Adelaide Fernandes (2F17-4BE1-A074)

Curriculum Vitae

Adelaide Fernandes

Adelaide Fernandes received her degree in Pharmaceutical Sciences in 2002. She performs neuroscience research since 2002. Her PhD studies focused on glia reactivity during neonatal development were performed at the Faculty of Pharmacy of the University of Lisbon (FFULisboa), having received her PhD in 2006, from the University of Lisbon. From 2006 to 2010 she developed post-doctoral studies focused on changed on neuronal development and myelination during early postnatal conditions, at Research Institute for Medicines (iMed.Ulisboa) and Department of Neuroscience, University of Minneapolis. She is Assistant Professor at FFUlisboa since 2011. Adelaide research focuses on neuron-glial interplay during neurodevelopment and neurodegenerative disorders. Adelaide explored the impact of neurodevelopmental disorders (e.g. jaundice, sepsis) on astrogliosis, neurodegeneration and recently on oligodendrogenesis and myelination. Presently, Adelaide focus on neuroinflammation in neurodegenerative disorders, as Multiple Sclerosis and in ageing associated Alzheimer’s disease, namely in inflammatory cross-talk between neurons and glial cells with a particular interest in microglia phenotype, using organotypic cultures, 3D cellular systems derived from induced Pluripotent Stem Cells or animal models of degenerative disorders. Her work granted her a Medal of Honour L’Óreal for Women in Science – L’Óreal/UNESCO/FCT in 2011, an Innovation Research Grant from Portuguese Pharmaceutical Society in 2013, a National-FCT funded project and a Grant for Multiple Sclerosis Innovation by Merck-Serono in 2017, in parallel with funding from other research projects and procurement agreements.

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Identificação

Identificação pessoal

Nome completo: Adelaide Fernandes

Nomes de citação

Fernandes, Adelaide

Identificadores de autor

Ciência ID: 2F17-4BE1-A074
ORCID iD: 0000-0002-2782-9519

Idiomas

Idioma	Conversação	Leitura	Escrita	Compreensão	Peer-review
Inglês	Utilizador proficiente (C1)	Utilizador proficiente (C1)	Utilizador proficiente (C1)	Utilizador proficiente (C1)

Formação

	Grau	Classificação
2006 Concluído	Pharmacy (Doutoramento) Universidade de Lisboa Faculdade de Farmácia, Portugal "Mechanisms of astrocyte inflammatory response to UCB and modulation by immunosuppressive therapy" (TESE/DISSERTAÇÃO)	Unanimous summa cum laude
2002 Concluído	Pharmaceutical Sciences (Licenciatura) Universidade de Lisboa Faculdade de Farmácia, Portugal	16 (dezasseis) valores

Percurso profissional

Ciência

	Categoria Profissional Instituição de acolhimento	Empregador
2015 - Atual	Investigador principal (carreira) (Investigação)	Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal

Docência no Ensino Superior

	Categoria Profissional Instituição de acolhimento	Empregador
2023/07/01 - Atual	Professor Associado (Docente Universitário)	Universidade de Lisboa Faculdade de Farmácia, Portugal
	Universidade de Lisboa Faculdade de Farmácia, Portugal
2010/12/01 - 2023/06/30	Professor Auxiliar (Docente Universitário)	Universidade de Lisboa Faculdade de Farmácia, Portugal
	Universidade de Lisboa Faculdade de Farmácia, Portugal

Outros

	Categoria Profissional Instituição de acolhimento	Empregador
2009/07/01 - 2010/11/30	Research Assistant C2008-FFUL-UBMBE-02-2008, Ciência 2008.	Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal

2006/10/01 - 2009/06/30	Postdoctoral student (SFRH/BPD/26390/2006)	Universidade de Lisboa Faculdade de Farmácia, Portugal

2002/10/01 - 2006/09/30	PhD Student	Universidade de Lisboa Faculdade de Farmácia, Portugal

2002/04/01 - 2002/09/30	Research Fellow	Universidade de Lisboa Faculdade de Farmácia, Portugal

1999/09/01 - 2001/09/30	Trainee student	Universidade de Lisboa Faculdade de Farmácia, Portugal

Projetos

Bolsa

	Designação	Financiadores
2024/01/01 - 2025/12/01	Microbiome manipulation to reduce psychopathology in Multiple Sclerosis BiocodexMicrobiota 2024 Investigador responsável Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Biocodex Microbiota Foundation Em curso
2022/01 - 2024/12	Análise da desregulação neuroimmune na doença de Alzheimer para uma terapia com miRNAs veiculados por exosomas Provided by PTCRIS: PTDC/MED-NEU/2382/2021 Investigador	Fundação para a Ciência e a Tecnologia
2022/01 - 2024/12	A interação entre a resposta imune inata e a adquirida como base do defice cognitivo presente na Esclerose Múltipla Provided by PTCRIS: PTDC/MED-PAT/2582/2021 Investigador responsável	Fundação para a Ciência e a Tecnologia
2022/01 - 2023/12	A interação da microglia e das células T na base da excessiva eliminação de sinapses associada ao défice cognitivo na Esclerose Múltipla 688273478011411110311497109973280698383796547202109209472022DRI Investigador responsável	Fundação para a Ciência e a Tecnologia
2020/01 - 2023/12	Instituto de Investigação do Medicamento Provided by PTCRIS: UIDP/04138/2020 Investigador	Fundação para a Ciência e a Tecnologia
2020/01 - 2023/12	Instituto de Investigação do Medicamento Provided by PTCRIS: UIDB/04138/2020 Investigador	Fundação para a Ciência e a Tecnologia
2022/01 - 2023/06	Papel da obesidade na esclerose múltipla: identificação de microRNAs relacionados com o desenvolvimento dos oligodendrócitos como novos alvos terapêuticos para promover a remielinização Provided by PTCRIS: EXPL/MED-NEU/1033/2021 Investigador	Fundação para a Ciência e a Tecnologia
2022 - 2023	Unraveling the role of glial cells in ARSACS ARSACS2022 Co-Investigador Responsável (Co-IR) Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Ataxia Canada Concluído
2018/10 - 2022/09	Novas Substâncias Psicoativas, Cérebro e Adolescência - Uma Plataforma de Avaliação de Risco Provided by PTCRIS: PTDC/SAU-TOX/32515/2017 Investigador	Fundação para a Ciência e a Tecnologia
2018/09 - 2022/08	Detetar, prevenir, erradicar: uma estratégia concertada para combater a metastização do cancro da mama para o encéfalo Provided by PTCRIS: PTDC/MED-ONC/29402/2017 Investigador	Fundação para a Ciência e a Tecnologia
2018/08 - 2022/08	Desenvolvimento de uma terapia para uso de exosomas autólogos após modulação de microRNAs em microglia e neurónios-motores recorrendo a modelos animais e humanos de esclerose lateral amiotrófica ELA Provided by PTCRIS: PTDC/MED-NEU/31395/2017 Investigador	Fundação para a Ciência e a Tecnologia
2018/07/01 - 2021/06/30	Targeting multiple sclerosis immune- and psycho-pathophysiology by modulation of neuroinflammation GMSI2017 Investigador responsável Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Merck KGaA Em curso
2019/01 - 2019/12	Instituto de Investigação do Medicamento Provided by PTCRIS: UID/DTP/04138/2019 Investigador	Fundação para a Ciência e a Tecnologia
2018/09 - 2019/09	New molecules to characterize & treat demyelinating lesions - MyelinBASHY YiMed-2018 Investigador responsável Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Concluído
2016/01 - 2019/06	Geração de modelos celulares e animais aperfeiçoados para identificação do fenótipo e de novos alvos terapêuticos na Doença de Alzheimer Provided by PTCRIS: JPCOFUND/0003/2015 Investigador	Fundação para a Ciência e a Tecnologia
2017 - 2019	Identification and assessment of new psychoactive substances: a European network - co-funded by the European Union HOME/2014/JDRU/AG/DRUG/7086 Investigador Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Concluído
2015/01 - 2018/12	Instituto de Investigação do Medicamento Provided by PTCRIS: UID/DTP/04138/2013 Investigador	Fundação para a Ciência e a Tecnologia
2015 - 2018	Development of a European network for preclinical testing of interventions in mouse models of age and age-related diseases (MouseAGE) COST Action BM1402 Investigador Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Concluído
2014/03 - 2015/08	Decrifrar como os microRNAs regulam o fenótipo da microglia na Doença de Alzheimer Provided by PTCRIS: EXPL/NEU-NMC/1003/2013 Investigador	Fundação para a Ciência e a Tecnologia
2012/01 - 2015/07	SERÁ A MICROGLIA UM NOVO ALVO FARMACOLÓGICO COM POTENCIAL INTERESSE NA ESCLEROSE LATERAL AMIOTRÓFICA ELA? Provided by PTCRIS: PTDC/SAU-FAR/118787/2010 Investigador	Fundação para a Ciência e a Tecnologia
2014/03 - 2015/02	Decoding the regulation of microglia phenotype by microRNAs in Alzheimer's Disease 134028 Provided by PTCRIS: 134028 Investigador responsável	Fundação para a Ciência e a Tecnologia, I.P.
2014/02 - 2014/09	LisbonLiving+: Innovative strategies for a healthy life and an active ageing in the Region of Lisbon Provided by PTCRIS: 135837 135837 Investigador	Fundação para a Ciência e a Tecnologia, I.P.
2013/10 - 2014/09	Role of S100B in multiple sclerosis: from a biomarker to a therapeutic target Ordem Farmaceuticos2013 Investigador responsável Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Ordem dos Farmaceuticos Concluído
2011/01 - 2013/12	Projecto Estratégico - UI 4013 - 2011-2012 123298UID Investigador	Fundação para a Ciência e a Tecnologia
2007/07 - 2011/04	Estudo da perturbação da barreira hemato-encefálica por neurotoxinas e modulação por agentes terapêuticos num modelo humano: efeitos da bilirrubina e da endotoxina em células endoteliais de capilares cerebrais e acção protectora de ácidos biliares Provided by PTCRIS: PTDC/SAU-FCF/68819/2006 Investigador	Fundação para a Ciência e a Tecnologia
2007/07 - 2010/12	À descoberta de potenciais alterações de neurodesenvolvimento em situações comuns no período neonatal, tais como na hiperbilirrubinemia e na inflamação Provided by PTCRIS: PTDC/SAU-NEU/64385/2006 64385 Provided by PTCRIS: 64385 Investigador	Fundação para a Ciência e a Tecnologia Fundação para a Ciência e a Tecnologia, I.P.
2007/01 - 2009/07	Acute and long-term injury of bilirubin to nerve cells - Looking for sensors, susceptibilities and modulators Provided by PTCRIS: 82303 82303 Investigador	Fundação para a Ciência e a Tecnologia, I.P.
2006/10 - 2009/06	MODULATION OF GROWTH CONE BEHAVIOR AND AXONAL CONNECTIONS FORMATION IN DEVELOPING NERVOUS SYSTEM BY TOXICANTS POTENTIALLY RELATED WITH SCHIZOPHRENIA Provided by PTCRIS: SFRH/BPD/26390/2006 Bolseiro de Pós-Doutoramento	Fundação para a Ciência e a Tecnologia
2005/09 - 2008/06	Lesão cerebral pela bilirrubina e impacto nas doenças neurodegenerativas - À procura de sensores, susceptilidades e moduladores Provided by PTCRIS: POCI/SAU-MMO/55955/2004 Bolseiro de Doutoramento	Fundação para a Ciência e a Tecnologia
2002/10 - 2006/09	RESPOSTA INFLAMATÓRIA DAS CÉLULAS NERVOSAS A AGENTES NEUROTÓXICOS COMO A BILIRRUBINA, A ENDOTOXINA E A AMÓNIA. MODULAÇÃO PELA VITAMINA-E E IL-10 Provided by PTCRIS: SFRH/BD/9204/2002 Bolseiro de Doutoramento	Fundação para a Ciência e a Tecnologia

