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João Peça (40M) is a neurobiologist with more than 15 years of research experience. Presently, he is Assistant Professor of Molecular and Cell Biology at the University of Coimbra and Group Leader of the Neuronal Circuits and Behavior Lab. João completed his Ph.D. at Duke University in 2011, where he created the first transgenic mice for channelrhodopsin-2 and pioneered the field of optogenetics. He did his postdoc at MIT characterizing animal models for autism, where he uncovered a new role for cortico-striatal dysfunction in autism spectrum disorders. In 2013 he was awarded a position as "FCT Investigator" in Portugal and in 2018 was offered a position as Principal Investigator to start an independent group at the Center for Neuroscience and Cell Biology, University of Coimbra. He has completed the supervision of 5 Ph.D. students' thesis and the supervision of 11 M.Sc. students. He is/was Principal investigator/Scientist-in-charge in 9 projects, co-PI in 6, and member of the research team in 2 research projects. Present interests of his group center on using advanced models to understand how genetic and environmental elements risk factors translate to neurodevelopmental and neuropsychiatric disorders. To achieve this, João uses a combination of molecular genetics, optogenetics and electrophysiological approaches using animal models and human brain organoids. To date his work has accrued >3600 citations and has led to primary research papers in high-impact, peer-reviewed journals, including Nature, Nature Communications, Molecular Psychiatry, PNAS, and Neuron, and review work in Current Opinion in Neurobiology, Cell and Annual Reviews in Neuroscience. He was awarded a Marie Curie Career Integration Grant, a NARSAD Young Investigator Award, and a prize from the Gulbenkian Foundation. In 2020 he received an IBRO Early Career Award. His recent work was also acknowledged with the "2019 Pfizer Prize" in Basic Research, the oldest and one of the most prestigious prizes in Portugal in the area of Biomedical Sciences. His group is composed of 5 PhD holding members and is funded by grants and awards from FCT, H2020, Bial Foundation, Takeda, IBRO, Pfizer and is also the coordinator of the ERA-Net Neuron Project "SHANKAstro".
Identification

Personal identification

Full name
João Peça

Citation names

  • Peça, João

Author identifiers

Ciência ID
2516-567A-D39A
ORCID iD
0000-0003-4989-2129

Email addresses

  • jmpessa@gmail.com (Professional)
  • jpeca@uc.pt (Professional)

Telephones

Telephone
  • 304502912 (Professional)

Addresses

  • Center for Neuroscience and Cell Biology, Rua Larga, FMUC, 205b, 3004-504, Coimbra, Coimbra, Portugal (Professional)

Websites

  • www.pecalab.com (Scholar)
  • https://pt.linkedin.com/in/jo%C3%A3o-pe%C3%A7a-6a8b89a (Professional)

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Neurosciences

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Education
Degree Classification
2013
Concluded
Postdoctoral Fellow (Postgraduate Certificate)
Massachusetts Institute of Technology, United States
2011
Concluded
Neurobiology (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Duke University, United States
"Genetic and optogenetic engineering as a strategy to probe neuronal circuits" (THESIS/DISSERTATION)
Com Distinção e Louvor | Summa cum laude
2004
Concluded
Bioquímica (Licenciatura)
Universidade de Coimbra, Portugal
Affiliation

Science

Category
Host institution
Employer
2018/02/01 - 2019/08/31 Principal Investigator (Research) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2013/07/01 - 2018/01/31 Auxiliary Researcher (Research) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2011/03/11 - 2013/12/31 Postdoc (Research) Massachusetts Institute of Technology, United States
2005/06/01 - 2011/03/11 Visiting Researcher (Research) Duke University, United States

Teaching in Higher Education

Category
Host institution
Employer
2019/09/01 - Current Assistant Professor (University Teacher) Universidade de Coimbra, Portugal
2018 - 2019/08/31 Invited Assistant Professor (University Teacher) Universidade de Coimbra, Portugal

Positions / Appointments

Category
Host institution
Employer
2022 - Current Member of the Board of Education for Neurasmus: the European Master in Neuroscience Universidade de Coimbra, Portugal
Universidade de Coimbra, Portugal
2021/09/15 - Current Coordinator of the Master Degree in Cellular and Molecular Biology Universidade de Coimbra, Portugal
Universidade de Coimbra, Portugal
2020/09/22 - Current Member of the Board of Directors Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Others

Category
Host institution
Employer
2018/02/01 - Current Group Leader Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Projects

