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Daniela Simões has a bachelor's degree in Medicinal Chemistry (2017) and a master's degree in Applied Pharmacology (2019), both obtained at the University of Coimbra. Additionally, she is a certified researcher by DGAV to develop experimental research with animal models. After finishing her master thesis, Daniela was granted with a Master Research Fellow (CY-SENSORS, 2021). In 2022, she obtained another Master Research grant in collaboration with a Biotech Company (Prilenia Therapeutics) in noeurosciences context. Last September (2022), Daniela was granted with a Master Research Fellow included in a research project financed by BIAL Foundation (73/20). Regarding scientific output, Daniela has published 4 indexed manuscripts, 1 as first author and 1 as co-author in the "Journal of Ethnopharmacology"(IF: 5.20; Q1 in 2022 in Drug Discovery) and another 2 as co-author in "Natural Product Research" (IF: 2.46, Q2 in 2021 in Plant Science) and in Pharmaceuticals (IF: 5.68; Q1 in 2022 in Drug Discovery and Pharmaceutical Science), respectively. In addition, she participated in several national and international meetings, being the first author of 3 and co-author of 2 national oral communications (SPF); author of 1 (IBERPHENOL) and co-author of 2 international poster communication [IBERPHENOL; and another to be presented in May (FENS Regional meeting)]; and co-author of another national poster communication (Annual Meeting in Pharmaceutical Sciences). Daniela has also collaborated in the organization of the SPF meeting (Coimbra, February, 2023); in the supervision of undergraduate and graduate students in the laboratory; and has also participated in science communication activities to the general public. Concerning Daniela´s technical knowledge, she has developed several expertise in biochemistry and molecular techniques, immunocytochemistry, immunohistochemistry, as well as maintenance and manipulation of several animal models. Moreover, she has expertise in rodent behavioral tests, brain tissue manipulation, culture of primary neurons, as well as immortalized cell lines. She has also knowledge in single-cell analysis, mitochondrial characterization techniques, live imaging techniques and microscopy, as well as data treatment and video and image analysis.
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Identification

Personal identification

Full name
Daniela Sofia Matias Simões

Citation names

  • Daniela M. Simões

Author identifiers

Ciência ID
2819-E13B-971B
ORCID iD
0000-0002-9754-9037

Email addresses

  • daniela.sm.simoes@gmail.com (Professional)

Telephones

Mobile phone
  • 964578013 (Personal)

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Neurosciences
  • Medical and Health Sciences - Basic Medicine - Pharmacology and pharmacy
  • Medical and Health Sciences - Basic Medicine - Medicinal Chemistry
  • Engineering and Technology - Nano-technology - Nano-materials
  • Medical and Health Sciences - Medical Biotechnology - Technologies Involving the Manipulation of Cells, Tissues, Organs or the Whole Organism
  • Medical and Health Sciences - Basic Medicine - Immunology
  • Natural sciences - Biological Sciences - Cell Biology
Education
Degree Classification
2022/08/05
Concluded
 Realização de procedimentos em animais (pequenos roedores) (Outros)
Direcção-Geral de Alimentação e Veterinária, Portugal
2021/07/02 - 2021/07/29
Concluded
 VIII Cell Culture and Tissue Training Course (Outros)
University of Coimbra - Faculty of Medicine, Portugal

University of Coimbra - Department of Mathematic, Portugal
2021/01/08 - 2021/02/13
Concluded
 Training Course in Applied Statistics using SPSS (Outros)
University of Coimbra - Department of Mathematic, Portugal
 16
2017/10/11 - 2019/07/24
Concluded
 Applied Pharmacology (Mestrado)
Faculty of Pharmacy, University of Coimbra, Portugal
"Study of the vasorelaxant and antioxidant activity of Cymbopogon citratus" (THESIS/DISSERTATION)
 17
2019/06/26 - 2019/06/28
Concluded
 Practical course on Laboratory Animal Science (Outros)
Portuguese Society of Laboratory Animal Science (SPCAL), Portugal
2014/09/26 - 2017/07/12
Concluded
 Medicinal Chemistry (Licenciatura)
Faculty of Sciences and Technology, University of Coimbra, Portugal
 13
Affiliation

Others

Category
Host institution 		Employer
2022/09/15 - Current Research Fellow Fundação Bial, Portugal
Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra, Portugal
2022/01 - 2022/07/31 Research Fellow Prilenia Therapeutics, Israel
University of Coimbra - Center for Neuroscience and Cell Biology, Portugal
2021/01/08 - 2021/07/25 Research fellow in the CY-SENSORS project Fundação para a Ciência e a Tecnologia, Portugal
Department of Chemical Engineering, University of Coimbra, Portugal
Projects

