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Since 2009, when she became an independent researcher, Alexandra R Fernandes has been involved in two main areas: Diagnostics and Therapy. Her research has been focusing: 1) development of novel diagnostic tools for the genetic diagnostics of cardiomyopathies. In the context of this area of research, she has been involved in several national and international collaborations. This research work has been translated to a diagnostic company HEARTGENETICS SA, where she was a co-founder (2013) and COO (between 2013-2015). 2) The application/validation of novel cancer diagnostics tools in clinical samples. Part of this research has been translated to Nano4 Global Lda, where she was a co-founder (2015) and presently COO. 3) The identification of new promising compounds for cancer therapy, in the characterization of their biological targets and their target delivery to cancer cells. She has been also interested in the identification of markers of resistance to cancer therapy (mostly in chronic myelogenous leukemia and breast cancer). To accomplish these goals, she has been using 2D/3D models of tumor cell lines, primary cultures of cancer patients, blood samples and more recently also in vivo studies using eggs embryos, zebrafish and mice. In the context of this area of research, she has been involved in several national and international collaborations and projects (>25). She has also been using the dog as a model organism for the study of canine mammary tumors. Unlike the man, dog does not respond to common therapy and surgery is the only resource. The current understanding of breast cancer women's help in identifying the biological mechanisms underlying this canine mammary tumors and new knowledge that will come from here can shed some light for new therapeutics. The aim is to study the proteome and the transcriptome of canine mammary tumors with different morphologies and stages to identify new fusion products, new mutations or miRNAs involved in tumor progression. The creation of a database of primary cultures and tissues is also an objective of this research. She developed a new cell line that has been licensed to Applied Biological Materials (ABM) Inc (https://www.abmgood.com/FR37-CMT-Tumor-Cells-T8002.html). She has been involved in Expert Evaluation of International R&D Projects and Grants (Austrian Science Fund I projects; ANR - Agence Nationale de la Researche; Czech Science Foundation, UK Welcome Trust, FCT/MCTES). Since 2009 she has been involved in several national and International funded Research Projects (5 has Principal Investigator (two International, three National) and 22 as Team member (three European, 19 National)). She has experience as a scientific adviser (Post-Doc Supervision: 4 (since 2013); PhD Supervision: 10 (since 2011); PhD Jury member in 10 PhD National Thesis and 3 PhD International Thesis; Master Supervision: 40 (since 2010); Master Jury: 81; Graduation Thesis Supervision: 60; Graduation Thesis Jury: >120; Erasmus - Post-Doc: 2; PhD students: 4; Master students: 1; graduation students: 7. She has published 10 book chapters, >150 papers in International Journals with referees, 3 papers in Proceedings of International Conferences (with referees), 3 papers in National Journals with referees. She has > 48 oral communications in International and National Meetings (with referees) and more than 100 communications in Panel.
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Identificação

Identificação pessoal

Nome completo
Alexandra R Fernandes

Nomes de citação

  • Fernandes, Alexandra
  • Alexandra R Fernandes

Identificadores de autor

Ciência ID
021D-7DC8-C92F
ORCID iD
0000-0003-2054-4438
Google Scholar ID
https://scholar.google.pt/citations?user=7ZUgRWAAAAAJ&hl=pt-PT
Researcher Id
C-7465-2011
Scopus Author Id
7201782186

Endereços de correio eletrónico

  • ma.fernandes@fct.unl.pt (Profissional)

Telefones

Telefone
  • 212948530 (Profissional)

Moradas

  • Departamento Ciências da Vida, FCT-UNL. Caparica, 2829-516, Caparica, Almada, Portugal (Profissional)

Websites

Domínios de atuação

  • Ciências Médicas e da Saúde - Biotecnologia Médica - Diagnóstico e Terapias de Base Genética
  • Ciências Médicas e da Saúde - Biotecnologia Médica - Biotecnologia Aplicada à Saúde
  • Ciências Médicas e da Saúde - Medicina Básica - Genética Humana

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Francês Utilizador independente (B1) Utilizador independente (B1) Utilizador independente (B1) Utilizador independente (B1)
Alemão Utilizador elementar (A1) Utilizador elementar (A1) Utilizador elementar (A1) Utilizador elementar (A1)
Formação
Grau Classificação
2000/04/18
Concluído
 Biotecnology (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
"A H+-ATPase da membrana plasmática e a resposta ao stress oxidativo, em particular ao stress pelo cobre, em Saccharomyces cerevisiae" (TESE/DISSERTAÇÃO)
 Aproved
1995/09/01
Concluído
 Engenharia Bioquímica (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
"n/a" (TESE/DISSERTAÇÃO)
 Parte escolar - 17 valores
1994/09/05
Concluído
 Engenharia Química (Ramo Biotecnologia) (Licenciatura)
Universidade de Lisboa Instituto Superior Técnico, Portugal
"n/a" (TESE/DISSERTAÇÃO)
 15 valores
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2015/01/01 - Atual Investigador principal (carreira) (Investigação) REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
2015/01/01 - 2015 Investigador (Investigação) Universidade de Lisboa Centro de Química Estrutural, Portugal
2008/12/01 - 2014/12/31 Investigador (Investigação) Universidade de Lisboa Instituto Superior Técnico, Portugal
2009 - 2013 Investigador (Investigação) Universidade de Lisboa Centro de Química Estrutural, Portugal
2006 - 2008 Investigador (Investigação) Universidade de Lisboa, Portugal

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2013/03/01 - Atual Professor Auxiliar (Docente Universitário) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2016 - 2018 Professor Auxiliar (Docente Universitário) Universidade Nova de Lisboa, Portugal
2013 - 2016 Professor Auxiliar (Docente Universitário) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2010/10/01 - 2013/02/28 Professor Associado (Docente Universitário) Universidade Lusófona de Humanidades e Tecnologias, Portugal
2009/04/01 - 2013/02/28 Assistente Convidado (Docente Universitário) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2000/04/20 - 2010/09/30 Professor Auxiliar (Docente Universitário) Universidade Lusófona de Humanidades e Tecnologias, Portugal
1998/04/20 - 2000/03/31 Assistente (Docente Universitário) Universidade Lusófona de Humanidades e Tecnologias, Portugal

Cargos e Funções

Categoria Profissional
Instituição de acolhimento 		Empregador
2021/05/01 - Atual Coordenador Mestrado em Genética Molecular e Biomedicina Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2015/12/14 - Atual Founder of Nano4Global. Lda Nano4 Global Lda, Portugal
2013/04/01 - 2015/09/30 Founder of Heartgenetics SA Shareholder of Heartgenetics HeartGenetics Genetics and Biotechnology SA, Portugal
2010/06/01 - 2013/03/01 Coordinator of the Master in Cancer Biology Universidade Lusófona de Humanidades e Tecnologias, Portugal
2009/10/01 - 2013/03/01 Coordinator of the Master in Biotechnology Engineering Universidade Lusófona de Humanidades e Tecnologias, Portugal
2010/09/01 - 2011/08/31 Invited assistant Professor (Coordinator of the Molecular Biotechnology Module in the Life Sciences PhD Program) Universidade do Porto, Portugal
2009/05/01 - 2011/05/12 Advisor of the Genetic and Cellular Biology Group of the Portuguese Society of Cardiology Sociedade Portuguesa de Cardiologia, Portugal
2009/10/01 - 2010/12/31 Coordinator of the Master in Development Biology Universidade Lusófona de Humanidades e Tecnologias, Portugal
2009/03/01 - 2010/09/30 Coordinator of the "Pós-Graduação Genética Clinica e Laboratorial" Universidade Lusófona de Humanidades e Tecnologias, Portugal
2005/09/01 - 2008/03/31 Molecular Biology Laboratory Director Centro de Genética Clínica e Patologia SA, Portugal
2000 - 2005 Pos-doc research Universidade de Lisboa Instituto Superior Técnico, Portugal
Projetos

Projeto

Designação Financiadores
2021/03/29 - 2024/03/28 Derivados de triptofanol para reativação de formas mutadas da p53 <br>
PTDC/QUI-QOR/1304/2020
Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal

Associação para a Inovação e Desenvolvimento da FCT, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2021/03/01 - 2024/02/29 Fármacos de ruténio-péptido: flechas para alvejar seletivamente o cancro da mama
PTDC/QUI-QIN/0146/2020
Universidade de Lisboa Centro de Química Estrutural, Portugal

Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal

Associação para a Inovação e Desenvolvimento da FCT, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2018/08/01 - 2022/07/31 Nanomateriais Auto-Organizados Para Entrega Fotocontrolada de Fármacos e Genes
PTDC/QUI-COL/32351/2017
Associação para a Inovação e Desenvolvimento da FCT, Portugal

Universidade do Porto, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2019/02/01 - 2022/01/31 Valorização de Moléculas Isoladas de Anfíbios Aquáticos Portugueses
PTDC/BII-BIO/31158/2017
Investigador
Instituto de Biologia Molecular e Celular, Portugal

Associação para a Inovação e Desenvolvimento da FCT, Portugal

REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
Fundação para a Ciência e a Tecnologia

Governo da República Portuguesa Ministério da Ciência Tecnologia e Ensino Superior
Em curso
2019/01/31 - 2022/01/01 Quimica macrocíclica y organometálica – QUIMIOR.
1. CONSOLIDACIÓN 2019 GRC GI-1581
Investigador
REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal

Universidade de Santiago de Compostela Facultade de Química, Espanha
Em curso
2019/01/01 - 2022/01/01 Synthesis of Heterocyclic Compounds for biological and technological applications
2. FAPESP:2018/00544-4
Investigador
REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal

Fundação de Amparo à Pesquisa do Estado de São Paulo, Brasil
Em curso
2020/06 - 2021/12/31 ACTPHAST
ACTPHAST: Innovation Project Proposal project ID P2019 -36
ACTPHAST: Innovation Project Proposal project ID P2019 -36
Investigador
Nano4 Global Lda, Portugal
 N/A
Concluído
2018/07/01 - 2021/12/31 SME Phase II
SME Phase II
Investigador responsável
Nano4 Global Lda, Portugal
 Conseil de l'Union Europeenne
Concluído
2018/10/01 - 2021/09/30 Plataforma de Microfluidica Integrada para a deteção do cancro através de PCR digital de ADN livre circulante
PTDC/BTM-SAL/31201/2017
PTDC/BTM/SAL/31201/2017
Investigador
Associação para a Inovação e Desenvolvimento da FCT, Portugal

REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
Fundação para a Ciência e a Tecnologia

Governo da República Portuguesa Ministério da Ciência Tecnologia e Ensino Superior
Em curso
2018/09/01 - 2021/01/31 EraNet MAGICCELLGene: Localized MAGnetIC hyperthermia CELL-based GENE therapy for immune modulation.
EraNet MAGICCELLGene/2015
Investigador
REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
 Conseil de l'Union Europeenne
Em curso
2019 - 2021 Detecção e Caracterização de Nanopartículas Usando Nanoporos de Estado Sólido: Uma Abordagem Única Molécula
PTDC/NAN/MAT/31100/2017
PTDC/NAN-MAT/31100/2017
Investigador
REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal

Universidade Nova de Lisboa, Portugal

Associação para a Inovação e Desenvolvimento da FCT, Portugal
Governo da República Portuguesa Ministério da Ciência Tecnologia e Ensino Superior

Conseil de l'Union Europeenne

Fundação para a Ciência e a Tecnologia
Em curso
2019 - 2021 Marine invertebrates as source of novel biotoxins: Investigating function and application through Polychaeta venomics
PTDC/BTA/28650/2017
Investigador
REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
 Governo da República Portuguesa Ministério da Ciência Tecnologia e Ensino Superior
Em curso
2019 - 2021 Novel photoinduced-molecules for cancer therapy
PTDC/QUI/CCL/032351/2017
Investigador
REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
 Governo da República Portuguesa Ministério da Ciência Tecnologia e Ensino Superior
2019 - 2021 The MARVEN Project -The Portuguese biotechnological database for marine animal venoms and toxins
FA_05_2017_007
Investigador
REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
 Fundo Azul
Em curso
2019 - 2021 Ionic liquids as a new platform for tuberculosis treatment (TB-ILs)
PTDC/QUI/QER/32406/2017
PTDC/QUI/QER/32406/2017
Investigador
REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
 Governo da República Portuguesa Ministério da Ciência Tecnologia e Ensino Superior
Em curso
2020/01/06 - 2020/06/01 Quick COVID-19 Detection (QuiCoviDe)
RESEARCH4COVID19/2020
Investigador
REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
Concluído
2016/04/01 - 2020/03/30 RA DETECT - One Platform – multiple biomarker detection of Rheumatoid Arthritis
Era-Net - Inno Indigo 2015
Investigador
REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
 European Commission
Concluído
2016/07/03 - 2019/12/31 De pigmentos e toxinas: uma abordagem integradora ao potencial biotecnológico de um poliqueta marinho
PTDC/MAR-BIO/0113/2014
Investigador
Associação para a Inovação e Desenvolvimento da FCT, Portugal

Centro de Ciências do Mar e do Ambiente, Portugal

Egas Moniz Cooperativa de Ensino Superior CRL, Portugal

REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
Fundação para a Ciência e a Tecnologia

Koeki Zaidan Hojin Nakayama Hayao Kagaku Gijutsu Bunka Zaidan
Concluído
2016/05/02 - 2019/11/01 Avaliação da especificidade do hospedeiro e das interacções agente patogénico-hospedeiro em Streptococcus
PTDC/CVT-EPI/6685/2014
Investigador
Associação para a Inovação e Desenvolvimento da FCT, Portugal

REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
Fundação para a Ciência e a Tecnologia

Koeki Zaidan Hojin Nakayama Hayao Kagaku Gijutsu Bunka Zaidan
Concluído
2015/01/01 - 2018/01/01 Cytotoxicity and photo-cytotoxicity of nitrosyl ruthenium anticancer drug in aqueous solution or incorporated in a drug delivery system. An innovative purpose for metal based drug
2015/50101-3
Investigador responsável
REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
 Conselho Nacional de Desenvolvimento Científico e Tecnológico
Concluído
2017/06 - 2017/12 SME Phase I
SME Phase I
Investigador responsável
Nano4 Global Lda, Portugal
Concluído
2016/01/01 - 2017/01/01 Validation of Natural extracts for dermal applications
Vitrobio
Investigador responsável
REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
Concluído
2013/06/01 - 2016/12/31 De pequenas moléculas bioactivas a uma abordagem ÓMICA integrada: Ferramentas de Espectrometria de Massa para a compreensão mecanística de propriedades farmacológicas e funcionais, toxicidade e respostas ao stress
RECI/QEQ-MED/0330/2012
Investigador
Universidade de Lisboa Centro de Química Estrutural, Portugal

Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal

Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

Centro Hospitalar de Lisboa Central EPE, Portugal

Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal

Hospital Professor Doutor Fernando Fonseca EPE, Portugal
Fundação para a Ciência e a Tecnologia

Fundação para a Ciência e a Tecnologia, I.P.
Concluído
2013/01/01 - 2016/03/01 Silence is golden (siAu) - silencing the silencers via multifunctional gold nanoconjugates towards cancer therapy
PTDC/BBB-NAN/1812/2012
Investigador
Universidade de Lisboa Centro de Química Estrutural, Portugal

REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal

Universidade Nova de Lisboa Centro de Toxicogenómica e Saúde Humana, Portugal

Associação para a Inovação e Desenvolvimento da FCT, Portugal
Fundação para a Ciência e a Tecnologia, I.P.

Fundação para a Ciência e a Tecnologia
Concluído
2013/01/01 - 2016/01/01 Unraveling the host specificity within Streptococcus dysgalactiae subsp. dysgalactiae
PTDC/CVT-EPI/4651/2012
Investigador
Universidade de Lisboa Centro de Química Estrutural, Portugal

REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal

Associação para a Inovação e Desenvolvimento da FCT, Portugal
Fundação para a Ciência e a Tecnologia, I.P.