Grant

Designation Funders
2022 - Current SHANKAstro: Astrocytes dysfunctions in Phelan-McDermid syndrome: from mechanisms towards new therapeutic strategies
NEURON/0002/2021
Principal investigator
Universidade de Coimbra, Portugal
European Commission
2022 - Current BrainCils: Neuronal primary cilia and chromatin dysregulation - Exploring the missing link in neurodevelopmental disorders using brain organoids
EXPL/MED-OUT/1470/2021
Researcher
Universidade de Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
2021 - Current Postnatal Reorganization of the cerebellum via Neuron-microglia interaction: IL-4 as a mediator between ADHD and allergies
PTDC/MED-NEU/5993/2020
Principal investigator
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
2021 - Current The social code in cingulate-hippocampal circuits
#074/2020
Principal investigator
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação Bial
2020 - Current IBRO Early Carrer Award - Deficits in mGluR activity in GPRASP2 mutant mice
ECA
Principal investigator
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
International Brain Research Organization
2020 - Current A Saúde no Saber
45-2019/478
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Ciência Viva
2021 - 2022 NeuroCompute: Exploring the missing link between neuronal primary cilia dysfunction and neurophysiological properties using brain organoids and computational modelling
NeuroCompute
Researcher
Universidade de Coimbra, Portugal
Universidade de Coimbra
2019 - 2022 Syn2Psy - Synaptic Dysfunction in Neuropsychiatric Disorders
H2020-MSCA-ITN-2018-813986
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
EU Framework Programme for Research and Innovation Marie Sklodowska-Curie Actions
2018 - 2021/09/30 Alternate SNAPs in neurotransmitter release: from molecular function to neurocognitive dysfunction
PTDC/BIA-CEL/29451/2017
Researcher
Fundação para a Ciência e a Tecnologia
2018 - 2021/06/30 Cognitive disorders as defects in synaptic function: insight from human mutations in the CACNG2 gene
PTDC/MED-NEU/28541/2017
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
2018 - 2021/06 BrainEdition: remotely controlling gene edition in neural stem cells
PTDC/NAN-MAT/28060/2017
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
2018 - 2020 ProTeAN - Production and Testing of humAn-derived Neurons and brain organoids: advanced model probing in neurodevelopmental disorders
MSCA-IF-EF-RI-799164
Supervisor
European Commission
2017 - 2020 BrainHealth2020: Early Detection, Neuromodulation and Advanced Therapies to Brain Disorders
CENTRO-01-0145-FEDER-000008
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
CENTRO2020

FEDER - Fundo Europeu de Desenvolvimento Regional
2018 - 2019/09 Exploring striatal postsynaptic SAPAP3 in Huntington’s disease
Grant Number: 948
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
EHDN-European Huntington’s Disease Network
2017 - 2019 Early life stress and social hierarchies: the role of cortico-striatal circuits
216/16
Principal investigator
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação Bial
2017 - 2019 The influence of maternal bonding in neuroimmune synaptic sculpting
264/2016
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação Bial
2016 - 2019 Social hierarchy and early life adversity: optogenetic modulation of prefrontal cortical circuits and neuroepigenetic regulation
PTDC/NEU-SCC/3247/2014
Principal investigator
Secretaria de Estado de Ciência Tecnologia e Ensino Superior
2014 - 2017 NARSAD Young Investigator Grant
20733
Principal investigator
Brain and Behavior Research Foundation
2013 - 2017 CELLSYNCIRCUITS: Cellular and synaptic dissection of the neuronal circuits of social and autistic behavior
PCIG13-GA-2013-618525
Principal investigator
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
EU Framework Programme for Research and Innovation Marie Sklodowska-Curie Actions
2011 - 2012 Autism Speaks Translational Fellow: Neural circuits of social behavior
7649
Principal investigator
Massachusetts Institute of Technology, United States

Contract

Designation Funders
2021 - Current Does healthy microglia rescue neuroinflammation and synaptic dysfunction in human cerebral organoids with FTD-associated mutations?
2020_119
Principal investigator
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Takeda Pharmaceutical Company Limited

Other

Designation Funders
2019 - Current Pfizer Award 2019 in Basic Research
2019 / Basic Research
Principal investigator
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Pfizer Portugal
2013 - 2018 FCT Investigator Award
IF/00812/2012/CP0151/CT0001
Principal investigator
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2016 - 2017 AidToC - Ab initio designed Tools for optogenetic Control of retinal circuits
141733
Supervisor
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação Calouste Gulbenkian
2013 - 2014/12/31 PROJECTO ESTRATÉGICO - LA 1 - 2013-2014 PEst-C/SAU/LA0001/2013
Pest-C/SAU/LA0001/2013-2014
Researcher
CNC.IBILI, Portugal
Fundação para a Ciência e a Tecnologia
Outputs

