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João Peça is Assistant Professor of Molecular and Cell Biology at the University of Coimbra. He completed his Ph.D. at Duke University in 2011, where he created and used the first transgenic mice for channelrhodopsin-2 in optogenetic-assisted dissection of neuronal circuitry. In 2011, he moved to MIT as a postdoc and characterized the Shank3 animal models for autism, uncovering a new role for cortico-striatal dysfunction in autism spectrum disorders. In 2013 he was awarded a position as "FCT Investigator" and, in 2018 started an independent group as Principal Investigator at the Center for Neuroscience and Cell Biology, University of Coimbra. As main advisor (co-advisor), he has completed the supervision of 3 (+2) Ph.D. students thesis and the supervision of 10 (+1) M.Sc. students. He is/was Principal investigator/Scientist-in-charge in 8 projects, co-PI in 6, and member of the research team in 2 research projects. Present interests of his group at the University of Coimbra, center on using advanced models to understand how synaptic computations give rise to neuropsychiatric and developmental disorders and uncover how genetic and environmental elements translate into abnormal network activity. To achieve this, he uses a combination of molecular genetics, optogenetics and electrophysiological approaches using animal models and human brain organoids. To date João Peça has accrued >3200 citations and has led to primary research papers in high-impact, peer-reviewed journals, including Nature, Nature Communications, PNAS, and Neuron, and review work in Current Opinion in Neurobiology, Cell and Annual Reviews in Neuroscience. As a PI he was named "FCT Investigator", was awarded a Marie Curie Career Integration Grant, a NARSAD Young Investigator Award, and a prize from the Gulbenkian Foundation. In 2020 he received an IBRO Early Career Award. His recent work was also acknowledged with the "2019 Pfizer Prize" in Basic Research, the oldest and one of the most prestigious prizes in Portugal in the area of Biomedical Sciences. His group is composed of 5 PhD holding members and is funded by grants and awards from FCT, H2020, Bial Foundation, Takeda, IBRO and Pfizer.
Identificação

Identificação pessoal

Nome completo
João Peça

Nomes de citação

  • Peça, João

Identificadores de autor

Ciência ID
2516-567A-D39A
ORCID iD
0000-0003-4989-2129

Endereços de correio eletrónico

  • jmpessa@gmail.com (Profissional)
  • jpeca@uc.pt (Profissional)

Telefones

Telefone
  • 304502912 (Profissional)

Moradas

  • Center for Neuroscience and Cell Biology, Rua Larga, FMUC, 205b, 3004-504, Coimbra, Coimbra, Portugal (Profissional)

Websites

  • https://pt.linkedin.com/in/jo%C3%A3o-pe%C3%A7a-6a8b89a (Profissional)
  • www.pecalab.com (Académico)

Domínios de atuação

  • Ciências Médicas e da Saúde - Medicina Básica - Neurociências

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português (Idioma materno)
Inglês Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Formação
Grau Classificação
2013
Concluído
Postdoctoral Fellow (Postgraduate Certificate)
Massachusetts Institute of Technology, Estados Unidos
2011
Concluído
Neurobiology (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Duke University, Estados Unidos
"Genetic and optogenetic engineering as a strategy to probe neuronal circuits" (TESE/DISSERTAÇÃO)
Com Distinção e Louvor | Summa cum laude
2004
Concluído
Bioquímica (Licenciatura)
Universidade de Coimbra, Portugal
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento
Empregador
2018/02/01 - 2019/08/31 Investigador principal (carreira) (Investigação) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2013/07/01 - 2018/01/31 Investigador Auxiliar (carreira) (Investigação) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2011/03/11 - 2013/12/31 Pós-doutorado (Investigação) Massachusetts Institute of Technology, Estados Unidos
2005/06/01 - 2011/03/11 Investigador visitante (Investigação) Duke University, Estados Unidos

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento
Empregador
2019/09/01 - Atual Professor Auxiliar (Docente Universitário) Universidade de Coimbra, Portugal
2018 - 2019/08/31 Professor Auxiliar Convidado (Docente Universitário) Universidade de Coimbra, Portugal

Cargos e Funções

Categoria Profissional
Instituição de acolhimento
Empregador
2021/09/15 - Atual Coordinator of the Master Degree in Cellular and Molecular Biology Universidade de Coimbra, Portugal
Universidade de Coimbra, Portugal
2020/09/22 - Atual Member of the Board of Directors Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Outros

Categoria Profissional
Instituição de acolhimento
Empregador
2018/02/01 - Atual Group Leader Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Projetos

