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Maria Rangel (MR) is Full Professor at Instituto de Ciências Biomédicas de Abel Salazar of University of Porto. She has been responsible for courses on Chemical Biology, Thermodynamics, Biophysical Chemistry and Structural Analysis. MR supervised the work of several Post-Doctoral, Ph.D., M.Sc. and Project Students. MR is a Bioinorganic Chemist whose domains of specialization are Inorganic and Physical Chemistry. MR has large experience in Coordination Chemistry and Spectroscopy. Since her Ph. D. MR has worked in the area of coordination chemistry and has acquired expertise in synthesis and characterization of transition metal complexes. She has developed a strong theoretical and experimental expertise on EPR Spectroscopy and X-ray Absorption Spectroscopy and a very good experience on other spectroscopic methods like NMR, Electronic Absorption and Fluorescence Spectroscopy, FTIR and MS which have been used mostly as characterization tools. MR research interests are focused in the role of metal ions in living organisms and, in the recent years she has worked on the design of Iron chelators for: (a) novel strategies to fight Infection through Fe deprivation; (b) treatment of Fe Overload and (c) Fe Sensing. Her interest in Iron Biology has been extended to Plant Nutrition. MR is currently developing projects that aim the understanding of mineral nutrition processes and design of Fe-chelates to address agricultural problems related with Fe deficiency. The development of insulin-like vanadium and zinc complexes and B12 model compounds are two topics that have also been explored in previous years. Maria Rangel has been Principal Investigator of several multidisciplinary projects and has a considerable experience in coordinating teams developing research on the interfaces of chemistry and biology. At present she is Head of Chemistry Department (ICBAS), Co-Director of the Integrated Master Course of Bioengineering; Co-Director of the Master Course of Bioengineering; Co-Director of the BSc Course of Bioengineering; Member of the Board of REQUIMTE and Scientist in charge of the NMR and EPR Laboratories of UPORTO.
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Identification

Personal identification

Full name
Maria Rangel

Citation names

  • Rangel, Maria

Author identifiers

Ciência ID
2E18-5B36-29C0
ORCID iD
0000-0002-0998-1437
AuthenticusID
R-000-ARW
Researcher Id
B-3732-2012
Scopus Author Id
55963098900

Email addresses

  • mrangel@icbas.up.pt (Professional)
  • mcrangel@fc.up.pt (Professional)

Telephones

Telephone
  • 220428337 (Professional)

Addresses

  • Instituto Ciências Biomédicas Abel Salazar, Universidade do Porto. Rua Jorge Viterbo Ferreira, 228, 4050-313, PORTO, Porto, Portugal (Professional)

Websites

Knowledge fields

  • Exact Sciences - Chemical Sciences - Inorganic Chemistry
  • Agrarian Sciences
  • Natural sciences - Biological Sciences - Biophysics

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
French Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Education
Degree Classification
2011
Concluded
 Agregação em Ciências Biomédicas (Título de Agregado)
Major in Ciências Biomédicas
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
""n/a"" (THESIS/DISSERTATION)
 Aprovado por unanimidade
1989
Concluded
 Doutoramento em Ciências Biomédicas (Doutoramento)
Major in Ciências Biomédicas (Química)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
"Aplicação da Espectroscopia de Ressonância de Spin Electrónico ao Estudos dos Produtos de Fotólise de Compostos Modelo da VItamina B12" (THESIS/DISSERTATION)
 Aprovado com distinção e louvor
1978
Concluded
 Licenciatura em Química-Ramo Científico-Especialidade de Química Física e Inorgânica (Licenciatura)
Universidade do Porto Faculdade de Ciências, Portugal
""n/a"" (THESIS/DISSERTATION)
 16 valores
1976/07
Concluded
 Bacharelato em Química (Bacharelato)
Universidade do Porto, Portugal
Affiliation

Teaching in Higher Education

Category
Host institution 		Employer
1992/02/23 - Current Associate Professor (University Teacher) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
1989/10/03 - 1992/02/22 Assistant Professor (University Teacher) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
1980/10/01 - 1989/10/01 Assistant (University Teacher) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
1978/10/01 - 1980/09/30 Trainee Assistant (University Teacher) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
1978/04/01 - 1978/09/01 Tutor (University Teacher) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Positions / Appointments

Category
Host institution 		Employer
2022/02/14 - Current Head of Chemistry Department Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2021 - Current Co-Diretor da Licenciatura em Bioengenharia Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2021 - Current Co-Diretor do Mestrado em Bioengenharia Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2015/09/28 - Current Co-Diretor do Mestrado Integrado em Bioengenharia Universidade do Porto, Portugal
2015/09/28 - Current Membro da Comissão Científica do Mestrado Integrado em Bioengenharia Universidade do Porto, Portugal
2015/09/28 - Current Membro da Comissão de Acompanhamento do Mestrado Integrado em Bioengenharia Universidade do Porto, Portugal
2002 - Current Membro da Comissão Científica e Técnica do REQUIMTE REQUIMTE LAQV Porto, Portugal
REQUIMTE LAQV Porto, Portugal
2013 - 2014 Conselho científico/técnico-científico ou orgão correspondente Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
Projects

