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Andreia Alexandra Santos de Areosa Pena obtained her bachelor's degree in Biochemistry in 2013 and her master's degree in 2015 from the Faculdade de Ciências, Universidade de Lisboa. Since 2018, she has been pursuing her PhD at the Vascular Morphogenesis Lab under the supervision of Dr. Claudio A. Franco at the Instituto de Medicina Molecular-João Lobo Antunes. Her PhD thesis focuses on the "Molecular Mechanisms Controlling Physiological and Pathological Angiogenesis." Currently, Andreia is working at the Vascular Biology and Disease Lab at Católica Biomedical Research, Universidade Católica. Her scientific interests revolve around vascular development (angiogenesis) and vascular diseases, particularly the pathological dysfunction of blood vessels. She is particularly interested in studying the behavior of endothelial and mural cells within the vascular tree, as they play a crucial role in ensuring proper blood distribution and supply to all tissues in multicellular organisms. The vascular network is essential for embryonic development, growth, and wound healing. Importantly, many human disorders, such as diabetic retinopathy, arteriovenous malformations, and ischemia, arise from abnormalities in blood vessel patterning.
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Identification

Personal identification

Full name
Andreia Alexandra Santos de Areosa Pena

Citation names

  • Pena, Andreia

Author identifiers

Ciência ID
2B1A-DE71-B60B
ORCID iD
0000-0003-1668-0891

Email addresses

  • andreia.pena@medicina.ulisboa.pt (Professional)
  • apena@ucp.pt (Professional)

Addresses

  • IMM . Faculdade de Medicina da Universidade de Lisboa Av. Professor Egas Moniz, 1649-028 L, Lisboa, Lisboa, Portugal (Professional)
  • R Quinta Grande 6, IGC, 2780-156, Oeiras, Lisboa, Portugal (Professional)

Websites

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
English Intermediate (B1) Intermediate (B1) Intermediate (B1) Intermediate (B1)
French Beginner (A1) Intermediate (B1) Elementary (A2) Elementary (A2)
Education
Degree Classification
2018/01 - 2024/04/07
Concluded
 Biomedicina (Doutoramento)
Instituto de Medicina Molecular João Lobo Antunes, Portugal

Universidade de Lisboa Faculdade de Medicina, Portugal
"Molecular mechanisms controlling physiological and pathological angiogenesis" (THESIS/DISSERTATION)
2015
Concluded
 Bioquímica (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
"An innovative strategy for therapeutic angiogenesis: Low doses of Ionizing Radiation" (THESIS/DISSERTATION)
 17
2013
Concluded
 Bioquímica (Licenciatura)
Universidade de Lisboa Faculdade de Ciências, Portugal
"n/a" (THESIS/DISSERTATION)
 14
Affiliation

Science

Category
Host institution 		Employer
2024/01/01 - 2025/12/31 Contracted Researcher (Research) Universidade Católica Portuguesa, Portugal
Católica Biomedical Research Centre, Portugal
2018/01/01 - 2023/12/31 Researcher (Research) Instituto de Medicina Molecular João Lobo Antunes, Portugal
2015/12/01 - 2016/09/01 Researcher (Research) Universidade de Lisboa Centro Cardiovascular da Universidade de Lisboa, Portugal
2014/09/01 - 2015/11/19 Research Trainee (Research) Universidade de Lisboa Centro Cardiovascular da Universidade de Lisboa, Portugal
2013/01/01 - 2014/09/01 Research Trainee (Research) Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
Projects

Contract

Designation Funders
2024/01/01 - 2025/12/31 ECARD: Endothelial Cells as rheostats for Age-Related diseases
HR22-00551
Researcher
Ongoing
2022/04/01 - 2023/12/30 Estudo da dinâmica do pericito durante o desenvolvimento vascular
EXPL/MED-ANM/1616/2021
PhD Student Fellow
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2018/01 - 2021 Flow(in)DR
PTDC/MED-PAT/31639/2017
PhD Student Fellow
Concluded

Other

Designation Funders
2014/09 - 2015/11 Low doses of Ionizing Radiation Induce Angiogenesis: Therapeutic Implications
info:eu-repo/grantAgreement/NIH/NATIONAL CANCER INSTITUTE/5R01CA033821-03/US
Other
National Institutes of Health
2013/09 - 2014/09 The extracellular matrix modulates H2O2 degradation and redox signalling in endothelial cells
na
Other
Outputs

