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My research focuses on translating stem cell- and gene-based strategies into clinically relevant therapies for neurodegenerative diseases. I am an Assistant Researcher at the Centre for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, supported by PRR and EU Next Generation funding through the CiNTech project (2023–2026), where I work on advanced medical therapies and pharmaceutical innovation. I hold a PhD in Biomedical Sciences from the University of Porto (FCT fellowship) and completed advanced international training at the Stem Cell Institute in Minneapolis (USA). During my postdoctoral work at CIBB-UC, I specialized in gene therapy and viral vectors, contributing to translational projects targeting Machado–Joseph Disease (MJD). I have since established my own research line, leading a small team and securing competitive funding as PI (€140K) for innovative neuronal reprogramming and gene-silencing approaches with direct clinical relevance, and I have applied for the La Caixa Foundation Health Grant. At the European level, I am a core member of large collaborative consortia (CinTech, GeneT, ERDERA, GeneH, GCure; >€30M), contributing to RNA screening platforms, regulatory frameworks for advanced therapies, and industry collaborations (e.g., Bluepharma, Roche). Within CiNTech, I lead the evaluation of therapeutic RNAs in injectable drug platforms. I have authored 45 publications, including 11 peer-reviewed papers since 2020, with strong citation impact (73% published in the top 25% most cited journals in the field). I have delivered 10 invited lectures, supervised undergraduate, Master’s, and PhD students, and co-organized international scientific meetings. My work has been internationally recognized through awards (e.g., ESCI Young Investigator Award) and selection for competitive innovation programs (EIT Health Top Female Founders). I actively promote inclusive and responsible science through leadership roles in ALBA Network and GreenLabs@CIBB. Living with chronic health conditions and having taken maternity leave has strengthened my resilience and organizational capacity, which I ask to be considered when assessing my academic trajectory.
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Identificação

Identificação pessoal

Nome completo
Catarina Sofia Oliveira Miranda

Nomes de citação

  • Miranda, Catarina
  • Miranda, CO
  • Catarina Oliveira Miranda
  • Miranda, Catarina Oliveira
  • Miranda, C
  • Oliveira Miranda, Catarina

Identificadores de autor

Ciência ID
0115-D868-90A4
ORCID iD
0000-0001-5241-8108
Google Scholar ID
https://scholar.google.com/citations?hl=pt-PT&user=-CgL-XkAAAAJ&scilu=&scisig=AMD79ooAAAAAXlURRQ5Z-5nPExgVdpE3cfxO1LGjBbD8&gmla=AJsN-F5C-oZVbEb_W3j0Z9A8R_yJ2lwdSGOfaxWvqlDP3ntcyUAMlou19MpWsf3LFllTYOWmzH48f_tH_ZAv8DL8mgYGiaUVYXXrHeJH8yKMUd1zCwMduU9LZzLd0Xc
Researcher Id
L-3549-2014
Scopus Author Id
54389618400

Endereços de correio eletrónico

  • miranda.catarina@gmail.com (Profissional)
  • csmiranda@cnc.uc.pt (Profissional)

Domínios de atuação

  • Ciências Médicas e da Saúde - Medicina Básica - Neurociências
  • Ciências Médicas e da Saúde - Biotecnologia Médica - Tecnologias que envolvem a Manipulação de Células,Tecidos,Órgãos ou todo o Organismo
  • Ciências Médicas e da Saúde - Medicina Clínica - Neurologia Clínica
  • Ciências Naturais - Ciências Biológicas - Biologia Celular
  • Ciências Médicas e da Saúde - Biotecnologia Médica - Diagnóstico e Terapias de Base Genética
  • Ciências Médicas e da Saúde - Medicina Básica - Genética Humana
  • Ciências Médicas e da Saúde - Biotecnologia Médica - Diagnóstico e Terapias de Base Genética
  • Ciências Naturais - Ciências Biológicas
  • Ciências Naturais - Ciências Biológicas - Biologia Molecular
  • Ciências Naturais - Ciências Biológicas - Biologia das Ciências do Comportamento
  • Ciências Médicas e da Saúde - Medicina Básica - Neurociências
  • Ciências Médicas e da Saúde - Biotecnologia Médica - Tecnologias que envolvem a Manipulação de Células,Tecidos,Órgãos ou todo o Organismo
  • Ciências Médicas e da Saúde - Medicina Básica - Toxicologia
  • Ciências Médicas e da Saúde - Biotecnologia Médica - Biotecnologia Aplicada à Saúde
  • Ciências Médicas e da Saúde - Biotecnologia Médica - Diagnóstico e Terapias de Base Genética

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Francês Utilizador independente (B2) Utilizador independente (B1) Utilizador elementar (A2) Utilizador proficiente (C1)
Espanhol; Castelhano Utilizador independente (B2) Utilizador independente (B1) Utilizador elementar (A1) Utilizador proficiente (C1)
Português (Idioma materno)
Formação
Grau Classificação
2019
Concluído
 “Mesenchymal stem cells for Machado-Joseph disease therapy” (Pós-doutoramento)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 NA
2013/08/21 - 2014/01/05
Concluído
 Maternity leave and High-risk pregnancy (Outros)
Maternidade Bissaya Barreto, Portugal
 NA
2012
Concluído
 Biomedical Sciences (Doutoramento)
Institute for Biomedical Sciences Abel Salazar (ICBAS), University of Porto (UP), Portugal, Portugal
"“Bone Marrow-Derived Mesenchymal Stromal Cell Transplantation: An Add-on Option for Krabbe’s Disease.”" (TESE/DISSERTAÇÃO)
 Approved Unanimity with Distinction
2009
Concluído
 Animal Experimentation Course - FELASA C (Outros)
Federation of European Laboratory Animal Science Associations, Reino Unido
 Accreditation
2006/01/05 - 2006/03/10
Concluído
 Multipotent Adult Stem Cells Course (Outros)
University of Minnesota Twin Cities Stem Cell Institute, Estados Unidos
2005
Concluído
 Cellular Biology (Mestrado)
Faculty for Sciences and Technology from University of Coimbra (FCTUC), University of Coimbra (UC), Portugal, Portugal
"Expression of Adult Progenitor Stem Cell Markers in the Male Germ Epithelium" (TESE/DISSERTAÇÃO)
 Very Good (17-20, out of 20).
2003
Concluído
 Biology (Licenciatura)
Faculty for Sciences and Technology from University of Coimbra (FCTUC), University of Coimbra (UC), Portugal, Portugal
"“Human Reproduction Technologies and Criopreservation of Human Gametes”" (TESE/DISSERTAÇÃO)
 Final grade of 15 (out of 20).
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2023/09 - Atual Assistente de Investigação (carreira) (Investigação) Universidade de Coimbra, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2019/01/04 - 2023/08/31 Investigador (Investigação) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2013/02/01 - 2018/01/15 Pós-doutorado (Investigação) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2012/05/15 - 2012/12/31 Investigador (Investigação) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2011/04/01 - 2012/03/31 Investigador (Investigação) Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2007/04/01 - 2011/03/31 Investigador (Investigação) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2006/04/01 - 2007/03/31 Investigador (Investigação) Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2006/01/02 - 2006/02/28 Investigador visitante (Investigação) University of Minnesota Stem Cell Institute, Estados Unidos
University of Minnesota Stem Cell Institute, Estados Unidos
2004/03/01 - 2005/12/23 Investigador (Investigação) Universidade do Porto Faculdade de Medicina, Portugal
2002/10/01 - 2003/06/30 Estagiário de Investigação (Investigação) Hospitais da Universidade de Coimbra, Portugal
Hospitais da Universidade de Coimbra, Portugal

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2013/08/21 - 2014/01/05 Maternity leave and High-risk pregnancy Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Projetos

Bolsa

Designação Financiadores
2025/01/01 - 2027/12/31 Fighting Alzheimer’s disease using tailor-made multivalent copolymers (250k €)
COMPETE2030-FEDER-00840500
Investigador
2026/01/01 - 2027/06/30 Harnessing optimized Poly(ester amide)s for easing Parkinson's (60K €)
2024.13699.PEX
Investigador
2025/02 - 2026/02 Direct Glia Reprogramming and Mutant Ataxin-3 Silencing as a New Combined Therapeutic Strategy to Treat Spinocerebellar Ataxia Type-3 - a Proof-of-Principle Study (50K €)
29068
Investigador responsável
AFM-Téléthon
Em curso
2023 - 2024 Direct Conversion of Astrocytes into Cerebellar Neurons as an Innovative Treatment for Spinocerebellar Ataxia Type-3 - 50K€
2022.06127.PTDC
Investigador responsável
Fundação para a Ciência e a Tecnologia
2023 - 2024 From bedside-to-bench biomarker discovery: on the road to a clinical trial for Machado-Joseph Disease (50K))
2022.06118.PTDC
Investigador
Fundação para a Ciência e a Tecnologia, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2023 - 2024 Pre-clinical evaluation of the brain-targeting AAV-PHP.eB encoding cholesterol hydroxylase CYP46A1 as a therapeutic strategy for spinocerebellar ataxia type 3 – towards the understanding of the neuroprotective mechanism (50K€))
2022.04788.PTDC
Investigador
Fundação para a Ciência e a Tecnologia, Portugal
 Fundação para a Ciência e a Tecnologia
2022 - 2023 (Less)PlasticBrain: Bio Replacing Plasticizers - Impact in the Human Brain Development - 20K euros
NA
Investigador responsável
Banco Santander Portugal
2022 - 2023 Dextran-PCL-based nerve guidance conduits 3D printed for nerve regeneration (100K€))
CI22-00190
Investigador
Centro de la Fundació Caixa Castelló
2021/08/01 - 2022/03/31 Multiomics approach for studying mitochondrial dysfunction in aging to harness stem cell therapy (20K €)
ND
Investigador responsável
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Japan Agency for Medical Research and Development (AMED)
Em curso
2018/07 - 2021/07 Role of microRNA deregulation in Machado-Joseph Disease: On the development of a microRNA-based therapeutic strategy
PTDC/MED-NEU/32309/2017
Investigador
Fundação para a Ciência e a Tecnologia
2017 - 2020 BrainHealth 2020 - Detecção Precoce, Neuro-modulação e Terapias Avançadas para Neuropatologias.
CENTRO-01-0145-FEDER-000008
Investigador
Funding Agency: Centro2020 - Programa Operacional Centro 2020 (FEDER/FSE) (BrainHealth 2020 CENTRO-01-0145-FEDER-000008)
2013/02/01 - 2019 Mesenchymal Stem Cells for Machado-Joseph Disease
SFRH/BPD/87732/2012
Bolseiro de Pós-Doutoramento
Fundação para a Ciência e a Tecnologia
2016/01 - 2018/12 Gene repair and repression strategies to alleviate Machado-Joseph disease
Provided by PTCRIS: 138667
 Fundação para a Ciência e a Tecnologia
2015/01 - 2017/12 CNC. IBILI
Provided by PTCRIS: 147358
Investigador
Fundação para a Ciência e a Tecnologia
2012/01 - 2015/07 Dissecting the pathogenesis of Machado-Joseph disease in a new human disease model derived from induced pluripotent stem cells
Provided by PTCRIS: 116512
Bolseiro de Investigação
Fundação para a Ciência e a Tecnologia
2011/02 - 2014/03 Dissecting nerve regeneration and the neuritogenic activity of TTR.
Provided by PTCRIS: 111761
Bolseiro de Investigação
Fundação para a Ciência e a Tecnologia
2007 - 2011 Evaluation of Cellular Therapy in Leukodystrophies with Peripheral Nervous System Demyelination
SFRH/BD/29768/2006
Bolseiro de Doutoramento
Fundação para a Ciência e a Tecnologia
2007/11 - 2010/10 Search for the molecular basis of transthyretin involvement in the biology of the nervous system.
grant.Provided by PTCRIS: 64437
Investigador
Fundação para a Ciência e a Tecnologia
2006/10 - 2007/03 Towards the establishment of cell-based therapy for repairing cardiac-injury: characterization, purification and functional analysis of potential therapeutic-beneficial cell-subsets.
PTDC/SAU-OSM/68473/2006
Investigador
Fundação para a Ciência e a Tecnologia
2005 - 2007 Evaluation of Cellular Therapy in Leukodystrophies with Peripheral Nervous System Demyelination
N/A
Bolseiro de Investigação
Association Européenne contre les Leucodystrophies

