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Maria Rangel (MR) is an Associate Professor at Instituto de Ciências Biomédicas de Abel Salazar of University of Porto. Has been responsible for courses on Chemical Biology, Thermodynamics, Biophysical Chemistry and Structural Analysis. MR supervised the work of several Post-Doctoral, Ph.D., M.Sc. and Project Students. MR is a Bioinorganic Chemist whose domains of specialization are Inorganic and Physical Chemistry. MR has large experience in Coordination Chemistry and Spectroscopy. Since her Ph. D. MR has worked in the area of coordination chemistry and has acquired expertise in synthesis and characterization of transition metal complexes. She has developed a strong theoretical and experimental expertise on EPR Spectroscopy and X-ray Absorption Spectroscopy and a very good experience on other spectroscopic methods like NMR, Electronic Absorption and Fluorescence Spectroscopy, FTIR and MS which have been used mostly as characterization tools. MR research interests are focused in the role of metal ions in living organisms and, in the recent years she has worked on the design of Iron chelators for: (a) novel strategies to fight Infection through Fe deprivation; (b) treatment of Fe Overload and (c) Fe Sensing. Her interest in Iron Biology has been extended to Plant Nutrition. MR is currently developing projects that aim the understanding of mineral nutrition processes and design of Fe-chelates to address agricultural problems related with Fe deficiency. The development of insulin-like vanadium and zinc complexes and B12 model compounds are two topics that have also been explored in previous years. Maria Rangel has been Principal Investigator of several multidisciplinary projects and has a considerable experience in coordinating teams developing research on the interfaces of chemistry and biology. At present she is Head of Chemistry Department (ICBAS), Co-Director of the Integrated Master Course of Bioengineering; Co-Director of the Master Course of Bioengineering; Co-Director of the BSc Course of Bioengineering; Member of the Scientific and Technical Board of REQUIMTE and Scientist in charge of the NMR and EPR Laboratories of UPORTO.
Identificação

Identificação pessoal

Nome completo
Maria Rangel

Nomes de citação

  • Rangel, Maria

Identificadores de autor

Ciência ID
2E18-5B36-29C0
ORCID iD
0000-0002-0998-1437
AuthenticusID
R-000-ARW
Researcher Id
B-3732-2012
Scopus Author Id
55963098900

Endereços de correio eletrónico

  • mrangel@icbas.up.pt (Profissional)
  • mcrangel@fc.up.pt (Profissional)

Telefones

Telefone
  • 220428337 (Profissional)

Moradas

  • Instituto Ciências Biomédicas Abel Salazar, Universidade do Porto. Rua Jorge Viterbo Ferreira, 228, 4050-313, PORTO, Porto, Portugal (Profissional)

Websites

Domínios de atuação

  • Ciências Exatas - Química - Química Inorgânica
  • Ciências Agrárias
  • Ciências Naturais - Ciências Biológicas - Biofísica

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Francês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Formação
Grau Classificação
2011
Concluído
Agregação em Ciências Biomédicas (Título de Agregado)
Especialização em Ciências Biomédicas
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
""n/a"" (TESE/DISSERTAÇÃO)
Aprovado por unanimidade
1989
Concluído
Doutoramento em Ciências Biomédicas (Doutoramento)
Especialização em Ciências Biomédicas (Química)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
"Aplicação da Espectroscopia de Ressonância de Spin Electrónico ao Estudos dos Produtos de Fotólise de Compostos Modelo da VItamina B12" (TESE/DISSERTAÇÃO)
Aprovado com distinção e louvor
1978
Concluído
Licenciatura em Química-Ramo Científico-Especialidade de Química Física e Inorgânica (Licenciatura)
Universidade do Porto Faculdade de Ciências, Portugal
""n/a"" (TESE/DISSERTAÇÃO)
16 valores
1976/07
Concluído
Bacharelato em Química (Bacharelato)
Universidade do Porto, Portugal
Percurso profissional

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento
Empregador
1992/02/23 - Atual Professor Associado (Docente Universitário) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
1989/10/03 - 1992/02/22 Professor Auxiliar (Docente Universitário) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
1980/10/01 - 1989/10/01 Assistente (Docente Universitário) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
1978/10/01 - 1980/09/30 Assistente Estagiário (Docente Universitário) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
1978/04/01 - 1978/09/01 Monitor (Docente Universitário) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Cargos e Funções

Categoria Profissional
Instituição de acolhimento
Empregador
2022/02/14 - Atual Head of Chemistry Department Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2021 - Atual Co-Diretor da Licenciatura em Bioengenharia Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2021 - Atual Co-Diretor do Mestrado em Bioengenharia Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2015/09/28 - Atual Co-Diretor do Mestrado Integrado em Bioengenharia Universidade do Porto, Portugal
2015/09/28 - Atual Membro da Comissão Científica do Mestrado Integrado em Bioengenharia Universidade do Porto, Portugal
2015/09/28 - Atual Membro da Comissão de Acompanhamento do Mestrado Integrado em Bioengenharia Universidade do Porto, Portugal
2002 - Atual Membro da Comissão Científica e Técnica do REQUIMTE REQUIMTE LAQV Porto, Portugal
REQUIMTE LAQV Porto, Portugal
2013 - 2014 Conselho científico/técnico-científico ou orgão correspondente Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
Projetos