Grant

Designation Funders
2022/09/15 - 2023/06/15 Cerebrovascular hypothesis of stress-induced behavioral alterations
Bial 73/20
Research Fellow
Ongoing
2022/01 - 2022/07/31 Analysis of the effects of pridopidine, analog 1, analog 4 alone and in combination on mitochondrial function and redox changes in Huntington's disease cell models
Prilenia Therapeutics
Research Fellow
University of Coimbra - Center for Neuroscience and Cell Biology, Portugal
 Prilenia Therapeutics
Concluded
2021/01/08 - 2021/07/25 CY-SENSORS project
PTDC/BTA-GES/32359/2017| POCI-01-0145-FEDER-032359
Research Fellow
Department of Chemical Engineering, University of Coimbra, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Conference abstract
  1. Daniela M. Simões; Alexandre Henriques; Sanches, Eliane Swely; Filipa I. Baptista; Ana Paula Silva. "Acute Stress Induced Rat Behavioural Alterations and Triggers a Neuroinflammatory Response". Paper presented in LIII REUNIÃO SOCIEDADE PORTUGUESA DE FARMACOLOGIA, XLI REUNIÃO FARMACOLOGIA CLÍNICA, XXII REUNIÃO TOXICOLOGIA,, Coimbra, 2023.
    Published
  2. Daniela M. Simões; Alexandre Henriques; Sanches, Eliane Swely; Filipa I. Baptista; Ana Paula Silva. "Acute stress induces rat behaviural alterations and a neuroinflammatory response". Paper presented in FENS, Albufeira, 2023.
    Accepted
  3. Daniela M. Simões; Diogo A. Fonseca; Jéssica Malheiros; Pedro Engrácia Antunes; Artur Figueirinha; Maria Dulce Cotrim. "Vascular effects of infusion and fractions of Cymbopogon citratus (DC) Stapf. in isolated human thoracic arteries". Paper presented in L Annual Meeting of the Portuguese Society of Pharmacology, XXXVIII Meeting in Clinical Pharmacology and XIX Meeting in Toxicology, Coimbra, 2020.
  4. Jéssica Malheiros; Diogo A. Fonseca; Daniela M. Simões; Pedro Engrácia Antunes; Artur Figueirinha; Maria Dulce Cotrim. "Vascular effects of extracts from Agrimonia eupatoria L., Fragaria vesca L. and Urtica dioica L.". Paper presented in L Annual Meeting of the Portuguese Society of Pharmacology, XXXVIII Meeting in Clinical Pharmacology and XIX Meeting in Toxicology, Coimbra, 2020.
  5. Daniela M. Simões; Diogo A. Fonseca; Jéssica Malheiros; Pedro Engrácia Antunes; Artur Figueirinha; Maria Dulce Cotrim. "Vascular effects and antioxidant activity of Cymbogopon citratus". Paper presented in XLIX REUNIÃO SOCIEDADE PORTUGUESA DE FARMACOLOGIA, XXXVII REUNIÃO FARMACOLOGIA CLÍNICA, XVIII REUNIÃO TOXICOLOGIA,, Porto, 2019.
  6. Jéssica Malheiros; Diogo A. Fonseca; Daniela M. Simões; Pedro Engrácia Antunes; Artur Figueirinha; Maria Dulce Cotrim. "Vascular effects of extract of Agrimonia eupatoria, Fragaria vesca and Urtica dioica". Paper presented in XLIX REUNIÃO SOCIEDADE PORTUGUESA DE FARMACOLOGIA, XXXVII REUNIÃO FARMACOLOGIA CLÍNICA, XVIII REUNIÃO TOXICOLOGIA,, Porto, 2019.
Conference poster
  1. Daniela M. Simões; Diogo A. Fonseca; Jéssica Malheiros; Pedro E. Antunes; Artur Figueirinha; Maria Dulce Cotrim. "Cymbopogon citratus (DC) Stapf.: vascular effects of tannins, flavonoids and phenolic acids in isolated human arteries". Paper presented in International IBERPHENOL Conference & Advances in the role of phenols in health effects and other uses, 2020.
  2. Jéssica Malheiros; Diogo A. Fonseca; Daniela M. Simões; Pedro E. Antunes; Artur Figueirinha; Maria Dulce Cotrim. "Vascular effects of Agrimonia eupatoria L.". Paper presented in International IBERPHENOL Conference & Advances in the role of phenols in health effects and other uses, 2020.
  3. Jéssica Malheiros; Diogo A. Fonseca; Daniela M. Simões; Pedro Engrácia Antunes; Artur Figueirinha; Maria Dulce Cotrim. "Vascular effects of extracts from Agrimonia eupatoria L., Fragaria vesca and Urtica dioica L.". Paper presented in First Annual Meeting in Pharmaceutical Sciences, 2019.
Journal article
  1. Jéssica Malheiros; Daniela M. Simões; Pedro E. Antunes; Artur Figueirinha; Maria Dulce Cotrim; Diogo A. Fonseca. "Vascular effects of Fragaria vesca L. in human arteries". Natural Product Research (2022): https://doi.org/10.1080/14786419.2022.2152448.
    10.1080/14786419.2022.2152448
  2. Jéssica Malheiros; Daniela M. Simões; Artur Figueirinha; Maria Dulce Cotrim; Diogo A. Fonseca. "Agrimonia eupatoria L.: An integrative perspective on ethnomedicinal use, phenolic composition and pharmacological activity". Journal of Ethnopharmacology (2022): https://doi.org/10.1016/j.jep.2022.115498.
    Published
  3. Jéssica Malheiros; Daniela M. Simões; Pedro E. Antunes; Artur Figueirinha; Diogo A. Fonseca. "Vascular Effects of Polyphenols from Agrimonia eupatoria L. and Role of Isoquercitrin in Its Vasorelaxant Potential in Human Arteries". Pharmaceuticals (2022): https://doi.org/10.3390/ph15050638.
    Published
  4. Daniela M. Simões; Jéssica Malheiros; Pedro Engrácia Antunes; Artur Figueirinha; Maria Dulce Cotrim; Diogo A. Fonseca. "Vascular activity of infusion and fractions of Cymbopogon citratus (DC) Stapf. in human arteries". Journal of Ethnopharmacology (2020): https://doi.org/10.1016/j.jep.2020.112947.
    Published
Thesis / Dissertation
  1. Daniela M. Simões. "Study of the vasorelaxant and antioxidant activity of Cymbopogon citratus". Master, Universidade de Coimbra, 2019. http://hdl.handle.net/10316/88234.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2023/02/01 Acute Stress induces rat behavioural alterations and triggers a neuroinflammatory response LIII REUNIÃO SOCIEDADE PORTUGUESA DE FARMACOLOGIA, XLI REUNIÃO FARMACOLOGIA CLÍNICA, XXII REUNIÃO TOXICOLOGIA,
Sociedade Portuguesa de Farmacologia
2020/02/06 Vascular effects of infusion and fractions of Cymbopogon citratus (DC) Stapf. in isolated human thoracic arteries L REUNIÃO SOCIEDADE PORTUGUESA DE FARMACOLOGIA, XXXVIII REUNIÃO FARMACOLOGIA CLÍNICA, XIX REUNIÃO TOXICOLOGIA,
Universidade de Coimbra, Faculdade de Farmácia (Coimbra, Portugal)
2019/02/06 Vascular effects and antioxidant activity of Cymbogopon citratus XLIX REUNIÃO SOCIEDADE PORTUGUESA DE FARMACOLOGIA, XXXVII REUNIÃO FARMACOLOGIA CLÍNICA, XVIII REUNIÃO TOXICOLOGIA,
Universidade do Porto, Faculdade de Farmácia (Porto, Portugal)

