???global.info.a_carregar???
Ana Rita Grosso gathered a Biology degree (FCUL, 2002), followed by a MSc in Bioinformatics (FCUL-IGC, 2006). Her multi-omics expertise in biomedical research was accomplished by gathering a PhD in Biomedical Sciences, under supervision of Simon Tavaré (Cambridge Univ., UK) and Maria Carmo-Fonseca (IMM/FMUL). Her PhD research unveiled the existence of splicing-factors expression signatures responsible by the tissue-specific regulation of alternative splicing. After obtaining the PhD in 2010, she did a first PostDoc with Maria Carmo-Fonseca (IMM/FMUL), followed by a second PostDoc with Sergio de Almeida (IMM/FMUL). Her PostDoc research disclosed new mechanisms of splicing and transcription dynamics. Since 2014, Ana Rita has started her own research line where she identified chromatin alterations that interfere with transcriptional fidelity in cancer. ____________________________________________________________________________________________________________________________________________ In 2018, Ana Rita Grosso moved to UCIBIO/FCT-NOVA to foster her scientific independence and consolidate her research group. Since then she obtained 1 Individual Salary Grant and 1 Project Grant, with which she could establish her current research group, composed of: 1 Senior Researcher, 2 PostDocs, 2 PhD-students, 1 junior Bioinformatician and 1 MSc Student. In parallel, she has also stablished collaborations with different research groups to decipher transcriptomic/epigenomic alterations underlying a wide range of diseases. Her main mission is to decipher pathological conditions using multi-omics approaches, identifying molecular events to be further used as biomarkers and therapeutic targets. ____________________________________________________________________________________________________________________________________________ Additionally, Ana Rita Grosso has been teaching specialized MSc courses in Genomics and Computational Biology fields, namely: ¿Computational Biology in Biomedicine¿ for the MSc in Bioinformatics and Computational Biology from (FCUL, 2012-2015); ¿Bioinformatics¿ for the MSc in Oncobiology (FMUL, 2014-2016); ¿Molecular Genomics and Evolution¿ and ¿Bioinformatics in Biomedicine¿ for the MSc in Molecular Genetics and Biomedicine (FCT-NOVA, 2018-onwards). ____________________________________________________________________________________________________________________________________________ To date, Ana Rita Grosso published 39 papers (1467 citations, h-index 19, avg-citations/paper 37.6). Also, she won in highly competitive schemes: 4 Salary Grants (PhD and PostDoc Fellowships, 2 Research Contracts); 6 Projects Grants (2 as PI, 1 as Co-PI and 3 as Researcher Core CV) as well as 2 Pfizer Awards for Basic Research. ____________________________________________________________________________________________________________________________________________
Identificação

Identificação pessoal

Nome completo
Ana Rita Grosso

Nomes de citação

  • Grosso, Ana Rita

Identificadores de autor

Ciência ID
3D18-571E-133A
ORCID iD
0000-0001-6974-4209
Researcher Id
I-6656-2013
Scopus Author Id
26639262500

Endereços de correio eletrónico

  • argrosso@fct.unl.pt (Profissional)

Moradas

  • Faculdade de Ciências e Tecnologia - Universidade Nova de Lisboa, Campus de Caparica, 2829-516, Caparica, Almada, Portugal (Profissional)

Websites

  • https://comics.dcv.fct.unl.pt (Profissional)

Domínios de atuação

  • Ciências Exatas - Ciências da Computação e da Informação - Bioinformática
  • Ciências Naturais - Ciências Biológicas - Biologia Celular
  • Ciências Médicas e da Saúde - Medicina Básica

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português (Idioma materno)
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Formação
Grau Classificação
2010
Concluído
Ciências Biomedicas (Doutoramento)
Universidade de Lisboa Faculdade de Medicina, Portugal
"New insights into alternative splicing using microarray technology " (TESE/DISSERTAÇÃO)
Distinção e Louvor por unanimidade
2006
Concluído
Bioinformatica (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
"Statistical Methodologies for the Analysis of DNA Microarray Data" (TESE/DISSERTAÇÃO)
Muito Bom
2002
Concluído
Biologia (Licenciatura)
Universidade de Lisboa Faculdade de Ciências, Portugal
"“Estudo Filogenético de Populações Europeias de Columba palumbus (Pombo-Torcaz), Recorrendo à Análise de DNA Mitocondrial”" (TESE/DISSERTAÇÃO)
15
Percurso profissional

