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First degree in Biochemistry (1992) and MSc in Biomedical Engineering (1996) from the University of Coimbra, Portugal. PhD work under Prof. Terry Jones’ supervision at the MRC - Cyclotron Unit, Hammersmith Hospital in London, UK (2002). From 2000 to 2009, helped to design and supervised the construction of the Institute for Nuclear Sciences Applied to Health (ICNAS) a leading facility in Portugal for Nuclear Imaging based at the University of Coimbra. He is the current Director of the Institute and the head of the Radiochemistry Laboratory (RCL). ICNAS has extensive expertise in the development of radiopharmaceuticals for Oncology, Cardiology and Neuroscience and is fully equipped for clinical imaging (2 PET/CT and a 3T MR) as well as pre-clinical studies (including an in-house developed world leading high-resolution small animal PET with 0.3 mm resolution, a 9.4T micro-MRI, an optical imaging system and a photoacoustic tomography device). The RCL hosts 2 cyclotrons (IBA cyclone 18/9 and the first IBA Kiube variable energy, installed in 2019) and is fully licensed as a GMP manufacturing site, currently producing more than 20 different tracers based on 11C, 13N, 18F, 68Ga, 61Cu and 64Cu. The facility is the main supplier of PET radiopharmaceuticals for Portugal, through its subsidiary (ICNAS-P, a company fully owned by the University) that currently has 6 radiopharmaceuticals in the market (FDG, FCH, NaF, 68Ga-DOTANOC, 68Ga-PSMA-11 and F-DOPA). Antero is manager and Head of Production for ICNAS-P from the start. Antero’s research interests include development of targeted probes for molecular imaging, PET, SPECT, radiopharmaceutical development, PET Radiopharmacy and Quality Control, pre-clinical imaging and clinical trials. The Institute is currently participating in more than 30 clinical trials and has recently received approval, by the authorities, of its first investigator driven clinical trial. Regarding technology transfer, Antero promoted the start of 3 spin-off companies from the University of Coimbra, one of them (Fluidomica, Lda) specializes in supplying target solutions for radiometal production. He is a member of the European Pharmacopoeia Group 14 and an Expert in several Technical Committees and Field Missions for IAEA (International Atomic Energy Agency). He currently holds patents in Europe, US and Japan regarding the production of gallium-68 using liquid targets.
Identificação

Identificação pessoal

Nome completo
Antero José Pena Afonso de Abrunhosa

Nomes de citação

  • Abrunhosa, Antero
  • Abrunhosa, Antero J

Identificadores de autor

Ciência ID
2E1B-49C3-207D
ORCID iD
0000-0002-4145-854X

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Formação
Grau Classificação
2002
Concluído
Biomedical Sciences (Doutoramento)
Universidade de Coimbra Faculdade de Medicina, Portugal
Distinction and praise
1996
Concluído
Biomedical Engineering (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
Very Good
1992
Concluído
Biochemistry (Licenciatura)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
Good
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento
Empregador
2009/09/01 - Atual Investigador (Investigação) Universidade de Coimbra Instituto de Ciências Nucleares Aplicadas à Saúde, Portugal
2015 - 2019 Investigador (Investigação) CNC.IBILI, Portugal

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento
Empregador
2017 - 2018 Leitor (Docente Universitário) Universidade de Coimbra, Portugal
2013 - 2015 Professor Coordenador (Docente Ensino Superior Politécnico) Escola Superior de Saúde Ribeiro Sanches, Portugal
2013 - 2015 Professor Coordenador (Docente Ensino Superior Politécnico) Escola Superior de Saúde Ribeiro Sanches, Portugal

Cargos e Funções

Categoria Profissional
Instituição de acolhimento
Empregador
2017/11/22 - Atual Director de Unidade Orgânica Universidade de Coimbra Instituto de Ciências Nucleares Aplicadas à Saúde, Portugal
2017 - 2018 Conselho científico/técnico-científico ou orgão correspondente Universidade de Coimbra, Portugal
2017 - 2018 Coordenação ou direção de centro de investigação, departamento ou equivalente Universidade de Coimbra, Portugal
2017 - 2018 Diretor ou presidente da unidade orgânica Universidade de Coimbra, Portugal
2017 - 2018 Conselho científico/técnico-científico ou orgão correspondente Universidade de Coimbra, Portugal
2017 - 2018 Coordenação ou direção de centro de investigação, departamento ou equivalente Universidade de Coimbra, Portugal
2017 - 2018 Diretor ou presidente da unidade orgânica Universidade de Coimbra, Portugal
2013 - 2015 Conselho científico/técnico-científico ou orgão correspondente Escola Superior de Saúde Ribeiro Sanches, Portugal
2013 - 2015 Conselho científico/técnico-científico ou orgão correspondente Escola Superior de Saúde Ribeiro Sanches, Portugal

Outros

Categoria Profissional
Instituição de acolhimento
Empregador
1999/10/01 - Atual Invited Professor Instituto Politécnico de Coimbra Escola Superior de Tecnologia da Saúde de Coimbra, Portugal
1995/10/01 - 1999/09/30 PhD student MRC Clinical Sciences Centre, Reino Unido
1992/10/01 - 1995/09/30 MSc student Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
1991/10/01 - 1992/09/30 First degree, Final year placement Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
Projetos

