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Daniela Simões has a bachelor's degree in Medicinal Chemistry (2017) and a master's degree in Applied Pharmacology (2019), both obtained at the University of Coimbra. Additionally, she is certified by DGAV to perform experimental research using animal models. After finishing her master's thesis, Daniela was granted a Master Research Fellowship (CY-SENSORS, 2021). In 2022, she obtained another Master Research grant in collaboration with a Biotech Company (Prilenia Therapeutics) in noeurosciences context. In September 2022, Daniela was granted a Master Research Fellowship included in a research project financed by the BIAL Foundation (73/20). In 2023, she joined a European project (Excellence Hubs, CHAngeing) with a Master Research grant in an ageing context. Regarding scientific output, Daniela has published 6 indexed manuscripts, 1 as first author and 1 as co-author in the "Journal of Ethnopharmacology"(IF: 5.20; Q1 in 2022 in Drug Discovery); 2 as co-author in "Natural Product Research" (IF: 2.46, Q2 in 2021 in Plant Science) and Pharmaceuticals (IF: 5.68; Q1 in 2022 in Drug Discovery and Pharmaceutical Science), respectively; 1 as first author in the journal “Behavioural Brain Research” (IF: 2.3, Q2 in 2025 in Neurosciences and Behavioral Sciences); and another as first author in the “European Journal of Clinical Investigation” (IF: 3.6, Q1 in 2025 in Medicine, General & Internal). In addition, she has participated in several national and international meetings, being the first author of 4 and co-author of 3 national oral communications (SPF); co-author of a national poster communication (Annual Meeting in Pharmaceutical Sciences 2019); author of 1 (IBERPHENOL 2020) and co-author of 6 international poster communications (IBERPHENOL 2020; FENS Regional meeting 2023; IBRO 2023; The Barcelona Blood-Brain-Barrier Conference 2025; First International Congress of the Scientific Society of Psychoneuroimmunology 2025). Daniela has also collaborated in the organization of the SPF meeting (Coimbra, February, 2023); in the supervision of undergraduate and graduate students in the laboratory; and has also participated in science communication activities for the general public. Concerning Daniela´s technical knowledge, she has developed several areas of expertise in biochemistry and molecular techniques, immunocytochemistry, immunohistochemistry, as well as the maintenance and manipulation of several animal models. Moreover, she has expertise in rodent behavioral tests, brain tissue manipulation, and the culture of primary neurons and immortalized cell lines. She also has knowledge of single-cell analysis, mitochondrial characterization techniques, live imaging techniques, and microscopy, as well as data treatment and video and image analysis.
Identificação

Identificação pessoal

Nome completo
Daniela Sofia Matias Simões

Nomes de citação

  • Daniela M. Simões
  • Daniela Simões

Identificadores de autor

Ciência ID
2819-E13B-971B
ORCID iD
0000-0002-9754-9037

Endereços de correio eletrónico

  • daniela.sm.simoes@gmail.com (Profissional)

Telefones

Telemóvel
  • 964578013 (Pessoal)

Domínios de atuação

  • Ciências Médicas e da Saúde - Medicina Básica - Neurociências
  • Ciências Médicas e da Saúde - Medicina Básica - Farmacologia e Farmácia
  • Ciências Médicas e da Saúde - Medicina Básica - Química Médica
  • Ciências da Engenharia e Tecnologias - Nanotecnologia - Nanomateriais
  • Ciências Médicas e da Saúde - Biotecnologia Médica - Tecnologias que envolvem a Manipulação de Células,Tecidos,Órgãos ou todo o Organismo
  • Ciências Médicas e da Saúde - Medicina Básica - Imunologia
  • Ciências Naturais - Ciências Biológicas - Biologia Celular
Formação
Grau Classificação
2023/11/12 - 2029
Em curso
Doctoral Programme in Health Sciences (Doutoramento)
University of Coimbra - Faculty of Medicine, Portugal
2022/08/05
Concluído
Realização de procedimentos em animais (pequenos roedores) (Outros)
Direcção-Geral de Alimentação e Veterinária, Portugal
2021/07/02 - 2021/07/29
Concluído
VIII Cell Culture and Tissue Training Course (Outros)
University of Coimbra - Faculty of Medicine, Portugal