Ciência

2018/01/01 - Atual Investigador Auxiliar (carreira) (Investigação)
Empregador
REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
2015/01/01 - 2017/12/31 Investigador Auxiliar (carreira) (Investigação)
Empregador
Instituto de Medicina Molecular, Portugal
2010/03/01 - 2014/12/31 Pós-doutorado (Investigação)
Empregador
Instituto de Medicina Molecular, Portugal
2002/10/01 - 2005/12/31 Investigador (Investigação)
Empregador
Universidade de Lisboa Faculdade de Ciências, Portugal
Projetos

Bolsa

Designação Financiadores
2018 - 2021/09/30 Targeting Intra-Tumor heterogeneity as a promising therapeutic strategy for cancer
PTDC/MED-ONC/28660/2017
Investigador responsável
REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
Fundação para a Ciência e a Tecnologia, I.P.
2018 - 2021/07/31 A critical role for DNA damage in transcription that impacts cell differentiation and tumor development
PTDC/BIA-MOL/30438/2017
Investigador
Instituto de Medicina Molecular, Portugal
Fundação para a Ciência e a Tecnologia, I.P.
2015 - 2019/12/01 Decoding pseudogene transcriptional regulation during cell differentiation
IF/00510/2014
Investigador responsável
Instituto de Medicina Molecular, Portugal
Fundação para a Ciência e a Tecnologia, I.P.
2016 - 2018/12 Novel tumorigenic mechanisms of aberrant epigenetic regulation in clear cell renal cell carcinoma
Provided by PTCRIS: 138597
Fundação para a Ciência e a Tecnologia, I.P.
2015 - 2018/11 Long non-coding RNAs as new diagnostic biomarkers for African Sleeping sickness.
Provided by PTCRIS: 145744
Fundação para a Ciência e a Tecnologia, I.P.
2013 - 2015/11 SETD2 mediates a novel tumor suppressor mechanism that is misregulated in clear cell renal carcinoma
Provided by PTCRIS: 124736
Fundação para a Ciência e a Tecnologia, I.P.
2011 - 2014/01 Splicing-coupled mechanisms of chromatin remodeling and their global role in transcription
Provided by PTCRIS: 111451
Fundação para a Ciência e a Tecnologia, I.P.
2011 - 2013/12 The role of RNA polymerase II in splicing regulation
Provided by PTCRIS: 113440
Fundação para a Ciência e a Tecnologia, I.P.
2007 - 2010/08 Mechanisms of splicing regulation by U2AF proteins
Provided by PTCRIS: 69739
Fundação para a Ciência e a Tecnologia, I.P.

Projeto

Designação Financiadores
2019 - 2025/12/30 Contract "FCT CEEC Individual" - Targeting Intra-Tumor heterogeneity as a promising therapeutic strategy for cancer
CEECIND/02699/2017
Investigador responsável
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
Fundação para a Ciência e a Tecnologia, I.P.
2015 - 2019/12/30 Decoding pseudogene transcriptional regulation during cell differentiation
IF/00510/2014
Investigador responsável
Instituto de Medicina Molecular, Portugal
Fundação para a Ciência e a Tecnologia, I.P.
Produções