Projeto

Designação Financiadores
2016/06 - 2019/11 (Fe)rrying plants to prevent chlorosis
PTDC/AGRPRO/3515/2014
Fundação para a Ciência e a Tecnologia

Outro

Designação Financiadores
2022/01/01 - 2023/06/01 Cellulose-based iron nanofertilizers for sustainable growth of soybean plants.
EXPL/QUI-QIN/0411/2021
Investigador
REQUIMTE LAQV Porto, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2019/11/01 - 2022/10/31 Fluorecent chelators for metal ion sensing in water.
PTDC/QUI-QIN/28142/2017
Investigador
Universidade Católica Portuguesa, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2018/07/01 - 2021/06/30 Polyphenols in Art: chemistry and biology hand in hand with conservation of cultural heritage
PTDC/QUI-OUT/29925/2017
Investigador
Associação para a Inovação e Desenvolvimento da FCT, Portugal

Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2018/06/01 - 2021/05/31 Xanthene-based optical sensors
PTDC/QUI-QOR/29426/2017
Investigador
Universidade de Aveiro, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2016/06/01 - 2019/11/30 (Fe)rrying plants to prevent chlorosis
PTDC/AGRPRO/3515/2014
Investigador responsável
REQUIMTE LAQV Porto, Portugal
Concluído
2013/07/01 - 2015/12/31 EnvIRONsensing - Novel iron sensing systems for biogeochemical applications
PTDC/AAG-MAA/3978/2012
Investigador
Universidade Católica Portuguesa, Portugal

Universidade do Porto Instituto de Ciências e Tecnologias Agrárias e Agro-Alimentares, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2011/04/01 - 2014/09/30 Protection from iron toxicity by the immune system: cells, proteins and mechanisms
PTDC/SAU-MET/113011/2009
Investigador
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Universidade do Porto Instituto de Ciências e Tecnologias Agrárias e Agro-Alimentares, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2009/01/02 - 2012/06/30 Novel Key Molecular Architectures to Target Infection
PTDC/QUI/67915/2006
Investigador responsável
Universidade do Porto Instituto de Ciências e Tecnologias Agrárias e Agro-Alimentares, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2005/01/01 - 2008/06/30 Design of macromolecular intracellular iron chelators and evaluation of their anti-microbial activity
POCI/QUI/56214/2004
Investigador responsável
REQUIMTE LAQV Porto, Portugal

Universidade do Porto Instituto de Ciências e Tecnologias Agrárias e Agro-Alimentares, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2005/10/01 - 2007/06/30 Design of new Vanadium compounds: towards their application as anti-diabetic and anti-cancer agents
POCI/QUI/56949/2004
Investigador
Universidade de Lisboa Instituto Superior Técnico, Portugal

Universidade de Lisboa Centro de Química Estrutural, Portugal

Universidade do Porto Instituto de Ciências e Tecnologias Agrárias e Agro-Alimentares, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2002 - 2004 Estudo de Factores Estruturais Determinantes na Reactividade dos Produtos de Fotólise de Compostos Modelo do Sistema B12
POCTI/QUI/46231/2002
Investigador responsável
Universidade do Porto Faculdade de Ciências, Portugal
Concluído
Produções