Bolsa

Designação Financiadores
2021 - Atual Postnatal Reorganization of the cerebellum via Neuron-microglia interaction: IL-4 as a mediator between ADHD and allergies
PTDC/MED-NEU/5993/2020
Investigador responsável
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
2021 - Atual The social code in cingulate-hippocampal circuits
#074/2020
Investigador responsável
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação Bial
2020 - Atual IBRO Early Carrer Award - Deficits in mGluR activity in GPRASP2 mutant mice
ECA
Investigador responsável
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
International Brain Research Organization
2020 - Atual A Saúde no Saber
45-2019/478
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Ciência Viva
2019 - 2022 Syn2Psy - Synaptic Dysfunction in Neuropsychiatric Disorders
H2020-MSCA-ITN-2018-813986
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
EU Framework Programme for Research and Innovation Marie Sklodowska-Curie Actions
2018 - 2021/09/30 Alternate SNAPs in neurotransmitter release: from molecular function to neurocognitive dysfunction
PTDC/BIA-CEL/29451/2017
Investigador
Fundação para a Ciência e a Tecnologia
2018 - 2021/06/30 Cognitive disorders as defects in synaptic function: insight from human mutations in the CACNG2 gene
PTDC/MED-NEU/28541/2017
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
2018 - 2021/06 BrainEdition: remotely controlling gene edition in neural stem cells
PTDC/NAN-MAT/28060/2017
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
2018 - 2020 ProTeAN - Production and Testing of humAn-derived Neurons and brain organoids: advanced model probing in neurodevelopmental disorders
MSCA-IF-EF-RI-799164
Orientador
European Commission
2017 - 2020 BrainHealth2020: Early Detection, Neuromodulation and Advanced Therapies to Brain Disorders
CENTRO-01-0145-FEDER-000008
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
CENTRO2020

FEDER - Fundo Europeu de Desenvolvimento Regional
2018 - 2019/09 Exploring striatal postsynaptic SAPAP3 in Huntington’s disease
Grant Number: 948
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
EHDN-European Huntington’s Disease Network
2017 - 2019 Early life stress and social hierarchies: the role of cortico-striatal circuits
216/16
Investigador responsável
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação Bial
2017 - 2019 The influence of maternal bonding in neuroimmune synaptic sculpting
264/2016
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação Bial
2016 - 2019 Social hierarchy and early life adversity: optogenetic modulation of prefrontal cortical circuits and neuroepigenetic regulation
PTDC/NEU-SCC/3247/2014
Investigador responsável
Secretaria de Estado de Ciência Tecnologia e Ensino Superior
2014 - 2017 NARSAD Young Investigator Grant
20733
Investigador responsável
Brain and Behavior Research Foundation
2013 - 2017 CELLSYNCIRCUITS: Cellular and synaptic dissection of the neuronal circuits of social and autistic behavior
PCIG13-GA-2013-618525
Investigador responsável
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
EU Framework Programme for Research and Innovation Marie Sklodowska-Curie Actions
2011 - 2012 Autism Speaks Translational Fellow: Neural circuits of social behavior
7649
Investigador responsável
Massachusetts Institute of Technology, Estados Unidos

Projeto

Designação Financiadores
2021 - Atual Does healthy microglia rescue neuroinflammation and synaptic dysfunction in human cerebral organoids with FTD-associated mutations?
2020_119
Investigador responsável
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Takeda Pharmaceutical Company Limited

Outro

Designação Financiadores
2019 - Atual Pfizer Award 2019 in Basic Research
2019 / Basic Research
Investigador responsável
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Pfizer Portugal
2013 - 2018 FCT Investigator Award
IF/00812/2012/CP0151/CT0001
Investigador responsável
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2016 - 2017 AidToC - Ab initio designed Tools for optogenetic Control of retinal circuits
141733
Orientador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação Calouste Gulbenkian
2013 - 2014/12/31 PROJECTO ESTRATÉGICO - LA 1 - 2013-2014 PEst-C/SAU/LA0001/2013
Pest-C/SAU/LA0001/2013-2014
Investigador
CNC.IBILI, Portugal
Fundação para a Ciência e a Tecnologia
Produções

