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Alexandra R Fernandes (1) Associate Laboratory i4HB - Institute for Health and Bioeconomy, NOVA School of Science and Technology, NOVA University Lisbon, 2819-516 Caparica, Portugal (2) UCIBIO ¿ Applied Molecular Biosciences Unit, Department of Life Sciences, NOVA School of Science and Technology, NOVA University Lisbon, 2819-516 Caparica, Portugal. Since 2008, when she became an independent researcher, Alexandra R Fernandes has been involved in two main areas: Diagnostics and Therapy. Her research has been focusing: 1) development of novel diagnostic tools for the genetic diagnostics of cardiomyopathies. In the context of this area of research, she has been involved in several national and international collaborations. This research work has been translated to a diagnostic company ¿ HEARTGENETICS SA, where she was a co-founder (2013) and COO (between 2013-2015). 2) The application/validation of novel cancer diagnostics tools in clinical samples. Part of this research has been translated to Nano4 Global Lda, where she was a co-founder (2015) and presently COO. 3) The identification of new promising compounds for cancer therapy, in the characterization of their biological targets and their target delivery to cancer cells. She has been interested in the identification of markers of resistance to cancer therapy (mostly in chronic myelogenous leukemia and breast cancer). To accomplish these goals, she has been using in vitro studies with tumour cell lines (2D, 3D spheroids) primary cultures of cancer patients, patient-derived organoids, blood samples and more recently also in vivo studies using eggs embryos, zebrafish and mice. In the context of this area of research, she has been involved in several national and international collaborations and projects. She has also been using the dog as a model organism for the study of canine mammary tumours namely by studying the proteome and the transcriptome of canine mammary tumours with different morphologies and stages to identify new fusion products, new mutations or miRNAs involved in tumour progression. The creation of a database of primary cultures and tissues is also an objective of this research. She has developed a new cell line that has been licensed to Applied Biological Materials (ABM) Inc (https://www.abmgood.com/FR37-CMT-Tumor-Cells-T8002.html). She has been involved in Expert Evaluation of International R&D Projects and Grants (Austrian Science Fund I projects; ANR - Agence Nationale de la Researche; Czech Science Foundation; Welcome Trust, etc) Since 2009 she has been involved in several national and International funded Research Projects (5 has PI/Co-PI (2 with Industry) and 31 as Team member (5 European, 26 National)). She has experience as a scientific adviser (Post-Doc Supervision: 4 (since 2013); PhD Supervision: 16 (since 2011); PhD Jury ¿ member in 11 PhD National Thesis and 3 PhD International Thesis; Master Supervision: 52 (since 2010); Master Jury: 100; Graduation Thesis Supervision: 80; Graduation Thesis Jury: >110; Erasmus - Post-Doc: 2; PhD students: 4; Master students: 1; graduation students: 7. She has published 10 book chapters, more than 180 papers in International Journals with referees, 3 papers in Proceedings of International Conferences (with referees), 3 papers in National Journals with referees. She has more than 50 oral communications in International and National Meetings (with referees) and more than 100 communications in Panel.
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Identification

Personal identification

Full name
Alexandra R Fernandes

Citation names

  • Fernandes, Alexandra
  • Alexandra R Fernandes

Author identifiers

Ciência ID
021D-7DC8-C92F
ORCID iD
0000-0003-2054-4438
Google Scholar ID
https://scholar.google.pt/citations?user=7ZUgRWAAAAAJ&hl=pt-PT
Researcher Id
C-7465-2011
Scopus Author Id
7201782186

Email addresses

  • ma.fernandes@fct.unl.pt (Professional)

Telephones

Telephone
  • 212948530 (Professional)

Addresses

  • Departamento Ciências da Vida, FCT-UNL. Caparica, 2829-516, Caparica, Almada, Portugal (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Medical Biotechnology - Gene-based Diagnostics and Therapeutic Interventions
  • Medical and Health Sciences - Medical Biotechnology - Health-Related Biotechnology
  • Medical and Health Sciences - Basic Medicine - Human Genetics

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
French Intermediate (B1) Intermediate (B1) Intermediate (B1) Intermediate (B1)
German Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
Education
Degree Classification
2022/07/22 - 2022/07/22
Concluded
 Biociências Moleculares (Título de Agregado)
Universidade Nova de Lisboa, Portugal
2000/04/18
Concluded
 Biotecnology (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
"A H+-ATPase da membrana plasmática e a resposta ao stress oxidativo, em particular ao stress pelo cobre, em Saccharomyces cerevisiae" (THESIS/DISSERTATION)
 Aproved
2000/04/18
Concluded
 Biotecnologia (Doutoramento)
Major in Sem especialidade
Universidade de Lisboa Instituto Superior Técnico, Portugal
"A H+- Atpase da Membrana Plasmática e a Resposta ao Stress Oxidativo, em Particular ao Stress pelo Cobre, em Saccharomyces Cerevisiae" (THESIS/DISSERTATION)
1995/09/01
Concluded
 Engenharia Bioquímica (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
"n/a" (THESIS/DISSERTATION)
 Parte escolar - 17 valores
1994/09/05
Concluded
 Engenharia Química (Ramo Biotecnologia) (Licenciatura)
Universidade de Lisboa Instituto Superior Técnico, Portugal
"n/a" (THESIS/DISSERTATION)
 15 valores
Affiliation

Science

Category
Host institution 		Employer
2015/01/01 - Current Principal Investigator (Research) REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
2015/01/01 - 2015 Researcher (Research) Universidade de Lisboa Centro de Química Estrutural, Portugal
2008/12/01 - 2014/12/31 Researcher (Research) Universidade de Lisboa Instituto Superior Técnico, Portugal
2009 - 2013 Researcher (Research) Universidade de Lisboa Centro de Química Estrutural, Portugal
2006 - 2008 Researcher (Research) Universidade de Lisboa, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2023/03 - Current Associate Professor (University Teacher) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2013/03/01 - Current Assistant Professor (University Teacher) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2016 - 2018 Assistant Professor (University Teacher) Universidade Nova de Lisboa, Portugal
2013 - 2016 Assistant Professor (University Teacher) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2010/10/01 - 2013/02/28 Associate Professor (University Teacher) Universidade Lusófona de Humanidades e Tecnologias, Portugal
2009/04/01 - 2013/02/28 Invited Assistant (University Teacher) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2000/04/20 - 2010/09/30 Assistant Professor (University Teacher) Universidade Lusófona de Humanidades e Tecnologias, Portugal
1998/04/20 - 2000/03/31 Assistant (University Teacher) Universidade Lusófona de Humanidades e Tecnologias, Portugal

Positions / Appointments

Category
Host institution 		Employer
2021/05/01 - Current Master Coordinator - Master in Molecular Genetics and Biomedicine Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Others

Category
Host institution 		Employer
2015/12/14 - Current Founder of Nano4Global. Lda Nano4 Global Lda, Portugal
2013/04/01 - 2015/09/30 Founder of Heartgenetics SA Shareholder of Heartgenetics HeartGenetics Genetics and Biotechnology SA, Portugal
2010/06/01 - 2013/03/01 Coordinator of the Master in Cancer Biology Universidade Lusófona de Humanidades e Tecnologias, Portugal
2009/10/01 - 2013/03/01 Coordinator of the Master in Biotechnology Engineering Universidade Lusófona de Humanidades e Tecnologias, Portugal
2010/09/01 - 2011/08/31 Invited assistant Professor (Coordinator of the Molecular Biotechnology Module in the Life Sciences PhD Program) Universidade do Porto, Portugal
2009/05/01 - 2011/05/12 Advisor of the Genetic and Cellular Biology Group of the Portuguese Society of Cardiology Sociedade Portuguesa de Cardiologia, Portugal
2009/10/01 - 2010/12/31 Coordinator of the Master in Development Biology Universidade Lusófona de Humanidades e Tecnologias, Portugal
2009/03/01 - 2010/09/30 Coordinator of the "Pós-Graduação Genética Clinica e Laboratorial" Universidade Lusófona de Humanidades e Tecnologias, Portugal
2005/09/01 - 2008/03/31 Molecular Biology Laboratory Director Centro de Genética Clínica e Patologia SA, Portugal
2000 - 2005 Pos-doc research Universidade de Lisboa Instituto Superior Técnico, Portugal
Projects

Grant

Designation Funders
2020/05/15 - 2020/11/15 dPCR4free DNA (PTDC/BTM- SAL/31201/2017)
PTDC/BTM- SAL/31201/2017
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing

Contract

Designation Funders
2023/02/13 - 2026/02/12 NANOHEAT – Gold nanoconjugates for improved photothermal ablation of colorectal cancer
2022.04315.PTDC
10.54499/2022.04315.PTDC
Co-Principal Investigator (Co-PI)
Associação para a Inovação e Desenvolvimento da FCT, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2021/01/01 - 2025/12/31 Institute for Health and Bioeconomy
LA/P/0140/2020
10.54499/LA/P/0140/2020
Principal investigator
Universidade NOVA de Lisboa, Portugal

Associação para a Inovação e Desenvolvimento da FCT, Portugal

Unidade de Ciências Biomoleculares Aplicadas, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2022/01/01 - 2024/12/31 A molecular and nano approach to target the RANK-TRAF6 interface for bone metastases treatment
PTDC/QUI-OUT/3854/2021
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal

Associação para a Inovação e Desenvolvimento da FCT, Portugal

Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal

Universidade de Lisboa Centro de Ciências e Tecnologias Nucleares, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2020/01/01 - 2024/12/31 Applied Molecular Biosciences Unit
UIDB/04378/2020
10.54499/UIDB/04378/2020
Principal investigator
Universidade NOVA de Lisboa, Portugal

Unidade de Ciências Biomoleculares Aplicadas, Portugal

Associação para a Inovação e Desenvolvimento da FCT, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2020/01/01 - 2024/12/31 Applied Molecular Biosciences Unit
UIDP/04378/2020
10.54499/UIDP/04378/2020
Principal investigator
Universidade NOVA de Lisboa, Portugal

Unidade de Ciências Biomoleculares Aplicadas, Portugal

Associação para a Inovação e Desenvolvimento da FCT, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2021/03/29 - 2024/03/28 Derivados de triptofanol para reativação de formas mutadas da p53 <br>
PTDC/QUI-QOR/1304/2020
Researcher
Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal

Associação para a Inovação e Desenvolvimento da FCT, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2021/03/01 - 2024/02/29 Fármacos de ruténio-péptido: flechas para alvejar seletivamente o cancro da mama
PTDC/QUI-QIN/0146/2020
Researcher
Universidade de Lisboa Centro de Química Estrutural, Portugal

Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal

Associação para a Inovação e Desenvolvimento da FCT, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2018/09/01 - 2022/07/31 Líquidos Iónicos Farmaceuticos como uma nova plataforma para o tratamento efectivo da Tuberculose (TB-ILs)
PTDC/QUI-QOR/32406/2017
Universidade NOVA de Lisboa, Portugal

Associação para a Inovação e Desenvolvimento da FCT, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2018/08/01 - 2022/07/31 Nanomateriais Auto-Organizados Para Entrega Fotocontrolada de Fármacos e Genes
PTDC/QUI-COL/32351/2017
Associação para a Inovação e Desenvolvimento da FCT, Portugal

Universidade do Porto, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2019/02/01 - 2022/01/31 Valorização de Moléculas Isoladas de Anfíbios Aquáticos Portugueses
PTDC/BII-BIO/31158/2017
Researcher
Instituto de Biologia Molecular e Celular, Portugal

Associação para a Inovação e Desenvolvimento da FCT, Portugal

REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
Fundação para a Ciência e a Tecnologia

Governo da República Portuguesa Ministério da Ciência Tecnologia e Ensino Superior
Ongoing
2019/01/31 - 2022/01/01 Quimica macrocíclica y organometálica – QUIMIOR.
1. CONSOLIDACIÓN 2019 GRC GI-1581
Researcher
REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal

Universidade de Santiago de Compostela Facultade de Química, Spain
Ongoing
2019/01/01 - 2022/01/01 Synthesis of Heterocyclic Compounds for biological and technological applications
2. FAPESP:2018/00544-4
Researcher
REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal

Fundação de Amparo à Pesquisa do Estado de São Paulo, Brazil
Ongoing
2020/06 - 2021/12/31 ACTPHAST
ACTPHAST: Innovation Project Proposal project ID P2019 -36
ACTPHAST: Innovation Project Proposal project ID P2019 -36
Researcher
Nano4 Global Lda, Portugal
 N/A
Concluded
2018/07/01 - 2021/12/31 SME Phase II
SME Phase II
Principal investigator
Nano4 Global Lda, Portugal
 Conseil de l'Union Europeenne
Concluded
2018/10/01 - 2021/09/30 Plataforma de Microfluidica Integrada para a deteção do cancro através de PCR digital de ADN livre circulante
PTDC/BTM-SAL/31201/2017
PTDC/BTM/SAL/31201/2017
Researcher
Associação para a Inovação e Desenvolvimento da FCT, Portugal

REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
Fundação para a Ciência e a Tecnologia

Governo da República Portuguesa Ministério da Ciência Tecnologia e Ensino Superior
Ongoing
2018/10/01 - 2021/09/30 Invertebrados marinhos enquanto fonte de novas biotoxinas: Uma investigação sobre função e aplicação baseada em venómica de poliquetas
PTDC/BTA-BTA/28650/2017
Egas Moniz - Cooperativa de Ensino Superior Crl, Portugal

Associação para a Inovação e Desenvolvimento da FCT, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2018/09/01 - 2021/01/31 EraNet MAGICCELLGene: Localized MAGnetIC hyperthermia CELL-based GENE therapy for immune modulation.
EraNet MAGICCELLGene/2015
Researcher
REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
 Conseil de l'Union Europeenne
Ongoing
2019 - 2021 Detecção e Caracterização de Nanopartículas Usando Nanoporos de Estado Sólido: Uma Abordagem Única Molécula
PTDC/NAN/MAT/31100/2017
PTDC/NAN-MAT/31100/2017
Researcher
REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal

Universidade Nova de Lisboa, Portugal

Associação para a Inovação e Desenvolvimento da FCT, Portugal
Governo da República Portuguesa Ministério da Ciência Tecnologia e Ensino Superior

Conseil de l'Union Europeenne

Fundação para a Ciência e a Tecnologia
Ongoing
2019 - 2021 Marine invertebrates as source of novel biotoxins: Investigating function and application through Polychaeta venomics
PTDC/BTA/28650/2017
Researcher
REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
 Governo da República Portuguesa Ministério da Ciência Tecnologia e Ensino Superior
Ongoing
2019 - 2021 Novel photoinduced-molecules for cancer therapy
PTDC/QUI/CCL/032351/2017
Researcher
REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
 Governo da República Portuguesa Ministério da Ciência Tecnologia e Ensino Superior
2019 - 2021 The MARVEN Project -The Portuguese biotechnological database for marine animal venoms and toxins
FA_05_2017_007
Researcher
REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
 Fundo Azul
Ongoing
2019 - 2021 Ionic liquids as a new platform for tuberculosis treatment (TB-ILs)
PTDC/QUI/QER/32406/2017
PTDC/QUI/QER/32406/2017
Researcher
REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
 Governo da República Portuguesa Ministério da Ciência Tecnologia e Ensino Superior
Ongoing
2017/09/01 - 2020/08/31 MAGICCELLGene: hypertermia magnética localizada para terapia génica em células para modulação imunitária
M-ERA-NET2/0008/2016
Associação para a Inovação e Desenvolvimento da FCT, Portugal

Unidade de Ciências Biomoleculares Aplicadas, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2020/01/06 - 2020/06/01 Quick COVID-19 Detection (QuiCoviDe)
RESEARCH4COVID19/2020
Researcher
REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
Concluded
2016/04/15 - 2020/03/31 Uma plataforma - Detecção multiplex de biomarcadores em Artrite Reumatoide
Inn-INDIGO/0002/2015
Associação para a Inovação e Desenvolvimento da FCT, Portugal

Unidade de Ciências Biomoleculares Aplicadas, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2016/04/01 - 2020/03/30 RA DETECT - One Platform – multiple biomarker detection of Rheumatoid Arthritis
Era-Net - Inno Indigo 2015
Researcher
REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
 European Commission
Concluded
2019/01/01 - 2019/12/31 Centro de Química Estrutural
UID/QUI/00100/2019
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal

FCiênciasID Associação para a Investigação e Desenvolvimento de Ciências, Portugal

Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal

Universidade de Lisboa Centro de Química Estrutural, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2019/01/01 - 2019/12/31 Unidade de Ciências Biomoleculares Aplicadas
UID/Multi/04378/2019
154717UID
Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2016/07/03 - 2019/12/31 De pigmentos e toxinas: uma abordagem integradora ao potencial biotecnológico de um poliqueta marinho
PTDC/MAR-BIO/0113/2014
Researcher
Associação para a Inovação e Desenvolvimento da FCT, Portugal

Centro de Ciências do Mar e do Ambiente, Portugal

Egas Moniz Cooperativa de Ensino Superior CRL, Portugal

REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
Fundação para a Ciência e a Tecnologia

Koeki Zaidan Hojin Nakayama Hayao Kagaku Gijutsu Bunka Zaidan
Concluded
2016/05/02 - 2019/11/01 Avaliação da especificidade do hospedeiro e das interacções agente patogénico-hospedeiro em Streptococcus
PTDC/CVT-EPI/6685/2014
Researcher
Associação para a Inovação e Desenvolvimento da FCT, Portugal

REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
Fundação para a Ciência e a Tecnologia

Koeki Zaidan Hojin Nakayama Hayao Kagaku Gijutsu Bunka Zaidan
Concluded
2015/01/01 - 2018/01/01 Cytotoxicity and photo-cytotoxicity of nitrosyl ruthenium anticancer drug in aqueous solution or incorporated in a drug delivery system. An innovative purpose for metal based drug
2015/50101-3
Principal investigator
REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
 Conselho Nacional de Desenvolvimento Científico e Tecnológico
Concluded
2017/06 - 2017/12 SME Phase I
SME Phase I
Principal investigator
Nano4 Global Lda, Portugal
Concluded
2016/01/01 - 2017/01/01 Validation of Natural extracts for dermal applications
Vitrobio
Principal investigator
REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
Concluded
2013/06/01 - 2016/12/31 De pequenas moléculas bioactivas a uma abordagem ÓMICA integrada: Ferramentas de Espectrometria de Massa para a compreensão mecanística de propriedades farmacológicas e funcionais, toxicidade e respostas ao stress
RECI/QEQ-MED/0330/2012
Researcher
Universidade de Lisboa Centro de Química Estrutural, Portugal

Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal

Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

Centro Hospitalar de Lisboa Central EPE, Portugal

Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal

Hospital Professor Doutor Fernando Fonseca EPE, Portugal
Fundação para a Ciência e a Tecnologia

Fundação para a Ciência e a Tecnologia, I.P.
Concluded
2013/01/01 - 2016/03/01 Silence is golden (siAu) - silencing the silencers via multifunctional gold nanoconjugates towards cancer therapy
PTDC/BBB-NAN/1812/2012
Researcher
Universidade de Lisboa Centro de Química Estrutural, Portugal

REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal

Universidade Nova de Lisboa Centro de Toxicogenómica e Saúde Humana, Portugal

Associação para a Inovação e Desenvolvimento da FCT, Portugal
Fundação para a Ciência e a Tecnologia, I.P.

Fundação para a Ciência e a Tecnologia
Concluded
2013/01/01 - 2016/01/01 Unraveling the host specificity within Streptococcus dysgalactiae subsp. dysgalactiae
PTDC/CVT-EPI/4651/2012
Researcher
Universidade de Lisboa Centro de Química Estrutural, Portugal

REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal

Associação para a Inovação e Desenvolvimento da FCT, Portugal
Fundação para a Ciência e a Tecnologia, I.P.

Fundação para a Ciência e a Tecnologia
Concluded
2015 - 2016 Evaluation of deep-sea animal lipid extracts as new natural anticancer cellular therapy
APCL|FCG 2014
Principal investigator
REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
 Associação Portuguesa Contra a Leucemia
Concluded
2011/01/01 - 2012/12/31 Projecto Estratégico - UI 100 - 2011-2012
PEst-OE/QUI/UI0100/2011
Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2008/01/01 - 2010/01/01 Imatinib resistance and targets in Chronic Myeloid Leukaemia: post-genomic approaches using yeast as a model system
PTDC/SAU-FCF/71760/2006
Researcher
Centro de Genética Clínica e Patologia SA, Portugal
 Governo da República Portuguesa Ministério da Ciência Tecnologia e Ensino Superior
Concluded
2007/01/01 - 2010/01/01 Mechanisms of resistance to Imatinib in Chronic Myeloid Leukemia
PTDC/SAU-GMG/71720/2006
Researcher
Centro de Genética Clínica e Patologia SA, Portugal

Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
Governo da República Portuguesa Ministério da Ciência Tecnologia e Ensino Superior

Fundação para a Ciência e a Tecnologia
Concluded
2006/01/02 - 2008/01/01 Elucidação das complexas redes de regulação que actuam na levedura sujeita a drogas/stresse químico: abordagens de expressão genómica e de bioinformática
PDCT/BIO/56838/2004
Universidade de Lisboa Instituto Superior Técnico, Portugal

Universidade de Lisboa Instituto Superior Técnico, Portugal

Instituto de Engenharia de Sistemas e Computadores Investigação e Desenvolvimento em Lisboa, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2005/01/01 - 2007/12/31 DBYeast: Infraestruturas e algoritmos para análise e identificação de redes de regulação genética
POSC/EIA/57398/2004
Instituto de Engenharia de Sistemas e Computadores Investigação e Desenvolvimento em Lisboa, Portugal

Universidade de Lisboa Instituto Superior Técnico, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2003/02/01 - 2005 Adaptation and resistance to organic acid food preservatives in yeast
info:eu-repo/grantAgreement/FCT/POCI/45347/PT
Post-doc Fellow
Universidade do Algarve Faculdade de Ciências e Tecnologia
Concluded
2002 - 2004 Genomic-oriented studies on Saccharomyces cerevisiae
POCTI/BIO/38115/2001
Post-doc Fellow
Concluded
2002 - 2004 Resistência a benomil e outros fungicidas em Saccharomyces cerevisiae: papel de transportadores de múltiplas drogas e sua regulação
POCTI/AGG/38110/2001
Post-doc Fellow
Concluded
2001 - 2003 Strategies to accelerate the produtive biodegradation of several herbicides under environmental stress conditions
HERBICBIOREM 2001
Post-doc Fellow
European Union
Concluded

Other

Designation Funders
2014/01/01 - 2017/01/01 Gold multifunctional nanoparticles for targeting cancer – Cetuximab
Merck-Serono
Principal investigator
REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal

Universidade de Lisboa Centro de Química Estrutural, Portugal
Concluded
Outputs

Publications

Book
  1. Fernandes, A.R.; Baptista, P.V.. Gene silencing using multifunctionalized gold nanoparticles for cancer therapy. 2017.
    10.1007/978-1-4939-6646-2_19
  2. Machado, C.M.; Couto, F.M.; Fernandes, A.R.; Santos, S.; Freitas, A.T.. Toward a translational medicine approach for hypertrophic cardiomyopathy. 2012.
    10.1007/978-3-642-32395-9_12
Book chapter
  1. Cordeiro, Sandra; Roma-Rodrigues, Catarina; Pedro V. Baptista; Alexandra R Fernandes. Corresponding author: Alexandra R Fernandes. "Gold Nanoparticles as a Tool for Combinatorial Nanomedicine". 313-370. World Scientific Publishing Company, 2023.
    Accepted
  2. Joana Silva; Alexandra Fernandes; P. V. Baptista. "Application of Nanotechnology in Drug Delivery". edited by Sezer, {Ali Demir. InTech, 2014.
    10.5772/58424
  3. Alexandra Fernandes. "Overview of HCM genomics and transcriptomics: molecular tools in HCM assessment for application in clinical medicine.". edited by Ltd, {IConcept Press, in press-in press. iConcept Press Ltd, 2014.
Book review
  1. Roma-Rodrigues, Catarina; Mendes, Rita; Baptista, Pedro V.; Fernandes, Alexandra R.; UCIBIO - Applied Molecular Biosciences Unit; DCV - Departamento de Ciências da Vida. "Targeting Tumor Microenvironment for Cancer Therapy". http://www.scopus.com/inward/record.url?scp=85061850608&partnerID=8YFLogxK.
    https://doi.org/10.3390/ijms20040840
Conference abstract
  1. Martins, Carla; Rodrigo, Ana P.; Madeira, Carolina; D' Ambrosio, Mariaelena; C. Gonçalves; A. J. Parola; Grosso, Ana Rita; et al. "Porphyrin pigments in polychaeta: explorations on the evolution of haem metabolism in marine eumetazoans". Paper presented in XVI International Symposium on Marine Natural Products|XI European Conference on Marine Natural Products, Peniche, 2020.
    Published
Conference paper
  1. Catia M Machado; Francisco Couto; Alexandra R Fernandes; Susana Santos; Nuno Cardim; Ana T Freitas; Machado, C.M.; et al. "Semantic characterization of hypertrophic cardiomyopathy disease". 2010.
    10.1109/bibmw.2010.5703841
Conference poster
  1. Ferreira-Silva, Margarida; Faria-Silva, C.; Carvalheiro, Manuela; Simões, Sandra; Fernandes, Eduarda; Baptista, Pedro; Alexandra R Fernandes; Corvo, M. Luisa. "Quercetin liposomes for hepatic ischemia and reperfusion injury a promising therapeutic approach". Paper presented in First Symposium on Advanced Technologies on Drug Delivery, 2021.
  2. Rodrigo, Ana; Grosso, Ana Rita; Mendes, Vera M; Manadas, Bruno; Pedro V. Baptista; Alexandra R Fernandes; Costa, Pedro M.. "Unveiling venomous annelids by combining omics with ecological traits: The example of a phyllodocid". Paper presented in XII European Conference on Marine Natural Products, 2021.
  3. Ferreira-Silva, Margarida; Faria-Silva, Catarina; Carvalheiro, Manuela Colla; Simões, Sandra; Fernandes, Eduarda; Baptista, Pedro Viana; Fernandes, Alexandra; Corvo, M. Luísa. "Evaluation of anti-inflammatory effect of quercetin liposomes in hepatic ischemia and reperfusion injury". Paper presented in XIII Spanish-Portuguese Conference on Controlled Drug Delivery, 2020.
  4. Ferreira-Silva, Margarida; Faria-Silva, Catarina; Carvalheiro, Manuela Colla; Baptista, Pedro; Fernandes, Eduarda; Fernandes, Alexandra; Corvo, M. Luisa. "Evaluation of anti-inflammatory efficacy of liposomal formulations developed for hepatic ischemia and reperfusion injury¿s treatment". Paper presented in 6th International Symposium on Phospholipids in Pharmaceutical Research, 2019.
  5. Rodrigo, Ana P.; Grosso, Ana Rita; Baptista, Pedro; Alexandra R Fernandes; Costa, Pedro M.. "Toxins from an unsuspected invertebrate: a poisonous cocktail from a jawless predatory polychaete". Paper presented in XVI International symposium on marine natural products & XI European conference on marine natural products, 2019.
  6. Ferreira-Silva, Margarida; Faria-Silva, Ana Catarina; Carvalheiro, Manuela Colla; Baptista, Pedro; Josbert Maarten Metselaar; Corvo, M. Luisa; Fernandes, Alexandra. "Assessment Of Anti inflammatory Efficacy Of Liposomal Formulations Developed For The Treatment Of Hepatic Ischemia And Reperfusion Injury". Paper presented in 2019 Controlled Release Society Annual Meeting Exposition, 2019.
  7. Ferreira-Silva, Margarida; Faria-Silva, Catarina; Carvalheiro, Manuela Colla; Baptista, Pedro V; Fernandes, Eduarda; Fernandes, Alexandra; Corvo, M. Luísa. "Development of Quercetin Liposomal Formulations for Hepatic Ischemia/Reperfusion Injury Prevention.". Paper presented in 11th iMed.ULisboa and 4th i3du Postgraduate Students Meeting., 2019.
  8. Ferreira-Silva, Margarida; Faria-Silva, Ana Catarina; Carvalheiro, Manuela; Baptista, Pedro Viana; Fernandes, Eduarda; Fernandes, Alexandra; Corvo, Maria Luísa. "Development of Anti-Inflammatory Liposomal Formulations for Hepatic Ischemia/Reperfusion Injury.". Paper presented in 10th iMed.ULisboa and 3rd i3du Postgraduate Students Meeting., 2018.
  9. Rodrigo, Ana P.; Martins, Carla; Lopes, A.; Alves de Matos, A. P.; Baptista, Pedro; Fernandes, Alexandra; Costa, Pedro M.. "Untravelling the mysteries of a marine Polychaete: Connecting toxicity with fluorescence". Paper presented in Encontro Ciência18, 2018.
  10. Rodrigo, Ana P.; Martins, Carla; Lopes, Ana; Alves de Matos, António P.; Baptista, Pedro V; Alexandra R Fernandes; Costa, Pedro M.. "Unravelling the mysteries of a marine polychaete: connecting toxicity with fluorescence". Paper presented in Encontro Ciência 18, 2018.
  11. Rodrigo, Ana P.; Martins, Carla; Cuevas, N.; Costa, M. H.; Fernandes, Alexandra; Costa, Pedro M.. "Caracterização química, molecular e toxicológica de uma nova biotoxina produzida por um poliqueta marinho: Eulalia viridis". Paper presented in Primeiro Congresso de Biologia Marinha, 2018.
  12. Rodrigo, Ana P.; Martins, Carla; Rodrigues, Catarina R.; Cuevas, Nagore; Martins, Marta; Alves de Matos, António P.; Costa, Maria H.; Alexandra R Fernandes; Costa, Pedro M.. "The biotechnological value of a novel potent marine biotoxin from the polychaete worm Eulalia viridis: chemical and toxicological evaluation". Paper presented in Encontro Ciências 17, 2017.
  13. Raposo, Luís R; Catarina Roma-Rodrigues; João Jesus; Joaquim Henriques; Pedro Faísca; Margarida Alves; Jorge Correia; Pedro Viana Baptista; Alexandra R Fernandes. "New models of mammary tumors for drug development". Paper presented in Ciência 2016 - Encontro de Ciência 2016, 2016.
  14. Muthukumaran, Jayaraman; Freire, Filipe; Balasubramanian, N.; Alexandra R Fernandes; Santos-Sanches, I; Teresa Santos-Silva. "Structural characterization of Biofilm regulatory protein from Streptococcus dysgalactiae subsp. dysgalactiae VSD9 ¿a computational approach". Paper presented in 4th Meeting of Synchrotron Radiation Users from Portugal, 2016.
  15. Raposo, Luís R; Catarina Roma-Rodrigues; Joaquim Henriques; Pedro Faísca; Margarida Alves; Jorge Correia; Alexandra R Fernandes. "Molecular characterization of miRs and mRNAs in canine mammary tumours and their role biomarkers in the metastatic progression". Paper presented in II Jornadas NOVA Saúde 2015, 2015.
  16. Raposo, L.; Henriques, Joaquim; Faísca, Rui Pedro Brás Martins ; Alves, Margarida; Correia, J.; Fernandes, Alexandra. "Molecular characterization of canine mammary tumours: the role of miRs and mRNAs as biomarkers in the metastatic transition". Paper presented in European Society of Veterinary Oncology Annual Congress, 2014.
  17. Raposo, L.; Santos, S.; Henriques, Joaquim; Alves, Margarida; Faísca, Rui Pedro Brás Martins ; Beselga, A.; Correia, J.; Alexandra R Fernandes. "Insights into the molecular basis of canine mammary cancer: the use of miRs in the characterization of canine mammary tumours". Paper presented in European Society of Veterinary Oncology Annual Congress, 2013.
Journal article
  1. Bilal Abdulmawjood; Catarina Roma-Rodrigues; Pedro V. Baptista; Alexandra R. Fernandes. "Tackling Imatinib Resistance via Au-nanoconjugates using A Cml Resistant Cell Line". Particle & Particle Systems Characterization (2024): https://doi.org/10.1002/ppsc.202300090.
    10.1002/ppsc.202300090
  2. Sofia Friães; Cândida Trigueiros; Clara S. B. Gomes; Alexandra R. Fernandes; Oscar A. Lenis-Rojas; Marta Martins; Beatriz Royo. "Antimicrobial Activity of Manganese(I) Tricarbonyl Complexes Bearing 1,2,3-Triazole Ligands". Molecules (2023): https://doi.org/10.3390/molecules28217453.
    10.3390/molecules28217453
  3. Patrícia Branco; Elisabete Muchagato Maurício; Ana Costa; Diogo Ventura; Catarina Roma-Rodrigues; Maria Paula Duarte; Alexandra R. Fernandes; Catarina Prista. "Exploring the Multifaceted Potential of a Peptide Fraction Derived from Saccharomyces cerevisiae Metabolism: Antimicrobial, Antioxidant, Antidiabetic, and Anti-Inflammatory Properties". Antibiotics (2023): https://doi.org/10.3390/antibiotics12081332.
    10.3390/antibiotics12081332
  4. Katarzyna Choroba; Beatriz Filipe; Anna Switlicka; Mateusz Penkala; Barbara Machura; Alina Bienko; Sandra Cordeiro; Pedro V. Baptista; Alexandra R. Fernandes. "In Vitro and In Vivo Biological Activities of Dipicolinate Oxovanadium(IV) Complexes". Journal of Medicinal Chemistry (2023): https://doi.org/10.1021/acs.jmedchem.3c00255.
    10.1021/acs.jmedchem.3c00255
  5. Diana Araújo; Matilde Martins; Patrícia Concórdio-Reis; Catarina Roma-Rodrigues; Maria Morais; Vítor D. Alves; Alexandra R. Fernandes; Filomena Freitas. "Novel Hydrogel Membranes Based on the Bacterial Polysaccharide FucoPol: Design, Characterization and Biological Properties". Pharmaceuticals (2023): https://doi.org/10.3390/ph16070991.
    10.3390/ph16070991
  6. Beatriz B. Oliveira; Beatriz Costa; Bárbara Morão; Sandra Faias; Bruno Veigas; Lucília Pebre Pereira; Cristina Albuquerque; et al. "Combining the amplification refractory mutation system and high-resolution melting analysis for KRAS mutation detection in clinical samples". Analytical and Bioanalytical Chemistry 415 14 (2023): 2849-2863. https://novaresearch.unl.pt/en/publications/b2c4ea4d-1977-452d-ab83-a93d551434ce.
    10.1007/s00216-023-04696-6
  7. Morão, Barbara; Beatriz B. Oliveira; Costa, Beatriz; Saraiva, Susana; Fidalgo, Catarina; Faias, Sandra; Mascarenhas-Lemos, Luís; et al. "Su1406 A NOVEL MOLECULAR ASSAY TO EVALUATE KRAS MUTATIONS IN TUMOR AND PLASMA SAMPLES OF PATIENTS WITH PANCREATIC DUCTAL ADENOCARCINOMA AND THEIR PROGNOSTIC IMPACT: ONE STEP CLOSER TO TRANSLATE KRAS GENOTYPING INTO CLINICAL PRACTICE". Gastroenterology 164 6 (2023): S-599. http://dx.doi.org/10.1016/s0016-5085(23)02399-5.
    10.1016/s0016-5085(23)02399-5
  8. Catarina Roma-Rodrigues; Alexandra R. Fernandes; Pedro V. Baptista. "Exploring RAB11A Pathway to Hinder Chronic Myeloid Leukemia-Induced Angiogenesis In Vivo". Pharmaceutics (2023): https://doi.org/10.3390/pharmaceutics15030742.
    10.3390/pharmaceutics15030742
  9. Ana F. Amendoeira; André Luz; Ruben Valente; Catarina Roma-Rodrigues; Hasrat Ali; Johan E. van Lier; Fernanda Marques; Pedro V. Baptista; Alexandra R. Fernandes. "Cell Uptake of Steroid-BODIPY Conjugates and Their Internalization Mechanisms: Cancer Theranostic Dyes". International Journal of Molecular Sciences (2023): https://doi.org/10.3390/ijms24043600.
    10.3390/ijms24043600
  10. Diana Araújo; Thomas Rodrigues; Catarina Roma-Rodrigues; Vítor D. Alves; Alexandra R. Fernandes; Filomena Freitas. "Chitin-Glucan Complex Hydrogels: Physical-Chemical Characterization, Stability, In Vitro Drug Permeation, and Biological Assessment in Primary Cells". Polymers (2023): https://doi.org/10.3390/polym15040791.
    10.3390/polym15040791
  11. Ruben Valente; Sandra Cordeiro; André Luz; Catarina Roma-Rodrigues; P. V. Baptista; Alexandra Fernandes. "Doxorubicin-sensitive and -resistant colorectal cancer spheroid models". Frontiers in Cell and Developmental Biology 11 (2023): https://novaresearch.unl.pt/en/publications/c29b6a91-5137-44b1-a695-2865cb230b08.
    10.3389/fcell.2023.1310397
  12. Miquel Nuez-Martínez; María Queralt-Martín; Amanda Muñoz-Juan; Vicente M. Aguilella; Anna Laromaine; Francesc Teixidor; Clara Viñas; et al. "Boron clusters (ferrabisdicarbollides) shaping the future as radiosensitizers for multimodal (chemo/radio/PBFR) therapy of glioblastoma". Journal of Materials Chemistry B 10 47 (2022): 9794-9815. https://novaresearch.unl.pt/en/publications/f4ff3088-e1dc-4667-8f3d-512243681ac2.
    10.1039/d2tb01818g
  13. Danielle Twilley; Velaphi C. Thipe; Navneet Kishore; Pierce Bloebaum; Catarina Roma-Rodrigues; Pedro V. Baptista; Alexandra R. Fernandes; et al. "Antiproliferative Activity of Buddleja saligna (Willd.) against Melanoma and In Vivo Modulation of Angiogenesis". Pharmaceuticals (2022): https://doi.org/10.3390/ph15121497.
    10.3390/ph15121497
  14. Oscar A. Lenis-Rojas; Catarina Roma-Rodrigues; Beatriz Carvalho; Pablo Cabezas-Sainz; Sabela Fernández Vila; Laura Sánchez; Pedro V. Baptista; Alexandra R. Fernandes; Beatriz Royo. "In Vitro and In Vivo Biological Activity of Ruthenium 1,10-Phenanthroline-5,6-dione Arene Complexes". International Journal of Molecular Sciences (2022): https://doi.org/10.3390/ijms232113594.
    10.3390/ijms232113594
  15. Cinthia Alves Barroco; Patricia H. Brito; Ilda Santos-Sanches; Alexandra Fernandes. "Phylogenetic analysis and accessory genome diversity reveal insight into the evolutionary history of Streptococcus dysgalactiae". Frontiers in Microbiology 13 (2022): https://novaresearch.unl.pt/en/publications/b54d8326-ee09-465d-adf2-e8a64535ed2b.
    10.3389/fmicb.2022.952110
  16. Cinthia Alves Barroco; Ana Maria Nunes Botelho; Marco Antonio Américo; Sérgio Eduardo Longo Fracalanzza; António P. Alves de Matos; Márcia Aparecida Guimaraes; Bernadete Teixeira Ferreira-Carvalho; Agnes Marie Sá Figueiredo; Alexandra Fernandes. "Assessing in vivo and in vitro biofilm development by Streptococcus dysgalactiae subsp. dysgalactiae using a murine model of catheter-associated biofilm and human keratinocyte cell". Frontiers in Cellular and Infection Microbiology 12 (2022): https://novaresearch.unl.pt/en/publications/cd0003de-8d6a-46f6-9271-98a45b30eed3.
    10.3389/fcimb.2022.874694
  17. Ana P. Rodrigo; Ana Lopes; Ricardo Pereira; Sandra I. Anjo; Bruno Manadas; Ana R. Grosso; Pedro V. Baptista; Alexandra R. Fernandes; Pedro M. Costa. "Endogenous Fluorescent Proteins in the Mucus of an Intertidal Polychaeta: Clues for Biotechnology". Marine Drugs 20 4 (2022): 224-224. https://doi.org/10.3390/md20040224.
    10.3390/md20040224
  18. Cinthia Alves Barroco; Lorenzo Rivas García; Alexandra Fernandes; P. V. Baptista. "Light Triggered Enhancement of Antibiotic Efficacy in Biofilm Elimination Mediated by Gold-Silver Alloy Nanoparticles". Frontiers in Microbiology 13 (2022): 1-15. https://novaresearch.unl.pt/en/publications/0bcfd107-8452-4c8b-aa82-54f8c63e0d40.