Contract

Designation Funders
2023/01/02 - 2024/07/01 eQuaNTI: An enzymatic assay for the determination of blood serum non-transferrin-bound iron.
2022.06328.PTDC
10.54499/2022.06328.PTDC
Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Centro Hospitalar Universitário de Santo António, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2016/06 - 2019/11 (Fe)rrying plants to prevent chlorosis
PTDC/AGRPRO/3515/2014
 Fundação para a Ciência e a Tecnologia

Other

Designation Funders
2022/01/01 - 2023/06/01 Cellulose-based iron nanofertilizers for sustainable growth of soybean plants.
EXPL/QUI-QIN/0411/2021
Researcher
REQUIMTE LAQV Porto, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2019/11/01 - 2022/10/31 Fluorecent chelators for metal ion sensing in water.
PTDC/QUI-QIN/28142/2017
Researcher
Universidade Católica Portuguesa, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2018/07/01 - 2021/06/30 Polyphenols in Art: chemistry and biology hand in hand with conservation of cultural heritage
PTDC/QUI-OUT/29925/2017
Researcher
Associação para a Inovação e Desenvolvimento da FCT, Portugal

Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2018/06/01 - 2021/05/31 Xanthene-based optical sensors
PTDC/QUI-QOR/29426/2017
Researcher
Universidade de Aveiro, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2013/07/01 - 2015/12/31 EnvIRONsensing - Novel iron sensing systems for biogeochemical applications
PTDC/AAG-MAA/3978/2012
Researcher
Universidade Católica Portuguesa, Portugal

Universidade do Porto Instituto de Ciências e Tecnologias Agrárias e Agro-Alimentares, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2011/04/01 - 2014/09/30 Protection from iron toxicity by the immune system: cells, proteins and mechanisms
PTDC/SAU-MET/113011/2009
Researcher
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Universidade do Porto Instituto de Ciências e Tecnologias Agrárias e Agro-Alimentares, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2009/01/02 - 2012/06/30 Novel Key Molecular Architectures to Target Infection
PTDC/QUI/67915/2006
Principal investigator
Universidade do Porto Instituto de Ciências e Tecnologias Agrárias e Agro-Alimentares, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2005/01/01 - 2008/06/30 Design of macromolecular intracellular iron chelators and evaluation of their anti-microbial activity
POCI/QUI/56214/2004
Principal investigator
REQUIMTE LAQV Porto, Portugal

Universidade do Porto Instituto de Ciências e Tecnologias Agrárias e Agro-Alimentares, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2005/10/01 - 2007/06/30 Design of new Vanadium compounds: towards their application as anti-diabetic and anti-cancer agents
POCI/QUI/56949/2004
Researcher
Universidade de Lisboa Instituto Superior Técnico, Portugal

Universidade de Lisboa Centro de Química Estrutural, Portugal

Universidade do Porto Instituto de Ciências e Tecnologias Agrárias e Agro-Alimentares, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2002 - 2004 Estudo de Factores Estruturais Determinantes na Reactividade dos Produtos de Fotólise de Compostos Modelo do Sistema B12
POCTI/QUI/46231/2002
Principal investigator
Universidade do Porto Faculdade de Ciências, Portugal
Concluded
Outputs

