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Sónia Celeiro holds a degree in Biology-Geology (2013–2016) and a master’s degree in Health Sciences from the University of Minho, completed in 2018. Since January 2021, she has been a PhD student in the Health Sciences Doctoral Program at the University of Minho, focusing her dissertation on understanding the role and therapeutic potential of SPINT2 in melanoma. Her research is being conducted at the Life and Health Sciences Research Institute (ICVS) in Braga, Portugal, and at the Department of Haemato-Oncology, Cell and Gene Therapy at Bambino Gesù Children’s Hospital in Rome, Italy. She has published six articles, one book chapter, and presented thirteen conference posters. Throughout her academic journey, she has mentored nine students and was awarded in 2019 by the Liga Portuguesa Contra o Cancro through the national competition "Bolsa da Liga Portuguesa Contra o Cancro / Fundação PT (2018)" for her scientific project titled "Therapeutic relevance of the tumor suppressor gene SPINT2 in Melanoma." In her Ciência Vitae curriculum, the most frequently referenced terms in the context of her scientific and technological outputs include: SPINT2, melanoma, biomarker, oncobiology, cancer, and molecular targeted therapies. She has hands-on experience with a variety of techniques, including qRT-PCR, western blotting, immunohistochemistry, and functional assays in both 2D and 3D culture models (wound-healing, migration, invasion, cell viability, tumor spheroid growth), as well as drug screening and the Chick Chorioallantoic Membrane (CAM) assay.
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Identification

Personal identification

Full name
Sónia Pires Celeiro

Citation names

  • Sónia Pires Celeiro

Author identifiers

Ciência ID
391C-3373-6D5A
ORCID iD
0000-0002-3211-6492

Email addresses

  • id9536@alunos.uminho.pt (Professional)
  • sonia.celeiro94@gmail.com (Personal)

Telephones

Telephone
  • 253604837 (Professional)

Addresses

  • Life and Health Sciences Research Institute (ICVS) Universidade do Minho Campus de Gualtar, 4710-057, Braga, Braga, Portugal (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Health Sciences
  • Medical and Health Sciences - Clinical Medicine - Oncology
  • Natural sciences - Biological Sciences - Cell Biology
  • Natural sciences - Biological Sciences - Molecular Biology

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
German Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
Education
Degree Classification
2021/01/01 - 2025
Ongoing
 Health Sciences (Doutoramento)
Universidade do Minho Escola de Medicina, Portugal
2022/03/31 - 2022/04/08
Concluded
 Single-cell genomics for beginners (Curso de doutoramento (conclusão de unidades curriculares))
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
 Approved
2016/09 - 2018/10
Concluded
 Master in Health Sciences (Mestrado)
Universidade do Minho Escola de Medicina, Portugal
"Study of functional role and therapeutic influence of the tumor suppressor gene SPINT2 in Melanoma (18/20)" (THESIS/DISSERTATION)
 17
2017/03 - 2017/03
Concluded
 Cell Functional and Phenotypical Analysis (Curso de mestrado (conclusão do curso de especialização))
Universidade do Minho Escola de Medicina, Portugal
 16
2017/01 - 2017/02
Concluded
 Laboratory Animals Sciences - Category C program according to FELASA recommendations. (Curso de mestrado (conclusão do curso de especialização))
Universidade do Minho Escola de Medicina, Portugal
 16
2013/09 - 2016/07
Concluded
 Biology-Geology (Licenciatura)
Universidade do Minho Escola de Ciências, Portugal
 15
Affiliation

Science

Category
Host institution 		Employer
2020/02/01 - 2020/12/31 Researcher (Research) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2019/01 - 2019/12 Researcher (Research) Liga Portuguesa Contra o Cancro, Portugal
Universidade do Minho Escola de Medicina, Portugal