University of Coimbra - Department of Mathematic, Portugal
2021/01/08 - 2021/02/13
Concluído
Training Course in Applied Statistics using SPSS (Outros)
University of Coimbra - Department of Mathematic, Portugal
16
2017/10/11 - 2019/07/24
Concluído
Applied Pharmacology (Mestrado)
Faculty of Pharmacy, University of Coimbra, Portugal
"Study of the vasorelaxant and antioxidant activity of Cymbopogon citratus" (TESE/DISSERTAÇÃO)
17
2019/06/26 - 2019/06/28
Concluído
Practical course on Laboratory Animal Science (Outros)
Portuguese Society of Laboratory Animal Science (SPCAL), Portugal
2014/09/26 - 2017/07/12
Concluído
Medicinal Chemistry (Licenciatura)
Faculty of Sciences and Technology, University of Coimbra, Portugal
13
Percurso profissional

Outros

Categoria Profissional
Instituição de acolhimento
Empregador
2023/09/04 - Atual European Research Fellow Universidade de Coimbra - Polo III, Portugal
Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
2022/09/15 - 2023/06/14 Research Fellow Fundação Bial, Portugal
Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra, Portugal
2022/01 - 2022/07/31 Research Fellow Prilenia Therapeutics, Israel
University of Coimbra - Center for Neuroscience and Cell Biology, Portugal
2021/01/08 - 2021/07/25 Research fellow in the CY-SENSORS project Fundação para a Ciência e a Tecnologia, Portugal
Department of Chemical Engineering, University of Coimbra, Portugal
Projetos

Bolsa

Designação Financiadores
2023/09/04 - Atual CHAngeing-Connected Hubs in Ageing: Healthy Living to Protect Cerebrovascular Function
Bolseiro de Investigação
Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra, Portugal
Em curso
2022/09/15 - 2023/06/14 Cerebrovascular hypothesis of stress-induced behavioral alterations
Bolseiro de Investigação
Em curso
2022/01 - 2022/07/31 Analysis of the effects of pridopidine, analog 1, analog 4 alone and in combination on mitochondrial function and redox changes in Huntington's disease cell models
Bolseiro de Investigação
University of Coimbra - Center for Neuroscience and Cell Biology, Portugal
Prilenia Therapeutics
Concluído
2021/01/08 - 2021/07/25 CY-SENSORS project
Bolseiro de Investigação
Department of Chemical Engineering, University of Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
Produções

