Daniela Sofia Matias Simões (2819-E13B-971B)

Curriculum Vitae

Daniela Sofia Matias Simões

Daniela Simões has a bachelor's degree in Medicinal Chemistry (2017) and a master's degree in Applied Pharmacology (2019), both obtained at the University of Coimbra. Additionally, she is a certified researcher by DGAV to develop experimental research with animal models. After finishing her master thesis, Daniela was granted with a Master Research Fellow (CY-SENSORS, 2021). In 2022, she obtained another Master Research grant in collaboration with a Biotech Company (Prilenia Therapeutics) in noeurosciences context. Last September (2022), Daniela was granted with a Master Research Fellow included in a research project financed by BIAL Foundation (73/20). Regarding scientific output, Daniela has published 4 indexed manuscripts, 1 as first author and 1 as co-author in the "Journal of Ethnopharmacology"(IF: 5.20; Q1 in 2022 in Drug Discovery) and another 2 as co-author in "Natural Product Research" (IF: 2.46, Q2 in 2021 in Plant Science) and in Pharmaceuticals (IF: 5.68; Q1 in 2022 in Drug Discovery and Pharmaceutical Science), respectively. In addition, she participated in several national and international meetings, being the first author of 3 and co-author of 2 national oral communications (SPF); author of 1 (IBERPHENOL) and co-author of 2 international poster communication [IBERPHENOL; and another to be presented in May (FENS Regional meeting)]; and co-author of another national poster communication (Annual Meeting in Pharmaceutical Sciences). Daniela has also collaborated in the organization of the SPF meeting (Coimbra, February, 2023); in the supervision of undergraduate and graduate students in the laboratory; and has also participated in science communication activities to the general public. Concerning Daniela´s technical knowledge, she has developed several expertise in biochemistry and molecular techniques, immunocytochemistry, immunohistochemistry, as well as maintenance and manipulation of several animal models. Moreover, she has expertise in rodent behavioral tests, brain tissue manipulation, culture of primary neurons, as well as immortalized cell lines. She has also knowledge in single-cell analysis, mitochondrial characterization techniques, live imaging techniques and microscopy, as well as data treatment and video and image analysis.

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Identificação

Identificação pessoal

Nome completo: Daniela Sofia Matias Simões

Nomes de citação

Daniela M. Simões

Identificadores de autor

Ciência ID: 2819-E13B-971B
ORCID iD: 0000-0002-9754-9037

Endereços de correio eletrónico

daniela.sm.simoes@gmail.com (Profissional)

Telefones

Telemóvel

964578013 (Pessoal)

Domínios de atuação

Ciências Médicas e da Saúde - Medicina Básica - Neurociências
Ciências Médicas e da Saúde - Medicina Básica - Farmacologia e Farmácia
Ciências Médicas e da Saúde - Medicina Básica - Química Médica
Ciências da Engenharia e Tecnologias - Nanotecnologia - Nanomateriais
Ciências Médicas e da Saúde - Biotecnologia Médica - Tecnologias que envolvem a Manipulação de Células,Tecidos,Órgãos ou todo o Organismo
Ciências Médicas e da Saúde - Medicina Básica - Imunologia
Ciências Naturais - Ciências Biológicas - Biologia Celular

Formação

	Grau	Classificação
2022/08/05 Concluído	Realização de procedimentos em animais (pequenos roedores) (Outros) Direcção-Geral de Alimentação e Veterinária, Portugal
2021/07/02 - 2021/07/29 Concluído	VIII Cell Culture and Tissue Training Course (Outros) University of Coimbra - Faculty of Medicine, Portugal University of Coimbra - Department of Mathematic, Portugal
2021/01/08 - 2021/02/13 Concluído	Training Course in Applied Statistics using SPSS (Outros) University of Coimbra - Department of Mathematic, Portugal	16
2017/10/11 - 2019/07/24 Concluído	Applied Pharmacology (Mestrado) Faculty of Pharmacy, University of Coimbra, Portugal "Study of the vasorelaxant and antioxidant activity of Cymbopogon citratus" (TESE/DISSERTAÇÃO)	17
2019/06/26 - 2019/06/28 Concluído	Practical course on Laboratory Animal Science (Outros) Portuguese Society of Laboratory Animal Science (SPCAL), Portugal
2014/09/26 - 2017/07/12 Concluído	Medicinal Chemistry (Licenciatura) Faculty of Sciences and Technology, University of Coimbra, Portugal	13

Percurso profissional

Outros

	Categoria Profissional Instituição de acolhimento	Empregador
2022/09/15 - Atual	Research Fellow	Fundação Bial, Portugal
	Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra, Portugal
2022/01 - 2022/07/31	Research Fellow	Prilenia Therapeutics, Israel
	University of Coimbra - Center for Neuroscience and Cell Biology, Portugal
2021/01/08 - 2021/07/25	Research fellow in the CY-SENSORS project	Fundação para a Ciência e a Tecnologia, Portugal
	Department of Chemical Engineering, University of Coimbra, Portugal