Publicações

Artigo em revista
  1. Vanda Póvoa; Cátia Rebelo de Almeida; Mariana Maia-Gil; Daniel Sobral; Micaela Domingues; Mayra Martinez-Lopez; Miguel de Almeida Fuzeta; et al. "Innate immune evasion revealed in a colorectal zebrafish xenograft model". Nature Communications (2021): https://doi.org/10.1038/s41467-021-21421-y.
    10.1038/s41467-021-21421-y
  2. Silva, Ana Patricia; Almeida, Afonso R.M.; Cachucho, Ana; Neto, João L; Demeyer, Sofie; Ramos de Matos, Mafalda; Hogan, Thea; et al. "Overexpression of wild type IL-7Ra promotes T-cell acute lymphoblastic leukemia/lymphoma". Blood (2021): http://dx.doi.org/10.1182/blood.2019000553.
    10.1182/blood.2019000553
  3. Andrade, Jorge; Shi, Chenyue; Costa, Ana S. H.; Choi, Jeongwoon; Kim, Jaeryung; Doddaballapur, Anuradha; Sugino, Toshiya; et al. "Control of endothelial quiescence by FOXO-regulated metabolites". Nature Cell Biology 23 4 (2021): 413-423. http://dx.doi.org/10.1038/s41556-021-00637-6.
    10.1038/s41556-021-00637-6
  4. Ana P. Rodrigo; Ana R. Grosso; Pedro V. Baptista; Alexandra R. Fernandes; Pedro M. Costa. "A Transcriptomic Approach to the Recruitment of Venom Proteins in a Marine Annelid". Toxins (2021): https://doi.org/10.3390/toxins13020097.
    10.3390/toxins13020097
  5. Ana P. Rodrigo; Vera M. Mendes; Bruno Manadas; Ana R. Grosso; António P. Alves de Matos; Pedro V. Baptista; Pedro M. Costa; Alexandra R. Fernandes. "Specific Antiproliferative Properties of Proteinaceous Toxin Secretions from the Marine Annelid Eulalia sp. onto Ovarian Cancer Cells". Marine Drugs (2021): https://doi.org/10.3390/md19010031.
    10.3390/md19010031
  6. Rita Francisco; Carlota Pascoal; Dorinda Marques-da-Silva; Sandra Brasil; Fernando M. Pimentel-Santos; Ruqaiah Altassan; Jaak Jaeken; et al. "New Insights into Immunological Involvement in Congenital Disorders of Glycosylation (CDG) from a People-Centric Approach". Journal of Clinical Medicine 9 7 (2020): 2092-2092. https://doi.org/10.3390/jcm9072092.
    10.3390/jcm9072092
  7. Prudêncio, Pedro; Rebelo, Kenny; Grosso, Ana Rita; Martinho, Rui Gonçalo; Carmo-Fonseca, Maria. "Analysis of Mammalian Native Elongating Transcript sequencing (mNET-seq) high-throughput data". Methods (2019): http://dx.doi.org/10.1016/j.ymeth.2019.09.003.
    10.1016/j.ymeth.2019.09.003
  8. Cunha, M.; Martins, C.; Grosso, A.R.; Costa, P.M.. "Mytilus galloprovincialis CYP1A-like mRNAs reveal closer proximity of mytilid CYP1A to the eumetazoan CYP2 family". Aquatic Toxicology 214 (2019): 105260. http://dx.doi.org/10.1016/j.aquatox.2019.105260.
    Publicado • 10.1016/j.aquatox.2019.105260
  9. de Matos, Mafalda; Posa, Ioana; Carvalho, Filipa; Morais, Vanessa; Grosso, Ana; de Almeida, Sérgio. "A Systematic Pan-Cancer Analysis of Genetic Heterogeneity Reveals Associations with Epigenetic Modifiers". Cancers 11 3 (2019): 391. http://dx.doi.org/10.3390/cancers11030391.
    Publicado • 10.3390/cancers11030391