Bolsa

Designação Financiadores
2013 - Atual From molecules to man: novel diagnostic imaging tools in neurological and psychiatric disorders
PEst-C/SAU/UI3282/2013 CENTRO-07-ST24-FEDER-00205
QREN
2012 - Atual Molecular and Nano Tools for Cancer Theranostics
EXCL/QEQ-MED/0233/2012
Fundação para a Ciência e a Tecnologia
2008 - Atual A novel technology for single-bed whole-body human molecular imaging with higher sensitivity and resolution
PTDC/SAU-BEB/104630/2008
Fundação para a Ciência e a Tecnologia, I.P.
2008 - Atual Radiolabeled Benzazole Derivatives for In Vivo Imaging of Amyloid Aggregation
PTDC/QUI-QUI/102049/2008
Fundação para a Ciência e a Tecnologia
2006 - Atual Targeted Nanoconstructs for Multimodal Medical Molecular Imaging
PTDC/QUI/70063/2006
Fundação para a Ciência e a Tecnologia
2021 - 2023/12 Radiolabeled EXosomes - a nanotheranostic tool for lung micrometastasis in osteosarcoma
PTDC/BTM-SAL/4451/2020
Fundação para a Ciência e a Tecnologia
2016 - 2018/06 Quantification in PET: construction of a distributed non-invasive system for measuring the arterial input function
PTDC/BBB-BMD/5378/2014
Universidade de Coimbra

Projeto

Designação Financiadores
2021 - 2023/08 LABEL - Radio-marcação de vesiculas extracelulares para aplicações em diagnóstico e terapêuticas
POCI-01-0247-FEDER-049268
PT2020 (FEDER)
2019 - 2021/09 HiRezBrainPET: High Resolution Positron Emission Tomography for Brain Imaging
POCI-01-0247-FEDER-039808
PT2020 (FEDER)
2018 - 2021/07/25 Melhoria cognitiva no cérebro idoso e demência vascular em humanos através da funcionalização do acoplamento neurovascular: uma estratégia mecanística molecular promovida por nitrito e ácido ascórbico da dieta
PTDC/MED-NEU/29099/2017
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Centro Hospitalar e Universitário de Coimbra EPE, Portugal

Universidade de Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
2020 - 2020/12 VentiLab 4 COVID-19 .: Laboratório especializado no teste e certificação de equipamentos médicos respiratórios no âmbito da COVID-19
POCI-01-02B7-FEDER-069499
PT2020 (FEDER)
2017 - 2020/01 Synaptic networks and Personalized Medicine Approaches to Understand Neurobehavioural Diseases Across the Lifespan
SAICTPAC/0010/2015
Universidade de Coimbra
2017 - 2019/07 DOPAPET-DCP: Development of an innovative microwave assisted synthesis process for F-DOPA
POCI-01-0247-FEDER-023747
PT2020 (FEDER)
2013 - 2015/09/30 O metilfenidato e as alterações na barreira hemato-encefálica numa situação fisiológica e na perturbação de hiperatividade com défice de atenção
PTDC/NEU-OSD/0312/2012
Universidade de Coimbra, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
2005 - 2008/06/30 Tomógrafo PET humano de alta sensibilidade e baixo custo: testes de viabilidade
POCI/SAU-OBS/61642/2004
Laboratório de Instrumentação e Física Experimental de Partículas Coimbra, Portugal

Laboratório de Instrumentação e Física Experimental de Partículas Coimbra, Portugal

Universidade de Coimbra Faculdade de Medicina, Portugal
Fundação para a Ciência e a Tecnologia
1995 - 1999/09/30 UTILIZAÇÃO DO COMPUTADOR NO PROJECTO DE MOLÉCULAS COM INTERESSE PARA UTILIZAÇÃO NO PET E NA SUA SÍNTESE AUTOMÁTICA
PRAXIS XXI/BD/4563/94
Universidade de Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
Produções