Publications

Book chapter
  1. Burgess, John; Rangel, Maria. "Hydroxypyranones, hydroxypyridinones, and their complexes". In Advances in Inorganic Chemistry, 167-243. Elsevier, 2008.
    10.1016/s0898-8838(08)00005-6
Conference abstract
  1. Rangel, M; Vinhas, S; Ivanova, G; Lopes, S; Ferreira, S. "NMR Study of Partition and Permeation Properties of Ga(III) Chelates". 2019.
    10.1016/j.bpj.2018.11.2753
  2. Alves, EA; Soares, JX; Silva, AM; Neves, JF; Cravo, SM; Rangel, M; Afonso, CM; et al. "identification of a complex mixture of opioids on krokodil street-like samples". 2016.
    10.1016/j.toxlet.2016.06.2039
  3. Ponte, F; Fraga, S; Moniz, T; da Silva, DD; Carvalho, F; Carmo, H; Remiao, F; Rangel, M; Bastos, ML. "Development of insulino-mimetic zinc(II) complexes of the class 3-hydroxy-4-pyridinone ligands: In vitro cytotoxicity studies for safety assessment". 2014.
    10.1016/j.toxlet.2014.06.226
  4. Rangel, M; Moniz, T; Leite, A; Gameiro, P. "Tagging 3-Hydroxy-4-Pyridinone Iron Chelators with Rhodamine B Derivatives is Essential to Target Mycobacterium Avium Infection". 2013.
  5. Moniz, T; Gomes, MS; Rangel, M. "RHODAMINE LABELING OF 3-HYDROXY-4-PYRIDINONE IRON CHELATORS IS AN IMPORTANT CONTRIBUTION TO TARGET MYCOBACTERIUM AVIUM INFECTION". 2013.
  6. Rangel, M; Moniz, T; Leite, A; Gameiro, P; Ivanova, G. "FLUORESCENT IRON CHELATORS WITH ANTIMICROBIAL ACTIVITY: INSIGHT ON STRUCTURE-ACTIVITY RELATIONSHIPS FROM LIPOSOME PARTITION STUDIES". 2013.
  7. Rangel, M; Gameiro, P; Leite, A; Nunes, A; Zhou, T; Ma, YM; Hider, R. "Insight on the Diverse Cellular Pathways of Two Novel Chelators from Liposome Partition Studies". 2009.
  8. Rangel, M; Nunes, A; Leite, A; Gameiro, P; Castro, B. "Fluorescence studies on a novel iron(III) chelator with anti-microbial activity". 2007.
  9. Rangel, M; Pinto, R; Gameiro, P; Pereira, E; Castro, B; Burgess, J. "Study of the interaction of vanadyl ion with the ligand 1,2-dimethyl-3-hydroxy-4-pyridinone". 2001.
Journal article
  1. Silvia Vinhas; Mafalda Sarraguça; Tânia Moniz; Salette Reis; Maria Rangel. "A New Microwave-Assisted Protocol for Cellulose Extraction from Eucalyptus and Pine Tree Wood Waste". Polymers (2023): https://www.mdpi.com/2073-4360/16/1/20.
    10.3390/polym16010020
  2. Luísa M. P. F. Amaral; Tânia Moniz; Silva A. M. N.; Maria Rangel. "Vanadium Compounds with Antidiabetic Potential". International Journal of Molecular Sciences (2023): https://www.mdpi.com/1422-0067/24/21/15675.
    10.3390/ijms242115675
  3. Juliana I. S. Aguiar; Susana O. Ribeiro; Andreia Leite; Maria Rangel; António O. S. S. Rangel; Raquel Mesquita. "Iron Determination in Natural Waters Using a Synthesised 3-Hydroxy-4-Pyridione Ligand in a Newly Developed Microfluidic Paper-Based Device". Chemosensors (2023): https://www.mdpi.com/2227-9040/11/2/101.
    10.3390/chemosensors11020101
  4. Oliveira, IM; Gomes, IB; Moniz, T; Simoes, LC; Rangel, M; Simoes, M. "Realism-based assessment of the efficacy of potassium peroxymonosulphate on Stenotrophomonas maltophilia biofilm control". JOURNAL OF HAZARDOUS MATERIALS (2023):
    10.1016/j.jhazmat.2023.132348
  5. Vinhas, S; Ivanova, G; de Castro, B; Rangel, M. "NMR and EPR study of the interaction of tris(3-hydroxy-4-pyridinonato) Ga (III) complexes with liposomes that mimic plant membranes". BIOPHYSICAL CHEMISTRY (2023):
    10.1016/j.bpc.2023.107021
  6. Almeida, J; Tome, AC; Rangel, M; Silva, AMG. "Microwave-Assisted Synthesis and Spectral Properties of Pyrrolidine-Fused Chlorin Derivatives". MOLECULES (2023):
    10.3390/molecules28093833
  7. Miranda, JLA; Mesquita, RBR; Leite, A; Silva, AMN; Rangel, M; Rangel, AOSS. "Non-transferrin-bound iron determination in blood serum using microsequential injection solid phase spectrometry- proof of concept". TALANTA (2023):
    10.1016/j.talanta.2023.124345
  8. Lopes, JC; Moniz, T; Sampaio, MJ; Silvia, CG; Rangel, M; Faria, JL. "Efficient synthesis of imines using carbon nitride as photocatalyst". CATALYSIS TODAY (2023):
    10.1016/j.cattod.2023.114045
  9. Carla Queirós; Sílvia Vinhas; Jéssica Oliveira; Andreia Leite; Ana M. G. Silva; Maria Rangel. "Functionalization of Rhodamine Platforms with 3-Hydroxy-4-pyridinone Chelating Units and Its Fluorescence Behavior towards Fe(III)". Molecules (2022): https://www.mdpi.com/1420-3049/27/5/1567.
    10.3390/molecules27051567
  10. Moreira, MIF; Almeida, J; Leite, A; Ferreira, AIMCL; Santos, LMNBF; Silva, AMG; Rangel, M. "Ohmic heating-assisted synthesis and characterization of Zn(ii), Cu(ii) and Pd(ii) complexes of heterocyclic-fused chlorins". DALTON TRANSACTIONS (2022):
    10.1039/d1dt04032d
  11. Mesquita, Raquel B. R.; Moniz, Tânia; Nunes, Maria J. M.; Mesquita, Letícia S.; Rangel, Maria; Rangel, António O. S. S.. "Sequential injection method for bi-parametric determination of iron and manganese in soil leachates". Analytical Methods 14 2 (2022): 180-187. http://dx.doi.org/10.1039/d1ay01932e.