Projeto

Designação Financiadores
2021/01/01 - 2025/12/31 Centro de Inovação em Biomedicina e Biotecnologia - Laboratório Associado
LA/P/0058/2020
10.54499/LA/P/0058/2020
Universidade de Coimbra, Portugal

Universidade Nova de Lisboa Laboratório de Instrumentação Engenharia Biomédica e Física da Radiação, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2023/09 - 2025/12 CiNTech: Polo Tecnológico de Inovação, Translação e Industrialização de Medicamentos Injetáveis Complexos (29,9M)
02/C05-i01.01/2022.PC644865576-00000005
Investigador
European Union
Em curso
2019 - 2021 MESENCHYMAL STEM CELLS FOR MACHADO-JOSEPH DISEASE THERAPY
position 6 of NT CNC 2018.01-35
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Universidade de Coimbra Centro de Neurociências e Biologia Celular
Concluído
2016/04/01 - 2019/12/31 Estratégias de reparação e repressão génica para tratar a doença de Machado-Joseph
PTDC/NEU-NMC/0084/2014
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2011/01/01 - 2012/12/31 Projecto Estratégico - LA 2 - 2011-2012
PEst-C/SAU/LA0002/2011
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Instituto Nacional de Engenharia Biomédica, Portugal
Fundação para a Ciência e a Tecnologia
Concluído

Outro

Designação Financiadores
2025/01/01 - Atual G-Cure - from Gene to Cure; Grant agreement ID: 101186929 (€ 2.5M)
101186929
Investigador
European Commission
Em curso
2025/01/01 - Atual GeneH – Building Bridges in Gene Therapy – From Research to Patients, European Union–funded project (ID: 101186939) – (€ 4.9M)
101186939
Investigador
European Union
Em curso
2024/09/01 - Atual Rare Diseases Research Alliance (ERDERA), Technology Accelerator - RNA design, manufacturing, large-scale production, and bio distribution - European Union–funded (ref: 101156595)
101156595
Investigador
European Union
Em curso
Produções

