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Andreia Alexandra Santos de Areosa Pena obtained her bachelor's degree in Biochemistry in 2013 and her master's degree in 2015 from the Faculdade de Ciências, Universidade de Lisboa. Since 2018, she has been pursuing her PhD at the Vascular Morphogenesis Lab under the supervision of Dr. Claudio A. Franco at the Instituto de Medicina Molecular-João Lobo Antunes. Her PhD thesis focuses on the "Molecular Mechanisms Controlling Physiological and Pathological Angiogenesis." Currently, Andreia is working at the Vascular Biology and Disease Lab at Católica Biomedical Research, Universidade Católica. Her scientific interests revolve around vascular development (angiogenesis) and vascular diseases, particularly the pathological dysfunction of blood vessels. She is particularly interested in studying the behavior of endothelial and mural cells within the vascular tree, as they play a crucial role in ensuring proper blood distribution and supply to all tissues in multicellular organisms. The vascular network is essential for embryonic development, growth, and wound healing. Importantly, many human disorders, such as diabetic retinopathy, arteriovenous malformations, and ischemia, arise from abnormalities in blood vessel patterning.
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Identificação

Identificação pessoal

Nome completo
Andreia Alexandra Santos de Areosa Pena

Nomes de citação

  • Pena, Andreia

Identificadores de autor

Ciência ID
2B1A-DE71-B60B
ORCID iD
0000-0003-1668-0891

Endereços de correio eletrónico

  • andreia.pena@medicina.ulisboa.pt (Profissional)
  • apena@ucp.pt (Profissional)

Moradas

  • IMM . Faculdade de Medicina da Universidade de Lisboa Av. Professor Egas Moniz, 1649-028 L, Lisboa, Lisboa, Portugal (Profissional)
  • R Quinta Grande 6, IGC, 2780-156, Oeiras, Lisboa, Portugal (Profissional)

Websites

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Inglês Utilizador independente (B1) Utilizador independente (B1) Utilizador independente (B1) Utilizador independente (B1)
Francês Utilizador elementar (A1) Utilizador independente (B1) Utilizador elementar (A2) Utilizador elementar (A2)
Formação
Grau Classificação
2018/01 - 2024/12/31
Em curso
 Biomedicina (Doutoramento)
Instituto de Medicina Molecular João Lobo Antunes, Portugal

Universidade de Lisboa Faculdade de Medicina, Portugal
"Molecular mechanisms controlling physiological and pathological angiogenesis" (TESE/DISSERTAÇÃO)
2015
Concluído
 Bioquímica (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
"An innovative strategy for therapeutic angiogenesis: Low doses of Ionizing Radiation" (TESE/DISSERTAÇÃO)
 17
2013
Concluído
 Bioquímica (Licenciatura)
Universidade de Lisboa Faculdade de Ciências, Portugal
"n/a" (TESE/DISSERTAÇÃO)
 14
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2024/01/01 - 2025/12/31 Investigador Contratado (Investigação) Universidade Católica Portuguesa, Portugal
Católica Biomedical Research Centre, Portugal
2018/01/01 - 2023/12/31 Investigador (Investigação) Instituto de Medicina Molecular João Lobo Antunes, Portugal
2015/12/01 - 2016/09/01 Investigador (Investigação) Universidade de Lisboa Centro Cardiovascular da Universidade de Lisboa, Portugal
2014/09/01 - 2015/11/19 Estagiário de Investigação (Investigação) Universidade de Lisboa Centro Cardiovascular da Universidade de Lisboa, Portugal
2013/01/01 - 2014/09/01 Estagiário de Investigação (Investigação) Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
Projetos

Projeto

Designação Financiadores
2024/01/01 - 2025/12/31 ECARD: Endothelial Cells as rheostats for Age-Related diseases
HR22-00551
Investigador
Em curso
2022/04/01 - 2023/12/30 Estudo da dinâmica do pericito durante o desenvolvimento vascular
EXPL/MED-ANM/1616/2021
Bolseiro de Doutoramento
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2018/01 - 2021 Flow(in)DR
PTDC/MED-PAT/31639/2017
Bolseiro de Doutoramento
Concluído

Outro

Designação Financiadores
2014/09 - 2015/11 Low doses of Ionizing Radiation Induce Angiogenesis: Therapeutic Implications
info:eu-repo/grantAgreement/NIH/NATIONAL CANCER INSTITUTE/5R01CA033821-03/US
Outra
National Institutes of Health
2013/09 - 2014/09 The extracellular matrix modulates H2O2 degradation and redox signalling in endothelial cells
na
Outra
Produções