  10. Vítor, Alexandra C.; Sridhara, Sreerama C.; Sabino, João C.; Afonso, Ana I.; Grosso, Ana R.; Martin, Robert M.; de Almeida, Sérgio F.. "Single-molecule imaging of transcription at damaged chromatin". Science Advances 5 1 (2019): eaau1249. http://dx.doi.org/10.1126/sciadv.aau1249.
    10.1126/sciadv.aau1249
  11. Nojima, Takayuki; Rebelo, Kenny; Gomes, Tomas; Grosso, Ana Rita; Proudfoot, Nicholas J.; Carmo-Fonseca, Maria. "RNA Polymerase II Phosphorylated on CTD Serine 5 Interacts with the Spliceosome during Co-transcriptional Splicing". Molecular Cell 72 2 (2018): 369-+. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000447630200017&KeyUID=WOS:000447630200017.
    10.1016/j.molcel.2018.09.004
  12. Mancio-Silva, Liliana; Slavic, Ksenija; Grilo Ruivo, Margarida T.; Grosso, Ana Rita; Modrzynska, Katarzyna K.; Vera, Iset Medina; Sales-Dias, Joana; et al. "Nutrient sensing modulates malaria parasite virulence". Nature 547 7662 (2017): 213-216. http://dx.doi.org/10.1038/nature23009.
    10.1038/nature23009
  13. Grosso, Ana Rita. "Introns Protect Eukaryotic Genomes from Transcription-Associated Genetic Instability.". Molecular cell (2017): http://europepmc.org/abstract/med/28757210.
    10.1016/j.molcel.2017.07.002
  14. Sridhara, Sreerama Chaitanya; Carvalho, Sílvia; Grosso, Ana Rita; Gallego-Paez, Lina Marcela; Carmo-Fonseca, Maria; de Almeida, Sérgio Fernandes. "Transcription Dynamics Prevent RNA-Mediated Genomic Instability through SRPK2-Dependent DDX23 Phosphorylation". Cell Reports 18 2 (2017): 334-343. http://dx.doi.org/10.1016/j.celrep.2016.12.050.
    10.1016/j.celrep.2016.12.050
  15. Machado, Miguel P.; Matos, Isa; Grosso, Ana R.; Schartl, Manfred; Coelho, Maria M.. "Non-canonical expression patterns and evolutionary rates of sex-biased genes in a seasonal fish". Molecular Reproduction and Development 83 12 (2016): 1102-1115. http://dx.doi.org/10.1002/mrd.22752.
    10.1002/mrd.22752
  16. Posa, Ioana; Carvalho, Silvia; Tavares, Joana; Grosso, Ana Rita. "A pan-cancer analysis of MYC-PVT1 reveals CNV-unmediated deregulation and poor prognosis in renal carcinoma". Oncotarget 7 30 (2016): http://dx.doi.org/10.18632/oncotarget.9487.
    10.18632/oncotarget.9487
  17. Muñoz-Ruiz, Miguel; Ribot, Julie C; Grosso, Ana R; Gonçalves-Sousa, Natacha; Pamplona, Ana; Pennington, Daniel J; Regueiro, José R; Fernández-Malavé, Edgar; Silva-Santos, Bruno. "TCR signal strength controls thymic differentiation of discrete proinflammatory ¿d T cell subsets". Nature Immunology 17 6 (2016): 721-727. http://dx.doi.org/10.1038/ni.3424.
    10.1038/ni.3424
  18. Jesus, T.F.; Grosso, A.R.; Almeida-Val, V.M.F.; Coelho, M.M.. "Transcriptome profiling of two Iberian freshwater fish exposed to thermal stress". Journal of Thermal Biology 55 (2016): 54-61. http://www.scopus.com/inward/record.url?eid=2-s2.0-84951081833&partnerID=MN8TOARS.
    10.1016/j.jtherbio.2015.11.009