Publications

Conference paper
  1. Markus Koerbel; Alessandro Ciccarelli; Christopher J Peddie; Andreia Pena; Daniela Ramalho; Irene Aspalter; Claudio A Fr. "Multi-scale imaging and automated analysis of neovascular tufts". Paper presented in 2024 ARVO Annual Meeting, 2024.
Conference poster
  1. Pena, Andreia. "“NM-myosin-IIA is essential in pathological and physiological angiogenesis”". Paper presented in Endothelial Cell Phenotypes in Health and Disease, GRC, 2024.
  2. Ouarné, Marie; Ramalho, Daniela; Pena, Andreia. Corresponding author: Ramalho, Daniela. "A non-genetic model of vascular shunts informs on the cellular mechanisms of formation and resolution of arteriovenous malformations". Paper presented in Endothelial Cell Phenotypes in Health and Disease, GRC, 2024.
  3. Pena, Andreia. "A Non-genetic model of vascular shunts informs on the cellular mechanisms of formation and resolution of Arteriovenous Malformations". Paper presented in Rede Saúde, ULisboa, 2024.
  4. Ramalho, Daniela; Pena, Andreia; Nadine Conchinha; Lenka Henao Misikova; Rui Benedito; Cláudio Franco. "Migration-based mechanisms of arteriogenesis". Paper presented in Leducq Attract meeting, 2023.
  5. Pena, Andreia; Daniela Ramalho; Marie Ouarné; Nadine Conchinha; Lenka Henao Misikova; Yulia Carvalho; Ana Figueiredo; Cláudio Franco. "NM-MYOSIN-IIA IS ESSENTIAL FOR PERICYTE MIGRATION AND VASCULAR STABILITY DURING SPROUTING ANGIOGENESIS". Paper presented in Leducq Attract meeting, 2023.
  6. Pena, Andreia. "NM-Myosin-IIA is essential for PC migration and vascular stability during sprouting angiogenesis". Paper presented in Symposium in Vascular Biomedicine, Berlin, 2023.
  7. Ramalho, Daniela; Pena, Andreia; Nadine Conchinha; Lenka Misiková; Rui Benedito; Cláudio Franco. "Migration-based mechanisms of arteriogenesis". Paper presented in Leducq Attract meeting, 2022.
  8. Pena, Andreia; Pezzarossa, Anna; Franco, Cláudio. "Deregulated Endothelial Blood Flow Response as a cause of Diabetic Retinopathy". Paper presented in Leducq Attract meeting, 2022.
  9. Daniela ramalh; Pena, Andreia; Nadine Conchinha; Lenka Henao Misíková; Rui Benedito; Cláudio Franco. "Migration-based mechanisms of arteriogenesis". Paper presented in XV CAML · V NeurULisboa PhD Students, 2022.
  10. Pena, Andreia; Pezzarossa, Anna; Franco, Claudio A. "Deregulated Endothelial Blood Flow Response as a cause of Diabetic Retinopathy". Paper presented in xiii caml phd meeting, Lisbon, Portugal, 2019.
  11. Pena, Andreia; Pezzarossa, Anna; Franco, Claudio A. "Deregulated Endothelial Blood Flow Response as a cause of Diabetic Retinopathy". Paper presented in Symposia on Tumour Biology, Lisbon, Portugal, 2018.
  12. Bagulho, Ana; Vilas-Boas, Filipe; Pena, Andreia; Peneda, Catarina; Santos, Filipa C.; Jerónimo, Ana; de Almeida, Rodrigo F.M.; Real, Carla. "The extracellular matrix modulates H2O2 degradation and redox signalling in endothelial cells". Paper presented in CQB Day, Faculty of Sciences, University of Lisbon, 2015.
Journal article
  1. Marie Ouarné; Andreia Pena; Daniela Ramalho; Nadine V. Conchinha; Tiago Costa; Romain Enjalbert; Ana M. Figueiredo; et al. "A non-genetic model of vascular shunts informs on the cellular mechanisms of formation and resolution of arteriovenous malformations". Cardiovascular Research 120 15 (2024): 1967-1984. https://ciencia.ucp.pt/en/publications/40369004-c22d-4690-b66d-ad54c403db6b.
    10.1093/cvr/cvae160
  2. Catarina Sequeira; Lou Martha Wackerbarth; Andreia Pena; Mafalda Sá-Pereira; Franco CA; Edgar R. Gomes. "Myonuclear position and blood vessel organization during skeletal muscle postnatal development". Development (Cambridge) 151 19 (2024): https://ciencia.ucp.pt/en/publications/92e8262e-b48d-4502-9356-966ba1ef67ca.
    10.1242/dev.202548
  3. Holly Elizabeth Lovegrove; Sabrina Ghadaouia ; Georgia E Hulmes ; Christopher Keith Revell; Marta Giralt-Pujol; Zain Alhashem; Andreia Pena; et al. "Cell shape dynamics trigger transitions in cell state via geometric tuning of mitotic symmetry". Science (2024):
    Under revision
Newspaper article