    10.3389/fmicb.2022.841124
  19. Inês C. B. Martins; Andreia Forte; Hermínio P. Diogo; Luís R. Raposo; Pedro V. Baptista; Alexandra R. Fernandes; Luís C. Branco; M. Teresa Duarte. "A solvent-free strategy to prepare amorphous salts of folic acid with enhanced solubility and cell permeability". Chemistry–Methods (2022): https://doi.org/10.1002/cmtd.202100104.
    10.1002/cmtd.202100104
  20. Hadi Amiri Rudbari; Arezoo Saadati; Mahnaz Aryaeifar; Olivier Blacque; José V. Cuevas-Vicario; Rui Cabral; Luís R Raposo; Alexandra Fernandes. "Platinum(II) and Copper(II) complexes of asymmetric halogen-substituted [NN'O] ligands". Bioorganic Chemistry 119 (2022): 1-22. https://novaresearch.unl.pt/en/publications/387e1d3c-be89-436f-af4f-1a3d3e86767e.
    10.1016/j.bioorg.2021.105556
  21. Oscar Lenis Rojas; Beatriz Carvalho; Rui Cabral; Margarida Silva; Sofia Friães; Catarina Roma-Rodrigues; Marta S. H. Meireles; et al. "Manganese(I) tricarbonyl complexes as potential anticancer agents". JBIC Journal of Biological Inorganic Chemistry 27 1 (2022): 49-64. https://novaresearch.unl.pt/en/publications/c9cc0922-3c73-4761-9b42-c6554b4dba46.
    10.1007/s00775-021-01910-7
  22. Margarida Ferreira-Silva; Ana Catarina Faria da Silva; Manuela Carvalheiro; Sandra Simões; H. Susana Marinho; Paulo Marcelino; Maria Celeste Campos; et al. "Quercetin Liposomal Nanoformulation for Ischemia and Reperfusion Injury Treatment". Pharmaceutics (2022): https://www.mdpi.com/1999-4923/14/1/104.
    10.3390/pharmaceutics14010104
  23. Hadi Amiri Rudbari; Nazanin Kordestani; Jose V. Cuevas-Vicario; Min Zhou; Thomas Efferth; Isabel Correia; Tanja Schirmeister; et al. "Investigation of the influence of chirality and halogen atoms on the anticancer activity of enantiopure palladium(ii) complexes derived from chiral amino-alcohol Schiff bases and 2-picolylamine". New Journal of Chemistry 46 14 (2022): 6470-6483. https://doi.org/10.1039/D2NJ00321J.
    10.1039/D2NJ00321J
  24. Andrea Pinto; Catarina Roma-Rodrigues; Jas S. Ward; Rakesh Puttreddy; Kari Rissanen; Pedro V. Baptista; Alexandra R. Fernandes; João Carlos Lima; Laura Rodríguez. "Aggregation versus Biological Activity in Gold(I) Complexes. An Unexplored Concept". Inorganic Chemistry (2021): https://doi.org/10.1021/acs.inorgchem.1c02359.
    10.1021/acs.inorgchem.1c02359
  25. Bilal Abdulmawjood; Beatriz Costa; Catarina Roma-Rodrigues; Pedro V. Baptista; Alexandra R. Fernandes. "Genetic Biomarkers in Chronic Myeloid Leukemia: What Have We Learned So Far?". International Journal of Molecular Sciences 22 22 (2021): 12516-12516. https://doi.org/10.3390/ijms222212516.
    10.3390/ijms222212516
  26. Ana R. Jesus; Luís R. Raposo; Mário R. C. Soromenho; Daniela A. S. Agostinho; José M. S. S. Esperança; Pedro V. Baptista; Alexandra R. Fernandes; Patrícia M. Reis. "New Non-Toxic N-alkyl Cholinium-Based Ionic Liquids as Excipients to Improve the Solubility of Poorly Water-Soluble Drugs". Symmetry (2021): https://doi.org/10.3390/sym13112053.
    10.3390/sym13112053
  27. Joanna Palion-Gazda; André Luz; Luís R Raposo; Katarzyna Choroba; Jacek Nycz; Alina Bienko; Agnieszka Lewinska; et al. "Vanadium(IV) Complexes with Methyl-Substituted 8-Hydroxyquinolines: Catalytic Potential in the Oxidation of Hydrocarbons and Alcohols with Peroxides and Biological Activity". Molecules (2021): https://www.mdpi.com/1420-3049/26/21/6364.
    10.3390/molecules26216364
  28. Oscar A. Lenis-Rojas; Sandra Cordeiro; Marta Horta-Meireles; Jhonathan Angel Araujo Fernández; Sabela Fernández Vila; Juan Andrés Rubiolo; Pablo Cabezas-Sainz; et al. "N-Heterocyclic Carbene Iron Complexes as Anticancer Agents: In Vitro and In Vivo Biological Studies". Molecules 26 18 (2021): 5535-5535. https://doi.org/10.3390/molecules26185535.
    10.3390/molecules26185535
  29. Oscar Lenis-Rojas; Catarina Roma-Rodrigues; Alexandra Fernandes; Andreia Carvalho; Sandra Cordeiro; Jorge Guerra-Varela; Laura Sánchez; et al. "Evaluation of the In Vitro and In Vivo Efficacy of Ruthenium Polypyridyl Compounds against Breast Cancer". International Journal of Molecular Sciences 22 16 (2021): 8916-8916. https://doi.org/10.3390/ijms22168916.
    10.3390/ijms22168916
  30. Cinthia Alves Barroco; João Caço; Catarina Roma-Rodrigues; Alexandra Fernandes; Ricardo Bexiga; Manuela Oliveira; Lélia Chambel; et al. "New Insights on Streptococcus dysgalactiae subsp. dysgalactiae Isolates". Frontiers in Microbiology 12 (2021): https://novaresearch.unl.pt/en/publications/bc4f3d1a-3f32-403d-a308-823b9d481a28.
    10.3389/fmicb.2021.686413
  31. Oscar A. Lenis-Rojas; Rui Cabral; Beatriz Carvalho; Sofia Friães; Catarina Roma-Rodrigues; Jhonathan A. A. Fernández; Sabela F. Vila; et al. "Triazole-Based Half-Sandwich Ruthenium(II) Compounds: From In Vitro Antiproliferative Potential to In Vivo Toxicity Evaluation". Inorganic Chemistry 60 11 (2021): 8011-8026. https://doi.org/10.1021/acs.inorgchem.1c00527.
    10.1021/acs.inorgchem.1c00527
  32. Margarida Ferreira-Silva; Catarina Faria-Silva; Pedro Viana Baptista; Eduarda Fernandes; Alexandra Ramos Fernandes; Maria Luísa Corvo. "Drug delivery nanosystems targeted to hepatic ischemia and reperfusion injury". Drug Delivery and Translational Research (2021): https://doi.org/10.1007/s13346-021-00915-8.
    10.1007/s13346-021-00915-8
  33. Margarida Ferreira-Silva; Catarina Faria-Silva; Pedro Viana Baptista; Eduarda Fernandes; Alexandra Ramos Fernandes; Maria Luísa Corvo. "Liposomal Nanosystems in Rheumatoid Arthritis". Pharmaceutics 13 4 (2021): 454-454. https://doi.org/10.3390/pharmaceutics13040454.
    10.3390/pharmaceutics13040454
  34. Francisco Reigosa-Chamorro; Luís R. Raposo; Paula Munín-Cruz; M. Teresa Pereira; Catarina Roma-Rodrigues; Pedro V. Baptista; Alexandra R. Fernandes; José M. Vila. "In Vitro and In Vivo Effect of Palladacycles: Targeting A2780 Ovarian Carcinoma Cells and Modulation of Angiogenesis". Inorganic Chemistry (2021): https://doi.org/10.1021/acs.inorgchem.0c03763.
    10.1021/acs.inorgchem.0c03763
  35. Oscar A. Lenis-Rojas; M. Paula Robalo; Ana Isabel Tomaz; Alexandra R. Fernandes; Catarina Roma-Rodrigues; Ricardo G. Teixeira; Fernanda Marques; et al. "Half-Sandwich Ru(p-cymene) Compounds with Diphosphanes: In Vitro and In Vivo Evaluation As Potential Anticancer Metallodrugs". Inorganic Chemistry (2021): https://doi.org/10.1021/acs.inorgchem.0c02768.
    10.1021/acs.inorgchem.0c02768
  36. Choroba, Katarzyna; Machura, Barbara; Szlapa-Kula, Agata; Malecki, Jan G.; Raposo, Luis; Roma-Rodrigues, Catarina; Cordeiro, Sandra; Baptista, Pedro V.; Fernandes, Alexandra R.. "Square planar Au(III), Pt(II) and Cu(II) complexes with quinoline-substituted 2,2':6',2''-terpyridine ligands: from in vitro to in vivo biological properties". European Journal of Medicinal Chemistry (2021): 113404. http://dx.doi.org/10.1016/j.ejmech.2021.113404.
    10.1016/j.ejmech.2021.113404
  37. José L. Quiles; Catarina Roma-Rodrigues; Luís R Raposo; María D. Navarro-Hortal; Jose M. Romero-Márquez; Adelaida Esteban-Muñoz; Alfonso Varela-López; et al. "Rosa x hybrida extracts with dual actions: Antiproliferative effects against tumour cells and inhibitor of Alzheimer disease". Food and Chemical Toxicology 149 (2021): https://novaresearch.unl.pt/en/publications/1dd08105-b75e-4004-aff7-1afa1ee9e732.
    10.1016/j.fct.2021.112018
  38. Ana P. Rodrigo; Ana R. Grosso; Pedro V. Baptista; Alexandra R. Fernandes; Pedro M. Costa. "A Transcriptomic Approach to the Recruitment of Venom Proteins in a Marine Annelid". Toxins 13 2 (2021): 97-97. https://doi.org/10.3390/toxins13020097.
    10.3390/toxins13020097
  39. Ana P. Rodrigo; Vera M. Mendes; Bruno Manadas; Ana R. Grosso; António P. Alves de Matos; Pedro V. Baptista; Pedro M. Costa; Alexandra R. Fernandes. "Specific Antiproliferative Properties of Proteinaceous Toxin Secretions from the Marine Annelid Eulalia sp. onto Ovarian Cancer Cells". Marine Drugs (2021): https://doi.org/10.3390/md19010031.
    10.3390/md19010031
  40. Luís R. Raposo; Ana Silva; Dário Silva; Catarina Roma-Rodrigues; Margarida Espadinha; Pedro V. Baptista; Maria M.M. Santos; Alexandra R. Fernandes. "Exploiting the antiproliferative potential of spiropyrazoline oxindoles in a human ovarian cancer cell line". Bioorganic & Medicinal Chemistry 30 (2021): 115880-115880. https://doi.org/10.1016/j.bmc.2020.115880.
    10.1016/j.bmc.2020.115880
  41. Pedro Pedrosa; Pedro V. Baptista; Alexandra R. Fernandes; Mauro Guerra. "Benchtop X-ray fluorescence imaging as a tool to study gold nanoparticle penetration in 3D cancer spheroids". RSC Advances (2021): https://doi.org/10.1039/D1RA05446E.
    10.1039/D1RA05446E
  42. Nazanin Kordestani; Hadi Amiri Rudbari; Alexandra R. Fernandes; Luís R. Raposo; André Luz; Pedro V. Baptista; Giuseppe Bruno; et al. "Copper(ii) complexes with tridentate halogen-substituted Schiff base ligands: synthesis, crystal structures and investigating the effect of halogenation, leaving groups and ligand flexibility on antiproliferative activities". Dalton Transactions (2021): https://doi.org/10.1039/D0DT03962D.
    10.1039/D0DT03962D
  43. Diogo Sequeira; Pedro V. Baptista; Ruben Valente; M. Fátima M. Piedade; M. Helena Garcia; Tânia S. Morais; Alexandra R. Fernandes. "Cu(i) complexes as new antiproliferative agents against sensitive and doxorubicin resistant colorectal cancer cells: synthesis, characterization, and mechanisms of action". Dalton Transactions (2021): https://doi.org/10.1039/D0DT03566A.
    10.1039/D0DT03566A
  44. Catarina Roma-Rodrigues; Inês Pombo; Alexandra R. Fernandes; Pedro V. Baptista. "Hyperthermia Induced by Gold Nanoparticles and Visible Light Photothermy Combined with Chemotherapy to Tackle Doxorubicin Sensitive and Resistant Colorectal Tumor 3D Spheroids". International Journal of Molecular Sciences 21 21 (2020): 8017-8017. https://doi.org/10.3390/ijms21218017.
    10.3390/ijms21218017
  45. Lilianne Beola; Laura Asín; Catarina Roma-Rodrigues; Yilian Fernandez-Afonso; Raluca M. Fratila; David Serantes; Sergiu Ruta; et al. "The intracellular number of magnetic nanoparticles modulates the apoptotic death pathway after magnetic hyperthermia treatment". ACS Applied Materials and Interfaces 12 39 (2020): 43474-43487. https://novaresearch.unl.pt/en/publications/58ee5e02-b4e8-4d36-a618-a3d36901a6a7.
    10.1021/acsami.0c12900
  46. Daniela Ferreira; David Fontinha; Catarina Martins; David Pires; Alexandra R. Fernandes; Pedro V. Baptista. "Gold Nanoparticles for Vectorization of Nucleic Acids for Cancer Therapeutics". Molecules (2020): https://doi.org/10.3390/molecules25153489.
    10.3390/molecules25153489
  47. Daniela Alves Ferreira; Luísa M. D. R. S. Martins; Alexandra R. Fernandes; Marta Martins. "A Tale of Two Ends: Repurposing Metallic Compounds from Anti-Tumour Agents to Effective Antibacterial Activity". Antibiotics 9 6 (2020): 321-321. https://doi.org/10.3390/antibiotics9060321.
    10.3390/antibiotics9060321
  48. Rita B. Restani; Rita F. Pires; Pedro V. Baptista; Alexandra R. Fernandes; Teresa Casimiro; Vasco D. B. Bonifácio; Ana Aguiar-Ricardo. "Nano-in-Micro Sildenafil Dry Powder Formulations for the Treatment of Pulmonary Arterial Hypertension Disorders: The Synergic Effect of POxylated Polyurea Dendrimers, PLGA, and Cholesterol". Particle & Particle Systems Characterization (2020): 1900447-1900447. https://doi.org/10.1002/ppsc.201900447.
    10.1002/ppsc.201900447
  49. Beatriz Oliveira; Bruno Veigas; Alexandra R. Fernandes; Hugo Águas; Rodrigo Martins; Elvira Fortunato; Pedro Viana Baptista. "Fast Prototyping Microfluidics: Integrating Droplet Digital Lamp for Absolute Quantification of Cancer Biomarkers". Sensors (2020): https://doi.org/10.3390/s20061624.
    10.3390/s20061624
  50. Roma-Rodrigues, Catarina; Rivas-García, Lorenzo; Baptista, Pedro V.; Fernandes, Alexandra R.. "Gene Therapy in Cancer Treatment: Why Go Nano?". Pharmaceutics 12 3 (2020): 233. http://dx.doi.org/10.3390/pharmaceutics12030233.
    10.3390/pharmaceutics12030233
  51. Nazanin Kordestani; Hadi Amiri Rudbari; Alexandra R. Fernandes; Luís R. Raposo; Pedro V. Baptista; Daniela Ferreira; Giuseppe Bruno; et al. "Antiproliferative Activities of Diimine-Based Mixed Ligand Copper(II) Complexes". ACS Combinatorial Science 22 2 (2020): 89-99. https://doi.org/10.1021/acscombsci.9b00202.
    10.1021/acscombsci.9b00202
  52. Katarzyna Choroba; Luis R. Raposo; Joanna Palion-Gazda; Ewa Malicka; Karol Erfurt; Barbara Machura; Alexandra R. Fernandes. "In vitro antiproliferative effect of vanadium complexes bearing 8-hydroxyquinoline-based ligands – the substituent effect". Dalton Transactions (2020): https://doi.org/10.1039/D0DT01017K.
    10.1039/D0DT01017K
  53. Fernandes, A.R.; Mendonça-Martins, I.; Santos, M.F.A.; Raposo, L.R.; Mendes, R.; Marques, J.; Romão, C.C.; et al. "Improving the Anti-inflammatory Response via Gold Nanoparticle Vectorization of CO-Releasing Molecules". ACS Biomaterials Science and Engineering 6 2 (2020): 1090-1101. http://www.scopus.com/inward/record.url?eid=2-s2.0-85079071744&partnerID=MN8TOARS.
    10.1021/acsbiomaterials.9b01936
  54. Busila, M.; Tabacaru, A.; Mussat, V.; Vasile, B.S.; Neasu, I.A.; Pinheiro, T.; Roma-Rodrigues, C.; et al. "Size-Dependent Biological Activities of Fluorescent Organosilane-Modified Zinc Oxide Nanoparticles". Journal of biomedical nanotechnology 16 2 (2020): 137-152. http://www.scopus.com/inward/record.url?eid=2-s2.0-85083071724&partnerID=MN8TOARS.
    10.1166/jbn.2020.2882
  55. Roma-Rodrigues, C.; Malta, G.; Peixoto, D.; Ferreira, L.M.; Baptista, P.V.; Fernandes, A.R.; Branco, P.S.. "Synthesis of new hetero-arylidene-9(10H)-anthrone derivatives and their biological evaluation". Bioorganic Chemistry 99 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85083360964&partnerID=MN8TOARS.
    10.1016/j.bioorg.2020.103849
  56. João Franco Machado; Diogo Sequeira; Fernanda Marques; M. Fátima M. Piedade; Maria J. Villa de Brito; M. Helena Garcia; Alexandra R. Fernandes; Tânia S. Morais. "New copper(i) complexes selective for prostate cancer cells". Dalton Transactions (2020): https://doi.org/10.1039/D0DT02157A.
    10.1039/D0DT02157A
  57. Pedro Pedrosa; M. Luísa Corvo; Margarida Ferreira-Silva; Pedro Martins; Manuela Colla Carvalheiro; Pedro M. Costa; Carla Martins; et al. "Targeting Cancer Resistance via Multifunctional Gold Nanoparticles". International Journal of Molecular Sciences (2019): https://doi.org/10.3390/ijms20215510.
    10.3390/ijms20215510
  58. Das K; Datta A; Frontera A; Wen YS; Roma-Rodrigues C; Raposo LR; Fernandes AR; Hung CH. "Zn(II) and Co(II) derivatives anchored with scorpionate precursor: Antiproliferative evaluation in human cancer cell lines.". Journal of inorganic biochemistry (2019): http://europepmc.org/abstract/med/31698185.
    10.1016/j.jinorgbio.2019.110881
  59. Catarina Roma-Rodrigues; Alexandra R. Fernandes; Pedro V. Baptista. "