Publicações

Artigo em conferência
  1. Miranda, CO. "I Barros, D Gonzaga, DD Lobo, SM Lopes, I Martins, A Silva, LP Almeida, CO Miranda. “The guardians of balance: mesenchymal stem cells as a promising strategy to restore blood-brain barrier integrity”. Paper presented in 30st Annual Meeting of the European Society of Gene & Cell Therapy – ESGCT 2023, Brussels, Belgium, October 2023. HUMAN GENE THERAPY 35 (3-4), A196-A196.". 2023.
  2. Barros, Ines; Gonzaga, Daniela; Lobo, Diana; Nobre, Rui Jorge; Martins, Ines; Silva, Antonio; Duarte, Sonia; De Almeida, Luis Pereira; Miranda, Catarina Oliveira. "ALTERED TIGHT JUNCTION-ASSOCIATED PROTEINS SUBCELLULAR LOCALIZATION IN MACHADO-JOSEPH DISEASE/SPINOCEREBELLAR ATAXIA TYPE 3". 2022.
  3. Oliveira Miranda, C.; Duarte Lobo, D.; Jorge Nobre, R.; Gonzaga, D.; Ines Barros, M.; Ines Martins, M.; Castelhano, J.; et al. "Blood-brain barrier (BBB) disruption is a shared feature for several neurodegenerative diseases". 2021.
  4. Nobre, Rui Jorge; Saraiva, Joana; Santana, Magda; Fusco, Clelia; Paixao, Susana; Miranda, Catarina; Petrella, Lorena; et al. "Allele-Specific AAV-Based Silencing of Mutant Ataxin-3 Alleviates Neuropathology and Motor Deficits in Spinocerebellar Ataxia Type 3". 2020.
  5. Diana Lobo; Rui Nobre; Catarina Miranda; Dina Pereira; João Castelhano; José Sereno; Miguel Castelo-Branco; Luís De Almeida. "Blood-brain barrier dysfunction as a neuropathological feature in Machado-Joseph Disease: results from human and mouse samples". 2019.
    10.3389/CONF.FNCEL.2019.01.00022
  6. Sónia Duarte; Beatriz Estremores; Janete Cunha-Santos; Catarina Miranda; João Barata; Albert La Spada; Luis De Almeida. "Autophagy activation induced by let-7 microRNA overexpression counteracts disease phenotype in Machado-Joseph disease mouse models". 2019.
    10.3389/CONF.FNCEL.2019.01.00026
  7. Duarte, Sonia Patricia; Estremores, Beatriz; Cunha-Santos, Janete; Miranda, Catarina; Barata, Joao; La Spada, Albert; de Almeida, Luis Pereira. "Upregulation of let-7 microrna in mouse models of Machado-Joseph disease ameliorates neuropathology and motor phenotype". 2019.
  8. Matos, Carlos; Pena, Frederico; Conceicao, Andre; Lopes, Sara; Duarte, Sonia; Miranda, Catarina; de Almeida, Luis Pereira. "CRISPR interference-mediated silencing of mutant ATXN3 decreases motor impairments of an in vivo Machado-Joseph disease model". 2019.
  9. Nobre, Rui Jorge; Saraiva, Joana; Fusco, Clelia; Paixao, Susana; Santana, Magda; Miranda, Catarina; Petrella, Lorena; et al. "A miRNA-based gene therapy approach to knock-down mutant ATXN3: Alleviation of Machado-Joseph disease phenotype in two mouse models upon two routes of administration". 2019.
  10. Miranda, Catarina Oliveira; Marcelo, Adriana; Silva, Teresa Pereira; Barata, Joao; Vasconcelos-Ferreira, Ana; Pereira, Dina; Duarte, Sonia; et al. "Repeated transplantation of mesenchymal stromal cells in Machado-Joseph disease/Spinocerebellar ataxia type-3 mice can sustainably alleviate phenotypic symptoms and ameliorations can be monitored through magnetic resonance spectroscopy". 2019.
  11. Rui Nobre; Joana Saraiva; Susana Paixão; Cellia Fusco; Magda Santana; Catarina Miranda; Lorena Petrella; et al. "Non-invasive and allele-specific silencing therapy for Polyglutamine disorders: the case of Machado-Joseph disease/Spinocerebellar ataxia type 3". 2019.
    10.3389/CONF.FNCEL.2019.01.00007
  12. Matos, Carlos; Pena, Frederico; Conceicao, Andre; Lopes, Sara; Duarte, Sonia; Miranda, Catarina; de Almeida, Luis Pereira. "CRISPR-Cas9-Mediated Pre-Transcriptional Silencing of Mutant ATXN3 Decreases Motor Impairments of an In Vivo Machado-Joseph Disease Model". 2019.
  13. Duarte, S. P.; Estremores, B.; Cunha-Santos, J.; Miranda, C. O.; Barata, J.; La Spada, A. R.; de Almeida, L. P.. "Let-7 microRNA overexpression mediated by lentivirus alleviates neuropathology, balance and motor deficits in Machado-Joseph disease mouse models". 2019.
  14. Miranda, CO. "Miranda, C. O., Marcelo, A., Silva, T. P., Barata, J., Vasconcelos-Ferreira, A., Pereira, D., ... & Pereira de Almeida, L. (2018, December). Repeated mesenchymal stromal cells treatment sustainably alleviates Machado-Joseph disease/spinocerebellar ataxia type-3. In HUMAN GENE THERAPY (Vol. 29, No. 12, pp. A56-A56). 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA: MARY ANN LIEBERT, INC.". 2018.
  15. Miranda, CO. "Miranda, C. O., Nobre, R. J., Paiva, V. H., Castelhano, J., Petrella, L., Sereno, J., ... & Pereira de Almeida, L. (2018, December). Assessing cerebellar neurometabolic biomarkers by in vivo magnetic resonance spectroscopy in a transgenic mouse model of Machado-Joseph disease. In HUMAN GENE THERAPY (Vol. 29, No. 12, pp. A90-A90). 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA: MARY AN". 2018.
  16. Miranda, CO. "Nobre, Rui Jorge; Saraiva, Joana; Fusco, Clelia; Paixão, Susana; Santana, Magda M; Petrella, Lorena; Sereno, José; et al. "Non-Invasively Silencing and Monitoring Machado-Joseph Disease. Molecular Therapy". Abstract presented on the ASGCT 21st Annual Meeting 2018. Published". 2018.
Artigo em jornal
  1. Miranda, CO. "Programados para Falar: A arquitectura cerebral da linguageme o impacto da degeneração neuronal", Campeão das Províncias - local journal, 2025
  2. Ana Catarina Vinhais, Ana Cristina Ferreira, Carina Henriques, Carolina Silva, Catarina Miranda, Daniel Henriques, et al. ""A caminho de uma Terapia para a Doença de Machado-Joseph" - participation (scientific input) in the comic inside the article", Público, 2020
  3. Vinhas, A. C.; Ferreira A. C.; Henriques, C.; Silva, C.; Miranda, C; Henriques, D.; Oliveira, A. D.; et al. "Uma viagem rara", Público, 2020, https://www.publico.pt/2020/02/28/ciencia/fotogaleria/viagem-rara-400481.
Artigo em revista
  1. Henriques, Carina; Albuquerque, Patrícia; Rufino-Ramos, David; Lopes, Miguel M.; Leandro, Kevin; Miranda, Catarina O.; Almeida, Rita; et al. "Extracellular vesicles-associated AAVs for the treatment of Machado-Joseph disease". Molecular Therapy 34 1 (2026): 161-178. https://doi.org/10.1016/j.ymthe.2025.10.022.
    10.1016/j.ymthe.2025.10.022
  2. Cardoso, A.M.; Pereira, Maria Margarida; Pereira de Almeida, Luis ; Miranda, CO. Autor correspondente: Miranda, CO. "Submitted. Rewiring Glioma Cells: Direct Neuronal Reprogramming to Suppress Tumour Growth". submitted to Neuro-Oncology (2026):
    Submetido
  3. Barros, Inês; Lobo, Diana Duarte; Lopes, Sara M. ; Inês Morgado Martins; Henriques, Carina; Gomes, Célia; Nobre, Rui; Pereira de Almeida, Luis ; Miranda, CO. Autor correspondente: Miranda, CO. "Submitted. Mesenchymal Stromal Cell Therapeutic Potential to Restore Neurovascular Integrity in Machado-Joseph Disease". (2026):
    Submetido
  4. Pereira, P.; Patacas, Carlos; Barros, Inês; Luís, Ângelo; Pereira, Luísa; Miranda, CO. Autor correspondente: Miranda, CO. "Submitted. Global prevalence of PBDE-99 in pregnant women and newborns: a systematic review and meta-analysis (2001–2024).". (2026):
    Submetido
  5. Catarina Oliveira Miranda; Rhiannon Victoria McNeill; Donna Rose Addis; Noèlia Fernàndez-Castillo; Heather Macpherson; Mathilde Maughan; John J. Foxe; Dana L. Helmreich. "Editorial: Making Space for People With Disabilities: Part of the Diversity Matters Series". European Journal of Neuroscience (2025): https://doi.org/10.1111/ejn.70133.
    10.1111/ejn.70133
  6. Ambele, Melvin A.; Miranda, Catarina O.. "Editorial: Mesenchymal and induced-pluripotent stem cells as models to study biological processes". Frontiers in Genetics 15 (2024): http://dx.doi.org/10.3389/fgene.2024.1439306.
    10.3389/fgene.2024.1439306
  7. Pereira, Patricia; Neto, Ana S.; Rodrigues, Ana S.; Barros, Ines; Miranda, Catarina; Ramalho-Santos, Joao; Pereira de Almeida, Luis; et al. "In Vitro Evaluation of Biphasic Calcium Phosphate Scaffolds Derived from Cuttlefish Bone Coated with Poly(ester urea) for Bone Tissue Regeneration". Polymers (2023): https://publons.com/wos-op/publon/61175927/.
    10.3390/POLYM15102256
  8. Almeida, Sara F.F.; Fonseca, Alexandra; Sereno, José; Ferreira, Hugo R. S.; Lapo-Pais, Mariana; Martins-Marques, Tânia; Rodrigues, Teresa; et al. "Osteosarcoma-Derived Exosomes as Potential PET Imaging Nanocarriers for Lung Metastasis". Small 18 49 (2022): 2203999. http://dx.doi.org/10.1002/smll.202203999.
    10.1002/smll.202203999
  9. Miranda CO*, Nobre RJ*, Paiva VH, Duarte JV,Castelhano J, Petrella LI,Sereno J, Santana M, Afonso S, Januário C, Castelo. "Cerebellar morphometric and spectroscopic biomarkers for Machado-Joseph Disease.". Acta Neuropathologica Communications. Accepted for publication on February 9, 2022. (2022):
    10.1186/s40478-022-01329-4
  10. Neto, Ana S.; Pereira, Patrícia; Fonseca, Ana C.; Dias, Carla; Almeida, Mariana C.; Barros, Inês; Miranda, Catarina O.; et al. "Highly Porous Composite Scaffolds Endowed with Antibacterial Activity for Multifunctional Grafts in Bone Repair". Polymers 13 24 (2021): 4378. http://dx.doi.org/10.3390/polym13244378.
    10.3390/polym13244378
  11. Catarina Miranda. "Mesenchymal stem cells for lysosomal storage and polyglutamine disorders: Possible shared mechanisms". European Journal of Clinical Investigation (2021): https://doi.org/10.1111/eci.13707.
    10.1111/eci.13707
  12. Barros, Inês; Silva, António; de Almeida, Luís Pereira; Miranda, Catarina Oliveira. "Mesenchymal stromal cells to fight SARS-CoV-2: Taking advantage of a pleiotropic therapy". Cytokine & Growth Factor Reviews (2020): http://dx.doi.org/10.1016/j.cytogfr.2020.12.002.
    10.1016/j.cytogfr.2020.12.002
  13. Barros, Inês; Marcelo, Adriana; Silva, Teresa P.; Barata, João; Rufino-Ramos, David; Pereira de Almeida, Luís; Miranda, Catarina O.. "Mesenchymal Stromal Cells’ Therapy for Polyglutamine Disorders: Where Do We Stand and Where Should We Go?". Frontiers in Cellular Neuroscience 14 (2020): https://doi.org/10.3389/fncel.2020.584277.
    10.3389/fncel.2020.584277
  14. Duarte Lobo, Diana; Nobre, Rui Jorge; Oliveira Miranda, Catarina; Pereira, Dina; Castelhano, João; Sereno, José; Koeppen, Arnulf; Castelo-Branco, Miguel; Pereira de Almeida, Luís. "The blood-brain barrier is disrupted in Machado-Joseph disease/spinocerebellar ataxia type 3: evidence from transgenic mice and human post-mortem samples". Acta Neuropathologica Communications 8 1 (2020): http://dx.doi.org/10.1186/s40478-020-00955-0.
    10.1186/s40478-020-00955-0
  15. Oliveira Miranda, Catarina; Marcelo, Adriana; Silva, Teresa Pereira; Barata, João; Vasconcelos-Ferreira, Ana; Pereira, Dina; Nóbrega, Clévio; et al. "Repeated Mesenchymal Stromal Cell Treatment Sustainably Alleviates Machado-Joseph Disease". Molecular Therapy 26 9 (2018): 2131-2151. http://dx.doi.org/10.1016/j.ymthe.2018.07.007.
    10.1016/j.ymthe.2018.07.007
  16. Miranda, C. O.; Nobre, R. J.; Paiva, V. H.; Castelhano, J.; Petrella, L.; Sereno, J.; Castelo-Branco, M.; Pereira de Almeida, L.. "Assessing cerebellar neurometabolic biomarkers by in vivo magnetic resonance spectroscopy in a transgenic mouse model of Machado-Joseph disease". Human Gene Therapy (2018): https://publons.com/wos-op/publon/18798609/.
  17. Miranda, C. O.; Marcelo, A.; Silva, T. P.; Barata, J.; Vasconcelos-Ferreira, A.; Pereira, D.; Duarte, S.; et al. "Repeated mesenchymal stromal cells treatment sustainably alleviates Machado-Joseph disease/spinocerebellar ataxia type-3". Human Gene Therapy (2018): https://publons.com/wos-op/publon/18881710/.
  18. Teixeira, Carla Andreia; Miranda, Catarina Oliveira; Sousa, Vera Filipe; Santos, Telma Emanuela; Malheiro, Ana Rita; Solomon, Melani; Maegawa, Gustavo H.; Brites, Pedro; Sousa, Monica Mendes. "Early axonal loss accompanied by impaired endocytosis, abnormal axonal transport, and decreased microtubule stability occur in the model of Krabbe's disease". Neurobiology of Disease (2014): https://publons.com/publon/11055779/.
    10.1016/J.NBD2014.02.012
  19. Sá, Rosália; Miranda, Catarina; Carvalho, Filipa; Barros, Alberto; Sousa, Mário. "Expression of stem cell markers: OCT4, KIT, ITGA6, and ITGB1 in the male germinal epithelium". Systems Biology in Reproductive Medicine 59 5 (2013): 233-243. http://dx.doi.org/10.3109/19396368.2013.804964.
    10.3109/19396368.2013.804964
  20. Miranda CO; Teixeira CA; Sousa VF; Santos TE; Liz MA; Marques AM; Pinto-do-O P; Sousa MM. "Primary Bone Marrow Mesenchymal Stromal Cells Rescue the Axonal Phenotype of Twitcher Mice.". (2013): http://europepmc.org/abstract/med/23809254.
    10.3727/096368913X669752
  21. Miranda, C.O.; Brites, P.; Sousa, M.M.; Teixeira, C.A.. "Advances and pitfalls of cell therapy in metabolic leukodystrophies". Cell Transplantation 22 2 (2013): 189-204. http://www.scopus.com/inward/record.url?eid=2-s2.0-84874371497&partnerID=MN8TOARS.
    10.3727/096368912X656117
  22. Sá, R.; Miranda, C; Leite, C.; Malheiro, I.; Carvalho, F.; Silva, J.; Barros, A.; Sousa, M.; Miranda, C.. "Biomarkers Expression in Human Seminiferous Epithelium". Microscopy and Microanalysis 18 S5 (2012): 15-16. http://dx.doi.org/10.1017/s1431927612012731.
    10.1017/s1431927612012731