Others

Category
Host institution 		Employer
2021 - Current PhD Student Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2022 - 2024 PhD Student Ospedale Pediatrico Bambino Gesù IRCCS, Italy
Ospedale Pediatrico Bambino Gesù IRCCS, Italy
2016/10 - 2018/01 Master's Student Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Universidade do Minho Escola de Medicina, Portugal
Projects

Grant

Designation Funders
2021/01/01 - Current Deciphering the role of the serine protease inhibitor SPINT2 managing melanoma tumorigenesis and therapeutic response
2020.05779.BD
PhD Student Fellow
Fundação para a Ciência e a Tecnologia
Ongoing
2020/02/01 - 2020/12 Study of the anticancer effect of 3-Bromopyruvate (3-BrPa) in animal model systems of leukemia
UMINHO/BI/81/2020
Research Fellow
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
 NEWGLAB PHARMA
2019/01/01 - 2019/12/31 Therapeutic relevance of the tumor suppressor gene SPINT2 in Melanoma
Bolsa LPCC/Fundação PT 2018
Research Fellow
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
 Liga Portuguesa Contra o Cancro

Other

Designation Funders
2022 - Current Establishment of an invasion signature for pediatric high-grade glioma
N/A
Researcher
Children with Cancer UK
2016 - Current Deciphering the tumorigenic role of the tumour suppressor gene SPINT2 in solid tumours
N/A
Researcher
2022 - 2024 The role of Rho-Kinase in Diffuse Midline Glioma cell dissemination
N/A
Researcher
Ospedale Pediatrico Bambino Gesù IRCCS, Italy
 FONDAZIONE HEAL
2022 - 2024 Immunity in cancer spreading and metastasis (ISM) program project
AIRC 5x1000
Researcher
Ospedale Pediatrico Bambino Gesù IRCCS, Italy
 Fondazione Italiana per la Ricerca sul Cancro Airc
2021 - 2023 Assessing the Antitumoral Activity of Portuguese Propolis Fractions in Melanoma
N/A
Researcher
Universidade do Minho Escola de Ciências, Portugal

Universidade do Minho Escola de Medicina, Portugal
2020 - 2022 Study of the anticancer effect of 3-Bromopyruvate (3-BrPa) in animal model systems of leukemia
N/A
Researcher
NEWGLAB PHARMA
2017 - 2018 Study of functional role and therapeutic influence of the tumor suppressor gene SPINT2 in Melanoma - Master's student
N/A
Other
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2016/10 - 2016/12 Clinical relevance of tumour suppressor gene SPINT2 in Cervical Cancer - Laboratory rotation (Master degree)
N/A
Other
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Outputs

