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Carla completed the Integrated Master in Biomedical Engineering in 2010/07 at the University of Coimbra. Later, she was selected as a Ph.D. student for the Ph.D. Program in Experimental Biology and Biomedicine (PDBEB) of the Center for Neuroscience and Cell Biology, University of Coimbra, Portugal. She received an FCT award to develop her research (2010-2014) at Prof. Rego's lab and in 2015 she concluded her Ph.D. with the thesis entitled "Characterisation of human stem cells and therapeutic strategies involving IGF-1 and shRNA in Huntington's disease". During the Ph.D. she spent 2 years, developing part of the research plan involving stem cells, at Daley's lab, Harvard Medical School, Boston, and at Sandrine Humbert lab, Institut Curie, and Anselm Perrier lab, I-Stem, Paris. In 2015 Carla received a Post-Doctoral fellow grant from the FLAD Grants on Portugal-USA collaborative projects to work on a project entitled "Creation and characterization of neural cells derived from pre-symptomatic and symptomatic Huntington´s disease patient-specific induced pluripotent stem cells" under the supervision of Prof. Rego. In 2018, Carla got a grant funded by FCT as Principal Investigator with the reference POCI-01-0145-FEDER-029621 - "iPS cells-derived exosomes - impact on mitochondrial (dys)function in Huntington's disease and potential nanodelivery system for microRNA-based therapeutics". Carla has also been enrolled in several teaching activities: 2007 -2010 as an Adjunct Teacher at Instituto Politécnico de Coimbra, Escola Superior de Tecnologia da Saúde de Coimbra, Portugal and 2017-2018 as an Invited Adjunct Teacher at Instituto Politécnico de Castelo Branco, Portugal, where she was responsible for the disciplines of Patologia I (theoric classe: 135 h; 5 ECTS) and Patologia II (theoric classe: 135 h; 5 ECTS). In 2019, she was a tutor (University of Coimbra) in the discipline of Applied Research II for the Integrated Master's degree in Medicine. She has also been a supervisor of several graduate and undergraduate students during lab rotations and was co-supervisor and supervisor of Master theses. In addition, Carla participated as a volunteer at the COVID-19 UC Lab (2020). She was a researcher at the Center for Neuroscience and Cell Biology, University of Coimbra under the DL57/2016 of the Portuguese law for scientific and technological employment from 2019 to 2023. She supervised a small team with a research technician, postdoctoral researcher, and master's student. In the last five years, she has participated in 6 projects. She is a reviewer in 11 journals and guest editor in Methods Collections at JoVE and at a special edition at CELLS. She has also been actively engaged with the science communication office and "Ciência Viva" at the Laboratory in programs for public outreach. In the last years, she collaborated in the organization of 3 events and participated in 24. Also, she has received 8 awards and/or honours. In her professional activities, she has interacted with 58 collaborators and co-authorship of scientific papers. In 2019 Carla had a career break for seven months due to clinical risk during pregnancy followed by maternity leave. Currently, Carla is an assistant researcher at the Multidisciplinary Institute of Ageing, University of Coimbra. She has 18 publications in peer-reviewed international journals and conference abstracts: 8 as the first author, 5 as co-author, 5 as the last author, and 2 book chapters; with 532 citations and an h-index of 12 (Google Scholar [14 in Q1 publications and 8 are in top 10%-CiteScore Scopus].
Identificação

Identificação pessoal

Nome completo
Carla Maria Nunes Lopes

Identificadores de autor

Ciência ID
0E10-2833-5AEE
ORCID iD
0000-0002-2543-8821

Endereços de correio eletrónico

  • clopes@uc.pt (Profissional)
  • carlalopes09@gmail.com (Pessoal)

Telefones

Telefone
  • 239855760 (Profissional)

Moradas

  • Multidisciplinary Institute of Ageing - Portugal University of Coimbra Faculdade de Medicina, Polo I, 3º Piso Rua Larga , 3004-504, Coimbra, Coimbra, Portugal (Profissional)

Domínios de atuação

  • Ciências da Engenharia e Tecnologias - Engenharia Médica

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Francês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Espanhol; Castelhano Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador elementar (A1) Utilizador proficiente (C1)
Formação
Grau Classificação
2018/05 - 2018/09
Concluído
Course in Laboratory Animal Science (FELASA category B) (Pós-Graduação)
Direcção-Geral de Alimentação e Veterinária, Portugal
Approved
2010/10/01 - 2015/10/02
Concluído
Experimental Biology and Biomedicine (Doutoramento)
Universidade de Coimbra, Portugal
"Characterization of human stem cells and therapeutic strategies involving IGF-1 and shRNA in Huntington's disease" (TESE/DISSERTAÇÃO)
Approved with praise and distinction
2011/04 - 2013/08
Concluído
Trainee (Postgraduate Certificate)
Especialização em Stem cells
Institut Curie, França
2012 - 2013
Concluído
French course (Curso médio)
Especialização em Foreign Languages and Literatures
The Training Unit at Institut Curie, França
A
2011/09 - 2012/02
Concluído
Advanced Communication Skills in English II (Curso médio)
Especialização em Foreign Languages and Literatures
Universidade de Coimbra Faculdade de Letras, Portugal
A
2011/09 - 2011/12
Concluído
Trainee (Postgraduate Certificate)
Especialização em Stem cells
Children s Hospital Boston at Waltham, Estados Unidos
2010 - 2011
Concluído
Upper Intermediate level of English (Curso médio)
Universidade de Coimbra, Portugal
2005/09 - 2010/07
Concluído
Engenharia Biomédica (Mestrado integrado)
Universidade de Coimbra, Portugal
"Peripheral and cerebral metabolic features in an animal model of Huntington’s disease expressing full-length mutant huntingtin" (TESE/DISSERTAÇÃO)
15
2008/12 - 2009/06
Concluído
Advanced Level English Course (Curso médio)
Especialização em Foreign Languages and Literatures
International House Coimbra, Portugal
A
2009 - 2009
Concluído
Structure -Function correlations in Biomedicine: lessons from the Nervous System (Curso médio)
Especialização em PhDHS
Universidade de Coimbra Faculdade de Medicina, Portugal
18
2003 - 2004
Concluído
Advanced English Conversation Course (Curso médio)
Especialização em Linguas
International house, Portugal
2003 - 2003
Concluído
MS Office course (Curso médio)
SadoInformática, Portugal
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento
Empregador
2023/01/03 - Atual Investigador Auxiliar (carreira) (Investigação) University of Coimbra- Multidisciplinary Institute of Ageing, Portugal
Universidade de Coimbra, Portugal
2018/07/05 - 2023/01/02 Investigador Contratado (Investigação) Centro de Neurociencias e Biologia Celular, Portugal
Centro de Neurociencias e Biologia Celular, Portugal
2015/12/01 - 2017/11/30 Pós-doutorado (Investigação) Centro de Neurociencias e Biologia Celular, Portugal
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2007/09 - 2008/06 Investigador (Investigação) Universidade de Coimbra, Portugal
Universidade de Coimbra Faculdade de Medicina, Portugal