  23. Miranda, Catarina Oliveira; Teixeira, Carla Andreia; Liz, Márcia Almeida; Sousa, Vera Filipe; Franquinho, Filipa; Forte, Giancarlo; Di Nardo, Paolo; Pinto-Do-Ó, Perpétua; Sousa, Mónica Mendes. "Systemic Delivery of Bone Marrow-Derived Mesenchymal Stromal Cells Diminishes Neuropathology in a Mouse Model of Krabbe's Disease". STEM CELLS 29 11 (2011): 1738-1751. http://dx.doi.org/10.1002/stem.724.
    10.1002/stem.724
Capítulo de livro
  1. Mendonça, Liliana S.; Onofre, Isabel; Miranda, Catarina Oliveira; Perfeito, Rita; Nóbrega, Clévio; de Almeida, Luís Pereira. "Stem Cell-Based Therapies for Polyglutamine Diseases". In Advances in Experimental Medicine and Biology, 439-466. Springer International Publishing, 2018.
    10.1007/978-3-319-71779-1_21
Edição de número de revista
  1. Miranda, CO. "Sá, R., Miranda, C., Leite, C., Malheiro, I., Carvalho, F., Silva, J., ... & Sousa, M. (2012). Biomarkers Expression in Human Seminiferous Epithelium. Microscopy and Microanalysis, 18(S5), 15.". (2012):
Poster em conferência
  1. Miranda, CO. "Margarida Pereira, Inês Barros, Sara Lopes, Sónia Patrícia Duarte, Dina Pereira, Rita Perfeito, Rui Jorge Nobre, Luís Pereira de Almeida, Catarina Oliveira Miranda. “Transcription factor-mediatedglial reprogramming as a promising therapeutic approach for Machado-Joseph Disease”. 29th Annual Meeting of the portuguese Society of Genetic Disorders. 20-22 November 2025, Coimbra, Portugal.". 2025.
  2. RODRIGUES, M. T.; Paulo, Cristiana; Valdeira, A. S. C.; Santos Silva, Francisca; Marques, Bruno; Simões-Henriques, Carla; Gaspar, Laetitia S; et al. "Comparative Evaluation of mRNA Delivery Strategies in HEK293T Cells and Human Dermal Fibroblasts Using Linear, Self-Amplifying, and Circular RNA". Trabalho apresentado em 13th International mRNA Health Conference, 2025.
  3. RODRIGUES, M. T.; Paulo, Cristiana; Valdeira, A. S. C.; Santos Silva, Francisca; Marques, Bruno; Simões-Henriques, Carla; Gaspar, Laetitia S; et al. "Assessment of mRNA delivery approaches in HEK293T cells and Human Dermal Fibroblasts (HDF) with linear mRNA, self-amplifying mRNA (saRNA), and circular RNA (cRNA)". Trabalho apresentado em 29th Annual Meeting of the Portuguese Society of Human Genetics, 2025.
  4. Marques, Bruno; Simões-Henriques, Carla; RODRIGUES, M. T.; Paulo, Cristiana; Perdigão, PRL; Sónia P. Duarte; Miranda, CO; et al. "Optimizing Self-Amplifying RNA Production: A Comparative Study of IVT Methods, Rational Sequence Design, and Nucleotide Modifications". Trabalho apresentado em 13th International mRNA Health Conference, 2025.
  5. Simões-Henriques, Carla; Marques, Bruno; Paulo, Cristiana; Pereira, Dina; RODRIGUES, M. T.; Rita Perfeito; Sónia P. Duarte; et al. "Cost-Effective Optimization of Linear mRNA Synthesis: IVT Conditions, Sequence Engineering, and Nucleotide Modifications". Trabalho apresentado em 13th International mRNA Health Conference, 2025.
  6. Simões-Henriques, Carla; Marques, Bruno; Paulo, Cristiana; Pereira, Dina; RODRIGUES, M. T.; Rita Perfeito; Sónia P. Duarte; et al. "Cost-effective linear mRNA production through optimized in vitro transcription, rational sequence engineering, and chemically modified nucleotides". Trabalho apresentado em 29th Annual Meeting of the Portuguese Society of Human Genetics, 2025.
  7. Marques, Bruno; Simões-Henriques, Carla; RODRIGUES, M. T.; Paulo, Cristiana; Perdigão, PRL; Sónia P. Duarte; Miranda, CO; et al. "Optimized cost-effective production of self-amplifying RNA for RNA therapeutics: in vitro transcription conditions, sequence engineering, and chemically modified nucleotides". Trabalho apresentado em 29th Annual Meeting of the Portuguese Society of Human Genetics, 2025.
  8. Santos Silva, Francisca; Valdeira, A. S. C.; Paulo, Cristiana; RODRIGUES, M. T.; Gaspar, Laetitia S; Miranda, CO; Rita Perfeito; et al. "Advancing Circular RNA Therapeutics via Cost-Effective Production, Rational Sequencing Design, and Nucleotide Modifications". Trabalho apresentado em 13th International mRNA Health Conference, 2025.
  9. Valdeira, A. S. C.; Santos Silva, Francisca; Paulo, Cristiana; RODRIGUES, M. T.; Gaspar, Laetitia S; Miranda, CO; Rita Perfeito; et al. "Rational design and modified nucleotides enable cost-effective production of therapeutic circular RNA". Trabalho apresentado em 29th Annual Meeting of the Portuguese Society of Human Genetics, 2025.
  10. Miranda, CO. "Inês Barros, António Silva, Dina Pereira, Sónia P Duarte, Sara M Lopes, Rita Perfeito, Diogo Tomé, Ramiro Almeida, Rui J Nobre, Luís Pereira de Almeida, Catarina O Miranda*. Mesenchymal stromal cells tackle mitochondrial and autophagy deficits in SCA3, supporting neuronal recovery. ePoster presented in 35th Annual Symposium of the Network for European CNS Transplantation and Restoration, Coimbr". 2025.
  11. Miranda, CO. "M Pereira, I Barros, B Dias, V Santos, S Lopes, S Duarte, D Pereira, G Gabriel, R Perfeito, J Lourenço, R Faro, R Nobre, LP de Almeida and CO Miranda*.Evaluation of Ascl1 and Ngn2 for Direct Glial Reprogramming in Machado-Joseph Disease. 32nd ESGCT Annual Congress, Seville, Spain, October 2025.". 2025.
  12. Miranda, CO. "I Barros, A Silva, D Pereira, S Duarte, S Lopes, D Tome´, R Perfeito, No´brega C, R Faro, L Cortes, M Caldeira, T Catarino, R Almeida, R Nobre, LP de Almeida and CO Miranda*. Exploring the Mechanisms Behind MSC-Based Therapy for Spinocerebellar Ataxia Type-3. Paper presented in the XIX Meeting from the Portuguese Society for Neuroscience, Póvoa de Varzim, May 2025.". 2025.
  13. Miranda, CO. "I Barros I, A Silva, D Pereira, S Duarte, S Lopes, D Tomé, R Perfeito, Nóbrega C, R Faro, L Cortes, M Caldeira, T Catarino, R Almeida, R Nobre, LP de Almeida and CO Miranda*. Mechanistic insights into MSC Therapy for Machado-Joseph Disease: NGF as a central effector? International Congress for Ataxia Research (ICAR) 2024, London, November 2024.". 2024.
  14. De Luca, Pasqualino; Pedro Ricardo Lucas Perdigão; Gaspar, Laetitia S; Dina Maria da Silva Rodrigues Pereira; Bruno Filipe Pinheiro Marques; Sara Isabel Monteiro Lopes; Alexandra Melo; et al. "Maximizing mRNA vaccine production by optimizing in vitro transcription processes". Trabalho apresentado em 12th mRNA Health Conference, 2024.
  15. Gaspar, Laetitia S; Bruno Filipe Pinheiro Marques; De Luca, Pasqualino; Dina Maria da Silva Rodrigues Pereira; Pedro Ricardo Lucas Perdigão; Sara Isabel Monteiro Lopes; Rita Perfeito; et al. "Cost-Effective Optimization of Self-Amplifying mRNA Production: Comparative Analysis of Commercial Kits and In Vitro Transcription Conditions". Trabalho apresentado em 12th mRNA Health Conference, 2024.
  16. Dina Maria da Silva Rodrigues Pereira; Ana Sofia de Castro Valdeira; De Luca, Pasqualino; Gaspar, Laetitia S; Sara Isabel Monteiro Lopes; Pedro Ricardo Lucas Perdigão; Santos Silva, Francisca; et al. "Enhancing circular mRNA yield through in vitro transcription optimization". Trabalho apresentado em 12th mRNA Health Conference, 2024.
  17. Sónia P. Duarte; Rita Perfeito; Miranda, CO; RODRIGUES, M. T.; Paulo, Cristiana; Pereira, Dina; De Luca, Pasqualino; et al. "Functional assays to optimize transfection efficiency for linear, circular and self-amplifying mRNA". Trabalho apresentado em 12th mRNA Health Conference, 2024.
  18. Barros, Inês; Gonzaga, Daniela; Lobo, Diana Duarte; Lopes, Sara; Martins, Inês; Silva, António; Pereira de Almeida, Luís; Miranda, Catarina Oliveira. "Exploring Mesenchymal Stromal Cells' Potential to Restore Blood-Brain Barrier Integrity in Machado-Joseph Disease". Trabalho apresentado em Innovative Therapies 4th CiBB Retreat 2024, 2024.
  19. Barros, Inês; Silva, António; Lobo, Diana Duarte; Gonzaga, Daniela; Mele, Miranda; Pereira, Dina; Faro, Rosario; et al. "Mesenchymal Stromal Cell potential to restore autophagy and mitochondria health in Machado-Joseph disease". Trabalho apresentado em 31th Annual Meeting of the European Society of Gene & Cell Therapy, 2024.
  20. Barros, Inês; Gonzaga, Daniela; Lobo, Diana Duarte; Lopes, Sara; Martins, Inês; Pereira de Almeida, L; Miranda, Catarina. Autor correspondente: Miranda, Catarina. "The Guardians of Balance: Mesenchymal Stem Cells as a Promising Strategy to Restore Blood-brain Barrier Integrity in Spinocerebellar Ataxia Type 3.". Trabalho apresentado em 30th Annual Meeting of the European Society of Gene & Cell Therapy, 2023.
  21. Miranda, CO. "Pinto AS, Veri´ssimo S.N, Silva A, Fernandes B, Santos, de Luca, Santana M, Barros I, Cortes L, dos Santos I, Perdiga~o P, Pinho, Coelho, de Almeida, Pereira P, Paiva, Miranda CO.“Can we contribute to a ”Less Plastic” Brain?” 1st Green Labs Portugal Symposium: Promoting Sustainability in Research, Coimbra, Portugal, 22nd of September of 2023". 2023.
  22. Miranda, CO. "Mendes C; Marques C; Mota S; Afonso M; Alves A; Amaral S; Candeias E; Cardoso M; Cortes L; Cruz T; Da Silva J; Duarte SP; Fernandes T; Ferreira H; Ferreira M; Girão H; Gonçalves M; Grilo LF; Lavoura N; Léger H; Lourenço CF; Manadas B; Martins B; Marques MP; Mele M; Miranda C; et al., “Collection Points” – Reuse and Recycling.” 1st Green Labs Portugal Symposium: Promoting Sustainability in Res.". 2023.
  23. Miranda, CO. "Santos B, Afonso M, Alves A, Amaral S, Amorim R, Candeias E, Cardoso M, Cortes L, Cruz T, Duarte S, Faria S, Fernandes T, Ferreira AC, Ferreira M, Girão H, Gonçalves M, Lavoura N, Léger H, Manadas B, Marques C, Marques CI, Mele M, Mendes C, Miranda C, et al., “One Path For Sustainable Research”. 1st Green Labs Portugal Symposium: Promoting Sustainability in Research, Coimbra, Portugal". 2023.
  24. Miranda, CO. "Alarico S, Afonso M, Alves A, Amaral S, Amorim R, Candeias E, Cardoso M, Cortes L, Cruz T, Duarte S, Faria S, Fernandes T, Ferreira AC, Ferreira M, Girão H, Gonçalves M, Lavoura N, Léger H, Manadas B, Marques C, Marques CI, Mele M, Mendes C, Miranda C, et al. “One Path For Sustainable Research”. Envisioning the Research Centres of the Future, EU-LIFE Community Meeting 2023, Lisbon, Portugal". 2023.
  25. Barros, Inês; Gonzaga, Daniela; Lobo, Diana Duarte; Martins, Inês; Duarte, Sónia; Nobre, Rui Jorge; Pereira de Almeida, Luis ; Miranda, Catarina. Autor correspondente: Miranda, Catarina. "Mesenchymal Stromal Cell Therapeutic Potential to Restore Blood-Brain Barrier Integrity in Machado-Joseph Disease". Trabalho apresentado em FENS Regional Meeting 2023 (FRM), 2023.
  26. Silva A†, Barros I†, Lobo D, Gonzaga D, Pereira D, Cortes L, de Almeida LP and Miranda CO.. "Mesenchymal Stromal Cells Uptake Mutant Ataxin-3 and Alleviate Late Autophagy and Mitophagy Impairments in Spinocerebellar Ataxia Type-3 (In Vitro and In Vivo) Models. Congress of the Portuguese Society of Movement Disorders, Luso, Portugal, March 17-18, 2023". 2023.
  27. Da Silva, Antonio; Barros, Ines; Lobo, Diana; Gonzaga, Daniela; de Almeida, Luis Pereira; Miranda, Catarina Oliveira. "MESENCHYMAL STROMAL CELLS THERAPY RESCUES MITOPHAGY IN MACHADO-JOSEPH DISEASE MODELS". 2022.
  28. Barros, Inês; Gonzaga, Daniela; Lobo, Diana Duarte; Nobre, Rui Jorge; Martins, Inês; Silva, António; Duarte, Sónia; Pereira de Almeida, L; Miranda, Catarina Oliveira. "Altered Tight Junction-Associated Proteins Subcellular Localization in Machado-Joseph Disease/Spinocerebellar Ataxia Type 3.". Trabalho apresentado em 26ª Annual Meeting of Sociedade Portuguesa de Genética Humana (SPGH), 2022.
  29. 4. Silva A†, Barros I†, Lobo D, Gonzaga D, de Almeida LP* and Miranda CO*. "Mesenchymal Stromal Cells therapy rescues mitophagy in Machado-Joseph Disease models. 26ª Annual Meeting of Sociedade Portuguesa de Genética Humana (SPGH), in Coimbra, Portugal, November 17-19, 2022". Trabalho apresentado em Annual Meeting of Sociedade Portuguesa de Genética Humana (SPGH), 2022.
  30. 3. Barros I†, Gonzaga D†, Lobo D, Nobre RJ, Martins I, Silva A, Duarte S, de Almeida LP* and Miranda CO*. "Altered Tight Junction-Associated Proteins Subcellular Localization in Machado-Joseph Disease/Spinocerebellar Ataxia Type 3. 26ª Annual Meeting of Sociedade Portuguesa de Genética Humana (SPGH), in Coimbra, Portugal, November 17-19, 2022". Trabalho apresentado em Annual Meeting of Sociedade Portuguesa de Genética Humana (SPGH), 2022.
  31. Barros, Inês; Gonzaga, Daniela; Lobo, Diana Duarte; Martins, Inês; Silva, António; Duarte, Sónia; Nobre, Rui Jorge; Pereira de Almeida, Luis ; Miranda, Catarina Oliveira. Autor correspondente: Miranda, Catarina Oliveira. "Unravelling Mesenchymal Stromal Cells Potential for Alleviation of Blood-Brain Barrier Disruption in Machado-Joseph Disease". Trabalho apresentado em 12th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies, 2022.
  32. Barros MI, Gonzaga D, Lobo D, Martins I, Silva A, Duarte SP, Nobre RJ, de Almeida LP, Miranda CO.. "Barros MI, Gonzaga D, Lobo D, Martins I, Silva A, Duarte SP, Nobre RJ, de Almeida LP, Miranda CO. Unravelling Mesenchymal Stromal Cells Potential for Alleviation Of Blood-Brain Barrier Disruption In Machado-Joseph Disease. 12th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies (SPCE-TC), Braga, Portugal, March 10 – 11, 2022.". Trabalho apresentado em 12th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies (SPCE-TC), 2022.