Publications

Book chapter
  1. Rodrigues, Artur Filipe; Rebelo, Catarina; Reis, Tiago; Sousa, João André; Pinho, Sónia L. C.; Sargento-Freitas, João; Peça, João; Ferreira, Lino. "Therapeutic Approaches for Stroke: A Biomaterials Perspective". In Engineering Biomaterials for Neural Applications, 185-218. Springer International Publishing, 2021.
    10.1007/978-3-030-81400-7_8
  2. Peça, João. "The Social Brain". In Cérebro – mais vasto que o céu. Lisboa: Fundação Calouste Gulbenkian, 2019.
    Published
  3. Caldeira, Gladys; Carvalho, Ana Luísa; Peça, João. "Schizophrenia". In Neurociências, edited by Duarte, Carlos; Rego, Cristina. Portugal: Lidel, 2017.
    Published
  4. Fernandes, Joana; Franco, Lara; Peça, João. "Autism Spectrum Disorders". In Neurociências, edited by Duarte, Carlos; Rego, Cristina; Oliveira, Catarina. Portugal: Lidel, 2017.
    Published
  5. Heyer, M.P.; Feliciano, C.; Peca, J.; Feng, G.. "Elucidating Gene Function through use of Genetically Engineered Mice". In Genomics. Wiley Online Books, 2010.
    10.1002/9780470711675.ch10
Conference paper
  1. Costa, Jéssica; Guedes, Joana; Franco, Lara; Peça, João; Cardoso, Ana Luísa. "Microglia morphology and density analysis: using stereology and 3D reconstruction to study the neuroimmune impact of early life stress". Paper presented in Paper presented in 52th International Congress on Microscopy and Microanalysis, Coimbra, 2018.
  2. Viegas, Ana Teresa; Carmona, Vítor; Almeida, Luis; Oliveira, Catarina Resende; Magalhães, João; Peça, João; Cardoso, Ana Luísa. "MicroRNA contribution in a new therapeutic strategy for Alzheimer’s disease". Paper presented in The 2016 Alzheimer’s Disease Congress, London, 2016.
Journal article
  1. Caldeira, Gladys Lima; Inácio, Ângela; Beltrão, Nuno; Barreto, Carlos A. V.; Ventura Rodrigues, Marina; Rondão, Tiago; Macedo, Renato; et al. "Aberrant hippocampal transmission and behavior in mice with a stargazin mutation linked to intellectual disability". Molecular Psychiatry (2022): https://www.nature.com/articles/s41380-022-01487-w.
    Published
  2. Jéssica Costa; Solange Martins; Pedro A. Ferreira; Ana M.S. Cardoso; Joana R. Guedes; João Peça; Ana L. Cardoso. "The old guard: Age-related changes in microglia and their consequences". Mechanisms of Ageing and Development 197 (2021): 111512-111512. https://doi.org/10.1016/j.mad.2021.111512.
    10.1016/j.mad.2021.111512
  3. Sequeira, Diana B.; Oliveira, Ana Rafaela; Seabra, Catarina M.; Palma, Paulo J.; Ramos, Carlos; Figueiredo, Maria H.; Santos, Ana C.; et al. "Regeneration of pulp-dentin complex using human stem cells of the apical papilla: in vivo interaction with two bioactive materials". Clinical Oral Investigations (2021): http://dx.doi.org/10.1007/s00784-021-03840-9.
    10.1007/s00784-021-03840-9
  4. Ribeiro, Luís F.; Catarino, Tatiana; Carvalho, Mário; Cortes, Luísa; Santos, Sandra D.; Opazo, Patricio O.; Ribeiro, Lyn Rosenbrier; et al. "Ligand-independent activity of the ghrelin receptor modulates AMPA receptor trafficking and supports memory formation". Science Signaling 14 670 (2021): eabb1953. http://dx.doi.org/10.1126/scisignal.abb1953.
    10.1126/scisignal.abb1953
  5. Lemos, Filipe; Prins, Caio; Carpi-Santos, Raul; Waclawiak, Ingrid; Sofia, Santos; Bernardes, Emerson; Peça, João; et al. "Galectin-3 in the Gut-liver axis Regulates Autistic-like Behaviors by Mechanism Associated with Cerebral Shank-3+ cell Niches in BALB/c Mice". Preprint (2021):
    Submitted
  6. Li, Yinqing; Lopez-Huerta, Violeta G.; Adiconis, Xian; Levandowski, Kirsten; Choi, Soonwook; Simmons, Sean K.; Arias-Garcia, Mario A.; et al. "Distinct subnetworks of the thalamic reticular nucleus". Nature 583 7818 (2020): 819-824. http://dx.doi.org/10.1038/s41586-020-2504-5.
    10.1038/s41586-020-2504-5
  7. Franco, Lara O.; Carvalho, Mário J.; Costa, Jéssica; Ferreira, Pedro A.; Guedes, Joana R.; Sousa, Renato; Edfawy, Mohamed; et al. "Social subordination induced by early life adversity rewires inhibitory control of the prefrontal cortex via enhanced Npy1r signaling". Neuropsychopharmacology 45 9 (2020): 1438-1447. http://dx.doi.org/10.1038/s41386-020-0727-7.
    Open access • 10.1038/s41386-020-0727-7
  8. Barros-Viegas, Ana Teresa; Carmona, Vítor; Ferreiro, Elisabete; Guedes, Joana; Cardoso, Ana Maria; Cunha, Pedro; Pereira de Almeida, Luís; et al. "miRNA-31 Improves Cognition and Abolishes Amyloid-ß Pathology by Targeting APP and BACE1 in an Animal Model of Alzheimer’s Disease". Molecular Therapy - Nucleic Acids 19 (2020): 1219-1236. http://dx.doi.org/10.1016/j.omtn.2020.01.010.
    Open access • 10.1016/j.omtn.2020.01.010
  9. Lima Caldeira, Gladys; Peça, João; Carvalho, Ana Luísa. "New insights on synaptic dysfunction in neuropsychiatric disorders". Current Opinion in Neurobiology 57 (2019): 62-70. http://dx.doi.org/10.1016/j.conb.2019.01.004.
    10.1016/j.conb.2019.01.004
  10. Edfawy, Mohamed; Guedes, Joana R.; Pereira, Marta I.; Laranjo, Mariana; Carvalho, Mário J.; Gao, Xian; Ferreira, Pedro A.; et al. "Abnormal mGluR-mediated synaptic plasticity and autism-like behaviours in Gprasp2 mutant mice". Nature Communications 10 1 (2019): http://dx.doi.org/10.1038/s41467-019-09382-9.
    10.1038/s41467-019-09382-9
  11. Sequeira, Diana; Seabra, Catarina; Palma, Paulo; Cardoso, Ana; Peça, João; Santos, João. "Effects of a New Bioceramic Material on Human Apical Papilla Cells". Journal of Functional Biomaterials 9 4 (2018): 74. http://dx.doi.org/10.3390/jfb9040074.
    10.3390/jfb9040074