Publicações

Artigo em conferência
  1. Markus Koerbel; Alessandro Ciccarelli; Christopher J Peddie; Andreia Pena; Daniela Ramalho; Irene Aspalter; Claudio A Fr. "Multi-scale imaging and automated analysis of neovascular tufts". Trabalho apresentado em 2024 ARVO Annual Meeting, 2024.
Artigo em jornal
  1. Yi Jin; Yindi Ding; Mark Richards; Mika Kaakinen; Wolfgang Giese; Elisabeth Baumann; Anna Szymborska; et al. "Tyrosine-protein kinase Yes controls endothelial junctional plasticity and barrier integrity by regulating VE-cadherin phosphorylation and endocytosis", Nature Cardiovascular Research, 2022, http://dx.doi.org/10.1038/s44161-022-00172-z.
    10.1038/s44161-022-00172-z
  2. Pedro Barbacena; Maria Dominguez-Cejudo; Catarina G. Fonseca; Manuel Gómez-González; Laura M. Faure; Georgia Zarkada; Andreia Pena; et al. "Competition for endothelial cell polarity drives vascular morphogenesis in the mouse retina", Developmental Cell, 2022, http://dx.doi.org/10.1016/j.devcel.2022.09.002.
    10.1016/j.devcel.2022.09.002
  3. Marie Ouarné; Andreia Pena; Cláudio Areias Franco. "From remodeling to quiescence: The transformation of the vascular network", Cells & Development, 2021, http://dx.doi.org/10.1016/j.cdev.2021.203735.
    10.1016/j.cdev.2021.203735
  4. Ana Figueiredo; Pedro Barbacena; Ana Russo; Silvia Vaccaro; Daniela Ramalho; Andreia Pena; Aida Pires Lima; et al. "Endothelial cell invasion is controlled by dactylopodia", Proceedings of the National Academy of Sciences, 2021, http://dx.doi.org/10.1073/pnas.2023829118.
    10.1073/pnas.2023829118
  5. Pena, Andreia; Marie Ouarné; Cláudio Areias Franco. "Methods to quantify endothelial cell front-rear polarity in vivo and in vitro", Curr Opin Hematol ., 2021
    10.1097/MOH.0000000000000643
  6. Prahst, Claudia; Ashrafzadeh, Parham; Mead, Thomas; Figueiredo, Ana; Chang, Karen; Richardson, Douglas; Venkaraman, Lakshmi; et al. "Mouse retinal cell behaviour in space and time using light sheet fluorescence microscopy", eLife, 2020, http://dx.doi.org/10.7554/elife.49779.
    10.7554/elife.49779
  7. Bagulho, Ana; Vilas-Boas, Filipe; Pena, Andreia; Peneda, Catarina; Santos, Filipa C.; Jerónimo, Ana; de Almeida, Rodrigo F.M.; Real, Carla. "The extracellular matrix modulates H2O2 degradation and redox signaling in endothelial cells", Redox Biology, 2015, http://dx.doi.org/10.1016/j.redox.2015.09.006.
    10.1016/j.redox.2015.09.006
Artigo em revista
  1. Marie Ouarné; Andreia Pena; Daniela Ramalho; Nadine V. Conchinha; Tiago Costa; Romain Enjalbert; Ana M. Figueiredo; et al. "A non-genetic model of vascular shunts informs on the cellular mechanisms of formation and resolution of arteriovenous malformations". Cardiovascular Research 120 15 (2024): 1967-1984. https://ciencia.ucp.pt/en/publications/40369004-c22d-4690-b66d-ad54c403db6b.
    10.1093/cvr/cvae160
  2. Catarina Sequeira; Lou Martha Wackerbarth; Andreia Pena; Mafalda Sá-Pereira; Franco CA; Edgar R. Gomes. "Myonuclear position and blood vessel organization during skeletal muscle postnatal development". Development (Cambridge) 151 19 (2024): https://ciencia.ucp.pt/en/publications/92e8262e-b48d-4502-9356-966ba1ef67ca.
    10.1242/dev.202548
  3. Holly Elizabeth Lovegrove; Sabrina Ghadaouia ; Georgia E Hulmes ; Christopher Keith Revell; Marta Giralt-Pujol; Zain Alhashem; Andreia Pena; et al. "Cell shape dynamics trigger transitions in cell state via geometric tuning of mitotic symmetry". Science (2024):
    Em revisão
Poster em conferência
  1. Pena, Andreia. "“NM-myosin-IIA is essential in pathological and physiological angiogenesis”". Trabalho apresentado em Endothelial Cell Phenotypes in Health and Disease, GRC, 2024.
  2. Ouarné, Marie; Ramalho, Daniela; Pena, Andreia. Autor correspondente: Ramalho, Daniela. "A non-genetic model of vascular shunts informs on the cellular mechanisms of formation and resolution of arteriovenous malformations". Trabalho apresentado em Endothelial Cell Phenotypes in Health and Disease, GRC, 2024.
  3. Pena, Andreia. "A Non-genetic model of vascular shunts informs on the cellular mechanisms of formation and resolution of Arteriovenous Malformations". Trabalho apresentado em Rede Saúde, ULisboa, 2024.