    Published • 10.1039/d1ay01932e
  12. Amaral, LMPF; Moniz, T; Leite, A; Oliveira, A; Fernandes, P; Ramos, MJ; Araujo, AN; et al. "A combined experimental and computational study to discover novel tyrosinase inhibitors". JOURNAL OF INORGANIC BIOCHEMISTRY (2022):
    10.1016/j.jinorgbio.2022.111879
  13. Aníbal Silva; Carla Queirós; Andreia Leite; María T. Rodríguez; María J. Rojo; Tomás Torroba; Rui C. Martins; Ana M. G. Silva; Maria Rangel. "Synthesis of Catechol Derived Rosamine Dyes and Their Reactivity toward Biogenic Amines". Molecules (2021): https://www.mdpi.com/1420-3049/26/16/5082.
    10.3390/molecules26165082
  14. Santos, C.S.; Rodrigues, E.; Ferreira, S.; Moniz, T.; Leite, A.; Carvalho, S.M.P.; Vasconcelos, M.W.; Rangel, M.. "Foliar application of 3-hydroxy-4-pyridinone Fe-chelate [Fe(mpp)3] induces responses at the root level amending iron deficiency chlorosis in soybean". Physiologia Plantarum 173 1 (2021): 235-245. http://www.scopus.com/inward/record.url?eid=2-s2.0-85102427959&partnerID=MN8TOARS.
    10.1111/ppl.13367
  15. Silva, A.M.N.; Moniz, T.; de Castro, B.; Rangel, M.. "Human transferrin: An inorganic biochemistry perspective". Coordination Chemistry Reviews 449 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85114843974&partnerID=MN8TOARS.
    10.1016/j.ccr.2021.214186
  16. Loureiro, DRP; Soares, JX; Maia, A; Silva, AMN; Rangel, M; Azevedo, CMG; Hansen, SV; et al. "One-Pot Synthesis of Xanthone by Carbonylative Suzuki Coupling Reaction". CHEMISTRYSELECT (2021):
    10.1002/slct.202101394
  17. Vargas, A.P.; Almeida, J.; Gámez, F.; Roales, J.; Queirós, C.; Rangel, M.; Lopes-Costa, T.; Silva, A.M.G.; Pedrosa, J.M.. "Synthesis of a highly emissive carboxylated pyrrolidine-fused chlorin for optical sensing of TATP vapours". Dyes and Pigments 195 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85112767542&partnerID=MN8TOARS.
    10.1016/j.dyepig.2021.109721
  18. Almeida, J; Zhang, GY; Wang, MD; Queiros, C; Cerqueira, AFR; Tome, AC; Barone, G; et al. "Synthesis, characterization, and cellular investigations of porphyrin-and chlorin-indomethacin conjugates for photodynamic therapy of cancer". ORGANIC & BIOMOLECULAR CHEMISTRY (2021):
    10.1039/d1ob01015h
  19. Ribas, Tânia C.F.; Mesquita, Raquel B.R.; Moniz, Tânia; Rangel, Maria; Rangel, António O.S.S.. "Greener and wide applicability range flow-based spectrophotometric method for iron determination in fresh and marine water". Talanta 216 (2020): 120925. http://dx.doi.org/10.1016/j.talanta.2020.120925.
    10.1016/j.talanta.2020.120925
  20. Moniz, Tânia; Bassett, Chelsea R.; Almeida, M. Inês G.S.; Kolev, Spas D.; Rangel, Maria; Mesquita, Raquel B.R.. "Use of an ether-derived 3-hydroxy-4-pyridinone chelator as a new chromogenic reagent in the development of a microfluidic paper-based analytical device for Fe(III) determination in natural waters". Talanta 214 (2020): 120887. http://dx.doi.org/10.1016/j.talanta.2020.120887.
    10.1016/j.talanta.2020.120887
  21. Mesquita, Letícia S.; Mesquita, Raquel B. R.; Leite, Andreia; Moniz, Tânia; Rangel, Maria; Rangel, António O. S. S.. "Integrated Flow-based System Displaying an In-line Mini Soil Column to Monitor Iron Species in Soils Leachates". Communications in Soil Science and Plant Analysis (2020): 1-12. http://dx.doi.org/10.1080/00103624.2020.1751186.
    10.1080/00103624.2020.1751186
  22. Nabais, P.; Oliveira, J.; Pina, F.; Teixeira, N.; de Freitas, V.; Brás, N. F.; Clemente, A.; et al. "A 1000-year-old mystery solved: Unlocking the molecular structure for the medieval blue from Chrozophora tinctoria, also known as folium". Science Advances 6 16 (2020): eaaz7772. http://dx.doi.org/10.1126/sciadv.aaz7772.
    10.1126/sciadv.aaz7772
  23. Santos, CS; Leite, A; Vinhas, S; Ferreira, S; Moniz, T; Vasconcelos, MW; Rangel, M. "A combined physiological and biophysical approach to understand the ligand-dependent efficiency of 3-hydroxy-4-pyridinone Fe-chelates". PLANT DIRECT (2020):
    10.1002/pld3.256
  24. Moniz, T; Cunha Silva, L; Mesquita, RBR; Miranda, JLA; Silva, AMN; Silva, AMG; Rangel, AOSS; de Castro, B; Rangel, M. "New hydrophilic 3-hydroxy-4-pyridinone chelators with ether-derived substituents: Synthesis and evaluation of analytical performance in the determination of iron in waters". POLYHEDRON (2019):
    10.1016/j.poly.2018.12.005
  25. Miranda, JLA; Mesquita, RBR; Nunes, A; Rangel, M; Rangel, AOSS. "Determination of iron(III) in water samples by microsequential injection solid phase spectrometry using an hexadentate 3-hydroxy-4-pyridinone chelator as reagent". TALANTA (2019):
    10.1016/j.talanta.2018.08.063
  26. Leite, A; Cunha Silva, L; Silva, D; Ferreira, AIMCL; Santos, LMNBF; Cardoso, ICS; Silva, VLM; Rangel, M; Silva, AMG. "Synthesis of Pyridyl and N-Methylpyridinium Analogues of Rosamines: Relevance of Solvent and Charge on Their Photophysical Properties". CHEMISTRY-A EUROPEAN JOURNAL (2019):