Fundação para a Ciência e a Tecnologia
Concluído
2015 - 2016 Evaluation of deep-sea animal lipid extracts as new natural anticancer cellular therapy
APCL|FCG 2014
Investigador responsável
REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
 Associação Portuguesa Contra a Leucemia
Concluído
2008/01/01 - 2010/01/01 Imatinib resistance and targets in Chronic Myeloid Leukaemia: post-genomic approaches using yeast as a model system
PTDC/SAU-FCF/71760/2006
Investigador
Centro de Genética Clínica e Patologia SA, Portugal
 Governo da República Portuguesa Ministério da Ciência Tecnologia e Ensino Superior
Concluído
2007/01/01 - 2010/01/01 Mechanisms of resistance to Imatinib in Chronic Myeloid Leukemia
PTDC/SAU-GMG/71720/2006
Investigador
Centro de Genética Clínica e Patologia SA, Portugal

Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
Governo da República Portuguesa Ministério da Ciência Tecnologia e Ensino Superior

Fundação para a Ciência e a Tecnologia
Concluído
2006/01/02 - 2008/01/01 Elucidação das complexas redes de regulação que actuam na levedura sujeita a drogas/stresse químico: abordagens de expressão genómica e de bioinformática
PDCT/BIO/56838/2004
Universidade de Lisboa Instituto Superior Técnico, Portugal

Universidade de Lisboa Instituto Superior Técnico, Portugal

Instituto de Engenharia de Sistemas e Computadores Investigação e Desenvolvimento em Lisboa, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2005/01/01 - 2007/12/31 DBYeast: Infraestruturas e algoritmos para análise e identificação de redes de regulação genética
POSC/EIA/57398/2004
Instituto de Engenharia de Sistemas e Computadores Investigação e Desenvolvimento em Lisboa, Portugal

Universidade de Lisboa Instituto Superior Técnico, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2003/02/01 - 2005 Adaptation and resistance to organic acid food preservatives in yeast
info:eu-repo/grantAgreement/FCT/POCI/45347/PT
Bolseiro de Pós-Doutoramento
Universidade do Algarve Faculdade de Ciências e Tecnologia
Concluído
2002 - 2004 Genomic-oriented studies on Saccharomyces cerevisiae
POCTI/BIO/38115/2001
Bolseiro de Pós-Doutoramento
Concluído
2002 - 2004 Resistência a benomil e outros fungicidas em Saccharomyces cerevisiae: papel de transportadores de múltiplas drogas e sua regulação
POCTI/AGG/38110/2001
Bolseiro de Pós-Doutoramento
Concluído
2001 - 2003 Strategies to accelerate the produtive biodegradation of several herbicides under environmental stress conditions
HERBICBIOREM 2001
Bolseiro de Pós-Doutoramento
European Union
Concluído

Outro

Designação Financiadores
2014/01/01 - 2017/01/01 Gold multifunctional nanoparticles for targeting cancer – Cetuximab
Merck-Serono
Investigador responsável
REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal

Universidade de Lisboa Centro de Química Estrutural, Portugal
Concluído
Produções