Publicações

Artigo em revista
  1. Carla Queirós; Sílvia Vinhas; Jéssica Oliveira; Andreia Leite; Ana M. G. Silva; Maria Rangel. "Functionalization of Rhodamine Platforms with 3-Hydroxy-4-pyridinone Chelating Units and Its Fluorescence Behavior towards Fe(III)". Molecules (2022): https://www.mdpi.com/1420-3049/27/5/1567.
    10.3390/molecules27051567
  2. Moreira, MIF; Almeida, J; Leite, A; Ferreira, AIMCL; Santos, LMNBF; Silva, AMG; Rangel, M. "Ohmic heating-assisted synthesis and characterization of Zn(ii), Cu(ii) and Pd(ii) complexes of heterocyclic-fused chlorins". DALTON TRANSACTIONS (2022):
    10.1039/d1dt04032d
  3. Mesquita, Raquel B. R.; Moniz, Tânia; Nunes, Maria J. M.; Mesquita, Letícia S.; Rangel, Maria; Rangel, António O. S. S.. "Sequential injection method for bi-parametric determination of iron and manganese in soil leachates". Analytical Methods 14 2 (2022): 180-187. http://dx.doi.org/10.1039/d1ay01932e.
    Publicado • 10.1039/d1ay01932e
  4. Aníbal Silva; Carla Queirós; Andreia Leite; María T. Rodríguez; María J. Rojo; Tomás Torroba; Rui C. Martins; Ana M. G. Silva; Maria Rangel. "Synthesis of Catechol Derived Rosamine Dyes and Their Reactivity toward Biogenic Amines". Molecules (2021): https://www.mdpi.com/1420-3049/26/16/5082.
    10.3390/molecules26165082
  5. Santos, C.S.; Rodrigues, E.; Ferreira, S.; Moniz, T.; Leite, A.; Carvalho, S.M.P.; Vasconcelos, M.W.; Rangel, M.. "Foliar application of 3-hydroxy-4-pyridinone Fe-chelate [Fe(mpp)3] induces responses at the root level amending iron deficiency chlorosis in soybean". Physiologia Plantarum 173 1 (2021): 235-245. http://www.scopus.com/inward/record.url?eid=2-s2.0-85102427959&partnerID=MN8TOARS.
    10.1111/ppl.13367
  6. Silva, A.M.N.; Moniz, T.; de Castro, B.; Rangel, M.. "Human transferrin: An inorganic biochemistry perspective". Coordination Chemistry Reviews 449 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85114843974&partnerID=MN8TOARS.
    10.1016/j.ccr.2021.214186
  7. Loureiro, DRP; Soares, JX; Maia, A; Silva, AMN; Rangel, M; Azevedo, CMG; Hansen, SV; et al. "One-Pot Synthesis of Xanthone by Carbonylative Suzuki Coupling Reaction". CHEMISTRYSELECT (2021):
    10.1002/slct.202101394
  8. Vargas, A.P.; Almeida, J.; Gámez, F.; Roales, J.; Queirós, C.; Rangel, M.; Lopes-Costa, T.; Silva, A.M.G.; Pedrosa, J.M.. "Synthesis of a highly emissive carboxylated pyrrolidine-fused chlorin for optical sensing of TATP vapours". Dyes and Pigments 195 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85112767542&partnerID=MN8TOARS.
    10.1016/j.dyepig.2021.109721
  9. Almeida, J; Zhang, GY; Wang, MD; Queiros, C; Cerqueira, AFR; Tome, AC; Barone, G; et al. "Synthesis, characterization, and cellular investigations of porphyrin-and chlorin-indomethacin conjugates for photodynamic therapy of cancer". ORGANIC & BIOMOLECULAR CHEMISTRY (2021):
    10.1039/d1ob01015h
  10. Ribas, Tânia C.F.; Mesquita, Raquel B.R.; Moniz, Tânia; Rangel, Maria; Rangel, António O.S.S.. "Greener and wide applicability range flow-based spectrophotometric method for iron determination in fresh and marine water". Talanta 216 (2020): 120925. http://dx.doi.org/10.1016/j.talanta.2020.120925.
    10.1016/j.talanta.2020.120925
  11. Moniz, Tânia; Bassett, Chelsea R.; Almeida, M. Inês G.S.; Kolev, Spas D.; Rangel, Maria; Mesquita, Raquel B.R.. "Use of an ether-derived 3-hydroxy-4-pyridinone chelator as a new chromogenic reagent in the development of a microfluidic paper-based analytical device for Fe(III) determination in natural waters". Talanta 214 (2020): 120887. http://dx.doi.org/10.1016/j.talanta.2020.120887.
    10.1016/j.talanta.2020.120887
  12. Mesquita, Letícia S.; Mesquita, Raquel B. R.; Leite, Andreia; Moniz, Tânia; Rangel, Maria; Rangel, António O. S. S.. "Integrated Flow-based System Displaying an In-line Mini Soil Column to Monitor Iron Species in Soils Leachates". Communications in Soil Science and Plant Analysis (2020): 1-12. http://dx.doi.org/10.1080/00103624.2020.1751186.
    10.1080/00103624.2020.1751186
  13. Nabais, P.; Oliveira, J.; Pina, F.; Teixeira, N.; de Freitas, V.; Brás, N. F.; Clemente, A.; et al. "A 1000-year-old mystery solved: Unlocking the molecular structure for the medieval blue from Chrozophora tinctoria, also known as folium". Science Advances 6 16 (2020): eaaz7772. http://dx.doi.org/10.1126/sciadv.aaz7772.
    10.1126/sciadv.aaz7772