Publicações

Artigo em jornal
  1. Silva, Ana Paula; Daniela M. Simões; Malva JO. "Scientific production for Comic books about the benefits of the Mediterranean diet in a regional Journal: "Dani explains, through the drawing, the Secret of the Mediterranean Diet". Illustrations by José Gomes, texts by António Piedade.", Diário de Coimbra, 2025
Artigo em revista
  1. Simões, Daniela M.; Carreira, José; Henriques, Alexandre; Gaspar, Rita; Sanches, Eliane S.; Baptista, Filipa I.; Silva, Ana Paula. "Distinct behavioural and neurovascular signatures induced by acute and chronic stress in rats". Behavioural Brain Research 493 (2025): 115706. https://doi.org/10.1016/j.bbr.2025.115706.
    Publicado • 10.1016/j.bbr.2025.115706
  2. Eliane Swely Sanches; Daniela Simões; Filipa Isabel Baptista; Ana Paula Silva. "Neurovascular dysfunction in psychiatric disorders: Underlying mechanisms and therapeutic approaches". European Journal of Clinical Investigation (2025): https://doi.org/10.1111/eci.14319.
    10.1111/eci.14319
  3. Jéssica Malheiros; Daniela M. Simões; Pedro E. Antunes; Artur Figueirinha; Maria Dulce Cotrim; Diogo A. Fonseca. "Vascular effects of Fragaria vesca L. in human arteries". Natural Product Research (2022): https://doi.org/10.1080/14786419.2022.2152448.
    10.1080/14786419.2022.2152448
  4. Jéssica Malheiros; Daniela M. Simões; Artur Figueirinha; Maria Dulce Cotrim; Diogo A. Fonseca. "Agrimonia eupatoria L.: An integrative perspective on ethnomedicinal use, phenolic composition and pharmacological activity". Journal of Ethnopharmacology (2022): https://doi.org/10.1016/j.jep.2022.115498.
    Publicado
  5. Jéssica Malheiros; Daniela M. Simões; Pedro E. Antunes; Artur Figueirinha; Diogo A. Fonseca. "Vascular Effects of Polyphenols from Agrimonia eupatoria L. and Role of Isoquercitrin in Its Vasorelaxant Potential in Human Arteries". Pharmaceuticals (2022): https://doi.org/10.3390/ph15050638.
    Publicado
  6. Daniela M. Simões; Jéssica Malheiros; Pedro Engrácia Antunes; Artur Figueirinha; Maria Dulce Cotrim; Diogo A. Fonseca. "Vascular activity of infusion and fractions of Cymbopogon citratus (DC) Stapf. in human arteries". Journal of Ethnopharmacology (2020): https://doi.org/10.1016/j.jep.2020.112947.
    Publicado
Poster em conferência
  1. Silva, Ana Paula; Daniela M. Simões; Malva JO. Autor correspondente: Silva, Ana Paula. "Effect of Mediterranean diet compounds on brain endothelial dysfunction induced by infl ammation: an in vitro study". Trabalho apresentado em The Barcelona Blood-Brain-Barrier Conference 2025, 2025.
  2. Silva, Ana Paula; Daniela Simões; Alexandre Henriques; Eliane Sanches; Filipa Baptista. "Impact of acute stress on behavior and neuroinflammation: a pre-clinical study". Trabalho apresentado em IBRO 2023 - IBRO World Congress of Neuroscience, 2023.
  3. Filipa Baptisa; Daniela Simões; Alexandre Henriques; Eliane Sanches; Silva, Ana Paula. "IMPACT OF CHRONIC STRESS IN BLOOD-BRAIN BARRIER: FOCUS ON C3 COMPLEMENT PATHWAY AND SEX DIFFERENCES". Trabalho apresentado em IBRO 2023 - IBRO World Congress of Neuroscience, 2023.
  4. Daniela Simões; Alexandre Henriques; Eliane Sanches; Filipa Baptista; Silva, Ana Paula; Daniela M. Simões; Sanches, Eliane Swely; Filipa I. Baptista; Ana Paula Silva. "ACUTE STRESS INDUCES RAT BEHAVIOURAL ALTERATIONS AND A NEUROINFLAMMATORY RESPONSE". Trabalho apresentado em FENS Regional Meeting 2023, 2023.