  12. Santos, Tiago; Ferreira, Raquel; Quartin, Emanuel; Boto, Carlos; Saraiva, Cláudia; Bragança, José; Peça, João; et al. "Blue light potentiates neurogenesis induced by retinoic acid-loaded responsive nanoparticles". Acta Biomaterialia 59 (2017): 293-302. http://dx.doi.org/10.1016/j.actbio.2017.06.044.
    Published • 10.1016/j.actbio.2017.06.044
  13. Ting, Jonathan T.*; Peça, João*; Feng, Guoping. "Functional Consequences of Mutations in Postsynaptic Scaffolding Proteins and Relevance to Psychiatric Disorders". Annual Review of Neuroscience 35 1 (2012): 49-71. http://dx.doi.org/10.1146/annurev-neuro-062111-150442.
    10.1146/annurev-neuro-062111-150442
  14. Peça, J.; Feng, G.. "Cellular and synaptic network defects in autism". Current Opinion in Neurobiology 22 5 (2012): 866-872. http://www.scopus.com/inward/record.url?eid=2-s2.0-84867426528&partnerID=MN8TOARS.
    10.1016/j.conb.2012.02.015
  15. Peça, J.; Ting, J.; Feng, G.. "SnapShot: Autism and the synapse". Cell 147 3 (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-84855174133&partnerID=MN8TOARS.
    10.1016/j.cell.2011.10.015
  16. Peça, J.; Feng, G.. "Neuroscience: When lights take the circuits out". Nature 477 7363 (2011): 165-166. http://www.scopus.com/inward/record.url?eid=2-s2.0-80052602669&partnerID=MN8TOARS.
    10.1038/477165a
  17. Peça, J.; Feliciano, C.; Ting, J.T.; Wang, W.; Wells, M.F.; Venkatraman, T.N.; Lascola, C.D.; Fu, Z.; Feng, G.. "Shank3 mutant mice display autistic-like behaviours and striatal dysfunction". Nature 472 7344 (2011): 437-442. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955536349&partnerID=MN8TOARS.
    10.1038/nature09965
  18. Arenkiel, Benjamin R.; Peça, João. "Using Light to Reinstate Respiratory Plasticity". Journal of Neurophysiology 101 4 (2009): 1695-1698. http://dx.doi.org/10.1152/jn.00009.2009.
    Open access • 10.1152/jn.00009.2009
  19. Welch, Jeffrey M.; Lu, Jing; Rodriguiz, Ramona M.; Trotta, Nicholas C.; Peca, Joao; Ding, Jin-Dong; Feliciano, Catia; et al. "Cortico-striatal synaptic defects and OCD-like behaviours in Sapap3-mutant mice". Nature 448 7156 (2007): 894-900. http://dx.doi.org/10.1038/nature06104.
    10.1038/nature06104
  20. Wang, H.*; Peca, J.*; Matsuzaki, M.*; Matsuzaki, K.; Noguchi, J.; Qiu, L.; Wang, D.; et al. "High-speed mapping of synaptic connectivity using photostimulation in Channelrhodopsin-2 transgenic mice". Proceedings of the National Academy of Sciences 104 19 (2007): 8143-8148. http://dx.doi.org/10.1073/pnas.0700384104.
    Open access • 10.1073/pnas.0700384104
  21. Arenkiel, Benjamin R.; Peca, Joao; Davison, Ian G.; Feliciano, Catia; Deisseroth, Karl; Augustine, George J.; Ehlers, Michael D.; Feng, Guoping. "In Vivo Light-Induced Activation of Neural Circuitry in Transgenic Mice Expressing Channelrhodopsin-2". Neuron 54 2 (2007): 205-218. http://dx.doi.org/10.1016/j.neuron.2007.03.005.
    Open access • Published • 10.1016/j.neuron.2007.03.005
Journal issue
  1. Xu, Junyu; Shi, Lei; Peça, João. "Autism Spectrum Disorder: New Insights Into Molecular Pathophysiology and Therapeutic Development". Frontiers in Cellular Neuroscience (2020):
    Published
Thesis / Dissertation
  1. Peça, João. "Genetic and optogenetic engineering as a strategy to probe neuronal circuits". PhD, 2011.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2021/05/07 Reprogramming and stem cells in neurodevelopmental disorders X Seminário da Sociedade de Pediatria do Neurodesenvolvimento
(online)
2019/10/12 Cerebral organoids as research tools for neurodevelopmental disorders Grupo de Estudos de Envelhecimento Cerebral e Demência
Grupo de Estudos de Envelhecimento Cerebral e Demência (Curia)
2019 Abnormal mGlur-mediated synaptic plasticity and autism-like behaviours in Gprasp2 mutant mice Spring Meeting of the International Graduate School in Molecular Medicine Ulm University
Ulm University (Ulm, Germany)
2019 Metabotropic glutamate receptors as a common dysfunction in neurodevelopmental disorders Invited Seminar
University of Edinburgh (Edinburgh, United Kingdom)
2019 Rain Man - Discussão sobre um filme que incide sobre autismo e Síndrome Savant "Cérebro mais vasto que o céu" - The brain at the movies -
Gulbenkian Foundation (Lisbon, Portugal)
2018 mGluR signaling in Autism Spectrum Disorders ECMED Summer School– Extracellular Matrix in Epileptogenesis
ECMED ITN (Warsaw, Poland)
2017 Genetic dissection of Neuronal Circuits in autism spectrum disorders In4Med Congress
Medical Student Association - Faculty of Medicine, University of Coimbra (Coimbra, Portugal)
2016 Disruption of the mGLuR signaling network - a molecular focal point for ASDs Neurodevelopmental Disorders: from neuroscience to the clinic
Champalimaud Foundation & PIN (Progresso Infantil) (Lisbon, Portugal)
2016 Disruption of the mGluR signaling network - A molecular focal point for ASDs - II Simpósio de pós-graduação em Biomedicina
Universidade de Aveiro (Aveiro, Portugal)
2016 GPCR associated proteins - GPRASPing mGluR signalling dysfunction in autism spectrum disorders Society of Neuroscience: Nanosymposium on Molecular and Cellular Mechanisms in Autism Models and other Developmental Diseases
Society of Neuroscience (San Diego, United States)
2014 Neuronal and Gene Networks Regulating Social Behavior XVIII Congress of the Portuguese Society for Biochemistry
Portuguese Society for Biochemistry (Coimbra, Portugal)
2011 Genetic and optogenetic engineering to manipulate and probe neuronal circuits and behavior IX Encontro Anual do CNC
Centro de Neurociências e Biologia Celular (Coimbra, Portugal)
2011 Shank synaptic genes in autism: Human genetics to mouse models and therapeutics IMFAR - 2011 International Meeting for Autism Research
(San Diego, United States)