  14. Santos, CS; Leite, A; Vinhas, S; Ferreira, S; Moniz, T; Vasconcelos, MW; Rangel, M. "A combined physiological and biophysical approach to understand the ligand-dependent efficiency of 3-hydroxy-4-pyridinone Fe-chelates". PLANT DIRECT (2020):
    10.1002/pld3.256
  15. Moniz, T; Cunha Silva, L; Mesquita, RBR; Miranda, JLA; Silva, AMN; Silva, AMG; Rangel, AOSS; de Castro, B; Rangel, M. "New hydrophilic 3-hydroxy-4-pyridinone chelators with ether-derived substituents: Synthesis and evaluation of analytical performance in the determination of iron in waters". POLYHEDRON (2019):
    10.1016/j.poly.2018.12.005
  16. Miranda, JLA; Mesquita, RBR; Nunes, A; Rangel, M; Rangel, AOSS. "Determination of iron(III) in water samples by microsequential injection solid phase spectrometry using an hexadentate 3-hydroxy-4-pyridinone chelator as reagent". TALANTA (2019):
    10.1016/j.talanta.2018.08.063
  17. Leite, A; Cunha Silva, L; Silva, D; Ferreira, AIMCL; Santos, LMNBF; Cardoso, ICS; Silva, VLM; Rangel, M; Silva, AMG. "Synthesis of Pyridyl and N-Methylpyridinium Analogues of Rosamines: Relevance of Solvent and Charge on Their Photophysical Properties". CHEMISTRY-A EUROPEAN JOURNAL (2019):
    10.1002/chem.201903313
  18. Leite, A; Bessa, LJ; Silva, AMG; Gameiro, P; de Castro, B; Rangel, M. "Antibacterial activity of naphthyl derived bis-(3-hydroxy-4-pyridinonate) copper(II) complexes against multidrug-resistant bacteria". JOURNAL OF INORGANIC BIOCHEMISTRY (2019):
    10.1016/j.jinorgbio.2019.110704
  19. Rebelo, SLH; Moniz, T; Medforth, CJ; de Castro, B; Rangel, M. "EPR spin trapping studies of H2O2 activation in metaloporphyrin catalyzed oxygenation reactions: Insights on the biomimetic mechanism". MOLECULAR CATALYSIS (2019):
    10.1016/j.mcat.2019.110500
  20. Coimbra, JTS; Bras, NF; Fernandes, PA; Rangel, M; Ramos, MJ. "A computational study on the redox properties and binding affinities of iron complexes of hydroxypyridinones". JOURNAL OF MOLECULAR MODELING (2019):
    10.1007/s00894-019-4037-0
  21. Almeida, J; Fortuna, ME; Pricop, L; Lobiuc, A; Leite, A; Silva, AMN; Monteiro, RP; et al. "(Aminophenyl)porphyrins as precursors for the synthesis of porphyrin-modified siloxanes". JOURNAL OF PORPHYRINS AND PHTHALOCYANINES (2019):
    10.1142/s1088424619500573
  22. Maria Rangel; Tânia Moniz; Silva A. M. N.; Andreia Leite. "Tuning the Anti(myco)bacterial Activity of 3-Hydroxy-4-pyridinone Chelators through Fluorophores". Pharmaceuticals (2018): http://www.mdpi.com/1424-8247/11/4/110.
    10.3390/ph11040110
  23. Silva, AMN; Coimbra, JTS; Castro, MM; Oliveira, A; Bras, NF; Fernandes, PA; Ramos, MJ; Rangel, M. "Determining the glycation site specificity of human holo-transferrin". JOURNAL OF INORGANIC BIOCHEMISTRY (2018):
    10.1016/j.jinorgbio.2018.05.016
  24. Coimbra, JTS; Bras, NF; Fernandes, PA; Rangel, M; Ramos, MJ. "Membrane partition of bis-(3-hydroxy-4pyridinonato) zinc(ii) complexes revealed by molecular dynamics simulations". RSC ADVANCES (2018):
    10.1039/c8ra03602k
  25. Almeida, J; Silva, AMN; Rebelo, SLH; Cunha Silva, L; Rangel, M; de Castro, B; Leite, A; Silva, AMG. "Synthesis and coordination studies of 5-(4 '-carboxyphenyl)-10,15,20-tris(pentafluorophenyl) porphyrin and its pyrrolidine-fused chlorin derivative". NEW JOURNAL OF CHEMISTRY (2018):
    10.1039/c7nj05165d
  26. Ferreira, S; Leite, A; Moniz, T; Andrade, M; Amaral, L; de Castro, B; Rangel, M. "EPR and V-51 NMR studies of prospective anti-diabetic bis(3-hydroxy-4-pyridinonato) oxidovanadium(IV) complexes in aqueous solution and liposome suspensions". NEW JOURNAL OF CHEMISTRY (2018):
    10.1039/c7nj04678b
  27. Novais, A; Moniz, T; Rebelo, AR; Silva, AMG; Rangel, M; Peixe, L. "New fluorescent rosamine chelator showing promising antibacterial activity against Gram-positive bacteria". BIOORGANIC CHEMISTRY (2018):
    10.1016/j.bioorg.2018.05.013
  28. Moniz, T; Feio, M; Silva, D; de Castro, B; Rangel, M. "Study of the effect of thiourea and N-ethyl groups on antibacterial activity of rhodamine-labeled 3,4-HPO iron chelators against Gram ( plus /-) bacteria". MEDICINAL CHEMISTRY RESEARCH (2018):
    10.1007/s00044-018-2165-1
  29. Queirós, C.; Leite, A.; Cunha-Silva, L.; de Castro, B.; Rangel, M.; Sousaraei, A.; Cabanillas-Gonzalez, J.; et al. "Synthesis and characterization of two fluorescent isophthalate rosamines: From solution to immobilization in solid substrates". Dyes and Pigments 157 (2018): 405-414. http://www.scopus.com/inward/record.url?eid=2-s2.0-85047511709&partnerID=MN8TOARS.