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento
Empregador
2019/02 - 2019/07 Monitor (Docente Universitário) Universidade de Coimbra Faculdade de Medicina, Portugal
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
(...)
2017/09 - 2018/07 Professor Adjunto Convidado (Docente Ensino Superior Politécnico) Instituto Politécnico de Castelo Branco, Portugal
Instituto Politécnico de Castelo Branco Escola Superior de Saúde Dr Lopes Dias, Portugal
2007/09 - 2011/09 Professor Adjunto (Docente Ensino Superior Politécnico) Instituto Politécnico de Coimbra Escola Superior de Tecnologia da Saúde de Coimbra, Portugal
Instituto Politécnico de Coimbra Escola Superior de Tecnologia da Saúde de Coimbra, Portugal

Outros

Categoria Profissional
Instituição de acolhimento
Empregador
2010/09/01 - 2015/10/02 PhD student Centro de Neurociencias e Biologia Celular, Portugal
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
Projetos

Bolsa

Designação Financiadores
2018/07/05 - 2019/01/31 iPS cells-derived exosomes - impact on mitochondrial (dys)function in Huntington's disease and potential nanodelivery system for microRNA-based therapeutics
POCI-01-0145-FEDER-029621
Bolseiro de Pós-Doutoramento
Centro de Neurociencias e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2013 - 2018 Role of Sirtuin 3 on mitochondrial function and deacetylation of mitochondrial targets: relevance for Huntington's disease.
EXPL/BIM-MEC/2220/2013
Investigador
Centro de Neurociencias e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2015/12/01 - 2017/11/30 Creation and characterization of neural cells derived from pre-symptomatic and symptomatic Huntington´s disease patient-specific induced pluripotent stem cells
FLAD LIFE SCIENCE 2020
Bolseiro de Pós-Doutoramento
Centro de Neurociencias e Biologia Celular, Portugal
Fundação Luso-Americana
Concluído
2010/11/01 - 2014/10/31 Characterization of human stem cells and therapeutic strategies involving IGF-1 and shRNA in Huntington's disease
SFRH / BD / 51192 / 2010
Bolseiro de Doutoramento
Centro de Neurociencias e Biologia Celular, Portugal

Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
Fundação para a Ciencia e Tecnologia
Concluído

Projeto

Designação Financiadores
2021/01/01 - 2025/12/31 Laboratório para a Investigação Integrativa e translacional em Saúde Populacional
LA/P/0064/2020
Universidade do Porto Instituto de Saúde Pública, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2021/01/01 - 2025/12/31 Center for Innovative Biomedicine and Biotechnology - Associate Laboratory
LA/P/0058/2020
Universidade de Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2018/07/05 - 2022/07/04 iPS cells-derived exosomes - impact on mitochondrial (dys)function in Huntington's disease and potential nanodelivery system for microRNA-based therapeutics
POCI-01-0145-FEDER-029621
Investigador responsável
Centro de Neurociencias e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2019/01/01 - 2019/12/31 CNC. IBILI
UID/NEU/04539/2019
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Coimbra, Portugal

Universidade de Coimbra Instituto de Ciências Nucleares Aplicadas à Saúde, Portugal

Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2015 - 2017 Exploring the role of pridopidine on mitochondrial function and dynamics in Huntington's disease models
TEVA Pharmaceutical Industries
Investigador Pós-doutorado
Centro de Neurociencias e Biologia Celular, Portugal
Teva Pharmaceutical Industries Ltd
Concluído

Outro

Designação Financiadores
2007/10 - 2008/05 AGES (Advanced Glycation End Products) and vascular complications in type 2 diabetes
GAPI Medical School
Outra
Universidade de Coimbra Faculdade de Medicina, Portugal
Universidade de Coimbra Faculdade de Medicina
Concluído
Produções

