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Sónia Celeiro completed her MSc degree in Health Sciences in 2018 (School of Medicine/ University of Minho) and have a BSc degree in Biology-Geology (School of Sciences/ University of Minho) completed in 2016. Currently is doing his PhD in Health Sciences in ICVS/School of Medicine (University of Minho, Braga, Portugal) and Hospital Bambino Gesu - Department of Haemato-Oncology, Cell and Gene Therapy (Rome, Italy). Published 3 articles in journals. Has 1 section(s) of books. Participated in 21 event(s). Participated as Research Fellow in 2 project(s) and as a master's student in 2 work(s) integrated in the major project: "Deciphering the tumorigenic role of the tumour suppressor gene SPINT2 in solid tumours". Has received 2 awards and/or honors. In 2019, was awarded by Liga Portuguesa Contra o Cancro through the Portugal national contest: "Bolsa da Liga Portuguesa Contra o Cancro/ Fundação PT (2018)" with the scientific project: "Therapeutic relevance of the tumor suppressor gene SPINT2 in Melanoma". In the Ciência Vitae curriculum the most frequent terms in the context of scientific and technological output are: Cancer; Oncobiology; Cell biology; Melanoma; Cervical cancer; Gliomas; Leukemia; Signaling pathways; Targeted therapies; Biomarker; Tumor suppressor gene; Genetic and epigenetics; Methylation; SPINT2; Tumor microenviornment; Immune system; Cancer Metabolism; Cancer pH dynamics; Regulated cell death; Invasion; 3D cell culture; Propolis; . Experience in different techniques as qRT-PCR, phospho-arrays; western-blot, immunohistochemistry, functional assays in 2D and 3D culture models (wound-healing, migration, invasion, cell viability, tumor spheroid growth, metabolism assay (glucose consumption and extracellular lactate)), Chick Chorioallantoic Membrane (CAM) assay and animal experimentation (FELASA C).
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Identificação

Identificação pessoal

Nome completo
Sónia Pires Celeiro

Nomes de citação

  • Sónia Pires Celeiro

Identificadores de autor

Ciência ID
391C-3373-6D5A
ORCID iD
0000-0002-3211-6492

Endereços de correio eletrónico

  • soniaceleiro@med.uminho.pt (Profissional)
  • id9536@alunos.uminho.pt (Profissional)
  • sonia.celeiro94@gmail.com (Pessoal)

Telefones

Telefone
  • 253604837 (Profissional)

Moradas

  • Life and Health Sciences Research Institute (ICVS) Universidade do Minho Campus de Gualtar, 4710-057, Braga, Braga, Portugal (Profissional)

Websites

  • www.linkedin.com/in/sónia-celeiro-a3bab3196 (Profissional)

Domínios de atuação

  • Ciências Médicas e da Saúde - Ciências da Saúde
  • Ciências Naturais - Ciências Biológicas - Biologia
  • Ciências Naturais - Ciências Biológicas - Biologia Celular
  • Ciências Naturais - Ciências Biológicas - Biologia Molecular

