Maria Rangel (MR) is an Associate Professor at Instituto de Ciências Biomédicas de Abel Salazar of University of Porto. Has been responsible for courses on Chemical Biology, Thermodynamics, Biophysical Chemistry and Structural Analysis. MR supervised the work of several Post-Doctoral, Ph.D., M.Sc. and Project Students. MR is a Bioinorganic Chemist whose domains of specialization are Inorganic and Physical Chemistry. MR has large experience in Coordination Chemistry and Spectroscopy. Since her Ph. D. MR has worked in the area of coordination chemistry and has acquired expertise in synthesis and characterization of transition metal complexes. She has developed a strong theoretical and experimental expertise on EPR Spectroscopy and X-ray Absorption Spectroscopy and a very good experience on other spectroscopic methods like NMR, Electronic Absorption and Fluorescence Spectroscopy, FTIR and MS which have been used mostly as characterization tools. MR research interests are focused in the role of metal ions in living organisms and, in the recent years she has worked on the design of Iron chelators for: (a) novel strategies to fight Infection through Fe deprivation; (b) treatment of Fe Overload and (c) Fe Sensing. Her interest in Iron Biology has been extended to Plant Nutrition. MR is currently developing projects that aim the understanding of mineral nutrition processes and design of Fe-chelates to address agricultural problems related with Fe deficiency. The development of insulin-like vanadium and zinc complexes and B12 model compounds are two topics that have also been explored in previous years. Maria Rangel has been Principal Investigator of several multidisciplinary projects and has a considerable experience in coordinating teams developing research on the interfaces of chemistry and biology. At present she is Head of Chemistry Department (ICBAS), Co-Director of the Integrated Master Course of Bioengineering; Co-Director of the Master Course of Bioengineering; Co-Director of the BSc Course of Bioengineering; Member of the Scientific and Technical Board of REQUIMTE and Scientist in charge of the NMR and EPR Laboratories of UPORTO.

Identificação pessoal

Nome completo
Maria Rangel

Nomes de citação

  • Rangel, Maria

Identificadores de autor

Ciência ID
Researcher Id
Scopus Author Id

Endereços de correio eletrónico

  • mrangel@icbas.up.pt (Profissional)
  • mcrangel@fc.up.pt (Profissional)


  • 220428337 (Profissional)


  • Instituto Ciências Biomédicas Abel Salazar, Universidade do Porto. Rua Jorge Viterbo Ferreira, 228, 4050-313, PORTO, Porto, Portugal (Profissional)


Domínios de atuação

  • Ciências Exatas - Química - Química Inorgânica
  • Ciências Agrárias
  • Ciências Naturais - Ciências Biológicas - Biofísica


Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Francês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Grau Classificação
Agregação em Ciências Biomédicas (Título de Agregado)
Especialização em Ciências Biomédicas
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
Aprovado por unanimidade
Doutoramento em Ciências Biomédicas (Doutoramento)
Especialização em Ciências Biomédicas (Química)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
"Aplicação da Espectroscopia de Ressonância de Spin Electrónico ao Estudos dos Produtos de Fotólise de Compostos Modelo da VItamina B12" (TESE/DISSERTAÇÃO)
Aprovado com distinção e louvor
Licenciatura em Química-Ramo Científico-Especialidade de Química Física e Inorgânica (Licenciatura)
Universidade do Porto Faculdade de Ciências, Portugal
16 valores
Bacharelato em Química (Bacharelato)
Universidade do Porto, Portugal
Percurso profissional

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento
1992/02/23 - Atual Professor Associado (Docente Universitário) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
1989/10/03 - 1992/02/22 Professor Auxiliar (Docente Universitário) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
1980/10/01 - 1989/10/01 Assistente (Docente Universitário) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
1978/10/01 - 1980/09/30 Assistente Estagiário (Docente Universitário) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
1978/04/01 - 1978/09/01 Monitor (Docente Universitário) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Cargos e Funções

Categoria Profissional
Instituição de acolhimento
2022/02/14 - Atual Head of Chemistry Department Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2021 - Atual Co-Diretor da Licenciatura em Bioengenharia Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2021 - Atual Co-Diretor do Mestrado em Bioengenharia Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2015/09/28 - Atual Co-Diretor do Mestrado Integrado em Bioengenharia Universidade do Porto, Portugal
2015/09/28 - Atual Membro da Comissão Científica do Mestrado Integrado em Bioengenharia Universidade do Porto, Portugal
2015/09/28 - Atual Membro da Comissão de Acompanhamento do Mestrado Integrado em Bioengenharia Universidade do Porto, Portugal
2002 - Atual Membro da Comissão Científica e Técnica do REQUIMTE REQUIMTE LAQV Porto, Portugal
REQUIMTE LAQV Porto, Portugal
2013 - 2014 Conselho científico/técnico-científico ou orgão correspondente Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal


Designação Financiadores
2016/06 - 2019/11 (Fe)rrying plants to prevent chlorosis
Fundação para a Ciência e a Tecnologia


Designação Financiadores
2022/01/01 - 2023/06/01 Cellulose-based iron nanofertilizers for sustainable growth of soybean plants.
REQUIMTE LAQV Porto, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2019/11/01 - 2022/10/31 Fluorecent chelators for metal ion sensing in water.
Universidade Católica Portuguesa, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2018/07/01 - 2021/06/30 Polyphenols in Art: chemistry and biology hand in hand with conservation of cultural heritage
Associação para a Inovação e Desenvolvimento da FCT, Portugal

Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2018/06/01 - 2021/05/31 Xanthene-based optical sensors
Universidade de Aveiro, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2016/06/01 - 2019/11/30 (Fe)rrying plants to prevent chlorosis
Investigador responsável
REQUIMTE LAQV Porto, Portugal
2013/07/01 - 2015/12/31 EnvIRONsensing - Novel iron sensing systems for biogeochemical applications
Universidade Católica Portuguesa, Portugal

Universidade do Porto Instituto de Ciências e Tecnologias Agrárias e Agro-Alimentares, Portugal
Fundação para a Ciência e a Tecnologia
2011/04/01 - 2014/09/30 Protection from iron toxicity by the immune system: cells, proteins and mechanisms
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Universidade do Porto Instituto de Ciências e Tecnologias Agrárias e Agro-Alimentares, Portugal
Fundação para a Ciência e a Tecnologia
2009/01/02 - 2012/06/30 Novel Key Molecular Architectures to Target Infection
Investigador responsável
Universidade do Porto Instituto de Ciências e Tecnologias Agrárias e Agro-Alimentares, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
Fundação para a Ciência e a Tecnologia
2005/01/01 - 2008/06/30 Design of macromolecular intracellular iron chelators and evaluation of their anti-microbial activity
Investigador responsável
REQUIMTE LAQV Porto, Portugal

Universidade do Porto Instituto de Ciências e Tecnologias Agrárias e Agro-Alimentares, Portugal
Fundação para a Ciência e a Tecnologia
2005/10/01 - 2007/06/30 Design of new Vanadium compounds: towards their application as anti-diabetic and anti-cancer agents
Universidade de Lisboa Instituto Superior Técnico, Portugal