  19. Grosso, Ana R; Leite, Ana P; Carvalho, Sílvia; Matos, Mafalda R; Martins, Filipa B; Vítor, Alexandra C; Desterro, Joana MP; Carmo-Fonseca, Maria; de Almeida, Sérgio F. "Pervasive transcription read-through promotes aberrant expression of oncogenes and RNA chimeras in renal carcinoma". eLife 4 (2015): http://dx.doi.org/10.7554/elife.09214.
    10.7554/elife.09214
  20. Álvarez, P.; Arthofer, Wolfgang; Coelho, Maria M.; Conklin, D.; Estonba, A.; Grosso, Ana R.; Helyar, S. J.; et al. "Genomic Resources Notes Accepted 1 June 2015 - 31 July 2015". Molecular Ecology Resources 15 6 (2015): 1510-1512. http://dx.doi.org/10.1111/1755-0998.12454.
    10.1111/1755-0998.12454
  21. Almeida-Val, Vera Maria Fonseca; Boscari, E.; Coelho, Maria Manuela; Congiu, L.; Grapputo, A.; Grosso, Ana Rita; Jesus, Tiago Filipe; et al. "Genomic Resources Notes accepted 1 April 2015 - 31 May 2015". Molecular Ecology Resources 15 5 (2015): 1256-1257. http://dx.doi.org/10.1111/1755-0998.12439.
    10.1111/1755-0998.12439
  22. Veigas, Bruno; Pedrosa, Pedro; Carlos, Fábio F; Mancio-Silva, Liliana; Grosso, Ana Rita; Fortunato, Elvira; Mota, Maria M; Baptista, Pedro V. "One nanoprobe, two pathogens: gold nanoprobes multiplexing for point-of-care". Journal of Nanobiotechnology 13 1 (2015): http://dx.doi.org/10.1186/s12951-015-0109-1.
    10.1186/s12951-015-0109-1
  23. Grosso, Ana Rita. "Mammalian NET-Seq Reveals Genome-wide Nascent Transcription Coupled to RNA Processing". Cell (2015):
    http://dx.doi.org/10.1016/j.cell.2015.03.027
  24. Nojima, Takayuki; Gomes, Tomás; Grosso, Ana Rita Fialho; Kimura, Hiroshi; Dye, Michael J.; Dhir, Somdutta; Carmo-Fonseca, Maria; Proudfoot, Nicholas J.. "Mammalian NET-Seq Reveals Genome-wide Nascent Transcription Coupled to RNA Processing". Cell 161 3 (2015): 526-540. http://dx.doi.org/10.1016/j.cell.2015.03.027.
    10.1016/j.cell.2015.03.027
  25. Grosso, A.R.; Leite, A.P.; Carvalho, S.; Matos, M.R.; Martins, F.B.; Vítor, A.C.; Desterro, J.M.P.; Carmo-Fonseca, M.; de Almeida, S.F.. "Pervasive transcription read-through promotes aberrant expression of oncogenes and RNA chimeras in renal carcinoma". eLife 4 NOVEMBER20 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84958191482&partnerID=MN8TOARS.
    10.7554/eLife.09214
  26. Dourado, C.G.; Duarte, M.A.; Grosso, A.R.; Bastos-Silveira, C.; Marrero, P.; Oliveira, P.; Paulo, O.S.; Dias, D.. "Phylogenetic origin of the endemic pigeons from Madeira (Columba trocaz) and Azores Islands (Columba palumbus azorica)". Journal of Ornithology 155 1 (2014): 71-82. http://www.scopus.com/inward/record.url?eid=2-s2.0-84891629909&partnerID=MN8TOARS.
    10.1007/s10336-013-0988-6
  27. Lança, T.; Costa, M.F.; Gonca¸lves-Sousa, N.; Rei, M.; Grosso, A.R.; Penido, C.; Silva-Santos, B.. "Protective role of the inflammatory CCR2/CCL2 chemokine pathway through recruitment of type 1 cytotoxic ¿d T lymphocytes to tumor beds". Journal of Immunology 190 12 (2013): 6673-6680. http://www.scopus.com/inward/record.url?eid=2-s2.0-84879112769&partnerID=MN8TOARS.