  1. Yi Jin; Yindi Ding; Mark Richards; Mika Kaakinen; Wolfgang Giese; Elisabeth Baumann; Anna Szymborska; et al. "Tyrosine-protein kinase Yes controls endothelial junctional plasticity and barrier integrity by regulating VE-cadherin phosphorylation and endocytosis", Nature Cardiovascular Research, 2022, http://dx.doi.org/10.1038/s44161-022-00172-z.
    10.1038/s44161-022-00172-z
  2. Pedro Barbacena; Maria Dominguez-Cejudo; Catarina G. Fonseca; Manuel Gómez-González; Laura M. Faure; Georgia Zarkada; Andreia Pena; et al. "Competition for endothelial cell polarity drives vascular morphogenesis in the mouse retina", Developmental Cell, 2022, http://dx.doi.org/10.1016/j.devcel.2022.09.002.
    10.1016/j.devcel.2022.09.002
  3. Marie Ouarné; Andreia Pena; Cláudio Areias Franco. "From remodeling to quiescence: The transformation of the vascular network", Cells & Development, 2021, http://dx.doi.org/10.1016/j.cdev.2021.203735.
    10.1016/j.cdev.2021.203735
  4. Ana Figueiredo; Pedro Barbacena; Ana Russo; Silvia Vaccaro; Daniela Ramalho; Andreia Pena; Aida Pires Lima; et al. "Endothelial cell invasion is controlled by dactylopodia", Proceedings of the National Academy of Sciences, 2021, http://dx.doi.org/10.1073/pnas.2023829118.
    10.1073/pnas.2023829118
  5. Pena, Andreia; Marie Ouarné; Cláudio Areias Franco. "Methods to quantify endothelial cell front-rear polarity in vivo and in vitro", Curr Opin Hematol ., 2021
    10.1097/MOH.0000000000000643
  6. Prahst, Claudia; Ashrafzadeh, Parham; Mead, Thomas; Figueiredo, Ana; Chang, Karen; Richardson, Douglas; Venkaraman, Lakshmi; et al. "Mouse retinal cell behaviour in space and time using light sheet fluorescence microscopy", eLife, 2020, http://dx.doi.org/10.7554/elife.49779.
    10.7554/elife.49779
  7. Bagulho, Ana; Vilas-Boas, Filipe; Pena, Andreia; Peneda, Catarina; Santos, Filipa C.; Jerónimo, Ana; de Almeida, Rodrigo F.M.; Real, Carla. "The extracellular matrix modulates H2O2 degradation and redox signaling in endothelial cells", Redox Biology, 2015, http://dx.doi.org/10.1016/j.redox.2015.09.006.
    10.1016/j.redox.2015.09.006
Thesis / Dissertation
  1. "Molecular mechanisms controlling physiological and pathological angiogenesis". PhD, Universidade de Lisboa, 2023. aguarda defesa do doutoramento.
  2. Pena, Andreia. "An innovative strategy for therapeutic angiogenesis: Low doses of Ionizing Radiation". Master, Universidade de Lisboa, 2015. http://hdl.handle.net/10451/22295.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2025/02/15 A non-genetic model of vascular shunts informs on the cellular mechanisms of formation and resolution of arteriovenous malformations XV Congresso Novas Fronteiras em Medicina Cardiovascular - 8ª Edição Prémio AIDFM-CETERA
2024 A Non-genetic model of vascular shunts informs on the cellular mechanisms of formation and resolution of Arteriovenous Malformations Rede Saúde
ULisboa
2024 NM-myosin-IIA is essential in pathological and physiological angiogenesis” CBR _PhD day
2023/07 "NM-Myosin-IIA is essential for PC migration and vascular stability during sprouting angiogenesis" Leducq Attract meeting
(Berlim, Germany)
2022/11 “NM-MIIA is essential for pericyte migration and proliferation”, Católica Biomedical Research Center, 1st CBR Get-together
Universidade Catolica Portuguesa, CBR (Católica Biomedical Research Center)
2022/06 “NM-MIIA is essential for pericyte migration and proliferation” Leducq Attract meeting
(Edimburgh, United Kingdom)
2022/05 "Unveiling the effects of Myh9 in pericytes during sprouting angiogenesis" XV CAML · V NeurULisboa PhD Students
instituto de medicina molecular
2021/05 "Unveiling the effects of Myh9 in pericytes during sprouting angiogenesis" 3rd International Course on Cell Biology & Cancer
Institute Curie
2021/05 "Unveiling the effects of Myh9 in pericytes during sprouting angiogenesis" XIV CAML · IV NeurULisboa PhD Students (Virtual Meeting)
instituto de medicina molecular
2018/05/25 "Evaluating the contribution of endothelial-flow response in Diabetic Retinopathy" XII CAML PhD Meeting
(Portugal)