Publicações

Artigo em conferência
  1. Costa, Jéssica; Guedes, Joana; Franco, Lara; Peça, João; Cardoso, Ana Luísa. "Microglia morphology and density analysis: using stereology and 3D reconstruction to study the neuroimmune impact of early life stress". Trabalho apresentado em Paper presented in 52th International Congress on Microscopy and Microanalysis, Coimbra, 2018.
  2. Viegas, Ana Teresa; Carmona, Vítor; Almeida, Luis; Oliveira, Catarina Resende; Magalhães, João; Peça, João; Cardoso, Ana Luísa. "MicroRNA contribution in a new therapeutic strategy for Alzheimer’s disease". Trabalho apresentado em The 2016 Alzheimer’s Disease Congress, London, 2016.
Artigo em revista
  1. Jéssica Costa; Solange Martins; Pedro A. Ferreira; Ana M.S. Cardoso; Joana R. Guedes; João Peça; Ana L. Cardoso. "The old guard: Age-related changes in microglia and their consequences". Mechanisms of Ageing and Development 197 (2021): 111512-111512. https://doi.org/10.1016/j.mad.2021.111512.
    10.1016/j.mad.2021.111512
  2. Sequeira, Diana B.; Oliveira, Ana Rafaela; Seabra, Catarina M.; Palma, Paulo J.; Ramos, Carlos; Figueiredo, Maria H.; Santos, Ana C.; et al. "Regeneration of pulp-dentin complex using human stem cells of the apical papilla: in vivo interaction with two bioactive materials". Clinical Oral Investigations (2021): http://dx.doi.org/10.1007/s00784-021-03840-9.
    10.1007/s00784-021-03840-9
  3. Ribeiro, Luís F.; Catarino, Tatiana; Carvalho, Mário; Cortes, Luísa; Santos, Sandra D.; Opazo, Patricio O.; Ribeiro, Lyn Rosenbrier; et al. "Ligand-independent activity of the ghrelin receptor modulates AMPA receptor trafficking and supports memory formation". Science Signaling 14 670 (2021): eabb1953. http://dx.doi.org/10.1126/scisignal.abb1953.
    10.1126/scisignal.abb1953
  4. Lemos, Filipe; Prins, Caio; Carpi-Santos, Raul; Waclawiak, Ingrid; Sofia, Santos; Bernardes, Emerson; Peça, João; et al. "Galectin-3 in the Gut-liver axis Regulates Autistic-like Behaviors by Mechanism Associated with Cerebral Shank-3+ cell Niches in BALB/c Mice". Preprint (2021):
    Submetido
  5. Li, Yinqing; Lopez-Huerta, Violeta G.; Adiconis, Xian; Levandowski, Kirsten; Choi, Soonwook; Simmons, Sean K.; Arias-Garcia, Mario A.; et al. "Distinct subnetworks of the thalamic reticular nucleus". Nature 583 7818 (2020): 819-824. http://dx.doi.org/10.1038/s41586-020-2504-5.
    10.1038/s41586-020-2504-5
  6. Franco, Lara O.; Carvalho, Mário J.; Costa, Jéssica; Ferreira, Pedro A.; Guedes, Joana R.; Sousa, Renato; Edfawy, Mohamed; et al. "Social subordination induced by early life adversity rewires inhibitory control of the prefrontal cortex via enhanced Npy1r signaling". Neuropsychopharmacology 45 9 (2020): 1438-1447. http://dx.doi.org/10.1038/s41386-020-0727-7.
    Acesso aberto • 10.1038/s41386-020-0727-7
  7. Barros-Viegas, Ana Teresa; Carmona, Vítor; Ferreiro, Elisabete; Guedes, Joana; Cardoso, Ana Maria; Cunha, Pedro; Pereira de Almeida, Luís; et al. "miRNA-31 Improves Cognition and Abolishes Amyloid-ß Pathology by Targeting APP and BACE1 in an Animal Model of Alzheimer’s Disease". Molecular Therapy - Nucleic Acids 19 (2020): 1219-1236. http://dx.doi.org/10.1016/j.omtn.2020.01.010.
    Acesso aberto • 10.1016/j.omtn.2020.01.010
  8. Ribeiro, L.F.; Catarino, Tatiana; Carvalho, Mário Jorge da Silva; Santos, Sandra; Cortes, Luisa; Opazo, P. O.; Ribeiro., L. R.; et al. "Constitutive ghrelin receptor activity modulates AMPA receptor traffic and supports memory formation". bioRxiv (2020):
    Acesso aberto • Submetido
  9. Franco, Lara Oliveira; Carvalho, Mário Jorge da Silva; Costa, Jéssica; Ferreira, Pedro; Sousa, Renato; Guedes, Joana; Edfawy, Mohamed; et al. "Social subordination induced by early life adversity rewires inhibitory control of the prefrontal cortex via enhanced Npy1r signaling". Neuropsychopharmacology (2020):