    10.1016/j.dyepig.2018.05.005
  30. Moniz, T.; Dias Da Silva, D.; Carmo, H.; De Castro, B.; De Lourdes Bastos, M.; Rangel, M.. "Insights on the relationship between structure vs. toxicological activity of antibacterial rhodamine-labelled 3-hydroxy-4-pyridinone iron(III) chelators in HepG2 cells". Interdisciplinary Toxicology 11 3 (2018): 189-199. http://www.scopus.com/inward/record.url?eid=2-s2.0-85074514686&partnerID=MN8TOARS.
    10.2478/intox-2018-0016
  31. da Conceição Rangel, Maria; Vasconcelos, Marta. "(Fe)rrying plants to prevent chlorosis". Impact 2017 11 (2017): 79-81. http://dx.doi.org/10.21820/23987073.2017.11.79.
    10.21820/23987073.2017.11.79
  32. Patil, Amit; Lande, Dipali N.; Nalkar, Archana; Gejji, Shridhar P.; Chakrovorty, Debamitra; Gonnade, Rajesh; Moniz, Tania; et al. "Binding selectivity of vitamin K3 based chemosensors towards nickel(II) and copper(II) metal ions". Journal of Molecular Structure 1143 (2017): 495-514. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000403122700057&KeyUID=WOS:000403122700057.
    10.1016/j.molstruc.2017.04.094
  33. Rocha, Jefferson A.; Andrade, Ivanilza M.; Veras, Leiz M. C.; Quelemes, Patrick V.; Lima, David F.; Soares, Maria J. S.; Pinto, Pedro L. S.; et al. "Anthelmintic, Antibacterial and Cytotoxicity Activity of Imidazole Alkaloids from Pilocarpus microphyllus Leaves". Phytotherapy Research 31 4 (2017): 624-630. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000398604300007&KeyUID=WOS:000398604300007.
    10.1002/ptr.5771
  34. Gonzalez, Alba; Mesquita, Raquel B. R.; Avivar, Jessica; Moniz, Tania; Rangel, Maria; Cerda, Victor; Rangel, Antonio O. S. S.. "Microsequential injection lab-on-valve system for the spectrophotometric bi-parametric determination of iron and copper in natural waters". Talanta 167 (2017): 703-708. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000399511600089&KeyUID=WOS:000399511600089.
    10.1016/j.talanta.2017.02.055
  35. Almeida, Jose; Aguiar, Antonio; Leite, Andreia; Silva, Andre M. N.; Cunha-Silva, Luis; de Castro, Baltazar; Rangel, Maria; et al. "1,3-Dipolar cycloadditions with meso-tetraarylchlorins - site selectivity and mixed bisadducts". Organic Chemistry Frontiers 4 4 (2017): 534-544. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000398911900008&KeyUID=WOS:000398911900008.
    10.1039/c6qo00771f
  36. Moniz, T.; Leite, A.; Silva, T.; Gameiro, P.; Gomes, M. S.; de Castro, B.; Rangel, M.. "The influence of functional groups on the permeation and distribution of antimycobacterial rhodamine chelators". Journal of Inorganic Biochemistry 175 (2017): 138-147. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000411919000015&KeyUID=WOS:000411919000015.
    10.1016/j.jinorgbio.2017.07.017
  37. Soares, Jose Xavier; Alves, Emanuele Amorim; Silva, Andre M. N.; de Figueiredo, Natalia Guimaraes; Neves, Joao F.; Cravo, Sara Manuela; Rangel, Maria; et al. "Street-Like Synthesis of Krokodil Results in the Formation of an Enlarged Cluster of Known and New Morphinans". Chemical Research in Toxicology 30 8 (2017): 1609-1621. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000408302900010&KeyUID=WOS:000408302900010.
    10.1021/acs.chemrestox.7b00126
  38. Cotton, Sofia; Azevedo, Rita; Gaiteiro, Cristiana; Ferreira, Dylan; Lima, Luis; Peixoto, Andreia; Fernandes, Elisabete; et al. "Targeted O-glycoproteomics explored increased sialylation and identified MUC16 as a poor prognosis biomarker in advanced-stage bladder tumours". Molecular Oncology 11 8 (2017): 895-912. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000406633900001&KeyUID=WOS:000406633900001.
    10.1002/1878-0261.12035
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  90. Burgess, J.; Parsons, S.A.; Singh, K.; Waltham, E.; López, P.; Sánchez, F.; Rangel, M.; Schlindwein, W.. "Ruthenium complexes of 3-hydroxy-4-pyranones and of 3-hydroxy-4-pyridinones". Transition Metal Chemistry 33 5 (2008): 553-561. http://www.scopus.com/inward/record.url?eid=2-s2.0-45849083849&partnerID=MN8TOARS.
    10.1007/s11243-008-9079-6
  91. Neves, P.; Leite, A.; Rangel, M.; De Castro, B.; Gameiro, P.. "Influence of structural factors on the enhanced activity of moxifloxacin: A fluorescence and EPR spectroscopic study". Analytical and Bioanalytical Chemistry 387 4 (2007): 1543-1552. http://www.scopus.com/inward/record.url?eid=2-s2.0-33846863822&partnerID=MN8TOARS.