Projetos

Bolsa

	Designação	Financiadores
2022/09/15 - 2023/06/15	Cerebrovascular hypothesis of stress-induced behavioral alterations Bial 73/20 Bolseiro de Investigação	Em curso
2022/01 - 2022/07/31	Analysis of the effects of pridopidine, analog 1, analog 4 alone and in combination on mitochondrial function and redox changes in Huntington's disease cell models Prilenia Therapeutics Bolseiro de Investigação University of Coimbra - Center for Neuroscience and Cell Biology, Portugal	Prilenia Therapeutics Concluído
2021/01/08 - 2021/07/25	CY-SENSORS project PTDC/BTA-GES/32359/2017\| POCI-01-0145-FEDER-032359 Bolseiro de Investigação Department of Chemical Engineering, University of Coimbra, Portugal	Fundação para a Ciência e a Tecnologia Concluído

Produções

Publicações

Artigo em revista	Jéssica Malheiros; Daniela M. Simões; Pedro E. Antunes; Artur Figueirinha; Maria Dulce Cotrim; Diogo A. Fonseca. "Vascular effects of Fragaria vesca L. in human arteries". Natural Product Research (2022): https://doi.org/10.1080/14786419.2022.2152448. 10.1080/14786419.2022.2152448 Jéssica Malheiros; Daniela M. Simões; Artur Figueirinha; Maria Dulce Cotrim; Diogo A. Fonseca. "Agrimonia eupatoria L.: An integrative perspective on ethnomedicinal use, phenolic composition and pharmacological activity". Journal of Ethnopharmacology (2022): https://doi.org/10.1016/j.jep.2022.115498. Publicado Jéssica Malheiros; Daniela M. Simões; Pedro E. Antunes; Artur Figueirinha; Diogo A. Fonseca. "Vascular Effects of Polyphenols from Agrimonia eupatoria L. and Role of Isoquercitrin in Its Vasorelaxant Potential in Human Arteries". Pharmaceuticals (2022): https://doi.org/10.3390/ph15050638. Publicado Daniela M. Simões; Jéssica Malheiros; Pedro Engrácia Antunes; Artur Figueirinha; Maria Dulce Cotrim; Diogo A. Fonseca. "Vascular activity of infusion and fractions of Cymbopogon citratus (DC) Stapf. in human arteries". Journal of Ethnopharmacology (2020): https://doi.org/10.1016/j.jep.2020.112947. Publicado
Poster em conferência	Daniela M. Simões; Diogo A. Fonseca; Jéssica Malheiros; Pedro E. Antunes; Artur Figueirinha; Maria Dulce Cotrim. "Cymbopogon citratus (DC) Stapf.: vascular effects of tannins, flavonoids and phenolic acids in isolated human arteries". Trabalho apresentado em International IBERPHENOL Conference & Advances in the role of phenols in health effects and other uses, 2020. Jéssica Malheiros; Diogo A. Fonseca; Daniela M. Simões; Pedro E. Antunes; Artur Figueirinha; Maria Dulce Cotrim. "Vascular effects of Agrimonia eupatoria L.". Trabalho apresentado em International IBERPHENOL Conference & Advances in the role of phenols in health effects and other uses, 2020. Jéssica Malheiros; Diogo A. Fonseca; Daniela M. Simões; Pedro Engrácia Antunes; Artur Figueirinha; Maria Dulce Cotrim. "Vascular effects of extracts from Agrimonia eupatoria L., Fragaria vesca and Urtica dioica L.". Trabalho apresentado em First Annual Meeting in Pharmaceutical Sciences, 2019.
Resumo em conferência	Daniela M. Simões; Alexandre Henriques; Sanches, Eliane Swely; Filipa I. Baptista; Ana Paula Silva. "Acute Stress Induced Rat Behavioural Alterations and Triggers a Neuroinflammatory Response". Trabalho apresentado em LIII REUNIÃO SOCIEDADE PORTUGUESA DE FARMACOLOGIA, XLI REUNIÃO FARMACOLOGIA CLÍNICA, XXII REUNIÃO TOXICOLOGIA,, Coimbra, 2023. Publicado Daniela M. Simões; Alexandre Henriques; Sanches, Eliane Swely; Filipa I. Baptista; Ana Paula Silva. "Acute stress induces rat behaviural alterations and a neuroinflammatory response". Trabalho apresentado em FENS, Albufeira, 2023. Aceite para publicação Daniela M. Simões; Diogo A. Fonseca; Jéssica Malheiros; Pedro Engrácia Antunes; Artur Figueirinha; Maria Dulce Cotrim. "Vascular effects of infusion and fractions of Cymbopogon citratus (DC) Stapf. in isolated human thoracic arteries". Trabalho apresentado em L Annual Meeting of the Portuguese Society of Pharmacology, XXXVIII Meeting in Clinical Pharmacology and XIX Meeting in Toxicology, Coimbra, 2020. Jéssica Malheiros; Diogo A. Fonseca; Daniela M. Simões; Pedro Engrácia Antunes; Artur Figueirinha; Maria Dulce Cotrim. "Vascular effects of extracts from Agrimonia eupatoria L., Fragaria vesca L. and Urtica dioica L.". Trabalho apresentado em L Annual Meeting of the Portuguese Society of Pharmacology, XXXVIII Meeting in Clinical Pharmacology and XIX Meeting in Toxicology, Coimbra, 2020. Daniela M. Simões; Diogo A. Fonseca; Jéssica Malheiros; Pedro Engrácia Antunes; Artur Figueirinha; Maria Dulce Cotrim. "Vascular effects and antioxidant activity of Cymbogopon citratus". Trabalho apresentado em XLIX REUNIÃO SOCIEDADE PORTUGUESA DE FARMACOLOGIA, XXXVII REUNIÃO FARMACOLOGIA CLÍNICA, XVIII REUNIÃO TOXICOLOGIA,, Porto, 2019. Jéssica Malheiros; Diogo A. Fonseca; Daniela M. Simões; Pedro Engrácia Antunes; Artur Figueirinha; Maria Dulce Cotrim. "Vascular effects of extract of Agrimonia eupatoria, Fragaria vesca and Urtica dioica". Trabalho apresentado em XLIX REUNIÃO SOCIEDADE PORTUGUESA DE FARMACOLOGIA, XXXVII REUNIÃO FARMACOLOGIA CLÍNICA, XVIII REUNIÃO TOXICOLOGIA,, Porto, 2019.
Tese / Dissertação	Daniela M. Simões. "Study of the vasorelaxant and antioxidant activity of Cymbopogon citratus". Mestrado, Universidade de Coimbra, 2019. http://hdl.handle.net/10316/88234.