    Counteracting the effect of leukemia exosomes by antiangiogenic gold nanoparticles

    ". International Journal of Nanomedicine (2019): https://doi.org/10.2147/IJN.S215711.
    10.2147/IJN.S215711
  60. Roma-Rodrigues C; Pombo I; Raposo L; Pedrosa P; Fernandes AR; Baptista PV. "Nanotheranostics Targeting the Tumor Microenvironment.". Frontiers in bioengineering and biotechnology (2019): http://europepmc.org/abstract/med/31475143.
    10.3389/fbioe.2019.00197
  61. Almeida J; Roma-Rodrigues C; Mahmoud AG; Guedes da Silva MFC; Pombeiro AJL; Martins LMDRS; Baptista PV; Fernandes AR. "Structural characterization and biological properties of silver(I) tris(pyrazolyl)methane sulfonate.". Journal of inorganic biochemistry (2019): http://europepmc.org/abstract/med/31357066.
    10.1016/j.jinorgbio.2019.110789
  62. Veigas B; Matias A; Calmeiro T; Fortunato E; Fernandes AR; Baptista PV. "Antibody modified gold nanoparticles for fast colorimetric screening of rheumatoid arthritis.". The Analyst (2019): http://europepmc.org/abstract/med/31070614.
    10.1039/c9an00319c
  63. Santos MM; Raposo LR; Carrera GVSM; Costa A; Dionísio M; Baptista PV; Fernandes AR; Branco LC. "Ionic Liquids and Salts from Ibuprofen as Promising Innovative Formulations of an Old Drug.". ChemMedChem (2019): http://europepmc.org/abstract/med/30735308.
    10.1002/cmdc.201900040
  64. Jesus AR; Soromenho MRC; Raposo LR; Esperança JMSS; Baptista PV; Fernandes AR; Reis PM. "Enhancement of water solubility of poorly water-soluble drugs by new biocompatible N-acetyl amino acid N-alkyl cholinium-based ionic liquids.". European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V (2019): http://europepmc.org/abstract/med/30836180.
    10.1016/j.ejpb.2019.03.004
  65. Catarina Roma-Rodrigues; Rita Mendes; P. V. Baptista; Alexandra Fernandes. "Targeting Tumor Microenvironment for Cancer Therapy". International Journal of Molecular Sciences (2019): http://www.mdpi.com/1422-0067/20/4/840.
    10.3390/ijms20040840
  66. Alves-Barroco C; Roma-Rodrigues C; Balasubramanian N; Guimarães MA; Ferreira-Carvalho BT; Muthukumaran J; Nunes D; et al. "Biofilm development and computational screening for new putative inhibitors of a homolog of the regulatory protein BrpA in Streptococcus dysgalactiae subsp. dysgalactiae.". International journal of medical microbiology : IJMM (2019): http://europepmc.org/abstract/med/30799091.
    10.1016/j.ijmm.2019.02.001
  67. Kourmentza C; Araujo D; Sevrin C; Roma-Rodriques C; Lia Ferreira J; Freitas F; Dionisio M; et al. "Occurrence of non-toxic bioemulsifiers during polyhydroxyalkanoate production by Pseudomonas strains valorizing crude glycerol by-product.". Bioresource technology (2019): http://europepmc.org/abstract/med/30798087.
    10.1016/j.biortech.2019.02.066
  68. Cinthia Alves-Barroco; Catarina Roma-Rodrigues; Luís R. Raposo; Catarina Brás; Mário Diniz; João Caço; Pedro M. Costa; et al. "Streptococcus dysgalactiae subsp. dysgalactiae isolated from milk of the bovine udder as emerging pathogens: In vitro and in vivo infection of human cells and zebrafish as biological models". MicrobiologyOpen 8 1 (2019): e00623-e00623. https://doi.org/10.1002/mbo3.623.
    10.1002/mbo3.623
  69. Oliveira H; Roma-Rodrigues C; Santos A; Veigas B; Brás N; Faria A; Calhau C; et al. "GLUT1 and GLUT3 involvement in anthocyanin gastric transport- Nanobased targeted approach.". Scientific reports (2019): http://europepmc.org/abstract/med/30692585.
    10.1038/s41598-018-37283-2
  70. Fialho, Letícia; Araújo, Diana; Alves, Vitor D.; Roma-Rodrigues, Catarina; Baptista, Pedro V.; Fernandes, Alexandra R.; Freitas, Filomena; et al. "Cation-mediated gelation of the fucose-rich polysaccharide FucoPol: preparation and characterization of hydrogel beads and their cytotoxicity assessment". (2019): http://hdl.handle.net/10362/93177.
    https://doi.org/10.1080/00914037.2019.1695205
  71. Sutradhar, Manas; Alegria, Elisabete; Ferretti, Francesco; Raposo, Luís R; Guedes Da Silva, M. Fátima C.; Baptista, Pedro; Fernandes, Alexandra; Pombeiro, Armando. "Antiproliferative activity of heterometallic sodium and potassium-dioxidovanadium(V) polymers". (2019): http://hdl.handle.net/10400.21/10589.
    10.1016/j.jinorgbio.2019.110811
  72. Catarina Bravo; M. Paula Robalo; Fernanda Marques; Alexandra R. Fernandes; Diogo A. Sequeira; M. Fátima M. Piedade; M. Helena Garcia; Maria J. Villa de Brito; Tânia S. Morais. "First heterobimetallic Cu(i)–dppf complexes designed for anticancer applications: synthesis, structural characterization and cytotoxicity". New Journal of Chemistry (2019): https://doi.org/10.1039/C9NJ02068C.
    10.1039/C9NJ02068C
  73. Katarzyna Choroba; Barbara Machura; Slawomir Kula; Luis R. Raposo; Alexandra R. Fernandes; Rafal Kruszynski; Karol Erfurt; et al. "Copper(ii) complexes with 2,2':6',2''-terpyridine, 2,6-di(thiazol-2-yl)pyridine and 2,6-di(pyrazin-2-yl)pyridine substituted with quinolines. Synthesis, structure, antiproliferative activity, and catalytic activity in the oxidation of alkanes and alcohols with peroxides". Dalton Transactions (2019): https://doi.org/10.1039/C9DT01922G.
    10.1039/C9DT01922G
  74. Katarzyna Choroba; Barbara Machura; Luis R. Raposo; Jan G. Malecki; Slawomir Kula; Michal Pajak; Karol Erfurt; Anna M. Maron; Alexandra R. Fernandes. "Platinum(ii) complexes showing high cytotoxicity toward A2780 ovarian carcinoma cells". Dalton Transactions (2019): https://doi.org/10.1039/C9DT02894C.
    10.1039/C9DT02894C
  75. Das, K.; Datta, A.; Massera, C.; Roma-Rodrigues, C.; Barroso, M.; Baptista, P.V.; Fernandes, A.R.. "Structural aspects of a trimetallic Cu II derivative: cytotoxicity and anti-proliferative activity on human cancer cell lines". Journal of Coordination Chemistry 72 5-7 (2019): 920-940. http://www.scopus.com/inward/record.url?eid=2-s2.0-85065565968&partnerID=MN8TOARS.
    10.1080/00958972.2019.1597973
  76. Raquel Vinhas; Alexandra Lourenço; Susana Santos; Marcos Lemos; Patrícia Ribeiro; Aida Botelho de Sousa; Pedro V. Baptista; Alexandra R. Fernandes. "A novel BCR-ABL1 mutation in a patient with Philadelphia chromosome-positive B-cell acute lymphoblastic leukemia". OncoTargets and Therapy (2018): https://doi.org/10.2147/OTT.S177019.
    10.2147/OTT.S177019
  77. Rita B. Restani; Rita F. Pires; Anna Tolmatcheva; Rita Cabral; Pedro V. Baptista; Alexandra R. Fernandes; Teresa Casimiro; et al. "POxylated Dendrimer-Based Nano-in-Micro Dry Powder Formulations for Inhalation Chemotherapy". ChemistryOpen 7 10 (2018): 772-779. https://doi.org/10.1002/open.201800093.
    10.1002/open.201800093
  78. Rita B. Restani; Rita F. Pires; Anna Tolmatcheva; Rita Cabral; Pedro V. Baptista; Alexandra R. Fernandes; Teresa Casimiro; Vasco D. B. Bonifácio; Ana Aguiar-Ricardo. "Cover Feature: POxylated Dendrimer-Based Nano-in-Micro Dry Powder Formulations for Inhalation Chemotherapy (ChemistryOpen 10/2018)". ChemistryOpen 7 10 (2018): 751-751. https://doi.org/10.1002/open.201800165.
    10.1002/open.201800165
  79. Noora Svahn; Artur J. Moro; Catarina Roma-Rodrigues; Rakesh Puttreddy; Kari Rissanen; Pedro V. Baptista; Alexandra R. Fernandes; João Carlos Lima; Laura Rodríguez. "Front Cover: The Important Role of the Nuclearity, Rigidity, and Solubility of Phosphane Ligands in the Biological Activity of Gold(I) Complexes (Chem. Eur. J. 55/2018)". Chemistry - A European Journal (2018): https://doi.org/10.1002/chem.201804177.
    10.1002/chem.201804177
  80. Sutradhar M; Fernandes AR; Paradinha F; Rijo P; Garcia C; Roma-Rodrigues C; Pombeiro AJL; Charmier AJ. "A new Cu(II)-O-Carvacrotinate complex: Synthesis, characterization and biological activity.". Journal of inorganic biochemistry (2018): http://europepmc.org/abstract/med/30342353.
    10.1016/j.jinorgbio.2018.09.018
  81. Vinhas R; Lourenço A; Santos S; Ribeiro P; Silva M; de Sousa AB; Baptista PV; Fernandes AR. "A double Philadelphia chromosome-positive chronic myeloid leukemia patient, co-expressing P210BCR-ABL1 and P195BCR-ABL1 isoforms.". Haematologica (2018): http://europepmc.org/abstract/med/30093395.
    10.3324/haematol.2018.192534
  82. Ribeiro, A. P. C.; Anbu, S.; Alegria, Elisabete; Fernandes, Alexandra; Baptista, Pedro; Mendes, R.; Matias, A. S.; et al. "Evaluation of cell toxicity and DNA and protein binding of green synthesized silver nanoparticles". (2018): http://hdl.handle.net/10400.21/9121.
    10.1016/j.biopha.2018.02.069
  83. Pedrosa, Pedro; Mendes, Rita; Cabral, Rita; Martins, Luísa M. D. R. S.; Baptista, Pedro V.; Fernandes, Alexandra R.; DCV - Departamento de Ciências da Vida; et al. "Combination of chemotherapy and Au-nanoparticle photothermy in the visible light to tackle doxorubicin resistance in cancer cells". Scientific Reports 8 1 (2018): http://www.scopus.com/inward/record.url?scp=85050817470&partnerID=8YFLogxK.
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  84. Lenis-Rojas, Oscar A.; Robalo, Maria Paula; Tomaz, Ana Isabel; Carvalho, Andreia; Fernandes, Alexandra R.; Marques, Fernanda; Folgueira, Mónica; et al. "Ru-II(p-cymene) compounds as effective and selective anticancer candidates with no toxicity in vivo". (2018): http://hdl.handle.net/10400.21/8964.
    10.1021/acs.inorgchem.8b01270
  85. Gomes, S.E.; Pereira, D.M.; Roma-Rodrigues, C.; Fernandes, A.R.; Borralho, P.M.; Rodrigues, C.M.P.. "Convergence of MIR-143 overexpression, oxidative stress and cell death in HCT116 human colon cancer cells". PLoS ONE 13 1 (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85040986423&partnerID=MN8TOARS.
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  86. Baptista, P.V.; McCusker, M.P.; Carvalho, A.; Ferreira, D.A.; Mohan, N.M.; Martins, M.; Fernandes, A.R.; et al. "Nano-strategies to fight multidrug resistant bacteria-"A Battle of the Titans"". Frontiers in Microbiology 9 JUL (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85049384316&partnerID=MN8TOARS.
    10.3389/fmicb.2018.01441
  87. Subhabrata Sen; Chandramohan Bathula; Catarina Rodrigues; Alexandra Fernandes; Jyoti Chauhan. "Synthesis of tetrahydro-1H-indolo[2, 3-b]pyrrolo[3, 2-c]quinolones via intramolecular oxidative ring rearrangement of tetrahydro-ß-carbolines and their biological evaluation". New Journal of Chemistry (2018): https://doi.org/10.1039%2Fc7nj04616b.