    Acesso aberto • Em revisão
  10. Lima Caldeira, Gladys; Peça, João; Carvalho, Ana Luísa. "New insights on synaptic dysfunction in neuropsychiatric disorders". Current Opinion in Neurobiology 57 (2019): 62-70. http://dx.doi.org/10.1016/j.conb.2019.01.004.
    10.1016/j.conb.2019.01.004
  11. Edfawy, Mohamed; Guedes, Joana R.; Pereira, Marta I.; Laranjo, Mariana; Carvalho, Mário J.; Gao, Xian; Ferreira, Pedro A.; et al. "Abnormal mGluR-mediated synaptic plasticity and autism-like behaviours in Gprasp2 mutant mice". Nature Communications 10 1 (2019): http://dx.doi.org/10.1038/s41467-019-09382-9.
    10.1038/s41467-019-09382-9
  12. Sequeira, Diana; Seabra, Catarina; Palma, Paulo; Cardoso, Ana; Peça, João; Santos, João. "Effects of a New Bioceramic Material on Human Apical Papilla Cells". Journal of Functional Biomaterials 9 4 (2018): 74. http://dx.doi.org/10.3390/jfb9040074.
    10.3390/jfb9040074
  13. Santos, Tiago; Ferreira, Raquel; Quartin, Emanuel; Boto, Carlos; Saraiva, Cláudia; Bragança, José; Peça, João; et al. "Blue light potentiates neurogenesis induced by retinoic acid-loaded responsive nanoparticles". Acta Biomaterialia 59 (2017): 293-302. http://dx.doi.org/10.1016/j.actbio.2017.06.044.
    Publicado • 10.1016/j.actbio.2017.06.044
  14. Ting, Jonathan T.*; Peça, João*; Feng, Guoping. "Functional Consequences of Mutations in Postsynaptic Scaffolding Proteins and Relevance to Psychiatric Disorders". Annual Review of Neuroscience 35 1 (2012): 49-71. http://dx.doi.org/10.1146/annurev-neuro-062111-150442.
    10.1146/annurev-neuro-062111-150442
  15. Peça, J.; Feng, G.. "Cellular and synaptic network defects in autism". Current Opinion in Neurobiology 22 5 (2012): 866-872. http://www.scopus.com/inward/record.url?eid=2-s2.0-84867426528&partnerID=MN8TOARS.
    10.1016/j.conb.2012.02.015
  16. Peça, J.; Ting, J.; Feng, G.. "SnapShot: Autism and the synapse". Cell 147 3 (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-84855174133&partnerID=MN8TOARS.
    10.1016/j.cell.2011.10.015
  17. Peça, J.; Feng, G.. "Neuroscience: When lights take the circuits out". Nature 477 7363 (2011): 165-166. http://www.scopus.com/inward/record.url?eid=2-s2.0-80052602669&partnerID=MN8TOARS.
    10.1038/477165a
  18. Peça, J.; Feliciano, C.; Ting, J.T.; Wang, W.; Wells, M.F.; Venkatraman, T.N.; Lascola, C.D.; Fu, Z.; Feng, G.. "Shank3 mutant mice display autistic-like behaviours and striatal dysfunction". Nature 472 7344 (2011): 437-442. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955536349&partnerID=MN8TOARS.
    10.1038/nature09965
  19. Arenkiel, Benjamin R.; Peça, João. "Using Light to Reinstate Respiratory Plasticity". Journal of Neurophysiology 101 4 (2009): 1695-1698. http://dx.doi.org/10.1152/jn.00009.2009.
    Acesso aberto • 10.1152/jn.00009.2009
  20. Welch, Jeffrey M.; Lu, Jing; Rodriguiz, Ramona M.; Trotta, Nicholas C.; Peca, Joao; Ding, Jin-Dong; Feliciano, Catia; et al. "Cortico-striatal synaptic defects and OCD-like behaviours in Sapap3-mutant mice". Nature 448 7156 (2007): 894-900. http://dx.doi.org/10.1038/nature06104.
    10.1038/nature06104
  21. Wang, H.*; Peca, J.*; Matsuzaki, M.*; Matsuzaki, K.; Noguchi, J.; Qiu, L.; Wang, D.; et al. "High-speed mapping of synaptic connectivity using photostimulation in Channelrhodopsin-2 transgenic mice". Proceedings of the National Academy of Sciences 104 19 (2007): 8143-8148. http://dx.doi.org/10.1073/pnas.0700384104.
    Acesso aberto • 10.1073/pnas.0700384104