  5. Daniela M. Simões; Diogo A. Fonseca; Jéssica Malheiros; Pedro E. Antunes; Artur Figueirinha; Maria Dulce Cotrim. "Cymbopogon citratus (DC) Stapf.: vascular effects of tannins, flavonoids and phenolic acids in isolated human arteries". Trabalho apresentado em International IBERPHENOL Conference & Advances in the role of phenols in health effects and other uses, 2020.
  6. Jéssica Malheiros; Diogo A. Fonseca; Daniela M. Simões; Pedro E. Antunes; Artur Figueirinha; Maria Dulce Cotrim. "Vascular effects of Agrimonia eupatoria L.". Trabalho apresentado em International IBERPHENOL Conference & Advances in the role of phenols in health effects and other uses, 2020.
  7. Garrido-Matilla1 L; Vera-Fernández1 C; Sanches, ES; Daniela M. Simões; Marcos A; Ambrosio, Emilio; Ana Paula Pereira da Silva Martins. "Impact of cocaine and alcohol consumption on blood-brain barrier: from cells to animal studies.". Trabalho apresentado em Barcelona Blood-Brain Barrier Conference 2025, 2020.
  8. Jéssica Malheiros; Diogo A. Fonseca; Daniela M. Simões; Pedro Engrácia Antunes; Artur Figueirinha; Maria Dulce Cotrim. "Vascular effects of extracts from Agrimonia eupatoria L., Fragaria vesca and Urtica dioica L.". Trabalho apresentado em First Annual Meeting in Pharmaceutical Sciences, 2019.
Resumo em conferência
  1. Daniela M. Simões; Valls, Rita; Malva JO; Silva, Ana Paula. "BRAIN ENDOTHELIAL INTEGRITY AND BEHAVIORAL PERFORMANCES ARE PRESERVED BY A MEDITERRANEAN DIET COMPOUND UNDER INFLAMMATORY CONDITIONS". Trabalho apresentado em 56ª Reunião da Sociedade Portuguesa de Farmacologia, 44ª Reunião de Farmacologia Clínica e 25ª Reunião de Toxicologia, aculdade de Farmácia localizada no Pólo 3 da Universidade de Coimbra, 2026.
  2. Valls, Rita; Daniela M. Simões; Jani-sofia; Vera Sá; Ricardo A Leitão; Silva, Ana Paula. "CCR5 INVOLVEMENT IN METHAMPHETAMINE-INDUCED BBB DYSFUNCTION AND NEUROIMMUNE ALTERATIONS". Trabalho apresentado em 56ª Reunião da Sociedade Portuguesa de Farmacologia, 44ª Reunião de Farmacologia Clínica e 25ª Reunião de Toxicologia, Coimbra, 2026.
    Publicado
  3. Lucía Garrido-Matilla; Carlos Vera-Fernández; Sanches, ES; Daniela M. Simões; Alba Arranz; Alberto Marcos; Emilio Ambrosio; Silva, Ana Paula. "Blood–brain barrier alterations induced by cocaine and ethanol polyconsumption: Evidence from in vivo and in vitro models". Trabalho apresentado em First International Congress of the Scientific Society of Psychoneuroimmunology, Granada, 2025.
  4. Silva, Ana Paula; Daniela M. Simões; Malva JO. "Effect of Mediterranean diet compounds on brain endothelial dysfunction induced by inflammation: an in vitro study". Barcelona, 2025.
  5. Lucía Garrido-Matilla; Carlos Vera-Fernández; Sanches, ES; Daniela M. Simões; Alberto Marcos; Emilio Ambrosio; Silva, Ana Paula. "Impact of cocaine and alcohol consumption on blood-brain barrier: from cells to animal studies.". Trabalho apresentado em Barcelona Blood-Brain Barrier Conference, Barcelona, 2025.
  6. Daniela M. Simões; Alexandre Henriques; Sanches, Eliane Swely; Filipa I. Baptista; Ana Paula Silva. "Acute Stress Induced Rat Behavioural Alterations and Triggers a Neuroinflammatory Response". Coimbra, 2023.
  7. Daniela M. Simões; Alexandre Henriques; Sanches, Eliane Swely; Filipa I. Baptista; Ana Paula Silva. "Acute stress induces rat behavioural alterations". Albufeira, 2023.