Universidade de Lisboa Centro de Química Estrutural, Portugal

Universidade do Porto Instituto de Ciências e Tecnologias Agrárias e Agro-Alimentares, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
2002 - 2004 Estudo de Factores Estruturais Determinantes na Reactividade dos Produtos de Fotólise de Compostos Modelo do Sistema B12
Investigador responsável
Universidade do Porto Faculdade de Ciências, Portugal


Artigo em revista
  1. Carla Queirós; Sílvia Vinhas; Jéssica Oliveira; Andreia Leite; Ana M. G. Silva; Maria Rangel. "Functionalization of Rhodamine Platforms with 3-Hydroxy-4-pyridinone Chelating Units and Its Fluorescence Behavior towards Fe(III)". Molecules (2022): https://www.mdpi.com/1420-3049/27/5/1567.
  2. Moreira, MIF; Almeida, J; Leite, A; Ferreira, AIMCL; Santos, LMNBF; Silva, AMG; Rangel, M. "Ohmic heating-assisted synthesis and characterization of Zn(ii), Cu(ii) and Pd(ii) complexes of heterocyclic-fused chlorins". DALTON TRANSACTIONS (2022):
  3. Mesquita, Raquel B. R.; Moniz, Tânia; Nunes, Maria J. M.; Mesquita, Letícia S.; Rangel, Maria; Rangel, António O. S. S.. "Sequential injection method for bi-parametric determination of iron and manganese in soil leachates". Analytical Methods 14 2 (2022): 180-187. http://dx.doi.org/10.1039/d1ay01932e.
    Publicado • 10.1039/d1ay01932e
  4. Aníbal Silva; Carla Queirós; Andreia Leite; María T. Rodríguez; María J. Rojo; Tomás Torroba; Rui C. Martins; Ana M. G. Silva; Maria Rangel. "Synthesis of Catechol Derived Rosamine Dyes and Their Reactivity toward Biogenic Amines". Molecules (2021): https://www.mdpi.com/1420-3049/26/16/5082.
  5. Santos, C.S.; Rodrigues, E.; Ferreira, S.; Moniz, T.; Leite, A.; Carvalho, S.M.P.; Vasconcelos, M.W.; Rangel, M.. "Foliar application of 3-hydroxy-4-pyridinone Fe-chelate [Fe(mpp)3] induces responses at the root level amending iron deficiency chlorosis in soybean". Physiologia Plantarum 173 1 (2021): 235-245. http://www.scopus.com/inward/record.url?eid=2-s2.0-85102427959&partnerID=MN8TOARS.
  6. Silva, A.M.N.; Moniz, T.; de Castro, B.; Rangel, M.. "Human transferrin: An inorganic biochemistry perspective". Coordination Chemistry Reviews 449 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85114843974&partnerID=MN8TOARS.
  7. Loureiro, DRP; Soares, JX; Maia, A; Silva, AMN; Rangel, M; Azevedo, CMG; Hansen, SV; et al. "One-Pot Synthesis of Xanthone by Carbonylative Suzuki Coupling Reaction". CHEMISTRYSELECT (2021):
  8. Vargas, A.P.; Almeida, J.; Gámez, F.; Roales, J.; Queirós, C.; Rangel, M.; Lopes-Costa, T.; Silva, A.M.G.; Pedrosa, J.M.. "Synthesis of a highly emissive carboxylated pyrrolidine-fused chlorin for optical sensing of TATP vapours". Dyes and Pigments 195 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85112767542&partnerID=MN8TOARS.
  9. Almeida, J; Zhang, GY; Wang, MD; Queiros, C; Cerqueira, AFR; Tome, AC; Barone, G; et al. "Synthesis, characterization, and cellular investigations of porphyrin-and chlorin-indomethacin conjugates for photodynamic therapy of cancer". ORGANIC & BIOMOLECULAR CHEMISTRY (2021):
  10. Ribas, Tânia C.F.; Mesquita, Raquel B.R.; Moniz, Tânia; Rangel, Maria; Rangel, António O.S.S.. "Greener and wide applicability range flow-based spectrophotometric method for iron determination in fresh and marine water". Talanta 216 (2020): 120925. http://dx.doi.org/10.1016/j.talanta.2020.120925.
  11. Moniz, Tânia; Bassett, Chelsea R.; Almeida, M. Inês G.S.; Kolev, Spas D.; Rangel, Maria; Mesquita, Raquel B.R.. "Use of an ether-derived 3-hydroxy-4-pyridinone chelator as a new chromogenic reagent in the development of a microfluidic paper-based analytical device for Fe(III) determination in natural waters". Talanta 214 (2020): 120887. http://dx.doi.org/10.1016/j.talanta.2020.120887.
  12. Mesquita, Letícia S.; Mesquita, Raquel B. R.; Leite, Andreia; Moniz, Tânia; Rangel, Maria; Rangel, António O. S. S.. "Integrated Flow-based System Displaying an In-line Mini Soil Column to Monitor Iron Species in Soils Leachates". Communications in Soil Science and Plant Analysis (2020): 1-12. http://dx.doi.org/10.1080/00103624.2020.1751186.
  13. Nabais, P.; Oliveira, J.; Pina, F.; Teixeira, N.; de Freitas, V.; Brás, N. F.; Clemente, A.; et al. "A 1000-year-old mystery solved: Unlocking the molecular structure for the medieval blue from Chrozophora tinctoria, also known as folium". Science Advances 6 16 (2020): eaaz7772. http://dx.doi.org/10.1126/sciadv.aaz7772.
  14. Santos, CS; Leite, A; Vinhas, S; Ferreira, S; Moniz, T; Vasconcelos, MW; Rangel, M. "A combined physiological and biophysical approach to understand the ligand-dependent efficiency of 3-hydroxy-4-pyridinone Fe-chelates". PLANT DIRECT (2020):
  15. Moniz, T; Cunha Silva, L; Mesquita, RBR; Miranda, JLA; Silva, AMN; Silva, AMG; Rangel, AOSS; de Castro, B; Rangel, M. "New hydrophilic 3-hydroxy-4-pyridinone chelators with ether-derived substituents: Synthesis and evaluation of analytical performance in the determination of iron in waters". POLYHEDRON (2019):
  16. Miranda, JLA; Mesquita, RBR; Nunes, A; Rangel, M; Rangel, AOSS. "Determination of iron(III) in water samples by microsequential injection solid phase spectrometry using an hexadentate 3-hydroxy-4-pyridinone chelator as reagent". TALANTA (2019):
  17. Leite, A; Cunha Silva, L; Silva, D; Ferreira, AIMCL; Santos, LMNBF; Cardoso, ICS; Silva, VLM; Rangel, M; Silva, AMG. "Synthesis of Pyridyl and N-Methylpyridinium Analogues of Rosamines: Relevance of Solvent and Charge on Their Photophysical Properties". CHEMISTRY-A EUROPEAN JOURNAL (2019):
  18. Leite, A; Bessa, LJ; Silva, AMG; Gameiro, P; de Castro, B; Rangel, M. "Antibacterial activity of naphthyl derived bis-(3-hydroxy-4-pyridinonate) copper(II) complexes against multidrug-resistant bacteria". JOURNAL OF INORGANIC BIOCHEMISTRY (2019):
  19. Rebelo, SLH; Moniz, T; Medforth, CJ; de Castro, B; Rangel, M. "EPR spin trapping studies of H2O2 activation in metaloporphyrin catalyzed oxygenation reactions: Insights on the biomimetic mechanism". MOLECULAR CATALYSIS (2019):
  20. Coimbra, JTS; Bras, NF; Fernandes, PA; Rangel, M; Ramos, MJ. "A computational study on the redox properties and binding affinities of iron complexes of hydroxypyridinones". JOURNAL OF MOLECULAR MODELING (2019):
  21. Almeida, J; Fortuna, ME; Pricop, L; Lobiuc, A; Leite, A; Silva, AMN; Monteiro, RP; et al. "(Aminophenyl)porphyrins as precursors for the synthesis of porphyrin-modified siloxanes". JOURNAL OF PORPHYRINS AND PHTHALOCYANINES (2019):