Projeto

	Designação	Financiadores
2023/07/01 - 2028/06/30	SIMPATHIC - Accelerating drug repurposing for rare neurological, neurometabolic and neuromuscular disorders by exploiting SIMilarities in clinical and molecular PATHology SYMPATHIC Investigador Universidade de Lisboa Faculdade de Farmácia, Portugal	European Research Executive Agency Em curso
2015 - 2016	Evaluation of the impact of ingredients on myelination markers in an ex vivo cerebellar slice culture mode Nestle2014 Investigador responsável Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Nestlé Lausanne Concluído

Produções

Publicações

Artigo em revista

Barateiro, A.; Barros, C.; Pinto, M.V.; Ribeiro, A.R.; Alberro, A.; Fernandes, A.. "Women in the field of multiple sclerosis: How they contributed to paradigm shifts". Frontiers in Molecular Neuroscience 16 (2023): http://www.scopus.com/inward/record.url?eid=2-s2.0-85148413021&partnerID=MN8TOARS.
10.3389/fnmol.2023.1087745
Neto, A.; Fernandes, A.; Barateiro, A.. "The complex relationship between obesity and neurodegenerative diseases: an updated review". Frontiers in Cellular Neuroscience 17 (2023): http://www.scopus.com/inward/record.url?eid=2-s2.0-85177635639&partnerID=MN8TOARS.
10.3389/fncel.2023.1294420
Gonçalo Garcia; Sara Pinto; Sofia Ferreira; Daniela Lopes; Maria João Serrador; Adelaide Fernandes; Ana Rita Vaz; et al. "Emerging Role of miR-21-5p in Neuron–Glia Dysregulation and Exosome Transfer Using Multiple Models of Alzheimer’s Disease". Cells (2022): https://doi.org/10.3390/cells11213377.
10.3390/cells11213377
Catarina Barros; Andreia Barateiro; Alexandre Neto; Beatriz Soromenho; Afonso P. Basto; Joana M. Mateus; Sara Xapelli; et al. "S100B inhibition protects from chronic experimental autoimmune encephalomyelitis". Brain Communications (2022): https://doi.org/10.1093/braincomms/fcac076.
10.1093/braincomms/fcac076
Ana Rita Ribeiro; Catarina Barros; Andreia Barateiro; Susan E Howlett; Adelaide Fernandes; David Le Couteur. "Improved Assessment of Overall Health in Variably Aged Murine Models of Multiple Sclerosis With a Novel Frailty Index Tool". The Journals of Gerontology: Series A (2022): https://doi.org/10.1093/gerona/glab185.
10.1093/gerona/glab185
Adelaide Fernandes; Cláudia Caldeira; Carolina Cunha; Elisabete Ferreiro; Ana Rita Vaz; Dora Brites. "Differences in Immune-Related Genes Underlie Temporal and Regional Pathological Progression in 3xTg-AD Mice". Cells (2022): https://doi.org/10.3390/cells11010137.
10.3390/cells11010137
Garcia, G.; Fernandes, A.; Stein, F.; Brites, D.. "Protective Signature of IFN¿-Stimulated Microglia Relies on miR-124-3p Regulation From the Secretome Released by Mutant APP Swedish Neuronal Cells". Frontiers in Pharmacology 13 (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85130760459&partnerID=MN8TOARS.
10.3389/fphar.2022.833066
Acúrcio, R.C.; Pozzi, S.; Carreira, B.; Pojo, M.; Gómez-Cebrián, N.; Casimiro, S.; Fernandes, A.; et al. "Therapeutic targeting of PD-1/PD-L1 blockade by novel small-molecule inhibitors recruits cytotoxic T cells into solid tumor microenvironment". Journal for ImmunoTherapy of Cancer 10 7 (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85134789748&partnerID=MN8TOARS.
10.1136/jitc-2022-004695
Maria V. Pinto; Fábio M. F. Santos; Catarina Barros; Ana Rita Ribeiro; Uwe Pischel; Pedro M. P. Gois; Adelaide Fernandes. "BASHY Dye Platform Enables the Fluorescence Bioimaging of Myelin Debris Phagocytosis by Microglia during Demyelination". Cells 10 11 (2021): 3163-3163. https://doi.org/10.3390/cells10113163.
10.3390/cells10113163
Gonçalo Garcia; Sara Pinto; Mar Cunha; Adelaide Fernandes; Jari Koistinaho; Dora Brites. "Neuronal Dynamics and miRNA Signaling Differ between SH-SY5Y APPSwe and PSEN1 Mutant iPSC-Derived AD Models upon Modulation with miR-124 Mimic and Inhibitor". Cells 10 9 (2021): 2424-2424. https://doi.org/10.3390/cells10092424.
10.3390/cells10092424
Ainhoa Alberro; Leire Iparraguirre; Adelaide Fernandes; David Otaegui. "Extracellular Vesicles in Blood: Sources, Effects, and Applications". International Journal of Molecular Sciences 22 15 (2021): 8163-8163. https://doi.org/10.3390/ijms22158163.
10.3390/ijms22158163
Maria J. S. A. Silva; Hélio Faustino; Jaime A. S. Coelho; Maria V. Pinto; Adelaide Fernandes; Ismael Compañón; Francisco Corzana; et al. "Efficient Amino-Sulfhydryl Stapling on Peptides and Proteins Using Bifunctional NHS-Activated Acrylamides". Angewandte Chemie 60 19 (2021): 10850-10857. https://doi.org/10.1002/ange.202016936.
10.1002/ange.202016936
Barros, C.; Fernandes, A.. "Linking Cognitive Impairment to Neuroinflammation in Multiple Sclerosis using neuroimaging tools". Multiple Sclerosis and Related Disorders 47 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85096671779&partnerID=MN8TOARS.
10.1016/j.msard.2020.102622
Momtazmanesh, S.; Shobeiri, P.; Saghazadeh, A.; Teunissen, C.E.; Burman, J.; Szalardy, L.; Klivenyi, P.; et al. "Neuronal and glial CSF biomarkers in multiple sclerosis: A systematic review and meta-analysis". Reviews in the Neurosciences (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85101030060&partnerID=MN8TOARS.
10.1515/revneuro-2020-0145
Maria V. Pinto; Adelaide Fernandes. "Microglial Phagocytosis—Rational but Challenging Therapeutic Target in Multiple Sclerosis". International Journal of Molecular Sciences (2020): https://doi.org/10.3390/ijms21175960.
10.3390/ijms21175960
Ribeiro, A.R.; Howlett, S.E.; Fernandes, A.. "Frailty—A promising concept to evaluate disease vulnerability". Mechanisms of Ageing and Development 187 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85080084499&partnerID=MN8TOARS.
10.1016/j.mad.2020.111217
das Neves, S.P.; Santos, G.; Barros, C.; Pereira, D.R.; Ferreira, R.; Mota, C.; Monteiro, S.; et al. "Enhanced cognitive performance in experimental autoimmune encephalomyelitis mice treated with dimethyl fumarate after the appearance of disease symptoms". Journal of Neuroimmunology 340 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85078129302&partnerID=MN8TOARS.
10.1016/j.jneuroim.2020.577163
Santos, F.M.F.; Domínguez, Z.; Fernandes, J.P.L.; Parente Carvalho, C.; Collado, D.; Pérez-Inestrosa, E.; Pinto, M.V.; et al. "Cyanine-Like Boronic Acid-Derived Salicylidenehydrazone Complexes (Cy-BASHY) for Bioimaging Applications". Chemistry - A European Journal 26 62 (2020): 14064-14069. http://www.scopus.com/inward/record.url?eid=2-s2.0-85091763359&partnerID=MN8TOARS.
10.1002/chem.202001623
Santos, G.; Barateiro, A.; Brites, D.; Fernandes, A.. "S100B Impairs Oligodendrogenesis and Myelin Repair Following Demyelination Through RAGE Engagement". Frontiers in Cellular Neuroscience 14 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85091209245&partnerID=MN8TOARS.
10.3389/fncel.2020.00279
de Mello-Sampayo, C.; Vaz, A.R.; Henriques, S.C.; Fernandes, A.; Paradinha, F.; Florindo, P.; Faria, P.; et al. "Designer Cathinones N-Ethylhexedrone and Buphedrone Show Different In Vitro Neurotoxicity and Mice Behaviour Impairment". Neurotoxicity Research (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85086428280&partnerID=MN8TOARS.
10.1007/s12640-020-00229-6
Rocha, J.; Leandro, R.; Direito, R.; Gonçalves, M.; Duarte, M.P.; Fernandes, A.; Sepodes, B.; Figueira, M.-E.. "Attenuation of colonic injury and inflammation by administration of a phenolic extract of summer savory (Satureja hortensis l.) in experimental inflammatory bowel disease in mice". Applied Sciences (Switzerland) 10 23 (2020): 1-19. http://www.scopus.com/inward/record.url?eid=2-s2.0-85096646571&partnerID=MN8TOARS.
10.3390/app10238465
Rosa Direito; João Rocha; Ana-Teresa Serra; Adelaide Fernandes; Marisa Freitas; Eduarda Fernandes; Rui Pinto; et al. "Anti-inflammatory Effects of Persimmon (Diospyros kaki L.) in Experimental Rodent Rheumatoid Arthritis". Journal of Dietary Supplements (2019): https://doi.org/10.1080/19390211.2019.1645256.
10.1080/19390211.2019.1645256
