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Noélia Duarte is graduated in Pharmaceutical Sciences (1995). ND received her MSc (1999) and PhD (2008) degrees in Pharmaceutical Chemistry (both from FFUL). She is an Assistant Professor at FFUL, and has expertise in several chromatographic and spectroscopic techniques (UV, FTIR, HPLC, GC, NMR and HPLC-MS). Teaching areas: Instrumental Methods of Analysis, Natural Products Chemistry and Structural Identification of Organic Compounds. Noélia Duarte is an effective member of the R&D Center Instituto de Investigação do Medicamento (iMed.ULisboa) and her research has been focus on the isolation and structural characterization of bioactive compounds from plants. In particular, N. Duarte has been interested in the identification of compounds with antitumoral and antimicrobial activities. In addition, she is also interested in Mass Spectrometry studies (LC-ESI-MS/MS) aiming the identification and quantification of various metabolites from plant extracts and biological samples. She participated in 4 national financed research projects. She is also supervisor and co-supervisor of Master thesis. She is author or co-author of 5 book chapters and 42 research papers in peer-reviewed scientific journals.
Identificação

Identificação pessoal

Nome completo
Noélia Maria Silva Dias Duarte

Nomes de citação

  • Duarte, Noélia

Identificadores de autor

Ciência ID
0F16-641D-A317
ORCID iD
0000-0003-3119-8745
Researcher Id
J-9254-2012
Scopus Author Id
15847567200

Endereços de correio eletrónico

  • mduarte@ff.ulisboa.pt (Profissional)

Telefones

Telefone
  • 217946400 Ext.: 14342 (Profissional)

Moradas

  • Faculty of Pharmacy, University of Lisbon. Avenida Prof. Gama Pinto, 1649-019, Lisboa, Lisboa, Portugal (Profissional)

Websites

  • http://www.ff.ul.pt/ (Profissional)

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês Utilizador independente (B2) Utilizador proficiente (C2) Utilizador proficiente (C1) Utilizador proficiente (C2)
Francês Utilizador elementar (A1) Utilizador independente (B1) Utilizador independente (B1) Utilizador elementar (A1)
Espanhol; Castelhano Utilizador elementar (A1) Utilizador proficiente (C1) Utilizador elementar (A1) Utilizador elementar (A1)
Formação
Grau Classificação
2008/06/11
Concluído
Farmácia (Doutoramento)
Especialização em Especialidade: Química Farmacêutica
Universidade de Lisboa, Portugal
"Structural Characterization and Biological Activities of Terpenic and Phenolic Compounds Isolated from Euphorbia Lagascae and Euphorbia Tuckeyana" (TESE/DISSERTAÇÃO)
Aprovada com Distinção e Louvor
1999
Concluído
Mestrado em Química Farmacêutica (Mestrado)
Universidade de Lisboa Faculdade de Farmácia, Portugal
"Contribuição para o estudo do pó de cortiça e da cortiça - extracção de proantocianidinas" (TESE/DISSERTAÇÃO)
Muito Bom
1995
Concluído
Ciências Farmacêuticas (Licenciatura)
Universidade de Lisboa Faculdade de Farmácia, Portugal
"n/a" (TESE/DISSERTAÇÃO)
16 valores
Percurso profissional

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento
Empregador
2008/06/12 - Atual Professor Auxiliar (Docente Universitário) Universidade de Lisboa, Portugal
1999 - 2008 Assistente (Docente Universitário) Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal

Outros

Categoria Profissional
Instituição de acolhimento
Empregador
1999/01/01 - 2000/01/21 Trainee Assistant of Analitical Chemistry Universidade de Lisboa Faculdade de Farmácia, Portugal
1996/01/01 - 1998/01/01 Master Student - Master Grant (BM/6523/95), JNICT Universidade de Lisboa Faculdade de Farmácia, Portugal
1993/09/01 - 1994/09/01 Young Investigator Grant (BJI 1454), JNICT Universidade de Lisboa Faculdade de Farmácia, Portugal
Projetos

Projeto

Designação Financiadores
2017 - Atual New Psychoactive Substances - A Platform for Risk Assessment of Teens Brain
PTDC/SAU-TOX/32515/2017
Investigador
Fundação para a Ciência e a Tecnologia
2017 - Atual Tackling multidrug resistance in cancer: plant-derived lead compounds as P-Glycoprotein (P-gp) and breast cancer resistant protein (BCRP) modulators and colateral sensitivity agents
PTDC/MED-QUIM/30591/2017
Investigador
2013 - 2015/06 Optimization of P-glycoprotein modulators and insights into the efflux mechanism
Provided by PTCRIS: 125629
125629
Investigador
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
Fundação para a Ciência e a Tecnologia
2010 - 2014/03 Diterpenes as lead compounds for overcoming multidrug resistance in cancer cells: P-glycoprotein modulators and antiproliferative agents
99815
Provided by PTCRIS: 99815
Investigador
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
Fundação para a Ciência e a Tecnologia
Produções