Publicações

Artigo em conferência
  1. Geva, Michel; Naia, Luana; Ly, P; Lopes, Carla; Mota, Sandra I; Maranga, Carina; Hayden, Michael; Rego, Ana Cristina. "Pridopidine Rescues Multiple Mitochondrial Functions Impaired in Human and Mouse HD Models by Activation of the Sigma-1 Receptor". Trabalho apresentado em HSG 2019, 2019.
    Publicado
  2. Lopes, Carla; Duarte, Ana I.; Hayden, Michael; Rego, A. Cristina. "Peripheral and cerebral metabolic features in an animal model of Huntington's disease". 2012.
    10.1109/enbeng.2012.6331390
Artigo em jornal
  1. Lopes, Carla. "Viagens no cérebro em BD", Publico, 2017, https://www.publico.pt/2017/03/24/ciencia/fotogaleria/viagens-no-cerebro-em-bd-371640.
Artigo em revista
  1. Beatriz, Margarida; Ricardo Rodrigues; Rita Pereira Vilaça (B317-85CF-B04B); Conceição Egas; Paulo César Silva Pinheiro; Daley, George Q.; Schlaeger, Thorsten M.; et al. Autor correspondente: Lopes, Carla. "Extracellular vesicles improve GABAergic transmission in Huntington's disease iPSC derived neurons". Theranostics 13 11 (2023): 3707-3724.
    Publicado
  2. Beatriz, Margarida; Vilaça, Rita; Anjo, Sandra I.; Manadas, Bruno; Januário, Cristina; Rego, A. Cristina; Lopes, Carla. Autor correspondente: Lopes, Carla. "Defective mitochondria-lysosomal axis enhances the release of extracellular vesicles containing mitochondrial DNA and proteins in Huntington's disease". Journal of Extracellular Biology 1 10 (2022): e65. http://dx.doi.org/10.1002/jex2.65.
    Publicado • 10.1002/jex2.65
  3. Deus, Cláudia M.; Tavares, Henrique; Beatriz, Margarida; Mota, Sandra; Lopes, Carla. "Mitochondrial Damage-Associated Molecular Patterns Content in Extracellular Vesicles Promotes Early Inflammation in Neurodegenerative Disorders". Cells 11 15 (2022): 2364. http://dx.doi.org/10.3390/cells11152364.
    Acesso aberto • 10.3390/cells11152364
  4. Lopes, Carla; Ferreira, I. Luísa; Maranga, Carina; Beatriz, Margarida; Mota, Sandra I.; Sereno, José; Castelhano, João; et al. "Mitochondrial and redox modifications in early stages of Huntington's disease". Redox Biology (2022): 102424. http://dx.doi.org/10.1016/j.redox.2022.102424.
    10.1016/j.redox.2022.102424
  5. Beatriz, Margarida; Vilaça, Rita; Ana Cristina Carvalho Rego; Lopes, Carla. Autor correspondente: Lopes, Carla. "Defective mitophagic clearance of damaged mitochondria promotes extracellular vesicle-mediated release of mitochondrial components in huntington's disease". European Journal of Clinical Investigation 52 S1 (2022): http://dx.doi.org/10.1111/eci.13796.
    Publicado • 10.1111/eci.13796
  6. Beatriz, Margarida; Lopes, Carla; Ribeiro, Ana Cláudia S.; Rego, Ana Cristina Carvalho. "Revisiting cell and gene therapies in Huntington's disease". Journal of Neuroscience Research 99 7 (2021): 1744-1762. http://dx.doi.org/10.1002/jnr.24845.
    10.1002/jnr.24845
  7. Beatriz, Margarida; Vilaça, Rita; Lopes, Carla. "Exosomes: Innocent bystanders or critical culprits in neurodegenerative diseases". Frontiers in Cell and Developmental Biology (2021): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8155522/.
    Acesso aberto • Publicado
  8. Naia, Luana; Ly, Philip; Mota, Sandra I.; Lopes, Carla; Maranga, Carina; Coelho, Patrícia; Gershoni-Emek, Noga; et al. "The Sigma-1 Receptor Mediates Pridopidine Rescue of Mitochondrial Function in Huntington Disease Models". Neurotherapeutics (2021): http://dx.doi.org/10.1007/s13311-021-01022-9.
    Publicado • 10.1007/s13311-021-01022-9
  9. Naia, Luana; Carmo, Catarina; Campesan, Susanna; Fão, Lígia; Cotton, Victoria E.; Valero, Jorge; Lopes, Carla; et al. "Mitochondrial SIRT3 confers neuroprotection in Huntington's disease by regulation of oxidative challenges and mitochondrial dynamics". Free Radical Biology and Medicine 163 (2021): 163-179. http://dx.doi.org/10.1016/j.freeradbiomed.2020.11.031.
    Acesso aberto • Publicado • 10.1016/j.freeradbiomed.2020.11.031
  10. Lopes, Carla; Tang, Yang; Anjo, Sandra I.; Manadas, Bruno; Onofre, Isabel; de Almeida, Luís P.; Daley, George Q.; Schlaeger, Thorsten M.; Rego, Ana Cristina Carvalho. "Mitochondrial and Redox Modifications in Huntington Disease Induced Pluripotent Stem Cells Rescued by CRISPR/Cas9 CAGs Targeting". Frontiers in Cell and Developmental Biology 8 (2020): 967. http://dx.doi.org/10.3389/fcell.2020.576592.
    Acesso aberto • Publicado • 10.3389/fcell.2020.576592
  11. Beatriz, Margarida; Rita Pereira Vilaça (B317-85CF-B04B); Thorsten Michael Schlaeger; Daley, George Q.; Ana Cristina Carvalho Rego; Lopes, Carla. "Human Huntington's disease iPSC-derived striatal-like neurons display altered maturation and mitochondrial dynamics". European Journal of Clinical Investigation 50 S1 (2020): http://dx.doi.org/10.1111/eci.13369.
    10.1111/eci.13369
  12. Lopes, Carla; Castelhano, Joao; Margarida Fernandes Beatriz (431D-E8EB-DA99); Carolina Fernandes; Mário Laço; Cristina Januário; Abrunhosa, Antero J; Castelo-Branco, Miguel; Ana Cristina Carvalho Rego. "Overreduced intracellular state detected in Cu-ATSM brain imaging and fibroblasts from prodromal Huntington disease carriers". European Journal of Clinical Investigation 50 S1 (2020): http://dx.doi.org/10.1111/eci.13369.
  13. Lopes, Carla; Schlaeger, Thorsten; Pereira de Almeida, Luis ; Daley, George Q.; Ana Cristina Carvalho Rego. "Reversal of mitochondrial abnormalities by CRISPR/Cas9 editing of the mutant HTT allele in vitro in Huntington´s Disease patient-derived pluripotent and neural stem cells". European Journal of Clinical Investigation 49 S1 (2019): 53-100. http://dx.doi.org/10.1111/eci.13108.
    10.1111/eci.13108
  14. Naia, Luana; Carmo, Catarina; Campesan, Susanna; Lopes, Carla; Valero, Jorge; Rosenstock, Tatiana R.; Giorgini, Flaviano; Cristina Rego, A.. "SIRT 3 , a modifier of mitochondrial function in Huntington's disease". Free Radical Biology and Medicine 120 (2018): S17. http://dx.doi.org/10.1016/j.freeradbiomed.2018.04.072.
    Acesso aberto • Publicado
  15. Bacalhau, Mafalda; Simões, Marta; Rocha, Mariana C.; Hardy, Steven A.; Vincent, Amy E.; Durães, João; Macário, Maria C.; et al. "Disclosing the functional changes of two genetic alterations in a patient with Chronic Progressive External Ophthalmoplegia: Report of the novel mtDNA m.7486G>A variant". Neuromuscular Disorders 28 4 (2018): 350-360. http://dx.doi.org/10.1016/j.nmd.2017.11.006.
    Acesso aberto • Publicado • 10.1016/j.nmd.2017.11.006
  16. Naia, Luana; Ribeiro, Márcio; Rodrigues, Joana; Duarte, Ana I.; Lopes, Carla; Rosenstock, Tatiana R.; Hayden, Michael R.; Rego, A. Cristina. "Insulin and IGF-1 regularize energy metabolites in neural cells expressing full-length mutant huntingtin". Neuropeptides 58 (2016): 73-81. http://dx.doi.org/10.1016/j.npep.2016.01.009.
    Publicado • 10.1016/j.npep.2016.01.009
  17. Lopes, Carla; Rego, A. Cristina. "Revisiting Mitochondrial Function and Metabolism in Pluripotent Stem Cells: Where Do We Stand in Neurological Diseases?". Molecular Neurobiology 54 3 (2016): 1858-1873. http://dx.doi.org/10.1007/s12035-016-9714-8.
    Acesso aberto • Publicado • 10.1007/s12035-016-9714-8
  18. Lopes, Carla; Aubert, Sophie; Bourgois-Rocha, Fany; Barnat, Monia; Rego, Ana Cristina; Déglon, Nicole; Perrier, Anselme L.; Humbert, Sandrine; Blum, David. "Dominant-Negative Effects of Adult-Onset Huntingtin Mutations Alter the Division of Human Embryonic Stem Cells-Derived Neural Cells". PLOS ONE 11 2 (2016): e0148680-e0148680. http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0148680.
    Acesso aberto • Publicado • 10.1371/journal.pone.0148680