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  88. Alves, P. U.; Vinhas, R.; Fernandes, A. R.; Birol, S. Z.; Trabzon, L.; Bernacka-Wojcik, I.; Igreja, R.; et al. "Multifunctional microfluidic chip for optical nanoprobe based RNA detection - application to Chronic Myeloid Leukemia". Sci Rep 8 1 (2018): 381-381. https://www.ncbi.nlm.nih.gov/pubmed/29321602.
    10.1038/s41598-017-18725-9
  89. Svahn, N.; Moro, A.J.; Roma-Rodrigues, C.; Puttreddy, R.; Rissanen, K.; Baptista, P.V.; Fernandes, A.R.; Lima, J.C.; Rodríguez, L.. "The Important Role of the Nuclearity, Rigidity, and Solubility of Phosphane Ligands in the Biological Activity of Gold(I) Complexes". Chemistry (Weinheim an der Bergstrasse, Germany) 24 55 (2018): 14654-14667. http://www.scopus.com/inward/record.url?eid=2-s2.0-85054065949&partnerID=MN8TOARS.
    10.1002/chem.201804176
  90. Maron, A.; Czerwinska, K.; Machura, B.; Raposo, L.; Roma-Rodrigues, C.; Fernandes, A.R.; Malecki, J.G.; et al. "Spectroscopy, electrochemistry and antiproliferative properties of Au(iii), Pt(ii) and Cu(ii) complexes bearing modified 2,2':6',2''-terpyridine ligands". Dalton Transactions 47 18 (2018): 6444-6463. http://www.scopus.com/inward/record.url?eid=2-s2.0-85046839407&partnerID=MN8TOARS.
    10.1039/c8dt00558c
  91. Peixoto, D.; Figueiredo, M.; Malta, G.; Roma-Rodrigues, C.; Baptista, P.V.; Fernandes, A.R.; Barroso, S.; et al. "Synthesis, Cytotoxicity Evaluation in Human Cell Lines and in Vitro DNA Interaction of a Hetero-Arylidene-9(10H)-Anthrone". European Journal of Organic Chemistry 2018 4 (2018): 545-549. http://www.scopus.com/inward/record.url?eid=2-s2.0-85041287294&partnerID=MN8TOARS.
    10.1002/ejoc.201701500
  92. Morais, T.S.; Jousseaume, Y.; Piedade, M.F.M.; Roma-Rodrigues, C.; Fernandes, A.R.; Marques, F.; Villa De Brito, M.J.; Helena Garcia, M.. "Important cytotoxic and cytostatic effects of new copper(i)-phosphane compounds with N,N, N,O and N,S bidentate ligands". Dalton Transactions 47 23 (2018): 7819-7829. http://www.scopus.com/inward/record.url?eid=2-s2.0-85048401535&partnerID=MN8TOARS.
    10.1039/c8dt01653d
  93. Das, K.; Beyene, B.B.; Datta, A.; Garribba, E.; Roma-Rodrigues, C.; Silva, A.; Fernandes, A.R.; Hung, C.-H.. "EPR and electrochemical interpretation of bispyrazolylacetate anchored Ni(ii) and Mn(ii) complexes: Cytotoxicity and anti-proliferative activity towards human cancer cell lines". New Journal of Chemistry 42 11 (2018): 9126-9139. http://www.scopus.com/inward/record.url?eid=2-s2.0-85047986859&partnerID=MN8TOARS.
    10.1039/c8nj01033a
  94. Fernandes, A.R.; Jesus, J.; Martins, P.; Figueiredo, S.; Rosa, D.; Martins, L.M.R.D.R.S.; Corvo, M.L.; et al. "Multifunctional gold-nanoparticles: A nanovectorization tool for the targeted delivery of novel chemotherapeutic agents". Journal of Controlled Release 245 (2017): 52-61. http://www.scopus.com/inward/record.url?eid=2-s2.0-84999008906&partnerID=MN8TOARS.
    10.1016/j.jconrel.2016.11.021
  95. Lenis-Rojas, O.A.; Roma-Rodrigues, C.; Fernandes, A.R.; Marques, F.; Pérez-Fernández, D.; Guerra-Varela, J.; Sánchez, L.; et al. "Dinuclear RuII(bipy)2Derivatives: Structural, Biological, and in Vivo Zebrafish Toxicity Evaluation". Inorganic Chemistry 56 12 (2017): 7127-7144. http://www.scopus.com/inward/record.url?eid=2-s2.0-85020908951&partnerID=MN8TOARS.
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  96. Tavares, M.; Cabral, R.P.; Costa, C.; Martins, P.; Fernandes, A.R.; Casimiro, T.; Aguiar-Ricardo, A.. "Development of PLGA dry powder microparticles by supercritical CO2-assisted spray-drying for potential vaccine delivery to the lungs". Journal of Supercritical Fluids 128 (2017): 235-243. http://www.scopus.com/inward/record.url?eid=2-s2.0-85020706929&partnerID=MN8TOARS.
    10.1016/j.supflu.2017.06.004
  97. Raposo, L.R.; Roma-Rodrigues, C.; Jesus, J.; Martins, L.M.D.R.S.; Pombeiro, A.J.; Baptista, P.V.; Fernandes, A.R.. "Targeting canine mammary tumours via gold nanoparticles functionalized with promising Co(II) and Zn(II) compounds". Veterinary and Comparative Oncology (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85011706279&partnerID=MN8TOARS.
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  98. Sutradhar, M.; Rajeshwari; Roy Barman, T.; Fernandes, A.R.; Paradinha, F.; Roma-Rodrigues, C.; Guedes da Silva, M.F.C.; Pombeiro, A.J.L.. "Mixed ligand aroylhydrazone and N-donor heterocyclic Lewis base Cu(II) complexes as potential antiproliferative agents". Journal of Inorganic Biochemistry 175 (2017): 267-275. http://www.scopus.com/inward/record.url?eid=2-s2.0-85028731781&partnerID=MN8TOARS.
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  99. Roma-Rodrigues, C.; Raposo, L.R.; Cabral, R.; Paradinha, F.; Baptista, P.V.; Fernandes, A.R.. "Tumor microenvironment modulation via gold nanoparticles targeting malicious exosomes: Implications for cancer diagnostics and therapy". International Journal of Molecular Sciences 18 1 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85009892134&partnerID=MN8TOARS.
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  100. Vinhas, R.; Cordeiro, M.; Pedrosa, P.; Fernandes, A.R.; Baptista, P.V.. "Current trends in molecular diagnostics of chronic myeloid leukemia". Leukemia and Lymphoma 58 8 (2017): 1791-1804. http://www.scopus.com/inward/record.url?eid=2-s2.0-85002410324&partnerID=MN8TOARS.
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  101. do Nascimento-Neto, L. G.; Cabral, M. G.; Carneiro, R. F.; Silva, Z.; Arruda, F. V. S.; Nagano, C. S.; Fernandes, A. R.; et al. "Halilectin-3, a lectin from the marine sponge Haliclona caerulea, induces apoptosis and autophagy in human breast cancer MCF7 cells through caspase-9 pathway and LC3-II protein expression". Anticancer Agents Med Chem (2017): https://www.ncbi.nlm.nih.gov/pubmed/29141557.
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  102. Cordeiro, M.; Carvalho, L.; Silva, J.; Saúde, L.; Fernandes, A.R.; Baptista, P.V.. "Gold nanobeacons for tracking gene silencing in zebrafish". Nanomaterials 7 1 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85009776467&partnerID=MN8TOARS.
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  103. Vinhas, R.; Fernandes, A.R.; Baptista, P.V.. "Gold Nanoparticles for BCR-ABL1 Gene Silencing: Improving Tyrosine Kinase Inhibitor Efficacy in Chronic Myeloid Leukemia". Molecular Therapy - Nucleic Acids 7 (2017): 408-416. http://www.scopus.com/inward/record.url?eid=2-s2.0-85020493223&partnerID=MN8TOARS.
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  104. Roma-Rodrigues, C.; Pereira, F.; Alves de Matos, A.P.; Fernandes, M.; Baptista, P.V.; Fernandes, A.R.. "Smuggling gold nanoparticles across cell types – A new role for exosomes in gene silencing". Nanomedicine: Nanotechnology, Biology, and Medicine 13 4 (2017): 1389-1398. http://www.scopus.com/inward/record.url?eid=2-s2.0-85016940939&partnerID=MN8TOARS.
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  164. Fernandes, A.R.; Sá-Correia, I.. "Transcription patterns of PMA1 and PMA2 genes and activity of plasma membrane H+-ATPase in Saccharomyces cerevisiae during diauxic growth and stationary phase". Yeast 20 3 (2003): 207-219. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037326499&partnerID=MN8TOARS.
    10.1002/yea.957
  165. Simões, T.; Teixeira, M.C.; Fernandes, A.R.; Sá-Correia, I.. "Adaptation of Saccharomyces cerevisiae to the herbicide 2,4-dichlorophenoxyacetic acid, mediated by Msn2p- and Msn4p-regulated genes: Important role of SPI1". Applied and Environmental Microbiology 69 7 (2003): 4019-4028. http://www.scopus.com/inward/record.url?eid=2-s2.0-17544401667&partnerID=MN8TOARS.
    10.1128/AEM.69.7.4019-4028.2003
  166. Fernandes, A.R.; Sá-Correia, I.. "The activity of plasma membrane H+-ATPase is strongly stimulated during Saccharomyces cerevisiae adaptation to growth under high copper stress, accompanying intracellular acidification". Yeast 18 6 (2001): 511-512. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035048535&partnerID=MN8TOARS.
    10.1002/yea.702
  167. Tenreiro, S.; Fernandes, A.R.; Sá-Correia, I.. "Transcriptional activation of FLR1 gene during Saccharomyces cerevisiae adaptation to growth with benomyl: Role of Yap1p and Pdr3p". Biochemical and Biophysical Research Communications 280 1 (2001): 216-222. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034805930&partnerID=MN8TOARS.
    10.1006/bbrc.2000.4100
  168. Fernandes, A.R.; Prieto, M.; Sá-Correia, I.. "Modification of plasma membrane lipid order and H+-ATPase activity as part of the response of Saccharomyces cerevisiae to cultivation under mild and high copper stress". Archives of Microbiology 173 4 (2000): 262-268. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034119202&partnerID=MN8TOARS.
    10.1007/s002030000138
  169. Abdallah, B.M.; Simões, T.; Fernandes, A.R.; Strauss, J.; Seiboth, B.; Sá-Correia, I.; Kubicek, C.P.. "Glucose does not activate the plasma-membrane-bound H+-ATPase but affects pmaA transcript abundance in Aspergillus nidulans". Archives of Microbiology 174 5 (2000): 340-345. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033714945&partnerID=MN8TOARS.
    10.1007/s002030000212
  170. Labbé, S.; Peña, M.M.O.; Fernandes, A.R.; Thiele, D.J.. "A copper-sensing transcription factor regulates iron uptake genes in Schizosaccharomyces pombe". Journal of Biological Chemistry 274 51 (1999): 36252-36260. http://www.scopus.com/inward/record.url?eid=2-s2.0-0040437349&partnerID=MN8TOARS.
    10.1074/jbc.274.51.36252
  171. Fernandes, A.R.; Sá-Correia, I.. "Comparative effects of Saccharomyces cerevisiae cultivation under copper stress on the activity and kinetic parameters of plasma-membrane-bound H+- ATPases PMA1 and PMA2". Archives of Microbiology 171 4 (1999): 273-278. http://www.scopus.com/inward/record.url?eid=2-s2.0-0344178092&partnerID=MN8TOARS.
    10.1007/s002030050710
  172. Fernandes, A.R.; Peixoto, F.P.; Sá-Correia, I.. "Activation of the H+-ATPase in the plasma membrane of cells of Saccharomyces cerevisiae grown under mild copper stress". Archives of Microbiology 171 1 (1998): 6-12. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032455608&partnerID=MN8TOARS.
    10.1007/s002030050671