    10.4049/jimmunol.1300434
  28. Rodrigues, R.; Grosso, A.R.; Moita, L.. "Genome-Wide Analysis of Alternative Splicing during Dendritic Cell Response to a Bacterial Challenge". PLoS ONE 8 4 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84876265387&partnerID=MN8TOARS.
    10.1371/journal.pone.0061975
  29. Carvalho, S.; Raposo, A.C.; Martins, F.B.; Grosso, A.R.; Sridhara, S.C.; Rino, J.; Carmo-Fonseca, M.; De Almeida, S.F.. "Histone methyltransferase SETD2 coordinates FACT recruitment with nucleosome dynamics during transcription". Nucleic Acids Research 41 5 (2013): 2881-2893. http://www.scopus.com/inward/record.url?eid=2-s2.0-84876365300&partnerID=MN8TOARS.
    10.1093/nar/gks1472
  30. Schmolka, N.; Serre, K.; Grosso, A.R.; Rei, M.; Pennington, D.J.; Gomes, A.Q.; Silva-Santos, B.. "Epigenetic and transcriptional signatures of stable versus plastic differentiation of proinflammatory ¿d T cell subsets". Nature Immunology 14 10 (2013): 1093-1100. http://www.scopus.com/inward/record.url?eid=2-s2.0-84886723991&partnerID=MN8TOARS.
    10.1038/ni.2702
  31. Grosso, A.R.; De Almeida, S.F.; Braga, J.; Carmo-Fonseca, M.. "Dynamic transitions in RNA polymerase II density profiles during transcription termination". Genome Research 22 8 (2012): 1447-1456. http://www.scopus.com/inward/record.url?eid=2-s2.0-84864577725&partnerID=MN8TOARS.
    10.1101/gr.138057.112
  32. De Almeida, S.F.; Grosso, A.R.; Koch, F.; Fenouil, R.; Carvalho, S.; Andrade, J.; Levezinho, H.; et al. "Splicing enhances recruitment of methyltransferase HYPB/Setd2 and methylation of histone H3 Lys36". Nature Structural and Molecular Biology 18 9 (2011): 977-983. http://www.scopus.com/inward/record.url?eid=2-s2.0-80052445151&partnerID=MN8TOARS.
    10.1038/nsmb.2123
  33. Gomes, A.Q.; Correia, D.V.; Grosso, A.R.; Lança, T.; Ferreira, C.; Lacerda, J.F.; Barata, J.T.; da Silva, M.G.; Silva-Santos, B.. "Identification of a panel of ten cell surface protein antigens associated with immunotargeting of leukemias and lymphomas by peripheral blood ¿d t cells". Haematologica 95 8 (2010): 1397-1404. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956032245&partnerID=MN8TOARS.
    10.3324/haematol.2009.020602
  34. Mollet, I.G.; Ben-Dov, C.; Felício-Silva, D.; Grosso, A.R.; Eleutério, P.; Alves, R.; Staller, R.; Silva, T.S.; Carmo-Fonseca, M.. "Unconstrained mining of transcript data reveals increased alternative splicing complexity in the human transcriptome". Nucleic Acids Research 38 14 (2010): 4740-4754. http://www.scopus.com/inward/record.url?eid=2-s2.0-77955793696&partnerID=MN8TOARS.
    10.1093/nar/gkq197
  35. Albuquerque, S.S.; Carret, C.; Grosso, A.R.; Tarun, A.S.; Peng, X.; Kappe, S.H.I.; Prudêncio, M.; Mota, M.M.. "Host cell transcriptional profiling during malaria liver stage infection reveals a coordinated and sequential set of biological events". BMC Genomics 10 (2009): http://www.scopus.com/inward/record.url?eid=2-s2.0-67650520138&partnerID=MN8TOARS.