  4. Ramalho, Daniela; Pena, Andreia; Nadine Conchinha; Lenka Henao Misikova; Rui Benedito; Cláudio Franco. "Migration-based mechanisms of arteriogenesis". Trabalho apresentado em Leducq Attract meeting, 2023.
  5. Pena, Andreia; Daniela Ramalho; Marie Ouarné; Nadine Conchinha; Lenka Henao Misikova; Yulia Carvalho; Ana Figueiredo; Cláudio Franco. "NM-MYOSIN-IIA IS ESSENTIAL FOR PERICYTE MIGRATION AND VASCULAR STABILITY DURING SPROUTING ANGIOGENESIS". Trabalho apresentado em Leducq Attract meeting, 2023.
  6. Pena, Andreia. "NM-Myosin-IIA is essential for PC migration and vascular stability during sprouting angiogenesis". Trabalho apresentado em Symposium in Vascular Biomedicine, Berlin, 2023.
  7. Ramalho, Daniela; Pena, Andreia; Nadine Conchinha; Lenka Misiková; Rui Benedito; Cláudio Franco. "Migration-based mechanisms of arteriogenesis". Trabalho apresentado em Leducq Attract meeting, 2022.
  8. Pena, Andreia; Pezzarossa, Anna; Franco, Cláudio. "Deregulated Endothelial Blood Flow Response as a cause of Diabetic Retinopathy". Trabalho apresentado em Leducq Attract meeting, 2022.
  9. Daniela ramalh; Pena, Andreia; Nadine Conchinha; Lenka Henao Misíková; Rui Benedito; Cláudio Franco. "Migration-based mechanisms of arteriogenesis". Trabalho apresentado em XV CAML · V NeurULisboa PhD Students, 2022.
  10. Pena, Andreia; Pezzarossa, Anna; Franco, Claudio A. "Deregulated Endothelial Blood Flow Response as a cause of Diabetic Retinopathy". Trabalho apresentado em xiii caml phd meeting, Lisbon, Portugal, 2019.
  11. Pena, Andreia; Pezzarossa, Anna; Franco, Claudio A. "Deregulated Endothelial Blood Flow Response as a cause of Diabetic Retinopathy". Trabalho apresentado em Symposia on Tumour Biology, Lisbon, Portugal, 2018.
  12. Bagulho, Ana; Vilas-Boas, Filipe; Pena, Andreia; Peneda, Catarina; Santos, Filipa C.; Jerónimo, Ana; de Almeida, Rodrigo F.M.; Real, Carla. "The extracellular matrix modulates H2O2 degradation and redox signalling in endothelial cells". Trabalho apresentado em CQB Day, Faculty of Sciences, University of Lisbon, 2015.
Tese / Dissertação
  1. "Molecular mechanisms controlling physiological and pathological angiogenesis". Doutoramento, Universidade de Lisboa, 2023. aguarda defesa do doutoramento.
  2. Pena, Andreia. "An innovative strategy for therapeutic angiogenesis: Low doses of Ionizing Radiation". Mestrado, Universidade de Lisboa, 2015. http://hdl.handle.net/10451/22295.
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2025/02/15 A non-genetic model of vascular shunts informs on the cellular mechanisms of formation and resolution of arteriovenous malformations XV Congresso Novas Fronteiras em Medicina Cardiovascular - 8ª Edição Prémio AIDFM-CETERA
2024 A Non-genetic model of vascular shunts informs on the cellular mechanisms of formation and resolution of Arteriovenous Malformations Rede Saúde
ULisboa
2024 NM-myosin-IIA is essential in pathological and physiological angiogenesis” CBR _PhD day
2023/07 "NM-Myosin-IIA is essential for PC migration and vascular stability during sprouting angiogenesis" Leducq Attract meeting
(Berlim, Alemanha)
2022/11 “NM-MIIA is essential for pericyte migration and proliferation”, Católica Biomedical Research Center, 1st CBR Get-together
Universidade Catolica Portuguesa, CBR (Católica Biomedical Research Center)
2022/06 “NM-MIIA is essential for pericyte migration and proliferation” Leducq Attract meeting
(Edimburgh, Reino Unido)
2022/05 "Unveiling the effects of Myh9 in pericytes during sprouting angiogenesis" XV CAML · V NeurULisboa PhD Students
instituto de medicina molecular
2021/05 "Unveiling the effects of Myh9 in pericytes during sprouting angiogenesis" 3rd International Course on Cell Biology & Cancer
Institute Curie
2021/05 "Unveiling the effects of Myh9 in pericytes during sprouting angiogenesis" XIV CAML · IV NeurULisboa PhD Students (Virtual Meeting)
instituto de medicina molecular
2018/05/25 "Evaluating the contribution of endothelial-flow response in Diabetic Retinopathy" XII CAML PhD Meeting
(Portugal)

