituição / Organização
2012 - 2013 Biomedical Institutional Review Board Committee Member- I reviewed and discussed protocols involving human subject biomedical research at The Ohio State University. This committee meets once a month and I was assigned 3 to 5 protocols per meeting. I have served on this committee for 2 full years.
Membro
The Ohio State University, Estados Unidos
2012 - 2013 RITAC advisory committee to develop the Institute’s strategic plan for database and information technologies to support science- As part of this committee I participated in re-designing the Institute’s strategic plan for the development of databases and information technologies capable of supporting current and future needs of researchers.
Membro
The Research Institute at Nationwide Children’s Hospital, Estados Unidos
2008 - 2012 Neha Singhal, PhD Dissertation Committee Member- Graduated: 2012. Current Position: Post-Doctoral Fellow with Dr. James Martin at Baylor College of Medicine
Membro
The Ohio State University College of Medicine, Estados Unidos
2009 - 2010 Efficiency Task Force Aim: Review services provided by the Research Institute, identify areas that require updating or restructuring and make recommendations to leadership to increase efficiency.
Membro
The Research Institute at Nationwide Children’s Hospital, Estados Unidos
2009 - 2009 Mohosin Sarkar, Doctoral Student (Graduate School Representative for Final Dissertation Defense)
Outro
The Ohio State University, Estados Unidos
2008 - 2009 Alena Jaime-Ramirez, PhD Dissertation Committee Member
Membro
The Ohio State University, Estados Unidos
2008 - 2009 Matthew Sobo, PhD Dissertation Committee Member
Membro
The Ohio State University College of Medicine, Estados Unidos
2007 - 2007 Scott Kagan, Doctoral Student (Graduate School Representative for Final Dissertation Defense)
Outro
The Ohio State University, Estados Unidos

Outro júri / avaliação

Descrição da atividade Instituição / Organização
2006 - 2015 Head of microscopy needs for the Center for Gene Therapy- I made decisions regarding imaging needs for the Center, including personnel training and purchases of equipment and software. The Research Institute at Nationwide Children’s Hospital, Estados Unidos
2005 - 2014 Judge for Poster and Oral presentations at The Research Institute at Nationwide Children’s Hospital research Day, The Ohio State University Medical Center Research Day, The Denman Undergraduate Forum, and The Ohio State University Graduate Program Research Day.

Tutoria

Tópico Nome do aluno
2018 - 2018 Student Won Awards Elena Marrosu
2014 - 2014 Student Won Awards Samantha Devenport
2012 - 2013 Student Won Awards Nelson Salgado
2011/07 - 2012/06 Student Won Awards Eric Johnson
2012 - 2012 Invited oral presentations given by my students Eric K. Johnson
2012 - 2012 Student Won Awards Eric Johnson
2012 - 2012 Student Won Awards Christopher Penton
2012 - 2012 Student Won Awards Sarah Tuthill
2009/07 - 2011/06 Student Won Awards Eric Johnson
2007/09 - 2009/09 Student Won Awards Rita Wen-Kaspar
2009 - 2009 Invited oral presentations given by my students Eric K. Johnson
2009 - 2009 Invited oral presentations given by my students Rita Wen-Kaspar
2008 - 2008 Invited oral presentations given by my students Rita Wen-Kaspar
2008 - 2008 Student Won Awards Erin Horning
2007 - 2007 Invited oral presentations given by my students Rita Wen-Kaspar
2006 - 2006 Student Won Awards Haven Garber
Distinções

Prémio

2015 Marie Sklodowska-Curie Re-Integration Individual Fellowship Award
2013 Elsevier Award
World Muscle Society Meeting, Estados Unidos
2000 Gordon A. Maclachlan Prize awarded for PhD thesis work in Biological and Health Sciences
McGill University Department of Biology, Canadá

Outra distinção

1999 Howard Hughes Medical Institute Post-Doctoral Fellowship
Harvard Medical School, Laboratory of Dr. Louis Kunkel, Estados Unidos
1999 Dean's Honor List, Ph.D.
McGill University Department of Biology, Canadá
1994 Canadian Network of Excellence graduate Training Fellowship
Canadian Network of Centers of Excellence. McGill University, Canadá
1991 Distinction, B.Sc. degree. Department of Biology
McGill University Department of Biology, Canadá