  22. Maria Rangel; Tânia Moniz; Silva A. M. N.; Andreia Leite. "Tuning the Anti(myco)bacterial Activity of 3-Hydroxy-4-pyridinone Chelators through Fluorophores". Pharmaceuticals (2018): http://www.mdpi.com/1424-8247/11/4/110.
  23. Silva, AMN; Coimbra, JTS; Castro, MM; Oliveira, A; Bras, NF; Fernandes, PA; Ramos, MJ; Rangel, M. "Determining the glycation site specificity of human holo-transferrin". JOURNAL OF INORGANIC BIOCHEMISTRY (2018):
  24. Coimbra, JTS; Bras, NF; Fernandes, PA; Rangel, M; Ramos, MJ. "Membrane partition of bis-(3-hydroxy-4pyridinonato) zinc(ii) complexes revealed by molecular dynamics simulations". RSC ADVANCES (2018):
  25. Almeida, J; Silva, AMN; Rebelo, SLH; Cunha Silva, L; Rangel, M; de Castro, B; Leite, A; Silva, AMG. "Synthesis and coordination studies of 5-(4 '-carboxyphenyl)-10,15,20-tris(pentafluorophenyl) porphyrin and its pyrrolidine-fused chlorin derivative". NEW JOURNAL OF CHEMISTRY (2018):
  26. Ferreira, S; Leite, A; Moniz, T; Andrade, M; Amaral, L; de Castro, B; Rangel, M. "EPR and V-51 NMR studies of prospective anti-diabetic bis(3-hydroxy-4-pyridinonato) oxidovanadium(IV) complexes in aqueous solution and liposome suspensions". NEW JOURNAL OF CHEMISTRY (2018):
  27. Novais, A; Moniz, T; Rebelo, AR; Silva, AMG; Rangel, M; Peixe, L. "New fluorescent rosamine chelator showing promising antibacterial activity against Gram-positive bacteria". BIOORGANIC CHEMISTRY (2018):
  28. Moniz, T; Feio, M; Silva, D; de Castro, B; Rangel, M. "Study of the effect of thiourea and N-ethyl groups on antibacterial activity of rhodamine-labeled 3,4-HPO iron chelators against Gram ( plus /-) bacteria". MEDICINAL CHEMISTRY RESEARCH (2018):
  29. Queirós, C.; Leite, A.; Cunha-Silva, L.; de Castro, B.; Rangel, M.; Sousaraei, A.; Cabanillas-Gonzalez, J.; et al. "Synthesis and characterization of two fluorescent isophthalate rosamines: From solution to immobilization in solid substrates". Dyes and Pigments 157 (2018): 405-414. http://www.scopus.com/inward/record.url?eid=2-s2.0-85047511709&partnerID=MN8TOARS.
  30. Moniz, T.; Dias Da Silva, D.; Carmo, H.; De Castro, B.; De Lourdes Bastos, M.; Rangel, M.. "Insights on the relationship between structure vs. toxicological activity of antibacterial rhodamine-labelled 3-hydroxy-4-pyridinone iron(III) chelators in HepG2 cells". Interdisciplinary Toxicology 11 3 (2018): 189-199. http://www.scopus.com/inward/record.url?eid=2-s2.0-85074514686&partnerID=MN8TOARS.
  31. da Conceição Rangel, Maria; Vasconcelos, Marta. "(Fe)rrying plants to prevent chlorosis". Impact 2017 11 (2017): 79-81. http://dx.doi.org/10.21820/23987073.2017.11.79.
  32. Patil, Amit; Lande, Dipali N.; Nalkar, Archana; Gejji, Shridhar P.; Chakrovorty, Debamitra; Gonnade, Rajesh; Moniz, Tania; et al. "Binding selectivity of vitamin K3 based chemosensors towards nickel(II) and copper(II) metal ions". Journal of Molecular Structure 1143 (2017): 495-514. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000403122700057&KeyUID=WOS:000403122700057.
  33. Rocha, Jefferson A.; Andrade, Ivanilza M.; Veras, Leiz M. C.; Quelemes, Patrick V.; Lima, David F.; Soares, Maria J. S.; Pinto, Pedro L. S.; et al. "Anthelmintic, Antibacterial and Cytotoxicity Activity of Imidazole Alkaloids from Pilocarpus microphyllus Leaves". Phytotherapy Research 31 4 (2017): 624-630. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000398604300007&KeyUID=WOS:000398604300007.
  34. Gonzalez, Alba; Mesquita, Raquel B. R.; Avivar, Jessica; Moniz, Tania; Rangel, Maria; Cerda, Victor; Rangel, Antonio O. S. S.. "Microsequential injection lab-on-valve system for the spectrophotometric bi-parametric determination of iron and copper in natural waters". Talanta 167 (2017): 703-708. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000399511600089&KeyUID=WOS:000399511600089.
  35. Almeida, Jose; Aguiar, Antonio; Leite, Andreia; Silva, Andre M. N.; Cunha-Silva, Luis; de Castro, Baltazar; Rangel, Maria; et al. "1,3-Dipolar cycloadditions with meso-tetraarylchlorins - site selectivity and mixed bisadducts". Organic Chemistry Frontiers 4 4 (2017): 534-544. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000398911900008&KeyUID=WOS:000398911900008.
  36. Moniz, T.; Leite, A.; Silva, T.; Gameiro, P.; Gomes, M. S.; de Castro, B.; Rangel, M.. "The influence of functional groups on the permeation and distribution of antimycobacterial rhodamine chelators". Journal of Inorganic Biochemistry 175 (2017): 138-147. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000411919000015&KeyUID=WOS:000411919000015.
  37. Soares, Jose Xavier; Alves, Emanuele Amorim; Silva, Andre M. N.; de Figueiredo, Natalia Guimaraes; Neves, Joao F.; Cravo, Sara Manuela; Rangel, Maria; et al. "Street-Like Synthesis of Krokodil Results in the Formation of an Enlarged Cluster of Known and New Morphinans". Chemical Research in Toxicology 30 8 (2017): 1609-1621. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000408302900010&KeyUID=WOS:000408302900010.
  38. Cotton, Sofia; Azevedo, Rita; Gaiteiro, Cristiana; Ferreira, Dylan; Lima, Luis; Peixoto, Andreia; Fernandes, Elisabete; et al. "Targeted O-glycoproteomics explored increased sialylation and identified MUC16 as a poor prognosis biomarker in advanced-stage bladder tumours". Molecular Oncology 11 8 (2017): 895-912. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000406633900001&KeyUID=WOS:000406633900001.
  39. Silva, Tania; Moreira, Ana C.; Nazmi, Kamran; Moniz, Tania; Vale, Nuno; Rangel, Maria; Gomes, Paula; et al. "Lactoferricin Peptides Increase Macrophages' Capacity To Kill Mycobacterium avium". Msphere 2 4 (2017): http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000408618500032&KeyUID=WOS:000408618500032.
  40. Santos, C.S.; Carvalho, S.M.P.; Leite, A.; Moniz, T.; Roriz, M.; Rangel, A.O.S.S.; Rangel, M.; Vasconcelos, M.W.. "Effect of tris(3-hydroxy-4-pyridinonate) iron(III) complexes on iron uptake and storage in soybean (Glycine max L.)". Plant Physiology and Biochemistry 106 (2016): 91-100. http://www.scopus.com/inward/record.url?eid=2-s2.0-84964901118&partnerID=MN8TOARS.
  41. Leite, A.; Silva, A.M.G.; Coutinho, C.; Cunha-Silva, L.; de Castro, B.; Rangel, M.. "Design of a Water Soluble Fluorescent 3-Hydroxy-4-Pyridinone Ligand Active at Physiological pH Values". Journal of Fluorescence 26 5 (2016): 1773-1785. http://www.scopus.com/inward/record.url?eid=2-s2.0-84976350781&partnerID=MN8TOARS.