  33. Barros, Inês; Silva, António; Martins, Inês; Duarte, Sónia; Nobre, Rui Jorge; Simões, Ana Teresa; Pereira de Almeida, Luis ; Oliveira Miranda, Catarina. "Therapeutic effects of Mesenchymal Stromal Cells Secretome in Machado-Joseph Disease Models.". Trabalho apresentado em XVII Meeting of the Portuguese Society for Neuroscience, 2021.
  34. So´nia Patri´cia Duarte, Beatriz Estremores, Janete Cunha-Santos, Catarina Oliveira Miranda, Joa~o Barata, Diana Santos,. "Sónia Patrícia Duarte, Beatriz Estremores, Janete Cunha-Santos, Catarina Oliveira Miranda, Joa~o Barata, Diana Santos, Maciej Figiel, Albert La Spada, Luis Pereira de Almeida. "MicroRNA profiling in Spinocerebellar ataxia type-3: On the development of a miRNA-based therapy", NAF's biennial Ataxia Investigators Meeting (AIM 2020)---Postponed to May 24-27, 2021.". Trabalho apresentado em NAF's biennial Ataxia Investigators Meeting, 2021.
  35. Miranda, CO. "Barros M.I., da Silva A, Martins I, Duarte S, Nobre RJ, Simões AT, de Almeida LP and Miranda CO (2021). Therapeutic effects of Mesenchymal Stromal Cells Secretome in Machado-Joseph Disease Models. XVII Meeting of the Portuguese Society for Neuroscience in Coimbra, 1-3th de December 2021". 2021.
  36. Sara F.F. Almeida, Nuno Lima, Rui C. Oliveira, Tânia Martins-Marques, Teresa Ribeiro-Rodrigues, Henrique Girao, Catarina. "Preconditioning mice with osteosarcoma cells-derived secretome promote tumour cells engraftment and lung metastasis development. Lisbon Portugal, 02-04 March 2020". Trabalho apresentado em EACR-AACR-ASPIC Basic and Translational Research Conference – Tumor Microenvironment, 2020.
  37. Sara F.F. Almeida, Nuno Lima, Tânia Martins-Marques, Teresa Ribeiro-Rodrigues, Rui C. Oliveira, Catarina O.Miranda et al. "Secretome derived from osteosarcoma (OS) cells promote tumour cell colonization and lung metastasis formation in pre-treated mice. CIIB Meeting in Coimbra, Portugal, December 19-20, 2019.". Trabalho apresentado em Center for Innovative Biomedicine and Biotechnology (CIIB) Meeting, 2019.
  38. Almeida, Sara F.F.; Lima, Nuno; Oliveira, Rui; Martins-Marques, Tânia; Miranda, Catarina Oliveira; Pereira de Almeida, Luis Fernando Morgado; Amílcar, Falcão; Abrunhosa, Antero; Gomes, Célia. "Secretome derived from osteosarcoma (OS) cells promote tumour cell colonization and lung metastasis formation in pre-treated mice". Trabalho apresentado em CIBB Meeting 2019 - Universidade de Coimbra, 2019.
  39. Barros, Inês; Martins, Inês; Duarte, Sónia; Nobre, Rui Jorge; Simões, Ana Teresa; Gomes, Célia; Oliveira Miranda, Catarina; Pereira de Almeida, Luis. "Assessing the putative role of mesenchymal stromal cells' effectors in Machado-Joseph disease". Trabalho apresentado em 1st Annual meeting in Pharmaceutical Sciences in Coimbra, Portugal, 2019.
  40. Barros MI, Martins I, Duarte S, Nobre RJ, Simões AT, Miranda CO and de Almeida LP.. "“Assessing the putative role of mesenchymal stromal cells’ effectors in Machado-Joseph disease.” Annual Meeting in Pharmaceutical Sciences, Coimbra, Portugal. November 15, 2019.". Trabalho apresentado em Annual Meeting in Pharmaceutical Sciences, 2019.
  41. Sara Almeida, Nuno Lima, Tânia Martins-Marques, Henrique Girão, Catarina Miranda, Luis Pereira de Almeida et al.. "Osteosarcoma-released bioactive factors facilitate lung metastasis by regulating cell adhesion. 2nd joint EACR-MRS Conference - Seed and Soil: Mechanisms of Metastasis Berlin, Germany, 07 - 09 October 2019.". Trabalho apresentado em 2nd joint EACR-MRS Conference - Seed and Soil: Mechanisms of Metastasis, 2019.
  42. Lobo DD*, Nobre RJ*, Miranda CO*, Pereira D, Castelhano J, Sereno J, Castelo-Branco M, de Almeida LP.. "“Blood-brain barrier dysfunction in Spinocerebellar ataxia type 3 (Machado-Joseph disease): results from mouse and human brain tissues.” Society for Neuroscience meeting. Chicago, USA, 19-23, October. *authors have contributed equally for this work". Trabalho apresentado em Society for Neuroscience meeting, 2019.
  43. Almeida, Sara F.F.; Lima, Nuno; Martins-Marques, Tânia; Girao, Henrique; Miranda, Catarina Oliveira; Pereira de Almeida, Luis Fernando Morgado; Amílcar, Falcão; Abrunhosa, Antero; Gomes, Célia. "Osteosarcoma-released bioactive factors facilitate lung metastasis by regulating cell adhesion". Trabalho apresentado em Seed and Soil: mechanisms of metastasis (2nd joint EACR-MRS conference), 2019.
  44. Miranda, Catarina Oliveira; Marcelo, Adriana; Silva, Teresa P.; Barata, João; Vasconcelos-Ferreira, Ana; Pereira, Dina; Duarte, Sónia; et al. "Sustainable phenotypic ameliorations in Machado-Joseph Disease/Spinocerebelar ataxia type-3 can be reached by repeated systemic administrations of mesenchymal stromal cells – and can be monitored through proton Magnetic Resonance Spectroscopy biomarkers.". Trabalho apresentado em XVI Meeting of the Portuguese Society for Neuroscience (SPN2019), 2019.
  45. Duarte SP, Estremores B, Cunha-Santos J, Miranda CO, Barata J, La Spada AR, de Almeida LP.. "“Upregulation of let-7 microrna in mouse models of Machado-Joseph disease ameliorates neuropathology and motor phenotype.” 53rd Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI) in Coimbra, Portugal. 22-24 May 2019". Trabalho apresentado em 53rd Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI), 2019.
  46. Miranda CO, Marcelo A, Silva T, Barata J, Vasconcelos-Ferreira A, Pereira D, Duarte S, Nóbrega C, Sereno J, et al.. "“Sustainable phenotypic ameliorations in MJD/SCA3 can be reached by repeated systemic administrations of MSC – and can be moand can be monitored through H-MRS. SPN2019 in Lisbon, Portugal.". Trabalho apresentado em XVI Meeting of the Portuguese Society for Neuroscience (SPN2019), 2019.
  47. Nobre RJ, Saraiva J, Fusco C, Paixao S, Santana M, Miranda C, Petrella L, Sereno J, Castelhano J, Castelo-Branco M et al. "“Non-invasive and allelle-specific silencing therapy for polyglutamine disorders: the case of Machado-Joseph disease/spinocerebellar ataxia type 3”. SPN2019 in Lisbon, Portugal.". Trabalho apresentado em XVI Meeting of the Portuguese Society for Neuroscience (SPN2019), 2019.
  48. Lobo D*, Nobre RJ*, Miranda CO*, Pereira D, Castelhano J, Sereno J, Castelo-Branco M, de Almeida LP.. "“Blood-brain barrier dysfunction as a neuropathological feature in Machado-Joseph disese: results from human and MJD mouse samples”. XVI Meeting of the Portuguese Society for Neuroscience (SPN2019) in Lisbon, Portugal. 30 May - 1 June 2019. *authors have contributed equally for this work". Trabalho apresentado em XVI Meeting of the Portuguese Society for Neuroscience (SPN2019), 2019.
  49. Matos CA, Conceição A, Pena F, Lopes S, Duarte S, Miranda C, de Almeida LP.. "“Transcriptional repression of mutant human ATNX3 using CRISPR interference mitigates the pathological phenotype of an in vivo Machado-Joseph disease model.” XVI Meeting of the Portuguese Society for Neuroscience (SPN2019) in Lisbon, Portugal. 30 May - 1 June 2019". Trabalho apresentado em XVI Meeting of the Portuguese Society for Neuroscience (SPN2019), 2019.
  50. Catarina Oliveira Miranda; Adriana Marcelo; Teresa P. Silva; João Barata; Inês Barros; Vasconcelos-Ferreira, Ana; Dina Pereira; et al. "Sustainable phenotypic ameliorations in Machado-Joseph Disease/ Spinocerebellar ataxia type-3 can be reached by repeated systemic administrations of mesenchymal stromal cells- and can be monitored through proton magnetic resonance spectroscopy biomarkers.". Trabalho apresentado em XVI Meeting of the Portuguese Society for Neuroscience SPN2019, Lisbon, 2019.
  51. Catarina Oliveira Miranda; Adriana Marcelo; Teresa P. Silva; João Barata; Vasconcelos-Ferreira, Ana; Dina Pereira; Sónia Duarte; et al. "Repeated treatment with mesenchymal stromal cells sustainably alleviates Machado-Joseph Disease and Its Efficacy Can Be Monitored With Neurospectroscopic Biomarkers". Trabalho apresentado em 1st international symposium Secretome With]Out[ Borders, Braga, Portugal, 2018.
  52. Albuquerque, Patricia Rosado; Santana, Magda M; Nobre, Rui Jorge; Miranda, Catarina Oliveira; Lopes, Sara Monteiro; Ribeiro-Rodrigues, Teresa; Girao, Henrique; Gomes, Célia; Pereira de Almeida, Luis Fernando Morgado. "Non-invasive delivery with hybrid extracelular vesicles for therapy of Machado Joseph-disease". Trabalho apresentado em International Society for Extracellular Vesicles Annual Meeting, 2018.
  53. Miranda CO, Machado A, Silva T, Barata J, Vasconcelos-Ferreira A, Pereira D, Duarte S, Nóbrega C, Sereno J, et al.. "“Repeated treatment with MSC sustainably alleviates MJD and Its Efficacy Can Be Monitored With Neurospectroscopic Biomarkers”. 1st int. symposium Secretome With]Out[ Borders, Braga Portugal,". Trabalho apresentado em 1st international symposium Secretome With]Out[ Borders, 2018.
  54. Miranda CO, Machado A, Silva T, Barata J, Vasconcelos-Ferreira A, Pereira D, Duarte S, Nóbrega C, Sereno J, et al.. "“Repeated mesenchymal stromal cells treatment sustainably alleviates Machado-Joseph Disease/Spinocerebellar ataxia type-3.” 26th Congress of the ESGCT, Lausanne, Switzerland.". Trabalho apresentado em 26th Congress of the European Society of Gene and Cell Therapy (ESGCT), 2018.
  55. Miranda CO, Nobre RJ, Paiva VH, Castelhano J, Peretrella LI, Sereno J, Castelo-Branco M and de Almeida LP.. "“Assessing in vivo cerebellar neurometabolic biomarkers of Machado-Joseph Disease/Spinocerebellar ataxia type-3 through correlative studies of in vivo Magnetic Resonance Spectroscopy with motor behavior in a transgenic mouse model”. 26th Congress of the ESGCT, Lausanne, Switzerland". Trabalho apresentado em 26th Congress of the European Society of Gene and Cell Therapy (ESGCT), 2018.
  56. Duarte SP, Estremores B, Cunha-Santos J, Miranda CO, Barata J, La Spada AR, de Almeida LP.. "“Let-7 microRNA overexpression mediated by lentivirus alleviates neuropathology, balance and motor deficits in Machado-joseph disease mouse models”, 26th Congress of the European Society of Gene and Cell Therapy (ESGCT), Lausanne, Switzerland.". Trabalho apresentado em 26th Congress of the European Society of Gene and Cell Therapy (ESGCT), 2018.
    10.23919/eusipco.2018.8553329
  57. Duarte S, Miranda CO, Cunha-Santos J, Barata J, Estremores B, La Spada AR, de Almeida LP.. "“Let-7 activates autophagy and alleviates motor and neuropathological deficits in pre- and post-symptomatic Machado-Joseph disease mouse models.” International Ataxia Research Conference, Pisa, Italy.". Trabalho apresentado em International Ataxia Research Conference, 2017.
  58. Miranda CO, Machado A, Silva T, Barata J, Pereira D, Vasconcelos-Ferreira A, Nóbrega C, Peretrella L, Sereno J, et al.. "“Repeated treatment with mesenchymal stromal cells sustainably alleviates MJD/SCA-3 through neuroprotection of GABAergic neurons”. 10th International Meeting of the SPCE-TC, Covilhã, Portugal.". Trabalho apresentado em 10th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies (SPCE-TC)., 2017.
    10.1109/issre.2016.53
  59. Duarte S, Miranda CO, Cunha-Santos J, Barata J, La Spada AR, de Almeida LP.. "“Autophagy activation mediated by let-7 alleviates motor and neuropathological deficits in pre- and post-symptomatic Machado-Joseph disease mouse models.” XV Meeting of the Portuguese Society for Neuroscience, Braga, Portugal.". Trabalho apresentado em XV Meeting of the Portuguese Society for Neuroscience, 2017.
  60. Miranda CO, Machado A, Silva T, Barata J, Nóbrega C, Duarte S, Nobre R, Sereno J, Paiva V, Castelhano J, et al.. ""Repeated systemic injection of mesenchymal stem cells sustainably alleviates motor impairments and mitigates neuropathology in Machado-Joseph disease.” XV Meeting of the Portuguese Society for Neurosciences, Braga, Portugal.". Trabalho apresentado em XV Meeting of the Portuguese Society for Neurosciences, 2017.
  61. Miranda, Catarina Oliveira; Machado, Adriana; Silva, T.; Barata, João; Nobrega, Clévio; Duarte, Sónia; Nobre, Rui Jorge; et al. "Repeated systemic injection of mesenchymal stem cells sustainably alleviates motor impairments and mitigates neuropathology in Machado-Joseph disease". Trabalho apresentado em XV Meeting of the Portuguese Society for Neurosciences, 2017.
  62. Petrella, Li; Sereno, José V; Miranda, Catarina; Nobre, Rui Jorge; Castelhano, João; Pereira de Almeida, Luis Fernando Morgado; Castelo-Branco, Miguel. "Evaluation of brain structures volumes on a transgenic mouse model of Machado-Joseph disease". Trabalho apresentado em VII Annual Meeting of IBILI, 2015.
  63. Petrella LI, Sereno JV, Miranda C, Nobre R, Castelhano J, Pereira de Almeida L and Castelo-Branco M.. "“Evaluation of brain structures volumes on a transgenic mouse model of Machado-Joseph disease.” VII Annual Meeting of IBILI, Coimbra, Portugal.". Trabalho apresentado em VII Annual Meeting of IBILI, 2015.