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português (Idioma materno)
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Alemão Utilizador elementar (A1) Utilizador elementar (A1) Utilizador elementar (A1) Utilizador elementar (A1)
Formação
Grau Classificação
2021/01/01 - 2024
Em curso
 Health Sciences (Doutoramento)
Universidade do Minho Escola de Medicina, Portugal
2016/09 - 2018/10
Concluído
 Master in Health Sciences (Mestrado)
Universidade do Minho Escola de Medicina, Portugal
"“Study of functional role and therapeutic influence of the tumor suppressor gene SPINT2 in Melanoma”" (TESE/DISSERTAÇÃO)
 17
2017/03 - 2017/03
Concluído
 Cell Functional and Phenotypical Analysis (Curso de mestrado (conclusão do curso de especialização))
Universidade do Minho Escola de Medicina, Portugal
 16
2017/02 - 2017/03
Concluído
 Laboratory Rotation (Outros)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2017/01 - 2017/02
Concluído
 Laboratory Animals Sciences - Category C program according to FELASA recommendations. (Curso de mestrado (conclusão do curso de especialização))
Universidade do Minho Escola de Medicina, Portugal
 16
2016/12 - 2017
Concluído
 Laboratory Rotation (Outros)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2013/09 - 2016/07
Concluído
 Bachelor in Biology-Geology (Licenciatura)
Universidade do Minho Escola de Ciências, Portugal
 15
2014/10 - 2014/10
Concluído
 Course of Basic Life Support (BLS) (Outros)
European Resuscitation Council, Bélgica
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2020/02/01 - 2020/12/31 Investigador (Investigação) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2019/01 - 2019/12 Investigador (Investigação) Liga Portuguesa Contra o Cancro, Portugal
Universidade do Minho Escola de Medicina, Portugal
2016/10 - 2019/01 Estagiário de Investigação (Investigação) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Universidade do Minho Escola de Medicina, Portugal
Projetos

Bolsa

Designação Financiadores
2020/02/01 - 2020/12 Study of the anticancer effect of 3-Bromopyruvate (3-BrPa) in animal model systems of leukemia
UMINHO/BI/81/2020
Bolseiro de Investigação
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
 NEWGLAB PHARMA
Em curso
2019/01/01 - 2019/12/31 Therapeutic relevance of the tumor suppressor gene SPINT2 in Melanoma
Bolsa LPCC/Fundação PT 2018
Bolseiro de Investigação
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
 Liga Portuguesa Contra o Cancro
Em curso

Outro

Designação Financiadores
2021 - Atual Assessing the Antitumoral Activity of Portuguese Propolis Fractions in Melanoma
N/A
Investigador
Universidade do Minho Escola de Ciências, Portugal

Universidade do Minho Escola de Medicina, Portugal
Em curso
2020 - Atual Study of the anticancer effect of 3-Bromopyruvate (3-BrPa) in animal model systems of leukemia
N/A
Investigador
NEWGLAB PHARMA
2016 - Atual Deciphering the tumorigenic role of the tumour suppressor gene SPINT2 in solid tumours
N/A
Investigador
2017 - 2018 Study of functional role and therapeutic influence of the tumor suppressor gene SPINT2 in Melanoma - Master's student
N/A
Outra
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Em curso
2016/10 - 2016/12 Clinical relevance of tumour suppressor gene SPINT2 in Cervical Cancer - Laboratory rotation (Master degree)
N/A
Outra
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Em curso
Produções