Publicações

Artigo em conferência
  1. Maria José U. Ferreira; Duarte, Noélia. "Searching for natural antituberculars from mozambican medicinal plants". Trabalho apresentado em Saber Tropical em Moçambique: História, Memória e Ciência, Lisboa, 2013.
Artigo em revista
  1. Mendes, Eduarda; Duarte, Noélia; Eduarda Mendes; Noélia Duarte. "Mid-Infrared Spectroscopy as a Valuable Tool to Tackle Food Analysis: A Literature Review on Coffee, Dairies, Honey, Olive Oil and Wine". Foods 10 2 (2021): 477-477. http://dx.doi.org/10.3390/foods10020477.
    Acesso aberto • Publicado • 10.3390/foods10020477
  2. Ana Henriques Mota; Noélia Duarte; Ana Teresa Serra; António Ferreira; Maria Rosário Bronze; Luísa Custódio; Maria Manuela Gaspar; et al. "Further Evidence of Possible Therapeutic Uses of Sambucus nigra L. Extracts by the Assessment of the In Vitro and In Vivo Anti-Inflammatory Properties of Its PLGA and PCL-Based Nanoformulations". Pharmaceutics 12 12 (2020): 1181-1181. https://doi.org/10.3390/pharmaceutics12121181.
    10.3390/pharmaceutics12121181
  3. Garcia, Catarina; Isca, Vera M. S.; Pereira, Filipe; Monteiro, Carlos M.; Ntungwe, Epole; Sousa, Francisco; Dinic, Jelena; et al. "Royleanone Derivatives From Plectranthus spp. as a Novel Class of P-Glycoprotein Inhibitors". Frontiers in Pharmacology 11 557789 (2020): http://dx.doi.org/10.3389/fphar.2020.557789.
    Acesso aberto • Publicado • 10.3389/fphar.2020.557789
  4. Andreia Bento-Silva; Noélia Duarte; Elsa Mecha; Maria Belo; Maria Carlota Vaz Patto; Maria do Rosário Bronze. "Hydroxycinnamic Acids and Their Derivatives in Broa, a Traditional Ethnic Maize Bread". Foods 9 10 (2020): 1471-1471. https://doi.org/10.3390/foods9101471.
    10.3390/foods9101471
  5. Mota, Ana Henriques; Andrade, Joana M.; Rodrigues, Maria João; Custódio, Luísa; Bronze, Maria Rosário; Duarte, Noélia; Baby, André; et al. "Synchronous insight of in vitro and in vivo biological activities of Sambucus nigra L. extracts for industrial uses". Industrial Crops and Products 154 (2020): 112709. http://dx.doi.org/10.1016/j.indcrop.2020.112709.
    10.1016/j.indcrop.2020.112709
  6. Vera M. S. Isca; Joana Andrade; Ana Sofia Fernandes; Paulo Paixão; Clara Uriel; Ana María Gómez; Noélia Duarte; Patrícia Rijo. "In Vitro Antimicrobial Activity of Isopimarane-Type Diterpenoids". Molecules (2020): https://doi.org/10.3390/molecules25184250.
    10.3390/molecules25184250
  7. Adeoye, Oluwatomide; Bártolo, Inês; Conceição, Jaime; da Silva, Andreia Bento; Duarte, Noélia; Paula Francisco, Ana; Taveira, Nuno; Cabral-Marques, Helena. "Pyromellitic dianhydride crosslinked soluble cyclodextrin polymers: Synthesis, lopinavir release from sub-micron sized particles and anti-HIV-1 activity". International Journal of Pharmaceutics (2020): 119356. http://dx.doi.org/10.1016/j.ijpharm.2020.119356.
    10.1016/j.ijpharm.2020.119356
  8. Faustino, C.; Martins, T.; Duarte, N.; Ribeiro, M.H.. "Self-Assembly of Lipoaminoacids-DNA Based on Thermodynamic and Aggregation Properties". Journal of Surfactants and Detergents (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85078655818&partnerID=MN8TOARS.
    10.1002/jsde.12391
  9. Adeoye, O.; Conceição, J.; Serra, P.A.; Bento da Silva, A.; Duarte, N.; Guedes, R.C.; Corvo, M.C.; et al. "Cyclodextrin solubilization and complexation of antiretroviral drug lopinavir: In silico prediction; Effects of derivatization, molar ratio and preparation method". Carbohydrate Polymers 227 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85072659617&partnerID=MN8TOARS.
    10.1016/j.carbpol.2019.115287
  10. Ana Marta Matos; Reis, Mariana Alves; Duarte, Noélia; Ricardo Ferreira; Ferreira, Maria-Jose U.. "Epoxylathyrane derivatives as MDR-selective compounds for disabling multidrug resistance in cancer". Frontiers in Pharmacology 11 (2020): 519.
    Acesso aberto • Publicado • 10.3389/fphar.2020.00599
  11. Carrola, J.; Duarte, N.; Florindo, P.; Henriques, S.; da Silva, G.; Bijlsma, L.; Moreira, R.; et al. "Metabolism of N-ethylhexedrone and buphedrone: An in vivo study in mice using HPLC-MS/MS". Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences 1159 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85090272900&partnerID=MN8TOARS.
    10.1016/j.jchromb.2020.122340
  12. Catarina Garcia; Epole Ntungwe; Ana Rebelo; Bessa, C.; Tijana Stankovic; Jelena Dinic; Díaz Lanza Ana M.; et al. "Parvifloron D from Plectranthus strigosus: Cytotoxicity Screening of Plectranthus spp. Extracts". Biomolecules (2019): https://www.mdpi.com/2218-273X/9/10/616.
    10.3390/biom9100616