  64. Miranda CO, Marcelo A, Silva T, Nóbrega C, Sereno J, Castelhano J, Castelo-Branco M, and de Almeida LP.. "“Transplantation of mesenchymal stem cells alleviates motor impairments and neuropathology in mouse models of Machado-Joseph disease.” 9th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies (SPCE-TC), Oeiras, Portugal.". Trabalho apresentado em 9th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies (SPCE-TC), 2015.
  65. Miranda CO, Silva T, Nóbrega C and de Almeida LP.. "“Transplantation of mesenchymal stem cells alleviates motor impairments and neuropathology of a mouse model of Machado-Joseph disease”. International Society for Stem Cell Research (ISSCR) 2015 annual meeting, Stockholm, Sweden.". Trabalho apresentado em International Society for Stem Cell Research (ISSCR) annual meeting, 2015.
  66. Magda M Santana; Nóbrega, Clévio David Rodrigues ; Nobre, Rui Jorge; Miranda, Catarina; Sousa-Ferreira, Ligia; Simões, Ana Teresa; Duarte, Sónia; et al. "Gene therapy approaches to investigate pathogenesis and disease modifying strategies for neurodegenerative diseases". Trabalho apresentado em Showcasing Portuguese Pharma Science:Advances in Discovery, Development and Manufacturing. Hovione and MIT Portugal Pharma Science Symposium, 2014.
  67. Silva T, Miranda CO, Nóbrega C and de Almeida LP.. "“Cerebellar transplantation of mesenchymal stem cells alleviates motor impairments and neuropathology in a transgenic mouse model of Machado-Joseph disease”. XII CNC meeting, Coimbra, Portugal.". Trabalho apresentado em XII CNC meeting, 2014.
  68. Teixeira CA, Miranda CO, Sousa VF, Santos TE, Brites P, Sousa MM.. "“Impaired Endocytosis, Abnormal Vesicular Transport, and Decreased Microtubule Stability Mediate Signaling Defects and Early Loss in Krabbe’s Disease.” Program No. 340.20/Y8. Neuroscience Meting Planner. San Diego, CA: Society for Neuroscience, 2013. Online.". Trabalho apresentado em Society for Neuroscience meeting, 2013.
  69. Santos TE, Miranda CO, Sousa MM, Teixeira CA.. "“Myelin-independent Axonal Pathology in Krabbe’s Disease is Characterized by Lipid Raft Clustering and Impaired Axonal Transport.” 3rd I3S Scientific Retreat IBMC/INEB/IPATIMUP Together in Science, Póvoa de Varzim, Portugal.". Trabalho apresentado em 3rd I3S Scientific Retreat IBMC/INEB/IPATIMUP Together in Science, 2012.
  70. Miranda CO, Teixeira CA, Liz MA, Sousa V, Franquinho F, Forte G, di Nardo P, Pinto-do-Ó P and Sousa MM.. "“Systemic Delivery of Bone Marrow-Derived Mesenchymal Stromal Cells Promotes Axonal Survival in a Mouse Model of Krabbe’s Disease.” 2nd I3S Scientific Retreat IBMC/INEB/IPATIMUP Together in Science, Póvoa de Varzim, Portugal.". Trabalho apresentado em 2nd I3S Scientific Retreat IBMC/INEB/IPATIMUP Together in Science, 2011.
    10.5151/cobecic2019-ftsp4
  71. Miranda CO, Teixeira CA, Liz MA, Sousa V, Franquinho F, Forte G, di Nardo P, Pinto-do-Ó P and Sousa MM.. "“Systemic Delivery of Bone Marrow-Derived Mesenchymal Stromal Cells Promotes Axonal Survival in a Mouse Model of Krabbe’s Disease.” 6th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies (SPCE-TC), Cantanhede, Portugal.". Trabalho apresentado em 6th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies (SPCE-TC), 2011.
  72. Miranda C, Teixeira CA, Liz MA, Sousa V, Forte G, di Nardo P, Pinto-do-Ó P and Sousa MM.. "“Mesenchymal stromal cells promote axonal outgrowth.” 1st I3S Scientific Retreat – IBMC/INEB/IPATIMUP Together in Science, Póvoa de Varzim, Portugal.". Trabalho apresentado em 1st I3S Scientific Retreat – IBMC/INEB/IPATIMUP Together in Science, 2010.
  73. Miranda C, Teixeira CA, Liz MA, Franquinho F, Forte G, di Nardo P, Pinto-do-Ó P and Sousa MM.. "“Mesenchymal stromal cells promote axonal outgrowth.” Gordon Research Conference (GRC) on Myelin, Ventura Beach, CA, U.S.A.". Trabalho apresentado em Gordon Research Conference (GRC) on Myelin, 2010.
  74. Miranda C, Liz MA, Teixeira CA, Franquinho F, Forte G, di Nardo P, Pinto-do-Ó P and Sousa MM.. "“Mesenchymal stromal cells immortalized with mTERT promote axonal outgrowth.” 11ª Reunião da Sociedade Portuguesa de Neurociências, Braga, Portugal.". Trabalho apresentado em 11ª Reunião da Sociedade Portuguesa de Neurociências, 2009.
  75. Miranda C, Liz MA, Teixeira CA, Franquinho F, Forte G, di Nardo P, Pinto-do-Ó P and Sousa MM.. "“Mesenchymal stromal cells immortalized with mTERT promote axonal outgrowth.” 2nd IBMC Scientific Retreat. Póvoa de Varzim, Portugal.". Trabalho apresentado em 2nd IBMC Scientific Retreat, 2009.
  76. Miranda C, Liz MA, Teixeira CA, Franquinho F, Forte G, di Nardo P, Pinto-do-Ó P and Sousa MM.. "“Mesenchymal stromal cells immortalized with mTERT promote axonal outgrowth.” Program No. 640.5. 2009 Neuroscience Meting Planner. Chicago, IL: Society for Neuroscience, 2009. Online.". Trabalho apresentado em Society for Neuroscience meeting, 2009.
  77. Miranda C, Franquinho F, Gonçalves AF, and Sousa MM.. "“Intravenous and Local Delivery of Mesenchymal Stem Cells in Demyelinated Mouse Models Improves Recovery and Remyelination.” 1st IBMC Scientific Retreat. Ofir, Portugal.". Trabalho apresentado em 1st IBMC Scientific Retreat, 2008.
  78. Craveiro LM, Miranda C, Franquinho F, Gonçalves AF, and Sousa MM.. "“Mesenchymal Stem Cells Improve Functional Recovery and Remyelination in Demyelinated Mice by a Paracrine Mechanism. “Program No. 572.12. 2008 Neuroscience Meting Planner. Washington, DC: Society for Neuroscience, 2008. Online.". Trabalho apresentado em Society for Neuroscience meeting, 2008.
  79. Miranda C, Gonçalves AF, and Sousa MM.. ""Intravenous Delivery of Mesenchymal Stromal Cells in Demyelinated Mouse Models Improves Functional Recovery.” 10th Meeting of the Portuguese Society for Neurosciences, Ofir, Portugal.". Trabalho apresentado em 10th Meeting of the Portuguese Society for Neurosciences, 2007.
    10.1109/enbeng.2011.6026049
  80. Miranda C, Gonçalves AF, and Sousa MM.. "“Improved functional recovery of demyelination mouse models following i.v. delivery of marrow mesenchymal stromal cells.” Program No. 800.15. 2007 Neuroscience Meting Planner. San Diego, CA: Society for Neuroscience, 2007. Online.". Trabalho apresentado em Society for Neuroscience meeting, 2007.
  81. Gonçalves AF, Miranda C, Pinto-do-Ó P, Relvas JB and Sousa MM.. "“Evaluation of the Therapeutic Potential of the Intravenous Delivery of Neural Stem Cells and Mesenchymal Stromal Cells in Demyelinated Mouse Models.” 1st European Leukodystrophy Association-ELA Research Foundation Congress, Paris, France.". Trabalho apresentado em 1st European Leukodystrophy Association-ELA Research Foundation Congress, 2006.
  82. Miranda C, Alves C, Pinho MJ, Fernandes S, Carvalho F, Silva J, Sousa M, Barros A.. "“Expression of progenitor adult stem cells markers within the male germ epithelium.” 9th Meeting of the Human Genetics Portuguese Society, Cascais, Portugal.". Trabalho apresentado em 9th Meeting of the Human Genetics Portuguese Society, 2005.
  83. Miranda C, Henriques P, Almeida Santos T.. "“The Effects of Cryopreservation on Sperm Motility and Vitality.” EAA Internacional Symposium – Genetics of Male Infertility: from Research to Clinic, Florence, Italy.". Trabalho apresentado em EAA Internacional Symposium – Genetics of Male Infertility: from Research to Clinic, 2003.
Pré-impressão
  1. Barros, Inês; Gonzaga, Daniela; Lobo, Diana; Lopes, Sara; Martins, Inês; Silva, António; Silva, Carina Henriques; et al. "Mesenchymal Stromal Cell Therapeutic Potential to Restore Neurovascular Integrity in Machado-Joseph Disease". 2026. https://doi.org/10.64898/2026.01.31.703043.
    10.64898/2026.01.31.703043
Recurso online
  1. Miranda, CO. Selfie Science - video spread throught social networks explaining myresearch/activity in the lab for non-scientists. The publication of this video was done to celebrate the International Ataxias Day.. 2019. https://video.fopo1-1.fna.fbcdn.
Resumo em conferência
  1. Miranda, CO. "I Barros, A Silva, D Lobo, D Gonzaga, M Mele, D Pereira, R Faro, L Cortes, LP de Almeida, CO Miranda. Mesenchymal Stromal Cell potential to restore autophagy and mitochondria health in Machado-Joseph disease. Paper presented in 31st Annual Meeting of the European Society of Gene & Cell Therapy – ESGCT 2024, Roma, 2024. HUMAN GENE THERAPY 36(3-4), pp.E268-E268, 36:e129–e557 (February 2025). P027". 2025.
  2. Catarina Oliveira Miranda; Perfeito, Rita; Sónia P. Duarte; Paulo, Cristiana; RODRIGUES, M. T.; Gaspar, Laetitia S; Dina Maria da Silva Rodrigues Pereira; et al. "Comparative analysis of transfection kits for linear, self-amplifying, and circular RNA". Trabalho apresentado em 31st Annual Meeting of the European Society of Gene & Cell Therapy – ESGCT 2024, Roma, 2024.
    Publicado
  3. Gaspar, Laetitia S; Bruno Filipe Pinheiro Marques; Dina Maria da Silva Rodrigues Pereira; De Luca, Pasqualino; Pedro Ricardo Lucas Perdigão; Sara Isabel Monteiro Lopes; Rita Perfeito; et al. "Maximizing Yield and Functionality in saRNA Production: A Comparative Study of Commercial Kits and In Vitro Transcription Conditions". Trabalho apresentado em 31st Annual Meeting of the European Society of Gene & Cell Therapy – ESGCT 2024, Roma, 2024.
    Publicado
  4. De Luca, Pasqualino; Sara Isabel Monteiro Lopes; Dina Maria da Silva Rodrigues Pereira; Gaspar, Laetitia S; Bruno Filipe Pinheiro Marques; Pedro Ricardo Lucas Perdigão; Alexandra de Almeida e Melo; et al. "Optimizing in vitro transcription methods for enhanced mRNA-based therapeutics". Trabalho apresentado em 31st Annual Meeting of the European Society of Gene & Cell Therapy – ESGCT 2024, Roma, 2024.
    Publicado
  5. Dina Maria da Silva Rodrigues Pereira; Ana Sofia de Castro Valdeira; Francisca Santos Silva; Gaspar, Laetitia S; De Luca, Pasqualino; Pedro Ricardo Lucas Perdigão; Sara Isabel Monteiro Lopes; et al. "A comparative analysis of commercial kits for enhanced circular mRNA production: yield, profile, and in vitro assessment". Trabalho apresentado em 31st Annual Meeting of the European Society of Gene & Cell Therapy – ESGCT 2024, Roma, 2024.
    Publicado
  6. Miranda, CO. "Silva A†, Barros I†, Lobo D, Gonzaga D, de Almeida LP* and Miranda CO*. Mesenchymal Stromal Cells therapy rescues mitophagy in Machado-Joseph Disease models. Paper presented at the 26ª Annual Meeting of Sociedade Portuguesa de Genética Humana (SPGH). MEDICINE, Volume 102, Issue 13, Publisehd on March 31, 2023 † Equal contribution". 2023.
  7. Albuquerque, Patrícia; Santana, Magda M; Nobre, Rui Jorge; Miranda, Catarina Oliveira; Lopes, Sara; Ribeiro-Rodrigues, TM; Girao, Henrique; Gomes, Célia; Pereira de Almeida, Luis Fernando Morgado. "Non-invasive brain delivery with hybrid extracellular vesicles (EVs) for therapy of Machado-Joseph disease (MJD), Journal of Extracellular Vesicles". 2018.
    Publicado
  8. Miranda, CO. "25. Miranda, C., Liz, M., Teixeira, C., Franquinho, F., Forte, G., & Di-Nardo, P. Pinto-do-O P and Mendes-Sousa M (2009). Mesenchymal stromal cells immortalized with MTERT promote axonal outgrowth. In Front. Neurosci. Conference Abstract: 11th Meeting of the Portuguese Society for Neuroscience. doi (Vol. 10). doi: 10.3389/conf.neuro.01.2009.11.056.". 2009.
Tese / Dissertação
  1. "Reprogramming astrocytes into neurons to treat Spinocerebellar Ataxia Type-3 Proof-of-concept studies". Mestrado, 2024. https://hdl.handle.net/10316/117902.
  2. "Glioma-To-Neurons Reprogramming as a Technology for Escaping Glioma Proliferation". Mestrado, 2024. https://hdl.handle.net/10316/117964.
  3. "Unraveling Neurovascular Dysfunctions in Machado-Joseph Disease: Mesenchymal Stromal Cells as a Promising Therapy". Doutoramento, 2024. https://hdl.handle.net/10316/116133.
  4. "Mesenchymal Stromal Cells for Machado-Joseph Disease - Implications in mitochondria and quality control pathways.". Mestrado, 2022. https://hdl.handle.net/10316/104713.
  5. "Evaluating the Potential of Mesenchymal Stromal Cells in the Alleviation of Blood-Brain Barrier Impairments in Machado-Joseph Disease.". Mestrado, 2021. https://hdl.handle.net/10316/99144.
  6. "Assessing the putative role of mesenchymal stromal cells’ effectors in Machado-Joseph disease". Mestrado, 2019. https://hdl.handle.net/10316/86421.
  7. "Unravelling the players of mesenchymal stromal cells’ neuroprotective effect in Machado-Joseph disease". Mestrado, 2017. https://hdl.handle.net/10316/82985.
  8. "Cerebrovascular and Blood-Brain Barrier Impairments in Machado-Joseph Disease". Mestrado, 2017. http://hdl.handle.net/10362/25829.
  9. "Repeated systemic transplantation of mesenchymal stromal cells: a therapeutic strategy for Machado-Joseph disease?". Licenciatura, 2016. https://hdl.handle.net/10316/41012.
  10. "Multipotent mesenchymal stromal cells for Machado-Joseph disease therapy". Mestrado, 2014. https://hdl.handle.net/10316/30598.
  11. Miranda, Catarina. "Bone Marrow-Derived Mesenchymal Stromal Cell Transplantation: An Add-on Option for Krabbe’s Disease.". Doutoramento, 2012.
  12. Miranda, Catarina. "Expression of Progenitor Adult Cell Markers in the Male Germinal Epithelium.". Mestrado, 2005.
  13. Miranda, Catarina. "Human Reproduction Techniques and Cryopreservation of Male Gametes.". Licenciatura, 2003.