    10.1002/chem.201903313
  27. Leite, A; Bessa, LJ; Silva, AMG; Gameiro, P; de Castro, B; Rangel, M. "Antibacterial activity of naphthyl derived bis-(3-hydroxy-4-pyridinonate) copper(II) complexes against multidrug-resistant bacteria". JOURNAL OF INORGANIC BIOCHEMISTRY (2019):
    10.1016/j.jinorgbio.2019.110704
  28. Rebelo, SLH; Moniz, T; Medforth, CJ; de Castro, B; Rangel, M. "EPR spin trapping studies of H2O2 activation in metaloporphyrin catalyzed oxygenation reactions: Insights on the biomimetic mechanism". MOLECULAR CATALYSIS (2019):
    10.1016/j.mcat.2019.110500
  29. Coimbra, JTS; Bras, NF; Fernandes, PA; Rangel, M; Ramos, MJ. "A computational study on the redox properties and binding affinities of iron complexes of hydroxypyridinones". JOURNAL OF MOLECULAR MODELING (2019):
    10.1007/s00894-019-4037-0
  30. Almeida, J; Fortuna, ME; Pricop, L; Lobiuc, A; Leite, A; Silva, AMN; Monteiro, RP; et al. "(Aminophenyl)porphyrins as precursors for the synthesis of porphyrin-modified siloxanes". JOURNAL OF PORPHYRINS AND PHTHALOCYANINES (2019):
    10.1142/s1088424619500573
  31. Maria Rangel; Tânia Moniz; Silva A. M. N.; Andreia Leite. "Tuning the Anti(myco)bacterial Activity of 3-Hydroxy-4-pyridinone Chelators through Fluorophores". Pharmaceuticals (2018): http://www.mdpi.com/1424-8247/11/4/110.
    10.3390/ph11040110
  32. Silva, AMN; Coimbra, JTS; Castro, MM; Oliveira, A; Bras, NF; Fernandes, PA; Ramos, MJ; Rangel, M. "Determining the glycation site specificity of human holo-transferrin". JOURNAL OF INORGANIC BIOCHEMISTRY (2018):
    10.1016/j.jinorgbio.2018.05.016
  33. Coimbra, JTS; Bras, NF; Fernandes, PA; Rangel, M; Ramos, MJ. "Membrane partition of bis-(3-hydroxy-4pyridinonato) zinc(ii) complexes revealed by molecular dynamics simulations". RSC ADVANCES (2018):
    10.1039/c8ra03602k
  34. Almeida, J; Silva, AMN; Rebelo, SLH; Cunha Silva, L; Rangel, M; de Castro, B; Leite, A; Silva, AMG. "Synthesis and coordination studies of 5-(4 '-carboxyphenyl)-10,15,20-tris(pentafluorophenyl) porphyrin and its pyrrolidine-fused chlorin derivative". NEW JOURNAL OF CHEMISTRY (2018):
    10.1039/c7nj05165d
  35. Ferreira, S; Leite, A; Moniz, T; Andrade, M; Amaral, L; de Castro, B; Rangel, M. "EPR and V-51 NMR studies of prospective anti-diabetic bis(3-hydroxy-4-pyridinonato) oxidovanadium(IV) complexes in aqueous solution and liposome suspensions". NEW JOURNAL OF CHEMISTRY (2018):
    10.1039/c7nj04678b
  36. Novais, A; Moniz, T; Rebelo, AR; Silva, AMG; Rangel, M; Peixe, L. "New fluorescent rosamine chelator showing promising antibacterial activity against Gram-positive bacteria". BIOORGANIC CHEMISTRY (2018):
    10.1016/j.bioorg.2018.05.013
  37. Moniz, T; Feio, M; Silva, D; de Castro, B; Rangel, M. "Study of the effect of thiourea and N-ethyl groups on antibacterial activity of rhodamine-labeled 3,4-HPO iron chelators against Gram ( plus /-) bacteria". MEDICINAL CHEMISTRY RESEARCH (2018):
    10.1007/s00044-018-2165-1
  38. Queirós, C.; Leite, A.; Cunha-Silva, L.; de Castro, B.; Rangel, M.; Sousaraei, A.; Cabanillas-Gonzalez, J.; et al. "Synthesis and characterization of two fluorescent isophthalate rosamines: From solution to immobilization in solid substrates". Dyes and Pigments 157 (2018): 405-414. http://www.scopus.com/inward/record.url?eid=2-s2.0-85047511709&partnerID=MN8TOARS.
    10.1016/j.dyepig.2018.05.005
  39. Moniz, T.; Dias Da Silva, D.; Carmo, H.; De Castro, B.; De Lourdes Bastos, M.; Rangel, M.. "Insights on the relationship between structure vs. toxicological activity of antibacterial rhodamine-labelled 3-hydroxy-4-pyridinone iron(III) chelators in HepG2 cells". Interdisciplinary Toxicology 11 3 (2018): 189-199. http://www.scopus.com/inward/record.url?eid=2-s2.0-85074514686&partnerID=MN8TOARS.
    10.2478/intox-2018-0016
  40. da Conceição Rangel, Maria; Vasconcelos, Marta. "(Fe)rrying plants to prevent chlorosis". Impact 2017 11 (2017): 79-81. http://dx.doi.org/10.21820/23987073.2017.11.79.
    10.21820/23987073.2017.11.79
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  91. Fernandes, S.S.; Nunes, A.; Gomes, A.R.; de Castro, B.; Hider, R.C.; Rangel, M.; Appelberg, R.; Gomes, M.S.. "Identification of a new hexadentate iron chelator capable of restricting the intramacrophagic growth of Mycobacterium avium". Microbes and Infection 12 4 (2010): 287-294. http://www.scopus.com/inward/record.url?eid=2-s2.0-77649274461&partnerID=MN8TOARS.
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  92. Silva, A.M.G.; Leite, A.; Andrade, M.; Gameiro, P.; Brandão, P.; Felix, V.; De Castro, B.; Rangel, M.. "Microwave-assisted synthesis of 3-hydroxy-4-pyridinone/naphthalene conjugates. Structural characterization and selection of a fluorescent ion sensor". Tetrahedron 66 44 (2010): 8544-8550. http://www.scopus.com/inward/record.url?eid=2-s2.0-77957749950&partnerID=MN8TOARS.
    10.1016/j.tet.2010.08.065