Publicações

Artigo em conferência
  1. Pereira, C.; Abrunhosa, A.; Cruz, A.; Ferreira, N.; Moreira, A.; Oliveira, F.; Patricio, M.; Caramelo, F.. "Distributed non-invasive system for measuring the arterial input function in PET". 2018.
    10.1109/NSSMIC.2017.8532753
  2. Alves, F.; Alves, V.H.; Neves, A.C.B.; Do Carmo, S.J.C.; Nactergal, B.; Hellas, V.; Kral, E.; Gonçalves-Gameiro, C.; Abrunhosa, A.J.. "Cyclotron production of Ga-68 for human use from liquid targets: From theory to practice". 2017.
    10.1063/1.4983532
  3. Cristina Serra; Angela Neves; Antero J. Abrunhosa; Luis F. Metello. "Optimization and validation of [13N]-NH3 production for clinical studies of positron emission tomography in the evaluation of myocardial perfusion". 2015.
    10.1109/enbeng.2015.7088887
  4. Serra, C.; Neves, A.; Abrunhosa, A.J.; Metello, L.F.. "Optimization and validation of [13N]-NH3 production for clinical studies of positron emission tomography in the evaluation of myocardial perfusion". 2015.
    10.1109/ENBENG.2015.7088887
  5. Serra, Cristina; Neves, Angela; Abrunhosa, Antero J.; Metello, Luis F.. "Optimization and validation of [13N]-NH3 production for clinical studies of positron emission tomography in the evaluation of myocardial perfusion". 2015.
    10.1109/ENBENG.2015.7088887
  6. Vitor H. Alves; Antero J. Abrunhosa; Miguel Castelo-Branco. "Optimisation of synthesis, purification and reformulation of (R)-[N-Methyl-11C]PK11195 for in vivo PET imaging studies". 2013.
    10.1109/enbeng.2013.6518428
  7. Alves, V.H.; Abrunhosa, A.J.; Castelo-Branco, M.. "Optimisation of synthesis, purification and reformulation of (R)-[N-Methyl-11C]PK11195 for in vivo PET imaging studies". 2013.
    10.1109/ENBENG.2013.6518428
  8. Faustino, R.; Rio, J.; Ferreira, C.; Marques, J.P.; Abrunhosa, A.J.; Ferreira, N.C.; Castelo-Branco, M.; et al. "Image analysis in radiology and nuclear medicine". 2013.
    10.1109/ENBENG.2013.6518385
  9. R. Faustino; A. J. Abrunhosa; M. Castelo-Branco. "Neuronal and developmental effects of high magnetic fields in the development of an intact living organism: Ceanorhabditis elegans". 2012.
    10.1109/enbeng.2012.6331363
  10. Faustino, R.; Abrunhosa, A.J.; Castelo-Branco, M.. "Neuronal and developmental effects of high magnetic fields in the development of an intact living organism: Ceanorhabditis elegans". 2012.
    10.1109/ENBENG.2012.6331363
  11. Clemente, G.; Alves, V.; Abrunhosa, A.J.. "Synthesis optimization of pittsburgh compound B by the captive solvent method". 2012.
    10.1109/ENBENG.2012.6331358
  12. Neves, S.C.; Oliveira, V.E.; Do Carmo, A.; Abrunhosa, A.J.; Botelho, M.F.; Gomes, C.M.. "Elucidation of the drug resistance mechanisms of osteosarcoma cancer stem cells with PET tracers". 2011.
    10.1109/ENBENG.2011.6026060
  13. Gomes, C.M.; Welling, M.M.; Que, I.; Henriquez, N.; Van Der Pluijm, G.; Abrunhosa, A.J.; Botelho, M.F.; et al. "Imaging multidrug resistance in osteosarcoma: A pre-clinical approach using an orthotopic animal model". 2009.
    10.1007/978-3-642-03879-2-219
Artigo em revista
  1. Diliana Rebelo; Francisco Oliveira; Antero Abrunhosa; Cristina Januário; João Lemos; Miguel Castelo-Branco. "A link between synaptic plasticity and reorganization of brain activity in Parkinson's disease". Proceedings of the National Academy of Sciences (2021): https://doi.org/10.1073/pnas.2013962118.
    10.1073/pnas.2013962118
  2. Jorge L; Martins R; Canário N; Xavier C; Abrunhosa A; Santana I; Castelo-Branco M. "Investigating the Spatial Associations Between Amyloid-ß Deposition, Grey Matter Volume, and Neuroinflammation in Alzheimer's Disease.". Journal of Alzheimer's disease : JAD (2021): http://europepmc.org/abstract/med/33523050.
    10.3233/jad-200840
  3. Rebelo, Diliana; Oliveira, Francisco; Abrunhosa, Antero; Januário, Cristina; Lemos, João; Castelo-Branco, Miguel. "A link between synaptic plasticity and reorganization of brain activity in Parkinson's disease". (2021): http://hdl.handle.net/10316/92619.
  4. Sara Almeida; Liliana Santos; Amílcar Falcão; Célia Gomes; Antero Abrunhosa. "In Vivo Tracking of Extracellular Vesicles by Nuclear Imaging: Advances in Radiolabeling Strategies". International Journal of Molecular Sciences (2020): https://doi.org/10.3390/ijms21249443.
    10.3390/ijms21249443
  5. Pinto CIG; Bucar S; Alves V; Fonseca A; Abrunhosa AJ; da Silva CL; Guerreiro JF; Mendes F. "Copper-64 Chloride Exhibits Therapeutic Potential in Three-Dimensional Cellular Models of Prostate Cancer.". Frontiers in molecular biosciences (2020): http://europepmc.org/abstract/med/33335914.
    10.3389/fmolb.2020.609172
  6. Fonseca AI; Alves VH; do Carmo SJC; Falcão A; Abrunhosa AJ; Alves F. "GMP automated purification of copper-61 produced in cyclotron liquid targets: methodological aspects.". Current radiopharmaceuticals (2020): http://europepmc.org/abstract/med/33183218.
    10.2174/1874471013666201112141844
  7. Beatriz Lapa; Ana Cristina Gonçalves; Joana Jorge; Raquel Alves; Ana Salomé Pires; Ana Margarida Abrantes; Margarida Coucelo; et al. "Acute myeloid leukemia sensitivity to metabolic inhibitors: glycolysis showed to be a better therapeutic target". Medical Oncology 37 8 (2020): https://doi.org/10.1007/s12032-020-01394-6.
    10.1007/s12032-020-01394-6