Other

Other output
  1. Short Lecture 4 "Evaluation of antiproliferative and anti-angiogenic activity of an ethanolic extract of Helichrysum odoratissimum (L.) Sweet against skin cancer". 2022. D. Twilley; D. Meyer; L. Langhansova; L. J. Mcgaw; B. Madikizela; Catarina Roma-Rodrigues; P. V. Baptista; Alexandra Fernandes; N. Lall. https://novaresearch.unl.pt/en/publications/369d10eb-2e6f-43a9-84a5-990255c67228.
    10.1055/s-0042-1758900
  2. Editorial. Rational drug design of metal complexes for cancer therapy. 2022. Tânia S. Morais; Alexandra Fernandes; P. V. Baptista; Dinorah Gambino. https://novaresearch.unl.pt/en/publications/d4d2de75-8b92-4145-a0f6-9c8c6693380c.
    10.3389/fchem.2022.1035274
  3. The genetic susceptibility linking preterm birth and periodontal disease a review. 2021. Joana Couceiroa; Ana Rita Grosso; P. V. Baptista; Jose J. Mendes; Alexandra Fernandes; Alexandre Quintas. https://novaresearch.unl.pt/en/publications/80f84bb2-7e12-419f-bbf0-feffa7116f8e.
  4. Genetic predisposition for aggressive behaviour related with dopamine and serotonin pathways - an overview. 2021. Cathy Paulino; Alexandra Fernandes; P. V. Baptista; Cristina Soeiro; Ana Rita Grosso; Alexandre Quintas. https://novaresearch.unl.pt/en/publications/e707ed89-b184-4bfe-9944-9d9c2bb74e15.
    10.1080/07853890.2021.1897426
  5. Correction to: Nano-in-Micro Sildenafil Dry Powder Formulations for the Treatment of Pulmonary Arterial Hypertension Disorders: The Synergic Effect of POxylated Polyurea Dendrimers, PLGA, and Cholesterol (Part. Part. Syst. Charact, (2020), 37, (1900447), 10.1002/ppsc.19000447). 2020. Rita B. Restani; Márcia T. Tavares; Rita F. Pires; P. V. Baptista; Alexandra Fernandes; Teresa Casimiro; Vasco D. B. Bonifácio; Ana Aguiar-Ricardo. https://novaresearch.unl.pt/en/publications/8a201829-bff5-44ac-9e88-3b9745e399b3.
    10.1002/ppsc.202000251
  6. 3D cell culture model for drug screening purposes. Case study for Cytosmart - Lux3 FL. 2020. Roma-Rodrigues, Catarina; Raposo, Luís R; Baptista, Pedro Viana; Alexandra R Fernandes. https://cytosmart.com/resources/case-studies/3-d-cell-culture-model-drug-screening-purposes.
  7. New lessons from ancient life: marine invertebrates as a source of new drugs. 2019. A. P. Rodrigo; C. Martins; L. Tanoeiro; M. Casaca; A. R. Lopes; A. Jorge Parola; A. P. Matos; et al. https://novaresearch.unl.pt/en/publications/388a1a5a-44fc-46a7-8cb5-bdb178d0d7ee.
    10.1080/07853890.2018.1561901
  8. Gold Nanoparticles in Molecular Diagnostics and Molecular Therapeutics. 2017. Ana S. Matias; Fábio F. Carlos; P. Pedrosa; Alexandra R. Fernandes; Pedro V. Baptista. https://doi.org/10.1007%2F978-3-319-63790-7_16.
    10.1007/978-3-319-63790-7_16
Activities