  22. Arenkiel, Benjamin R.; Peca, Joao; Davison, Ian G.; Feliciano, Catia; Deisseroth, Karl; Augustine, George J.; Ehlers, Michael D.; Feng, Guoping. "In Vivo Light-Induced Activation of Neural Circuitry in Transgenic Mice Expressing Channelrhodopsin-2". Neuron 54 2 (2007): 205-218. http://dx.doi.org/10.1016/j.neuron.2007.03.005.
    Acesso aberto • Publicado • 10.1016/j.neuron.2007.03.005
Capítulo de livro
  1. Peça, João. "O Cérebro Social". In Cérebro – mais vasto que o céu. OECD, 2019.
    Publicado
  2. Caldeira, Gladys; Carvalho, Ana Luísa; Peça, João. "Esquizofrenia". In Neurociências, editado por Duarte, Carlos; Rego, Cristina. Portugal: Lidel, 2017.
    Publicado
  3. Fernandes, Joana; Franco, Lara; Peça, João. "Transtorno do espectro do autismo". In Neurociências, editado por Duarte, Carlos; Rego, Cristina; Oliveira, Catarina. Portugal: Lidel, 2017.
    Publicado
  4. Heyer, M.P.; Feliciano, C.; Peca, J.; Feng, G.. "Elucidating Gene Function through use of Genetically Engineered Mice". In Neurociências. 2010.
    10.1002/9780470711675.ch10
Edição de número de revista
  1. Xu, Junyu; Shi, Lei; Peça, João. "Autism Spectrum Disorder: New Insights Into Molecular Pathophysiology and Therapeutic Development". Frontiers in Cellular Neuroscience (2020):
    Publicado
Tese / Dissertação
  1. Peça, João. "Genetic and optogenetic engineering as a strategy to probe neuronal circuits". Doutoramento, 2011.
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2021/05/07 Reprogramming and stem cells in neurodevelopmental disorders X Seminário da Sociedade de Pediatria do Neurodesenvolvimento
(online)
2019/10/12 Cerebral organoids as research tools for neurodevelopmental disorders Grupo de Estudos de Envelhecimento Cerebral e Demência
Grupo de Estudos de Envelhecimento Cerebral e Demência (Curia)
2019 Abnormal mGlur-mediated synaptic plasticity and autism-like behaviours in Gprasp2 mutant mice Spring Meeting of the International Graduate School in Molecular Medicine Ulm University
Ulm University (Ulm, Alemanha)
2019 Metabotropic glutamate receptors as a common dysfunction in neurodevelopmental disorders Invited Seminar
University of Edinburgh (Edinburgh, Reino Unido)
2019 Rain Man - Discussão sobre um filme que incide sobre autismo e Síndrome Savant "Cérebro mais vasto que o céu" - The brain at the movies -
Gulbenkian Foundation (Lisbon, Portugal)
2018 mGluR signaling in Autism Spectrum Disorders ECMED Summer School– Extracellular Matrix in Epileptogenesis
ECMED ITN (Warsaw, Polónia)
2017 Genetic dissection of Neuronal Circuits in autism spectrum disorders In4Med Congress
Medical Student Association - Faculty of Medicine, University of Coimbra (Coimbra, Portugal)
2016 Disruption of the mGLuR signaling network - a molecular focal point for ASDs Neurodevelopmental Disorders: from neuroscience to the clinic
Champalimaud Foundation & PIN (Progresso Infantil) (Lisbon, Portugal)
2016 Disruption of the mGluR signaling network - A molecular focal point for ASDs - II Simpósio de pós-graduação em Biomedicina
Universidade de Aveiro (Aveiro, Portugal)
2016 GPCR associated proteins - GPRASPing mGluR signalling dysfunction in autism spectrum disorders Society of Neuroscience: Nanosymposium on Molecular and Cellular Mechanisms in Autism Models and other Developmental Diseases
Society of Neuroscience (San Diego, Estados Unidos)
2014 Neuronal and Gene Networks Regulating Social Behavior XVIII Congress of the Portuguese Society for Biochemistry
Portuguese Society for Biochemistry (Coimbra, Portugal)
2011 Genetic and optogenetic engineering to manipulate and probe neuronal circuits and behavior IX Encontro Anual do CNC
Centro de Neurociências e Biologia Celular (Coimbra, Portugal)
2011 Shank synaptic genes in autism: Human genetics to mouse models and therapeutics IMFAR - 2011 International Meeting for Autism Research
(San Diego, Estados Unidos)