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2023 - 2023 The Portuguese Society of Pharmacology (SPF) plays an extremely relevant role for the scientific development of Experimental Pharmacology, Clinical Pharmacology and Toxicology in Portugal. he Annual Meetings of the SPF are the main forum for dissemination and discussion of the progress of knowledge and research in these areas, contributing in an important way to the training of its members, particularly the youngest. (2023)
Congress (Member of the Organising Committee)
 Sociedade Portuguesa de Farmacologia, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2018/09/27 - 2018/09/28 Event that highlighted the importance of partnership between university and industry. With the presence of speakers representing the pharmaceutical companies in Portugal that invest the most in R&D, nationally and internationally; speakers from several innovative start-up companies and from national research centers and universities; and speakers in leading positions in the Portuguese socio-economic panorama.
Symposium
 1st Drugs R&D PhD Symposium. Translational Science: From Academia to Industry
Faculty of Pharmacy, University of Coimbra, Portugal

Mentoring / Tutoring

Topic Student name
2023/01 - Current Laboratory Mentoring of BSc final traineeships Vanessa Marques
2022/10 - Current Laboratory Mentoring of BSc traineeships Sofia Marques
2022/09 - Current Laboratory Mentoring of Master student Alexandre Henriques
2022/09 - Current Laboratory Mentoring of Master student Laura Nóbrega
2023/03/01 - 2023/03/30 Laboratory Mentoring of BSc final traineeships Ana Sofia Sousa