  93. Peres, I.; Rocha, S.; Pereira, M.D.C.; Coelho, M.; Rangel, M.; Ivanova, G.. "NMR structural analysis of epigallocatechin gallate loaded polysaccharide nanoparticles". Carbohydrate Polymers 82 3 (2010): 861-866. http://www.scopus.com/inward/record.url?eid=2-s2.0-77955653668&partnerID=MN8TOARS.
    10.1016/j.carbpol.2010.06.007
  94. Pereira, C.; Leite, A.; Nunes, A.; Rebelo, S.L.H.; Rangel, M.; Freire, C.. "Oxidovanadium(IV) complexes of 3-hydroxy-4-pyrone and 3-hydroxy-4- pyridinone ligands: A new generation of homogeneous catalysts for the epoxidation of geraniol". Catalysis Letters 135 1-2 (2010): 98-104. http://www.scopus.com/inward/record.url?eid=2-s2.0-77649270360&partnerID=MN8TOARS.
    10.1007/s10562-010-0281-8
  95. Oliveira, S.J.; Pinto, J.P.; Picarote, G.; Costa, V.M.; Carvalho, F.; Rangel, M.; de Sousa, M.; de Almeida, S.F.. "ER stress-inducible factor CHOP affects the expression of hepcidin by modulating C/EBPalpha activity". PLoS ONE 4 8 (2009): http://www.scopus.com/inward/record.url?eid=2-s2.0-68949162173&partnerID=MN8TOARS.
    10.1371/journal.pone.0006618
  96. Silva, A.M.G.; Castro, B.; Rangel, M.; Silva, A.M.S.; Brandão, P.; Felix, V.; Cavaleiro, J.A.S.. "Microwave-Enhanced Synthesis of Novel Pyridinone-Fused Porphyrins". Synlett 6 (2009): 1009-1013. http://www.scopus.com/inward/record.url?eid=2-s2.0-64349086012&partnerID=MN8TOARS.
    10.1055/s-0028-1088205
  97. Rangel, M.; João Amorim, M.; Nunes, A.; Leite, A.; Pereira, E.; Castro, B.d.; Sousa, C.; Yoshikawa, Y.; Sakurai, H.. "Novel 3-hydroxy-4-pyridinonato oxidovanadium(IV) complexes to investigate structure/activity relationships". Journal of Inorganic Biochemistry 103 4 (2009): 496-502. http://www.scopus.com/inward/record.url?eid=2-s2.0-62349102322&partnerID=MN8TOARS.
    10.1016/j.jinorgbio.2008.12.019
  98. Gomes, J.; De Castro, B.; Rangel, M.. "EPR study of the photolysis of methyl- And adenosylcobinamides in the presence of phosphene and pyridine bases. Evidence for the need of a judicious choice of irradiation temperature and solvent to assess ligand binding". Organometallics 27 11 (2008): 2536-2543. http://www.scopus.com/inward/record.url?eid=2-s2.0-45449108465&partnerID=MN8TOARS.
    10.1021/om700837d
  99. Burgess, J.; Parsons, S.A.; Singh, K.; Waltham, E.; López, P.; Sánchez, F.; Rangel, M.; Schlindwein, W.. "Ruthenium complexes of 3-hydroxy-4-pyranones and of 3-hydroxy-4-pyridinones". Transition Metal Chemistry 33 5 (2008): 553-561. http://www.scopus.com/inward/record.url?eid=2-s2.0-45849083849&partnerID=MN8TOARS.
    10.1007/s11243-008-9079-6
  100. Neves, P.; Leite, A.; Rangel, M.; De Castro, B.; Gameiro, P.. "Influence of structural factors on the enhanced activity of moxifloxacin: A fluorescence and EPR spectroscopic study". Analytical and Bioanalytical Chemistry 387 4 (2007): 1543-1552. http://www.scopus.com/inward/record.url?eid=2-s2.0-33846863822&partnerID=MN8TOARS.
    10.1007/s00216-006-1009-x
  101. Schlindwein, W.; Waltham, E.; Burgess, J.; Binsted, N.; Nunes, A.; Leite, A.; Rangel, M.. "New lipophilic 3-hydroxy-4-pyridinonate iron(III) complexes: Synthesis and EXAFS structural characterisation". Dalton Transactions 6 10 (2006): 1313-1321. http://www.scopus.com/inward/record.url?eid=2-s2.0-33644551227&partnerID=MN8TOARS.
    10.1039/b509671e
  102. Rangel, M.; Leite, A.; Amorim, M.J.; Garribba, E.; Micera, G.; Lodyga-Chruscinska, E.. "Spectroscopic and potentiometric characterization of oxovanadium(IV) complexes formed by 3-hydroxy-4-pyridinones. Rationalization of the influence of basicity and electronic structure of the ligand on the properties of V IVO species in aqueous solution". Inorganic Chemistry 45 20 (2006): 8086-8097. http://www.scopus.com/inward/record.url?eid=2-s2.0-33750383413&partnerID=MN8TOARS.
    10.1021/ic0605571
  103. Rangel, M.; Leite, A.; Gomes, J.; De Castro, B.. "Photolysis secondary products of cobaloximes and imino/oxime compounds controlled by steric hindrance imposed by the Lewis base". Organometallics 24 14 (2005): 3500-3507. http://www.scopus.com/inward/record.url?eid=2-s2.0-22444437631&partnerID=MN8TOARS.
    10.1021/om0580046
  104. Castro, M.M.C.A.; Avecilla, F.; Geraldes, C.F.G.C.; De Castro, B.; Rangel, M.. "Study of the oxidation products of the VO(dmpp)2 complex in aqueous solution under aerobic conditions: Comparison with the vanadate-dmpp system". Inorganica Chimica Acta 356 (2003): 142-154. http://www.scopus.com/inward/record.url?eid=2-s2.0-1042286391&partnerID=MN8TOARS.
    10.1016/S0020-1693(03)00473-0
  105. Rehder, D.; Pessoa, J.C.; Geraldes, C.F.G.C.; Castro, M.M.C.A.; Kabanos, T.; Kiss, T.; Meier, B.; et al. "Erratum: In vitro study of the insulin-mimetic behaviour of vanadium(IV, V) coordination compounds (Journal of Biological Inorganic Chemistry (2002) 7 (384-396))". Journal of Biological Inorganic Chemistry 7 6 (2002): http://www.scopus.com/inward/record.url?eid=2-s2.0-0036937457&partnerID=MN8TOARS.