Supervision

Thesis Title
Role
Degree Subject (Type)
Institution / Organization
2019 - 2020 Impact of early-life stress on microglia: Neuron dynamics in the medial prefrontal cortex
Co-supervisor of Solange Martins Nogueira
Biologia Celular e Molecular (Master) (Master)
Universidade de Coimbra, Portugal
2018 - 2019 Microglia-mediated remodelling of the cerebellar circuit
Supervisor of Pedro António Cruz Ferreira
Biologia Celular e Molecular (Master)
Universidade de Coimbra, Portugal
2017 - 2018 Optogenetic modulation of corticoestriatal activity for the regulation of social dominance
Supervisor of José Pedro Pinto Sampaio
Biologia Celular e Molecular (Master)
Universidade de Coimbra, Portugal
2017 - 2018 The role of GPRASP2 on mGluR5 signalling
Supervisor of Mariana Barradas Serrano Laranjo
Biologia Celular e Molecular (Master)
Universidade de Coimbra, Portugal
2014 - 2018 Long-term impact of early life stress on adult social behavior and prefrontal cortical circuits
Supervisor of Lara Oliveira Franco
Biologia Experimental e Biomedicina (PhD)
Universidade de Coimbra, Portugal
2016 - 2017 Characterization of Gprasp2 knockout mice as a new model for autism spectrum disorders
Supervisor of Marta Isabel Ferreira Leite Pereira
Biologia Celular e Molecular (Master)
Universidade de Coimbra, Portugal
2016 - 2017 The role of cortico-striatal circuits in social hierarchies
Supervisor of Tiago João Dos Santos Reis
Biologia Celular e Molecular (Master)
Universidade de Coimbra, Portugal
2013 - 2017 Dissecting the role of GPRASP2 in autism spectrum disorder and intellectual disability
Supervisor of Mohamed Edfawy Soliman Hussien
Biologia Experimental e Biomedicina (PhD)
Universidade de Coimbra, Portugal
2013 - 2017 The role of stargazin in the pathogenesis of psychiatric disorders
Co-supervisor of Gladys Tarcila Lima Caldeira
Biologia Experimental e Biomedicina (PhD)
Universidade de Coimbra, Portugal
2015 - 2016 Dissection of hierarchy formation in mice: behavioral and molecular correlates of dominance
Supervisor of Renato José Melo Sousa
Biologia Celular e Molecular (Master)
Universidade de Coimbra, Portugal
2014 - 2015 Optogenetics and biotechnology : production and in vitro characterization of Ab-Initio designed channelrhodopsin-2 mutants
Supervisor
Biotecnologia Farmacêutica (Master)
Universidade de Coimbra, Portugal
2013 - 2014 Intelligent design of color-tuned ChR2 variants for optogenetics applications
Supervisor of Bruno Cruz
Biologia Celular e Molecular (Master)
Universidade de Coimbra, Portugal
2013 - 2014 Molecular mechanisms of the synaptic and cognitive effects of ghrelin
Supervisor of Mário Jorge Da Silva Carvalho
Biologia Celular e Molecular (Master)
Universidade de Coimbra, Portugal
2013 - 2014 Expression and purification of Channelrhodopsin-2 in Pichia pastoris: generation of blue-shifted and redshifted optogenetic variants
Supervisor of Fabio Mazza
Biologia Celular e Molecular (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Event organisation

Event name
Type of event (Role)
Institution / Organization
2014 - Current Neuronal Circuits and Behavior: Advanced course (2014)
Workshop (President of the Organising Committee)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2020 - 2021 XVI Meeting of the Portuguese Society for Neuroscience (2020 - 2021)
Meeting (Member of the Organising Committee)
Sociedade Portuguesa de Neurociências, Portugal
2016/07 - 2016/07 7th ISN Special Neurochemistry Conference (2016/07 - 2016/07)
Conference (Co-organisor)
International Society for Neurochemistry, Switzerland

Event participation

Activity description
Type of event
Event name
Institution / Organization
2021/10/15 - 2021/10/15 Round table participation in "FIC.A". A portuguese initiative to promote science and education.
Round table
Neurociência³ - Três formas de estudar o cérebro
Festival Internacional de Ciência, FICA, Portugal