  13. Faustino, Celia; Francisco, Ana Paula; Isca, Vera M. S.; Duarte, Noelia. "Cytotoxic Stilbenes and Derivatives as Promising Antimitotic Leads for Cancer Therapy". Current pharmaceutical design (2019): http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=MEDLINE&KeyUT=MEDLINE:30636588&KeyUID=MEDLINE:30636588.
    10.2174/1381612825666190111123959
  14. Garcia, Catarina; Teodosio, Catarina; Oliveira, Carolina; Oliveira, Claudia; Diaz-Lanza, Ana; Reis, Catarina; Duarte, Noelia; Rijo, Patricia. "Naturally occurring Plectranthus-derived diterpenes with antitumoral activities". Current pharmaceutical design (2019): http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=MEDLINE&KeyUT=MEDLINE:30644340&KeyUID=MEDLINE:30644340.
    10.2174/1381612825666190115144241
  15. Neto, S.; Duarte, N.; Pedro, C.; Spengler, G.; Molnár, J.; Ferreira, M.-J.U.. "Effective MDR reversers through phytochemical study of Euphorbia boetica". Phytochemical Analysis 30 5 (2019): 498-511. http://www.scopus.com/inward/record.url?eid=2-s2.0-85067440956&partnerID=MN8TOARS.
    10.1002/pca.2841
  16. Roque, Luis; Duarte, Noelia; Bronze, Maria Rosario; Garcia, Catarina; Alopaeus, Julia; Molpeceres, Jesus; Hagesaether, Ellen; et al. "Development of a bioadhesive nanoformulation with Glycyrrhiza glabra L. extract against Candida albicans". Biofouling (2018): 1-13. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=MEDLINE&KeyUT=MEDLINE:30362371&KeyUID=MEDLINE:30362371.
    10.1080/08927014.2018.1514391
  17. Mónico, A.; Nim, S.; Duarte, N.; Rawal, M.K.; Prasad, R.; Di Pietro, A.; Ferreira, M.-J.U.. "Lathyrol and epoxylathyrol derivatives: Modulation of Cdr1p and Mdr1p drug-efflux transporters of Candida albicans in Saccharomyces cerevisiae model". Bioorganic and Medicinal Chemistry 25 13 (2017): 3278-3284. http://www.scopus.com/inward/record.url?eid=2-s2.0-85018347859&partnerID=MN8TOARS.
    10.1016/j.bmc.2017.04.016
  18. Nim, S.; Mónico, A.; Rawal, M.K.; Duarte, N.; Prasad, R.; Di Pietro, A.; Ferreira, M.-J.U.. "Overcoming Multidrug Resistance in Candida albicans: Macrocyclic Diterpenes from Euphorbia Species as Potent Inhibitors of Drug Efflux Pumps". Planta Medica (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84965006976&partnerID=MN8TOARS.
    10.1055/s-0042-106169
  19. Wisniewski, J.; Wesolowska, O.; Sroda-Pomianek, K.; Paprocka, M.; Bielawska-Pohl, A.; Krawczenko, A.; Duarte, N.; et al. "Euphorbia species-derived diterpenes and coumarins as multidrug resistance modulators in human colon carcinoma cells". Anticancer Research 36 5 (2016): 2259-2264. http://www.scopus.com/inward/record.url?eid=2-s2.0-85017889260&partnerID=MN8TOARS.
  20. Matos, A.M.; Reis, M.; Duarte, N.; Spengler, G.; Molnár, J.; Ferreira, M.-J.U.. "Epoxylathyrol Derivatives: Modulation of ABCB1-Mediated Multidrug Resistance in Human Colon Adenocarcinoma and Mouse T-Lymphoma Cells". Journal of Natural Products 78 9 (2015): 2215-2228. http://www.scopus.com/inward/record.url?eid=2-s2.0-84942693549&partnerID=MN8TOARS.
    10.1021/acs.jnatprod.5b00370
  21. Baptista, R.; Madureira, A.M.; Jorge, R.; Adão, R.; Duarte, A.; Duarte, N.; Lopes, M.M.; Teixeira, G.. "Antioxidant and antimycotic activities of two native Lavandula species from Portugal". Evidence-based Complementary and Alternative Medicine 2015 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84928485652&partnerID=MN8TOARS.
    10.1155/2015/570521
  22. Vieira, C.; Duarte, N.; Reis, M.A.; Spengler, G.; Madureira, A.M.; Molnár, J.; Ferreira, M.-J.U.. "Improving the MDR reversal activity of 6,17-epoxylathyrane diterpenes". Bioorganic and Medicinal Chemistry 22 22 (2014): 6392-6400. http://www.scopus.com/inward/record.url?eid=2-s2.0-84908377069&partnerID=MN8TOARS.
    10.1016/j.bmc.2014.09.041
  23. Ferreira, M.-J.U.; Duarte, N.; Reis, M.; Madureira, A.M.; Molnár, J.. "Euphorbia and Momordica metabolites for overcoming multidrug resistance". Phytochemistry Reviews 13 4 (2014): 915-935. http://www.scopus.com/inward/record.url?eid=2-s2.0-84912045745&partnerID=MN8TOARS.
    10.1007/s11101-014-9342-8
  24. Luo, X.; Pires, D.; Aínsa, J.A.; Gracia, B.; Duarte, N.; Mulhovo, S.; Anes, E.; Ferreira, M.-J.U.. "Zanthoxylum capense constituents with antimycobacterial activity against Mycobacterium tuberculosis in vitro and ex vivo within human macrophages". Journal of Ethnopharmacology 146 1 (2013): 417-422. http://www.scopus.com/inward/record.url?eid=2-s2.0-84874112005&partnerID=MN8TOARS.
    10.1016/j.jep.2013.01.013
  25. Luo, X.; Pedro, L.; Milic, V.; Mulhovo, S.; Duarte, A.; Duarte, N.; Ferreira, M.-J.U.. "Antibacterial benzofuran neolignans and benzophenanthridine alkaloids from the roots of Zanthoxylum capense". Planta Medica 78 2 (2012): 148-153. http://www.scopus.com/inward/record.url?eid=2-s2.0-84856270569&partnerID=MN8TOARS.