  42. Moniz, T.; De Castro, B.; Rangel, M.; Ivanova, G.. "NMR study of the interaction of fluorescent 3-hydroxy-4-pyridinone chelators with DMPC liposomes". Physical Chemistry Chemical Physics 18 6 (2016): 5027-5033. http://www.scopus.com/inward/record.url?eid=2-s2.0-84957593723&partnerID=MN8TOARS.
  43. Peixoto, A.; Fernandes, E.; Gaiteiro, C.; Lima, L.; Azevedo, R.; Soares, J.; Cotton, S.; et al. "Hypoxia enhances the malignant nature of bladder cancer cells and concomitantly antagonizes protein O-glycosylation extension". Oncotarget 7 39 (2016): 63138-63157. http://www.scopus.com/inward/record.url?eid=2-s2.0-84994050563&partnerID=MN8TOARS.
  44. Moniz, T.; Coimbra, J.T.S.; Brás, N.F.; Cunha-Silva, L.; Ramos, M.J.; Fernandes, P.A.; De Castro, B.; Rangel, M.. "Synthesis and structural characterization, by spectroscopic and computational methods, of two fluorescent 3-hydroxy-4-pyridinone chelators bearing sulphorhodamine B and naphthalene". RSC Advances 6 5 (2016): 4200-4211. http://www.scopus.com/inward/record.url?eid=2-s2.0-84954288404&partnerID=MN8TOARS.
  45. Miranda, J.L.A.; Mesquita, R.B.R.; Nunes, A.; Rangel, M.; Rangel, A.O.S.S.. "Iron speciation in natural waters by sequential injection analysis with a hexadentate 3-hydroxy-4-pyridinone chelator as chromogenic agent". Talanta 148 (2016): 633-640. http://www.scopus.com/inward/record.url?eid=2-s2.0-84949093095&partnerID=MN8TOARS.
  46. Chisté, R.C.; Ribeiro, D.; Freitas, M.; Leite, A.; Moniz, T.; Rangel, M.; Fernandes, E.. "Uncovering novel 3-hydroxy-4-pyridinone metal ion complexes with potential anti-inflammatory properties". Journal of Inorganic Biochemistry 155 (2016): 9-16. http://www.scopus.com/inward/record.url?eid=2-s2.0-84947708390&partnerID=MN8TOARS.
  47. Moreira, A.S.P.; Coimbra, M.A.; Nunes, F.M.; Passos, C.P.; Santos, S.A.O.; Silvestre, A.J.D.; Silva, A.M.N.; Rangel, M.; Domingues, M.R.M.. "Chlorogenic acid-arabinose hybrid domains in coffee melanoidins: Evidences from a model system". Food Chemistry 185 (2015): 135-144. http://www.scopus.com/inward/record.url?eid=2-s2.0-84926681204&partnerID=MN8TOARS.
  48. Suárez, R.; Mesquita, R.B.R.; Rangel, M.; Cerdà, V.; Rangel, A.O.S.S.. "Iron speciation by microsequential injection solid phase spectrometry using 3-hydroxy-1(H)-2-methyl-4-pyridinone as chromogenic reagent". Talanta 133 (2015): 15-20. http://www.scopus.com/inward/record.url?eid=2-s2.0-84913527031&partnerID=MN8TOARS.
  49. Queirós, C.; Leite, A.; Silva, A.M.G.; Gameiro, P.; De Castro, B.; Rangel, M.. "Synthesis and spectroscopic characterization of a new tripodal hexadentate iron chelator incorporating catechol units". Polyhedron 87 (2015): 1-7. http://www.scopus.com/inward/record.url?eid=2-s2.0-84913582208&partnerID=MN8TOARS.
  50. Nunes, C.D.; Vaz, P.D.; Félix, V.; Veiros, L.F.; Moniz, T.; Rangel, M.; Realista, S.; Mourato, A.C.; Calhorda, M.J.. "Vanadyl cationic complexes as catalysts in olefin oxidation". Dalton Transactions 44 11 (2015): 5125-5138. http://www.scopus.com/inward/record.url?eid=2-s2.0-84924311136&partnerID=MN8TOARS.
  51. Moniz, T.; Silva, D.; Silva, T.; Gomes, M.S.; Rangel, M.. "Antimycobacterial activity of rhodamine 3,4-HPO iron chelators against Mycobacterium avium: Analysis of the contribution of functional groups and of chelator's combination with ethambutol". MedChemComm 6 12 (2015): 2194-2203. http://www.scopus.com/inward/record.url?eid=2-s2.0-84948746933&partnerID=MN8TOARS.
  52. Aguiar, A.; Leite, A.; Silva, A.M.N.; Tomé, A.C.; Cunha-Silva, L.; De Castro, B.; Rangel, M.; Silva, A.M.G.. "Isoxazolidine-fused meso-tetraarylchlorins as key tools for the synthesis of mono- and bis-annulated chlorins". Organic and Biomolecular Chemistry 13 26 (2015): 7131-7135. http://www.scopus.com/inward/record.url?eid=2-s2.0-84934967583&partnerID=MN8TOARS.
  53. Coelho, S.C.; Rangel, M.; Pereira, M.C.; Coelho, M.A.N.; Ivanova, G.. "Structural characterization of functionalized gold nanoparticles for drug delivery in cancer therapy: a NMR based approach". Physical Chemistry Chemical Physics 17 29 (2015): 18971-18979. http://www.scopus.com/inward/record.url?eid=2-s2.0-84937130815&partnerID=MN8TOARS.
  54. Queirõs, C.; Leite, A.; Couto, M.G.M.; Cunha-Silva, L.; Barone, G.; De Castro, B.; Rangel, M.; Silva, A.M.N.; Silva, A.M.G.. "The Influence of the Amide Linkage in the FeIII-Binding Properties of Catechol-Modified Rosamine Derivatives". Chemistry - A European Journal 21 44 (2015): 15692-15704. http://www.scopus.com/inward/record.url?eid=2-s2.0-84945480587&partnerID=MN8TOARS.
  55. Mesquita, R.B.R.; Moniz, T.; Miranda, J.L.A.; Gomes, V.; Silva, A.M.N.; Rodriguez-Borges, J.E.; Rangel, A.O.S.S.; Rangel, M.. "Synthesis and characterization of a 3-hydroxy-4-pyridinone chelator functionalized with a polyethylene glycol (PEG) chain aimed at sequential injection determination of iron in natural waters". Polyhedron 101 (2015): 171-178. http://www.scopus.com/inward/record.url?eid=2-s2.0-84942424474&partnerID=MN8TOARS.
  56. Coimbra, J.T.S.; Moniz, T.; Brás, N.F.; Ivanova, G.; Fernandes, P.A.; Ramos, M.J.; Rangel, M.. "Relevant interactions of antimicrobial iron chelators and membrane models revealed by nuclear magnetic resonance and molecular dynamics simulations". Journal of Physical Chemistry B 118 50 (2014): 14590-14601. http://www.scopus.com/inward/record.url?eid=2-s2.0-84919389836&partnerID=MN8TOARS.
  57. Fernandes, A.; Ivanova, G.; Brás, N.F.; Mateus, N.; Ramos, M.J.; Rangel, M.; De Freitas, V.. "Structural characterization of inclusion complexes between cyanidin-3-O-glucoside and ß-cyclodextrin". Carbohydrate Polymers 102 1 (2014): 269-277. http://www.scopus.com/inward/record.url?eid=2-s2.0-84890954600&partnerID=MN8TOARS.
  58. Queirós, C.; Leite, A.; Couto, M.G.M.; Moniz, T.; Cunha-Silva, L.; Gameiro, P.; Silva, A.M.G.; Rangel, M.. "Tuning the limits of pH interference of a rhodamine ion sensor by introducing catechol and 3-hydroxy-4-pyridinone chelating units". Dyes and Pigments 110 (2014): 193-202. http://www.scopus.com/inward/record.url?eid=2-s2.0-84905091164&partnerID=MN8TOARS.
  59. Silva, A.M.N.; Aguir, A.; Balula, S.S.; Silva, A.M.G.; Rangel, M.. "Characterization of a µ-oxo-bridged diiron porphyrin by ESI-LTQ-Orbitrap-MS". Journal of Mass Spectrometry 49 8 (2014): 763-765. http://www.scopus.com/inward/record.url?eid=2-s2.0-84904415852&partnerID=MN8TOARS.