Jury of academic degree

Topic
Role
Candidate name (Type of degree)
Institution / Organization
2022/03/18 A comprehensive characterization of cerebellar pathology in an animal model of Spinocerebellar Ataxia Type 3
(Thesis) Main arguer
Ana Catarina Coutinho Vilaça Ferreira (Master)
Universidade do Minho, Portugal
2021/12/14 Optogenetic activation of intracelular adenosine A2A receptor signaling in the amygdala as a model of stress in rodents
(Thesis) Main arguer
Catarina Bernardino Carreira (Master)
Universidade de Coimbra, Portugal
2021/11/23 Phenotypic architecture and genetic polymorphisms associated with social behaviour in Zebrafish
(Thesis) Main arguer
Cláudia Gonçalves (PhD)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2021/11/22 Unravelling the activity patterns of midbrain dopaminergic neurons during male sexual behaviour
(Thesis) Main arguer
Silvana da Costa Araújo (PhD)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2021/11/19 NMR metabonomics applied to synaptosomes and slices to profile metabolic alterations in neurodegenerative and neuroprotective mechanisms
(Thesis) Arguer
Andreia Filipa Simões Oliveira (Master)
Universidade de Coimbra, Portugal
2021/04/28 Striatal plasticity upon learning of a lateralized motor task
(Thesis) Main arguer
Ana Margarida Pinto (Master)
Universidade Nova de Lisboa, Portugal
2021/02/26 Cell-type specific neuronal manipulation of cortex and striatum during action selection
(Thesis) Main arguer
Rodrigo Ferreira Mantins (Master)
2020/12/17 Cell-type specificity of cortico-cortical connections between the visual and retrosplenial cortices of the mouse
(Thesis) Arguer
Ana Beatriz Simões Sá e Moura (Master)
Universidade de Coimbra, Portugal
2020/12/14 Revealing the role of neocortical circuit defects in cognitive alterations in autism spectrum disorder
(Thesis) Main arguer
Maria José Gueidão Costa (Master)
Universidade de Coimbra, Portugal
2020/11/02 Analysis of the hippocampal and cortex proteome of mice exposed to psychotropic medication
(Thesis) Arguer
Cátia João Monteiro da Santa (PhD)
Universidade de Coimbra, Portugal
2020/07/07 Oxytocinergic modulation of social information use in threat perception
(Thesis) Main arguer
Ibukun Dorcas Fatunke Akinrinade (PhD)
Universidade Nova de Lisboa, Portugal
2020/07/02 Cortico-hippocampal interactions as a neural substrate for the retrieval of contextual memories in choice behavior
(Thesis) Arguer
Emanuel Ferreira Fernandes (PhD)
Universidade Nova de Lisboa, Portugal
2020/06/29 Impact of human iPSC-derived NESC transplantation in MJD-associated neuropathology and motor impairments
(Thesis) Main arguer
Ana Catarina Paulino do Ó Vinhas (Master)
Universidade de Coimbra, Portugal
2020/06/19 Role of TET3 enzyme in brain function
(Thesis) Main arguer
Cláudia Antunes (PhD)
Universidade do Minho, Portugal
2020/01/13 The Computational Roles of Dopamine and Serotonin in Tourette Syndrome and Obsessive-Compulsive Disorder
Thesis Member
Vasco Manuel Aranha da Conceição (PhD)
Universidade de Lisboa, Portugal
2019 Mate choice and social preference in Mus musculus females
(Thesis) Main arguer
Luís Fernando Gomes Moreira (PhD)
Universidade Nova de Lisboa, Portugal
2019 Mechanisms of Self-Defense Suppression of Mothers Under Threat in the Presence of Offspring
(Thesis) Main arguer
Elizabeth Maria Rickenbacher (PhD)
Universidade Nova de Lisboa, Portugal
2019 The Computational Roles of Dopamine and Serotonin in Tourette Syndrome and Obsessive-Compulsive Disorder
(Thesis) Arguer
Vasco Manuel Aranha da Conceição (PhD)
Universidade de Lisboa Faculdade de Medicina, Portugal
2019 Investigating potential treatment strategies and underlying mechanisms in the Fragile X Syndrome mouse and rat models
(Thesis) Main arguer
Melania Muscas (PhD)
The University of Edinburgh, United Kingdom
2019 Neurobehavioural and molecular mechanisms of social learning in zebrafish
(Thesis) Main arguer
Júlia Sabrina Ferreira Pinho (PhD)