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação) 		Instituição / Organização
2020 - 2021 Organizer of the Pizza seminars for PhD students (2020 - 2021)
Seminário (Coorganizador)
 Instituto de Medicina Molecular João Lobo Antunes, Portugal

Participação em evento

Descrição da atividade
Tipo de evento 		Nome do evento
Instituição / Organização
2023 - Atual Job shadowing CBR where we showeddifferent students our work and thetype of research we are doing in the lab.
Outro
 Job shadowing CBR
Universidade Católica Portuguesa Campus Sintra, Portugal
2025/02/24 - 2025/02/25 Formação em Comunicação de Ciência: Comunicação oral em ciência – apresentações para audiências, narrativas e linguagem não verbal Escrita de ciência para públicos leigos – princípios de jornalismo de ciência Comunicação visual em ciência – slides e posters, outros suportes visuais
Oficina (workshop)
 Formação em Comunicação de Ciência
Universidade de Lisboa, Portugal
2025/02/14 - 2025/02/16 XV Congresso Novas Fronteiras em Medicina Cardiovascular - Este Congresso visa, em primeiro lugar, promover a discussão aberta sobre novas fronteiras no que tem sido uma evolução fascinante no âmbito do diagnóstico e terapêutica cardiovascular. Nele participam um vasto número de peritos nacionais e estrangeiros, constituindo uma excelente oportunidade de formação pós-graduada na área da Medicina Cardiovascular.
Congresso
 XV Congresso Novas Fronteiras em Medicina Cardiovascular
2024/09 - 2024/09 Noite Europeia dos Investigadores - NEI Oeiras 2024 Este evento visou desmistificar a investigação e aproximar a ciência do público. Noite Europeia dos Investigadores
2024/04 - 2024/04 Webinar: Managing Genetically Engineered Animals Through the Lens of the 4Rs
Oficina (workshop)
 Managing Genetically Engineered Animals Through the Lens of the 4Rs
2024 - 2024 The FELASA (Federation of European Laboratory Animal Science Associations) Workshop on Severity Classification of Procedures is an event focused on discussing and establishing guidelines for categorizing the severity of experimental procedures involving laboratory animals. FELASA plays a crucial role in promoting the ethical use of animals in research and education across Europe. The severity classification of procedures is an essential aspect of animal research ethics, as it helps researchers, institutional animal care committees, and regulatory FELASA Workshop on Severity Classification of Procedures
2023/07/13 - 2023/07/13 Symposium: Vascular Biomedicine Berlin - From Cellular Networks to Systems Medicine of Vascular Malformations
Simpósio
2023 - 2023 Introduction to 3D image analysis in Imaris - This course provided hands-on training in 3D image analysis via the Imaris software. It covered everything from how to get images converted to .ims format, to using the generated surfaces to analyze 3D and 4D data, including showing the new features the recently released Imaris 10 provides. This course is aimed at bioscience researchers and technicians from all levels with an interest in analyzing their 3D/4D datasets. Introduction to 3D image analysis in Imaris
2019 - 2023 Leducq ATTRACT meeting Leducq meeting
2022/01 - 2022/01 webinar on optimising animal dosing studies (Injection or Infusion? Insights for Your Next Animal Dosing Investigation)
Oficina (workshop)
 Injection or Infusion? Insights for Your Next Animal Dosing Investigation
2022 - 2022 Nature masterclass - On-demand online courses Self-paced learning in convenient bite-sized units, with videos and engaging learning activities. Popular courses: Writing a Research Paper: 2nd Edition Publishing a Research Paper Persuasive Grant Writing Nature masterclass, (virtual)
2021 - 2021 3rd International Course on Cell Biology & Cancer (virtual)
Institut Curie, França
2020 - 2021 COVID-19 Diagnostic Task Force - Sample processing I Patient Diagnosis,