    10.1186/1471-2164-10-270
  36. Correia, D.V.; D'Orey, F.; Cardoso, B.A.; Lança, T.; Grosso, A.R.; DeBarros, A.; Martins, L.R.; Barata, J.T.; Silva-Santos, B.. "Highly active microbial phosphoantigen induces rapid yet sustained MEK/Erk- and PI-3K/Akt-mediated signal transduction in anti-tumor human ¿d T-cells". PLoS ONE 4 5 (2009): http://www.scopus.com/inward/record.url?eid=2-s2.0-66249119050&partnerID=MN8TOARS.
    10.1371/journal.pone.0005657
  37. Grosso, A.R.; Martins, S.; Carmo-Fonseca, M.. "The emerging role of splicing factors in cancer". EMBO Reports 9 11 (2008): 1087-1093. http://www.scopus.com/inward/record.url?eid=2-s2.0-55549143293&partnerID=MN8TOARS.
    10.1038/embor.2008.189
  38. Grosso, A.R.; Gomes, A.Q.; Barbosa-Morais, N.L.; Caldeira, S.; Thorne, N.P.; Grech, G.; von Lindern, M.; Carmo-Fonseca, M.. "Tissue-specific splicing factor gene expression signatures". Nucleic Acids Research 36 15 (2008): 4823-4832. http://www.scopus.com/inward/record.url?eid=2-s2.0-50849145126&partnerID=MN8TOARS.
    10.1093/nar/gkn463
  39. Abrantes, P.; Dimopoulos, G.; Grosso, A.R.; do Rosario, V.E.; Silveira, H.. "Chloroquine mediated modulation of Anopheles gambiae gene expression". PLoS ONE 3 7 (2008): http://www.scopus.com/inward/record.url?eid=2-s2.0-49749121787&partnerID=MN8TOARS.
    10.1371/journal.pone.0002587
  40. Amaral, A.J.; Silva, A.B.; Grosso, A.R.; Chikhi, L.; Bastos-Silveira, C.; Dias, D.. "Detection of hybridization and species identification in domesticated and wild quails using genetic markers". Folia Zoologica 56 3 (2007): 285-300. http://www.scopus.com/inward/record.url?eid=2-s2.0-36048956045&partnerID=MN8TOARS.
  41. Grosso, A.R.; Bastos-Silveira, C.; Coelho, M.M.; Dias, D.. "Columba palumbus Cyt b-like Numt sequence: Comparison with functional homologue and the use of universal primers". Folia Zoologica 55 2 (2006): 131-144. http://www.scopus.com/inward/record.url?eid=2-s2.0-33746876314&partnerID=MN8TOARS.
Capítulo de livro
  1. Pinto, Rui; Sobral, Daniel; Grosso, Ana Rita. "Comprehensive Detection of Pseudogenes Transcribed by Readthrough". 85-102. Springer {US, 2021.
    10.1007/978-1-0716-1503-4_6
  2. Grosso, Ana Rita; Carmo-Fonseca, Maria. "The Potential of Targeting Splicing for Cancer Therapy". In Nuclear Signaling Pathways and Targeting Transcription in Cancer, 313-336. Springer New York, 2013.
    Publicado • 10.1007/978-1-4614-8039-6_13
Tese / Dissertação
  1. Grosso, Ana Rita Fialho, 1979-; Fonseca, M. Carmo, 1959-; Tavaré, Simon. "New insights into alternative splicing using microarray technology". Doutoramento, 2009. http://catalogo.ul.pt/F/?func=item-global&doc_library=ULB01&type=03&doc_number=000576074.
  2. Grosso, Ana Rita. "Statistical Methodologies for the Analysis of DNA Microarray Data". Mestrado, Universidade de Lisboa Faculdade de Ciências, 2006.
Atividades