  8. Daniela M. Simões; Alexandre Henriques; Sanches, Eliane Swely; Filipa I. Baptista; Ana Paula Silva. "Acute stress induces rat behaviural alterations and a neuroinflammatory response". Trabalho apresentado em FENS, Albufeira, 2023.
    Publicado
  9. Daniela M. Simões; Diogo A. Fonseca; Jéssica Malheiros; Pedro Engrácia Antunes; Artur Figueirinha; Maria Dulce Cotrim. "Vascular effects of infusion and fractions of Cymbopogon citratus (DC) Stapf. in isolated human thoracic arteries". Trabalho apresentado em L Annual Meeting of the Portuguese Society of Pharmacology, XXXVIII Meeting in Clinical Pharmacology and XIX Meeting in Toxicology, Coimbra, 2020.
  10. Jéssica Malheiros; Diogo A. Fonseca; Daniela M. Simões; Pedro Engrácia Antunes; Artur Figueirinha; Maria Dulce Cotrim. "Vascular effects of extracts from Agrimonia eupatoria L., Fragaria vesca L. and Urtica dioica L.". Trabalho apresentado em L Annual Meeting of the Portuguese Society of Pharmacology, XXXVIII Meeting in Clinical Pharmacology and XIX Meeting in Toxicology, Coimbra, 2020.
  11. Daniela M. Simões; Diogo A. Fonseca; Jéssica Malheiros; Pedro Engrácia Antunes; Artur Figueirinha; Maria Dulce Cotrim. "Vascular effects and antioxidant activity of Cymbogopon citratus". Trabalho apresentado em XLIX REUNIÃO SOCIEDADE PORTUGUESA DE FARMACOLOGIA, XXXVII REUNIÃO FARMACOLOGIA CLÍNICA, XVIII REUNIÃO TOXICOLOGIA,, Porto, 2019.
  12. Jéssica Malheiros; Diogo A. Fonseca; Daniela M. Simões; Pedro Engrácia Antunes; Artur Figueirinha; Maria Dulce Cotrim. "Vascular effects of extract of Agrimonia eupatoria, Fragaria vesca and Urtica dioica". Trabalho apresentado em XLIX REUNIÃO SOCIEDADE PORTUGUESA DE FARMACOLOGIA, XXXVII REUNIÃO FARMACOLOGIA CLÍNICA, XVIII REUNIÃO TOXICOLOGIA,, Porto, 2019.
Tese / Dissertação
  1. Daniela M. Simões. "Study of the vasorelaxant and antioxidant activity of Cymbopogon citratus". Mestrado, Universidade de Coimbra, 2019. http://hdl.handle.net/10316/88234.
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2026/02/05 BRAIN ENDOTHELIAL INTEGRITY AND BEHAVIORAL PERFORMANCES ARE PRESERVED BY A MEDITERRANEAN DIET COMPOUND UNDER INFLAMMATORY CONDITIONS 56ª Reunião da Sociedade Portuguesa de Farmacologia, 44ª Reunião de Farmacologia Clínica e 25ª Reunião de Toxicologia
Faculty of Pharmacy of University of Coimbra (Coimbra, Portugal)
2026/02/03 MEDITERRANEAN DIET AND BLOOD BRAIN BARRIER FUNCTION ONE HEALTH: A metabolic approach from the cell to society
Doctoral Programme in Experimental Biology and Biomedicine (Coimbra, Portugal)
2023/02/01 Acute Stress induces rat behavioural alterations and triggers a neuroinflammatory response LIII REUNIÃO SOCIEDADE PORTUGUESA DE FARMACOLOGIA, XLI REUNIÃO FARMACOLOGIA CLÍNICA, XXII REUNIÃO TOXICOLOGIA,
Sociedade Portuguesa de Farmacologia
2020/02/06 Vascular effects of infusion and fractions of Cymbopogon citratus (DC) Stapf. in isolated human thoracic arteries L REUNIÃO SOCIEDADE PORTUGUESA DE FARMACOLOGIA, XXXVIII REUNIÃO FARMACOLOGIA CLÍNICA, XIX REUNIÃO TOXICOLOGIA,
Universidade de Coimbra, Faculdade de Farmácia (Coimbra, Portugal)
2019/02/06 Vascular effects and antioxidant activity of Cymbogopon citratus XLIX REUNIÃO SOCIEDADE PORTUGUESA DE FARMACOLOGIA, XXXVII REUNIÃO FARMACOLOGIA CLÍNICA, XVIII REUNIÃO TOXICOLOGIA,
Universidade do Porto, Faculdade de Farmácia (Porto, Portugal)