    10.1055/s-0031-1280289
  26. Reis, M.; Ferreira, R.J.; Serly, J.; Duarte, N.; Madureira, A.M.; Santos, D.J.V.A.; Molnár, J.; Ferreira, M.-J.U.. "Colon adenocarcinoma multidrug resistance reverted by Euphorbia diterpenes: Structure-activity relationships and pharmacophore modeling". Anti-Cancer Agents in Medicinal Chemistry 12 9 (2012): 1015-1024. http://www.scopus.com/inward/record.url?eid=2-s2.0-84872231481&partnerID=MN8TOARS.
    10.2174/187152012803529655
  27. Valente, I.; Reis, M.; Duarte, N.; Serly, J.; Molnár, J.; Ferreira, M.-J.U.. "Jatrophane diterpenes from euphorbia mellifera and their activity as P-glycoprotein modulators on multidrug-resistant mouse lymphoma and human colon adenocarcinoma cells". Journal of Natural Products 75 11 (2012): 1915-1921. http://www.scopus.com/inward/record.url?eid=2-s2.0-84870204747&partnerID=MN8TOARS.
    10.1021/np3004003
  28. Wesolowska, O.; Wisniewski, J.; Sroda-Pomianek, K.; Bielawska-Pohl, A.; Paprocka, M.; Dus, D.; Duarte, N.; Ferreira, M.-J.U.; Michalak, K.. "Multidrug resistance reversal and apoptosis induction in human colon cancer cells by some flavonoids present in citrus plants". Journal of Natural Products 75 11 (2012): 1896-1902. http://www.scopus.com/inward/record.url?eid=2-s2.0-84870216847&partnerID=MN8TOARS.
    10.1021/np3003468
  29. Wesolowska, O.; Wisniewski, J.; Bielawska-Pohl, A.; Paprocka, M.; Duarte, N.; Ferreira, M.-J.U.; Dus, D.; Michalak, K.. "Stilbenes as multidrug resistance modulators and apoptosis inducers in human adenocarcinoma cells". Anticancer Research 30 11 (2010): 4587-4593. http://www.scopus.com/inward/record.url?eid=2-s2.0-78650252900&partnerID=MN8TOARS.
  30. Lage, H.; Duarte, N.; Coburger, C.; Hilgeroth, A.; Ferreira, M.J.U.. "Antitumor activity of terpenoids against classical and atypical multidrug resistant cancer cells". Phytomedicine 17 6 (2010): 441-448. http://www.scopus.com/inward/record.url?eid=2-s2.0-77950297689&partnerID=MN8TOARS.
    10.1016/j.phymed.2009.07.009
  31. Pusztai, R.; Abrantes, M.; Sherly, J.; Duarte, N.; Molnar, J.; Ferreira, M.-J.U.. "Antitumor-promoting activity of lignans: Inhibition of human cytomegalovirus IE gene expression". Anticancer Research 30 2 (2010): 451-454. http://www.scopus.com/inward/record.url?eid=2-s2.0-77950544499&partnerID=MN8TOARS.
  32. Duarte, N.; Lage, H.; Abrantes, M.; Ferreira, M.-J.U.. "Phenolic compounds as selective antineoplasic agents against multidrug-resistant human cancer cells". Planta Medica 76 10 (2010): 975-980. http://www.scopus.com/inward/record.url?eid=2-s2.0-77954916701&partnerID=MN8TOARS.
    10.1055/s-0029-1240892
  33. Spengler, G.; Ramalhete, C.; Martins, M.; Martins, A.; Serly, J.; Viveiros, M.; Molnár, J.; et al. "Evaluation of cucurbitane-type triterpenoids from Momordica balsamina on P-glycoprotein (ABCB1) by flow cytometry and real-time fluorometry". Anticancer Research 29 10 (2009): 3989-3993. http://www.scopus.com/inward/record.url?eid=2-s2.0-71949083688&partnerID=MN8TOARS.
  34. Teisseyre, A.; Duarte, N.; Ferreira, M.-J.U.; Michalak, K.. "Influence of the multidrug transporter inhibitors on the activity of KV1.3 voltage-gated potassium channels". Journal of Physiology and Pharmacology 60 1 (2009): 69-76. http://www.scopus.com/inward/record.url?eid=2-s2.0-65949088566&partnerID=MN8TOARS.
  35. Duarte, N.; Ramalhete, C.; Varga, A.; Molnár, J.; Ferreira, M.-J.U.. "Multidrug resistance modulation and apoptosis induction of cancer cells by terpenic compounds isolated from Euphorbia species". Anticancer Research 29 11 (2009): 4467-4472. http://www.scopus.com/inward/record.url?eid=2-s2.0-75149181690&partnerID=MN8TOARS.
  36. Duarte, N.; Járdánházy, A.; Molnár, J.; Hilgeroth, A.; Ferreira, M.-J.U.. "Synergistic interaction between p-glycoprotein modulators and epirubicine on resistant cancer cells". Bioorganic and Medicinal Chemistry 16 20 (2008): 9323-9330. http://www.scopus.com/inward/record.url?eid=2-s2.0-53249105258&partnerID=MN8TOARS.
    10.1016/j.bmc.2008.08.071
  37. Duarte, N.; Lage, H.; Ferreira, M.-J.U.. "Three new jatrophane polyesters and antiproliferative constituents from Euphorbia tuckeyana". Planta Medica 74 1 (2008): 61-68. http://www.scopus.com/inward/record.url?eid=2-s2.0-39149087948&partnerID=MN8TOARS.
    10.1055/s-2007-993765
  38. Duarte, N.; Kayser, O.; Abreu, P.; Ferreira, M.J.U.. "Antileishmanial activity of piceatannol isolated from Euphorbia lagascae seeds". Phytotherapy Research 22 4 (2008): 455-457. http://www.scopus.com/inward/record.url?eid=2-s2.0-42949100387&partnerID=MN8TOARS.
    10.1002/ptr.2334