  8. Domingues C; João Ferreira M; Silva R; Oliveira-Santos M; Andreia Gomes; Chichorro N; de Lima JP; et al. "Aortic valve microcalcification and cardiovascular risk: an exploratory study using sodium fluoride in high cardiovascular risk patients.". The international journal of cardiovascular imaging (2020): http://europepmc.org/abstract/med/32342245.
    10.1007/s10554-020-01854-0
  9. Oliveira-Santos, M.; McMahon, G.; Castelo-Branco, M.; Silva, R.; Gomes, A.; Chichorro, N.; Abrunhosa, A.; et al. "Renal artery wall 18F-NaF activity and glomerular filtration rate: an exploratory analysis in a high cardiovascular risk population". Nuclear medicine communications 41 2 (2020): 126-132. http://www.scopus.com/inward/record.url?eid=2-s2.0-85077936746&partnerID=MN8TOARS.
    10.1097/MNM.0000000000001128
  10. Bousquet J; Illario M; Farrell J; Batey N; Carriazo AM; Malva J; Hajjam J; et al. "The Reference Site Collaborative Network of the European Innovation Partnership on Active and Healthy Ageing.". Translational medicine @ UniSa (2019): http://europepmc.org/abstract/med/31360670.
  11. Arnab Banerjee; Vitor Alves; Tiago Rondão; José Sereno; Ângela Neves; Miguel Lino; Andreia Ribeiro; Antero J. Abrunhosa; Lino S. Ferreira. "A positron-emission tomography (PET)/magnetic resonance imaging (MRI) platform to track in vivo small extracellular vesicles". Nanoscale 11 28 (2019): 13243-13248. https://doi.org/10.1039/C9NR02512J.
    10.1039/C9NR02512J
  12. Pinho, S.L.C.; Sereno, J.; Abrunhosa, A.J.; Delville, M.-H.; Rocha, J.; Carlos, L.D.; Geraldes, C.F.G.C.. "Gd- A nd Eu-Loaded Iron Oxide@Silica Core-Shell Nanocomposites as Trimodal Contrast Agents for Magnetic Resonance Imaging and Optical Imaging". Inorganic Chemistry 58 24 (2019): 16618-16628. http://www.scopus.com/inward/record.url?eid=2-s2.0-85076411572&partnerID=MN8TOARS.
    10.1021/acs.inorgchem.9b02655
  13. Chiquita, S.; Ribeiro, M.; Castelhano, J.; Oliveira, F.; Sereno, J.; Batista, M.; Abrunhosa, A.; et al. "A longitudinal multimodal in vivo molecular imaging study of the 3xTg-AD mouse model shows progressive early hippocampal and taurine loss". Human Molecular Genetics 28 13 (2019): 2174-2188. http://www.scopus.com/inward/record.url?eid=2-s2.0-85068494943&partnerID=MN8TOARS.
    10.1093/hmg/ddz045
  14. Banerjee, A.; Alves, V.; Rondão, T.; Sereno, J.; Neves, Â.; Lino, M.; Ribeiro, A.; Abrunhosa, A.J.; Ferreira, L.S.. "A positron-emission tomography (PET)/magnetic resonance imaging (MRI) platform to track: In vivo small extracellular vesicles". Nanoscale 11 28 (2019): 13243-13248. http://www.scopus.com/inward/record.url?eid=2-s2.0-85069194725&partnerID=MN8TOARS.
    10.1039/c9nr02512j
  15. Banerjee, Arnab; Alves, Vitor; Rondão, Tiago; Sereno, José; Neves, Ângela; Lino, Miguel; Ribeiro, Andreia; Abrunhosa, Antero; Ferreira, Lino. "A positron-emission tomography (PET)/magnetic resonance imaging (MRI) platform to track in vivo small extracellular vesicles". (2019): http://hdl.handle.net/10316/87318.
  16. Carlos F. D. Rodrigues; Eurico Serrano; Maria I. Patrício; Mariana M. Val; Patrícia Albuquerque; João Fonseca; Célia M. F. Gomes; et al. "Stroma-derived IL-6, G-CSF and Activin-A mediated dedifferentiation of lung carcinoma cells into cancer stem cells". Scientific Reports 8 1 (2018): https://doi.org/10.1038/s41598-018-29947-w.
    10.1038/s41598-018-29947-w
  17. Joana F Guerreiro; Vítor Alves; Antero Abrunhosa; António Paulo; Octávia Monteiro Gil; F Mendes. "Radiobiological Characterization of 64CuCl2 as a Simple Tool for Prostate Cancer Theranostics". Molecules (2018): http://www.mdpi.com/1420-3049/23/11/2944.
    10.3390/molecules23112944
  18. Vítor Alves; Sergio JC do Carmo; Francisco José Cerqueira Alves; Antero Abrunhosa. "Automated Purification of Radiometals Produced by Liquid Targets". Instruments (2018): http://www.mdpi.com/2410-390X/2/3/17.
    10.3390/instruments2030017
  19. Daniela I. Paiva-Oliveira; Sara R. Martins-Neves; Antero J. Abrunhosa; Carlos Fontes-Ribeiro; Célia M. F. Gomes. "Therapeutic potential of the metabolic modulator Metformin on osteosarcoma cancer stem-like cells". Cancer Chemotherapy and Pharmacology (2018): https://doi.org/10.1007/s00280-017-3467-6.
    10.1007/s00280-017-3467-6
  20. Oliveira, F.; Leuzy, A.; Castelhano, J.; Chiotis, K.; Hasselbalch, S.G.; Rinne, J.; Mendonça, A.; et al. "Data driven diagnostic classification in Alzheimer's disease based on different reference regions for normalization of PiB-PET images and correlation with CSF concentrations of Aß species". NeuroImage: Clinical 20 (2018): 603-610. http://www.scopus.com/inward/record.url?eid=2-s2.0-85052649302&partnerID=MN8TOARS.
    10.1016/j.nicl.2018.08.023
  21. Oliveira, F.P.M.; Moreira, A.P.; De Mendonça, A.; Verdelho, A.; Xavier, C.; Barroca, D.; Rio, J.; et al. "Can 11 C-PiB-PET relative delivery R 1 or 11 C-PiB-PET perfusion replace 18 F-FDG-PET in the assessment of brain neurodegeneration?". Journal of Alzheimer's Disease 65 1 (2018): 89-97. http://www.scopus.com/inward/record.url?eid=2-s2.0-85051843086&partnerID=MN8TOARS.
    10.3233/JAD-180274
  22. Oliveira, Francisco P.M.; Moreira, Ana Paula; De Mendonça, Alexandre; Verdelho, Ana; Xavier, Carolina; Barroca, Dalila; Rio, Joana; et al. "Can 11C-PiB-PET relative delivery R1 or 11C-PiB-PET perfusion replace 18F-FDG-PET in the assessment of brain neurodegeneration?". (2018): http://hdl.handle.net/10451/36409.