João Rocha; Ana Lima; Maria Margarida Gonçalves; Maria Paula Duarte; Vanessa Mateus; Catarina Sousa; Fernandes A; et al. "Reduction of Inflammation and Colon Injury by a Spearmint Phenolic Extract in Experimental Bowel Disease in Mice". Medicines (2019): https://www.mdpi.com/2305-6320/6/2/65.
10.3390/medicines6020065
Markus Schosserer; Gareth Banks; Soner Dogan; Peter Dungel; Adelaide Fernandes; Darja Marolt Presen; Ander Matheu; et al. "Modelling physical resilience in ageing mice". Mechanisms of Ageing and Development 177 (2019): 91-102. https://doi.org/10.1016/j.mad.2018.10.001.
10.1016/j.mad.2018.10.001
Mendes, C.; Rocha, J.; Direito, R.; Fernandes, A.; Sepodes, B.; Figueira, M.-E.; Ribeiro, M.H.. "Anti-inflammatory activity of grapefruit juice in an in vivo model of ulcerative colitis: Comparability studies of unprocessed and bioprocessed juices". Journal of Functional Foods 63 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85072299230&partnerID=MN8TOARS.
10.1016/j.jff.2019.103564
Rocha, J.; Direito, R.; Lima, A.; Mota, J.; Gonçalves, M.; Duarte, M.P.; Solas, J.; et al. "Reduction of inflammation and colon injury by a Pennyroyal phenolic extract in experimental inflammatory bowel disease in mice". Biomedicine and Pharmacotherapy 118 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85070874907&partnerID=MN8TOARS.
10.1016/j.biopha.2019.109351
Ana Luisa Cardoso; Adelaide Fernandes; Juan Antonio Aguilar-Pimentel; Martin Hrabe de Angelis; Joana Ribeiro Guedes; Maria Alexandra Brito; Saida Ortolano; et al. "Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases". Ageing Research Reviews 47 (2018): 214-277. https://doi.org/10.1016/j.arr.2018.07.004.
10.1016/j.arr.2018.07.004
Cunha, C.; Santos, C.; Gomes, C.; Fernandes, A.; Correia, A.M.; Sebastião, A.M.; Vaz, A.R.; Brites, D.. "Downregulated Glia Interplay and Increased miRNA-155 as Promising Markers to Track ALS at an Early Stage". Molecular Neurobiology 55 5 (2018): 4207-4224. http://www.scopus.com/inward/record.url?eid=2-s2.0-85020723635&partnerID=MN8TOARS.
10.1007/s12035-017-0631-2
Santos, G.; Barateiro, A.; Gomes, C.M.; Brites, D.; Fernandes, A.. "Impaired oligodendrogenesis and myelination by elevated S100B levels during neurodevelopment". Neuropharmacology 129 (2018): 69-83. http://www.scopus.com/inward/record.url?eid=2-s2.0-85034070602&partnerID=MN8TOARS.
10.1016/j.neuropharm.2017.11.002
Fernandes, A.; Ribeiro, A.R.; Monteiro, M.; Garcia, G.; Vaz, A.R.; Brites, D.. "Secretome from SH-SY5Y APPSwecells trigger time-dependent CHME3 microglia activation phenotypes, ultimately leading to miR-21 exosome shuttling". Biochimie (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85048597442&partnerID=MN8TOARS.
10.1016/j.biochi.2018.05.015
Direito, R.; Lima, A.; Rocha, J.; Ferreira, R.B.; Mota, J.; Rebelo, P.; Fernandes, A.; et al. "Dyospiros kaki phenolics inhibit colitis and colon cancer cell proliferation, but not gelatinase activities". Journal of Nutritional Biochemistry 46 (2017): 100-108. http://www.scopus.com/inward/record.url?eid=2-s2.0-85018410246&partnerID=MN8TOARS.
10.1016/j.jnutbio.2017.03.002
Caldeira, C.; Cunha, C.; Vaz, A.R.; Falcão, A.S.; Barateiro, A.; Seixas, E.; Fernandes, A.; Brites, D.. "Key aging-associated alterations in primary microglia response to beta-amyloid stimulation". Frontiers in Aging Neuroscience 9 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85030703999&partnerID=MN8TOARS.
Barateiro, A.; Afonso, V.; Santos, G.; Cerqueira, J.J.; Brites, D.; van Horssen, J.; Fernandes, A.. "S100B as a Potential Biomarker and Therapeutic Target in Multiple Sclerosis". Molecular Neurobiology 53 6 (2016): 3976-3991. http://www.scopus.com/inward/record.url?eid=2-s2.0-84937132572&partnerID=MN8TOARS.
10.1007/s12035-015-9336-6
Figueira, I.; Fernandes, A.; Mladenovic Djordjevic, A.; Lopez-Contreras, A.; Henriques, C.M.; Selman, C.; Ferreiro, E.; et al. "Interventions for age-related diseases: Shifting the paradigm". Mechanisms of Ageing and Development 160 (2016): 69-92. http://www.scopus.com/inward/record.url?eid=2-s2.0-84999035290&partnerID=MN8TOARS.
10.1016/j.mad.2016.09.009
Figueira, M.-E.; Oliveira, M.; Direito, R.; Rocha, J.; Alves, P.; Serra, A.-T.; Duarte, C.; et al. "Protective effects of a blueberry extract in acute inflammation and collagen-induced arthritis in the rat". Biomedicine and Pharmacotherapy 83 (2016): 1191-1202. http://www.scopus.com/inward/record.url?eid=2-s2.0-84989266756&partnerID=MN8TOARS.
10.1016/j.biopha.2016.08.040
Barateiro, A.; Brites, D.; Fernandes, A.. "Oligodendrocyte development and myelination in neurodevelopment: Molecular mechanisms in health and disease". Current Pharmaceutical Design 22 6 (2016): 656-679. http://www.scopus.com/inward/record.url?eid=2-s2.0-84958232730&partnerID=MN8TOARS.
10.2174/1381612822666151204000636
Barateiro, A.; Chen, S.; Yueh, M.-F.; Fernandes, A.; Domingues, H.S.; Relvas, J.; Barbier, O.; et al. "Reduced myelination and increased glia reactivity resulting from severe neonatal hyperbilirubinemia". Molecular Pharmacology 89 1 (2016): 84-93. http://www.scopus.com/inward/record.url?eid=2-s2.0-84958151344&partnerID=MN8TOARS.
10.1124/mol.115.098228
Silva, S.; Sepodes, B.; Rocha, J.; Direito, R.; Fernandes, A.; Brites, D.; Freitas, M.; et al. "Protective effects of hydroxytyrosol-supplemented refined olive oil in animal models of acute inflammation and rheumatoid arthritis". Journal of Nutritional Biochemistry 26 4 (2015): 360-368. http://www.scopus.com/inward/record.url?eid=2-s2.0-84925341472&partnerID=MN8TOARS.
10.1016/j.jnutbio.2014.11.011
Rocha, J.; Figueira, M.-E.; Barateiro, A.; Fernandes, A.; Brites, D.; Pinto, R.; Freitas, M.; et al. "Inhibition of glycogen synthase kinase-3ß attenuates organ injury and dysfunction associated with liver ischemia-reperfusion and thermal injury in the rat". Shock 43 4 (2015): 369-378. http://www.scopus.com/inward/record.url?eid=2-s2.0-84924905290&partnerID=MN8TOARS.
10.1097/SHK.0000000000000298
Vila-Real, H.; Coelho, H.; Rocha, J.; Fernandes, A.; Ventura, M.R.; Maycock, C.D.; Iranzo, O.; Simplício, A.L.. "Peptidomimetic ß-Secretase Inhibitors Comprising a Sequence of Amyloid-ß Peptide for Alzheimer's Disease". Journal of Medicinal Chemistry 58 14 (2015): 5408-5418. http://www.scopus.com/inward/record.url?eid=2-s2.0-84937675445&partnerID=MN8TOARS.
10.1021/acs.jmedchem.5b00658
Brites, D.; Fernandes, A.. "Bilirubin-induced neural impairment: A special focus on myelination, age-related windows of susceptibility and associated co-morbidities". Seminars in Fetal and Neonatal Medicine 20 1 (2015): 14-19. http://www.scopus.com/inward/record.url?eid=2-s2.0-84922931419&partnerID=MN8TOARS.
10.1016/j.siny.2014.12.002
Cardoso, F.L.; Herz, J.; Fernandes, A.; Rocha, J.; Sepodes, B.; Brito, M.A.; McGavern, D.B.; Brites, D.. "Systemic inflammation in early neonatal mice induces transient and lasting neurodegenerative effects". Journal of Neuroinflammation 12 1 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84929431467&partnerID=MN8TOARS.
10.1186/s12974-015-0299-3
Rocha, J.; Eduardo-Figueira, M.; Barateiro, A.; Fernandes, A.; Brites, D.; Bronze, R.; Duarte, C.M.; et al. "Anti-inflammatory effect of rosmarinic acid and an extract of rosmarinus officinalis in rat models of local and systemic inflammation". Basic and Clinical Pharmacology and Toxicology 116 5 (2015): 398-413. http://www.scopus.com/inward/record.url?eid=2-s2.0-84926358222&partnerID=MN8TOARS.
10.1111/bcpt.12335
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10.3109/10837450.2014.915571
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10.1016/j.biomag.2014.07.005
Barateiro, A.; Domingues, H.S.; Fernandes, A.; Relvas, J.B.; Brites, D.. "Rat cerebellar slice cultures exposed to bilirubin evidence reactive gliosis, excitotoxicity and impaired myelinogenesis that is prevented by AMPA and TNF-a inhibitors". Molecular Neurobiology 49 1 (2014): 424-439. http://www.scopus.com/inward/record.url?eid=2-s2.0-84894373448&partnerID=MN8TOARS.