  39. Abrantes, M.; Mil-Homens, T.; Duarte, N.; Lopes, D.; Cravo, P.; Do Céu Madureira, M.; Ferreira, M.-J.U.. "Antiplasmodial activity of lignans and extracts from Pycnanthus angolensis". Planta Medica 74 11 (2008): 1408-1412. http://www.scopus.com/inward/record.url?eid=2-s2.0-52949122155&partnerID=MN8TOARS.
    10.1055/s-2008-1081317
  40. Duarte, N.; Ferreira, M.-J.U.; Martins, M.; Viveiros, M.; Amaral, L.. "Antibacterial activity of ergosterol peroxide against Mycobacterium tuberculosis: Dependence upon system and medium employed". Phytotherapy Research 21 7 (2007): 601-604. http://www.scopus.com/inward/record.url?eid=2-s2.0-34447558018&partnerID=MN8TOARS.
    10.1002/ptr.2119
  41. Duarte, N.; Varga, A.; Cherepnev, G.; Radics, R.; Molnár, J.; Ferreira, M.-J.U.. "Apoptosis induction and modulation of P-glycoprotein mediated multidrug resistance by new macrocyclic lathyrane-type diterpenoids". Bioorganic and Medicinal Chemistry 15 1 (2007): 546-554. http://www.scopus.com/inward/record.url?eid=2-s2.0-33750953574&partnerID=MN8TOARS.
    10.1016/j.bmc.2006.09.028
  42. Wesolowska, O.; Wisniewski, J.; Duarte, N.; Ferreira, M.-J.U.; Michalak, K.. "Inhibition of MRP1 transport activity by phenolic and terpenic compounds isolated from Euphorbia species". Anticancer Research 27 6 B (2007): 4127-4133. http://www.scopus.com/inward/record.url?eid=2-s2.0-37549037789&partnerID=MN8TOARS.
  43. Duarte, N.; Ferreira, M.-J.U.. "Lagaspholones A and B: Two new jatropholane-type diterpenes from euphorbia iagascae". Organic Letters 9 3 (2007): 489-492. http://www.scopus.com/inward/record.url?eid=2-s2.0-33847079662&partnerID=MN8TOARS.
    10.1021/ol062854f
  44. Pusztai, R.; Ferreira, M.-J.U.; Duarte, N.; Engi, H.; Molnar, J.. "Macrocyclic lathyrane diterpenes as antitumor promoters". Anticancer Research 27 1 A (2007): 201-206. http://www.scopus.com/inward/record.url?eid=2-s2.0-33847658888&partnerID=MN8TOARS.
  45. Duarte, N.; Gyémánt, N.; Abreu, P.M.; Molnár, J.; Ferreira, M.J.U.. "New macrocyclic lathyrane diterpenes, from Euphorbia lagascae, as inhibitors of multidrug resistance of tumour cells". Planta Medica 72 2 (2006): 162-168. http://www.scopus.com/inward/record.url?eid=2-s2.0-33644534548&partnerID=MN8TOARS.
    10.1055/s-2005-873196
  46. Ferreira, M.-J.U.; Duarte, N.; Gyémánt, N.; Radics, R.; Cherepnev, G.; Varga, A.; Molnár, J.. "Interaction between doxorubicin and the resistance modifier stilbene on multidrug resistant mouse lymphoma and human breast cancer cells". Anticancer Research 26 5 A (2006): 3541-3546. http://www.scopus.com/inward/record.url?eid=2-s2.0-33750696293&partnerID=MN8TOARS.
  47. Da Silva Dias Duarte, N.M.; Do Nascimento, J.M.. "Pharmacological actions of proanthocyanidins". Revista Portuguesa de Farmacia 48 1 (1998): 9-12. http://www.scopus.com/inward/record.url?eid=2-s2.0-0344972877&partnerID=MN8TOARS.
  48. Tavares, O.S.; Duarte, N.D.; Cunha, S.O.; Ascenso, J.R.; Ferreira, M.J.U.. "Triterpenoids from Euphorbia boetica". Fitoterapia 66 6 (1995): 551-552. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029558311&partnerID=MN8TOARS.
Capítulo de livro
  1. Duarte, Noélia; Ramalhete, Cátia; Rijo, Patrícia; Reis, Mariana Alves; Ferreira, Maria-José U.. "Stilbenoids in Grapes and Wine". In Handbook of Dietary Phytochemicals, 1-28. Springer Singapore, 2020.
    No prelo • 10.1007/978-981-13-1745-3_21-1
  2. Duarte, N.; Ramalhete, C.; Lourenço, L.. "Plant Terpenoids as Lead Compounds Against Malaria and Leishmaniasis". 243-306. 2019.
    10.1016/B978-0-444-64185-4.00007-1
  3. Duarte, Noélia. "Isolation and Structural Identification of Piperine, the Major Alkaloid of Black Pepper". 2017.
    Publicado
  4. Duarte, Noélia. "Reversal of multidrug resistance by macrocyclic and polycyclic diterpenoids from Euphorbia species". 193-213. 2012.
    Publicado
  5. Ferreira, M.-J.U.; Duarte, N.-A.; Michalak, K.; Varga, A.; Molnár, J.. "Piceatannol, an antitumor compound from euphorbia lagascae seeds". 2011.
    10.1016/B978-0-12-375688-6.10054-4
Relatório
  1. Cavaco, Marco; Mateus, Maria Luísa Andrade, 1962-; Duarte, Noélia Maria da Silva Dias, 1970-. 2012. Pesquisa de resíduos de pesticidas em saladas prontas a consumir. http://hdl.handle.net/10451/7718.
Tese / Dissertação
  1. Duarte, Noélia Maria da Silva Dias, 1970-. "Structural characterization and biological activities of terpenic and phenolic compounds isolated from Euphorbia lagascae and Euphorbia tuckeyana". Doutoramento, 2008. http://sibul.reitoria.ul.pt/F/?func=item-global&doc_library=ULB01&type=03&doc_number=000531328.
  2. Duarte, Noélia. "Contribuição para o estudo do pó de cortiça e da cortiça - extracção de proantocianidinas". Mestrado, Universidade de Lisboa Faculdade de Farmácia, 1999.