    10.3233/JAD-180274
  23. Abrunhosa, Antero. "Deconstructing cancer stem cells: IL-6, G-CSF and Activin-A as mediators of stroma-orchestrated epithelial cells’ dedifferentiation". Cancer Research 77 13 Supplem (2017): 1915-1915. https://doi.org/10.1158%2F1538-7445.am2017-1915.
    10.1158/1538-7445.am2017-1915
  24. Abrunhosa, Antero. "Production of copper-64 and gallium-68 with a medical cyclotron using liquid targets". Modern Physics Letters A (2017):
    http://www.worldscientific.com/doi/abs/10.1142/S0217732317400132
  25. Oliveira-Santos M; Castelo-Branco M; Silva R; Gomes A; Chichorro N; Abrunhosa A; Donato P; et al. "Atherosclerotic plaque metabolism in high cardiovascular risk subjects - A subclinical atherosclerosis imaging study with 18F-NaF PET-CT.". (2017): http://europepmc.org/abstract/med/28349887.
    10.1016/j.atherosclerosis.2017.03.014
  26. Palma E; Mendes F; Morais GR; Rodrigues I; Santos IC; Campello MP; Raposinho P; et al. "Biophysical characterization and antineoplastic activity of new bis(thiosemicarbazonato) Cu(II) complexes.". (2017): http://europepmc.org/abstract/med/27907865.
    10.1016/j.jinorgbio.2016.11.026
  27. Ferreira MJ; Oliveira-Santos M; Silva R; Gomes A; Ferreira N; Abrunhosa A; Lima J; et al. "Assessment of atherosclerotic plaque calcification using F18-NaF PET-CT.". (2017): http://europepmc.org/abstract/med/28070735.
    10.1007/s12350-016-0776-9
  28. Do Carmo, S.J.C.; Alves, V.H.P.; Alves, F.; Abrunhosa, A.J.. "Fast and cost-effective cyclotron production of61Cu using anatZn liquid target: An opportunity for radiopharmaceutical production and R&D". Dalton Transactions 46 42 (2017): 14556-14560. http://www.scopus.com/inward/record.url?eid=2-s2.0-85032646302&partnerID=MN8TOARS.
    10.1039/c7dt01836c
  29. Alves, F.; Alves, V.H.P.; Do Carmo, S.J.C.; Neves, A.C.B.; Silva, M.; Abrunhosa, A.J.. "Production of copper-64 and gallium-68 with a medical cyclotron using liquid targets". Modern Physics Letters A 32 17 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85019686668&partnerID=MN8TOARS.
    10.1142/S0217732317400132
  30. Gonçalves, J.; Violante, I.R.; Sereno, J.; Leitão, R.A.; Cai, Y.; Abrunhosa, A.; Silva, A.P.; Silva, A.J.; Castelo-Branco, M.. "Testing the excitation/inhibition imbalance hypothesis in a mouse model of the autism spectrum disorder: In vivo neurospectroscopy and molecular evidence for regional phenotypes". Molecular Autism 8 1 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85029603049&partnerID=MN8TOARS.
    10.1186/s13229-017-0166-4
  31. S. J. C. do Carmo; V. H. P. Alves; F. Alves; A. J. Abrunhosa. "Fast and cost-effective cyclotron production of 61Cu using a natZn liquid target: an opportunity for radiopharmaceutical production and R&D". Dalton Transactions 46 42 (2017): 14556-14560. https://doi.org/10.1039/C7DT01836C.
    10.1039/C7DT01836C
  32. Antero J Abrunhosa; Vitor Hugo Alves; Angela Neves; Carmo Sergio JC do; Benoit Nactergal; Vincent Hellas; Erik Kral; Cristiana Gameiro-Paris; Francisco Alves. "Production of 68Ga in a mid-energy cyclotron: the solution is in the target". Endocrine Abstracts (2016): https://doi.org/10.1530%2Fendoabs.47.oc49.
    10.1530/endoabs.47.oc49
  33. Violante IR; Patricio M; Bernardino I; Rebola J; Abrunhosa AJ; Ferreira N; Castelo-Branco M. "GABA deficiency in NF1: A multimodal [11C]-flumazenil and spectroscopy study.". (2016): http://europepmc.org/abstract/med/27473134.
    10.1212/wnl.0000000000003044
  34. Radchenko V; Engle JW; Roy C; Griswold J; Nortier MF; Birnbaum ER; Brugh M; et al. "18th European Symposium on Radiopharmacy and Radiopharmaceuticals: Salzburg, Austria. 7-10 April 2016.". EJNMMI radiopharmacy and chemistry (2016): http://europepmc.org/abstract/PMC/PMC5843810.
    10.1186/s41181-016-0012-6
  35. Martins-Neves SR; Paiva-Oliveira DI; Wijers-Koster PM; Abrunhosa AJ; Fontes-Ribeiro C; Bovée JV; Cleton-Jansen AM; Gomes CM. "Chemotherapy induces stemness in osteosarcoma cells through activation of Wnt/ß-catenin signaling.". (2016): http://europepmc.org/abstract/med/26577806.
    10.1016/j.canlet.2015.11.013
  36. Violante, I.R.; Patricio, M.; Bernardino, I.; Rebola, J.; Abrunhosa, A.J.; Ferreira, N.; Castelo-Branco, M.. "GABA deficiency in NF1". Neurology 87 9 (2016): 897-904. http://www.scopus.com/inward/record.url?eid=2-s2.0-84984801008&partnerID=MN8TOARS.
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  37. Nuno P. F. Gonçalves; Ana V. C. Simões; Artur R. Abreu; Antero J. Abrunhosa; Janusz M. Dabrowski; Mariette M. Pereira. "Synthesis and biological distribution study of a new carbon-11 labeled porphyrin for PET imaging. Photochemical and biological characterization of the non-labeled porphyrin". Journal of Porphyrins and Phthalocyanines 19 08 (2015): 946-955. https://doi.org/10.1142%2Fs1088424615500728.
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  38. Goncalves, N.P.F.; Simões, A.V.C.; Abreu, A.R.; Abrunhosa, A.J.; Dabrowski, J.M.; Pereira, M.M.. "Synthesis and biological distribution study of a new carbon-11 labeled porphyrin for PET imaging. Photochemical and biological characterization of the non-labeled porphyrin". Journal of Porphyrins and Phthalocyanines 19 8 (2015): 946-955. http://www.scopus.com/inward/record.url?eid=2-s2.0-84940055201&partnerID=MN8TOARS.