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2020 - 2021 Organizer of the Pizza seminars for PhD students (2020 - 2021)
Seminar (Co-organisor)
 Instituto de Medicina Molecular João Lobo Antunes, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2023 - Current Job shadowing CBR where we showeddifferent students our work and thetype of research we are doing in the lab.
Other
 Job shadowing CBR
Universidade Católica Portuguesa Campus Sintra, Portugal
2025/02/24 - 2025/02/25 Formação em Comunicação de Ciência: Comunicação oral em ciência – apresentações para audiências, narrativas e linguagem não verbal Escrita de ciência para públicos leigos – princípios de jornalismo de ciência Comunicação visual em ciência – slides e posters, outros suportes visuais
Workshop
 Formação em Comunicação de Ciência
Universidade de Lisboa, Portugal
2025/02/14 - 2025/02/16 XV Congresso Novas Fronteiras em Medicina Cardiovascular - Este Congresso visa, em primeiro lugar, promover a discussão aberta sobre novas fronteiras no que tem sido uma evolução fascinante no âmbito do diagnóstico e terapêutica cardiovascular. Nele participam um vasto número de peritos nacionais e estrangeiros, constituindo uma excelente oportunidade de formação pós-graduada na área da Medicina Cardiovascular.
Congress
 XV Congresso Novas Fronteiras em Medicina Cardiovascular
2024/09 - 2024/09 Noite Europeia dos Investigadores - NEI Oeiras 2024 Este evento visou desmistificar a investigação e aproximar a ciência do público. Noite Europeia dos Investigadores
2024/04 - 2024/04 Webinar: Managing Genetically Engineered Animals Through the Lens of the 4Rs
Workshop
 Managing Genetically Engineered Animals Through the Lens of the 4Rs
2024 - 2024 The FELASA (Federation of European Laboratory Animal Science Associations) Workshop on Severity Classification of Procedures is an event focused on discussing and establishing guidelines for categorizing the severity of experimental procedures involving laboratory animals. FELASA plays a crucial role in promoting the ethical use of animals in research and education across Europe. The severity classification of procedures is an essential aspect of animal research ethics, as it helps researchers, institutional animal care committees, and regulatory FELASA Workshop on Severity Classification of Procedures
2023/07/13 - 2023/07/13 Symposium: Vascular Biomedicine Berlin - From Cellular Networks to Systems Medicine of Vascular Malformations
Symposium
2023 - 2023 Introduction to 3D image analysis in Imaris - This course provided hands-on training in 3D image analysis via the Imaris software. It covered everything from how to get images converted to .ims format, to using the generated surfaces to analyze 3D and 4D data, including showing the new features the recently released Imaris 10 provides. This course is aimed at bioscience researchers and technicians from all levels with an interest in analyzing their 3D/4D datasets. Introduction to 3D image analysis in Imaris
2019 - 2023 Leducq ATTRACT meeting Leducq meeting
2022/01 - 2022/01 webinar on optimising animal dosing studies (Injection or Infusion? Insights for Your Next Animal Dosing Investigation)
Workshop
 Injection or Infusion? Insights for Your Next Animal Dosing Investigation
2022 - 2022 Nature masterclass - On-demand online courses Self-paced learning in convenient bite-sized units, with videos and engaging learning activities. Popular courses: Writing a Research Paper: 2nd Edition Publishing a Research Paper Persuasive Grant Writing Nature masterclass, (virtual)
2021 - 2021 3rd International Course on Cell Biology & Cancer (virtual)
Institut Curie, France
2020 - 2021 COVID-19 Diagnostic Task Force - Sample processing I Patient Diagnosis,