  19. Lopes, Carla; Ribeiro, Márcio; Duarte, Ana I.; Humbert, Sandrine; Saudou, Frederic; Pereira de Almeida, Luís; Hayden, Michael; Rego, A. Cristina. "IGF-1 Intranasal Administration Rescues Huntington's Disease Phenotypes in YAC128 Mice". Molecular Neurobiology 49 3 (2013): 1126-1142.
    Publicado • 10.1007/s12035-013-8585-5
  20. Lopes, Carla Maria Nunes; Duarte, Ana I.; Hayden, Michael; Ana Cristina Carvalho Rego. "Peripheral and cerebral metabolic features in an animal model of Huntington's disease". IEEE Xplore Digital Library , (2012): 1-5. http://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=6331390&isnumber=6331337.
    Publicado • 10.1109/enbeng.2012.6331390
Capítulo de livro
  1. Lopes, Carla; Raimundo, Nuno. Autor correspondente: Lopes, Carla. "Mitochondria-lysosome crosstalk, in disease and in health". In The Dynamic Nature of Mitochondria: from Ultrastructure to Health and Disease, editado por Taylor & Francis. Boca Raton, Estados Unidos: CRC Press, 2024.
    No prelo
  2. Carmo, Catarina; Naia, Luana; Lopes, Carla; Rego, A. Cristina. "Mitochondrial Dysfunction in Huntington’s Disease". In Advances in Experimental Medicine and Biology, 59-83. Springer International Publishing, 2018.
    10.1007/978-3-319-71779-1_3
Poster em conferência
  1. Lopes, Carla. "Mitochondrial cargo in extracellular vesicles promotes microglia-mediated proinflammatory response". Trabalho apresentado em 3rd RESETageing Conference, 2023.
  2. Lopes, Carla. "EXOSOMES PROMOTE THE RECOVERY FROM SYNAPTIC DYSFUNCTION IN HUMAN HUNTINGTON'S DISEASE IPSC-DERIVED STRIATAL-LIKE NEURONS". Trabalho apresentado em ISSCR2021, 2021.
  3. Beatriz, Margarida; Vilaça, Rita; Rodrigues, Ricardo J.; Daley, GQ; Januário, Cristina; Schlaeger, Thorsten; Rego, Ana Cristina Carvalho (1B13-BB39-7943); Lopes, Carla. "Striatal neurons derived from Huntington's Disease patient's iPSC exhibit mitochondrial dysfunction and electrophysiological impairment". Trabalho apresentado em FENS2020, 2020.
  4. Beatriz, Margarida; Lopes, Carla; Pereira de Almeida, Luís; Daley, GQ; Rego, A. Cristina. "CRISPR/Cas9 mediated silencing of mutant huntingtin in Huntington´s disease patient-derived pluripotent and neural stem cells improves mitochondrial function". Trabalho apresentado em XVI Meeting of the Portuguese Society for Neuroscience, 2019.
  5. Naia, Luana; Ly, P; Mota, SI; Maranga, Carina; Lopes, Carla; Geva, Michel; Hayden, Michael; Rego, A. Cristina. "Pridopidine preserves mitochondrial morphofunction in in vitro and ex vivo Huntington's models through sigma-1 receptor-dependent decrease in oxidative stress". Trabalho apresentado em 14th International Conference on Alzheimer's and Parkinson's Diseases, 2019.
  6. Lopes, Carla; Pereira de Almeida, Luís; Daley, GQ; Rego, A. Cristina. "Huntington's disease patient-derived induced pluripotent stem cells and neural stem cells: insights into early metabolic and mitochondrial defects". Trabalho apresentado em The International Society for Stem Cell Research (ISSCR), 2017.
  7. Lopes, Carla; Pereira de Almeida, Luís; Daley, GQ; Rego, A. Cristina. "Patient-derived induced pluripotent and neural stem cells offer new insights into Huntington's Disease mechanisms". Trabalho apresentado em XV Portuguese Society for Neuroscience meeting, 2017.
  8. Bacalhau, Mafalda; Simões, Marta; Pratas, João; Duque, C; do Carmo Macário, Maria; Fonseca, P; Vaz, M; et al. "Report of a novel mitochondrial ATP8 gene mutation in a patient with severe optic neuropathy: functional demonstration of pathogenicity". Trabalho apresentado em Sociedade Portuguesa de Doenças Metabólicas, 2017.
  9. Bacalhau, Mafalda; Simões, Marta; Pratas, João; Diogo, Luísa; Garcia, Paula; Vaz, Mónica; Santos, Maria J.; et al. "Mitochondrial dysfunction in a lysosomal storage disorder: a case of spinocerebellar ataxia". Trabalho apresentado em MITOPORTO, 2017.
  10. Naia, Luana; Carmo, Catarina; Oliveira, A. M.; Valero, Jorge; Lopes, Carla; Oliveira, C.R.; Rosenstock, Tatiana R.; Rego, A. Cristina. "Exacerbated SIRT3 activity alters mitochondrial function and dynamics in Huntington's disease models". Trabalho apresentado em Society for Neuroscience (SfN) 2016, 2016.
  11. Simões, Marta; Bacalhau, Mafalda; do Carmo Macário, Maria; Lopes, Carla; Rego, A. Cristina; Grazina, Manuela. "Still mitochondrial dysfunction in Leber's hereditary optic neuropathy pathogenesis". Trabalho apresentado em XII SIMPÓSIO INTERNACIONAL DA SOCIEDADE PORTUGUESA DE DOENÇAS METABÓLICAS, 2016.
  12. Lopes, Carla; Pereira de Almeida, Luís; Daley, GQ; Rego, A. Cristina. "nduced pluripotent stem and neural stem cells derived from Huntington´s disease patients unravel early mitochondrial dysfunction and metabolic disturbances". Trabalho apresentado em 9th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies, 2015.
  13. Lopes, Carla; Aubert, Sophie; Bourgois-Rocha, Fany; Rego, A. Cristina; Déglon, Nicole; Perrier, AL; Humbert, Sandrine. "Dominant-negative effects of adult onset mutant huntingtin leads to an altered division of human embryonic stem cells derived neural cells". Trabalho apresentado em ISSCR Annual Meeting, 2015.
  14. Lopes, Carla; Pereira de Almeida, Luís; Daley, GQ; Rego, A. Cristina. "iPS cells derived from huntington´s disease patients exhibit mitochondrial dysfunction and metabolic disturbances". Trabalho apresentado em ISSCR Annual Meeting, 2015.
  15. Lopes, Carla; Pereira de Almeida, Luís; Daley, GQ; Rego, A. Cristina. "iPSC cells derived from Huntington´s Disease patients and their differentiated counterparts exhibit mitochondrial dysfunction and metabolic disturbances". Trabalho apresentado em XIV meeting of the Portuguese Society for Neurosciences, 2015.
  16. Bacalhau, Mafalda; Simões, Marta; Pratas, João; Santos, Maria João; Vaz, Mónica; Zuzarte, Mónica; Lopes, Carla; et al. "Functional genomics analysis to gathering evidence for m.7486G>A mutation pathogenicity". Trabalho apresentado em XIII CNC ANNUAL MEETING, 2015.
  17. Lopes, Carla; Ribeiro, Márcio; Duarte, Ana I.; Humbert, Sandrine; Saudou, Frederic; Pereira de Almeida, Luís; Hayden, Michael; Rego, A. Cristina. "IGF-1 intranasal administration rescues Huntington’s Disease phenotypes in YAC128 mice". Trabalho apresentado em GEECD Meeting, 2014.
  18. Lopes, Carla; Aubert, Sophie; Déglon, Nicole; Perrier, Anselme L.; Humbert, Sandrine; Rego, A. Cristina. "Huntingtin regulates human neuronal stem cells division, a mechanism that is altered in Huntington's disease". Trabalho apresentado em 4th PF2MUC Symposium, 2013.
  19. Lopes, Carla; Ribeiro, Márcio; Duarte, AI; Humbert, Sandrine; Saudou, Frederic; Pereira de Almeida, Luís; Hayden, Michael; Rego, A. Cristina. "IGF-1 intranasal administration rescues Huntington's Disease phenotypes in YAC128 mice". Trabalho apresentado em FENS Forum, 2012.
  20. Lopes, Carla; Duarte, AI; Pereira de Almeida, Luís; Hayden, Michael; Rego, A. Cristina. "Intranasal administration ameliorates Huntington's Disease metabolic profile and alleviates motor impairment in YAC128 mice". Trabalho apresentado em V SPB Clinical Biochemistry Workshop, Translational Molecular Biochemistry, 2012.
  21. Lopes, Carla; Duarte, AI; Oliveira, CR; Rego, A. Cristina. "IGF-1 administration in an animal model of Huntington's disease". Trabalho apresentado em SINAL, 2011.
  22. Lopes, Carla; Coelho, Cristina; Correia, Patricia; Matos, MJ. "Risk factors for Cheyne -Stokes respiration". Trabalho apresentado em 20th Congress of the European Sleep Research Society,, 2010.
  23. Lopes, Carla; Coelho, Cristina; Fradinho, Fatima; Lopes, Paulo; Matos, MJ. "Adverse effects and adherence to autoadjusting positive airway pressure". Trabalho apresentado em European Respiratory Society Congress, 2009.
Resumo em conferência