10.1007/s12035-013-8530-7
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10.3389/fncel.2014.00152
Falcão, A.S.; Silva, R.F.M.; Vaz, A.R.; Gomes, C.; Fernandes, A.; Barateiro, A.; Tiribelli, C.; Brites, D.; Silva, S.L.. "Cross-talk between neurons and astrocytes in response to bilirubin: Adverse secondary impacts". Neurotoxicity Research 26 1 (2014): 1-15. http://www.scopus.com/inward/record.url?eid=2-s2.0-84903741375&partnerID=MN8TOARS.
10.1007/s12640-013-9427-y
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10.1007/s00441-012-1529-y
Barateiro, A.; Miron, V.E.; Santos, S.D.; Relvas, J.B.; Fernandes, A.; Ffrench-Constant, C.; Brites, D.. "Unconjugated bilirubin restricts oligodendrocyte differentiation and axonal myelination.". Molecular neurobiology 47 2 (2013): 632-644. http://www.scopus.com/inward/record.url?eid=2-s2.0-84894303554&partnerID=MN8TOARS.
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10.1016/j.neuropharm.2012.02.002
Barateiro, A.; Vaz, A.R.; Silva, S.L.; Fernandes, A.; Brites, D.. "ER stress, mitochondrial dysfunction and calpain/jnk activation are involved in oligodendrocyte precursor cell death by unconjugated bilirubin". NeuroMolecular Medicine 14 4 (2012): 285-302. http://www.scopus.com/inward/record.url?eid=2-s2.0-84870563054&partnerID=MN8TOARS.
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Barateiro, A.; Miron, V.E.; Santos, S.D.; Relvas, J.B.; Fernandes, A.; ffrench-Constant, C.; Brites, D.. "Unconjugated Bilirubin Restricts Oligodendrocyte Differentiation and Axonal Myelination". Molecular Neurobiology (2012): 1-13. http://www.scopus.com/inward/record.url?eid=2-s2.0-84867505724&partnerID=MN8TOARS.
10.1007/s12035-012-8364-8
Vaz, A.R.; Silva, S.L.; Barateiro, A.; Falcão, A.S.; Fernandes, A.; Brito, M.A.; Brites, D.. "Selective vulnerability of rat brain regions to unconjugated bilirubin". Molecular and Cellular Neuroscience 48 1 (2011): 82-93. http://www.scopus.com/inward/record.url?eid=2-s2.0-79960929537&partnerID=MN8TOARS.
10.1016/j.mcn.2011.06.008
Vaz, A.R.; Silva, S.L.; Barateiro, A.; Fernandes, A.; Falcão, A.S.; Brito, M.A.; Brites, D.. "Pro-inflammatory cytokines intensify the activation of NO/NOS, JNK1/2 and caspase cascades in immature neurons exposed to elevated levels of unconjugated bilirubin". Experimental Neurology 229 2 (2011): 381-390. http://www.scopus.com/inward/record.url?eid=2-s2.0-79956137679&partnerID=MN8TOARS.
10.1016/j.expneurol.2011.03.004
Fernandes, A.; Barateiro, A.; Falcão, A.S.; Silva, S.L.-A.; Vaz, A.R.; Brito, M.A.; Marques Silva, R.F.; Brites, D.. "Astrocyte reactivity to unconjugated bilirubin requires TNF-a and IL-1ß receptor signaling pathways". GLIA 59 1 (2011): 14-25. http://www.scopus.com/inward/record.url?eid=2-s2.0-78349235777&partnerID=MN8TOARS.
10.1002/glia.21072
Mariano, C.; Silva, S.L.; Pereira, P.; Fernandes, A.; Brites, D.; Brito, M.A.. "Evidence of tricellulin expression by immune cells, particularly microglia". Biochemical and Biophysical Research Communications 409 4 (2011): 799-802. http://www.scopus.com/inward/record.url?eid=2-s2.0-79959261876&partnerID=MN8TOARS.
10.1016/j.bbrc.2011.05.093
Palmela, I.; Cardoso, F.L.; Bernas, M.; Correia, L.; Vaz, A.R.; Silva, R.F.M.; Fernandes, A.; et al. "Elevated levels of bilirubin and long-term exposure impair human brain microvascular endothelial cell integrity". Current Neurovascular Research 8 2 (2011): 153-169. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955733304&partnerID=MN8TOARS.
10.2174/156720211795495358
Silva, S.L.; Vaz, A.R.; Barateiro, A.; Falcão, A.S.; Fernandes, A.; Brito, M.A.; Silva, R.F.M.; Brites, D.. "Features of bilirubin-induced reactive microglia: From phagocytosis to inflammation". Neurobiology of Disease 40 3 (2010): 663-675. http://www.scopus.com/inward/record.url?eid=2-s2.0-77957807564&partnerID=MN8TOARS.
10.1016/j.nbd.2010.08.010
Brito, M.A.; Vaz, A.R.; Silva, S.L.; Falcão, A.S.; Fernandes, A.; Silva, R.F.M.; Brites, D.. "N-methyl-D-aspartate receptor and neuronal nitric oxide synthase activation mediate bilirubin-induced neurotoxicity". Molecular Medicine 16 9-10 (2010): 372-380. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956632156&partnerID=MN8TOARS.
10.2119/molmed.2009.00152
Brites, D.; Fernandes, A.; Falcão, A.S.; Gordo, A.C.; Silva, R.F.M.; Brito, M.A.. "Biological risks for neurological abnormalities associated with hyperbilirubinemia". Journal of Perinatology 29 (2009): S8-S13. http://www.scopus.com/inward/record.url?eid=2-s2.0-59549101479&partnerID=MN8TOARS.
10.1038/jp.2008.214
Fernandes, A.; Falcão, A.S.; Abranches, E.; Bekman, E.; Henrique, D.; Lanier, L.M.; Brites, D.. "Bilirubin as a determinant for altered neurogenesis, neuritogenesis, and synaptogenesis". Developmental Neurobiology 69 9 (2009): 568-582. http://www.scopus.com/inward/record.url?eid=2-s2.0-67749127695&partnerID=MN8TOARS.
10.1002/dneu.20727
Fernandes, A.; Brites, D.. "Contribution of inflammatory processes to nerve cell toxicity by bilirubin and efficacy of potential therapeutic agents". Current Pharmaceutical Design 15 25 (2009): 2915-2926. http://www.scopus.com/inward/record.url?eid=2-s2.0-70449389923&partnerID=MN8TOARS.
10.2174/138161209789058165
Popko, J.; Fernandes, A.; Brites, D.; Lanier, L.M.. "Automated analysis of neuronj tracing data". Cytometry Part A 75 4 (2009): 371-376. http://www.scopus.com/inward/record.url?eid=2-s2.0-65549113129&partnerID=MN8TOARS.
10.1002/cyto.a.20660
Brito, M.A.; Lima, S.; Fernandes, A.; Falcão, A.S.; Silva, R.F.M.; Butterfield, D.A.; Brites, D.. "Bilirubin injury to neurons: Contribution of oxidative stress and rescue by glycoursodeoxycholic acid". NeuroToxicology 29 2 (2008): 259-269. http://www.scopus.com/inward/record.url?eid=2-s2.0-39749156518&partnerID=MN8TOARS.
10.1016/j.neuro.2007.11.002
Brito, M.A.; Rosa, A.I.; Falcão, A.S.; Fernandes, A.; Silva, R.F.M.; Butterfield, D.A.; Brites, D.. "Unconjugated bilirubin differentially affects the redox status of neuronal and astroglial cells". Neurobiology of Disease 29 1 (2008): 30-40. http://www.scopus.com/inward/record.url?eid=2-s2.0-36549090063&partnerID=MN8TOARS.
10.1016/j.nbd.2007.07.023
Falcão, A.S.; Bellarosa, C.; Fernandes, A.; Brito, M.A.; Silva, R.F.M.; Tiribelli, C.; Brites, D.. "Role of multidrug resistance-associated protein 1 expression in the in vitro susceptibility of rat nerve cell to unconjugated bilirubin". Neuroscience 144 3 (2007): 878-888. http://www.scopus.com/inward/record.url?eid=2-s2.0-33845899686&partnerID=MN8TOARS.
10.1016/j.neuroscience.2006.10.026
Fernandes, A.; Vaz, A.R.; Falcão, A.S.; Silva, R.F.M.; Brito, M.A.; Brites, D.. "Glycoursodeoxycholic acid and interleukin-10 modulate the reactivity of rat cortical astrocytes to unconjugated bilirubin". Journal of Neuropathology and Experimental Neurology 66 9 (2007): 789-798. http://www.scopus.com/inward/record.url?eid=2-s2.0-34548454884&partnerID=MN8TOARS.
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Falcão, A.S.; Silva, R.F.M.; Pancadas, S.; Fernandes, A.; Brito, M.A.; Brites, D.. "Apoptosis and impairment of neurite network by short exposure of immature rat cortical neurons to unconjugated bilirubin increase with cell differentiation and are additionally enhanced by an inflammatory stimulus". Journal of Neuroscience Research 85 6 (2007): 1229-1239. http://www.scopus.com/inward/record.url?eid=2-s2.0-34248141645&partnerID=MN8TOARS.
10.1002/jnr.21227
Fernandes, A.; Falcão, A.S.; Silva, R.F.M.; Brito, M.A.; Brites, D.. "MAPKs are key players in mediating cytokine release and cell death induced by unconjugated bilirubin in cultured rat cortical astrocytes". European Journal of Neuroscience 25 4 (2007): 1058-1068. http://www.scopus.com/inward/record.url?eid=2-s2.0-33847203682&partnerID=MN8TOARS.
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10.1016/j.jneuroim.2004.04.007