Publications

Book chapter
  1. Sónia Pires-Celeiro; Fátima Baltazar; Marta Viana-Pereira. "3D culture systems as models for solid tumors and cancer metabolism". In Biomaterials for 3D Tumor Modeling, edited by Kundu, Subhas; Reis, Rui L.. London, United Kingdom: Elsevier, 2020.
    Published
Conference poster
  1. Joana Pereira-Vieira; Sara Granja; Sónia Pires Celeiro; Catarina Barbosa-Matos; Ana Preto; Odília Queirós; Young H. Ko; Margarida Casal; Fátima Baltazar. "3-Bromopiruvato aumenta o efeito da quimioterapia na leucemia mieloide aguda por um mecanismo mediado por ROS". Paper presented in 6th National Meeting of Young Researchers in Oncology (6º ENJIO), 2024.
  2. Giulia Pericoli; Sónia Pires Celeiro; Marsha Pellegrino; Emmanuel de Billy; Ginevra Zanni; Mara Vinci. "The role of Rho-Kinase in Diffuse Midline Glioma cell dissemination". Paper presented in EACR 2024, 2024.
  3. Sónia Pires Celeiro; Rafaela Dias Oliveira; Vinicius de Lima Vazquez; Fátima Baltazar; Rui Manuel Reis; Marta Viana-Pereira. "SPINT2 reduces melanoma aggressiveness and improves therapeutic response". Paper presented in EACR 2024: "Innovative Cancer Science", 2024.
  4. Sónia Pires Celeiro; Fátima Baltazar; Rui M. Reis; Marta Viana-Pereira. "SPINT2 downregulation increases melanoma aggressiveness features". Paper presented in 5th ASPIC International Congress, 2022.
  5. Rafaela Dias Oliveira; Sónia Pires-Celeiro; Baltazar, Fátima; Almeida-Aguiar, Cristina. "Assessing the Antitumoral Activity of Portuguese Propolis Fractions in Melanoma". Paper presented in CUTANEOUS MELANOMA: FROM WHERE TO WHERE?, 2021.
  6. Sónia Pires-Celeiro; Baltazar, Fátima; Reis, Rui Manuel; Viana-Pereira, Marta. "SPINT2: a potential biomarker for melanoma patients". Paper presented in II ASPIC-ASEICA International Meeting - Current Trends in Precision Medicine in Cancer, 2021.
  7. Sónia Pires-Celeiro; Fátima Balazar; Reis, Rui Manuel; Marta Viana-Pereira. "SPINT2 downregulation in Melanoma influences EMT". Paper presented in EACR 2021 Virtual Congress, 2021.
  8. Joana Pereira-Vieira; Sónia Pires-Celeiro; Fátima Baltazar. "Targeting glycolytic metabolism as a therapeutic strategy for Acute Myeloid Leukemia". Paper presented in EACR 2021 Virtual Congress, 2021.
  9. Sónia Pires-Celeiro; Marta Viana-Pereira. "SPINT2 role and therapeutic influence in Melanoma". Paper presented in Cancer Biology: From Basic to Translational Research, 2020.
  10. Joana Pereira-Vieira; Sónia Pires-Celeiro; Fátima Baltazar. "3-bromopyruvate boosts the effect of chemotherapy in acute myeloid leukaemia by reducing cell antioxidant defence". Paper presented in Cancer Biology: From Basic to Translational Research, 2020.
  11. Sónia Pires-Celeiro. "SPINT2 as a therapeutic biomarker in Melanoma". Paper presented in ISCam 2019, 2019.
  12. Sónia Pires-Celeiro. "Study of functional role and therapeutic influence of the tumor suppressor gene SPINT2 in Melanoma". Paper presented in ICVS Open Day 2019, 2019.