Publicações

Artigo em conferência
  1. Catia M Machado; Francisco Couto; Alexandra R Fernandes; Susana Santos; Nuno Cardim; Ana T Freitas; Machado, C.M.; et al. "Semantic characterization of hypertrophic cardiomyopathy disease". 2010.
    10.1109/bibmw.2010.5703841
Artigo em revista
  1. Inês C. B. Martins; Andreia Forte; Hermínio P. Diogo; Luís R. Raposo; Pedro V. Baptista; Alexandra R. Fernandes; Luís C. Branco; M. Teresa Duarte. "A solvent-free strategy to prepare amorphous salts of folic acid with enhanced solubility and cell permeability". Chemistry–Methods (2022): https://doi.org/10.1002/cmtd.202100104.
    10.1002/cmtd.202100104
  2. Margarida Ferreira-Silva; Ana Catarina Faria da Silva; Manuela Carvalheiro; Sandra Simões; H. Susana Marinho; Paulo Marcelino; Maria Celeste Campos; et al. "Quercetin Liposomal Nanoformulation for Ischemia and Reperfusion Injury Treatment". Pharmaceutics (2022): https://www.mdpi.com/1999-4923/14/1/104.
    10.3390/pharmaceutics14010104
  3. Andrea Pinto; Catarina Roma-Rodrigues; Jas S. Ward; Rakesh Puttreddy; Kari Rissanen; Pedro V. Baptista; Alexandra R. Fernandes; João Carlos Lima; Laura Rodríguez. "Aggregation versus Biological Activity in Gold(I) Complexes. An Unexplored Concept". Inorganic Chemistry (2021): https://doi.org/10.1021/acs.inorgchem.1c02359.
    10.1021/acs.inorgchem.1c02359
  4. Bilal Abdulmawjood; Beatriz Costa; Catarina Roma-Rodrigues; Pedro V. Baptista; Alexandra R. Fernandes. "Genetic Biomarkers in Chronic Myeloid Leukemia: What Have We Learned So Far?". International Journal of Molecular Sciences 22 22 (2021): 12516-12516. https://doi.org/10.3390/ijms222212516.
    10.3390/ijms222212516
  5. Ana R. Jesus; Luís R. Raposo; Mário R. C. Soromenho; Daniela A. S. Agostinho; José M. S. S. Esperança; Pedro V. Baptista; Alexandra R. Fernandes; Patrícia M. Reis. "New Non-Toxic N-alkyl Cholinium-Based Ionic Liquids as Excipients to Improve the Solubility of Poorly Water-Soluble Drugs". Symmetry (2021): https://doi.org/10.3390/sym13112053.
    10.3390/sym13112053
  6. Joanna Palion-Gazda; André Luz; Luís R Raposo; Katarzyna Choroba; Jacek Nycz; Alina Bienko; Agnieszka Lewinska; et al. "Vanadium(IV) Complexes with Methyl-Substituted 8-Hydroxyquinolines: Catalytic Potential in the Oxidation of Hydrocarbons and Alcohols with Peroxides and Biological Activity". Molecules (2021): https://www.mdpi.com/1420-3049/26/21/6364.
    10.3390/molecules26216364
  7. Oscar A. Lenis-Rojas; Sandra Cordeiro; Marta Horta-Meireles; Jhonathan Angel Araujo Fernández; Sabela Fernández Vila; Juan Andrés Rubiolo; Pablo Cabezas-Sainz; et al. "N-Heterocyclic Carbene Iron Complexes as Anticancer Agents: In Vitro and In Vivo Biological Studies". Molecules 26 18 (2021): 5535-5535. https://doi.org/10.3390/molecules26185535.
    10.3390/molecules26185535
  8. Oscar Lenis-Rojas; Catarina Roma-Rodrigues; Alexandra Fernandes; Andreia Carvalho; Sandra Cordeiro; Jorge Guerra-Varela; Laura Sánchez; et al. "Evaluation of the In Vitro and In Vivo Efficacy of Ruthenium Polypyridyl Compounds against Breast Cancer". International Journal of Molecular Sciences 22 16 (2021): 8916-8916. https://doi.org/10.3390/ijms22168916.
    10.3390/ijms22168916
  9. Oscar A. Lenis-Rojas; Rui Cabral; Beatriz Carvalho; Sofia Friães; Catarina Roma-Rodrigues; Jhonathan A. A. Fernández; Sabela F. Vila; et al. "Triazole-Based Half-Sandwich Ruthenium(II) Compounds: From In Vitro Antiproliferative Potential to In Vivo Toxicity Evaluation". Inorganic Chemistry 60 11 (2021): 8011-8026. https://doi.org/10.1021/acs.inorgchem.1c00527.
    10.1021/acs.inorgchem.1c00527
  10. Margarida Ferreira-Silva; Catarina Faria-Silva; Pedro Viana Baptista; Eduarda Fernandes; Alexandra Ramos Fernandes; Maria Luísa Corvo. "Drug delivery nanosystems targeted to hepatic ischemia and reperfusion injury". Drug Delivery and Translational Research (2021): https://doi.org/10.1007/s13346-021-00915-8.
    10.1007/s13346-021-00915-8
  11. Margarida Ferreira-Silva; Catarina Faria-Silva; Pedro Viana Baptista; Eduarda Fernandes; Alexandra Ramos Fernandes; Maria Luísa Corvo. "Liposomal Nanosystems in Rheumatoid Arthritis". Pharmaceutics 13 4 (2021): 454-454. https://doi.org/10.3390/pharmaceutics13040454.
    10.3390/pharmaceutics13040454
  12. Francisco Reigosa-Chamorro; Luís R. Raposo; Paula Munín-Cruz; M. Teresa Pereira; Catarina Roma-Rodrigues; Pedro V. Baptista; Alexandra R. Fernandes; José M. Vila. "In Vitro and In Vivo Effect of Palladacycles: Targeting A2780 Ovarian Carcinoma Cells and Modulation of Angiogenesis". Inorganic Chemistry (2021): https://doi.org/10.1021/acs.inorgchem.0c03763.
    10.1021/acs.inorgchem.0c03763
  13. Oscar A. Lenis-Rojas; M. Paula Robalo; Ana Isabel Tomaz; Alexandra R. Fernandes; Catarina Roma-Rodrigues; Ricardo G. Teixeira; Fernanda Marques; et al. "Half-Sandwich Ru(p-cymene) Compounds with Diphosphanes: In Vitro and In Vivo Evaluation As Potential Anticancer Metallodrugs". Inorganic Chemistry (2021): https://doi.org/10.1021/acs.inorgchem.0c02768.
    10.1021/acs.inorgchem.0c02768
  14. Choroba, Katarzyna; Machura, Barbara; Szlapa-Kula, Agata; Malecki, Jan G.; Raposo, Luis; Roma-Rodrigues, Catarina; Cordeiro, Sandra; Baptista, Pedro V.; Fernandes, Alexandra R.. "Square planar Au(III), Pt(II) and Cu(II) complexes with quinoline-substituted 2,2':6',2''-terpyridine ligands: from in vitro to in vivo biological properties". European Journal of Medicinal Chemistry (2021): 113404. http://dx.doi.org/10.1016/j.ejmech.2021.113404.
    10.1016/j.ejmech.2021.113404
  15. José L. Quiles; Catarina Roma-Rodrigues; Luís R Raposo; María D. Navarro-Hortal; Jose M. Romero-Márquez; Adelaida Esteban-Muñoz; Alfonso Varela-López; et al. "Rosa x hybrida extracts with dual actions: Antiproliferative effects against tumour cells and inhibitor of Alzheimer disease". Food and Chemical Toxicology 149 (2021): https://novaresearch.unl.pt/en/publications/1dd08105-b75e-4004-aff7-1afa1ee9e732.
    10.1016/j.fct.2021.112018
  16. Ana P. Rodrigo; Ana R. Grosso; Pedro V. Baptista; Alexandra R. Fernandes; Pedro M. Costa. "A Transcriptomic Approach to the Recruitment of Venom Proteins in a Marine Annelid". Toxins 13 2 (2021): 97-97. https://doi.org/10.3390/toxins13020097.
    10.3390/toxins13020097
  17. Ana P. Rodrigo; Vera M. Mendes; Bruno Manadas; Ana R. Grosso; António P. Alves de Matos; Pedro V. Baptista; Pedro M. Costa; Alexandra R. Fernandes. "Specific Antiproliferative Properties of Proteinaceous Toxin Secretions from the Marine Annelid Eulalia sp. onto Ovarian Cancer Cells". Marine Drugs (2021): https://doi.org/10.3390/md19010031.
    10.3390/md19010031