Orientação

Título / Tema
Papel desempenhado
Curso (Tipo)
Instituição / Organização
2019 - 2020 Impact of early-life stress on microglia: Neuron dynamics in the medial prefrontal cortex
Coorientador de Solange Martins Nogueira
Universidade de Coimbra, Portugal
2018 - 2019 Microglia-mediated remodelling of the cerebellar circuit
Orientador de Pedro António Cruz Ferreira
Biologia Celular e Molecular (Mestrado)
Universidade de Coimbra, Portugal
2017 - 2018 Optogenetic modulation of corticoestriatal activity for the regulation of social dominance
Orientador de José Pedro Pinto Sampaio
Biologia Celular e Molecular (Mestrado)
Universidade de Coimbra, Portugal
2017 - 2018 The role of GPRASP2 on mGluR5 signalling
Orientador de Mariana Barradas Serrano Laranjo
Biologia Celular e Molecular (Mestrado)
Universidade de Coimbra, Portugal
2014 - 2018 Long-term impact of early life stress on adult social behavior and prefrontal cortical circuits
Orientador de Lara Oliveira Franco
Biologia Experimental e Biomedicina (Doutoramento)
Universidade de Coimbra, Portugal
2016 - 2017 Characterization of Gprasp2 knockout mice as a new model for autism spectrum disorders
Orientador de Marta Isabel Ferreira Leite Pereira
Biologia Celular e Molecular (Mestrado)
Universidade de Coimbra, Portugal
2016 - 2017 The role of cortico-striatal circuits in social hierarchies
Orientador de Tiago João Dos Santos Reis
Biologia Celular e Molecular (Mestrado)
Universidade de Coimbra, Portugal
2013 - 2017 Dissecting the role of GPRASP2 in autism spectrum disorder and intellectual disability
Orientador de Mohamed Edfawy Soliman Hussien
Biologia Experimental e Biomedicina (Doutoramento)
Universidade de Coimbra, Portugal
2013 - 2017 The role of stargazin in the pathogenesis of psychiatric disorders
Coorientador de Gladys Tarcila Lima Caldeira
Biologia Experimental e Biomedicina (Doutoramento)
Universidade de Coimbra, Portugal
2015 - 2016 Dissection of hierarchy formation in mice: behavioral and molecular correlates of dominance
Orientador de Renato José Melo Sousa
Biologia Celular e Molecular (Mestrado)
Universidade de Coimbra, Portugal
2014 - 2015 Optogenetics and biotechnology : production and in vitro characterization of Ab-Initio designed channelrhodopsin-2 mutants
Orientador
Biotecnologia Farmacêutica (Mestrado)
Universidade de Coimbra, Portugal
2013 - 2014 Intelligent design of color-tuned ChR2 variants for optogenetics applications
Orientador de Bruno Cruz
Biologia Celular e Molecular (Mestrado)
Universidade de Coimbra, Portugal
2013 - 2014 Molecular mechanisms of the synaptic and cognitive effects of ghrelin
Orientador de Mário Jorge Da Silva Carvalho
Biologia Celular e Molecular (Mestrado)
Universidade de Coimbra, Portugal
2013 - 2014 Expression and purification of Channelrhodopsin-2 in Pichia pastoris: generation of blue-shifted and redshifted optogenetic variants
Orientador de Fabio Mazza
Biologia Celular e Molecular (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação)
Instituição / Organização
2014 - Atual Neuronal Circuits and Behavior: Advanced course (2014)
Oficina (workshop) (Presidente da Comissão Organizadora)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2020 - 2021 XVI Meeting of the Portuguese Society for Neuroscience (2020 - 2021)
Encontro (Membro da Comissão Organizadora)
Sociedade Portuguesa de Neurociências, Portugal
2016/07 - 2016/07 7th ISN Special Neurochemistry Conference (2016/07 - 2016/07)
Conferência (Coorganizador)
International Society for Neurochemistry, Suiça