Publicações

Artigo em revista
  1. Oliveira, Rafaela Dias; Sónia Pires Celeiro; Barbosa-Matos, Catarina; Freitas, Ana Sofia; Cardoso, Susana M.; Viana-Pereira, Marta; Almeida-Aguiar, Cristina; Baltazar, Fátima. Autor correspondente: Baltazar, Fátima. "Portuguese Propolis Antitumoral Activity in Melanoma Involves ROS Production and Induction of Apoptosis". Molecules 27 11 (2022): 3533. http://dx.doi.org/10.3390/molecules27113533.
    10.3390/molecules27113533
  2. Nshizirungu, Jean Paul; Bennis, Sanae; Mellouki, Ihsane; Sekal, Mohammed; Benajah, Dafr-Allah; Lahmidani, Nada; El Bouhaddouti, Hicham; et al. "Reproduction of the Cancer Genome Atlas (TCGA) and Asian Cancer Research Group (ACRG) Gastric Cancer Molecular Classifications and Their Association with Clinicopathological Characteristics and Overall Survival in Moroccan Patients". Disease Markers 2021 (2021): 1-12. http://dx.doi.org/10.1155/2021/9980410.
    Publicado • 10.1155/2021/9980410
  3. Nshizirungu, Jean Paul; Bennis, Sanae; Mellouki, Ihsane; Benajah, Dafr-Allah; Lahmidani, Nada; El Bouhaddoutti, Hicham; Ibn Majdoub, Karim; et al. "Microsatellite Instability Analysis in Gastric Carcinomas of Moroccan Patients". Genetic Testing and Molecular Biomarkers 25 2 (2021): 116-123. http://dx.doi.org/10.1089/gtmb.2020.0146.
    10.1089/gtmb.2020.0146
  4. Pereira, Márcia Santos; Celeiro, Sónia Pires; Costa, Ângela Margarida; Pinto, Filipe; Popov, Sergey; de Almeida, Gisele Caravina; Amorim, Júlia; et al. "Loss of SPINT2 expression frequently occurs in glioma, leading to increased growth and invasion via MMP2". Cellular Oncology 43 1 (2019): 107-121. http://dx.doi.org/10.1007/s13402-019-00475-7.
    Publicado • 10.1007/s13402-019-00475-7
Capítulo de livro
  1. Sónia Pires-Celeiro; Fátima Baltazar; Marta Viana-Pereira. "3D culture systems as models for solid tumors and cancer metabolism". In Biomaterials for 3D Tumor Modeling, editado por Kundu, Subhas; Reis, Rui L.. London, Reino Unido: Elsevier, 2020.
    Publicado
Poster em conferência
  1. Rafaela Dias Oliveira; Sónia Pires-Celeiro; Baltazar, Fátima; Almeida-Aguiar, Cristina. "Assessing the Antitumoral Activity of Portuguese Propolis Fractions in Melanoma". Trabalho apresentado em CUTANEOUS MELANOMA: FROM WHERE TO WHERE?, 2021.
  2. Sónia Pires-Celeiro; Baltazar, Fátima; Reis, Rui Manuel; Viana-Pereira, Marta. "SPINT2: a potential biomarker for melanoma patients". Trabalho apresentado em II ASPIC-ASEICA International Meeting - Current Trends in Precision Medicine in Cancer, 2021.
  3. Sónia Pires-Celeiro; Fátima Balazar; Reis, Rui Manuel; Marta Viana-Pereira. "SPINT2 downregulation in Melanoma influences EMT". Trabalho apresentado em EACR 2021 Virtual Congress, 2021.
  4. Joana Pereira-Vieira; Sónia Pires-Celeiro; Fátima Baltazar. "Targeting glycolytic metabolism as a therapeutic strategy for Acute Myeloid Leukemia". Trabalho apresentado em EACR 2021 Virtual Congress, 2021.
  5. Sónia Pires-Celeiro; Marta Viana-Pereira. "SPINT2 role and therapeutic influence in Melanoma". Trabalho apresentado em Cancer Biology: From Basic to Translational Research, 2020.
  6. Joana Pereira-Vieira; Sónia Pires-Celeiro; Fátima Baltazar. "3-bromopyruvate boosts the effect of chemotherapy in acute myeloid leukaemia by reducing cell antioxidant defence". Trabalho apresentado em Cancer Biology: From Basic to Translational Research, 2020.
  7. Sónia Pires-Celeiro. "SPINT2 as a therapeutic biomarker in Melanoma". Trabalho apresentado em ISCam 2019, 2019.
  8. Sónia Pires-Celeiro. "Study of functional role and therapeutic influence of the tumor suppressor gene SPINT2 in Melanoma". Trabalho apresentado em ICVS Open Day 2019, 2019.
  9. Sónia Pires-Celeiro; Rui M. Reis; Marta Viana-Pereira. "Study of functional role and therapeutic influence of the tumor suppressor gene SPINT2 in Melanoma". Trabalho apresentado em 25th Porto Cancer Meeting, 2018, 2018.
  10. Sónia Pires-Celeiro; Rui M. Reis; Marta Viana-Pereira. "Study of functional role and therapeutic influence of the tumor suppressor gene SPINT2 in Melanoma". Trabalho apresentado em ICVS Open Day 2018, 2018.
Resumo em conferência
  1. Nshizirungu, J.; Van Cutsem, E.; Bennis, S.; Mellouki, I.; Sekal, M.; Benajah, D.; Lahmidani, N.; et al. "P-195 Gastric adenocarcinoma classification: Association with clinicopathological features and overall survival in Moroccan patients". 2021.
    Publicado • 10.1016/j.annonc.2021.05.250
  2. Sónia Pires-Celeiro; Rui M. Reis; Marta Viana-Pereira. "Abstract PN9: Study of functional role and therapeutic influence of the tumor suppressor gene SPINT2 in melanoma". Trabalho apresentado em ICVS Open Day 2019, Braga, 2019.
    Aceite para publicação
  3. Sónia Pires-Celeiro; Rui M. Reis; Marta Viana-Pereira. "Abstract P15: SPINT2 as a therapeutic biomarker in Melanoma". Trabalho apresentado em ISCaM 2019, Braga, 2019.
    Aceite para publicação
  4. Sónia Pires-Celeiro; Rui M. Reis; Marta Viana-Pereira. "Abstract PN10: Study of functional role and therapeutic influence of the tumor suppressor gene SPINT2 in melanoma". Trabalho apresentado em ICVS Open Day 2018, Braga, 2018.
    Aceite para publicação
  5. Sónia Pires-Celeiro; Rui M. Reis; Marta Viana-Pereira. "Abstract 43: Study of functional role and therapeutic influence of the tumor suppressor gene SPINT2 in Melanoma". Trabalho apresentado em 25th Porto Cancer Meeting, Braga, 2018.
    Aceite para publicação
Tese / Dissertação
  1. Celeiro, Sónia. "Study of functional role and therapeutic influence of the tumor suppressor gene SPINT2 in Melanoma (18/20)". Mestrado, Universidade do Minho Escola de Medicina, 2018.
Atividades