Capítulo de livro

Fernandes, Adelaide; Barateiro, A.; Afonso, V.; Brites, D.; Santos, G.; Fernandes, A.. "Role of S100B on Oligodendrocyte Physiology and Pathology.". In Oligodendrocytes: Biology, Functions and Role in the Pathology of Diseases. Nova Science Publishers, 2015.
Publicado • 10.1002/9781634638722.ch5
Fernandes, Adelaide; Vaz, A.R.; Brites, D.. "S100b as a candidate biomarker and therapeutic target in neurodegenerative disorders.". In S100B: Serum Detection, Functions and Clinical Significance. Nova Science Publishers, 2015.
Publicado

Outros

Outra produção

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10.1101/2023.04.24.538087

Atividades

Apresentação oral de trabalho

	Título da apresentação	Nome do evento Anfitrião (Local do evento)
2023/12/01	Participar de Corpo Inteiro	18º Congresso Nacional de Esclerose Multipla SPEM (Evora, Portugal)
2023/06/26	Exploring the impact and CD8 T cells interplay in Multiple Sclerosis	14th iMed.ULisboa Postgraduate Students Meeting iMed (Lisboa, Portugal)
2023/05/01	Microglia and T cells: the dark side of cognitive impairment in multiple sclerosis	European Neuroscience Conference by Doctoral Students (ENCODS 2023) ENCODS (Faro, Portugal)
2022/12/03	O que significa Atrasar a EM?	17ª edição do Congresso Nacional da Esclerose Múltipla (CNEM) SPEM (Lisboa, Portugal)
2022/10/18	Alterations in CNS Pathogenesis of the In Vivo Model of Multiple Sclerosis: Age Impact.	VI Symposium of the Portuguese Glial Network (Porto, Portugal)
2022/07/05	The impact of age in the in vivo model of Multiple Sclerosis: insights in overall health, spinal cord pathology and gut microbiome.	13th iMed.ULisboa Posgraduate Students Meeting (Lisboa, Portugal)
2022/02/11	The impact of age in the glial-immune interplay using the in vivo model of Multiple Sclerosis	52nd Meeting of the Portuguese Society of Pharmacology/40th Clinical Pharmacological Meeting/21st Toxicology Meeting Portuguese Society of Pharmacology (Porto, Portugal)
2021/02/19	THE CELLULAR PLAYERS INTERVENING IN CEREBRAL ISCHEMIA-REPERFUSION INJURY ASSOCIATED WITH STROKE	Sociedade Portuguesa de Farmacologia - Annual Meeting 2021 Sociedade Portuguesa de Farmacologia (Lisbon, Portugal)
2021/02/19	A NEW PHARMACOLOGICAL APPROACH TO PREVENT SYNAPTIC LOSS AND PROMOTE MYELIN PHAGOCYTOSIS: A STEP FORWARD TO MODULATE COGNITIVE IMPAIRMENT AND REMYELINATION IN MS	Sociedade Portuguesa de Farmacologia - Annual Meeting 2021 Sociedade Portuguesa de Farmacologia (Lisbon, Portugal)
2021/02/19	PENTAMIDINE PREVENTS MULTIPLE SCLEROSISLIKE PATHOGENESIS BY NEUTRALIZING S100B TOXIC EFFECTS	Sociedade Portuguesa de Farmacologia - Annual Meeting 2021 Sociedade Portuguesa de Farmacologia (Lisbon, Portugal)
2021/02/19	IMPROVED FRAILTY INDEX SCALE IN IN VIVO MODEL OF MULTIPLE SCLEROSIS: A NOVEL APPROACH TO BETTER UNDERSTAND PHENOTYPIC ALTERATIONS IN DISTINCT MICE- AGED	Sociedade Portuguesa de Farmacologia - Annual Meeting 2021 Sociedade Portuguesa de Farmacologia (Lisbon, Portugal)
2021/02/18	DOES A SINGLE BINGE DOSING OF 4-CLOROETHCATHINONE (4-CEC) IMPAIR LEARNING AND MEMORY ABILITIES IN YOUNG MICE?	Sociedade Portuguesa de Farmacologia - Annual Meeting 2021 Sociedade Portuguesa de Farmacologia (Lisbon, Portugal)
2021/02/18	NANOBODY-BASED STRATEGIES TO TARGET S100B AND IMPROVE RECOVERY IN AN EX VIVO DEMYELINATING MODEL	Sociedade Portuguesa de Farmacologia - Annual Meeting 2021 Sociedade Portuguesa de Farmacologia (Lisbon, Portugal)
2020/09	Pentamidine as a new therapeutic strategy against Multiple Sclerosis-like pathology	8th Joint ACTRIMS-ECTRIMS Meeting ECTRIMS-ACTRIMS (Washington, Estados Unidos)
2020/01/24	Neuronal miR-124 modulation as a dual-front approach in AD: Benefits for neuronal homeostasis and paracrine microglia immunomodulation.	Meeting Juntos pelo Fernando, Faculty of Medicine University of Lisbon (Lisboa, Portugal)
2019/11	Microglia: responders or inducers of neurodegenerative disorders	CNC Seminars Universidade de Coimbra (Coimbra, Portugal)
2019/10	Human iPSC-derived astrocytes as a model to study neuroinflammation and implications on cell to cell trafficking	1th International Meeting of Portuguese Society for Stem Cells and Cell Therapies Portuguese Society for Stem Cells and Cell Therapies (Lisboa, Portugal)
2019/10	Neuroinflammation and neurodegeneration – a gliocentric perpective	33rd Meeting for the Study Group of Cerebral Aging and Dementia Study Group of Cerebral Aging and Dementia (Curia, Portugal)
2019/09	S100B as a biomarker and therapeutic target in Multiple Sclerosis	ESN Biennial Meeting - 7th Conference on Molecular Mechanisms of Regulation in the Nervous System ESN Biennial Meeting (Milan, Itália)
2019/09	Interplay between glial-immune cells in multiple sclerosis	18th National Meeting of the Spanish Neuroscience Society (SENC), 18th National Meeting of the Spanish Neuroscience Society (SENC), (Santiago de Compostela, Espanha)
2019/05/30	S100B has crucial role in neuroinflammation and immune response in the in vivo model of Multiple Sclerosis.	XIV Meeting of the Portuguese Society for Neuroscience (SPN) Portuguese Society for Neuroscience (SPN) (Lisboa, Portugal)
2019/05/29	Immunomodulation of microglia inflammatory repertoire by dynamic miR-124 signature of APP-Swe neuronal cells.	IV Symposium of the Portuguese Glial Network Portuguese Glial Network (Lisboa, Portugal)
2019/05	Microglia: much more than M1 and M2 phenotypes	IV Symposium of the Portuguese Glial Network Portuguese Glial Network (Lisboa, Portugal)
2019/03/26	Morphological and inflammatory aberrancies in homogeneous and heterogeneous populations of human astrocytes generated from AD-iPSCs and consequences in exosomal cargo	14th International Conference on Alzheimer's and Parkinson's Diseases (AD/PD 2019) (Lisboa, Portugal)
2019/03/26	Overexpression of mir-124 in APP-Swe cells is a protective mechanism to maintain their morphology and reduce exosomal inflammatory-miRNA cargo.	14th International Conference on Alzheimer's and Parkinson's Diseases (AD/PD) (Lisboa, Portugal)
2019/02/14	Targeting S100B prevents in vivo Multiple Sclerosis-like pathology.	5th International Porto Congress of Multiple Sclerosis (Porto, Portugal)
2019/01	Relevance of neuroinflammation in demyelinating disorders: from pathogenesis to therapeutic targeting.	Chemistry Biology Crosstalks Department of Chemistry, Faculdade de Farmácia, Universidade de Lisboa (Lisboa, Portugal)
2018/06	Neuroinflammation in Mutiple Sclerosis: from target discovery to development of a therapeutic strategy	Seminários CNC (coimbra, Portugal)
2018/03	Multiple sclerosis: a journey from target discovery to therapeutic strategy assay.	9th AIMS - Annual International Medical Students Meeting. (Lisbo, Portugal)
2018/02	Exosomes from SH-APPSwe cells recapitulate their microRNA profile and trigger microglial autophagic dysfunction	XLVIII Reunião Anual da Sociedade Portuguesa de Farmacologia Faculty of Medicine of the University of Lisbon (Lisboa, Portugal)
2017/11	Role of astrocyte activation in demyelination. ongress of Portuguese society of Neurology. Lisboa, Portugal, Nov 16-18, 2017.C	Congress of Portuguese society of Neurology. (lis, Portugal)
2017/05	Glia interplay during demyelination.	II Symposium – Portuguese Glial Network. Glial cells: much more than glue. ICVS/3B’s, (Braga , Portugal)
2016/11	Targeting in situ neuroinflammation in MS.	6th Annual Meeting Frontiers in Neurology (FIN6). Trinity College Dublin, (Dublin, Irlanda)
2016/11	Tackling neuroinflammation in multiple sclerosis.	I Symposium – Portuguese Glial Network. ICVS/3B’s, (Braga, Portugal)
2016/06	Neuron-glial interplay during neurodevelopment and neurodegenerative disorders.	Understanding the Molecular Brain in Health and Disease Simposium. Faculdade Ciências Universidade Lisboa, (lisbo, Portugal)
2015/11	Tackling S100B as a new player in Multiple Sclerosis.	I Congress in Health Sciences Research towards Innovation and entrepreneurship. (covilhã, Portugal)
2015/06	Tackling S100B in Multiple Sclerosis.	Neuroscience Seminars. IMM, FMULisboa (Lisboa, Portugal)
2015/03	S100B: a new crucial player in Multiple Sclerosis.	VI Jornadas Nacionais de Ciências Biomédicas, Universidade Algarve, (Faro, Portugal)