Outros

Outra produção
  1. Spengler, Gabriela; Ramalhete, Cátia; Martins, Marta; Martins, Ana; Serly, J.; Viveiros, Miguel; Molnar, Joseph; et al. 2009. Evaluation of cucurbitane-type triterpenoids from Momordica balsamina on P-glycoprotein (ABCB1) by flow cytometry and real-time fluorometry.. BACKGROUND: Cancer cells become refractory to chemotherapy as a consequence of their overexpressing ABC transporters that extrude not only the therapeutic agent but other unrelated compounds such as chemotoxins and biocides before they can reach their intended targets. A compound that can inhibit the activity of these transporters may find use as an adjunct to chemotherapy that had been rendered i. http://hdl.handle.net/10884/1321.
  2. Spengler, Gabriella; Ramalhete, Catia; Martins, Marta; Martins, Ana; Serly, Julianna; Viveiros, Miguel; Molnar, Joseph; et al. 2009. Evaluation of Cucurbitane-type Triterpenoids from Momordica balsamina on P-Glycoprotein (ABCB1) by Flow Cytometry and Real-time Fluorometry. Background: Cancer cells become refractory to chemotherapy as a consequence of their overexpressing ABC transporters that extrude not only the therapeutic agent but other unrelated compounds such as chemotoxins and biocides before they can reach their intended targets. A compound that can inhibit the activity of these transporters may find use as an adjunct to chemotherapy that had been rendered i. http://hdl.handle.net/10451/21454.
  3. Duarte, Noelia; Ramalhete, Catia; Varga, Andras; Molnar, Joseph; Ferreira, Maria-Jose U.. 2009. Multidrug Resistance Modulation and Apoptosis Induction of Cancer Cells by Terpenic Compounds Isolated from Euphorbia Species. Background: One of the most promising strategies to overcome multidrug resistance (MDR) is to use compounds that can modulate P-glycoprotein and restore the cytotoxicity of anticancer drugs. Furthermore, the search for compounds that regulate and overcome apoptosis deficiency of cancer cells is also of great therapeutic importance. Materials and Methods: Seven known pentacyclic triterpenes and one. http://hdl.handle.net/10451/21456.
  4. Duarte, Noélia; Ramalhete, Cátia; Varga, A.; Molnar, Joseph; Ferreira, Maria José. 2009. Multidrug resistance modulation and apoptosis induction of cancer cells by terpenic compounds isolated from Euphorbia species.. BACKGROUND: One of the most promising strategies to overcome multidrug resistance (MDR) is to use compounds that can modulate P-glycoprotein and restore the cytotoxicity of anticancer drugs. Furthermore, the search for compounds that regulate and overcome apoptosis deficiency of cancer cells is also of great therapeutic importance. MATERIALS AND METHODS: Seven known pentacyclic triterpenes and one. http://hdl.handle.net/10884/1320.
  5. Michalak, Krystyna; Wesolowska, Olga; Wisniewski, Jerzy; Sroda, Kamila; Teisseyre, Andrzej; Kuzdzal, Michal; Strancar, Janez; Duarte, Noelia; Ferreira, Maria-Jose U.. 2008. ANTICANCER PROPERTIES AND MDR MODULATORY EFFECT OF PLANT POLYPHENOLS AND THEIR INTERACTION WITH MEMBRANE COMPONENTS. http://hdl.handle.net/10451/21654.
  6. Duarte, Noelia; Lage, Hermann; Ferreira, Maria-Jose U.. 2008. Three new jatrophane polyesters and anti proliferative constituents from Euphorbia tuckeyana. Three new jatrophane diterpene polyesters named tuckeyanols A and B and euphotuckeyanol, as well as ten known compounds, helioscopinolides A, 13, D and E, naringenin, aromadendrin, coniferaldehyde, 4,20-dideoxy-5-hydroxyphorbol 12,13-diisobutyrate, 4,20-dideoxy-5-hydroxyphorbol 12-benzoate-13-isobutyrate and dehydrodiconiferyl diacetate, were isolated from the methanolic extract of Euphorbia tucke. http://hdl.handle.net/10451/21648.
    http://dx.doi.org/10.1055/s-2007-993765
  7. Duarte, Noelia; Lage, Hermann; Ferreira, Maria-Jose U.. 2008. ANTINEOPLASIC ACTIVITY OF PHENOLIC COMPOUNDS AGAINST SENSITIVE AND RESISTANT HUMAN CANCER CELLS. http://hdl.handle.net/10451/21447.
  8. Ferreira, Maria-Jose U.; Duarte, Noelia; Jardanhazy, Anett; Madureira, Ana-Margarida; Ramalhete, Catia; Ocsovszki, Imre; Molnar, Joseph. 2008. MACROCYCLIC DITERPENES AS LEAD COMPOUNDS FOR THE DEVELOPMENT OF P-GLYCOPROTEIN MODULATORS IN MULTIDRUG-RESISTANT CANCER CELLS. http://hdl.handle.net/10451/20933.
  9. Ferreira, MJU; Duarte, Noélia; Járdánházy, Anett; Madureira, AM; Ramalhete, C; Molnar, Joseph. 2008. Macrocyclic lathyrane and jatrophane diterpenes as P-glycoprotein modulators in multi-drug-resistant cancer cells. http://hdl.handle.net/10451/22003.
  10. Abrantes, Marta; Mill-Homens, Tania; Duarte, Noelia; Lopes, Dinora; Cravo, Pedro; Madureira, Maria do Ceu; Ferreira, Maria-Jose U.. 2008. Antiplasmodial Activity of Lignans and Extracts from Pycnanthus angolensis. The dichloromethane, methanol and aqueous ethanol extracts of the stem bark of Pycnanthus angolensis were evaluated for their in vitro activity against the 3D7 Plasmodium falciparum strain. The CH2Cl2 extract was the most active showing an IC50 = 1.6 mu g/mL. From this extract, a new dibenzylbutane lignan, threo-4,4'-dihydroxy-3-methoxylignan (1) named pycnantolol, together with the known lignans. http://hdl.handle.net/10451/21446.