  18. Luís R. Raposo; Ana Silva; Dário Silva; Catarina Roma-Rodrigues; Margarida Espadinha; Pedro V. Baptista; Maria M.M. Santos; Alexandra R. Fernandes. "Exploiting the antiproliferative potential of spiropyrazoline oxindoles in a human ovarian cancer cell line". Bioorganic & Medicinal Chemistry 30 (2021): 115880-115880. https://doi.org/10.1016/j.bmc.2020.115880.
    10.1016/j.bmc.2020.115880
  19. Pedro Pedrosa; Pedro V. Baptista; Alexandra R. Fernandes; Mauro Guerra. "Benchtop X-ray fluorescence imaging as a tool to study gold nanoparticle penetration in 3D cancer spheroids". RSC Advances (2021): https://doi.org/10.1039/D1RA05446E.
    10.1039/D1RA05446E
  20. Nazanin Kordestani; Hadi Amiri Rudbari; Alexandra R. Fernandes; Luís R. Raposo; André Luz; Pedro V. Baptista; Giuseppe Bruno; et al. "Copper(ii) complexes with tridentate halogen-substituted Schiff base ligands: synthesis, crystal structures and investigating the effect of halogenation, leaving groups and ligand flexibility on antiproliferative activities". Dalton Transactions (2021): https://doi.org/10.1039/D0DT03962D.
    10.1039/D0DT03962D
  21. Diogo Sequeira; Pedro V. Baptista; Ruben Valente; M. Fátima M. Piedade; M. Helena Garcia; Tânia S. Morais; Alexandra R. Fernandes. "Cu(i) complexes as new antiproliferative agents against sensitive and doxorubicin resistant colorectal cancer cells: synthesis, characterization, and mechanisms of action". Dalton Transactions (2021): https://doi.org/10.1039/D0DT03566A.
    10.1039/D0DT03566A
  22. Catarina Roma-Rodrigues; Inês Pombo; Alexandra R. Fernandes; Pedro V. Baptista. "Hyperthermia Induced by Gold Nanoparticles and Visible Light Photothermy Combined with Chemotherapy to Tackle Doxorubicin Sensitive and Resistant Colorectal Tumor 3D Spheroids". International Journal of Molecular Sciences 21 21 (2020): 8017-8017. https://doi.org/10.3390/ijms21218017.
    10.3390/ijms21218017
  23. Lilianne Beola; Laura Asín; Catarina Roma-Rodrigues; Yilian Fernandez-Afonso; Raluca M. Fratila; David Serantes; Sergiu Ruta; et al. "The intracellular number of magnetic nanoparticles modulates the apoptotic death pathway after magnetic hyperthermia treatment". ACS Applied Materials and Interfaces 12 39 (2020): 43474-43487. https://novaresearch.unl.pt/en/publications/58ee5e02-b4e8-4d36-a618-a3d36901a6a7.
    10.1021/acsami.0c12900
  24. Daniela Ferreira; David Fontinha; Catarina Martins; David Pires; Alexandra R. Fernandes; Pedro V. Baptista. "Gold Nanoparticles for Vectorization of Nucleic Acids for Cancer Therapeutics". Molecules (2020): https://doi.org/10.3390/molecules25153489.
    10.3390/molecules25153489
  25. Daniela Alves Ferreira; Luísa M. D. R. S. Martins; Alexandra R. Fernandes; Marta Martins. "A Tale of Two Ends: Repurposing Metallic Compounds from Anti-Tumour Agents to Effective Antibacterial Activity". Antibiotics 9 6 (2020): 321-321. https://doi.org/10.3390/antibiotics9060321.
    10.3390/antibiotics9060321
  26. Rita B. Restani; Rita F. Pires; Pedro V. Baptista; Alexandra R. Fernandes; Teresa Casimiro; Vasco D. B. Bonifácio; Ana Aguiar-Ricardo. "Nano-in-Micro Sildenafil Dry Powder Formulations for the Treatment of Pulmonary Arterial Hypertension Disorders: The Synergic Effect of POxylated Polyurea Dendrimers, PLGA, and Cholesterol". Particle & Particle Systems Characterization (2020): 1900447-1900447. https://doi.org/10.1002/ppsc.201900447.
    10.1002/ppsc.201900447
  27. Beatriz Oliveira; Bruno Veigas; Alexandra R. Fernandes; Hugo Águas; Rodrigo Martins; Elvira Fortunato; Pedro Viana Baptista. "Fast Prototyping Microfluidics: Integrating Droplet Digital Lamp for Absolute Quantification of Cancer Biomarkers". Sensors (2020): https://doi.org/10.3390/s20061624.
    10.3390/s20061624
  28. Roma-Rodrigues, Catarina; Rivas-García, Lorenzo; Baptista, Pedro V.; Fernandes, Alexandra R.. "Gene Therapy in Cancer Treatment: Why Go Nano?". Pharmaceutics 12 3 (2020): 233. http://dx.doi.org/10.3390/pharmaceutics12030233.
    10.3390/pharmaceutics12030233
  29. Nazanin Kordestani; Hadi Amiri Rudbari; Alexandra R. Fernandes; Luís R. Raposo; Pedro V. Baptista; Daniela Ferreira; Giuseppe Bruno; et al. "Antiproliferative Activities of Diimine-Based Mixed Ligand Copper(II) Complexes". ACS Combinatorial Science 22 2 (2020): 89-99. https://doi.org/10.1021/acscombsci.9b00202.
    10.1021/acscombsci.9b00202
  30. Katarzyna Choroba; Luis R. Raposo; Joanna Palion-Gazda; Ewa Malicka; Karol Erfurt; Barbara Machura; Alexandra R. Fernandes. "In vitro antiproliferative effect of vanadium complexes bearing 8-hydroxyquinoline-based ligands – the substituent effect". Dalton Transactions (2020): https://doi.org/10.1039/D0DT01017K.
    10.1039/D0DT01017K
  31. Fernandes, A.R.; Mendonça-Martins, I.; Santos, M.F.A.; Raposo, L.R.; Mendes, R.; Marques, J.; Romão, C.C.; et al. "Improving the Anti-inflammatory Response via Gold Nanoparticle Vectorization of CO-Releasing Molecules". ACS Biomaterials Science and Engineering 6 2 (2020): 1090-1101. http://www.scopus.com/inward/record.url?eid=2-s2.0-85079071744&partnerID=MN8TOARS.
    10.1021/acsbiomaterials.9b01936
  32. Busila, M.; Tabacaru, A.; Mussat, V.; Vasile, B.S.; Neasu, I.A.; Pinheiro, T.; Roma-Rodrigues, C.; et al. "Size-Dependent Biological Activities of Fluorescent Organosilane-Modified Zinc Oxide Nanoparticles". Journal of biomedical nanotechnology 16 2 (2020): 137-152. http://www.scopus.com/inward/record.url?eid=2-s2.0-85083071724&partnerID=MN8TOARS.
    10.1166/jbn.2020.2882
  33. Roma-Rodrigues, C.; Malta, G.; Peixoto, D.; Ferreira, L.M.; Baptista, P.V.; Fernandes, A.R.; Branco, P.S.. "Synthesis of new hetero-arylidene-9(10H)-anthrone derivatives and their biological evaluation". Bioorganic Chemistry 99 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85083360964&partnerID=MN8TOARS.
    10.1016/j.bioorg.2020.103849
  34. João Franco Machado; Diogo Sequeira; Fernanda Marques; M. Fátima M. Piedade; Maria J. Villa de Brito; M. Helena Garcia; Alexandra R. Fernandes; Tânia S. Morais. "New copper(i) complexes selective for prostate cancer cells". Dalton Transactions (2020): https://doi.org/10.1039/D0DT02157A.
    10.1039/D0DT02157A
  35. Pedro Pedrosa; M. Luísa Corvo; Margarida Ferreira-Silva; Pedro Martins; Manuela Colla Carvalheiro; Pedro M. Costa; Carla Martins; et al. "Targeting Cancer Resistance via Multifunctional Gold Nanoparticles". International Journal of Molecular Sciences (2019): https://doi.org/10.3390/ijms20215510.
    10.3390/ijms20215510
  36. Das K; Datta A; Frontera A; Wen YS; Roma-Rodrigues C; Raposo LR; Fernandes AR; Hung CH. "Zn(II) and Co(II) derivatives anchored with scorpionate precursor: Antiproliferative evaluation in human cancer cell lines.". Journal of inorganic biochemistry (2019): http://europepmc.org/abstract/med/31698185.
    10.1016/j.jinorgbio.2019.110881
  37. Catarina Roma-Rodrigues; Alexandra R. Fernandes; Pedro V. Baptista. "