    10.1142/S1088424615500728
  39. Goreti Ribeiro Morais; Elisa Palma; Fernanda Marques; Lurdes Gano; Maria Cristina Oliveira; Antero Abrunhosa; Hugo Vicente Miranda; et al. "Synthesis and Biological Evaluation of Novel 2-Aryl Benzimidazoles as Chemotherapeutic Agents". Journal of Heterocyclic Chemistry 54 1 (2015): 255-267. https://doi.org/10.1002%2Fjhet.2575.
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  41. Appelberg, R.; Moreira, D.; Barreira-Silva, P.; Borges, M.; Silva, L.; Dinis-Oliveira, R.J.; Resende, M.; et al. "The Warburg effect in mycobacterial granulomas is dependent on the recruitment and activation of macrophages by interferon-¿". Immunology 145 4 (2015): 498-507. http://www.scopus.com/inward/record.url?eid=2-s2.0-84936175105&partnerID=MN8TOARS.
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  42. Alves, V.H.; Prata, M.I.M.; Abrunhosa, A.J.; Castelo-Branco, M.. "GMP production of 68Ga-labelled DOTA-NOC on IBA Synthera". Journal of Radioanalytical and Nuclear Chemistry 305 2 (2015): 501-506. http://www.scopus.com/inward/record.url?eid=2-s2.0-84937977799&partnerID=MN8TOARS.
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  43. Appelberg, Rui; Moreira, Diana; Silva, Palmira Conceição Araújo Barreira; Borges, Margarida; Silva, Letícia; Dinis-Oliveira, Ricardo Jorge; Resende, Mariana; et al. "The Warburg effect in mycobacterial granulomas is dependent on the recruitment and activation of macrophages by interferon-¿". (2015): http://hdl.handle.net/1822/40065.
    10.1111/imm.12464
  44. Ribeiro Morais G; Gano L; Kniess T; Bergmann R; Abrunhosa A; Santos I; Paulo A. "Radiosynthesis and in vivo evaluation of a ¹8F-labelled styryl-benzoxazole derivative for ß-amyloid targeting.". (2013): http://europepmc.org/abstract/med/23974304.
    10.1016/j.apradiso.2013.07.003
  45. C.F.D. Rodrigues; C.M.F. Gomes; A. Abrunhosa; M. Alves; A.M. Ribeiro; C. Monteiro; A. Paiva; I.M. Carreira; M.C. Alpoim. "473 Hexavalent Chromium, Cancer Stem Cells and Dedifferentiation –a View to a Kill!". European Journal of Cancer 48 (2012): S114-S114. https://doi.org/10.1016%2Fs0959-8049%2812%2971146-2.
    10.1016/s0959-8049(12)71146-2
  46. Martins-Neves SR; Lopes ÁO; do Carmo A; Paiva AA; Simões PC; Abrunhosa AJ; Gomes CM. "Therapeutic implications of an enriched cancer stem-like cell population in a human osteosarcoma cell line.". (2012): http://europepmc.org/abstract/med/22475227.
    10.1186/1471-2407-12-139
  47. Fernandes, E.; Barbosa, Z.; Clemente, G.; Alves, F.; Abrunhosa, A.J.. "Positron emitting tracers in pre-clinical drug development". Current Radiopharmaceuticals 5 2 (2012): 90-98. http://www.scopus.com/inward/record.url?eid=2-s2.0-84857135421&partnerID=MN8TOARS.
    10.2174/1874471011205020090
  48. Gomes CM; Abrunhosa AJ; Ramos P; Pauwels EK. "Molecular imaging with SPECT as a tool for drug development.". (2011): http://europepmc.org/abstract/med/20933557.
    10.1016/j.addr.2010.09.015
  49. Gomes, C.M.F.; Abrunhosa, A.J.; Pauwels, E.K.J.. "Molecular imaging with SPECT and PET in exploratory investigational new drug studies". Drugs of the Future 36 1 (2011): 69-77. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955995627&partnerID=MN8TOARS.
    10.1358/dof.2011.36.1.1507257
  50. Gomes, C.M.F.; Abrunhosa, A.J.; Pauwels, E.K.J.. "Molecular imaging with SPECT and PET in exploratory investigational new drug studies". Drugs of the Future 36 1 (2011): 69-77. http://www.scopus.com/inward/record.url?eid=2-s2.0-84952981021&partnerID=MN8TOARS.
    10.1358/dof.2011.036.01.1507257
  51. Botelho MF; Marques MA; Gomes C; da Silva AM; Bairos V; Santos Rosa MA; Abrunhosa AP; de Lima JJ. "Nanoradioliposomes molecularly modulated to study the lung deep lymphatics drainage.". (2010): http://europepmc.org/abstract/med/25965698.
    10.1016/s0873-2159(15)30083-0
  52. Neves SR; Lopes AO; do Carmo A; Abrunhosa AJ; Simões PC; Paiva AA; Botelho MF; Gomes CM. "Osteosarcoma contains a subpopulation of cancer stem-like cells that are highly resistant to radiotherapy.". (2010): http://europepmc.org/abstract/PMC/PMC3255038.
  53. Gomes CM; Abrunhosa AJ; Pauwels EK; Botelho MF. "P-glycoprotein versus MRP1 on transport kinetics of cationic lipophilic substrates: a comparative study using [99mTc]sestamibi and [99mTc]tetrofosmin.". (2009): http://europepmc.org/abstract/med/19409044.
    10.1089/cbr.2008.0539
  54. Maria Filomena Rabaça Roque Botelho; Maria Alcide Tavares Marques; Célia Maria Freitas Gomes; Augusto Marques Ferreira da Silva; Vasco António Andrade Figueiredo Bairos; Manuel Amaro de Matos Santos Rosa; Antero Pena Abrunhosa; João José Pedroso de Lima. "Nanorradiolipossomas modulados molecularmente para estudar a drenagem linfática pulmonar profunda". Revista Portuguesa de Pneumologia 15 2 (2009): 261-293. https://doi.org/10.1016%2Fs0873-2159%2815%2930131-8.
    10.1016/s0873-2159(15)30131-8
  55. Botelho, M.F.R.R.; Marques, M.A.T.; Gomes, C.M.F.; da Silva, A.M.F.; Bairos, V.A.A.F.; Rosa, M.A. de M.S.; Abrunhosa, A.P.; de Lima, J.J.P.. "Nanoradioliposomes molecularly modulated to study the lung deep lymphatic drainage | Nanorradiolipossomas modulados molecularmente para estudar a drenagem linfática pulmonar profunda". Revista Portuguesa de Pneumologia 15 2 (2009): 261-293. http://www.scopus.com/inward/record.url?eid=2-s2.0-67650327279&partnerID=MN8TOARS.