Júri de grau académico

Tema
Tipo de participação
Nome do candidato (Tipo de grau)
Instituição / Organização
2021/11/23 Phenotypic architecture and genetic polymorphisms associated with social behaviour in Zebrafish
Arguente principal
Cláudia Gonçalves (Doutoramento)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2021/11/22 Unravelling the activity patterns of midbrain dopaminergic neurons during male sexual behaviour
Arguente principal
Silvana da Costa Araújo (Doutoramento)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2021/04/28 Striatal plasticity upon learning of a lateralized motor task
Arguente principal
Ana Margarida Pinto (Mestrado)
Universidade Nova de Lisboa, Portugal
2021/02/26 Cell-type specific neuronal manipulation of cortex and striatum during action selection
Arguente principal
Rodrigo Ferreira Mantins (Mestrado)
2020/12/17 Cell-type specificity of cortico-cortical connections between the visual and retrosplenial cortices of the mouse
Arguente
Ana Beatriz Simões Sá e Moura (Mestrado)
Universidade de Coimbra, Portugal
2020/12/14 Revealing the role of neocortical circuit defects in cognitive alterations in autism spectrum disorder
Arguente principal
Maria José Gueidão Costa (Mestrado)
Universidade de Coimbra, Portugal
2020/11/02 Analysis of the hippocampal and cortex proteome of mice exposed to psychotropic medication
Arguente
Cátia João Monteiro da Santa (Doutoramento)
Universidade de Coimbra, Portugal
2020/07/07 Oxytocinergic modulation of social information use in threat perception
Arguente principal
Ibukun Dorcas Fatunke Akinrinade (Doutoramento)
Universidade Nova de Lisboa, Portugal
2020/07/02 Cortico-hippocampal interactions as a neural substrate for the retrieval of contextual memories in choice behavior
Arguente
Emanuel Ferreira Fernandes (Doutoramento)
Universidade Nova de Lisboa, Portugal
2020/06/29 Impact of human iPSC-derived NESC transplantation in MJD-associated neuropathology and motor impairments
Arguente principal
Ana Catarina Paulino do Ó Vinhas (Mestrado)
Universidade de Coimbra, Portugal
2020/06/19 Role of TET3 enzyme in brain function
Arguente principal
Cláudia Antunes (Doutoramento)
Universidade do Minho, Portugal
2020/01/13 The Computational Roles of Dopamine and Serotonin in Tourette Syndrome and Obsessive-Compulsive Disorder
Vogal
Vasco Manuel Aranha da Conceição (Doutoramento)
Universidade de Lisboa, Portugal
2019 Mate choice and social preference in Mus musculus females
Arguente principal
Luís Fernando Gomes Moreira (Doutoramento)
Universidade Nova de Lisboa, Portugal
2019 Mechanisms of Self-Defense Suppression of Mothers Under Threat in the Presence of Offspring
Arguente principal
Elizabeth Maria Rickenbacher (Doutoramento)
Universidade Nova de Lisboa, Portugal
2019 The Computational Roles of Dopamine and Serotonin in Tourette Syndrome and Obsessive-Compulsive Disorder
Arguente
Vasco Manuel Aranha da Conceição (Doutoramento)
Universidade de Lisboa Faculdade de Medicina, Portugal
2019 Investigating potential treatment strategies and underlying mechanisms in the Fragile X Syndrome mouse and rat models
Arguente principal
Melania Muscas (Doutoramento)
The University of Edinburgh, Reino Unido
2019 Neurobehavioural and molecular mechanisms of social learning in zebrafish
Arguente principal
Júlia Sabrina Ferreira Pinho (Doutoramento)
Instituto Universitário de Ciências Psicológicas Sociais e da Vida, Portugal
2019 Targeting adenosine A2A receptors to manage Angelman syndrome symptoms
Arguente principal
Ana Teresa Capitão Moreira de Sá (Mestrado)
Universidade de Coimbra, Portugal
2019 Investigating the structural and physiological properties of ventromedial hypothalamic neurons across the estrous cycle of female mice
Arguente principal
Ines Correia Dias (Mestrado)
Universidade de Coimbra, Portugal
2018/12/20 Role of laterodorsal tegmentum in motivation and reward
Arguente principal
Bárbara Guimarães Salazar Coimbra (Doutoramento)
Universidade do Minho, Portugal
2018 Measuring dopamine release in different domains of the striatum during the development of habitual reward seeking.
Arguente principal
João Manuel Silveira De Matos (Mestrado)
Universidade de Coimbra, Portugal
2018 Mapping the neural circuitry underlying spatial and temporal locomotor adaptation
Arguente principal
Marta Rocha Maciel (Mestrado)
Universidade de Coimbra, Portugal
2017 The Role of the PgR+ cells of the Ventromedial Hypothalamus (VMHvl) in Female Mice Sexual Receptivity
Arguente principal
Inês Mendes Preguiça (Mestrado)
Universidade de Coimbra, Portugal
2017 Unravelling the circuits involved in ejaculation in mice (Mus musculus)
Arguente principal
Ana Rita Pimentel Mendes (Mestrado)
Universidade de Coimbra, Portugal
2016 Role of Nucleus accumbens dopamine D1- and D2-expressing neurons in reward and motivation
Arguente principal
Carina Isabel Soares Da Cunha (Doutoramento)
Universidade do Minho, Portugal
2016 Contribution of the ventro-lateral periaqueductal grey matter to fear conditioned analgesia
Arguente principal
Nanci Aléxia Vieira Winke (Mestrado)
Universidade de Coimbra, Portugal
2015 Contextualizing experience: plasticity pf cortical and subcortical systems for controlling auditory perception
Arguente
Ana Raquel Oliveira Martins (Doutoramento)
Universidade de Coimbra, Portugal
2015 Neural and behavioral correlates of decision confidence.
Arguente
Gil Miguel Pereira da Costa (Doutoramento)
Universidade de Coimbra, Portugal
2015 The role of serotonin in behavior: Shining light on the maestro of the brain
Arguente
Patrícia Correia (Doutoramento)
Universidade Nova de Lisboa, Portugal
2015 Synaptic and circuitry mechanisms of basal ganglia dysfunction in compulsive and repetitive behavior
Arguente
Patrícia Isabel Rodrigues Monteiro (Doutoramento)
Universidade de Coimbra, Portugal
2015 Estudo da potencial toxicidade do processo de silenciamento da ataxina 3 mutante humana mediado por shRNA lentiviral
Arguente principal
José Miguel Antunes Codêsso (Mestrado)
Universidade de Coimbra, Portugal
2015 GADD45ß : a novel long-term memory mediator
Arguente principal
David Vilhena Catarino Brito (Mestrado)
Universidade de Coimbra, Portugal
2015 Dissociating the role of interneurons in sensory processing
Arguente principal
Inês Vitória Barreiros (Mestrado)
Universidade de Coimbra, Portugal
2015 Circuit plasticity during up-states in mouse barrel cortex
Arguente principal
Emanuel Oliveira (Mestrado)
Universidade de Coimbra, Portugal
2014 Dimensions of compulsivity – on the relation between compulsive grooming, anxiety and cognitive flexibility, and the effect of deep brain stimulation
Arguente principal
Cindy Maria De Oliveira Pinhal (Mestrado)
Universidade de Coimbra, Portugal
2014 Prosocial choice in rats depends on rewards received and food-seeking behaviour displayed by recipients
Arguente principal
Diana Paula Ferreira Da Costa (Mestrado)
Universidade de Coimbra, Portugal
2013 Epileptogenesis and Therapeutic Options in a Tuberous Sclerosis Complex Epilepsy Mouse Model
Arguente principal
Catia Alexandra Pinho Silva (Mestrado)
Universidade de Coimbra, Portugal
2013 Mapping the Serotonergic System : Topographical Organization of Serotonergic Projections from the Dorsal Raphe Nucleus
Arguente principal
Katherine Louise Turco (Mestrado)
Universidade de Coimbra, Portugal