Artística / Interpretação

Conto de ficção
  1. Miranda, CO; SF Gallery. 2023. "Short fiction organized by me and created by Sandra Fernades (SF Gallery) showing our indifference to plastic contamination in nature, along with a brief explanation of the Project, its objectives, how and with what purpose it was created, this last filmed by the Explratório Ciência Viva-UC team.".
Exposição artística
  1. Photography exhibition "Brain Flows for the Flawless". Presented at the CIBB Meeting 2025. In this exhibition, photographer Carlos Gomes captures pivotal moments from the dance performance Brain on the Path to Perfection, which translates the challenges of living with Machado–Joseph Disease (MJD) into a powerful and evocative choreography.. 2025.
  2. The Brain Flows for the Flawless Photography exhibition was presented at the FENS Regional Meeting 2023. In this exhibition, the photographer Carlos Gomes captured key moments of the dance performance "Brain on the Path of Perfection, which translated the difficulties of living with MJD into an impactful choreography.. 2023.
  3. Art Exhibition to call the attention for the maleficits of plastics was created. This Art exhibition was composed by: 1) a plastic piece made by Bordalo II, 2) hands-on activities for children with messages calling the attention for the urgent need to stop consuming, recycling, and find alternatives to the use of plastics. Performed at Exploratório-UC. May-October 2023. 2023.
Interpretação artística
  1. 2022. Dance performance "The Brain on the Path to Perfection”. Included in the Less Rare innitiatve, it was organized by me and choreographed and performed by the Rita Grade Dance School (EDRG), where I was included. The performance aimed to translate the challenges of living with MJD while highlighting researchers' efforts to discover effective therapies for this rare codition..