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2020/11 - 2020/12 "Therapeutic relevance of the tumor suppressor gene SPINT2 in Melanoma" Supervisor of Beatriz Peixoto (Laboratory Rotation-Master student) Beatriz Peixoto laboratory rotation was supervised by me and Dr. Marta Viana-Pereira. Genetically modulated melanoma cell lines (SPINT2 overexpression) were used to evaluate SPINT2 therapeutic influence. 2D and 3D cell culture models and specific functional studies with these models were taught to the student (wound-healing assay, tumor spheroid-based migration assay on matrix protein and tumor spheroid growt
Coorientador
 Ciências da Saúde (Mestrado)
Universidade do Minho Escola de Medicina, Portugal

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação) 		Instituição / Organização
2021/04 - 2021/04 III Jornadas da Ciência - Development of 3D culture systems for in vitro study of tumour pathophysiology (2021/04/08 - 2021/04/10)
Oficina (workshop) (Outra)
 Universidade do Minho Escola de Ciências, Portugal

Participação em evento

Descrição da atividade
Tipo de evento 		Nome do evento
Instituição / Organização
2023/01/17 - Atual Learn about the fundamental differences between conventional 2D and 3D cell culture approaches and the pros and cons of using them for drug development. Learn how tumor microenvironment affects tissue organization and response to treatment and why it is crucial to incorporate it into pre-clinical models.
Outro
 Multimodal Analysis of Anticancer Drug Testing In Tumor-Specific 3D Cell Culture Models - Webinar
Tecan Group Ltd, Suiça
2022/12/12 - Atual Explore the use of hPSC-derived models to study human health, development, and disease Understand the differentiation and characterization of hPSC-derived choroid plexus organoids Discover a protocol that helps to get to the desired clone quickly, with demonstrated savings of valuable reagents, media, and plastic
Outro
 Novel methods for the development of stem cell-derived 2D and 3D models - Webinar
SelectScience, Reino Unido