    10.1007/s00775-002-0372-0
  106. Rehder, D.; Costa Pessoa, J.; Geraldes, C.F.G.C.; Castro, M.M.C.A.; Kabanos, T.; Kiss, T.; Meier, B.; et al. "In vitro study of the insulin-mimetic behaviour of vanadium(IV, V) coordination compounds". Journal of Biological Inorganic Chemistry 7 4-5 (2002): 384-396. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036941223&partnerID=MN8TOARS.
    10.1007/s00775-001-0311-5
  107. Rangel, M.; Pereira, E.; Oliveira, C.; De Castro, B.. "Characterization of the photolysis products of sec-butylcobaloximes with imidazole and benzimidazole bases". Journal of Organometallic Chemistry 632 1-2 (2001): 85-93. http://www.scopus.com/inward/record.url?eid=2-s2.0-0041869425&partnerID=MN8TOARS.
    10.1016/S0022-328X(01)00854-3
  108. Rangel, M.; Tamura, A.; Fukushima, C.; Sakurai, H.. "In vitro study of the insulin-like action of vanadyl-pyrone and -pyridinone complexes with a VO(O4) coordination mode". Journal of Biological Inorganic Chemistry 6 2 (2001): 128-132. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034839962&partnerID=MN8TOARS.
    10.1007/s007750000180
  109. Rangel, M.. "Pyridinone oxovanadium(IV) complexes: a new class of insulin mimetic compounds". Transition Metal Chemistry 26 1-2 (2001): 219-223. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035253235&partnerID=MN8TOARS.
    10.1023/A:1007130400129
  110. Castro, M.M.C.A.; Geraldes, C.F.G.C.; Gameiro, P.; Pereira, E.; Castro, B.; Rangel, M.. "Structural study of the interaction of vanadate with the ligand 1,2-dimethyl-3-hydroxy-4-pyridinone (Hdmpp) in aqueous solution". Journal of Inorganic Biochemistry 80 1-2 (2000): 177-179. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034732841&partnerID=MN8TOARS.
    10.1016/s0162-0134(00)00028-3
  111. Rangel, M.; Arcos, T.; De Castro, B.. "Photolysis Primary Products of Alkylcobaloximes Controlled by the Cobalt-Carbon Bond Strength". Organometallics 18 17 (1999): 3451-3456. http://www.scopus.com/inward/record.url?eid=2-s2.0-0001321794&partnerID=MN8TOARS.
    10.1021/om990078s
  112. Schlindwein, W; Rangel, M; Burgess, J. "XAFS studies of pyranone and pyridinone metal(III) complexes". JOURNAL OF SYNCHROTRON RADIATION (1999):
    10.1107/s0909049598016525
  113. Rangel, M.; Pereira-Lima, L.; Waechter, F.L.. "The value of the left cholangiojejunostomy in the palliative treatment for malignant obstruction of the hepatic hilus,LA VALEUR DE LA CHOLANGIO-JEJUNOSTOMIE GAUCHE DANS LE TRAITEMENT PALLIATIF DE L'OBSTRUCTION MALIGNE DU HILE HEPATIQUE". Journal de Chirurgie 134 9-10 (1997): 401-405. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031408510&partnerID=MN8TOARS.
  114. Burgess, J.; De Castro, S.; Oliveira, C.; Rangel, M.; Schlindwein, W.. "Synthesis and characterization of 3-hydroxy-4-pyridinone-oxovanadium(IV) complexes". Polyhedron 16 5 (1996): 789-794. http://www.scopus.com/inward/record.url?eid=2-s2.0-0000686681&partnerID=MN8TOARS.
    10.1016/s0277-5387(96)00343-9
  115. Burgess, J.; De Castro, B.; Oliveira, C.; Rangel, M.. "Synthesis and Characterization of Some 1-Aryl-3-hydroxypyridin-4(1H)-ones. Solubilities and their Solvation in Methanol-Water Mixtures". Journal of Chemical Research - Part S 5 (1996): 234-235. http://www.scopus.com/inward/record.url?eid=2-s2.0-2742564168&partnerID=MN8TOARS.
  116. Arcos, T.; De Castro, B.; Ferreira, M.J.; Rangel, M.; Raynor, J.B.. "Electron spin resonance study of the cobalt(II) species formed after room-temperature photolysis of aqua(sec-butyl)bis(dimethylglyoximato)cobalt(III) in the presence of N-donor bases". Journal of the Chemical Society, Dalton Transactions 3 (1994): 369-377. http://www.scopus.com/inward/record.url?eid=2-s2.0-37049080028&partnerID=MN8TOARS.
    10.1039/DT9940000369
  117. De Castro, B.; Pereira, J.; Rangel, M.. "EPR characterization of the photolysis and thermolysis products of alkylcobaloximes with symmetric phosphines and phosphites. Factors that stabilize the cobalt homolysis fragments". Organometallics 10 11 (1991): 3848-3855. http://www.scopus.com/inward/record.url?eid=2-s2.0-2542514123&partnerID=MN8TOARS.
    10.1021/om00057a014
  118. De Castro, B.; Rangel, M.; Raynor, J.B.. "An electron spin resonance spectral study of bis(dimethylglyoximato)-cobalt(II) and some phosphine and phosphite adducts". Journal of the Chemical Society, Dalton Transactions 11 (1990): 3311-3318. http://www.scopus.com/inward/record.url?eid=2-s2.0-37049081072&partnerID=MN8TOARS.
    10.1039/DT9900003311
  119. Da Silva, M.A.V.R.; Da Silva, M.D.M.C.R.; Rangel, M.C.S.S.; Pilcher, G.; Akello, M.J.; Carson, A.S.; Jamea, E.H.. "Mean copper-ligand binding enthalpies in copper(II) complexes of dimethylglyoxime, glycine, acetic acid and 4-phenylamino-3-penten-2-one". Thermochimica Acta 160 2 (1990): 267-280. http://www.scopus.com/inward/record.url?eid=2-s2.0-4243224106&partnerID=MN8TOARS.
    10.1016/0040-6031(90)80266-2