  13. Sónia Pires-Celeiro; Rui M. Reis; Marta Viana-Pereira. "Study of functional role and therapeutic influence of the tumor suppressor gene SPINT2 in Melanoma". Paper presented in 25th Porto Cancer Meeting, 2018, 2018.
Journal article
  1. Pereira-Vieira, Joana; Granja, Sara; Sónia Pires Celeiro; Barbosa-Matos, Catarina; Preto, Ana; Queirós, Odília; Ko, Young Hee; Casal, Margarida; Baltazar, Fátima. "3-Bromopyruvate boosts the effect of chemotherapy in acute myeloid leukemia by a pro-oxidant mechanism". Free Radical Biology and Medicine 234 (2025): 192-202. https://doi.org/10.1016/j.freeradbiomed.2025.04.017.
    10.1016/j.freeradbiomed.2025.04.017
  2. Ana Rita Caetano; Oliveira, Rafaela; Sónia Pires Celeiro; Ana Sofia Freitas; Susana M. Cardoso; M. Sameiro T. Gonçalves; Maria de Fátima Monginho Baltazar; Almeida-Aguiar, Cristina. "Phenolic Compounds Contribution to Portuguese Propolis Anti-melanoma Activity". Molecules (2023): https://www.mdpi.com/1420-3049/28/7/3107.
    Published • 10.3390/molecules28073107
  3. Oliveira, Rafaela Dias; Sónia Pires Celeiro; Barbosa-Matos, Catarina; Freitas, Ana Sofia; Cardoso, Susana M.; Viana-Pereira, Marta; Almeida-Aguiar, Cristina; Baltazar, Fátima. Corresponding author: Baltazar, Fátima. "Portuguese Propolis Antitumoral Activity in Melanoma Involves ROS Production and Induction of Apoptosis". Molecules 27 11 (2022): 3533. http://dx.doi.org/10.3390/molecules27113533.
    10.3390/molecules27113533
  4. Nshizirungu, Jean Paul; Bennis, Sanae; Mellouki, Ihsane; Sekal, Mohammed; Benajah, Dafr-Allah; Lahmidani, Nada; El Bouhaddouti, Hicham; et al. "Reproduction of the Cancer Genome Atlas (TCGA) and Asian Cancer Research Group (ACRG) Gastric Cancer Molecular Classifications and Their Association with Clinicopathological Characteristics and Overall Survival in Moroccan Patients". Disease Markers 2021 (2021): 1-12. http://dx.doi.org/10.1155/2021/9980410.
    Published • 10.1155/2021/9980410
  5. Nshizirungu, Jean Paul; Bennis, Sanae; Mellouki, Ihsane; Benajah, Dafr-Allah; Lahmidani, Nada; El Bouhaddoutti, Hicham; Ibn Majdoub, Karim; et al. "Microsatellite Instability Analysis in Gastric Carcinomas of Moroccan Patients". Genetic Testing and Molecular Biomarkers 25 2 (2021): 116-123. http://dx.doi.org/10.1089/gtmb.2020.0146.
    10.1089/gtmb.2020.0146
  6. Pereira, Márcia Santos; Celeiro, Sónia Pires; Costa, Ângela Margarida; Pinto, Filipe; Popov, Sergey; de Almeida, Gisele Caravina; Amorim, Júlia; et al. "Loss of SPINT2 expression frequently occurs in glioma, leading to increased growth and invasion via MMP2". Cellular Oncology 43 1 (2019): 107-121. http://dx.doi.org/10.1007/s13402-019-00475-7.
    Published • 10.1007/s13402-019-00475-7
Thesis / Dissertation
  1. Celeiro, Sónia. "Study of functional role and therapeutic influence of the tumor suppressor gene SPINT2 in Melanoma (18/20)". Master, Universidade do Minho Escola de Medicina, 2018.
Activities