    http://dx.doi.org/10.1055/s-2008-1081317
  11. Duarte, Noelia; Jardanhazy, Anett; Molnar, Joseph; Hilgeroth, Andreas; Ferreira, Maria-Jose U.. 2008. Synergistic interaction between p-glycoprotein modulators and epirubicine on resistant cancer cells. The macrocyclic lathyrane diterpene latilagascene B, previously isolated from Euphorbia lagascae, was acylated to afford three new diterpene esters, latilagascenes G (1), H (2), and I (3), whose structures were assigned by spectroscopic methods. These acyl derivatives, and the macrocyclic diterpenes of the jatro-phane-type, tuckeyanols A (4) and B (5), and euphotuckeyanol (6), isolated from Euphor. http://hdl.handle.net/10451/21445.
    http://dx.doi.org/10.1016/j.bmc.2008.08.071
  12. Duarte, Noelia; Kayser, Oliver; Abreu, Pedro; Ferreira, Maria-Jose U.. 2008. Antileishmanial activity of piceatannol isolated from Euphorbia lagascae seeds. In the search for biologically active compounds from Euphorbia lagascae Spreng, an herbaceous plant native to southeast of Iberic Peninsula, a stilbene, two coumarins and two 1-2-deoxyphorbol diterpene esters were isolated by chromatographic methods, from the methanol extracts of its defatted seeds. The structures of these compounds were elucidated by a combination of physical and spectral data (I. http://hdl.handle.net/10451/21649.
    http://dx.doi.org/10.1002/ptr.2334
  13. Duarte, Noelia; Varga, Andras; Cherepnev, Georg; Radics, Rita; Molnar, Joseph; Ferreira, Maria-Jose U.. 2007. Apoptosis induction and modulation of P-glycoprotein mediated multidrug resistance by new macrocyclic lathyrane-type diterpenoids. The macrocyclic lathyrane diterpenes, latilagascenes D-F (1-3) and jolkinol B (4), were isolated from the methanol extract of Euphorbia lagascae, and evaluated for multidrug resistance reversing activity on mouse lymphoma cells. All compounds displayed very strong activity compared with that of the positive control, verapamil. The structure-activity relationship is discussed. The evaluation of com. http://hdl.handle.net/10451/21437.
    http://dx.doi.org/10.1016/j.bmc.2006.09.028
  14. Duarte, Noelia; Ferreira, Maria-Jose U.. 2007. Lagaspholones A and B. Two new diterpenes, lagaspholones A (1) and B (2), have been isolated from the methanolic extract of Euphorbia lagascae, along with the known compounds (+)-dehydrovomifoliol, scopoletin, dehydrodiconiferyl diacetate, 3-indolcarbaldehyde, and 4-hydroxy-3,5-dimethoxybenzaldehyde. Their structures were elucidated by spectroscopic methods. Compounds 1 and 2 contain the rare jatropholane-type skeleton,. http://hdl.handle.net/10451/21438.
    http://dx.doi.org/10.1021/ol062854f
  15. Wesolowska, Olga; Wisniewski, Jerzy; Duarte, Noelia; Ferreira, Maria-Jose U.; Michalak, Krystyna. 2007. Inhibition of MRP1 transport activity by phenolic and terpenic compounds isolated from Euphorbia species. Background: A search for inhibitors of multidrug resistance (MDR)-associated protein 1 (MRP1) was performed among the compounds isolated from Euphorbia species, plants traditionally used in folk medicine. Materials and Methods: Fifteen compounds with terpenic or phenolic structures (macrocyclic and polycyclic diterpenes, coumarins, stilbenes and flavonoids) were isolated from the methanol extracts. http://hdl.handle.net/10451/21657.
  16. Duarte, Noelia; Ferreira, Maria-Jose U.; Martins, Marta; Viveiros, Miguel; Amaral, Leonard. 2007. Antibacterial activity of ergosterol peroxide against Mycobacterium tuberculosis. Ergosterol peroxide, cycloart-23-en-3 beta,25-diol, vanillin and 4-hydroxybenzaldehyde have been isolated and characterized from a crude methanol extract of Euphorbia lagascae. Previous studies have shown contradictory results about the antibacterial activity of ergosterol peroxide against Mycobacterium tuberculosis. In order to clarify this question, the activity of this compound was tested again. http://hdl.handle.net/10451/21440.
    http://dx.doi.org/10.1002/ptr.2119
  17. Ferreira, Maria-Jose U.; Duarte, Noelia; Gyemant, Nora; Radics, Rita; Cherepnev, Georgy; Varga, Andras; Molnar, Joseph. 2006. Interaction between doxorubicin and the resistance modifier stilbene on multidrug resistant mouse lymphoma and human breast cancer cells. The hydroxystilbene trans-3,5,3,4-tetrahydroxystilbene (piceatannol) (1), isolated from the methanol extract of Euphorbia lagascae defatted seeds, was methylated to yield the derivatives trans-3,5,3,4'-tetramethoxystilbene (2), (trans-3,5-dihydroxy-3', 4'-dimethoxystilbene) (3) and trans-3,5,3'-trihydroxy4'-methoxystilbene (4). The structures of the compounds were assigned by spectroscopic methods. http://hdl.handle.net/10451/21436.
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2019/10/09 HPLC-ESI-MS/MS as a valuable to unravel the metabolism of new psychoactive substances 1st Iberian Meeting in Separation Sciences & Mass Spectrometry
(Santiago de Compostela, Espanha)
2019/10 Studies on the metabolism of synthetic cathinones N-ethylhexedrone and buphedrone using liquid chromatography-mass spectrometry (LC-MS/MS) Lisbon Addictions 2019 - Third European Conference on Addictive Behaviours and Dependencies
(LIsboa, Portugal)