Other

Other output
  1. The (Bio)Chemistry of Non-Transferrin-Bound Iron. 2022. Silva, AMN; Rangel, M.
    10.3390/molecules27061784
Activities

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2012/01/01 - 2016/05/04 Design of novel 3-hydroxy-4-pyridinone iron chelators to fight mycobacterium infection
Supervisor
 Química Sustentável (PhD)
Universidade do Porto Faculdade de Ciências, Portugal
2014 - 2015 Estudos em solução de complexos de vanádio com 3-hidroxi-4-piridinonas com potencial insulino-mimético
Supervisor
 Bioengenharia (Master)
Universidade do Porto Faculdade de Engenharia, Portugal
2006/01 - 2011/12 Design de ligandos quelantes multifuncionalizados derivados de 3,4-hidroxipiridinonas
Supervisor
 Chemistry (PhD)
Universidade do Porto Faculdade de Ciências, Portugal
2009/09 - 2010/10 Characterization of the anti-bacterial activity of the recently found iron chelator CP777 against Micobacterium avium
Co-supervisor
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2005 - 2009/09 Non-Transferrin Bound Iron: understanding the chemical nature of the species
Co-supervisor
2007 - 2007 Sistemas Miméticos de Biomembranas na Caracterização da Interacção, a Nível Molecular, de Quinolonas com a Proteína Membranar Ompf
Co-supervisor
 Química (PhD)
Universidade do Porto Faculdade de Ciências, Portugal
2003 - 2007 Síntese de Compostos Multi-funcionalizados Derivados de 3- Hidroxi-4-piridinonas com Potencial Aplicação Terapêutica e Como Sondas Intracelulares
Supervisor
 Química (PhD)
Universidade do Porto Faculdade de Ciências, Portugal
2003 - 2004 Synthesis and characterization of metal complexes with potential insulinmimetic behaviour
Supervisor
 Chemistry (Master)
Universidade do Porto Faculdade de Ciências, Portugal

Association member

Society Organization name Role
2015 - Current Royal Society of Chemistry Member
2015 - Current International Society for the Study of Iron in Biology and Medicine
2011 - Current Sociedade Portuguesa de Química Member
2006 - Current American Chemical Society Member
2006 - Current Biophysical Society Member
2016 - 2018 Sociedade Portuguesa de Química-Presidente da Divisão de Química Inorgânica e Bioinorgânica