    Counteracting the effect of leukemia exosomes by antiangiogenic gold nanoparticles

    ". International Journal of Nanomedicine (2019): https://doi.org/10.2147/IJN.S215711.
    10.2147/IJN.S215711
  38. Roma-Rodrigues C; Pombo I; Raposo L; Pedrosa P; Fernandes AR; Baptista PV. "Nanotheranostics Targeting the Tumor Microenvironment.". Frontiers in bioengineering and biotechnology (2019): http://europepmc.org/abstract/med/31475143.
    10.3389/fbioe.2019.00197
  39. Almeida J; Roma-Rodrigues C; Mahmoud AG; Guedes da Silva MFC; Pombeiro AJL; Martins LMDRS; Baptista PV; Fernandes AR. "Structural characterization and biological properties of silver(I) tris(pyrazolyl)methane sulfonate.". Journal of inorganic biochemistry (2019): http://europepmc.org/abstract/med/31357066.
    10.1016/j.jinorgbio.2019.110789
  40. Veigas B; Matias A; Calmeiro T; Fortunato E; Fernandes AR; Baptista PV. "Antibody modified gold nanoparticles for fast colorimetric screening of rheumatoid arthritis.". The Analyst (2019): http://europepmc.org/abstract/med/31070614.
    10.1039/c9an00319c
  41. Santos MM; Raposo LR; Carrera GVSM; Costa A; Dionísio M; Baptista PV; Fernandes AR; Branco LC. "Ionic Liquids and Salts from Ibuprofen as Promising Innovative Formulations of an Old Drug.". ChemMedChem (2019): http://europepmc.org/abstract/med/30735308.
    10.1002/cmdc.201900040
  42. Jesus AR; Soromenho MRC; Raposo LR; Esperança JMSS; Baptista PV; Fernandes AR; Reis PM. "Enhancement of water solubility of poorly water-soluble drugs by new biocompatible N-acetyl amino acid N-alkyl cholinium-based ionic liquids.". European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V (2019): http://europepmc.org/abstract/med/30836180.
    10.1016/j.ejpb.2019.03.004
  43. Catarina Roma-Rodrigues; Rita Mendes; P. V. Baptista; Alexandra Fernandes. "Targeting Tumor Microenvironment for Cancer Therapy". International Journal of Molecular Sciences (2019): http://www.mdpi.com/1422-0067/20/4/840.
    10.3390/ijms20040840
  44. Alves-Barroco C; Roma-Rodrigues C; Balasubramanian N; Guimarães MA; Ferreira-Carvalho BT; Muthukumaran J; Nunes D; et al. "Biofilm development and computational screening for new putative inhibitors of a homolog of the regulatory protein BrpA in Streptococcus dysgalactiae subsp. dysgalactiae.". International journal of medical microbiology : IJMM (2019): http://europepmc.org/abstract/med/30799091.
    10.1016/j.ijmm.2019.02.001
  45. Kourmentza C; Araujo D; Sevrin C; Roma-Rodriques C; Lia Ferreira J; Freitas F; Dionisio M; et al. "Occurrence of non-toxic bioemulsifiers during polyhydroxyalkanoate production by Pseudomonas strains valorizing crude glycerol by-product.". Bioresource technology (2019): http://europepmc.org/abstract/med/30798087.
    10.1016/j.biortech.2019.02.066
  46. Cinthia Alves-Barroco; Catarina Roma-Rodrigues; Luís R. Raposo; Catarina Brás; Mário Diniz; João Caço; Pedro M. Costa; et al. "Streptococcus dysgalactiae subsp. dysgalactiae isolated from milk of the bovine udder as emerging pathogens: In vitro and in vivo infection of human cells and zebrafish as biological models". MicrobiologyOpen 8 1 (2019): e00623-e00623. https://doi.org/10.1002/mbo3.623.
    10.1002/mbo3.623
  47. Oliveira H; Roma-Rodrigues C; Santos A; Veigas B; Brás N; Faria A; Calhau C; et al. "GLUT1 and GLUT3 involvement in anthocyanin gastric transport- Nanobased targeted approach.". Scientific reports (2019): http://europepmc.org/abstract/med/30692585.
    10.1038/s41598-018-37283-2
  48. Fialho, Letícia; Araújo, Diana; Alves, Vitor D.; Roma-Rodrigues, Catarina; Baptista, Pedro V.; Fernandes, Alexandra R.; Freitas, Filomena; et al. "Cation-mediated gelation of the fucose-rich polysaccharide FucoPol: preparation and characterization of hydrogel beads and their cytotoxicity assessment". (2019): http://hdl.handle.net/10362/93177.
    https://doi.org/10.1080/00914037.2019.1695205
  49. Sutradhar, Manas; Alegria, Elisabete; Ferretti, Francesco; Raposo, Luís R; Guedes Da Silva, M. Fátima C.; Baptista, Pedro; Fernandes, Alexandra; Pombeiro, Armando. "Antiproliferative activity of heterometallic sodium and potassium-dioxidovanadium(V) polymers". (2019): http://hdl.handle.net/10400.21/10589.
    10.1016/j.jinorgbio.2019.110811
  50. Catarina Bravo; M. Paula Robalo; Fernanda Marques; Alexandra R. Fernandes; Diogo A. Sequeira; M. Fátima M. Piedade; M. Helena Garcia; Maria J. Villa de Brito; Tânia S. Morais. "First heterobimetallic Cu(i)–dppf complexes designed for anticancer applications: synthesis, structural characterization and cytotoxicity". New Journal of Chemistry (2019): https://doi.org/10.1039/C9NJ02068C.
    10.1039/C9NJ02068C
  51. Katarzyna Choroba; Barbara Machura; Slawomir Kula; Luis R. Raposo; Alexandra R. Fernandes; Rafal Kruszynski; Karol Erfurt; et al. "Copper(ii) complexes with 2,2':6',2''-terpyridine, 2,6-di(thiazol-2-yl)pyridine and 2,6-di(pyrazin-2-yl)pyridine substituted with quinolines. Synthesis, structure, antiproliferative activity, and catalytic activity in the oxidation of alkanes and alcohols with peroxides". Dalton Transactions (2019): https://doi.org/10.1039/C9DT01922G.
    10.1039/C9DT01922G
  52. Katarzyna Choroba; Barbara Machura; Luis R. Raposo; Jan G. Malecki; Slawomir Kula; Michal Pajak; Karol Erfurt; Anna M. Maron; Alexandra R. Fernandes. "Platinum(ii) complexes showing high cytotoxicity toward A2780 ovarian carcinoma cells". Dalton Transactions (2019): https://doi.org/10.1039/C9DT02894C.
    10.1039/C9DT02894C
  53. Das, K.; Datta, A.; Massera, C.; Roma-Rodrigues, C.; Barroso, M.; Baptista, P.V.; Fernandes, A.R.. "Structural aspects of a trimetallic Cu II derivative: cytotoxicity and anti-proliferative activity on human cancer cell lines". Journal of Coordination Chemistry 72 5-7 (2019): 920-940. http://www.scopus.com/inward/record.url?eid=2-s2.0-85065565968&partnerID=MN8TOARS.
    10.1080/00958972.2019.1597973
  54. Raquel Vinhas; Alexandra Lourenço; Susana Santos; Marcos Lemos; Patrícia Ribeiro; Aida Botelho de Sousa; Pedro V. Baptista; Alexandra R. Fernandes. "A novel BCR-ABL1 mutation in a patient with Philadelphia chromosome-positive B-cell acute lymphoblastic leukemia". OncoTargets and Therapy (2018): https://doi.org/10.2147/OTT.S177019.
    10.2147/OTT.S177019
  55. Rita B. Restani; Rita F. Pires; Anna Tolmatcheva; Rita Cabral; Pedro V. Baptista; Alexandra R. Fernandes; Teresa Casimiro; et al. "POxylated Dendrimer-Based Nano-in-Micro Dry Powder Formulations for Inhalation Chemotherapy". ChemistryOpen 7 10 (2018): 772-779. https://doi.org/10.1002/open.201800093.
    10.1002/open.201800093
  56. Rita B. Restani; Rita F. Pires; Anna Tolmatcheva; Rita Cabral; Pedro V. Baptista; Alexandra R. Fernandes; Teresa Casimiro; Vasco D. B. Bonifácio; Ana Aguiar-Ricardo. "Cover Feature: POxylated Dendrimer-Based Nano-in-Micro Dry Powder Formulations for Inhalation Chemotherapy (ChemistryOpen 10/2018)". ChemistryOpen 7 10 (2018): 751-751. https://doi.org/10.1002/open.201800165.
    10.1002/open.201800165
  57. Noora Svahn; Artur J. Moro; Catarina Roma-Rodrigues; Rakesh Puttreddy; Kari Rissanen; Pedro V. Baptista; Alexandra R. Fernandes; João Carlos Lima; Laura Rodríguez. "Front Cover: The Important Role of the Nuclearity, Rigidity, and Solubility of Phosphane Ligands in the Biological Activity of Gold(I) Complexes (Chem. Eur. J. 55/2018)". Chemistry - A European Journal (2018): https://doi.org/10.1002/chem.201804177.
    10.1002/chem.201804177
  58. Sutradhar M; Fernandes AR; Paradinha F; Rijo P; Garcia C; Roma-Rodrigues C; Pombeiro AJL; Charmier AJ. "A new Cu(II)-O-Carvacrotinate complex: Synthesis, characterization and biological activity.". Journal of inorganic biochemistry (2018): http://europepmc.org/abstract/med/30342353.
    10.1016/j.jinorgbio.2018.09.018
  59. Vinhas R; Lourenço A; Santos S; Ribeiro P; Silva M; de Sousa AB; Baptista PV; Fernandes AR. "A double Philadelphia chromosome-positive chronic myeloid leukemia patient, co-expressing P210BCR-ABL1 and P195BCR-ABL1 isoforms.". Haematologica (2018): http://europepmc.org/abstract/med/30093395.
    10.3324/haematol.2018.192534