STEMCELL Technologies Inc, Canadá
2021/10/14 - 2021/10/15 Disseminate and promote the work developed in the Portugal and Spanish countries to create communication channels and collaboration opportunities among cancer researchers. In addition, emphasis on fostering essential connections among basic, clinical and translational cancer researchers.
Encontro
 II ASPIC-ASEICA International Meeting - Current Trends in Precision Medicine in Cancer
Associação Portuguesa de Investigação em Cancro, Portugal
2021/07/14 - 2021/07/14 Business projects that resulted from the science-based ideas supported by HiTech were presented.
Outro
 HiTech 2021 - Innovation from Science
HiSeedTech, Portugal
2021/06/09 - 2021/06/12 A virtual congress dedicated to basic, preclinical and translational cancer research across a wide breadth of topics.
Congresso
 EACR 2021 Virtual Congress
European Association For Cancer Research, Reino Unido
2021/05/15 - 2021/05/15 Medical meeting about the innovative medicines and appropriate therapeutic strategies in Melanoma
Conferência
 II Encontro de Melanoma e Tumores Cutâneos Não Melanoma do Alentejo
2021/04/26 - 2021/04/26 The Congress focused on the latest developments and findings in immuno-oncology therapy as well as targeted therapy.
Conferência
 The Virtual congress on Modern Oncology
VIM2021, Israel
2021/04/13 - 2021/04/13 Structuring and problem solving - workshop within the Educational Training Program at School of Medicine - University of Minho, Braga, Portugal
Oficina (workshop)
 Transversal Skills and Employability Workshop
Universidade do Minho Escola de Medicina, Portugal
2021/04/09 - 2021/04/09 Webinar about various projects manly focused on genetic, epigenetic and epidemiological aspects of tumor models to contribute for a better understanding of cancer and the way to fight it.
Outro
 VI Jornadas de Investigação em Oncologia em Portugal
Liga Portuguesa Contra o Cancro, Portugal
2021/03/19 - 2021/03/19 Time management - workshop within the Educational Training Program at School of Medicine - University of Minho, Braga, Portugal.
Oficina (workshop)
 Transversal Skills and Employability Workshop
Universidade do Minho Escola de Medicina, Portugal
2021/03/13 - 2021/03/13 I Jornadas de Imunoterapia do Alentejo e Algarve
Outro
 I Jornadas de Imunoterapia do Alentejo e Algarve
2021/01/21 - 2021/01/21 Preparation for selection interviews - workshop within the Educational Training Program at School of Medicine - University of Minho, Braga, Portugal.
Oficina (workshop)
 Transversal Skills and Employability Workshop
Universidade do Minho Escola de Medicina, Portugal
2020/09/25 - 2020/09/25 Different thematics of tumor complexity (genetics, biomarkers, tumor microenvironment, tumor metabolism, and new potential therapeutic targets) was addressed, as well as the application of knowledge to improve the diagnosis or treatments of cancer patients.
Outro
 WEBINAR: Cancer Biology: From Basic To Translational Research
Liga Portuguesa Contra o Cancro, Portugal
2020/07/14 - 2020/07/14 Drug attrition rates from high throughput screening 2D models have instigated the need for more relevant and clinically predictive models. Researchers have been using a variety of 3D techniques/ models and explore the impact on their research. The real question is can these assays bridge the gap between the convenience of conventional 2D models and the biological relevance of animal models and produce assays that are truly fit for purpose?
Outro
 ELRIG webinar: 3D Models – An Alternative to or in combination with traditional 2D Assays for Drug Discovery
ELRIG, Reino Unido

Nexcelom Bioscience, Estados Unidos
2020/06/23 - 2020/06/23 Unlocking the complexities of drug discovery is an ongoing challenge. In this context, in vitro disease models have provided important tools for the development of new drugs, serving as low-cost screening platforms for drug therapies.
Outro
 3D Cell Culture Models: Challenges and Optimized Assays (Webinar)
Corning Inc, Estados Unidos