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2023 - Current Au-NANOconjugates for combinatory therapeutics against PDAC - bridging the translation gap between 3D and PDOs
Co-supervisor
 PHD in Biotecnology (PhD)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2023 - Current Gold4Exomarkers: Modulation of exosome biomarkers of drug resistance via gold nanoconjugates
Supervisor
 PhD in Biotechnology (PhD)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2021 - Current Nanoheaters – Localized hyperthermia for precise gene delivery
Co-supervisor of Daniela Ferreira
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2021 - Current Novel ionic liquids as targeted therapy drugs for lung cancer
Co-supervisor of Dário Valezim Silva
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2021 - Current From proteins to Bacteria: a multidisciplinar approach for the rational development of new anti-biofilm and antibacterial agents
Co-supervisor of João Paquete Ferreira
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2019 - Current Towards the molecular mechanism underlying the association between preterm birth and periodontal disease
Co-supervisor of Joana Couceiro
 Biologia (PhD)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2019 - Current Towards the molecular mechanism underlying resistance in Chronic Myeloid leukemia: new therapies
Supervisor of Bilal Rabah Qasim Abdulmawjood
Centro Interuniversitário de História das Ciências e da Tecnologia, Portugal
2022/03/01 - 2026/02/27 (Gold4TME): Modulation of tumor microenvironment via combinatorial gold nanomedicines
Supervisor
 Biologia (PhD)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2023 - 2023 Avaliação do potencial antiproliferativo de complexos de cobre (II) em células tumorais
Supervisor
 Genética Molecular e Biomedicina (Master)
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2018 - 2023 Transdermal delivery systems based on natural polymeric biomaterials
Co-supervisor of Diana Filipa Vieira Araújo
 Engenharia Química (PhD)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2022 - 2022 Caracterização da composição de exossomas excretados a partir de modelos celulares 2D e 3D derivados de células de carcinoma colorretal sensíveis ou resistentes à doxorrubicina
Supervisor
 Genética Molecular e Biomedicina (Master)
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2022 - 2022 Modulation of Tumor Microenvironment Towards Cancer Therapy
Supervisor
 Biotecnologia (Master)
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2022 - 2022 Nova metodologia para o diagnóstico e monitorização do adenocarcinoma ductal pancreático
Co-supervisor
 Genética Molecular e Biomedicina (Master)
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2022 - 2022 Novas estratégias para combater a resistência a múltiplos fármacos na leucemia mieloide crónica
Supervisor
 Genética Molecular e Biomedicina (Master)
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2022 - 2022 Estudo do efeito antiproliferativo de complexos de vanádio (IV) em células tumorais
Supervisor
 Genética Molecular e Biomedicina (Master)
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2022 - 2022 Molecular Phenotyping of Prostate Cancer MicroenvironmentI, With Emphasis on Aspartoacylase Expression in Fibroblasts
Co-supervisor
 Genética Molecular e Biomedicina (Master)
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2022 - 2022 Characterization of doxorubicin-sensitive and -resistant colorectal cancer cell spheroids
Supervisor
 Genética Molecular e Biomedicina (Master)
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2022 - 2022 Studying susceptibility genetic variants and circulating biomarkers in early onset colorectal cancer
Co-supervisor
 Genética Molecular e Biomedicina (Master)
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2022 - 2022 The role of GSH signaling in mitophagy induced by reactive oxygen species: potential target for neuroprotection in stroke?
Co-supervisor
 Genética Molecular e Biomedicina (Master)
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2018 - 2022 Targeting liver ischemia reperfusion injury: nanoformulations for gene silencing
Co-supervisor of Ana Margarida Ferreira da Silva
i3Du (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2014 - 2022 Unraveling the host specificity within pyogenic streptococci".
Supervisor of Cinthia Barroco
 Biologia (PhD)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2016 - 2021/02/26 De pigmentos e toxinas: uma abordagem integradora ao potencial biotecnológico de um poliqueta marinho
Co-supervisor of Ana Rodrigo
 Ambiente (PhD)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2021 - 2021 Avaliação de novos complexos metálicos de Ru(II) e Mn(I) como agentes antiproliferativos em células tumorais
Supervisor
 Bioquímica (Master)
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2021 - 2021 Validação de novos compostos metálicos para o tratamento de cancro
Supervisor
 Genética Molecular e Biomedicina (Master)
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2020 - 2020 Steroid-BODIPY theranostics: Receptor-mediated cell uptake and applications in cancer Diagnostics and therapy
Supervisor
 Bioquímica para a Saúde (Master)
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2010 - 2020 >52 Master Thesis in cancer therapy
Supervisor
2019 - 2019 Avaliação de compostos de Cu(I) como novos agentes quimioterapêuticos
Supervisor
 Bioquímica (Master)
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2014 - 2018 Gold Nanoparticles for nanotherasnostic in Leukaemia addressing CML
Co-supervisor of Raquel Patricia Gomes Silvestre Vinhas.
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2017 - 2017 Synthesis and biological evaluation of novel anti-cancer agents
Supervisor
 Genética Molecular e Biomedicina (Master)
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2017 - 2017 Gold Nanoparticles to Tackle Drug Resistance in Cancer
Supervisor
 Biociências Moleculares (PhD)
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2017 - 2017 Gene Espression Analysis in Cardiac and Adipose Derived Fibroblasts: potential influence of origin and in vitro culture
Co-supervisor
 Engenharia Biomédica (Master)
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2016 - 2016 Combining Gene Therapy, Hyperthermia and Chemotherapy: An Opportunity To Revolutionize Cancer Treatment
Supervisor
 Genética Molecular e Biomedicina (Master)
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2015 - 2015 Caracterização Biológica de Complexos de Ruténio como Potenciais Agentes Anti-tumorais
Supervisor
 Genética Molecular e Biomedicina (Master)
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2015 - 2015 Assessment of a novel Cu (II) complex as a potential anticancer agent
Supervisor
 Genética Molecular e Biomedicina (Master)
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2015 - 2015 Blocking tumor exosome release using nanovectorization systems
Supervisor
 Genética Molecular e Biomedicina (Master)
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2015 - 2015 Novos genes no diagnóstico genético de miocardiopatia hipertrófica
Supervisor
 Engenharia Biotecnológica (Master)
Universidade de Aveiro Instituto Superior de Contabilidade e Administração, Portugal
2014 - 2014 Unraveling the host specificity within Streptococcus dysgalactiae subsp. dysgalactiae
Supervisor
 Biologia (PhD)
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2014 - 2014 Gold nanoparticulate systems for new anticancer compounds delivery
Supervisor
 Genética Molecular e Biomedicina (Master)
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2014 - 2014 Monotherapy and combined therapy of new potential antitumor compounds: antiproliferative activities and biological targets
Supervisor
 Genética Molecular e Biomedicina (Master)
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2014 - 2014 Biological Evalutation of Chlorogold Complexs as Potential Anti-Tumoral Compounds: Unraveling Mechanisms of Action
Supervisor
 Genética Molecular e Biomedicina (Master)
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2013 - 2013 Validação do potencial anti-tumoral de um composto de cobre e identificação dos seus alvos biológicos
Supervisor
 Genética Molecular e Biomedicina (Master)
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2013 - 2013 Caracterização do potencial anti-tumoral e identificação de alvos biológicos de um complexo de cobre com terpiridinas
Supervisor
 Genética Molecular e Biomedicina (Master)
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2011 - 2011 Transcriptome and proteome profiling of canine mammary tumors: dog as a genetic model for unrevealing mammary cancer molecular signatures
Supervisor
 Biologia (PhD)
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2020/10/09 - Current III International Conference NOVAHealth Chronic Disease and Infection "Infection, Cancer and Global Health" (2020/10/09 - 2020/10/09)
Conference (Co-organisor)
 Universidade NOVA de Lisboa, Portugal
2023/06/22 - 2023/06/23 2nd Meeting of the Portuguese Network on Extracellular Vesicles (PNEV) (2023/06/22 - 2023/06/23)
Conference (Member of the Organising Committee)
2022/10/22 - 2022/10/22 Microbiota and Health - V International Conference NOVAHealth Chronic Disease and Infection (2022/10/22 - 2022/10/22)
Conference (Member of the Organising Committee)
 Universidade NOVA de Lisboa, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2022 Endothelial cell-specific phosphatase VE-PTP in regulation of endothelial biology
President of the jury
 Filipa Viviana Rocha Martinez Oliveira (Master)
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2022 Remote Ischemic Conditioning (RIC) against ischemic stroke: functional validation of conditioned plasma in human cells
President of the jury
 Catarina Cardoso Pires (Master)
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2022 Carbon monoxide-mediated pro-regenerative and non-inflammatory microglial phagocytosis: towards clearance of dead neurons
President of the jury
 Catarina Guerreiro Simões (Master)
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2020 Stereological study on organelle distribution in human oocytes at metaphase-I
President of the jury
 Sofia Peres Coelho (Master)
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2020 microRNAs as Biomarkers of Cancer Drug Resistance
President of the jury
 Mónica Gabriela dos Santos Honrado (Master)
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2019 T cell polarization influences the development of IBD-associated neoplasia
President of the jury
 Ana Sofia de Castro Brandão (Master)
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2019 Developing gene-edited models to study mis-splicing in Hypertrophic Cardiomyopathy
President of the jury
 Marta Isabel Brandão Furtado (Master)
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2019 Identification of biomarkers of colorectal cancer risk and metastasis: targeting early onset cancer
President of the jury
 Inês Rodrigues Borges Ferreira (Master)
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2019 Neuronal-Intraepithelial Lymphocyte Interactions at the Intestinal Mucosa
President of the jury
 Raquel Maia de Carvalhal Soares (Master)
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2019 Polylactic acid 3D scaffolds as platforms for local-delivery and hyperthermia applications in bone tumours
President of the jury
 Ana Sofia Domingues Santos Saraiva (Master)
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2019 Characterization and Modulation of the Renin-Angiotensin System in Diabetic Retinopathy
President of the jury
 Brigite Ladeira Cabrita (Master)
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2019 Antioxidant - loaded mucoadhesive nanoparticles for eye drug delivery: new strategy to reduce the oxidative stress
President of the jury
 Sandra Isabel Nunes Cordeiro (Master)
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2019 Gene therapy mediated by glycopolymers-based nanocarriers in combination with chemotherapeutic drugs as a potential therapeutic strategy for hepatocellular carcinoma
(Thesis) Main arguer
 Daniela Filipa Domingues Santo (PhD)
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2018 Diseño y propiedades de compuestos heterolépticos derivados de Ru (?6-pcimeno)
(Thesis) Arguer
 Jorge Lado Sanjurjo (PhD)
2018 Functional Characterization of Variants of Unknown Significance in Familial Breast Cancer
President of the jury
 Rita Adubeiro Lourenço (Master)
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2018 Novel fluorescent cell-based sensors for detection of viral pathogens
President of the jury
 Carolina da Silva Carreira (Master)
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2018 Oral Cancer: from genomic landscape to tumor immunobiology
President of the jury
 Inês Martins Tomás (Master)
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2018 Unveiling mechanotransduction during collective cell migration
President of the jury
 Isabela Corina Santos Fortunato (Master)
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2018 Alternative Splicing of EXOC7 in Colorectal Cancer Development
President of the jury
 Daniela Maria Grou Ramalho (Master)
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2018 Uncovering the role of blood vessels during spinal cord regeneration in zebrafish
President of the jury
 Mariana Antas Rebocho da Costa (Master)
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2017 miRNA-143 and miRNA-145 Modulation in colorectal cancer: from anticancer activity to drug sensitization
Thesis Member
 Sofia Estevão Gomes (PhD)
2017 Diseño e estudio de compuestos de rutenio con actividad biológica
(Thesis) Main arguer
 Oscar Armando Lenis-Rojas (PhD)
2017 Identifying novel chemotypes against breast cancer: Design, synthesis and biological evaluation
(Thesis) Arguer
 Chandramohan Bathula (PhD)
2017 Interplay of Endoplasmatic Reticulum Stress and Autophagy in Parkinson’s Disease
President of the jury
 Carolina Leça de Azevedo Pereira Tavares (Master)
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2017 Characterization of a chromosome rearrangement associated with cardiopathy and autism
President of the jury
 Sara Melo Dias (Master)
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2016 Biophysical and biological studies of ternary copper(ii) complexes anchored polyethyleneimine – in vitro approach for the search of polymeric anticancer drugs
(Thesis) Arguer
 Kumar Sugumar (PhD)
2016 The role of alpha2,3 and alpha2,6 sialylation in functional aspects of dendritic cells
Thesis Member
 Hélio Santos Crespo (PhD)
2016 Development of Field Effect sensors for gene expression analysis: Application to cancer diagnosis
Thesis Member
 Bruno Miguel Ribeiro Veigas (PhD)
2015 Design and Synthesis of small molecule modulators of p53
(Thesis) Arguer
 Carlos Jorge Azevedo Costa Pinheiro. (PhD)
2015 Engineered MRI nanoprobes based on superparamagnetic iron oxide nanoparticles
Thesis Member
 Susana Palma (PhD)
2015 ?Identifying new regulators of the actin cytoskeleton in endothelial tip cells
President of the jury
 Aida Andreia Pereira Pires Lima (Master)
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2015 Molecular targeting of proteins by homocysteine: implications in familial and clinical hypercholesterolemia
President of the jury
 Ana Rita Marques Lemos (Master)
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2014 Base Genética da Hipercolesterolemia Familiar em Portugal
(Thesis) Arguer
 Ana Catarina dos Santos Alves. (PhD)
2014 Gold Nanoparticles for the detection of DNA adducts as biomarkers od exposure to acrylamide
Thesis Member
 Miguel Ângelo Rodrigues Larguinho (PhD)
2014 Bioprocess engineering of induced pluripotent stem cell for application in cell therapy and pre-clinic research
(Thesis) Main arguer
 Nuno Miguel Moura Espinha (Master)
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Conference scientific committee

Conference name Conference host
2023/10/14 - 2023/10/14 COVID-19: the contribution of NOVA - Lessons learned, perspectives for the future Universidade de Lisboa
1997 - 2021 > 100 poster in international meeting -

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2019/07 - 2019/09 Animal experimentation Course - FELASA Type B Curso de Experimentação animal (Curso de Especialização Tecnológica) Universidade de Lisboa Faculdade de Farmácia, Portugal

Evaluation committee

Activity description
Role 		Institution / Organization Funding entity
2017 - 2024 Czech Science Foundation, National Science Center Poland
Evaluator
2019 - 2023 Bolsas Doutoramento FCT/MCTES
Evaluator
2019 - 2023 Evaluation of FCT.IP R&D Projects 2017-2022 (Final Reports) - Biotechnology Area
Evaluator
 Fundação para a Ciência e a Tecnologia, Portugal Fundação para a Ciência e a Tecnologia
2018 - 2023 The Royal Society, UK
Evaluator
2017 - 2020 UK Welcome Trust
Evaluator
2015 - 2020 ANR - Agence Nationale de la Researche
Evaluator
2019 - 2019 Georg Forster Research Fellowships for Experienced Researchers, Alexander von Humboldt-Stiftung Foundation
Evaluator
2015 - 2016 Austrian Science Fund I projects
Evaluator
Distinctions

Other distinction

2013 Prémio Fundação Everis - Heargenetics SA
2002 Award of best poster presentation