  1. Geva, Michal; Shenkman, Marina; Naia, Luana; Gershoni Emek, Noga; Ly, Philip; Mota, Sandra I; Lopes, Carla; et al. "I13 Pridopidine restores mitochondrial function and decreases er stress which is mediated through the S1R". 2021.
    10.1136/jnnp-2021-ehdn.127
  2. Lopes, Carla. "FIBROBLASTS-DERIVED EXTRACELLULAR VESICLES REVERT SYNAPTIC DYSFUNCTION IN HUMAN HUNTINGTON'S DISEASE STRIATAL NEURONS". Trabalho apresentado em ESCI 2021, 2021.
    Publicado
  3. Lopes, Carla. "Extracellular vesicles cargo as biomarker of mitochondrial dysfunction in Huntington's Disease". Trabalho apresentado em ISEV2021, 2021.
    Publicado • doi.org/10.1111/eci.13567
Tese / Dissertação
  1. Lopes, Carla Maria Nunes. "Characterization of human stem cells and therapeutic strategies involving IGF-1 and shRNA in Huntington's disease". Doutoramento, 2015. http://hdl.handle.net/10316/28370.
  2. Lopes, Carla Maria Nunes. "Peripheral and cerebral metabolic features in an animal model of Huntington's Disease expressing full-length mutant huntingtin". Mestrado, 2010. http://hdl.handle.net/10316/13790.
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2024/04/24 Decrypting Early Inflammation: The Link Between Mitochondria, Extracellular Vesicles, and Microglia DCV.talks
DCV-UC (Coimbra, Portugal)
2023/10/11 Mitochondrial Cargo in Extracellular Vesicles Promotes Microglia-Mediated Proinflammatory Response Targeting Mitochondria World Congress 2023
World Mitochondria Society (Berlin, Alemanha)
2023/05/13 Mitochondria damage-associated molecular patterns associated to extracellular microvesicles promote microglia-mediated proinflammatory response MITOPORTO
University of Porto - FFUP (Porto, Portugal)
2022/06/09 Defective mitophagic clearance of damage mitochondria promotes extracellular vesicle-mediated release of mitochondrial components in Huntington's Disease ESCI 2022
European Society for Clinical Investigation (Bari, Itália)
2021/10/05 Exosomes promote the recovery from synaptic dysfunction in human Huntington's disease iPSC-derived striatal-like neurons The Synaptic Dimension of Brain Disorders
Universidad Internacional de Andalucía (Baeza, Espanha)
2021/06/10 FIBROBLASTS-DERIVED EXTRACELLULAR VESICLES REVERT SYNAPTIC DYSFUNCTION IN HUMAN HUNTINGTON'S DISEASE STRIATAL NEURONS ESCI 2021 Annual Scientific Meeting
European Society for Clinical Investigation
2021/06/10 Extracellular vesicles from fibroblasts of Huntington's Disease patients are involved in the transfer of mitochondrial components ESCI 2021 Annual Scientific Meeting
European Society for Clinical Investigation
2021/05/18 Extracellular vesicles cargo as biomarker of mitochondrial dysfunction in Huntington's Disease ISEV2021
ISEV
2021/01/20 Exosomes in Huntington's Disease: Innocent bystanders or major culprits? NEUROSCIENCE AND DISEASE THEMATIC LINE
Coimbra Institute for Clinical and Biomedical Research (Portugal)
2020/09/24 Human Huntington's disease iPSC-derived striatal-like neurons display altered maturation and mitochondrial dynamics ESCI Virtual Meeting 2020 | Covid19 edition
European Society for Clinical Investigation
2020/09/22 Overreduced intracellular state detected in Cu-ATSM brain imaging and fibroblasts from prodromal Huntington disease carriers ESCI Virtual Meeting 2020 | Covid19 edition
European Society for Clinical Investigation
2020/07 Doença de Huntington: como é que as células estaminais podem ajudar? Zooming on Science
Center for Neuroscience and Cell Biology (Portugal)
2019/05/23 Reversal of mitochondrial abnormalities by CRISPR/Cas9 editing of the mutant HTT allele in vitro in Huntington's disease patient-derived pluripotent and neural stem cells 53rd Meeting of the European Society for Clinical Investigation
ESCI (Coimbra, Portugal)
2019/03/15 CRISPR/Cas9 mediated silencing of mutant huntingtin in Huntington´s disease patient-derived pluripotent and neural stem cells improves mitochondrial function Congress of Portuguese Movement Disorders Society
Portuguese Movement Disorders Society (Curia, Portugal)
2019/03/15 Radiolabeled Cu-ATS as a novel biomarker for oxidative stress based on mitochondrial dysfunction in huntington’s disease Congress of Portuguese Movement Disorders Society
Portuguese Movement Disorders Society (Curia, Portugal)
2018/05 SIRT3, a modifier of mitochondrial function in Huntington's disease 19th biennial meeting for the Society for Free Radical Research International (SFRRI)
Lisbon Conference Centre (Lisboa, Portugal)
2017/03/16 Report of a novel mitochondrial ATP8 gene mutation in a patient with severe optic neuropathy: functional demonstration of pathogenicity 13º Simpósio Internacional da Sociedade Portuguesa De Doenças Metabólicas
Sociedade Portuguesa De Doenças Metabólicas (Évora, Portugal)
2017 Mitochondrial defects in Huntington's disease: what can we learn from patient-derived induced pluripotent and neural stem cell models? Congress of Portuguese Movement Disorders Society
Portuguese Movement Disorders Society (Ofir, Portugal)
2017 Mitochondrial defects in Huntington’s disease patient-derived induced pluripotent stem cells and differentiated counterpart SPF 2017 - XLVII Reunião Anual Da Sociedade Portuguesa De Farmacologia, XXXV Reunião De Farmacologia Clínica, XVI Reunião de Toxicologia
Sociedade Portuguesa De Farmacologia (Coimbra, Portugal)
2016/11/18 Induced pluripotent and neural stem cells derived from Huntington´s disease patient exhibit mitochondrial and metabolic abnormalities BRAIN WITHOUT BORDERS - modelling, disease and repair
Portuguese Society for Stem Cells and Cell Therapies (Coimbra, Portugal)
2016 Evaluation of m.7486G>A pathogenicity using a functional genomics 12º International Symposium
Sociedade Portuguesa de Doenças Metabólicas (Coimbra, Portugal)
2016 Still mitochondrial dysfunction in Leber's Hereditary Optic Neuropathy pathogenesis XII Simpósio Internacional da Sociedade Portuguesa De Doenças Metabólicas
Sociedade Portuguesa De Doenças Metabólicas (Coimbra, Portugal)
2015/10/15 Induced pluripotent stem and neural stem cells derived from Huntington´s disease patients unravel early mitochondrial dysfunction and metabolic disturbances 9th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies
Portuguese Society for Stem Cells and Cell Therapies (Oeiras, Portugal)
2015 Functional genomics analysis to gathering evidences for m.8476G>A mutation pathogenicity XIII Annual Meeting from center for neuroscience and cell biology
center for neuroscience and cell biology (coimbra, Portugal)
2015 Induced pluripotent stem and neural stem cells derived from Huntington´s disease patients unravel early mitochondrial dysfunction and metabolic disturbances 9º Encontro Internacional da SPCE-CT
SPCE-CT (Oeiras)
2015 Functional genomics analysis to gathering evidence for m.7486G>A mutation pathogenicity XIII CNC Annual Meeting
Centro de Neurociências de Coimbra (Coimbra, Portugal)
2013 IGF-1 intranasal administration rescues Huntington’s Disease phenotypes in YAC128 mice CNC Annual Meeting
Center for Neuroscience and Cell Biology (Coimbra, Portugal)
2012 Peripheral and cerebral metabolic features in an animal model of Huntington’s disease 2nd Portuguese BioEngineering Meeting
IEEE (Coimbra)
2010 Peripheral and cerebral metabolic features in an animal model of Huntington’s disease expressing full-length mutant huntingtin 4ª Reunião do GEECD
GEECD (Tomar)
2009 Obstructive sleep apnea syndrome and nonarteritic anterior ischemic optic neuropathy ERS Annual Congress
European Respiratory Society (Viena)
2009 Anterior ischemic optic neuropathy and sleep apnea syndrome LII Portuguese Congress of Ophthalmology
Portuguese Society of Ophthalmology (Vilamoura, Portugal)