Outro
Instituto de Medicina Molecular João Lobo Antunes, Portugal
2020 - 2021 Science Careers Workshop Series
Oficina (workshop)
Instituto de Medicina Molecular João Lobo Antunes, Portugal
2019 - 2019 Workshop "Turn Yourself Into a Successful Speaker"
Oficina (workshop)
 Workshop "Turn Yourself Into a Successful Speaker"
Instituto de Medicina Molecular João Lobo Antunes, Portugal
2019 - 2019 Workshop "How to represent your data"
Oficina (workshop)
 Workshop "How to represent your data"
2019 - 2019 DevBioMed Symposium
Simpósio
 DevBioMed Symposium
Fundação Champalimaud, Portugal
2018 - 2018 Workshop "Graphical design: How to tell a story with a picture”
Oficina (workshop)
 Workshop "Graphical design: How to tell a story with a picture”
Instituto de Medicina Molecular João Lobo Antunes, Portugal
2018 - 2018 Module VI - Statistical Tests | Introduction to Clinical Research: a pratical course Module VI - Statistical Tests | Introduction to Clinical Research: a pratical course
Instituto de Medicina Molecular João Lobo Antunes, Portugal
2018 - 2018 Workshop Key Differences Among B6 Substrains: “Know Your B6 Mouse and the Research Impact” and “Strategies to Minimize Genetic Drift and Maximize Experimental Reproducibility in Mouse Research” (Charles River)
Oficina (workshop)
 Workshop Key Differences Among B6 Substrains: “Know Your B6 Mouse and the Research Impact” and “Strategies to Minimize Genetic Drift and Maximize Experimental Reproducibility in Mouse Research” (Charles River)
Instituto de Medicina Molecular João Lobo Antunes, Portugal
2018 - 2018 ReTuBi Workshop on High-Resolution Light Microscopy – 2nd Edition
Oficina (workshop)
 ReTuBi Workshop on High-Resolution Light Microscopy – 2nd Edition
Instituto de Medicina Molecular João Lobo Antunes, Portugal
2018 - 2018 Symposium on tumour biology: From basic biology to disease Symposium on tumour biology: From basic biology to disease
2018 - 2018 Biophysical Constraints and Evolutionary Cell Biology Workshop
Oficina (workshop)
 Biophysical Constraints and Evolutionary Cell Biology Workshop
Instituto Gulbenkian de Ciência, Portugal
2018 - 2018 Cell migration under confinement Workshop
Oficina (workshop)
 Cell migration under confinement Workshop
2018 - 2018 LinkedIn Workshop
Oficina (workshop)
 LinkedIn Workshop
Instituto de Medicina Molecular João Lobo Antunes, Portugal
2016 - 2016 Laboratory Animal Science (FELASA Cat. B)
Outro
 Laboratory Animal Science (FELASA Cat. B)
Instituto de Medicina Molecular João Lobo Antunes, Portugal
2016 - 2016 Course in Histopathology in biomedical research: Show me your mouse and will show you your phenotype
Oficina (workshop)
 Course in Histopathology in biomedical research: Show me your mouse and will show you your phenotype
Instituto de Medicina Molecular João Lobo Antunes, Portugal
2015 - 2015 Synposium Thymus Synposium Thymus
Instituto de Medicina Molecular João Lobo Antunes, Portugal
2015 - 2015 Bioimaging course in microscopy Bioimaging course in microscopy
Instituto de Medicina Molecular João Lobo Antunes, Portugal
2015 - 2015 Course in Angiogenesis Course in Angiogenesis
Instituto de Medicina Molecular João Lobo Antunes, Portugal
Distinções

Prémio

2025 PRÉMIO AIDFM - CETERA - Cardiovascular Research 2024 –3º lugar - Melhor Artigo Científico: A non-genetic model of vascular shunts informs on the cellular mechanisms of formation and resolution of arteriovenous malformations
2024 Best poster award “NM-myosin-IIA is essential in pathological and physiological angiogenesis”, Endothelial Cell Phenotypes in Health and Disease, GRC
2022 XV CAML · V NeurULisboa PhD Students Meeting | Award Experts Category - oral presentation

Outra distinção

2017 PhD Fellowship from FCT (SFRH/BD/130635/2017 and COVID/BD/152399/2022)
Fundação para a Ciência e a Tecnologia, Portugal