Orientação

	Título / Tema Papel desempenhado	Curso (Tipo) Instituição / Organização
2024 - Atual	Avanços na investigação sobre linfomas: do diagnóstico à terapia Orientador	Análises Clínicas (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2024 - Atual	Envolvimento do sistema nervoso central (SNC) em neoplasias malignas hematológicas Orientador	Análises Clínicas (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2024 - Atual	Linfoma Nodal da Zona Marginal – O peso dos critérios morfológicos, fenotípicos e clínicos no diagnóstico da doença, análise retrospetiva Coorientador	Análises Clínicas (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2023 - Atual	Investigating Microglia-T Cell Interactions and Demyelination in a 3D Brainsphere Model of Multiple Sclerosis: Development of new therapeutic Strategies Orientador	Farmácia (Doutoramento) Universidade de Lisboa Faculdade de Farmácia, Portugal
2023 - Atual	Cerebral spinal fluid and plasma biomarkers in late-onset Spinal Muscular Atrophy patients treated with Nusinersen Orientador	Ciências Biofarmacêuticas (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2023 - Atual	Hericium erinaceus polyphenolic and polysaccharides on the strive against Alzheimer’s Disease Orientador	Qualidade Alimentar e Saúde (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2022/01/01 - Atual	Deciphering the role of microglia-T cells interplay upon viral infection: impact in Multiple Sclerosis progression Orientador	Farmácia (Doutoramento) Universidade de Lisboa Faculdade de Farmácia, Portugal
2022/01/01 - Atual	Nanovaccine for oral immunisation to break the link between periodontitis and Alzheimer’s disease Orientador	Farmácia (Doutoramento) Universidade de Lisboa Faculdade de Farmácia, Portugal
2022/01/01 - Atual	BDNF receptor cleavage in Alzheimer's disease: unveiling the impact on microglia Coorientador	Programa Doutoral do Centro Académico de Medicina de Lisboa (ramo de Medicina; ramo de Ciências Biomédicas; ramo de Ciências e Tecnologias da Saúde) (Doutoramento) Universidade de Lisboa Faculdade de Medicina, Portugal
2022 - Atual	Avaliação do risco cardiovascular em doentes com hiperferritinemia Orientador	Análises Clínicas (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2022/10/01 - 2023/11	New in vitro model of microglia-derived from human PBMCs to unravel their contribution in neurodegenerative disorders Orientador	Ciências Biofarmacêuticas (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2022/01/01 - 2023/05/31	Innovative platform for in vivo imaging of myelin clearance during Multiple Sclerosis progression Orientador	Farmácia (Doutoramento) Universidade de Lisboa Faculdade de Farmácia, Portugal
2022 - 2023	Mieloma Múltiplo: do Diagnóstico à Terapêutica Orientador	Análises Clínicas (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2022 - 2023	O papel da microglia no desenvolvimento da Esclerose Múltipla Orientador	Análises Clínicas (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2021 - 2023	Terapêutica com células CAR-T: Novas Aplicações Terapêuticas em Doenças Hematológicas Orientador	Análises Clínicas (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2019 - 2023	Deciphering the role of neuroinflammation in the psycho-pathology and frailty index of multiple sclerosis Orientador de Ana Rita Ribeiro	Farmácia (Doutoramento) Universidade de Lisboa Faculdade de Farmácia, Portugal
2021/10/01 - 2022/12	Detection of Age-associated Changes of the Targets of Disease Modifying Therapies in Multiple Sclerosis Orientador	Ciências Biofarmacêuticas (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2021/10/01 - 2022/12	Neuronal and behavioral alterations after intake of N-ethylpentylone in CD-1 mice Orientador	Ciências Biofarmacêuticas (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2020/09/01 - 2021/11/09	Effects of Newly Detected Synthetic Cathinones on the Central Nervous System Orientador	Ciências Biofarmacêuticas (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2019/09 - 2021/03	The impact of BDNF receptor cleavage in Alzheimer’s disease-associated Neuroinflammation. Orientador de Mafalda Manso	Bioquímica (Mestrado) Universidade de Lisboa Faculdade de Ciências, Portugal
2019/09 - 2021/01/29	Organotypic brain slice cultures as a model to study supressors of amyloid-ß toxicity relevant in Alzheimer’s disease. Coorientador	Bioquímica (Mestrado) Universidade de Lisboa Faculdade de Ciências, Portugal
2019/09 - 2021/01	Role of CNS cells in ischemia-reperfusion lesion associated with stroke. Coorientador de Sofia Santos	Ciências Biofarmacêuticas (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2019/09 - 2020/12/17	Tackling the role of S100B and associated neuroinflammation in an ex vivo demyelinating model. Orientador	Biologia Celular e Molecular (Mestrado) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2018 - 2020/06/05	Role of S100B in EAE pathogenesis Orientador	Neurociências (Mestrado) Universidade de Lisboa Faculdade de Medicina, Portugal
2018 - 2019/10	BASHY dyes for characterization of demyelination and possible microglia targeting Orientador	Genética Molecular e Biomedicina (Mestrado) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2017 - 2019	Benefits of targeting microRNAs to prevent AD-related neurodegeneration and inflammation by cell-derived exosomes Coorientador	Ciências Biofarmacêuticas (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2014 - 2019	The role of S100B in Multiple Sclerosis: from a biomarker to a therapeutic target Orientador de Andreia Barateiro
2013/09/01 - 2018/04/04	DECIPHERING THE INVOLVEMENT OF S100B-RAGE AXIS IN INFLAMMATION-ASSOCIATED MYELIN DAMAGE Orientador de Gisela Santos	Farmácia (Doutoramento) Universidade de Lisboa Faculdade de Farmácia, Portugal
2017 - 2018	Target S100B to reduce Experimental Autoimmune Encephalomyelitis pathogenesis Orientador de Catarina da Silva Barros	Ciências Biofarmacêuticas (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2017 - 2018	Vesicular Trafficking in Alzheimer’s Disease Coorientador de Sofia Gravanita Ferreira	Genética Molecular e Biomedicina (Mestrado) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2016 - 2017	S100B targeting to reduce demyelination and EAE pathogenesis Orientador de Pedro Filipe Marques Pascoal	Ciências Biofarmacêuticas (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2016 - 2017	Dissecting deregulated cell-to-cell communication in in vitro Alzheimer’s Disease models Coorientador	Genética Molecular e Biomedicina (Mestrado) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2011 - 2017	Evaluation of neuroprotective and neurotoxic functions of different microglia phenotypes in Alzheimer’s disease onset and progression, using in-vitro and in-vivo models Coorientador de Claudia Caldeira	Farmácia (Doutoramento) Universidade de Lisboa Faculdade de Farmácia, Portugal
2014 - 2016	Role of microRNA in microglial phenotype during the progression of Alzheimer’s disease Orientador de Mafalda Aurélio Monteiro	Ciências Biofarmacêuticas (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2014 - 2015	Modulation of microglia reactivity by S100B in Multiple Sclerosis Orientador de Carla Isabel Silveira Ferreira	Ciências Biofarmacêuticas (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2012 - 2014	Role of S100B on central nervous system demyelination and remyelination Orientador de Vera Alexandra Padrela Martins Afonso	Ciências Biofarmacêuticas (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2008 - 2012	Bilirubin dysregulates myelination in early neonatal life Coorientador de Andreia Barateiro	Farmácia (Doutoramento) Universidade de Lisboa Faculdade de Farmácia, Portugal