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação)
Instituição / Organização
2023 - 2023 The Portuguese Society of Pharmacology (SPF) plays an extremely relevant role for the scientific development of Experimental Pharmacology, Clinical Pharmacology and Toxicology in Portugal. he Annual Meetings of the SPF are the main forum for dissemination and discussion of the progress of knowledge and research in these areas, contributing in an important way to the training of its members, particularly the youngest. (2023)
Congresso (Membro da Comissão Organizadora)
Sociedade Portuguesa de Farmacologia, Portugal

Participação em evento

Descrição da atividade
Tipo de evento
Nome do evento
Instituição / Organização
2025/09/26 - 2025/09/26 Participation at the activity 14. O escudo do nosso cérebro em perigo.
Exposição
Noite Europeia dos Investigadores
Universidade de Coimbra, Portugal
2018/09/27 - 2018/09/28 Event that highlighted the importance of partnership between university and industry. With the presence of speakers representing the pharmaceutical companies in Portugal that invest the most in R&D, nationally and internationally; speakers from several innovative start-up companies and from national research centers and universities; and speakers in leading positions in the Portuguese socio-economic panorama.
Simpósio
1st Drugs R&D PhD Symposium. Translational Science: From Academia to Industry
Faculty of Pharmacy, University of Coimbra, Portugal

Tutoria

Tópico Nome do aluno
2026/03 - Atual Mentoring of students during laboratory rotations in the Master in Biomedical Research program Margarida Cruz
2026/03 - Atual Mentoring of students during laboratory rotations in the Master in Biomedical Research program Rita Félix
2026/02 - Atual Laboratory Mentoring of BSc final traineeships Miguel Ferreira
2026/02 - Atual Laboratory mentory of applied research internships for medical students Gabriela Gomes
2025/10 - Atual Mentoring a Biomedical Pharmacy undergraduate student in a voluntary laboratory internship. Bárbara Tróia
2026/02 - 2026/03 Mentoring of students during laboratory rotations in the Master in Biomedical Molecular and Translational Neuroscience program Joana Catarino
2026/02 - 2026/02 Mentoring of students during laboratory rotations in the Master’s degree in Cellular and Molecular Biology program Eva Soliman
2025/12 - 2025/12 Mentoring of students during laboratory rotations in the Master in Cellular and Molecular biology program Letícia
2025/12 - 2025/12 Mentoring of students during laboratory rotations in the Master in Biochemistry program Beatriz Madeira
2024/09 - 2025/10 Laboratory Mentoring of Master student Rita Valls Pinto
2025/02 - 2025/06 Laboratory mentory of applied research internships for medical students Vitória Pinto
2025/03 - 2025/03 Mentoring of students during laboratory rotations in the Master in Biomedical Research program Paulo Esteves
2025/03 - 2025/03 Mentoring of students during laboratory rotations in the Master in Biomedical Research program Francisca Carriço
2025/01 - 2025/01 Mentoring of students during laboratory rotations in the Master in Biomedical Molecular and Translational Neuroscience program Gilda Miranda
2023/09 - 2024/09 Laboratory Mentoring of Master student Amélia Ormonde
2024/04 - 2024/05 Mentoring of students during laboratory rotations in the Master in Biomedical Research program Márcia Nicolau
2024/02 - 2024/05 Laboratory mentory of applied research internships for medical students Luciana
2024/02 - 2024/02 Mentoring of students during laboratory rotations in the Master in Biomedical Research program Brendo Alvarenga
2022/09 - 2023/10 Laboratory Mentoring of Master student Alexandre Henriques
2022/09 - 2023/10 Laboratory Mentoring of Master student Laura Nóbrega
2023/02 - 2023/06 Laboratory mentory of applied research internships for medical students Sofia Marques
2023/02 - 2023/05 Laboratory Mentoring of BSc final traineeships Vanessa Marques
2023/03/01 - 2023/03/30 Laboratory Mentoring of BSc final traineeships Ana Sofia Sousa
2022/09 - 2022/11 Laboratory mentory of applied research internships for medical students Inês Jordão