Other
Instituto de Medicina Molecular João Lobo Antunes, Portugal
2020 - 2021 Science Careers Workshop Series
Workshop
Instituto de Medicina Molecular João Lobo Antunes, Portugal
2019 - 2019 Workshop "Turn Yourself Into a Successful Speaker"
Workshop
 Workshop "Turn Yourself Into a Successful Speaker"
Instituto de Medicina Molecular João Lobo Antunes, Portugal
2019 - 2019 Workshop "How to represent your data"
Workshop
 Workshop "How to represent your data"
2019 - 2019 DevBioMed Symposium
Symposium
 DevBioMed Symposium
Fundação Champalimaud, Portugal
2018 - 2018 Workshop "Graphical design: How to tell a story with a picture”
Workshop
 Workshop "Graphical design: How to tell a story with a picture”
Instituto de Medicina Molecular João Lobo Antunes, Portugal
2018 - 2018 Module VI - Statistical Tests | Introduction to Clinical Research: a pratical course Module VI - Statistical Tests | Introduction to Clinical Research: a pratical course
Instituto de Medicina Molecular João Lobo Antunes, Portugal
2018 - 2018 Workshop Key Differences Among B6 Substrains: “Know Your B6 Mouse and the Research Impact” and “Strategies to Minimize Genetic Drift and Maximize Experimental Reproducibility in Mouse Research” (Charles River)
Workshop
 Workshop Key Differences Among B6 Substrains: “Know Your B6 Mouse and the Research Impact” and “Strategies to Minimize Genetic Drift and Maximize Experimental Reproducibility in Mouse Research” (Charles River)
Instituto de Medicina Molecular João Lobo Antunes, Portugal
2018 - 2018 ReTuBi Workshop on High-Resolution Light Microscopy – 2nd Edition
Workshop
 ReTuBi Workshop on High-Resolution Light Microscopy – 2nd Edition
Instituto de Medicina Molecular João Lobo Antunes, Portugal
2018 - 2018 Symposium on tumour biology: From basic biology to disease Symposium on tumour biology: From basic biology to disease
2018 - 2018 Biophysical Constraints and Evolutionary Cell Biology Workshop
Workshop
 Biophysical Constraints and Evolutionary Cell Biology Workshop
Instituto Gulbenkian de Ciência, Portugal
2018 - 2018 Cell migration under confinement Workshop
Workshop
 Cell migration under confinement Workshop
2018 - 2018 LinkedIn Workshop
Workshop
 LinkedIn Workshop
Instituto de Medicina Molecular João Lobo Antunes, Portugal
2016 - 2016 Laboratory Animal Science (FELASA Cat. B)
Other
 Laboratory Animal Science (FELASA Cat. B)
Instituto de Medicina Molecular João Lobo Antunes, Portugal
2016 - 2016 Course in Histopathology in biomedical research: Show me your mouse and will show you your phenotype
Workshop
 Course in Histopathology in biomedical research: Show me your mouse and will show you your phenotype
Instituto de Medicina Molecular João Lobo Antunes, Portugal
2015 - 2015 Synposium Thymus Synposium Thymus
Instituto de Medicina Molecular João Lobo Antunes, Portugal
2015 - 2015 Bioimaging course in microscopy Bioimaging course in microscopy
Instituto de Medicina Molecular João Lobo Antunes, Portugal
2015 - 2015 Course in Angiogenesis Course in Angiogenesis
Instituto de Medicina Molecular João Lobo Antunes, Portugal
Distinctions

Award

2025 PRÉMIO AIDFM - CETERA - Cardiovascular Research 2024 –3º lugar - Melhor Artigo Científico: A non-genetic model of vascular shunts informs on the cellular mechanisms of formation and resolution of arteriovenous malformations
2024 Best poster award “NM-myosin-IIA is essential in pathological and physiological angiogenesis”, Endothelial Cell Phenotypes in Health and Disease, GRC
2022 XV CAML · V NeurULisboa PhD Students Meeting | Award Experts Category - oral presentation

Other distinction

2017 PhD Fellowship from FCT (SFRH/BD/130635/2017 and COVID/BD/152399/2022)
Fundação para a Ciência e a Tecnologia, Portugal