Organização de evento

	Nome do evento Tipo de evento (Tipo de participação)	Instituição / Organização
2019 - Atual	XIV European Meeting on Glial Cells in Health and Disease - Local organizing committee (2019) Congresso (Membro da Comissão Organizadora)
2019 - Atual	IV Symposium of the Portuguese Glial Network - organizing committee (2019) Simpósio (Membro da Comissão Organizadora)	Universidade de Lisboa Faculdade de Farmácia, Portugal
2019 - Atual	Cientificamente Provável, the participation of iMed.ULisboa in this initiative has been contributing to the promotion of scientific literacy and enrichment of the training path of young people, motivating them to deepen their knowledge and pursue higher studies in their areas of interest. (2019/05/03) Oficina (workshop) (Membro da Comissão Organizadora)	Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal Universidade de Lisboa Faculdade de Farmácia, Portugal
2010 - Atual	Brain Awareness Week - Dissemination of Neuroscience Science to elementary and high school students under the Brain Awareness Week initiative created by the Dana Foundation, USA, which aims to raise awareness of the general public, including students, for the progress and benefit of brain study. (2021/03/15 - 2021/03/19) Seminário (Coorganizador)	Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal Universidade de Lisboa Faculdade de Farmácia, Portugal
2024/06/25 - 2024/06/29	Symposium of the FENS Forum 2024- "Diverse glial contribution to demyelination and Multiple Sclerosis" (2024/06/25 - 2024/06/29) Simpósio (Presidente da Comissão Organizadora)	Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal Universidade de Lisboa Faculdade de Farmácia, Portugal
2023/07 - 2023/07	SCIENTIFIC OCCUPATION OF YOUNG PEOPLE ON VACATION 2023, by Ciência Viva (2023/07 - 2023/07) Oficina (workshop) (Presidente da Comissão Organizadora)	Universidade de Lisboa Faculdade de Farmácia, Portugal Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
2022/07 - 2022/07	SCIENTIFIC OCCUPATION OF YOUNG PEOPLE ON VACATION 2022, by Ciência Viva (2022/07 - 2022/07) Oficina (workshop) (Presidente da Comissão Organizadora)	Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal Universidade de Lisboa Faculdade de Farmácia, Portugal
2021/07 - 2021/07	SCIENTIFIC OCCUPATION OF YOUNG PEOPLE ON VACATION 2021, by Ciência Viva (2021/07 - 2021/07) Oficina (workshop) (Presidente da Comissão Organizadora)	Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal Universidade de Lisboa Faculdade de Farmácia, Portugal
2014/11 - 2014/11	Profiling alterations in microglia dynamic properties by neuroinflammation (2014/11) Oficina (workshop)	Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
2012/10 - 2012/10	Myelin: genesis, disease and repair (2012/10 - 2012/10) Simpósio (Presidente da Comissão Organizadora)	Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
2012/02 - 2012/02	xCELLigence System On Your Campus (2012/02 - 2012/02) Oficina (workshop) (Presidente da Comissão Organizadora)	Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal

Júri de grau académico

	Tema Tipo de participação	Nome do candidato (Tipo de grau) Instituição / Organização
2023/12	Investigations of S100 proteins and their role in huntingtin aggregation Arguente principal	Marta Sofia Silva da Cruz Botelho (Mestrado) Universidade de Lisboa Faculdade de Ciências, Portugal
2023/12	Comparative Efficacy of CK1 Inhibitors and miRNA loaded Exosomes on the Recovery of ALS Injured Microglia Arguente principal	Rita Jorge Barbosa (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2023/12	Mieloma Múltiplo: do Diagnóstico à Terapêutica Orientador	Rita Margarida Madeira Gonçalves (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2023/11	Terapêutica com células CAR-T: Novas Aplicações Terapêuticas em Doenças Hematológicas Orientador	Carolina Miki Sakamoto Tasca (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2023/11	New in vitro model of microglia derived from human PBMCs to unravel their contribution in neurodegenerative disorders Orientador	Inês Sofia Tomaz da Costa (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2023/11	O papel da microglia no desenvolvimento da Esclerose Múltipla Orientador	Rita Alexandra Andrade da Cruz Soares Ramos (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2023/11	Aplicação de nanopartículas metálicas no tratamento do cancro da próstata Presidente do júri	Sara Inês Bastos Pinho (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2023/11	Contaminantes nos Alimentos - Microplásticos Presidente do júri	Mafalda Inês Domingos Potier (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2023/11	Formulation, characterization and stability studies of emulsions containing different vegetable oils and caffeine as active compound Presidente do júri	Ana Margarida Colaço Dionísio (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2023/07	Investigation of novel compounds to prevent TrkB-FL cleavage Arguente principal	Lia Marta Barreira Fernandes (Mestrado) Universidade de Lisboa Faculdade de Medicina, Portugal
2023/06	Microglia depletion impact in epileptogenesis Focusing on NLRP3 inflammasome pathways Arguente principal	Carolina Maria Vieira Capela (Mestrado) Universidade de Lisboa Instituto Superior Técnico, Portugal
2023/02/10	Developing molecular tools for the study of the STAT3 pathway Arguente	Ricardo Letra-Vilela (Doutoramento) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2022/12/20	ROLE OF SP1 AND PADI2 ON OLIGODENDROCYTE DIFFERENTIATION ENHANCED BY MECHANOTRANSDUCTION Arguente principal	Tânia Milene Pires Lourenço (Doutoramento) Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2022/12/19	Detection of age-associated changes of the targets of disease modifying therapies in Multiple Sclerosis Orientador	Raquel Rei Pereira (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2022/12/13	Neuronal and behavioral alterations after intake of N-ethylpentylone in CD-1 Orientador	Catarina Isabel Venda Grilo (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2022/07/20	Deadly Delivery: Unraveling the Contribution of Microglial Exosomes to Retinal Degeneration in Glaucoma Arguente	Inês Sofia Dinis Aires (Doutoramento) Universidade de Coimbra Faculdade de Medicina, Portugal
2022/07/04	Search for novel compounds to prevent TrkB-FL cleavage Arguente principal	Sara Inteiro de Oliveira (Mestrado) Universidade de Lisboa Faculdade de Medicina, Portugal
2022/06/03	Mechanical principles driving microglia activation Arguente principal	Pedro Neves Melo (Doutoramento) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2022/04/29	DIFFERENTIAL ROLE OF PGC-1a ISOFORMS IN THE MODULATION OF ASTROCYTES REACTIVE PHENOTYPE Arguente principal	CARLOTA DE SÁ LEMOS GARCIA (Mestrado) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2021/12/10	Exploring cognition, 4-octyl itaconate treatment and clinical scoring in the animal model of Multiple Sclerosis, Experimental Autoimmune Encephalomyelitis Arguente principal	Maria Inês Portela de Melo (Mestrado) Universidade do Porto Faculdade de Medicina, Portugal
2021/12/10	Can the extracellular vesicles released by Müller glial cells provide neuroprotection to retinal ganglion cells? Arguente principal	Carolina Marques dos Santos (Mestrado) Universidade de Coimbra Faculdade de Medicina, Portugal
2021/12/09	Development of new pharmacological approaches in ischemic stroke: A Systematic Review of transient MCAO model in rats. Arguente	João Solas (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2021/11/09	Effects Of Newly Detected Synthetic Cathinones On The Central Nervous System Orientador	Ana Margarida Barata Leitão (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2021/07/19	Bacteriological etiology of Alzheimer’s Disease: Possibility of a vaccine? Arguente principal	Alexandra Filipa Neves Gomes (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2021/07/01	Characterization of BDNF signalling in the neonatal phencyclidine mouse model of schizophrenia Arguente principal	Céline Felicidade Freitas (Mestrado) Universidade de Lisboa Faculdade de Medicina, Portugal
2021/06/25	Characterization of the Cancer Antigen Release Profile of Nanoparticle-based Immunotherapy Arguente	Maria Machado Rodrigues González (Outro) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2021/06/25	Development of nanoparticle-based immunotherapy using chitosan as an immunomodulator Arguente	Pedro Lino Rosado (Outro) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2021/06/22	Unveiling the link between BDNF alterations and cognitive deficits in Schizophrenia Arguente	Sara Luísa Ramalho Tanqueiro (Doutoramento) Universidade de Lisboa Faculdade de Medicina, Portugal
2021/06/20	Determining the Cellular and Molecular Mechanisms Behind Glial Cell Phagocytosis Arguente	Lynn Nazareth (Doutoramento) School of Pharmacy and Medical Science, Griffith Health, Griffith University, Austrália
2021/03/22	Unravelling the contribution of glial cells for the neuroinflammatory milieu of epileptic-like organotypic slices Arguente	Mafalda Cagica Pinto de Carvalho (Mestrado) Universidade de Lisboa Faculdade de Ciências, Portugal
2021/03/18	The impact of BDNF receptor cleavage in Alzheimer’s disease-associated Neuroinflammationn Orientador	Mafalda Manso (Mestrado) Universidade de Lisboa Faculdade de Ciências, Portugal
2021/03/18	The impact of BDNF receptor cleavage in Alzheimer’s disease-associated Neuroinflammation Orientador	Mafalda Ferreira Manso (Mestrado) Universidade de Lisboa Faculdade de Ciências, Portugal
2021/01/30	Organotypic brain slice cultures as a model to study supressors of Amyloid-ß toxicity relevant in Alzheimer’s Disease Orientador	Francisco Schäller Dias (Mestrado) Universidade de Lisboa Faculdade de Ciências, Portugal
2021/01/14	Neuronal miR-124 in Alzheimer's Disease human models: from cell functioning to trafficking Arguente	Henrique Paulino Sasso Pereira Mamede (Mestrado) Universidade de Lisboa Instituto Superior Técnico, Portugal
2020/12/17	Gene deletion and nanobodies strategies to target S100B and improve recovery in an ex vivo demyelinating model Orientador	Alexandre Nunes Neto (Mestrado) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2020/12	Wound Healing: The role of Exosomes Arguente principal	Júlia Carolina Lopes Matos (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2020/12	Linfoma de Hodgkin. Diagnóstico e terapêuticas atuais Arguente principal	Nuno Manuel Cepeda da Silva (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2020/11	Leucemia Linfocítica Crónica Diagnóstico e terapêutica: Novas abordagens Arguente principal	Maria João Correia Goulart (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2020/11	Mieloma Múltiplo: Diagnóstico e Terapêutica. Novos Marcadores da Doença Arguente principal	Ana Margarida Murteira Damásio Boieiro Cotovio (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2020/06/05	Role of S100B in EAE pathogenesis Orientador	Beatriz dos Santos Pinto Soromenho (Mestrado) Universidade de Lisboa Faculdade de Medicina, Portugal
2020/02/17	Evaluating cortical transcriptomic differences between Alzheimer’s disease PSEN1-mutated mouse models and human patients, and their implications in drug development Arguente	Sara Rodrigues Mendes (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2020/01/21	TUNING CELL DEATH AND INFLAMMATION IN PARKINSON’S DISEASE Arguente	Pedro Dionísio (Doutoramento) Universidade de Lisboa Faculdade de Farmácia, Portugal
2020/01/13	Characterization of blood markers and their implication in human aging Arguente principal	Ainhoa Alberro Garitano (Doutoramento) Universidad del País Vasco, Espanha
2019/12/12	Impact of the Modulation of Tumor Vasculature on Cancer Vaccine Efficacy against Colorectal Cancer Arguente	Sandra Pena (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2019/11/19	Implication of induced Reelin-KO in the deposition of Aß plaques in Alzheimer´s Disease mouse models Arguente principal	Rita Patrocínio (Mestrado) Universidade de Lisboa Instituto Superior Técnico, Portugal
2019/11/06	Vectored immunoprophylaxis to produce anti-BACE1 nanobodies for treatment of Alzheimer’s disease Arguente principal	Eugénia Machado (Mestrado) Universidade de Lisboa Faculdade de Ciências, Portugal
2019/09/10	MICROGLIA-MEDIATED REMODELLING OF THE CEREBELLAR CIRCUIT Arguente principal	Pedro Ferreira (Mestrado) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2019/07/25	Dissecting pentraxin-3 role in the modulation of Multiple Sclerosis Arguente principal	Joana Lima Sá (Mestrado) Universidade do Minho Escola de Medicina, Portugal
2019/07/25	The potential role of innate immune memory in Multiple Sclerosis disease using autoimmune experimental encephalomyellitis mouse model Arguente principal	Marta Monteiro (Mestrado) Universidade do Minho Escola de Medicina, Portugal
2019/06/18	The calcium binding S100B protein as a new modulator of amyloid-ß peptide aggregation Arguente	Joana Cristóvão (Doutoramento) Universidade de Lisboa Faculdade de Ciências, Portugal
2019	UNVEILLING THE INTERPLAY BETWEEN ACTIVATED ASTROCYTES AND NEURONS IN AN IN VITRO MODEL OF ALZHEIMER’S DISEASE Orientador	Ana Filipa da Costa Moreira (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2018	Deciphering the involvement of S100B-RAGE axis in inflammation-associated myelin damage Orientador	Gisela Filipa Assunção Santos (Doutoramento) Universidade de Lisboa Faculdade de Farmácia, Portugal
2018	Mechanisms of actin cytoskeletal dynamics in oligodendrocyte biology and myelin formation Arguente principal	Maria Manuela Azevedo (Doutoramento) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2018	Targeting mitochondria-nucleus communication to improve aging-impaired neurogenesis Arguente principal	Marcia Filipa Freire Dias da Costa (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2018	Changes in Erythropoiesis and Transferrin Receptor 2 in Malaria-induced Anemia Arguente principal	Ana Catarina Guilherme Pêgo (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2018	TARGETING MIR-124 IN MOTOR NEURONS AS A THERAPEUTIC STRATEGY TO PREVENT NEURODEGENERATION AND GLIAL ACTIVATION IN ALS Arguente principal	Daniela Catarina Ribeiro Vizinha (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2018	Role of adenosine A2A Receptors in Multiple Sclerosis: Neural Stem Cells as a potential target Arguente principal	Ana Marta Alonso Gomes (Mestrado) Universidade de Lisboa Instituto Superior Técnico, Portugal
2018	Astrocyte-specific Transcriptomic Response to PGC-1alpha Isoforms Arguente principal	Mariana Messias de Jesus Rufino Ribeiro (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2017	S100B targeting to reduce demyelination and EAE pathogenesis Orientador	Pedro Filipe Marques Pascoal (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2017	Visualization of STAT3 dimers in living cells Arguente principal	Ana Catarina da Silva Almeida (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2016	Role of microRNA in microglial phenotype during the progression of Alzheimer’s disease Orientador	Mafalda Aurélio Monteiro (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2015	Impact of Mechanotransduction in the Context of Central Nervous System Diseases Arguente principal	Daniela Nogueira da Rocha Mar (Doutoramento) Universidade do Porto Faculdade de Engenharia, Portugal
2015	Modulation of microglia reactivity by S100B in Multiple Sclerosis Orientador	Carla Isabel Silveira Ferreira (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2015	Exploring the modulatory role of A2A receptors in oligodendrogenesis derived from neural stem/progenitor cells of the subventricular zone Arguente principal	Ana Iolanda d’Armada Moreira (Mestrado) Universidade de Lisboa Faculdade de Medicina, Portugal
2014	Role of S100B on central nervous system demyelination and remyelination Orientador	Vera Alexandra Padrela Martins Afonso (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2014	Organotypic Hippocampal Slice Culture Model of Epileptogenesis: Electrophysiological and Molecular Features Arguente principal	Noémia Marisa Felix Pereira (Mestrado) Universidade de Lisboa Faculdade de Medicina, Portugal
2012	Bilirubin dysregulates myelination in early neonatal life Orientador	Andreia Pereira Barateiro (Doutoramento) Universidade de Lisboa Faculdade de Farmácia, Portugal