    10.1016/S0873-2159(15)30131-8
  56. Botelho,Maria Filomena Rabaça Roque; Marques,Maria Alcide Tavares; Gomes,Célia Maria Freitas; Silva,Augusto Marques Ferreira da; Bairos,Vasco António Andrade Figueiredo; Rosa,Manuel Amaro de Matos Santos; Abrunhosa,Antero Pena; Lima,João José Pedroso de. "Nanoradioliposomes molecularly modulated to study the lung deep lymphatic drainage". (2009): http://www.scielo.mec.pt/scielo.php?script=sci_arttext&pid=S0873-21592009000200009.
  57. Gomes CM; Welling M; Que I; Henriquez NV; van der Pluijm G; Romeo S; Abrunhosa AJ; et al. "Functional imaging of multidrug resistance in an orthotopic model of osteosarcoma using 99mTc-sestamibi.". (2007): http://europepmc.org/abstract/med/17541583.
    10.1007/s00259-007-0480-8
  58. Gomes CM; van Paassen H; Romeo S; Welling MM; Feitsma RI; Abrunhosa AJ; Botelho MF; et al. "Multidrug resistance mediated by ABC transporters in osteosarcoma cell lines: mRNA analysis and functional radiotracer studies.". (2006): http://europepmc.org/abstract/med/17045162.
    10.1016/j.nucmedbio.2006.07.011
  59. Zeevaart JR; Jansen DR; Botelho MF; Abrunhosa A; Gomes C; Metello L; Kolar ZI; et al. "Comparison of the predicted in vivo behaviour of the Sn(II)-APDDMP complex and the results as studied in a rodent model.". (2004): http://europepmc.org/abstract/med/15337604.
    10.1016/j.jinorgbio.2004.06.004
  60. Santos RM; Barbosa RM; Antunes CM; Silva AM; Salgado AP; Abrunhosa AJ; Pereira FC; Seiça RM; Rosário LM. "Bursting electrical activity generated in the presence of KATP channel blockers. Pharmacology, sensitivity to intracellular pH and modulation by glucose metabolism.". (1997): http://europepmc.org/abstract/med/9544253.
  61. Rosário, L.M.; Barbosa, R.M.; Antunes, C.M.; Silva, A.M.; Abrunhosa, A.J.; Santos, R.M.. "Bursting electrical activity in pancreatic ß-cells: evidence that the channel underlying the burst is sensitive to Ca2+ influx through L-type Ca2+ channels". Pflügers Archiv European Journal of Physiology 424 5-6 (1993): 439-447. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027282069&partnerID=MN8TOARS.
    10.1007/BF00374906
Capítulo de livro
  1. Alves, V.H.; Abrunhosa, A.J.; Castelo-Branco, M.. "Synthesis of (R)-[N-Methyl-11C]PK11195". 93-101. 2015.
Livro
  1. Santos, R.M.; Barbosa, R.M.; Antunes, C.M.; Silva, A.M.; Salgado, A.P.; Abrunhosa, A.J.; Pereira, F.C.; Seiça, R.M.; Rosário, L.M.. Bursting electrical activity generated in the presence of KATP channel blockers: Pharmacology, sensitivity to intracellular pH and modulation by glucose metabolism. 1997.
Tese / Dissertação
  1. Rodrigues, Iolanda Beatriz Albuquerque. "Synthesis Optimisation of High Specific Activity Carbon-11 Radiopharmaceuticals for Brain PET Studies". Mestrado, 2020. http://hdl.handle.net/10316/90183.
  2. Fonseca, Alexandra Isabel Simões. "Labelling and validation of [61Cu]DOTA-NOC for somatostatin receptors imaging". Mestrado, 2019. http://hdl.handle.net/10316/87934.
  3. Cruz, Ângela Cristina Simões. "Investigação de um detetor não-invasivo para determinar a função de entrada em estudos PET quantitativos". Mestrado, 2018. http://hdl.handle.net/10400.26/23180.
  4. Catarino, Ana Rita. "Selective internal radiation therapy: review of the standard operating procedure for selective internal radiation therapy using SIR-Spheres microspheres labelled with Yttrium 90". Mestrado, 2017. http://hdl.handle.net/10400.26/22708.
  5. Vintém, João Paulo Nogueira, 1991-. "Desenvolvimento de um modelo dosimétrico baseado em medidas de área". Mestrado, 2015. http://hdl.handle.net/10400.26/14512.
  6. Simões, Ana Vanessa Cordeiro. "Síntese de macrociclos tetrapirrólicos fluorados. Desenvolvimento de potenciais marcadores para tomografia por emissão de positrões". Doutoramento, 2014. http://hdl.handle.net/10316/25271.
  7. Barroca, Dalila. "Estudo combinado de PET com [11C]PiB e [18F]FDG na avaliação de doença de Alzheimer". Mestrado, 2014. http://hdl.handle.net/10400.26/14488.
  8. Serra, Cristina. "Optimização e Validação da Produção de [13n]-Nh3 para Estudos Clínicos de Tomografia por Emissão de Positrões na Avaliação da Perfusão Miocárdica". Mestrado, 2014. http://hdl.handle.net/10400.22/5725.
  9. Rio, Joana Maria Teixeira Espinheira. "Importância da [11C]-Racloprida no diagnóstico de Síndromes Parkinsónicos com tomografia por emissão de positrões (PET)". Mestrado, 2014. http://hdl.handle.net/10400.26/17038.
  10. Clemente, Gonçalo dos Santos. "Synthesis of optimization of [11C] Pittsburgh compound B by the captive solvent method". Mestrado, 2013. http://hdl.handle.net/10400.21/2314.
  11. Moreira, Hugo Manuel Ramos. "Cyclotron Production of 68Ga using a 68Zn-based liquid target". Mestrado, 2013. http://hdl.handle.net/10316/32456.
  12. Alves, Vítor Hugo Pereira. "Optimisation of synthesis, purification and reformulation of (R)-[N-methyl-¹¹C] PK11195 for in vivo PET imaging studies". Mestrado, 2012. http://hdl.handle.net/10316/26005.
  13. Abrunhosa, Antero José Pena Afonso de. "Métodos computacionais no desenvolvimento de radiofármacos para a tomografia por emissão de positrões.". Doutoramento, 2002. http://hdl.handle.net/10316/810.