Arbitragem científica em conferência

Nome da conferência Local da conferência
2019/05 - Atual XVI Meeting of the Portuguese Society for Neuroscience
2021/03/10 - 2021/03/31 Brain Gain - Brain Awareness Week Center for Neuroscience and Cell Biology

Arbitragem científica em revista

Nome da revista (ISSN) Editora
2020 - Atual Frontiers in Behavioral Neuroscience Frontiers
2019 - Atual Frontiers in Cellular Neuroscience (1662-5102) Frontiers Media SA

Comissão de avaliação

Descrição da atividade
Tipo de assessoria
Instituição / Organização Entidade financiadora
2013 - Atual Ad Hoc reviewer for: Nature, Nature Neuroscience, Nature Medicine, Molecular Psychiatry, Neuron, Molecular Autism, PLOS One, Nature Communications, Journal of Pediatric Genomics, Journal of Neuroscience Methods, Frontiers in Cellular Neuroscience

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2020/11/12 - 2020/11/12 Advanced Imaging Methods in Neuroscience: Optogenetic labeling for monitoring and control of neuronal activity Optogenetic labeling for monitoring and control of neuronal activity (Doutoramento) Universidade de Coimbra, Portugal

Entrevista / Programa (rádio / tv)

Programa Tema
2020/11 - 2020/11 A Saúde no Saber As vacinas causam autismo?
2019/12/11 - 2019/12/11 RTP 1 - Main Portuguese TV Channel - Outras Histórias - O Código do Autismo Autism
2019/12/04 - 2019/12/04 SIC Noticias - National TV News channel Autism
2014/11/13 - 2014/11/13 "Até os ratos são generosos" - TSF - Portuguese Radio Station Commentary on prosocial behavior
2008/09/12 - 2008/09/12 "Loucura Consciente" - TSF - Portuguese Radio Station Commentary on obsessive compulsive disorder reporting by TSF, Portugal

Membro de associação

Nome da associação Tipo de participação
2016 - Atual Society for Neuroscience Member
2016 - Atual International Society for Neurochemistry Member
2013 - Atual Portuguese Society for Neuroscience Member

Outro júri / avaliação

Descrição da atividade Instituição / Organização
2019 - Atual Grant Reviewer Agence nationale de la recherche, França
2019 - Atual Evaluator for FCT Grants - Final progress report Fundação para a Ciência e a Tecnologia, Portugal
2018 - Atual Grant Reviewer Graduate Women in Science, Estados Unidos

Tutoria

Tópico Nome do aluno
2017 - Atual Postdoctoral Fellow Joana Guedes
2017 - Atual Postdoctoral Fellow Catarina Seabra
Distinções

Prémio

2020 IBRO Early Career Award
International Brain Research Organization, França
2020 FENS-IBRO/PERC
Federation of European Neuroscience Societies, Bélgica
2019 Prizer Prize
Pfizer Portugal, Portugal
2014 NARSAD Young Investigator Award
Brain and Behavior Research Foundation, Estados Unidos

Título

2013 FCT Investigator
Fundação para a Ciência e a Tecnologia, Portugal
2011 Autism Speaks Translational Fellow
Autism Speaks, Estados Unidos