Arbitragem científica em conferência

	Nome da conferência	Local da conferência
2019 - Atual	XVI Meeting of the Portuguese Society for Neuroscience
2019 - Atual	XIV European Meeting on Glial Cells in Health and Disease

Comissão de avaliação

	Descrição da atividade Tipo de assessoria	Instituição / Organização
2024 - Atual	ERA4HEALTH_NUTRIBRAIN Avaliador
2023 - Atual	MSCA POSTDOCTORAL FELLOWSHIPS 2023 Avaliador	European Commission, Bélgica
2016 - Atual	Alzheimer's Association – Call for Alzheimer's Association Research Grant (AARG) Avaliador
2015 - Atual	Italian Ministry of Health, Scientific Research and Health Innovation - Call for Research
2014 - Atual	MS Research Australia -Research projects Avaliador
2019 - 2019	Austrian Research Projects 2019 Avaliador	Fonds zur Förderung der wissenschaftlichen Forschung, Áustria
2016 - 2016	Israel Science Foundation Avaliador	Israel Science Foundation, Israel
2015 - 2015	Medical Research Council, UK Avaliador	Medical Research Council, Reino Unido

Curso / Disciplina lecionado

	Disciplina	Curso (Tipo)	Instituição / Organização
2022 - Atual	Master Laboratory Medicine	Análises Clínicas (Mestrado integrado)	Universidade de Lisboa Faculdade de Farmácia, Portugal
2020/07/06 - Atual	Advances in Neuropharmaceutics	Farmácia	Universidade de Lisboa Faculdade de Farmácia, Portugal
2017 - Atual	Master in Biochemistry	(Mestrado)	Universidade de Lisboa Faculdade de Ciências, Portugal
2015 - Atual	Master/PhD in Neurosciences	(Mestrado)	Universidade de Lisboa Faculdade de Medicina, Portugal
2012 - Atual	Master in Biopharmaceutical Sciences: Development and Organization of the Nervous System, Neuropathology and Neuropharmacology, Brain Barriers and Drug development, Physiopathology of Neuroinflammation (Regency).	(Mestrado)	Universidade de Lisboa Faculdade de Farmácia, Portugal
2010 - Atual	Master in Pharmaceutical Chemistry and Therapeutics: Pharmaceutical Chemistry II	(Mestrado)
2009 - Atual	Integrated master degree in Pharmaceutical Sciences: Anatomy, Biology Laboratory, Histology, Hematology.	master (Mestrado integrado)	Universidade de Lisboa Faculdade de Farmácia, Portugal
2015 - 2020	Molecular Biomarkers and Technologies	Farmácia (Doutoramento)	Universidade de Lisboa Faculdade de Farmácia, Portugal
2016 - 2016	PhD Programme GABBA	(Curso de doutoramento (conclusão de unidades curriculares))	Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2014 - 2015	PhD Programme Human Genetics and Infectious Diseases	(Curso de doutoramento (conclusão de unidades curriculares))	Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

Membro de associação

	Nome da associação	Tipo de participação
2016 - Atual	Portuguese Glia Network	Outreach team
2008 - Atual	Portuguese Society of Neurosciences
2008 - Atual	Federation of European Neuroscience Societies
2002/04/01 - Atual	Ordem dos Farmacêuticos

Tutoria

	Tópico	Nome do aluno
2024/02 - Atual	Treatment of innovative human 3D brainspheres with pentamidine to tackle the role of S100B in human demyelination	annelore Douven
2023/01 - 2023/09	Role of glial cells in the pathogenesis of Autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS)	Elisa Farsetti
2022/10 - 2022/12	Characterization of iMG to a demyelinating insult	Paula Hebing

Distinções

Prémio

2023	Portuguese call for research projects 2023 - BIOCODEX MICROBIOTA FOUNDATION
2022	ARSACS Project -2022-2023 Ataxia Canada, Canadá
2017	Best Oral Communication at 4th International Porto Congress of Multiple Sclerosis Merck KGaA, Alemanha
2017	Grant for Multiple Sclerosis Innovation (GMSI) Merck & Co Inc, Estados Unidos
2013	Bolsa Inovação da Secção Regional de Lisboa da Ordem dos Farmacêuticos Ordem dos Farmaceuticos, Portugal
2012	Edgar Cruz e Silva Prize Grupo de Estudo de Envelhecimento Cerebral e Demências (GEECD), Portugal
2011	Medal of Honor for Women in Science L’Oréal Fundação para a Ciência e a Tecnologia, Portugal UNESCO Office of International Standards and Legal Affairs, França Fondation L'Oréal, França
2007	EMBO short term felowship
2002	Programa Gulbenkian de Estímulo à Investigação Fundação Calouste Gulbenkian, Portugal