Orientação

Título / Tema
Papel desempenhado
Curso (Tipo)
Instituição / Organização
2020/01/01 - 2024/12/31 Coleoid venoms: Predicting cephalotoxin function and biotechnological applications from ecological and evolutionary traits
Coorientador de Cátia Gonçalves
Biotechnology (Doutoramento)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2019/01/01 - 2022/01/01 Decoding functional associations between genome organization and nuclear architecture
Coorientador de Silvia Carvalho
Basic and Applied Biology (Doutoramento)
Universidade do Porto Faculdade de Ciências, Portugal

Universidade do Porto Faculdade de Medicina, Portugal
2020/09/01 - 2021/09/30 A computational approach to identify target receptors of marine toxins in the human proteome: Potential biotechnological applications
Coorientador de Ines Cabral
Genética Molecular e Biomedicina (Mestrado)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2020/02/01 - 2020/06/01 Depicting drivers of intra-tumor heterogeneity
Orientador de João Milagaia
Biologia Celular e Molecular (Outra)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2020/02/01 - 2020/06/01 Deciphering Transcriptome Alterations underlying Metastasis Development
Orientador de Joana Gabriel
Biologia Celular e Molecular (Outra)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2019/02/01 - 2019/06/01 Deciphering expression-profiles of glycosylation factors through computational multi-omics
Orientador de Laura Duro
Biologia Celular e Molecular (Outra)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2019/02/01 - 2019/06/01 Unveil tissue-specific expression of glycosylation factors through computational multi-omics
Orientador de Valerio Fiori
Biologia Celular e Molecular (Outra)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2017 - 2018 Association of DNA modifications with somatic mutations in cancer
Orientador de João Sousa
Bioquímica (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
2016 - 2017 Depicting epigenetic mechanisms involved in the regulation of pseudogene expression
Orientador de Ana Margarida Ferreira
Biologia Molecular e Genética (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
2014 - 2015 Assessing Pseudogene Expression during Neural Differentiation by RNA-seq
Orientador de Luis Simões
Bioinformática e Biologia Computacional (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
2013 - 2015 LincRNA profile in clear cell Renal Cell Carcinoma using RNA-seq data
Orientador de Ioana Posa
Bioinformática e Biologia Computacional (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
2013 - 2014 Genome-wide profiling of RNA polymerase II and associated co- transcriptional processes using advanced NET-seq data
Orientador
Bioinformática e Biologia Computacional
Universidade de Lisboa Faculdade de Ciências, Portugal
2013 - 2014 LincRNA's Profile in SETD2 Downregulated Cells
Orientador de Joana Tavares
Bioinformática e Biologia Computacional (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
2012 - 2013 Study of the role of SETD2 mutations in clear renal Cell Carcinoma (ccRCC)
Coorientador de Catarina de Almeida
Bioestatística (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
2012 - 2013 Intragenic Initiation in SETD2 deficient cells
Coorientador de Miguel Pereira
Bioestatística (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação)
Instituição / Organização
2020/07/06 - 2020/07/10 EMBO Practical Course on "Deciphering tumour heterogeneity and evolution by integration of multi-omics data". This course aims to provide practical insights for cancer researchers regarding the potentials and challenges of using high throughput sequencing to estimate intra-tumoral diversity in its multiple facets. This will include the detection of mutational patterns, selection pressures and driver mutations, as well as techniques for the determination of subclonal diversity and clonal evolution. (2020/07/06 - 2020/07/10) (2020/07/06)
Oficina (workshop) (Coorganizador)

Consultoria / Parecer

Descrição da atividade Instituição / Organização
2014 - Atual Journal Reviewer: Bioinformatics, BMC Bioinformatics, BMC Cancer, BMC Genomics, Epigenomics, Oncotarget.

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2018 - Atual Molecular Genomics and Evolution Genética Molecular e Biomedicina (Mestrado integrado) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2018 - Atual Applied Computational Biology Genética Molecular e Biomedicina (Mestrado integrado) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2012 - 2015 Computational Biology in Biomedicine Bioinformática e Biologia Computacional (Mestrado integrado) Universidade de Lisboa Faculdade de Ciências, Portugal
2012 - 2015 Bioinformatics Oncobiologia (Mestrado integrado) Universidade de Lisboa Faculdade de Medicina, Portugal
Distinções

Prémio

2017 Pfizer Award
Pfizer Biofarmacêutica Sociedade Unipessoal Lda, Portugal
2011 Pfizer Award
Pfizer Biofarmacêutica Sociedade Unipessoal Lda, Portugal

Outra distinção

2018 FCT CEEC individual
Fundação para a Ciência e a Tecnologia, I.P., Portugal
2014 FCT Investigator
Fundação para a Ciência e a Tecnologia, I.P., Portugal
2010 FCT Post-Doctoral Fellowship
Fundação para a Ciência e a Tecnologia, I.P., Portugal
2006 PhD Fellowship
Fundação para a Ciência e a Tecnologia, I.P., Portugal