    10.1007/s00216-006-1009-x
  92. Schlindwein, W.; Waltham, E.; Burgess, J.; Binsted, N.; Nunes, A.; Leite, A.; Rangel, M.. "New lipophilic 3-hydroxy-4-pyridinonate iron(III) complexes: Synthesis and EXAFS structural characterisation". Dalton Transactions 6 10 (2006): 1313-1321. http://www.scopus.com/inward/record.url?eid=2-s2.0-33644551227&partnerID=MN8TOARS.
    10.1039/b509671e
  93. Rangel, M.; Leite, A.; Amorim, M.J.; Garribba, E.; Micera, G.; Lodyga-Chruscinska, E.. "Spectroscopic and potentiometric characterization of oxovanadium(IV) complexes formed by 3-hydroxy-4-pyridinones. Rationalization of the influence of basicity and electronic structure of the ligand on the properties of V IVO species in aqueous solution". Inorganic Chemistry 45 20 (2006): 8086-8097. http://www.scopus.com/inward/record.url?eid=2-s2.0-33750383413&partnerID=MN8TOARS.
    10.1021/ic0605571
  94. Rangel, M.; Leite, A.; Gomes, J.; De Castro, B.. "Photolysis secondary products of cobaloximes and imino/oxime compounds controlled by steric hindrance imposed by the Lewis base". Organometallics 24 14 (2005): 3500-3507. http://www.scopus.com/inward/record.url?eid=2-s2.0-22444437631&partnerID=MN8TOARS.
    10.1021/om0580046
  95. Castro, M.M.C.A.; Avecilla, F.; Geraldes, C.F.G.C.; De Castro, B.; Rangel, M.. "Study of the oxidation products of the VO(dmpp)2 complex in aqueous solution under aerobic conditions: Comparison with the vanadate-dmpp system". Inorganica Chimica Acta 356 (2003): 142-154. http://www.scopus.com/inward/record.url?eid=2-s2.0-1042286391&partnerID=MN8TOARS.
    10.1016/S0020-1693(03)00473-0
  96. Rehder, D.; Pessoa, J.C.; Geraldes, C.F.G.C.; Castro, M.M.C.A.; Kabanos, T.; Kiss, T.; Meier, B.; et al. "Erratum: In vitro study of the insulin-mimetic behaviour of vanadium(IV, V) coordination compounds (Journal of Biological Inorganic Chemistry (2002) 7 (384-396))". Journal of Biological Inorganic Chemistry 7 6 (2002): http://www.scopus.com/inward/record.url?eid=2-s2.0-0036937457&partnerID=MN8TOARS.
    10.1007/s00775-002-0372-0
  97. Rehder, D.; Costa Pessoa, J.; Geraldes, C.F.G.C.; Castro, M.M.C.A.; Kabanos, T.; Kiss, T.; Meier, B.; et al. "In vitro study of the insulin-mimetic behaviour of vanadium(IV, V) coordination compounds". Journal of Biological Inorganic Chemistry 7 4-5 (2002): 384-396. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036941223&partnerID=MN8TOARS.
    10.1007/s00775-001-0311-5
  98. Rangel, M.; Pereira, E.; Oliveira, C.; De Castro, B.. "Characterization of the photolysis products of sec-butylcobaloximes with imidazole and benzimidazole bases". Journal of Organometallic Chemistry 632 1-2 (2001): 85-93. http://www.scopus.com/inward/record.url?eid=2-s2.0-0041869425&partnerID=MN8TOARS.
    10.1016/S0022-328X(01)00854-3
  99. Rangel, M.; Tamura, A.; Fukushima, C.; Sakurai, H.. "In vitro study of the insulin-like action of vanadyl-pyrone and -pyridinone complexes with a VO(O4) coordination mode". Journal of Biological Inorganic Chemistry 6 2 (2001): 128-132. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034839962&partnerID=MN8TOARS.
    10.1007/s007750000180
  100. Rangel, M.. "Pyridinone oxovanadium(IV) complexes: a new class of insulin mimetic compounds". Transition Metal Chemistry 26 1-2 (2001): 219-223. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035253235&partnerID=MN8TOARS.
    10.1023/A:1007130400129
  101. Castro, M.M.C.A.; Geraldes, C.F.G.C.; Gameiro, P.; Pereira, E.; Castro, B.; Rangel, M.. "Structural study of the interaction of vanadate with the ligand 1,2-dimethyl-3-hydroxy-4-pyridinone (Hdmpp) in aqueous solution". Journal of Inorganic Biochemistry 80 1-2 (2000): 177-179. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034732841&partnerID=MN8TOARS.
    10.1016/s0162-0134(00)00028-3
  102. Rangel, M.; Arcos, T.; De Castro, B.. "Photolysis Primary Products of Alkylcobaloximes Controlled by the Cobalt-Carbon Bond Strength". Organometallics 18 17 (1999): 3451-3456. http://www.scopus.com/inward/record.url?eid=2-s2.0-0001321794&partnerID=MN8TOARS.
    10.1021/om990078s
  103. Schlindwein, W; Rangel, M; Burgess, J. "XAFS studies of pyranone and pyridinone metal(III) complexes". JOURNAL OF SYNCHROTRON RADIATION (1999):
    10.1107/s0909049598016525