Orientação

Título / Tema
Papel desempenhado
Curso (Tipo)
Instituição / Organização
2017 - Atual Bioactive terpenoids from Euphorbia pubescens: isolation and derivatization
Orientador de João Paulo Magalhães Carréu
Universidade de Lisboa Faculdade de Farmácia, Portugal
2017 - 2019 Formulation of carotenoids as natural preservatives and colorants in food industry
Coorientador de Patrícia Isabel Gonçalves Oliveira
Universidade de Lisboa Faculdade de Farmácia, Portugal
2017 - 2019 Actividade antibacteriana dos constituintes químicos da planta medicinal africana Grewia hexamita contra bactérias resistentes
Coorientador de Sara Filipa Santos Jogo
Universidade de Lisboa Faculdade de Farmácia, Portugal
2015 - 2017 Development of a small library of bioactive compounds through isolation and molecular derivatization
Coorientador de João Nuno Gomes
Mestrado em Química Farmacêutica e Terapêutica (Mestrado)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2014 - 2015 Pesquisa de Compostos com Atividade Antiproliferativa de Plantas Medicinais Africanas
Coorientador de Jorge Silva
Universidade de Lisboa Faculdade de Farmácia, Portugal
2012 - 2014 Anticancer Properties of terpenoids in resistant cancer cells
Coorientador de Sara Neto
Universidade de Lisboa Faculdade de Farmácia, Portugal
2012 - 2013 Development of a small library of macrocyclic diterpenes through molecular derivatization
Coorientador de Ana Marta de Matos
Universidade de Lisboa Faculdade de Farmácia, Portugal
2012/01 - 2012/05 Isolation and structure characterization of potential bioactive compounds from Euphorbia boetica
Orientador de Giorgio Daniotti
Università degli Studi di Pavia, Itália
2011 - 2012 Compostos bioativos isolados de Euphorbia boetica – Modulação da glicoproteína-P
Coorientador de Cátia Vicente Vieira
Universidade de Lisboa Faculdade de Farmácia, Portugal
2011 - 2012 Pesquisa de resíduos de pesticidas em saladas prontas a consumir
Coorientador de Marco Calvinho Cavaco
2010 - 2011 Pesquisa de metabolitos secundários bioativos a partir de espécies do género Euphorbia
Orientador de Catarina Sofia Feliciano Pires
2008 - 2009 Pesquisa de compostos com atividade moduladora da multirresistência em células tumorais
Coorientador de Ana Rita Martins Angelino

Júri de grau académico

Tema
Tipo de participação
Nome do candidato (Tipo de grau)
Instituição / Organização
2021/01/28 Perfil Metabólico de Catinonas Sintéticas in vitro: Identificação de metabolitos de Fase I por Espectrometria de Massa de Alta Resolução
Arguente principal
Ana Margarida Alves Figueira (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2020/11/26 Análise Microbiológica da água: técnica de PCR
Arguente
Carolina de Lemos Coelho (Mestrado)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2020/11/23 Determination of Lead levels in lettuces harvested in different urban environments
Arguente
Joana Raquel Vieira Salvado (Mestrado)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2020/06/23 Bioactive terpenoids from Euphorbia pubescens: isolation and derivatization
Orientador
João Paulo Carréu (Mestrado)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2019/12/20 Antibacterial activity of the chemical constituents of the african medicinal plant Grewia hexamita against resistant bacteria
Orientador
Sara Filipa Santos Jogo (Mestrado)
2019/12/03 Teor de Açúcares em Néctares de Fruta e Impacto na Saúde do Consumidor
Arguente
Tânia Luísa Pereira Marques Simões (Mestrado)
2019/11/29 Implementação e validação de um método cromatográfico para a determinação de octilfenóis e octilfenóis etoxilados (OF/OFEs) em águas residuais
Arguente
Bárbara Rita Dias Pereira (Mestrado)
2019/05/20 Composição nutricional e bioactividade de frutas e hortícolas: estudo de sumos detox
Arguente
Maria Inês Leitão de Carvalho Santos (Mestrado)
2017/12/22 Development of a small library of bioactive compounds through isolation and molecular derivatization
Orientador
João Nuno da Silva Gomes (Mestrado)
2017/12/22 Compostos com actividade antitumoral da planta africana Momordica balsamina L.
Arguente
Cristina Isabel Duarte Silva (Mestrado)
2017/12/19 Compostos fenólicos em leguminosas: caracterização da fracção livre e ligada
Arguente
Catarina Isabel Madeira da Conceição Nunes Cardoso (Mestrado)
2017/12/14 Amido resistente e compostos voláteis em diferentes variedades de feijão. Desenvolvimento de uma bolacha à base de farinha de feijão
Arguente
Verónica Silva Gomes (Mestrado)
2017/12/13 Implementação e validação do método TODA-AAS para a monitorização do mercúrio em lamas de ETA e de ETAR
Arguente
Salomé da Visitação Velho Fletcher (Mestrado)
2017/10/25 Reversing multidrug resistance (MDR) in cancer cells by targeting p-glycoprotein (P-gp) : insights into the mechanism of MDR reversal from in silico P-gp modeling
Arguente
Ricardo José Diogo Grácio Ferreira (Doutoramento)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2017/01/11 Caracterização química e avaliação das propriedades biológicas de resíduos provenientes da indústria da cortiça
Arguente principal
Rui Filipe da Silva Lúcio Gomes (Mestrado)
2016/11/08 Unravelling new ethnopharmacological roles of Plectranthus species: biological activity screening
Arguente
Joana Eulália da Cruz Marçalo de Andrade (Mestrado)
2016/01/29 Avaliação da actividade antimicrobiana de metabolitos secundários isolados a partir de uma planta usada na medicina tradicional africana
Arguente
Shirley Arnie dos Reis Sancha (Mestrado)
2015/11/23 Terpenoids as effective compounds for overcomimg multidrug resistance in cancer cells
Arguente
Mariana Alves Reis (Doutoramento)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2015/07/06 Identificação e caracterização por espectrometria de massa com ionizaçãopor eletrospray de antimaláricos que actuam na cadeia mitocondrial de transporte de electrões
Arguente
Ana Raquel Sitoé (Doutoramento)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2014/05/21 Actividade antibacteriana dos constituintes químicos da planta medicinal africana Cleistochlamys kirkii
Arguente
Ângelo Filipe Almeida Monteiro (Mestrado)
2014/02/03 Anticancer properties of terpenois in resistant cancer cells
Orientador
Sara Cristina dos Santos Neto (Mestrado)
2012/06/11 Compostos bioativos de Opuntia ficus indica
Arguente
Ana Catarina Jorge Semedo (Mestrado)
2012/03/14 Compostos bioativos isolados de Euphorbia boetica – Modulação da glicoproteína-P
Orientador
Cátia Vicente Vieira (Mestrado)
2010/09/27 Search for bioactive compounds from medicinal plants used as antimalarials. The study of Momordica balsamina L.
Arguente
Cátia Beatriz Almeida Ramalhete (Doutoramento)
Universidade de Lisboa Faculdade de Farmácia, Portugal