  60. Ribeiro, A. P. C.; Anbu, S.; Alegria, Elisabete; Fernandes, Alexandra; Baptista, Pedro; Mendes, R.; Matias, A. S.; et al. "Evaluation of cell toxicity and DNA and protein binding of green synthesized silver nanoparticles". (2018): http://hdl.handle.net/10400.21/9121.
    10.1016/j.biopha.2018.02.069
  61. Pedrosa, Pedro; Mendes, Rita; Cabral, Rita; Martins, Luísa M. D. R. S.; Baptista, Pedro V.; Fernandes, Alexandra R.; DCV - Departamento de Ciências da Vida; et al. "Combination of chemotherapy and Au-nanoparticle photothermy in the visible light to tackle doxorubicin resistance in cancer cells". Scientific Reports 8 1 (2018): http://www.scopus.com/inward/record.url?scp=85050817470&partnerID=8YFLogxK.
    https://doi.org/10.1038/s41598-018-29870-0
  62. Lenis-Rojas, Oscar A.; Robalo, Maria Paula; Tomaz, Ana Isabel; Carvalho, Andreia; Fernandes, Alexandra R.; Marques, Fernanda; Folgueira, Mónica; et al. "Ru-II(p-cymene) compounds as effective and selective anticancer candidates with no toxicity in vivo". (2018): http://hdl.handle.net/10400.21/8964.
    10.1021/acs.inorgchem.8b01270
  63. Gomes, S.E.; Pereira, D.M.; Roma-Rodrigues, C.; Fernandes, A.R.; Borralho, P.M.; Rodrigues, C.M.P.. "Convergence of MIR-143 overexpression, oxidative stress and cell death in HCT116 human colon cancer cells". PLoS ONE 13 1 (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85040986423&partnerID=MN8TOARS.
    10.1371/journal.pone.0191607
  64. Baptista, P.V.; McCusker, M.P.; Carvalho, A.; Ferreira, D.A.; Mohan, N.M.; Martins, M.; Fernandes, A.R.; et al. "Nano-strategies to fight multidrug resistant bacteria-"A Battle of the Titans"". Frontiers in Microbiology 9 JUL (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85049384316&partnerID=MN8TOARS.
    10.3389/fmicb.2018.01441
  65. Subhabrata Sen; Chandramohan Bathula; Catarina Rodrigues; Alexandra Fernandes; Jyoti Chauhan. "Synthesis of tetrahydro-1H-indolo[2, 3-b]pyrrolo[3, 2-c]quinolones via intramolecular oxidative ring rearrangement of tetrahydro-ß-carbolines and their biological evaluation". New Journal of Chemistry (2018): https://doi.org/10.1039%2Fc7nj04616b.
    10.1039/c7nj04616b
  66. Alves, P. U.; Vinhas, R.; Fernandes, A. R.; Birol, S. Z.; Trabzon, L.; Bernacka-Wojcik, I.; Igreja, R.; et al. "Multifunctional microfluidic chip for optical nanoprobe based RNA detection - application to Chronic Myeloid Leukemia". Sci Rep 8 1 (2018): 381-381. https://www.ncbi.nlm.nih.gov/pubmed/29321602.
    10.1038/s41598-017-18725-9
  67. Svahn, N.; Moro, A.J.; Roma-Rodrigues, C.; Puttreddy, R.; Rissanen, K.; Baptista, P.V.; Fernandes, A.R.; Lima, J.C.; Rodríguez, L.. "The Important Role of the Nuclearity, Rigidity, and Solubility of Phosphane Ligands in the Biological Activity of Gold(I) Complexes". Chemistry (Weinheim an der Bergstrasse, Germany) 24 55 (2018): 14654-14667. http://www.scopus.com/inward/record.url?eid=2-s2.0-85054065949&partnerID=MN8TOARS.
    10.1002/chem.201804176
  68. Maron, A.; Czerwinska, K.; Machura, B.; Raposo, L.; Roma-Rodrigues, C.; Fernandes, A.R.; Malecki, J.G.; et al. "Spectroscopy, electrochemistry and antiproliferative properties of Au(iii), Pt(ii) and Cu(ii) complexes bearing modified 2,2':6',2''-terpyridine ligands". Dalton Transactions 47 18 (2018): 6444-6463. http://www.scopus.com/inward/record.url?eid=2-s2.0-85046839407&partnerID=MN8TOARS.
    10.1039/c8dt00558c
  69. Peixoto, D.; Figueiredo, M.; Malta, G.; Roma-Rodrigues, C.; Baptista, P.V.; Fernandes, A.R.; Barroso, S.; et al. "Synthesis, Cytotoxicity Evaluation in Human Cell Lines and in Vitro DNA Interaction of a Hetero-Arylidene-9(10H)-Anthrone". European Journal of Organic Chemistry 2018 4 (2018): 545-549. http://www.scopus.com/inward/record.url?eid=2-s2.0-85041287294&partnerID=MN8TOARS.
    10.1002/ejoc.201701500
  70. Morais, T.S.; Jousseaume, Y.; Piedade, M.F.M.; Roma-Rodrigues, C.; Fernandes, A.R.; Marques, F.; Villa De Brito, M.J.; Helena Garcia, M.. "Important cytotoxic and cytostatic effects of new copper(i)-phosphane compounds with N,N, N,O and N,S bidentate ligands". Dalton Transactions 47 23 (2018): 7819-7829. http://www.scopus.com/inward/record.url?eid=2-s2.0-85048401535&partnerID=MN8TOARS.
    10.1039/c8dt01653d
  71. Das, K.; Beyene, B.B.; Datta, A.; Garribba, E.; Roma-Rodrigues, C.; Silva, A.; Fernandes, A.R.; Hung, C.-H.. "EPR and electrochemical interpretation of bispyrazolylacetate anchored Ni(ii) and Mn(ii) complexes: Cytotoxicity and anti-proliferative activity towards human cancer cell lines". New Journal of Chemistry 42 11 (2018): 9126-9139. http://www.scopus.com/inward/record.url?eid=2-s2.0-85047986859&partnerID=MN8TOARS.
    10.1039/c8nj01033a
  72. Fernandes, A.R.; Jesus, J.; Martins, P.; Figueiredo, S.; Rosa, D.; Martins, L.M.R.D.R.S.; Corvo, M.L.; et al. "Multifunctional gold-nanoparticles: A nanovectorization tool for the targeted delivery of novel chemotherapeutic agents". Journal of Controlled Release 245 (2017): 52-61. http://www.scopus.com/inward/record.url?eid=2-s2.0-84999008906&partnerID=MN8TOARS.
    10.1016/j.jconrel.2016.11.021
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  131. Torres, F.; Ivanova-Dragoeva, A.; Pereira, M.; Veiga, J.; Rodrigues, A.S.; Sousa, A.B.; Tavares, P.; Fernandes, A.R.. "An e6a2 BCR-ABL fusion transcript in a CML patient having an iliac chloroma at initial presentation [7]". Leukemia and Lymphoma 48 5 (2007): 1034-1037. http://www.scopus.com/inward/record.url?eid=2-s2.0-34547412407&partnerID=MN8TOARS.
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    10.1128/EC.00290-06
  133. Cerqueira, R.; Evangelista, T.; Lameiras, L.; Conceição, I.; De Carvalho, M.; Tavares, P.; Fernandes, A.R.. "Novel mutation of the myelin P0 gene (MPZ) in a Portuguese family with Charcot-Marie-Tooth type 1 disease". Sinapse 7 1 (2007): 4-9. http://www.scopus.com/inward/record.url?eid=2-s2.0-34249945579&partnerID=MN8TOARS.
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  136. Simões, T.; Mira, N.P.; Fernandes, A.R.; Sá-Correia, I.. "The SPI1 gene, encoding a glycosylphosphatidylinositol-anchored cell wall protein, plays a prominent role in the development of yeast resistance to lipophilic weak-acid food preservatives". Applied and Environmental Microbiology 72 11 (2006): 7168-7175. http://www.scopus.com/inward/record.url?eid=2-s2.0-33751006150&partnerID=MN8TOARS.
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  137. Coelho, T.; Santos, M.; Cerqueira, R.; Pires, M. M.; Lameiras, L.; Gabriel, H.; Fernandes, A. R.; Tavares, P.; Guimaraes, A.. "Three novel mutations of the myelin Po gene (MPZ) in Portuguese families with CMT1B". Neuromuscular Disorders 16 9-10 (2006): 665-665.
    10.1016/j.nmd.2006.05.079
  138. Fernandes, A.R.; Mira, N.P.; Vargas, R.C.; Canelhas, I.; Sá-Correia, I.. "Saccharomyces cerevisiae adaptation to weak acids involves the transcription factor Haa1p and Haa1p-regulated genes". Biochemical and Biophysical Research Communications 337 1 (2005): 95-103. http://www.scopus.com/inward/record.url?eid=2-s2.0-25844432253&partnerID=MN8TOARS.
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Capítulo de livro
  1. Joana Silva; Alexandra Fernandes; P. V. Baptista. "Application of Nanotechnology in Drug Delivery". editado por Sezer, {Ali Demir. InTech, 2014.
    10.5772/58424
  2. Alexandra Fernandes. "Overview of HCM genomics and transcriptomics: molecular tools in HCM assessment for application in clinical medicine.". editado por Ltd, {IConcept Press, in press-in press. iConcept Press Ltd, 2014.
Livro
  1. Fernandes, A.R.; Baptista, P.V.. Gene silencing using multifunctionalized gold nanoparticles for cancer therapy. 2017.
    10.1007/978-1-4939-6646-2_19
  2. Machado, C.M.; Couto, F.M.; Fernandes, A.R.; Santos, S.; Freitas, A.T.. Toward a translational medicine approach for hypertrophic cardiomyopathy. 2012.
    10.1007/978-3-642-32395-9_12
Revisão de livro
  1. Roma-Rodrigues, Catarina; Mendes, Rita; Baptista, Pedro V.; Fernandes, Alexandra R.; UCIBIO - Applied Molecular Biosciences Unit; DCV - Departamento de Ciências da Vida. "Targeting Tumor Microenvironment for Cancer Therapy". http://www.scopus.com/inward/record.url?scp=85061850608&partnerID=8YFLogxK.
    https://doi.org/10.3390/ijms20040840