  60. Rangel, M.; Leite, A.; Silva, A.M.N.; Moniz, T.; Nunes, A.; Amorim, M.J.; Queirós, C.; et al. "Distinctive EPR signals provide an understanding of the affinity of bis-(3-hydroxy-4-pyridinonato) copper(ii) complexes for hydrophobic environments". Dalton Transactions 43 25 (2014): 9722-9731. http://www.scopus.com/inward/record.url?eid=2-s2.0-84902106299&partnerID=MN8TOARS.
  61. Rangel, M.; Leite, A.; Silva, A.; De Castro, B.; Schlindwein, W.; Murphy, L.. "EPR and XANES studies of anaerobic photolysis of iso- propilpyridinecobaloxime: Elucidation of the reactivity of the Co(II) primary product". Journal of Organometallic Chemistry 760 (2014): 11-18. http://www.scopus.com/inward/record.url?eid=2-s2.0-84899450157&partnerID=MN8TOARS.
  62. Pinto, Jorge P.; Arezes, Joao; Dias, Vera; Oliveira, Susana; Viera, Ines; Costa, Monica; Vos, Matthijn; et al. "Physiological implications of NTBI uptake by T lymphocytes". Frontiers in Pharmacology 5 (2014): http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000347050100001&KeyUID=WOS:000347050100001.
  63. Coimbra, Joao T. S.; Sousa, Sergio F.; Fernandes, Pedro A.; Rangel, Maria; Ramos, Maria J.. "Biomembrane simulations of 12 lipid types using the general amber force field in a tensionless ensemble". Journal of Biomolecular Structure & Dynamics 32 1 (2014): 88-103. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000327236600008&KeyUID=WOS:000327236600008.
  64. Silva, Andre M. N.; Sousa, Paulo R. H.; Coimbra, Joao T. S.; Bras, Natercia F.; Vitorino, Rui; Fernandes, Pedro A.; Ramos, Maria J.; Rangel, Maria; Domingues, Pedro. "The glycation site specificity of human serum transferrin is a determinant for transferrin's functional impairment under elevated glycaemic conditions". Biochemical Journal 461 (2014): 33-42. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000337770800003&KeyUID=WOS:000337770800003.
  65. Passos, Marieta L. C.; Pereira, Mariana; Saraiva, M. Lucia M. F. S.; Rangel, Maria; Moniz, Tania; Santos, Joao L. M.; Frigerio, Christian. "Silica nanostructures synthesis and CdTe quantum dots immobilization for photocatalytical applications". Rsc Advances 4 104 (2014): 59697-59705. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000345654000002&KeyUID=WOS:000345654000002.
  66. Moniz, T.; Queirós, C.; Ferreira, R.; Leite, A.; Gameiro, P.; Silva, A.M.G.; Rangel, M.. "Design of a water soluble 1,8-naphthalimide/3-hydroxy-4-pyridinone conjugate: Investigation of its spectroscopic properties at variable pH and in the presence of Fe3+, Cu2+ and Zn2+". Dyes and Pigments 98 2 (2013): 201-211. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875334258&partnerID=MN8TOARS.
  67. Leite, A.; Silva, A.M.G.; Cunha-Silva, L.; De Castro, B.; Gameiro, P.; Rangel, M.. "Discrimination of fluorescence light-up effects induced by pH and metal ion chelation on a spirocyclic derivative of rhodamine B". Dalton Transactions 42 17 (2013): 6110-6118. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875802969&partnerID=MN8TOARS.
  68. Mesquita, R.B.R.; Suárez, R.; Cerdà, V.; Rangel, M.; Rangel, A.O.S.S.. "Exploiting the use of 3,4-HPO ligands as nontoxic reagents for the determination of iron in natural waters with a sequential injection approach". Talanta 108 (2013): 38-45. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875410468&partnerID=MN8TOARS.
  69. Simeonova, M.; Rangel, M.; Ivanova, G.. "NMR study of the supramolecular structure of dual drug-loaded poly(butylcyanoacrylate) nanoparticles". Physical Chemistry Chemical Physics 15 39 (2013): 16657-16664. http://www.scopus.com/inward/record.url?eid=2-s2.0-84884310217&partnerID=MN8TOARS.
  70. Moniz, T.; Nunes, A.; Silva, A.M.G.; Queirós, C.; Ivanova, G.; Gomes, M.S.; Rangel, M.. "Rhodamine labeling of 3-hydroxy-4-pyridinone iron chelators is an important contribution to target Mycobacterium avium infection". Journal of Inorganic Biochemistry 121 (2013): 156-166. http://www.scopus.com/inward/record.url?eid=2-s2.0-84873036807&partnerID=MN8TOARS.
  71. Arezes, Joao; Costa, Monica; Vieira, Ines; Dias, Vera; Kong, Xiao L.; Fernandes, Rui; Vos, Matthijn; et al. "Non-Transferrin-Bound Iron (NTBI) Uptake by T Lymphocytes: Evidence for the Selective Acquisition of Oligomeric Ferric Citrate Species". Plos One 8 11 (2013): http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000327539800027&KeyUID=WOS:000327539800027.
  72. Queirós, C.; Silva, A.M.G.; Lopes, S.C.; Ivanova, G.; Gameiro, P.; Rangel, M.. "A novel fluorescein-based dye containing a catechol chelating unit to sense iron(III)". Dyes and Pigments 93 1-3 (2012): 1447-1455. http://www.scopus.com/inward/record.url?eid=2-s2.0-80855147625&partnerID=MN8TOARS.
  73. Lopes, S.; Simeonova, M.; Gameiro, P.; Rangel, M.; Ivanova, G.. "Interaction of 5-fluorouracil loaded nanoparticles with 1,2-dimyristoyl- sn -glycero-3-phosphocholine liposomes used as a cellular membrane model". Journal of Physical Chemistry B 116 1 (2012): 667-675. http://www.scopus.com/inward/record.url?eid=2-s2.0-84855860358&partnerID=MN8TOARS.
  74. Cardoso, I.C.S.; Amorim, A.L.; Queirós, C.; Lopes, S.C.; Gameiro, P.; De Castro, B.; Rangel, M.; Silva, A.M.G.. "Microwave-assisted synthesis and spectroscopic properties of 4'-substituted rosamine fluorophores and naphthyl analogues". European Journal of Organic Chemistry 29 (2012): 5810-5817. http://www.scopus.com/inward/record.url?eid=2-s2.0-84866913763&partnerID=MN8TOARS.
  75. Leite, A.; Silva, A.M.G.; Nunes, A.; Andrade, M.; Sousa, C.; Cunha-Silva, L.; Gameiro, P.; De Castro, B.; Rangel, M.. "Novel tetradentate chelators derived from 3-hydroxy-4-pyridinone units: Synthesis, characterization and aqueous solution properties". Tetrahedron 67 22 (2011): 4009-4016. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955794728&partnerID=MN8TOARS.
  76. Silva, A.M.G.; Leite, A.; Gonzalez, P.; Domingues, M.R.M.; Gameiro, P.; De Castro, B.; Rangel, M.. "Use of a porphyrin platform and 3,4-HPO chelating units to synthesize ligands with N4 and O4 coordination sites". Tetrahedron 67 40 (2011): 7821-7828. http://www.scopus.com/inward/record.url?eid=2-s2.0-80052412453&partnerID=MN8TOARS.
  77. Biernacki, K.; Magalhães, A.L.; Freire, C.; Rangel, M.. "A DFT quantum mechanical study of 3-hydroxy-4-pyrone and 3-hydroxy-4-pyridinone based oxidovanadium(IV) complexes". Structural Chemistry 22 3 (2011): 697-706. http://www.scopus.com/inward/record.url?eid=2-s2.0-80051791689&partnerID=MN8TOARS.