Outros

Outra produção
  1. Pereira A; Lopes L; Fonte P; Póvoa P; Santos TG; Martinho A; Neves Â; et al. 2020. Prototype of an affordable pressure-controlled emergency mechanical ventilator for COVID-19. http://europepmc.org/abstract/PPR/PPR270077.
  2. Vítor H. Alves; Antero J. Abrunhosa; Miguel Castelo-Branco. 2015. Synthesis of (R)-[N-Methyl-11C]PK11195. https://doi.org/10.1002%2F9781118834114.ch10.
    10.1002/9781118834114.ch10
  3. A.J. Abrunhosa; F. Brady; S. Luthra; J.J. De Lima; T. Jones. 2001. Preliminary Studies of Computer Aided Ligand Design for PET. https://doi.org/10.1016%2Fb978-012285751-5%2F50011-9.
    10.1016/b978-012285751-5/50011-9
  4. A.J. Abrunhosa; F. Brady; S.K. Luthra; H. Morris; J.J. De Lima; T. Jones. 1998. Use of Information Technology in the Search for New PET Tracers. https://doi.org/10.1016%2Fb978-012161340-2%2F50042-1.
    10.1016/b978-012161340-2/50042-1
Atividades

Orientação

Título / Tema
Papel desempenhado
Curso (Tipo)
Instituição / Organização
2020 - 2020 Synthesis Optimisation of High Specific Activity Carbon-11 Radiopharmaceuticals for Brain PET Studies
Orientador
Engenharia Biomédica (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2019 - 2019 Labelling and validation of [61Cu]DOTA-NOC for somatostatin receptors imaging
Orientador
Bioquímica (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2016 - 2016 Production and purification of radiometals for theranostics via liquid targets in a medical cyclotron
Orientador
Engenharia Biomédica (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2014 - 2014 Novos biomarcadores morfométricos do cerebelo por ressonância magnética: validação na doença de Machado-Joseph
Coorientador
Ciências da Saúde (Doutoramento)
Universidade de Coimbra Faculdade de Medicina, Portugal
Distinções

Outra distinção

2008 Robalo Cordeiro Award
Sociedade Portuguesa de Pneumologia, Portugal
1999 Young Investigator Award
Society of Nuclear Medicine and Molecular Imaging, Estados Unidos
1997 Honourable mention of the Scientific Committee
Society of Nuclear Medicine and Molecular Imaging, Estados Unidos