Outros

Outra produção
  1. Correction to: Nano-in-Micro Sildenafil Dry Powder Formulations for the Treatment of Pulmonary Arterial Hypertension Disorders: The Synergic Effect of POxylated Polyurea Dendrimers, PLGA, and Cholesterol (Part. Part. Syst. Charact, (2020), 37, (1900447), 10.1002/ppsc.19000447). 2020. Rita B. Restani; Márcia T. Tavares; Rita F. Pires; P. V. Baptista; Alexandra Fernandes; Teresa Casimiro; Vasco D. B. Bonifácio; Ana Aguiar-Ricardo. https://novaresearch.unl.pt/en/publications/8a201829-bff5-44ac-9e88-3b9745e399b3.
    10.1002/ppsc.202000251
  2. New lessons from ancient life: marine invertebrates as a source of new drugs. 2019. A. P. Rodrigo; C. Martins; L. Tanoeiro; M. Casaca; A. R. Lopes; A. Jorge Parola; A. P. Matos; et al. https://novaresearch.unl.pt/en/publications/388a1a5a-44fc-46a7-8cb5-bdb178d0d7ee.
    10.1080/07853890.2018.1561901
  3. Gold Nanoparticles in Molecular Diagnostics and Molecular Therapeutics. 2017. Ana S. Matias; Fábio F. Carlos; P. Pedrosa; Alexandra R. Fernandes; Pedro V. Baptista. https://doi.org/10.1007%2F978-3-319-63790-7_16.
    10.1007/978-3-319-63790-7_16
Atividades

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2021 - Atual Nanoheaters – Localized hyperthermia for precise gene delivery
Coorientador de Daniela Ferreira
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2021 - Atual Novel ionic liquids as targeted therapy drugs for lung cancer
Coorientador de Dário Valezim Silva
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2021 - Atual From proteins to Bacteria: a multidisciplinar approach for the rational development of new anti-biofilm and antibacterial agents
Coorientador de João Paquete Ferreira
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2019 - Atual Towards the molecular mechanism underlying the association between preterm birth and periodontal disease
Coorientador de Joana Couceiro
 Biologia (Doutoramento)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2019 - Atual Towards the molecular mechanism underlying resistance in Chronic Myeloid leukemia: new therapies
Orientador de Bilal Rabah Qasim Abdulmawjood
Centro Interuniversitário de História das Ciências e da Tecnologia, Portugal
2018 - Atual Transdermal delivery systems based on natural polymeric biomaterials
Coorientador de Diana Filipa Vieira Araújo
 Engenharia Química (Doutoramento)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2018 - Atual Targeting liver ischemia reperfusion injury: nanoformulations for gene silencing
Coorientador de Ana Margarida Ferreira da Silva
i3Du (Doutoramento)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2014 - Atual Unraveling the host specificity within pyogenic streptococci".
Orientador de Cinthia Barroco
 Biologia (Doutoramento)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2022/03/01 - 2026/02/27 (Gold4TME): Modulation of tumor microenvironment via combinatorial gold nanomedicines
Orientador
 Biologia (Doutoramento)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2016 - 2021/02/26 De pigmentos e toxinas: uma abordagem integradora ao potencial biotecnológico de um poliqueta marinho
Coorientador de Ana Rodrigo
 Ambiente (Doutoramento)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2010 - 2020 >35 Master Thesis in cancer therapy
Orientador
2016 - 2019 Gold Nanoparticles to Tackle Drug Resistance in Cancer
Orientador de Pedro Miguel Pinto Gonçalves Gouveia Pedrosa
 Biociências Moleculares (Doutoramento)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2018 - 2018 Uncovering the role of blood vessels during spinal cord regeneration in zebrafish
Coorientador
 Genética Molecular e Biomedicina (Mestrado)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2014 - 2018 Gold Nanoparticles for nanotherasnostic in Leukaemia addressing CML
Coorientador de Raquel Patricia Gomes Silvestre Vinhas.
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2017 - 2017 Gene Espression Analysis in Cardiac and Adipose Derived Fibroblasts: potential influence of origin and in vitro culture
Coorientador
 Engenharia Biomédica (Mestrado)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2011 - 2016 Transcriptome and proteome profiling of canine mammary tumors: dog as a genetic model for unrevealing mammary cancer molecular signatures
Orientador de Luís Manuel Redondo Raposo
 Biologia (Doutoramento)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2014/09/01 - 2015/10/05 Novos genes no diagnóstico genético de miocardiopatia hipertrófica
Orientador
 Engenharia Biotecnológica (Mestrado)
Universidade de Aveiro Instituto Superior de Contabilidade e Administração, Portugal

Júri de grau académico

Tema
Tipo de participação 		Nome do candidato (Tipo de grau)
Instituição / Organização
2018 Diseño y propiedades de compuestos heterolépticos derivados de Ru (?6-pcimeno)
Arguente
 Jorge Lado Sanjurjo (Doutoramento)
2017 miRNA-143 and miRNA-145 Modulation in colorectal cancer: from anticancer activity to drug sensitization
Vogal
 Sofia Estevão Gomes (Doutoramento)
2017 Diseño e estudio de compuestos de rutenio con actividad biológica
Arguente principal
 Oscar Armando Lenis-Rojas (Doutoramento)
2017 Identifying novel chemotypes against breast cancer: Design, synthesis and biological evaluation
Arguente
 Chandramohan Bathula (Doutoramento)
2016 Biophysical and biological studies of ternary copper(ii) complexes anchored polyethyleneimine – in vitro approach for the search of polymeric anticancer drugs
Arguente
 Kumar Sugumar (Doutoramento)
2016 The role of alpha2,3 and alpha2,6 sialylation in functional aspects of dendritic cells
Vogal
 Hélio Santos Crespo (Doutoramento)
2016 Development of Field Effect sensors for gene expression analysis: Application to cancer diagnosis
Vogal
 Bruno Miguel Ribeiro Veigas (Doutoramento)
2015 Design and Synthesis of small molecule modulators of p53
Arguente
 Carlos Jorge Azevedo Costa Pinheiro. (Doutoramento)
2015 Engineered MRI nanoprobes based on superparamagnetic iron oxide nanoparticles
Vogal
 Susana Palma (Doutoramento)
2014 Base Genética da Hipercolesterolemia Familiar em Portugal
Arguente
 Ana Catarina dos Santos Alves. (Doutoramento)
2014 Gold Nanoparticles for the detection of DNA adducts as biomarkers od exposure to acrylamide
Vogal
 Miguel Ângelo Rodrigues Larguinho (Doutoramento)

Arbitragem científica em conferência

Nome da conferência Local da conferência
1997 - 2021 > 100 poster in international meeting -

Comissão de avaliação

Descrição da atividade
Tipo de assessoria 		Instituição / Organização Entidade financiadora
2018 - 2020 The Royal Society, UK
Avaliador
2017 - 2020 UK Welcome Trust
Avaliador
2017 - 2020 Czech Science Foundation, National Science Center Poland
Avaliador
2015 - 2020 ANR - Agence Nationale de la Researche
Avaliador
2019 - 2019 Bolsas Doutoramento FCT/MCTES
2019 - 2019 Georg Forster Research Fellowships for Experienced Researchers, Alexander von Humboldt-Stiftung Foundation
Avaliador
2015 - 2016 Austrian Science Fund I projects
Avaliador

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2019/07 - 2019/09 Animal experimentation Course - FELASA Type B Curso de Experimentação animal (Curso de Especialização Tecnológica) Universidade de Lisboa Faculdade de Farmácia, Portugal
Distinções

Outra distinção

2013 Prémio Fundação Everis - Heargenetics SA
2002 Award of best poster presentation