  78. Moniz, T.; Amorim, M.J.; Ferreira, R.; Nunes, A.; Silva, A.; Queirós, C.; Leite, A.; et al. "Investigation of the insulin-like properties of zinc(II) complexes of 3-hydroxy-4-pyridinones: Identification of a compound with glucose lowering effect in STZ-induced type i diabetic animals". Journal of Inorganic Biochemistry 105 12 (2011): 1675-1682. http://www.scopus.com/inward/record.url?eid=2-s2.0-81055137648&partnerID=MN8TOARS.
  79. Queiros, C.; Amorim, M.J.; Leite, A.; Ferreira, M.; Gameiro, P.; De Castro, B.; Biernacki, K.; et al. "Nickel(II) and cobalt(II) 3-hydroxy-4-pyridinone complexes: Synthesis, characterization and speciation studies in aqueous solution". European Journal of Inorganic Chemistry 1 (2011): 131-140. http://www.scopus.com/inward/record.url?eid=2-s2.0-78650664335&partnerID=MN8TOARS.
  80. Ivanova, G.; Simeonova, M.; Cabrita, E.J.; Rangel, M.. "NMR insight into the supramolecular structure of daunorubicin loaded polymer nanoparticles". Journal of Physical Chemistry B 115 5 (2011): 902-909. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952826816&partnerID=MN8TOARS.
  81. Nunes, A.; Podinovskaia, M.; Leite, A.; Gameiro, P.; Zhou, T.; Ma, Y.; Kong, X.; et al. "Fluorescent 3-hydroxy-4-pyridinone hexadentate iron chelators: Intracellular distribution and the relevance to antimycobacterial properties". Journal of Biological Inorganic Chemistry 15 6 (2010): 861-877. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956481551&partnerID=MN8TOARS.
  82. Fernandes, S.S.; Nunes, A.; Gomes, A.R.; de Castro, B.; Hider, R.C.; Rangel, M.; Appelberg, R.; Gomes, M.S.. "Identification of a new hexadentate iron chelator capable of restricting the intramacrophagic growth of Mycobacterium avium". Microbes and Infection 12 4 (2010): 287-294. http://www.scopus.com/inward/record.url?eid=2-s2.0-77649274461&partnerID=MN8TOARS.
  83. Silva, A.M.G.; Leite, A.; Andrade, M.; Gameiro, P.; Brandão, P.; Felix, V.; De Castro, B.; Rangel, M.. "Microwave-assisted synthesis of 3-hydroxy-4-pyridinone/naphthalene conjugates. Structural characterization and selection of a fluorescent ion sensor". Tetrahedron 66 44 (2010): 8544-8550. http://www.scopus.com/inward/record.url?eid=2-s2.0-77957749950&partnerID=MN8TOARS.
  84. Peres, I.; Rocha, S.; Pereira, M.D.C.; Coelho, M.; Rangel, M.; Ivanova, G.. "NMR structural analysis of epigallocatechin gallate loaded polysaccharide nanoparticles". Carbohydrate Polymers 82 3 (2010): 861-866. http://www.scopus.com/inward/record.url?eid=2-s2.0-77955653668&partnerID=MN8TOARS.
  85. Pereira, C.; Leite, A.; Nunes, A.; Rebelo, S.L.H.; Rangel, M.; Freire, C.. "Oxidovanadium(IV) complexes of 3-hydroxy-4-pyrone and 3-hydroxy-4- pyridinone ligands: A new generation of homogeneous catalysts for the epoxidation of geraniol". Catalysis Letters 135 1-2 (2010): 98-104. http://www.scopus.com/inward/record.url?eid=2-s2.0-77649270360&partnerID=MN8TOARS.
  86. Oliveira, S.J.; Pinto, J.P.; Picarote, G.; Costa, V.M.; Carvalho, F.; Rangel, M.; de Sousa, M.; de Almeida, S.F.. "ER stress-inducible factor CHOP affects the expression of hepcidin by modulating C/EBPalpha activity". PLoS ONE 4 8 (2009): http://www.scopus.com/inward/record.url?eid=2-s2.0-68949162173&partnerID=MN8TOARS.
  87. Silva, A.M.G.; Castro, B.; Rangel, M.; Silva, A.M.S.; Brandão, P.; Felix, V.; Cavaleiro, J.A.S.. "Microwave-Enhanced Synthesis of Novel Pyridinone-Fused Porphyrins". Synlett 6 (2009): 1009-1013. http://www.scopus.com/inward/record.url?eid=2-s2.0-64349086012&partnerID=MN8TOARS.
  88. Rangel, M.; João Amorim, M.; Nunes, A.; Leite, A.; Pereira, E.; Castro, B.d.; Sousa, C.; Yoshikawa, Y.; Sakurai, H.. "Novel 3-hydroxy-4-pyridinonato oxidovanadium(IV) complexes to investigate structure/activity relationships". Journal of Inorganic Biochemistry 103 4 (2009): 496-502. http://www.scopus.com/inward/record.url?eid=2-s2.0-62349102322&partnerID=MN8TOARS.
  89. Gomes, J.; De Castro, B.; Rangel, M.. "EPR study of the photolysis of methyl- And adenosylcobinamides in the presence of phosphene and pyridine bases. Evidence for the need of a judicious choice of irradiation temperature and solvent to assess ligand binding". Organometallics 27 11 (2008): 2536-2543. http://www.scopus.com/inward/record.url?eid=2-s2.0-45449108465&partnerID=MN8TOARS.
  90. Burgess, J.; Parsons, S.A.; Singh, K.; Waltham, E.; López, P.; Sánchez, F.; Rangel, M.; Schlindwein, W.. "Ruthenium complexes of 3-hydroxy-4-pyranones and of 3-hydroxy-4-pyridinones". Transition Metal Chemistry 33 5 (2008): 553-561. http://www.scopus.com/inward/record.url?eid=2-s2.0-45849083849&partnerID=MN8TOARS.
  91. Neves, P.; Leite, A.; Rangel, M.; De Castro, B.; Gameiro, P.. "Influence of structural factors on the enhanced activity of moxifloxacin: A fluorescence and EPR spectroscopic study". Analytical and Bioanalytical Chemistry 387 4 (2007): 1543-1552. http://www.scopus.com/inward/record.url?eid=2-s2.0-33846863822&partnerID=MN8TOARS.
  92. Schlindwein, W.; Waltham, E.; Burgess, J.; Binsted, N.; Nunes, A.; Leite, A.; Rangel, M.. "New lipophilic 3-hydroxy-4-pyridinonate iron(III) complexes: Synthesis and EXAFS structural characterisation". Dalton Transactions 6 10 (2006): 1313-1321. http://www.scopus.com/inward/record.url?eid=2-s2.0-33644551227&partnerID=MN8TOARS.
  93. Rangel, M.; Leite, A.; Amorim, M.J.; Garribba, E.; Micera, G.; Lodyga-Chruscinska, E.. "Spectroscopic and potentiometric characterization of oxovanadium(IV) complexes formed by 3-hydroxy-4-pyridinones. Rationalization of the influence of basicity and electronic structure of the ligand on the properties of V IVO species in aqueous solution". Inorganic Chemistry 45 20 (2006): 8086-8097. http://www.scopus.com/inward/record.url?eid=2-s2.0-33750383413&partnerID=MN8TOARS.
  94. Rangel, M.; Leite, A.; Gomes, J.; De Castro, B.. "Photolysis secondary products of cobaloximes and imino/oxime compounds controlled by steric hindrance imposed by the Lewis base". Organometallics 24 14 (2005): 3500-3507. http://www.scopus.com/inward/record.url?eid=2-s2.0-22444437631&partnerID=MN8TOARS.
  95. Castro, M.M.C.A.; Avecilla, F.; Geraldes, C.F.G.C.; De Castro, B.; Rangel, M.. "Study of the oxidation products of the VO(dmpp)2 complex in aqueous solution under aerobic conditions: Comparison with the vanadate-dmpp system". Inorganica Chimica Acta 356 (2003): 142-154. http://www.scopus.com/inward/record.url?eid=2-s2.0-1042286391&partnerID=MN8TOARS.