Instituto Universitário de Ciências Psicológicas Sociais e da Vida, Portugal
2019 Targeting adenosine A2A receptors to manage Angelman syndrome symptoms
(Thesis) Main arguer
Ana Teresa Capitão Moreira de Sá (Master)
Universidade de Coimbra, Portugal
2019 Investigating the structural and physiological properties of ventromedial hypothalamic neurons across the estrous cycle of female mice
(Thesis) Main arguer
Ines Correia Dias (Master)
Universidade de Coimbra, Portugal
2018/12/20 Role of laterodorsal tegmentum in motivation and reward
(Thesis) Main arguer
Bárbara Guimarães Salazar Coimbra (PhD)
Universidade do Minho, Portugal
2018 Measuring dopamine release in different domains of the striatum during the development of habitual reward seeking.
(Thesis) Main arguer
João Manuel Silveira De Matos (Master)
Universidade de Coimbra, Portugal
2018 Mapping the neural circuitry underlying spatial and temporal locomotor adaptation
(Thesis) Main arguer
Marta Rocha Maciel (Master)
Universidade de Coimbra, Portugal
2017 The Role of the PgR+ cells of the Ventromedial Hypothalamus (VMHvl) in Female Mice Sexual Receptivity
(Thesis) Main arguer
Inês Mendes Preguiça (Master)
Universidade de Coimbra, Portugal
2017 Unravelling the circuits involved in ejaculation in mice (Mus musculus)
(Thesis) Main arguer
Ana Rita Pimentel Mendes (Master)
Universidade de Coimbra, Portugal
2016 Role of Nucleus accumbens dopamine D1- and D2-expressing neurons in reward and motivation
(Thesis) Main arguer
Carina Isabel Soares Da Cunha (PhD)
Universidade do Minho, Portugal
2016 Contribution of the ventro-lateral periaqueductal grey matter to fear conditioned analgesia
(Thesis) Main arguer
Nanci Aléxia Vieira Winke (Master)
Universidade de Coimbra, Portugal
2015 Contextualizing experience: plasticity pf cortical and subcortical systems for controlling auditory perception
(Thesis) Arguer
Ana Raquel Oliveira Martins (PhD)
Universidade de Coimbra, Portugal
2015 Neural and behavioral correlates of decision confidence.
(Thesis) Arguer
Gil Miguel Pereira da Costa (PhD)
Universidade de Coimbra, Portugal
2015 The role of serotonin in behavior: Shining light on the maestro of the brain
(Thesis) Arguer
Patrícia Correia (PhD)
Universidade Nova de Lisboa, Portugal
2015 Synaptic and circuitry mechanisms of basal ganglia dysfunction in compulsive and repetitive behavior
(Thesis) Arguer
Patrícia Isabel Rodrigues Monteiro (PhD)
Universidade de Coimbra, Portugal
2015 Estudo da potencial toxicidade do processo de silenciamento da ataxina 3 mutante humana mediado por shRNA lentiviral
(Thesis) Main arguer
José Miguel Antunes Codêsso (Master)
Universidade de Coimbra, Portugal
2015 GADD45ß : a novel long-term memory mediator
(Thesis) Main arguer
David Vilhena Catarino Brito (Master)
Universidade de Coimbra, Portugal
2015 Dissociating the role of interneurons in sensory processing
(Thesis) Main arguer
Inês Vitória Barreiros (Master)
Universidade de Coimbra, Portugal
2015 Circuit plasticity during up-states in mouse barrel cortex
(Thesis) Main arguer
Emanuel Oliveira (Master)
Universidade de Coimbra, Portugal
2014 Dimensions of compulsivity – on the relation between compulsive grooming, anxiety and cognitive flexibility, and the effect of deep brain stimulation
(Thesis) Main arguer
Cindy Maria De Oliveira Pinhal (Master)
Universidade de Coimbra, Portugal
2014 Prosocial choice in rats depends on rewards received and food-seeking behaviour displayed by recipients
(Thesis) Main arguer
Diana Paula Ferreira Da Costa (Master)
Universidade de Coimbra, Portugal
2013 Epileptogenesis and Therapeutic Options in a Tuberous Sclerosis Complex Epilepsy Mouse Model
(Thesis) Main arguer
Catia Alexandra Pinho Silva (Master)
Universidade de Coimbra, Portugal
2013 Mapping the Serotonergic System : Topographical Organization of Serotonergic Projections from the Dorsal Raphe Nucleus
(Thesis) Main arguer
Katherine Louise Turco (Master)
Universidade de Coimbra, Portugal