Atividades

Apresentação oral de trabalho

	Título da apresentação	Nome do evento Anfitrião (Local do evento)
2023/02/01	Acute Stress induces rat behavioural alterations and triggers a neuroinflammatory response	LIII REUNIÃO SOCIEDADE PORTUGUESA DE FARMACOLOGIA, XLI REUNIÃO FARMACOLOGIA CLÍNICA, XXII REUNIÃO TOXICOLOGIA, Sociedade Portuguesa de Farmacologia
2020/02/06	Vascular effects of infusion and fractions of Cymbopogon citratus (DC) Stapf. in isolated human thoracic arteries	L REUNIÃO SOCIEDADE PORTUGUESA DE FARMACOLOGIA, XXXVIII REUNIÃO FARMACOLOGIA CLÍNICA, XIX REUNIÃO TOXICOLOGIA, Universidade de Coimbra, Faculdade de Farmácia (Coimbra, Portugal)
2019/02/06	Vascular effects and antioxidant activity of Cymbogopon citratus	XLIX REUNIÃO SOCIEDADE PORTUGUESA DE FARMACOLOGIA, XXXVII REUNIÃO FARMACOLOGIA CLÍNICA, XVIII REUNIÃO TOXICOLOGIA, Universidade do Porto, Faculdade de Farmácia (Porto, Portugal)

Organização de evento

	Nome do evento Tipo de evento (Tipo de participação)	Instituição / Organização
2023 - 2023	The Portuguese Society of Pharmacology (SPF) plays an extremely relevant role for the scientific development of Experimental Pharmacology, Clinical Pharmacology and Toxicology in Portugal. he Annual Meetings of the SPF are the main forum for dissemination and discussion of the progress of knowledge and research in these areas, contributing in an important way to the training of its members, particularly the youngest. (2023) Congresso (Membro da Comissão Organizadora)	Sociedade Portuguesa de Farmacologia, Portugal

Participação em evento

	Descrição da atividade Tipo de evento	Nome do evento Instituição / Organização
2018/09/27 - 2018/09/28	Event that highlighted the importance of partnership between university and industry. With the presence of speakers representing the pharmaceutical companies in Portugal that invest the most in R&D, nationally and internationally; speakers from several innovative start-up companies and from national research centers and universities; and speakers in leading positions in the Portuguese socio-economic panorama. Simpósio	1st Drugs R&D PhD Symposium. Translational Science: From Academia to Industry Faculty of Pharmacy, University of Coimbra, Portugal

Tutoria

	Tópico	Nome do aluno
2023/01 - Atual	Laboratory Mentoring of BSc final traineeships	Vanessa Marques
2022/10 - Atual	Laboratory Mentoring of BSc traineeships	Sofia Marques
2022/09 - Atual	Laboratory Mentoring of Master student	Alexandre Henriques
2022/09 - Atual	Laboratory Mentoring of Master student	Laura Nóbrega
2023/03/01 - 2023/03/30	Laboratory Mentoring of BSc final traineeships	Ana Sofia Sousa