  96. Rehder, D.; Pessoa, J.C.; Geraldes, C.F.G.C.; Castro, M.M.C.A.; Kabanos, T.; Kiss, T.; Meier, B.; et al. "Erratum: In vitro study of the insulin-mimetic behaviour of vanadium(IV, V) coordination compounds (Journal of Biological Inorganic Chemistry (2002) 7 (384-396))". Journal of Biological Inorganic Chemistry 7 6 (2002): http://www.scopus.com/inward/record.url?eid=2-s2.0-0036937457&partnerID=MN8TOARS.
  97. Rehder, D.; Costa Pessoa, J.; Geraldes, C.F.G.C.; Castro, M.M.C.A.; Kabanos, T.; Kiss, T.; Meier, B.; et al. "In vitro study of the insulin-mimetic behaviour of vanadium(IV, V) coordination compounds". Journal of Biological Inorganic Chemistry 7 4-5 (2002): 384-396. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036941223&partnerID=MN8TOARS.
  98. Rangel, M.; Pereira, E.; Oliveira, C.; De Castro, B.. "Characterization of the photolysis products of sec-butylcobaloximes with imidazole and benzimidazole bases". Journal of Organometallic Chemistry 632 1-2 (2001): 85-93. http://www.scopus.com/inward/record.url?eid=2-s2.0-0041869425&partnerID=MN8TOARS.
  99. Rangel, M.; Tamura, A.; Fukushima, C.; Sakurai, H.. "In vitro study of the insulin-like action of vanadyl-pyrone and -pyridinone complexes with a VO(O4) coordination mode". Journal of Biological Inorganic Chemistry 6 2 (2001): 128-132. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034839962&partnerID=MN8TOARS.
  100. Rangel, M.. "Pyridinone oxovanadium(IV) complexes: a new class of insulin mimetic compounds". Transition Metal Chemistry 26 1-2 (2001): 219-223. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035253235&partnerID=MN8TOARS.
  101. Castro, M.M.C.A.; Geraldes, C.F.G.C.; Gameiro, P.; Pereira, E.; Castro, B.; Rangel, M.. "Structural study of the interaction of vanadate with the ligand 1,2-dimethyl-3-hydroxy-4-pyridinone (Hdmpp) in aqueous solution". Journal of Inorganic Biochemistry 80 1-2 (2000): 177-179. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034732841&partnerID=MN8TOARS.
  102. Rangel, M.; Arcos, T.; De Castro, B.. "Photolysis Primary Products of Alkylcobaloximes Controlled by the Cobalt-Carbon Bond Strength". Organometallics 18 17 (1999): 3451-3456. http://www.scopus.com/inward/record.url?eid=2-s2.0-0001321794&partnerID=MN8TOARS.
  103. Schlindwein, W; Rangel, M; Burgess, J. "XAFS studies of pyranone and pyridinone metal(III) complexes". JOURNAL OF SYNCHROTRON RADIATION (1999):
  104. Rangel, M.; Pereira-Lima, L.; Waechter, F.L.. "The value of the left cholangiojejunostomy in the palliative treatment for malignant obstruction of the hepatic hilus,LA VALEUR DE LA CHOLANGIO-JEJUNOSTOMIE GAUCHE DANS LE TRAITEMENT PALLIATIF DE L'OBSTRUCTION MALIGNE DU HILE HEPATIQUE". Journal de Chirurgie 134 9-10 (1997): 401-405. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031408510&partnerID=MN8TOARS.
  105. Burgess, J.; De Castro, S.; Oliveira, C.; Rangel, M.; Schlindwein, W.. "Synthesis and characterization of 3-hydroxy-4-pyridinone-oxovanadium(IV) complexes". Polyhedron 16 5 (1996): 789-794. http://www.scopus.com/inward/record.url?eid=2-s2.0-0000686681&partnerID=MN8TOARS.
  106. Burgess, J.; De Castro, B.; Oliveira, C.; Rangel, M.. "Synthesis and Characterization of Some 1-Aryl-3-hydroxypyridin-4(1H)-ones. Solubilities and their Solvation in Methanol-Water Mixtures". Journal of Chemical Research - Part S 5 (1996): 234-235. http://www.scopus.com/inward/record.url?eid=2-s2.0-2742564168&partnerID=MN8TOARS.
  107. Arcos, T.; De Castro, B.; Ferreira, M.J.; Rangel, M.; Raynor, J.B.. "Electron spin resonance study of the cobalt(II) species formed after room-temperature photolysis of aqua(sec-butyl)bis(dimethylglyoximato)cobalt(III) in the presence of N-donor bases". Journal of the Chemical Society, Dalton Transactions 3 (1994): 369-377. http://www.scopus.com/inward/record.url?eid=2-s2.0-37049080028&partnerID=MN8TOARS.
  108. De Castro, B.; Pereira, J.; Rangel, M.. "EPR characterization of the photolysis and thermolysis products of alkylcobaloximes with symmetric phosphines and phosphites. Factors that stabilize the cobalt homolysis fragments". Organometallics 10 11 (1991): 3848-3855. http://www.scopus.com/inward/record.url?eid=2-s2.0-2542514123&partnerID=MN8TOARS.
  109. De Castro, B.; Rangel, M.; Raynor, J.B.. "An electron spin resonance spectral study of bis(dimethylglyoximato)-cobalt(II) and some phosphine and phosphite adducts". Journal of the Chemical Society, Dalton Transactions 11 (1990): 3311-3318. http://www.scopus.com/inward/record.url?eid=2-s2.0-37049081072&partnerID=MN8TOARS.
  110. Da Silva, M.A.V.R.; Da Silva, M.D.M.C.R.; Rangel, M.C.S.S.; Pilcher, G.; Akello, M.J.; Carson, A.S.; Jamea, E.H.. "Mean copper-ligand binding enthalpies in copper(II) complexes of dimethylglyoxime, glycine, acetic acid and 4-phenylamino-3-penten-2-one". Thermochimica Acta 160 2 (1990): 267-280. http://www.scopus.com/inward/record.url?eid=2-s2.0-4243224106&partnerID=MN8TOARS.
Capítulo de livro
  1. Burgess, John; Rangel, Maria. "Hydroxypyranones, hydroxypyridinones, and their complexes". In Advances in Inorganic Chemistry, 167-243. Elsevier, 2008.
Resumo em conferência
  1. Rangel, M; Vinhas, S; Ivanova, G; Lopes, S; Ferreira, S. "NMR Study of Partition and Permeation Properties of Ga(III) Chelates". 2019.
  2. Alves, EA; Soares, JX; Silva, AM; Neves, JF; Cravo, SM; Rangel, M; Afonso, CM; et al. "identification of a complex mixture of opioids on krokodil street-like samples". 2016.
  3. Ponte, F; Fraga, S; Moniz, T; da Silva, DD; Carvalho, F; Carmo, H; Remiao, F; Rangel, M; Bastos, ML. "Development of insulino-mimetic zinc(II) complexes of the class 3-hydroxy-4-pyridinone ligands: In vitro cytotoxicity studies for safety assessment". 2014.
  4. Rangel, M; Moniz, T; Leite, A; Gameiro, P. "Tagging 3-Hydroxy-4-Pyridinone Iron Chelators with Rhodamine B Derivatives is Essential to Target Mycobacterium Avium Infection". 2013.
  7. Rangel, M; Gameiro, P; Leite, A; Nunes, A; Zhou, T; Ma, YM; Hider, R. "Insight on the Diverse Cellular Pathways of Two Novel Chelators from Liposome Partition Studies". 2009.
  8. Rangel, M; Nunes, A; Leite, A; Gameiro, P; Castro, B. "Fluorescence studies on a novel iron(III) chelator with anti-microbial activity". 2007.
  9. Rangel, M; Pinto, R; Gameiro, P; Pereira, E; Castro, B; Burgess, J. "Study of the interaction of vanadyl ion with the ligand 1,2-dimethyl-3-hydroxy-4-pyridinone". 2001.