  104. Rangel, M.; Pereira-Lima, L.; Waechter, F.L.. "The value of the left cholangiojejunostomy in the palliative treatment for malignant obstruction of the hepatic hilus,LA VALEUR DE LA CHOLANGIO-JEJUNOSTOMIE GAUCHE DANS LE TRAITEMENT PALLIATIF DE L'OBSTRUCTION MALIGNE DU HILE HEPATIQUE". Journal de Chirurgie 134 9-10 (1997): 401-405. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031408510&partnerID=MN8TOARS.
  105. Burgess, J.; De Castro, S.; Oliveira, C.; Rangel, M.; Schlindwein, W.. "Synthesis and characterization of 3-hydroxy-4-pyridinone-oxovanadium(IV) complexes". Polyhedron 16 5 (1996): 789-794. http://www.scopus.com/inward/record.url?eid=2-s2.0-0000686681&partnerID=MN8TOARS.
    10.1016/s0277-5387(96)00343-9
  106. Burgess, J.; De Castro, B.; Oliveira, C.; Rangel, M.. "Synthesis and Characterization of Some 1-Aryl-3-hydroxypyridin-4(1H)-ones. Solubilities and their Solvation in Methanol-Water Mixtures". Journal of Chemical Research - Part S 5 (1996): 234-235. http://www.scopus.com/inward/record.url?eid=2-s2.0-2742564168&partnerID=MN8TOARS.
  107. Arcos, T.; De Castro, B.; Ferreira, M.J.; Rangel, M.; Raynor, J.B.. "Electron spin resonance study of the cobalt(II) species formed after room-temperature photolysis of aqua(sec-butyl)bis(dimethylglyoximato)cobalt(III) in the presence of N-donor bases". Journal of the Chemical Society, Dalton Transactions 3 (1994): 369-377. http://www.scopus.com/inward/record.url?eid=2-s2.0-37049080028&partnerID=MN8TOARS.
    10.1039/DT9940000369
  108. De Castro, B.; Pereira, J.; Rangel, M.. "EPR characterization of the photolysis and thermolysis products of alkylcobaloximes with symmetric phosphines and phosphites. Factors that stabilize the cobalt homolysis fragments". Organometallics 10 11 (1991): 3848-3855. http://www.scopus.com/inward/record.url?eid=2-s2.0-2542514123&partnerID=MN8TOARS.
    10.1021/om00057a014
  109. De Castro, B.; Rangel, M.; Raynor, J.B.. "An electron spin resonance spectral study of bis(dimethylglyoximato)-cobalt(II) and some phosphine and phosphite adducts". Journal of the Chemical Society, Dalton Transactions 11 (1990): 3311-3318. http://www.scopus.com/inward/record.url?eid=2-s2.0-37049081072&partnerID=MN8TOARS.
    10.1039/DT9900003311
  110. Da Silva, M.A.V.R.; Da Silva, M.D.M.C.R.; Rangel, M.C.S.S.; Pilcher, G.; Akello, M.J.; Carson, A.S.; Jamea, E.H.. "Mean copper-ligand binding enthalpies in copper(II) complexes of dimethylglyoxime, glycine, acetic acid and 4-phenylamino-3-penten-2-one". Thermochimica Acta 160 2 (1990): 267-280. http://www.scopus.com/inward/record.url?eid=2-s2.0-4243224106&partnerID=MN8TOARS.
    10.1016/0040-6031(90)80266-2
Capítulo de livro
  1. Burgess, John; Rangel, Maria. "Hydroxypyranones, hydroxypyridinones, and their complexes". In Advances in Inorganic Chemistry, 167-243. Elsevier, 2008.
    10.1016/s0898-8838(08)00005-6
Resumo em conferência
  1. Rangel, M; Vinhas, S; Ivanova, G; Lopes, S; Ferreira, S. "NMR Study of Partition and Permeation Properties of Ga(III) Chelates". 2019.
    10.1016/j.bpj.2018.11.2753
  2. Alves, EA; Soares, JX; Silva, AM; Neves, JF; Cravo, SM; Rangel, M; Afonso, CM; et al. "identification of a complex mixture of opioids on krokodil street-like samples". 2016.
    10.1016/j.toxlet.2016.06.2039
  3. Ponte, F; Fraga, S; Moniz, T; da Silva, DD; Carvalho, F; Carmo, H; Remiao, F; Rangel, M; Bastos, ML. "Development of insulino-mimetic zinc(II) complexes of the class 3-hydroxy-4-pyridinone ligands: In vitro cytotoxicity studies for safety assessment". 2014.
    10.1016/j.toxlet.2014.06.226
  4. Rangel, M; Moniz, T; Leite, A; Gameiro, P. "Tagging 3-Hydroxy-4-Pyridinone Iron Chelators with Rhodamine B Derivatives is Essential to Target Mycobacterium Avium Infection". 2013.
  5. Moniz, T; Gomes, MS; Rangel, M. "RHODAMINE LABELING OF 3-HYDROXY-4-PYRIDINONE IRON CHELATORS IS AN IMPORTANT CONTRIBUTION TO TARGET MYCOBACTERIUM AVIUM INFECTION". 2013.
  6. Rangel, M; Moniz, T; Leite, A; Gameiro, P; Ivanova, G. "FLUORESCENT IRON CHELATORS WITH ANTIMICROBIAL ACTIVITY: INSIGHT ON STRUCTURE-ACTIVITY RELATIONSHIPS FROM LIPOSOME PARTITION STUDIES". 2013.
  7. Rangel, M; Gameiro, P; Leite, A; Nunes, A; Zhou, T; Ma, YM; Hider, R. "Insight on the Diverse Cellular Pathways of Two Novel Chelators from Liposome Partition Studies". 2009.
  8. Rangel, M; Nunes, A; Leite, A; Gameiro, P; Castro, B. "Fluorescence studies on a novel iron(III) chelator with anti-microbial activity". 2007.
  9. Rangel, M; Pinto, R; Gameiro, P; Pereira, E; Castro, B; Burgess, J. "Study of the interaction of vanadyl ion with the ligand 1,2-dimethyl-3-hydroxy-4-pyridinone". 2001.
Atividades