Promega Biotech Ibérica, Espanha
2019/10/17 - 2019/10/19 ISCaM 2019 6th Annual meeting CANCER METABOLIC REWIRING: MAPPING THE ROAD TO CLINICAL TRANSLATION
Conferência
 ISCaM 2019 6th Annual meeting CANCER METABOLIC REWIRING: MAPPING THE ROAD TO CLINICAL TRANSLATION
Universidade do Minho, Portugal

Universidade do Minho Escola de Ciências, Portugal

Universidade do Minho Escola de Medicina, Portugal

Universidade do Minho Centro de Biologia Molecular e Ambiental, Portugal

Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2019/10/03 - 2019/10/03 How to write great papers and get published. Understanding and benefiting from the publishing process. By Elsevier Researcher Academy.
Oficina (workshop)
 How to Write a Great Research Paper, and Get it Accepted by a Good Journal
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2019/04 - 2019/04 ICVS Open Day 2019
Encontro
 ICVS Open Day
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2019/01 - 2019/01 Nanotechnology for Therapy and Diagnostics, nanoGateway Winter School 2019
Conferência
 Nanotechnology for Therapy and Diagnostics
International Iberian Nanotechnology Laboratory, Portugal
2018/04/06 - 2018/04/06 ICVS Open Day 2018
Encontro
 ICVS Open Day
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2018/04 - 2018/04 25th Porto Cancer meeting 2018 - Cancer Wars: The Immune Force Awakens
Conferência
 25th Porto Cancer Meeting 25th Porto Cancer meeting - Cancer Wars: The Immune Force Awakens
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2016 - 2016 3ª Jornada da Oferta Pós-graduada da ECUM "UM Futuro com Ciência"
Conferência
 3ª Jornada da Oferta Pós-graduada da ECUM "UM Futuro com Ciência"
Universidade do Minho Escola de Ciências, Portugal
2014 - 2014 Seminar given by aerospace engineer Bobak Ferdowsi about the "Curiosity" spacecraft that was launched on Mars. It is a robotic vehicle which is collecting photographs and samples for analysis, with the main purpose of identifying life forms.
Seminário
 Palestra de Bobak Ferdowsi (NASA)
Universidade do Minho Escola de Ciências, Portugal

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2017/10/26 - 2017/10/26 Experimental Approaches in Oncobiology: Lab II Immunohistochemistry method Fundamentals in Genetics, Development and Neoplasia (Curso de mestrado (conclusão do curso de especialização)) Universidade do Minho Escola de Medicina, Portugal

Tutoria

Tópico Nome do aluno
2021 - Atual Assessing the in vitro antimicrobial and antitumor activity of Portuguese propolis - Rafaela Oliveira (Master's student) Rafaela Oliveira
2019/11 - 2019/11 SPINT2 influence in melanoma metabolism - Laboratory Rotation - Master's student Adriana Faria
2018/12 - 2019 Microsatellite instability in gastric cancer - PhD student Jean Paul
2018/05 - 2018/05 Laboratory Rotation - PhD student Matilde Neto
2017/11 - 2018/01 Laboratory Rotation-Master's student Inês Fernandes Lages
2017/07 - 2017/09 Master thesis - Medical student Bruno Peixoto
2017/07/01 - 2017/07/31 Laboratory Rotation-Erasmus/Medical student Bertha Elena Arangure
Distinções

Prémio

2020 Best poster in Cancer Biology: From Basic To Translational Research 2020 (Webinar)
Liga Portuguesa Contra o Cancro, Portugal
2019 Project winner of the national contest: "Bolsa da Liga Portuguesa Contra o Cancro/ Fundação PT (2018)"
Liga Portuguesa Contra o Cancro, Portugal