Título / Tema
Papel desempenhado
Curso (Tipo)
Instituição / Organização
2012/01/01 - 2016/05/04 Design of novel 3-hydroxy-4-pyridinone iron chelators to fight mycobacterium infection
Química Sustentável (Doutoramento)
Universidade do Porto Faculdade de Ciências, Portugal
2014 - 2015 Estudos em solução de complexos de vanádio com 3-hidroxi-4-piridinonas com potencial insulino-mimético
Bioengenharia (Mestrado)
Universidade do Porto Faculdade de Engenharia, Portugal
2006/01 - 2011/12 Design de ligandos quelantes multifuncionalizados derivados de 3,4-hidroxipiridinonas
Chemistry (Doutoramento)
Universidade do Porto Faculdade de Ciências, Portugal
2009/09 - 2010/10 Characterization of the anti-bacterial activity of the recently found iron chelator CP777 against Micobacterium avium
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2005 - 2009/09 Non-Transferrin Bound Iron: understanding the chemical nature of the species
2007 - 2007 Sistemas Miméticos de Biomembranas na Caracterização da Interacção, a Nível Molecular, de Quinolonas com a Proteína Membranar Ompf
Química (Doutoramento)
Universidade do Porto Faculdade de Ciências, Portugal
2003 - 2007 Síntese de Compostos Multi-funcionalizados Derivados de 3- Hidroxi-4-piridinonas com Potencial Aplicação Terapêutica e Como Sondas Intracelulares
Química (Doutoramento)
Universidade do Porto Faculdade de Ciências, Portugal
2003 - 2004 Synthesis and characterization of metal complexes with potential insulinmimetic behaviour
Chemistry (Mestrado)
Universidade do Porto Faculdade de Ciências, Portugal

Membro de associação

Nome da associação Tipo de participação
2015 - Atual Royal Society of Chemistry Member
2015 - Atual International Society for the Study of Iron in Biology and Medicine
2011 - Atual Sociedade Portuguesa de Química Member
2006 - Atual American Chemical Society Member
2006 - Atual Biophysical Society Member
2016 - 2018 Sociedade Portuguesa de Química-Presidente da Divisão de Química Inorgânica e Bioinorgânica