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2025/02/04 - Current The 2nd edition of “Cancro em Perspetiva” brought together researchers, physicians, patient associations, and students to discuss the critical role of clinical trials and the challenges faced in the fight against cancer. The event featured scientific presentations and an interactive roundtable that fostered meaningful dialogue. Participants also shared their work through scientific posters, providing an opportunity to disseminate knowledge and engage with both academic and non-academic audiences. (2025/02/04)
Conference (Member of the Organising Committee)
 Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2024/05/17 - 2024/05/17 This training offers comprehensive instruction on FlowJo software, a leading tool for analyzing flow cytometry data.
Workshop
 FlowJo Training (Basic and Advanced)
Università degli Studi di Roma La Sapienza, Italy
2023/12/07 - 2023/12/07 Professor Johanna Joyce focused on the pivotal role of the tumor microenvironment (TME) in cancer progression and therapeutic response.
Seminar
 EACR ‘Meet the Expert' Webinar with Prof. Johanna Joyce: The importance of the local microenvironment - in cancer and in science
European Association For Cancer Research, United Kingdom
2023/03/22 - 2023/03/22 The event focused on the latest 3D organoid and spheroid discoveries, highlighting the potential of organoids as research tools and alternatives to animal models and single cell type models
Conference
 World Organoid Research Day 2023
Organoidspheroid, United Kingdom
2023/02/15 - 2023/02/15 Learn about the RASTRUM platform for developing matrix-embedded cancer organoids to study the disease mechanisms behind cell migration and invasion in cancer biology, and to target these processes through drug treatments.
Seminar
 Cancer cells on the move: 3D bioprinting and tracking cell movement
Inventia Life Science Pty Ltd, Australia
2023/01/17 - 2023/01/17 Learn about the fundamental differences between conventional 2D and 3D cell culture approaches and the pros and cons of using them for drug development.
Seminar
 Multimodal Analysis of Anticancer Drug Testing In Tumor-Specific 3D Cell Culture Models - Webinar
Tecan Group Ltd, Switzerland
2021/07/14 - 2021/07/14 Business projects that resulted from the science-based ideas supported by HiTech were presented.
Other
 HiTech 2021 - Innovation from Science
HiSeedTech, Portugal
2021/06/09 - 2021/06/12 A virtual congress dedicated to basic, preclinical and translational cancer research across a wide breadth of topics.
Congress
 EACR 2021 Virtual Congress
European Association For Cancer Research, United Kingdom
2021/05/15 - 2021/05/15 Medical meeting about the innovative medicines and appropriate therapeutic strategies in Melanoma
Conference
 II Encontro de Melanoma e Tumores Cutâneos Não Melanoma do Alentejo
2021/04/26 - 2021/04/26 The Congress focused on the latest developments and findings in immuno-oncology therapy as well as targeted therapy.
Congress
 The Virtual congress on Modern Oncology
VIM2021, Israel
2021/04/13 - 2021/04/13 Structuring and problem solving - workshop within the Educational Training Program at School of Medicine - University of Minho, Braga, Portugal
Workshop
 Transversal Skills and Employability Workshop
Universidade do Minho Escola de Medicina, Portugal
2021/04/09 - 2021/04/09 Webinar about various projects manly focused on genetic, epigenetic and epidemiological aspects of tumor models to contribute for a better understanding of cancer and the way to fight it.
Other
 VI Jornadas de Investigação em Oncologia em Portugal
Liga Portuguesa Contra o Cancro, Portugal
2021/03/19 - 2021/03/19 Time management - workshop within the Educational Training Program at School of Medicine - University of Minho, Braga, Portugal.
Workshop
 Transversal Skills and Employability Workshop
Universidade do Minho Escola de Medicina, Portugal
2021/03/13 - 2021/03/13 I Jornadas de Imunoterapia do Alentejo e Algarve
Other
 I Jornadas de Imunoterapia do Alentejo e Algarve
2021/01/21 - 2021/01/21 Preparation for selection interviews - workshop within the Educational Training Program at School of Medicine - University of Minho, Braga, Portugal.
Workshop
 Transversal Skills and Employability Workshop
Universidade do Minho Escola de Medicina, Portugal
2020/09/25 - 2020/09/25 Different thematics of tumor complexity (genetics, biomarkers, tumor microenvironment, tumor metabolism, and new potential therapeutic targets) was addressed, as well as the application of knowledge to improve the diagnosis or treatments of cancer patients.
Other
 WEBINAR: Cancer Biology: From Basic To Translational Research
Liga Portuguesa Contra o Cancro, Portugal
2020/07/14 - 2020/07/14 Discussion about using a variety of 3D techniques/models to bridge the gap between the convenience of conventional 2D models and the biological relevance of animal models.
Other
 ELRIG webinar: 3D Models – An Alternative to or in combination with traditional 2D Assays for Drug Discovery
ELRIG, United Kingdom