Orientação

Título / Tema
Papel desempenhado
Curso (Tipo)
Instituição / Organização
2021/09/01 - 2022/09/30 Role of Mitochondria-Derived Damage-Associated Molecular Patterns associated with extracellular microvesicles in promoting early microglia-mediated pro-inflammatory response in neurodegenerative disorders
Orientador
Engenharia Biomédica (Mestrado)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2022/02/01 - 2022/06 iPSC-derived Human Microglia to study early neuroinflammatory response in amyotrophic lateral sclerosis (ALS)
Orientador
Engenharia Biomédica (Licenciatura/Bacharelato)
Universidade de Coimbra Departamento de Física, Portugal
2019 - 2019 Mitochondrial characterization in Huntington´s Disease fibroblasts and iPSC-derived cells
Orientador
Engenharia Biomédica (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2016/09 - 2017/07 Transcriptional and redox changes in Huntington's disease human stem cells
Coorientador
Master in Molecular and Cell Biology (Mestrado)
Universidade de Aveiro, Portugal
2016 - 2016 Exploring alterations in metabolism and mitochondrial dynamics in stem cell models of Huntington's Disease
Orientador
Neurasmus (Mestrado)
Centro de Neurociencias e Biologia Celular, Portugal

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação)
Instituição / Organização
2024/02/07 - Atual Organization of activity at the sixth edition of UC Science Week "The genetic of ageing" https://www.uc.pt/site/assets/files/1220679/cartaz-6_edicao_semana_da_ciencia_uc.png (2024/02/07)
Oficina (workshop)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2023/09/29 - Atual Organize an activity at the European Researchers' Night "Bringing the Matrix to Life! The body-computer interfaces" at the downtown of Coimbra, interacting directly with the population and the citizens of Coimbra. (2023/09/29)
Festival
Universidade de Coimbra, Portugal
2022/09/30 - Atual Organize an activity at the European Researchers' Night "Bringing the Matrix to Life! The body-computer interfaces" at the downtown of Coimbra, interacting directly with the population and the citizens of Coimbra. (2022/09/30)
Festival (Coorganizador)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2024/04/07 - 2024/04/07 Meet.Lab Coimbra is an event organised by the Biology Students' Group of the Coimbra Academic Association, with a strong laboratory component. https://www.instagram.com/_meet.lab_/. I will participate with an workshop on stem cells. (2024/04/07)
Oficina (workshop) (Coorganizador)
Universidade de Coimbra, Portugal
2022/07/01 - 2022/08/12 Organization of a summer internship in the laboratory for two Biomedical Engineering students in collaboration with ANEEB - Associação Nacional de Estudantes de Engenharia Biomédica. (2022 - 2022)
Outro
Centro de Neurociencias e Biologia Celular, Portugal
2022/06/27 - 2022/07/01 Organization of a summer internship in the laboratory for two high school students in collaboration with the "Ciência Viva no Laboratório -Ocupação Científica de Jovens nas Férias". The internship aimed to encourage the students to explore the "stem cell world" https://www.cienciaviva.pt/ciencia-viva-no-laboratorio/estagios/2022/ 1775. À DESCOBERTA DAS CÉLULAS ESTAMINAIS. (2022/06/27 - 2022/07/01)
Outro (Coorganizador)
Ciência Viva, Portugal
2020/08 - 2020/10 “Curso de Verão da UC "Metodologias de Investigação Científica" - Módulo de I&D "Metodologias Avançadas para o Estudo do Cérebro" (2020/08 - 2020/10)
Oficina (workshop) (Coorganizador)
Universidade de Coimbra, Portugal
2016/05 - 2016/05 Synaptosomes as a model of presynaptic dysfunction in brain pathologies - the role of mitochondria Workshop for Biology students (2016/05 - 2016/05)
Oficina (workshop) (Coorganizador)
XIX Encontro Nacional de Estudantes de Biologia, Portugal
2012/12/19 - 2012/12/20 Participation on the organizing committee of the X Center for Neuroscience and Cell Biology Annual Meeting (2012/12/19 - 2012/12/20)
Congresso (Coorganizador)
Centro de Neurociencias e Biologia Celular, Portugal
2012 - 2012 Session about Drug Abuse and Addiction in High School included in the program "Ciência Viva"¿ (2012 - 2012)
Seminário (Outra)
Centro de Neurociencias e Biologia Celular, Portugal