Association member

Society Organization name Role
2016 - Current Society for Neuroscience Member
2016 - Current International Society for Neurochemistry Member
2013 - Current Portuguese Society for Neuroscience Member

Conference scientific committee

Conference name Conference host
2019/05 - Current XVI Meeting of the Portuguese Society for Neuroscience
2021/03/10 - 2021/03/31 Brain Gain - Brain Awareness Week Center for Neuroscience and Cell Biology

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2020/11/12 - 2020/11/12 Advanced Imaging Methods in Neuroscience: Optogenetic labeling for monitoring and control of neuronal activity Optogenetic labeling for monitoring and control of neuronal activity (Doutoramento) Universidade de Coimbra, Portugal

Evaluation committee

Activity description
Role
Institution / Organization Funding entity
2013 - Current Ad Hoc reviewer for: Nature, Nature Neuroscience, Nature Medicine, Molecular Psychiatry, Neuron, Molecular Autism, PLOS One, Nature Communications, Journal of Pediatric Genomics, Journal of Neuroscience Methods, Frontiers in Cellular Neuroscience

Interview (tv / radio show)

Program Topic
2020/11 - 2020/11 A Saúde no Saber As vacinas causam autismo?
2019/12/11 - 2019/12/11 RTP 1 - Main Portuguese TV Channel - Outras Histórias - O Código do Autismo Autism
2019/12/04 - 2019/12/04 SIC Noticias - National TV News channel Autism
2014/11/13 - 2014/11/13 "Até os ratos são generosos" - TSF - Portuguese Radio Station Commentary on prosocial behavior
2008/09/12 - 2008/09/12 "Loucura Consciente" - TSF - Portuguese Radio Station Commentary on obsessive compulsive disorder reporting by TSF, Portugal

Journal scientific committee

Journal title (ISSN) Publisher
2020 - Current Frontiers in Behavioral Neuroscience Frontiers
2019 - Current Frontiers in Cellular Neuroscience (1662-5102) Frontiers Media SA

Mentoring / Tutoring

Topic Student name
2017 - Current Postdoctoral Fellow Joana Guedes
2017 - Current Postdoctoral Fellow Catarina Seabra

Other jury / evaluation

Activity description Institution / Organization
2019 - Current Grant Reviewer Agence nationale de la recherche, France
2019 - Current Evaluator for FCT Grants - Final progress report Fundação para a Ciência e a Tecnologia, Portugal
2018 - Current Grant Reviewer Graduate Women in Science, United States
Distinctions

Award

2022 2022 Teaching Innovation Award
Universidade de Coimbra, Portugal

Banco Santander Portugal, Portugal
2020 IBRO Early Career Award
International Brain Research Organization, France
2020 FENS-IBRO/PERC
Federation of European Neuroscience Societies, Belgium
2019 Prizer Prize
Pfizer Portugal, Portugal
2014 NARSAD Young Investigator Award
Brain and Behavior Research Foundation, United States

Title

2013 FCT Investigator
Fundação para a Ciência e a Tecnologia, Portugal
2011 Autism Speaks Translational Fellow
Autism Speaks, United States