Nexcelom Bioscience, United States
2020/06/23 - 2020/06/23 In vitro disease models as important tools for the development of new drugs, serving as low-cost screening platforms for drug therapies.
Other
 3D Cell Culture Models: Challenges and Optimized Assays (Webinar)
Corning Inc, United States

Promega Biotech Ibérica, Spain
2019/10/17 - 2019/10/19 ISCaM 2019 6th Annual meeting CANCER METABOLIC REWIRING: MAPPING THE ROAD TO CLINICAL TRANSLATION
Conference
 ISCaM 2019 6th Annual meeting CANCER METABOLIC REWIRING: MAPPING THE ROAD TO CLINICAL TRANSLATION
Universidade do Minho, Portugal

Universidade do Minho Escola de Ciências, Portugal

Universidade do Minho Escola de Medicina, Portugal

Universidade do Minho Centro de Biologia Molecular e Ambiental, Portugal

Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2019/10/03 - 2019/10/03 How to write great papers and get published. Understanding and benefiting from the publishing process. By Elsevier Researcher Academy.
Workshop
 How to Write a Great Research Paper, and Get it Accepted by a Good Journal
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2019/04 - 2019/04 ICVS Open Day 2019
Meeting
 ICVS Open Day
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2019/01 - 2019/01 Nanotechnology for Therapy and Diagnostics, nanoGateway Winter School 2019
Conference
 Nanotechnology for Therapy and Diagnostics
International Iberian Nanotechnology Laboratory, Portugal
2018/04/06 - 2018/04/06 ICVS Open Day 2018
Meeting
 ICVS Open Day
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2018/04 - 2018/04 25th Porto Cancer meeting 2018 - Cancer Wars: The Immune Force Awakens
Conference
 25th Porto Cancer Meeting 25th Porto Cancer meeting - Cancer Wars: The Immune Force Awakens
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2016 - 2016 3ª Jornada da Oferta Pós-graduada da ECUM "UM Futuro com Ciência"
Conference
 3ª Jornada da Oferta Pós-graduada da ECUM "UM Futuro com Ciência"
Universidade do Minho Escola de Ciências, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2021/04 - 2021/04 III Jornadas da Ciência - Development of 3D culture systems for in vitro study of tumour pathophysiology Universidade do Minho Escola de Ciências, Portugal
2017/10/26 - 2017/10/26 Experimental Approaches in Oncobiology: Lab II Immunohistochemistry method Fundamentals in Genetics, Development and Neoplasia (Curso de mestrado (conclusão do curso de especialização)) Universidade do Minho Escola de Medicina, Portugal

Mentoring / Tutoring

Topic Student name
2023/10 - 2024/05 “The influence of the tumor suppressor gene SPINT2 on melanoma cells’ metabolism” - Laboratory rotation - Medical student Carolina Branzinha
2021 - 2022 "Assessing the in vitro antimicrobial and antitumor activity of Portuguese propolis" - Thesis - Master's student Rafaela Oliveira
2020/11 - 2020/12 “Therapeutic relevance of the tumorsuppressor gene SPINT2 in Melanoma” - Laboratory rotation - Master's student Beatriz Peixoto
2019/11 - 2019/11 "SPINT2 influence in melanoma metabolism" - Laboratory Rotation - Master's student Adriana Faria
2018/12 - 2019 "Microsatellite instability in gastric cancer" - Thesis - PhD student Jean Paul
2018/05 - 2018/05 "Functional role of the tumor suppressor gene SPINT-2 in Melanoma (skin cancer)" - Laboratory Rotation - PhD student Matilde Neto
2017/11 - 2018/01 "Functional role of the tumor suppressor gene SPINT-2 in Melanoma" - Laboratory Rotation-Master's student Inês Fernandes Lages
2017/07 - 2017/09 "Study of the epigenetic silencing of the tumor suppressor gene SPINT2 in lung cancer" - Master thesis - Medical student Bruno Peixoto
2017/07/01 - 2017/07/31 "Functional role of the tumor suppressor gene SPINT-2 in Melanoma" - Laboratory Rotation - Erasmus/Medical student Bertha Elena Arangure
Distinctions

Award

2020 Best poster in Cancer Biology: From Basic To Translational Research 2020 (Webinar)
Liga Portuguesa Contra o Cancro, Portugal
2019 Project winner of the national contest: "Bolsa da Liga Portuguesa Contra o Cancro/ Fundação PT (2018)"
Liga Portuguesa Contra o Cancro, Portugal