Participação em evento

Descrição da atividade
Tipo de evento
Nome do evento
Instituição / Organização
2023/05/31 - Atual The Pint of Science Festival aims to deliver exciting and relevant talks on the latest scientific research in an accessible format to the public mainly across bars, pubs, cafes, and other public spaces. I participate as a speaker talking about stem cells "Células estaminais ao poder!". https://www.pintofscience.pt/coimbra-31-cabecinhapensadora
Festival
PINT OF SCIENCE PORTUGAL
Pint of Science , Reino Unido
2022/12/14 - Atual Participation at the UC Science Week at "Escola Secundária Afonso Lopes Vieira", Leiria with hands-on activities. https://www.uc.pt/fctuc/dcv/outros-cursos/formacao-em-literacia-cientifica-semana-da-ciencia-uc/2-edicao/
Oficina (workshop)
UC Science Week
Universidade de Coimbra, Portugal
2022/05/19 - Atual Participation at the UC Science Week 2022 at "Escola Secundária Adolfo Portela, em Águeda." https://www.uc.pt/fctuc/dcv/outros-cursos/formacao-em-literacia-cientifica-semana-da-ciencia-uc/1-edicao/#7
Oficina (workshop)
Semana da Ciência UC 2022
Universidade de Coimbra, Portugal
2022/03/25 - Atual Brain Awareness Week - Lecture and hand-on activities in middle school "Infanta D. Maria" in Coimbra.
Seminário
Brain Awareness Week
Centro de Neurociencias e Biologia Celular, Portugal
2021/10/13 - Atual Stem Cell Awareness Day 2021 - Lectures in two middle schools for approximately 100 students.
Seminário
Stem Cell Awareness Day 2021
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2019/11/26 - Atual Science and Technology Week. The Public Outreach Programme developed by CNC offers opportunities to develop partnerships with schools and to extend our scientific resources to the community.
Oficina (workshop)
Science and Technology Week 2019
Centro de Neurociencias e Biologia Celular, Portugal
2014 - Atual Participation at Brain Awareness Week (BAW) with a session "Neuroscientists go to school" at an Elementary School
Seminário
Brain Awareness Week
Centro de Neurociencias e Biologia Celular, Portugal
2022/03/03 - 2022/03/03 Webinar - NRF2 and Cancer “Bench to Bedside transition for Pharmacological regulation of NRF2 in non communicable diseases”
Seminário
Organized in cooperation with the COST action CA20121
Universidad Autónoma de Madrid, Espanha

Faculty of Pharmacy and Medicine, Sapienza University of Rome, Itália
2021/10/28 - 2021/10/29 EMBO WORKSHOP "Microglia 2021" - This workshop highlighted the many important functions of microglia to nervous system physiology and function, the newest and most exciting literature and brought together researchers using state-of-the-art imaging, genomics and molecular biology to study these enigmatic cells.
Oficina (workshop)
Microglia 2021
European Molecular Biology Laboratory, França
2021/10/04 - 2021/10/06 "THE SYNAPTIC DIMENSION OF BRAIN DISORDERS" - The synapse is the fundamental information-processing unit of the brain, and has recently been shown to lie at the root of a wide range of brain disorders. The purpose of this workshop is to present the most relevant and recent advances in the study of synaptic dysfunction in the context of brain disorders. In this workshop we aim to bring together leading scientists in the growing field of synaptopathies, to hear about their latest discoveries.
Oficina (workshop)
THE SYNAPTIC DIMENSION OF BRAIN DISORDERS
Universidad Internacional de Andalucía, Espanha
2021/03/22 - 2021/03/26 During Brain Awareness Week (BAW), a global campaign to increase public awareness of the progress and benefits of brain research, several events are organized by CNC. I gave a lecture on brain-related subjects to 100 high school students from Escola Secundária da Mealhada.
Conferência
Brain Awareness Week
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2020/04/01 - 2020/05/01 Volunteer as part of COVID-19 UC Lab
Outro
Universidade de Coimbra, Portugal
2017 - 2019 Brain Awareness Week Several actions take place for school-age children and the general public. During the action "Neuroscientists go to Schools" neuroscientists visit schools from the region and give lectures on brain-related subjects to high school students; elementary and middle school students perform hands-on activities also on brain-related subjects. During the action "Open Laboratories" students visit CNC laboratories and take part in talks about neuroscience research.
Oficina (workshop)
Brain Awareness Week
Centro de Neurociencias e Biologia Celular, Portugal
2018/11/19 - 2018/11/23 Science and Technology Week 2018 The Public Outreach Programme developed by CNC offers opportunities to develop partnerships with schools and to extend our scientific resources to the community
Outro
Science and Technology Week 2018
Centro de Neurociencias e Biologia Celular, Portugal
2018 - 2018 Participation with microscopy cell images on the science photography exhibition "The Beauty in our Cells" organized by Exploratório /Centro Ciência Viva Coimbra in collaboration with Center for Neuroscience and Cell Biology, Coimbra.
Exposição
Projects in collaboration with the Science Center Exploratório Infante D. Henrique
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2017 - 2017 Science and Technology Week 2017 The Public Outreach Programme developed by CNC offers opportunities to develop partnerships with schools and to extend our scientific resources to the community.
Outro
Science and Technology Week 2017
Centro de Neurociencias e Biologia Celular, Portugal
2017 - 2017 Collaboration in the writing of a comic about neuroscience published at Journal Público during the Brain Awareness Week
Outro
Brain Awareness Week
Centro de Neurociencias e Biologia Celular, Portugal
2017 - 2017 Collaboration at European Researchers' Night at hands-on experiments, more specific activities involving the ulnar nerve stimulation and related muscle activation for the general population.
Exposição
European Researchers' Night 2017
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Júri de grau académico

Tema
Tipo de participação
Nome do candidato (Tipo de grau)
Instituição / Organização
2022/10/13 Associated Molecular Patterns associated to extracellular microvesicles in promoting early microglia-mediated pro-inflammatory response in neurodegenerative disorders
Arguente
Henrique Rafael Freitas Tavares (Mestrado)
Universidade de Coimbra, Portugal
2022/07/14 Relação do silenciamento das proteínas TRAP1 e da p66Shc no contexto do cancro do pulmão e sobrevivência celular ao meio Iscove.
Arguente principal
Juliana Maria Pereira Azevedo (Outro)
Instituto Politécnico de Coimbra Escola Superior Agrária de Coimbra, Portugal
2019 Patient-specific iPSC-derived NESC for Machado-Joseph Disease treatment
Arguente principal
Vanessa Alexandra Castanheira Fernandes (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Arbitragem científica em conferência

Nome da conferência Local da conferência
2024/09/26 - 2024/09/27 First Conference on Targeting Extracellular Vesicles World Mitochondria Society

Arbitragem científica em revista

Nome da revista (ISSN) Editora
2021/12/10 - Atual Frontiers in Aging Neuroscience (16634365) Frontiers Media S.A.
2021/12/10 - Atual Cells (2073-4409) MDPI
2021/11/06 - Atual Communicative & Integrative Biology (1942-0889) Taylor & Francis
2021/09 - Atual BBA Advances (2667-1603) Elsevier
2021/09 - Atual Cells (2073-4409) MDPI
2021/08 - Atual JoVE ( 1940-087X) Jove Books
2021/07/30 - Atual Brain Sciences (2076-3425) MDPI
2021/06 - Atual Biomedicines MDPI
2021/06 - Atual BIOCELL (1667-5746) Tech Science Press
2021/05 - Atual European Journal of Clinical Investigation (1365-2362) Wiley Online Library
2016/03/01 - 2016/04/30 Gene Expression Patterns elsevier