Orientação

Título / Tema
Papel desempenhado
Curso (Tipo)
Instituição / Organização
2012/01/01 - 2016/05/04 Design of novel 3-hydroxy-4-pyridinone iron chelators to fight mycobacterium infection
Orientador
Química Sustentável (Doutoramento)
Universidade do Porto Faculdade de Ciências, Portugal
2014 - 2015 Estudos em solução de complexos de vanádio com 3-hidroxi-4-piridinonas com potencial insulino-mimético
Orientador
Bioengenharia (Mestrado)
Universidade do Porto Faculdade de Engenharia, Portugal
2006/01 - 2011/12 Design de ligandos quelantes multifuncionalizados derivados de 3,4-hidroxipiridinonas
Orientador
Chemistry (Doutoramento)
Universidade do Porto Faculdade de Ciências, Portugal
2009/09 - 2010/10 Characterization of the anti-bacterial activity of the recently found iron chelator CP777 against Micobacterium avium
Coorientador
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2005 - 2009/09 Non-Transferrin Bound Iron: understanding the chemical nature of the species
Coorientador
2007 - 2007 Sistemas Miméticos de Biomembranas na Caracterização da Interacção, a Nível Molecular, de Quinolonas com a Proteína Membranar Ompf
Coorientador
Química (Doutoramento)
Universidade do Porto Faculdade de Ciências, Portugal
2003 - 2007 Síntese de Compostos Multi-funcionalizados Derivados de 3- Hidroxi-4-piridinonas com Potencial Aplicação Terapêutica e Como Sondas Intracelulares
Orientador
Química (Doutoramento)
Universidade do Porto Faculdade de Ciências, Portugal
2003 - 2004 Synthesis and characterization of metal complexes with potential insulinmimetic behaviour
Orientador
Chemistry (Mestrado)
Universidade do Porto Faculdade de Ciências, Portugal

Membro de associação

Nome da associação Tipo de participação
2015 - Atual Royal Society of Chemistry Member
2015 - Atual International Society for the Study of Iron in Biology and Medicine
2011 - Atual Sociedade Portuguesa de Química Member
2006 - Atual American Chemical Society Member
2006 - Atual Biophysical Society Member
2016 - 2018 Sociedade Portuguesa de Química-Presidente da Divisão de Química Inorgânica e Bioinorgânica