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2024/03/06 - Atual Lecturer of the class "Cancer-associated neurons" at the Master in Cellular and Molecular Biology in the unit "Molecular Biology of Cancer" (Mestrado) Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
2022/03/14 - Atual Lecturer/ Practical classes at the Master in Cellular and Molecular Biology at the unit "Molecular Biology of Cancer" Master in Cellular and Molecular Biology (Curso de mestrado (conclusão do curso de especialização)) Universidade de Coimbra, Portugal
2022/03/09 - Atual Lecture on the topic "Mitochondrial-derived Vesicles as Cellular Stress Responses" integrated into the course "ONE HEALTH and the Metabolism-Disease-Environment Triangle: When Biomedicine meets Innovation, Science Outreach and Social Sciences" of the Doctoral Program in Experimental Biology and Biomedicine (PDBEB) - CNC, University of Coimbra, Coimbra, Portugal. PDBEB Courses 2021/2022 (Doutoramento) Centro de Neurociencias e Biologia Celular, Portugal
2023/03/15 - 2033/03/15 Lecturer of the class "Cancer-associated neurons" at the Master in Cellular and Molecular Biology in the unit "Molecular Biology of Cancer" Master (Mestrado) Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2019/02 - 2019/07 Investigação Aplicada II Medicina (Mestrado integrado) Universidade de Coimbra Faculdade de Medicina, Portugal
2018/03 - 2018/07 Pathology II Fisiologia Clínica (Licenciatura) Instituto Politécnico de Castelo Branco Escola Superior de Saúde Dr Lopes Dias, Portugal
2017/09 - 2018/02 Pathology I Fisiologia Clínica (Licenciatura) Instituto Politécnico de Castelo Branco Escola Superior de Saúde Dr Lopes Dias, Portugal
2016 - 2016 Can iPSC help to decipher the metabolic alterations found in HD? Extensão e divulgação científica (Curso médio) Neurobiologia II, MESTRADO INTEGRADO EM ENGENHARIA BIOMÉDICA, Portugal
2007/02 - 2011/07 Lecturer of Sleep Pathology Fisiologia Clínica (Licenciatura) Instituto Politécnico de Coimbra Escola Superior de Tecnologia da Saúde de Coimbra, Portugal

Membro de associação

Nome da associação Tipo de participação
2023/11/01 - Atual Portuguese Network on Extracellular Vesicles (PNEV) Member
2023/09/01 - Atual International Society for Extracellular Vesicles Senior member
2023/09/01 - Atual ISEV Special Interest Groups "Extracellular Vesicles in the Nervous System" Member
2019/05 - Atual The European Society for Clinical Investigation Member
2017/12/14 - Atual European Huntington's Disease Network Member
2015/03/05 - Atual Portuguese Society for Neuroscience Member
2015/02 - 2022/02 International Society for Stem Cell Research Member

Outro júri / avaliação

Descrição da atividade Instituição / Organização
2021/08/12 - Atual Jury in the international call for a Laboratory Technician (Master degree) post with the reference CTM - 29621. Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2023/06 - 2023/06 Jury member Universidade de Coimbra, Portugal
2021/09 - 2021/10 Jury in the international call for a doctoral post with the reference number 29621.08.2021 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2021/02 - 2021/02 Jury in the international call for a doctoral post with the reference number INV JR 2020. nº 029621. Centro de Neurociencias e Biologia Celular, Portugal
2019/08 - 2019/08 Jury in the international call for a doctoral post with the reference number INV JR 2019. 49 nº 029621. Centro de Neurociencias e Biologia Celular, Portugal
2018/07 - 2018/07 Jury in the call for a Master Research Fellowship with the reference “BIM/ACREGO”. Centro de Neurociencias e Biologia Celular, Portugal

Revisão ad hoc de artigos em revista

Nome da revista (ISSN) Editora
2023/08 - Atual Science Advances (2375-2548) American Association for the Advancement of Science
2023/06/17 - Atual Communications Biology ( 2399-3642) Springer Nature
2022/10 - Atual Cells (2073-4409) MDPI
2022/07/06 - Atual Pharmaceuticals (1424-8247) MDPI
2022/03/15 - Atual International Journal of Molecular Sciences (1422-0067) MDPI
2022/01/29 - Atual Scientific Reports (2045-2322 ) Springer Nature
2021/06 - Atual Journal of Integrative Neuroscience (1757-448X) IMR PRESS

Tutoria

Tópico Nome do aluno
2024/01/29 - 2024/02/23 LABORATORY ROTATIONS in Master's degree in Cellular and Molecular Biology Guilherme Rolo
2023/12/04 - 2023/12/22 LABORATORY ROTATIONS in DOCTORAL PROGRAM IN EXPERIMENTAL BIOLOGY AND BIOMEDICINE Archana Raghunathan
2023/12/11 - 2023/12/15 LABORATORY ROTATIONS in DOCTORAL PROGRAM IN EXPERIMENTAL BIOLOGY AND BIOMEDICINE Filipa Gaspar do Espírito Santo Martins da Silva
2020/08 - 2020/10 Verão Com Ciência, atribuído pela Fundação para a Ciência e a Tecnologia. Maria Brigída
2018/09 - 2019/06 Supervision of a secondary school student Hugo Coimbra
2019/01/28 - 2019/02/28 Master's degree in Cellular and Molecular Biology Catarina Vinhas
2018/10 - 2019/01 International student exchange Bruno Macedo Pinto
2018/09/03 - 2018/09/07 Ciência Viva at the Laboratory Hugo Coimbra; Inês Ferreira
2018/05/07 - 2018/06/01 Master's degree in Cellular and Molecular Biology Marlene Domingues
2016/02 - 2016/07 Neurasmus Sahana Srinivasan
2016/05 - 2016/05 Master in Molecular and Cell Biology Nuno Piedade
2016/02/03 - 2016/03/02 Program Research Exchange José Vitor Magalhães Cardoso
Distinções

Prémio

2022 2022 ESCI Bio Art Award
European Society for Clinical Investigation, Países Baixos
2021 Poster Prize at ESCI's 55TH Virtual ASM
European Society for Clinical Investigation, Países Baixos
2021 Funding EMBO Workshop
European Molecular Biology Laboratory, França
2020 Best Short Presentation at ESCI 2020 Virtual Meeting
European Society for Clinical Investigation, Países Baixos
2019 Best oral communication of basic science at SPDM
Sociedade portuguesa de Doenças do Movimento, Portugal
2019 ESCI Bio Art Award
The European Society for Clinical Investigation , Países Baixos
2017 ISSCR Travel Award
International Society for Stem Cell Research, Estados Unidos
2015 Best poster selected for oral presentation
Portuguese Society for Stem Cells and Cell Therapies, Portugal
2014 Best scientific photo
Centro de Neurociencias e Biologia Celular, Portugal
2012 Best master thesis
2nd Portuguese BioEngineering Meeting, Portugal

Outra distinção

2015 Team member of the winning project submitted to FLAD LIFE SCIENCE 2020
Fundação Luso-Americana, Portugal