Outros

Outra produção
  1. Several hand-on activities were developed, namely: a puzzle, crosswords and “Quantos-queres?”, highlighting important concepts of direct reprogramming of astrocytes into neurons, in a very simplistic point of view, that were used in NEI 2024, and later on in school visits.. 2024. Miranda, CO.
  2. Round Table - “Conversa Não Programa”, Exploratório – Centro Ciência Viva de Coimbra. Participation of Vitor Paiva (PhD, Centro de Ciências do Mar e do Ambiente, UC), Filipa Bessa (PhD, Centro de Ciências do Mar e do Ambiente, UC), Patrícia Pereira (PhD, Centro de Engenharia Mecânica, Materiais e Processos, UC) and COM (Centro de Neurociências e Biologia Celular da UC). Thematic issues discussed: the huge impact that plastics have on nature, living beings and humans; the increasing rates of plastic products consumption, as well as the great increasing amounts of plastic waste delivered everyday to the oceans and the impact it generates; fake policies aiming to demonstrate reduced plastic fabrication/consuption, especially in certain packages.. 2023. Miranda, CO; Paiva, Vitor H.; Bessa, Filipa.
  3. Development of Educative Puzzles and a Quiz under the thematic of the project “Less PLastic Brain”. These materials have been used in school visits, scientific events (e.g., Circular Economy 2023, 1st Green Labs Portugal Symposium: Promoting Sustainability) and were also in the Science and Art Exhibition at Exploratório Ciência Viva-UC. May-October 2023.. Educative materials were created, namely, puzzles made from photography showing plastic rubbish contaminating the beautiful nature, magnetic puzzles with informative sentences regarding this. with people acting if that was perfectly normal, a Quiz game containing questions and curiosities regarding the use of plastics, and a short video showing our indifference to plastic contamination in nature,. 2023. Miranda, CO; Barros, Inês.
  4. Informative leaflet - "Doença de Machado-Joseph: O que é? Como viver com ela?". Informative leaflet to distribute among MJD patients and families or caretakers, in the “Doença de Machado-Joseph: do Laboratório par a Sociedade” within Rare Diseases Day, 2020.. 2020. Catarina Miranda, Inês Barros, Luís Pereira de Almeida, Magda Santana, Marta Quatorze, Patrick Silva, Sara Amaral..
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2026/03/25 Oral Presentation by Invitation. "Entre fibras e plástico: o impacto invisível das nossas escolhas." Catarina Miranda, VII EcoView, 25 de Março de 2026, Escola de Hotelaria e Turismo de Coimbra, Coimbra, Portugal.
2026/03/13 Oral Presentation by Invitation. "Mesenchymal Stem Cells As a Therapeutic Tool for Machado-Joseph Disease: Pre-clinical and Clinical Evidences". Catarina Miranda, Reunião Anual da Sociedade Portuguesa das Doenças do Movimento (SPDMov), 12-13 Março, Fátima, Portugal. Convite para ser oradora na Sessão Conjunta da SPDMov e da Sociedade Portuguesa de Neurociências (SPN).
2025/11/18 Selected oral talk. M Pereira, I Barros, B Dias, V Santos, S Lopes, S Duarte, D Pereira, G Gabriel, R Perfeito, J. Lourenço; R Faro, R Nobre, LP de Almeida and CO Miranda. “Transcription Factor-Mediated Glial Reprogramming as a Therapeutic Strategy for Machado-Joseph Disease.” 5th Workshop on Neuroengineering: AI tools in Neuroscience”, led at I3S, Universidade do Porto (2025), Instituto de Investigação e Inovação em Saúde (I3S), Universidade do Porto (2025).
2025/10/22 Oral presentation. Margarida Pereira*, Inês Barros, Sara Lopes, Sónia Duarte, Dina Pereira, Rita Perfeito, Rui Nobre, Luís Pereira de Almeida and Catarina Oliveira Miranda. Ascl1 and Ngn2 as Key Factors in Direct Glial Reprogramming in Spinocerebellar Ataxia 3. 35th Annual Symposium of the Network for European CNS Transplantation and Restoration (NECTAR 2025), Coimbra, October 2025.
2025/10/22 Oral presentation. Inês Barros, António Silva, Dina Pereira, Sónia P Duarte, Sara M Lopes, Rita Perfeito, Diogo Tomé, Ramiro Almeida, Rui J Nobre, Luís Pereira de Almeida, Catarina O Miranda*. Mesenchymal stromal cells tackle mitochondrial and autophagy deficits in SCA3, supporting neuronal recovery. ePoster. 35th Annual Symposium of the Network for European CNS Transplantation and Restoration (NECTAR 2025), Coimbra, October 2025.
2024/09/18 Oral presentation. I Barros*, D Gonzaga, D Lobo, S Lopes, I Martins, A Silva, LP de Almeida and CO Miranda. Exploring Mesenchymal Stromal Cells' Potential to Restore Blood-Brain Barrier Integrity in Machado-Joseph Disease. Flash Poster Presentation, Innovative Therapies 4th CiBB Retreat 2024, September 2024.
2024/04 Oral Presentation by invitation. Miranda C. “Mesenchymal stromal cells: what can we learn from them in Machado-Joseph disease or Spinocerebellar ataxia type-3 context?” DCV.talks – Departamento das Ciências e da Vida (DCV) in Coimbra, Portugal, April 17, 2024.
2024/03 Seminar from the “Semana da Ciência UC 2024”, named “Biologia marinha e neurociências - Uma relação inusitada” given at the Secondary School Adolfo Portela, Águeda at March 2024.
2024/02 Oral presentation. Barros I, Gonzaga D, Lobo D, Lopes S, Martins I, Silva A, Gomes C, Duarte S, Nobre R, de Almeida LP and Miranda CO. “Mesenchymal Stromal Cell Therapeutic Potential to Restore Neurovascular Integrity in Spinocerebellar Ataxia type 3.” 54ª Reunião da Sociedade Portuguesa de Farmacologia (SPF) in Lisbon, Portugal, February 7-9, 2024.
2023/06 Oral presentation by invitation. Miranda C*, Pereira P*, Paiva V*. "Less Plastic Brain: Impacto dos Aditivos Plásticos no Desenvolvimento Cerebral Humano e Possíveis Alternativas". Coimbra Circular 23 in Exploratório-UC, Ciência Viva de Coimbra, Coimbra, Portugal, Junho 14, 2023. *Co-presentors Coimbra Circular 23
(Coimbra, Portugal)
2023/05 Oral presentation. Silva A†, Barros I†, Lobo D, Gonzaga D, Cortes L, de Almeida LP and Miranda CO. “Induction of mutant atxin-3 uptake, and late autophagy and mitophagy improvements may contribute to reduction of mutant ataxin-3 levels in Spinocerebellar Ataxia Type-3 models.” FENS Regional Meeting 2023, Algarve, Portugal, 3-5 May 2023.
2023/03 Oral presentation by invitation. Silva A*, Barros I*, Lobo D, Gonzaga D, Pereira D, Cortes L, de Almeida LP and Miranda CO. "Let's make a puzzle: unravelling how Mesenchymal Stromal Cells decrease mutant ataxin-3 levels and promote ameliorations in Machado-Joseph Disease?" DCV.talks - Departamento das Ciências e da Vida (DCV) in Coimbra, Portugal, March 29, 2023. *Equal contribution DCV.talks - Departamento das Ciências e da Vida (DCV)
2023/03 Oral presentation. Barros MI, Gonzaga D, Lobo D, Nobre RJ, Martins MI, Silva A, Duarte SP, de Almeida LP, and Miranda CO. “Understanding the Mechanisms of Blood-Brain Barrier Dysregulation in Machado-Joseph Disease”. Congress of the Portuguese Society of Movement Disorders, Luso, Portugal, March 17-18, 2023 † Equal contribution
2023/03 Seminar from the “Semana da Ciência UC 2023”, named “Biologia marinha e neurociências - Uma relação inusitada” given at the Secondary School Adolfo Portela, Águeda at March 2023.
2023/02 Oral presentation. Silva A†, Barros I†, Lobo D, Gonzaga D, de Almeida LP* and Miranda CO*. Mesenchymal Stromal Cells Alleviate Autophagy and Mitochondria Dynamics Alterations In Machado-Joseph Disease Models. 53ª Reunião da Sociedade Portuguesa de Farmacologia (SPF) in Porto, Portugal, February 1-3, 2023 † Equal contribution
2022/12 Oral presentation by invitation. Silva A*, Barros I*, Lobo D, Gonzaga D, Pereira D, Cortes L, de Almeida LP and Miranda CO. "Mesenchymal Stem Cells for Brain Disorders: the Particular case of Machado-Joseph Disease." Seminar given inside the Gene and Cell Therapy Curricular Unit from the Biomedical Sciences Graduation, Algarve University ¿ Online Event December 5th, 2022.
2022/02 Oral presentation. Barros MI, Gonzaga D, Lobo D, Martins MI, Silva A, Duarte SP, Nobre RJ, de Almeida LP, Miranda CO. Assessing the Potential of Mesenchymal Stromal Cells for Alleviation of Blood-Brain Barrier Dysfunction in Machado-Joseph Disease. XXXVIII Reunião de Farmacologia Clínica e XIX Reunião de Toxicologia, Porto, Portugal, Fevereiro de 2022. XXXVIII Reunião de Farmacologia Clínica e XIX Reunião de Toxicologia
2021/06 Oral presentation by invitation. Miranda CO, Lobo D, Nobre RJ, Gonzaga D, Barros MI, Martins MI, Castelhano J, Pereira D, Sereno J, Koeppen A, Castelo-Branco M, de Almeida LP. “Blood-brain barrier (BBB) disruption is a shared feature for several neurodegenerative diseases.” 55TH ANNUAL SCIENTIFIC MEETING OF the European Society of Clinical Investigation (ESCI) – Online Event June 9th – 11th, 2021.
2021/06 Oral presentation. 6. Miranda CO, Lobo D, Nobre RJ, Gonzaga D, Barros MI, Martins MI, Castelhano J, Pereira D, Sereno J, Koeppen A, Castelo-Branco M, de Almeida LP. Blood-brain barrier (BBB) disruption is a shared feature for several neurodegenerative diseases. 55TH ANNUAL SCIENTIFIC MEETING OF the European Society of Clinical Investigation (ESCI) – Online Event June 9th – 11th, 2021. 55TH ANNUAL SCIENTIFIC MEETING OF the European Society of Clinical Investigation (ESCI)
2021/03 Oral presentation by invitation. Miranda CO. "In Vitro Systems to Access the Paracrine Effects of Mesenchymal Stromal Cells and Their Application to Neurodegenerative Disorders". VI Semana da Bioengenharia, Instituto Superior Técnico de Lisboa, Onine event. March 8-12, 2021.
2020/12 Oral presentation by invitation. Miranda CO, Machado A, Silva T, Nóbrega C, Barata J, Sereno J, Paiva V, Castelhano J, Castelo-Branco M and de Almeida LP. “Mesenchymal Stem Cells for Brain Disorders: the Particular case of Machado-Joseph Disease.” Seminar given inside the Gene and Cell Therapy Curricular Unit from the Biomedical Sciences Graduation, Algarve University – Online Event December 18th, 2020.
2020/10 Oral presentation by invitation. Miranda CO, Lobo D, Nobre RJ, Gonzaga D, Barros MI, Martins MI, Castelhano J, Pereira D, Sereno J, Koeppen A, Castelo-Branco M, de Almeida LP. "Blood-brain barrier disruption in Machado-Joseph disease/spinocerebellar ataxia type 3: clinical and therapeutic implications." CIBB Neuroscience and Disease thematic Line, Joint Data-Clubs, Online Event. October 14, 2020.
2020/03 Oral presentation by invitation. Miranda CO, Barros I, Barata J, Marcelo A, Silva TP, Vasconcelos-Ferreira A, Pereira D, Nóbrega C, Duarte S, Alves J, Sereno J, Peretrella LI, Castelhano J, Paiva VH, Martins I, Simões AT, Rodrigues-Santos P, Alves V, Nunes-Correia I, Nobre RJ, Gomes C, Castelo-Branco M and de Almeida LP. "MSC Success in Promoting Ameliorations in Machado-Joseph Disease." Departamento das Ciências e da Vida (DCV) - DCV.talks, in Coimbra, Portugal, March 4, 2020. Department of Life Science Seminar Series
(Coimbra, Portugal)
2020 Oral presentation - Osteosarcoma cells-derived secretome induce structural lung damage favorable for metastasis formation. XLIX Reunião da Sociedade Portuguesa de Farmacologia, XXXVII Reunião de Farmacologia Clínica e XVIII Reunião de Toxicologia, Porto, Portugal 6-8 Fevereiro de 2020 XLIX Reunião da Sociedade Portuguesa de Farmacologia, XXXVII Reunião de Farmacologia Clínica e XVIII Reunião de Toxicologia
(Porto, Portugal)
2019 Oral presentation by invitation. Miranda CO, Barros I, Barata J, Marcelo A, Silva TP, Vasconcelos-Ferreira A, Pereira D, Nóbrega C, Duarte S, Alves J, Sereno J, Peretrella LI, Castelhano J, Paiva VH, Martins I, Simões AT, Rodrigues-Santos P, Alves V, Nunes-Correia I, Nobre RJ, Gomes C, Castelo-Branco M and de Almeida LP (2019). ¿MSC Success in Promoting Ameliorations in Machado-Joseph Disease - Where do We Stand and Where We Should Go?¿ Center for Innovative Biomedicine and Biotechnology (CIIB) Meeting in Coimbra, Portugal, December 19-20, 2019. Center for Innovative Biomedicine and Biotechnology (CIIB) Meeting in Coimbra, Portugal.
Center for Innovative Biomedicine and Biotechnology (CIIB)
2019 Oral presentation by invitation. Miranda CO, Marcelo A, Silva TP, Barata J, Vasconcelos-Ferreira A, Pereira D, Duarte S, Barros I, Nóbrega C, Sereno J, Peretrella L, Paiva V, Castelhano J, Nobre R, Gomes C, Castelo-Branco M and de Almeida LP. “Repeated transplantation of mesenchymal stromal cells in Machado-Joseph Disease/Spinocerebelar ataxia type-3 can sustainably alleviate phenotypic symptoms and ameliorations can be monitored through magnetic resonance spectroscopy”. 53rd Annual Scientific Meeting of the ESCI in Coimbra. 53rd Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI) in Coimbra, Portugal.
European Society for Clinical Investigation (ESCI)
2019 Oral Presentation - Allele-specific and Non-invasive AAV-based silencing of mutant ataxin-3 alleviates neuropathology and motor deficits in Spinocerebellar ataxia type 3. International Ataxia Research Conference (IARC), Washington, USA.
International Ataxia Research Conference (IARC)
2019 Oral Presentation - Spectroscopic Biomarkers as a Way of Monitoring MSC Success in Promoting Neuropathological and Phenotypic Ameliorations in Machado-Joseph Disease Models. 11th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies (SPCE-TC) in Lisbon, Portugal.
Portuguese Society for Stem Cells and Cell Therapies (SPCE-TC)
2019 Oral Presentation - A miRNA-based gene therapy approach to knock-down mutant ATXN3: alleviation of Machado-Joseph disease phenotype in two mouse models upon two routes of administration. 53rd Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI) in Coimbra, Portugal.
European Society for Clinical Investigation (ESCI)
2019 Oral Presentation - CRISPR interference-mediated silencing of mutant ATXN3 decreases motor impairments of an in vivo Machado-Joseph disease model. 53rd Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI) in Coimbra, Portugal.
European Society for Clinical Investigation (ESCI)
2019 Oral Presentation - Autophagy activation induced by let-7 microRNA overexpression counteracts disease phenotype in Machado-Joseph Disease Mouse Models. XVI Meeting of the Portuguese Society for Neuroscience (SPN2019) in Lisbon, Portugal.
Portuguese Society for Neuroscience (SPN)
2019 Oral Presentation - Disruption of blood-brain barrier in Machado-Joseph Disease. XLIX Reunião Anual da Sociedade Portuguesa de Farmacologia, Faculdade de Farmácia, Universidade do Porto, Portugal.
Sociedade Portuguesa de Farmacologia (SPF)
2019 Oral presentation - Lobo, Diana Duarte*; Rui Jorge Nobre*; Catarina Oliveira Miranda*; Pereira, Dina; Castelhano, Joâo; Sereno, José Vitor Oliveira; Castelo-Branco, Miguel; Pereira de Almeida, Luis. Blood-brain barrier dysfunction as a neuropathological feature in Machado-Joseph Disease. 1st Annual Meeting in Pharmaceutical Sciences. (2019) Portugal, Coimbra, 15 Nov. *Equal contribution 1st Annual Meeting in Pharmaceutical Sciences
(Coimbra, Portugal)
2018 Oral Presentation by Invitation. Miranda C. Conference on the topic “Mesenchymal stromal cells for the treatment of spinocerebellar ataxias: can they make the difference?”, on the CNC.IBILI Seminars from Center for Neuroscience and Cell Biology & Institute for Biomedical Imaging and Life Sciences at Center for Neuroscience and Cell Biology, Coimbra, Portugal. 2018 CNC.IBILI Seminars from Center for Neuroscience and Cell Biology & Institute for Biomedical Imaging and Life Sciences at Center for Neuroscience and Cell Biology
Center for Neuroscience and Cell Biology
2018 Oral Presentation - Non-invasive brain delivery of hybrid extracellular vesicles for therapy of Machado-Joseph Disease (MJD). Annual Meeting ISEV2018, Barcelona, Spain.
International Society of Extracellular Vesicles
2018 Oral Presentation - Repeated mesenchymal stromal cells treatment sustainably alleviates Machado-Joseph Disease/Spinocerebelar ataxia type-3 AND therapeutic success can be monitored by 1H-MRS. SPDMov 2018 Meeting – “Genética nas Doenças do Movimento”, Curia, Portugal.
Sociedade Portuguesa de Doenças do Movimento (SPDMov)
2018 Oral Presentation - Let-7 microRNA-based therapy alleviates neuropathology, imbalance and motor incoordination in Machado-Joseph disease. SPDMov 2018 Meeting – “Genética nas Doenças do Movimento”, Curia, Portugal.
Sociedade Portuguesa de Doenças do Movimento (SPDMov)
2018 Oral Presentation - Hybrid vesicles: a promising therapeutic approach for MJD. 1st Meeting on Vesicular Biology, Coimbra, Portugal.
2018 Oral Presentation - Exosomes: tiny vesicles with great potential for MJD treatment. XII Spanish-Portuguese Conference on Controlled Drug Delivery - Tailoring drug delivery systems to the patients’ needs, Coimbra, Portugal.
Spanish Portuguese Local Chapter
2018 Oral Presentation - Repeated mesenchymal stromal cells treatment sustainably alleviates Machado-Joseph disease. XLVIII Reunião Anual da Sociedade de Farmacologia, Lisboa, Portugal.
Sociedade Portuguesa de Farmacologia (SPF)
2018 Oral Presentation - Let-7 mitigates neuropathology and motor deficits in mouse models of Machado-Joseph disease. XLVIII Reunião Anual da Sociedade de Farmacologia, Lisboa, Portugal.
Sociedade Portuguesa de Farmacologia (SPF)
2018 Oral Presentation - Cerebrovascular and blood-brain barrier impairments in Machado-Joseph Disease. XLVIII Reunião Anual da Sociedade de Farmacologia, Lisboa, Portugal.
Sociedade Portuguesa de Farmacologia (SPF)
2017 Oral Presentation - Let-7 activates autophagy and alleviates motor and neuropathological deficits in pre- and post-symptomatic Machado-Joseph disease mouse models. International Ataxia Research Conference (IARC), Pisa, Italy.
Ataxia UK together with GoFar (Italian organisation) and FARA (American organisation)
2017 Oral Presentation - Sustainable alleviation of motor impairments and neuropathology upon repeated intravenous transplantation of mesenchymal stromal cells in Machado-Joseph disease. XLVII Reunião Anual da Sociedade de Farmacologia, Coimbra, Portugal.
Sociedade Portuguesa de Farmacologia (SPF)
2017 Poster Presentation - Repeated treatment with mesenchymal stromal cells sustainably alleviates Machado-Joseph Disease/Spinocerebellar ataxia type-3 through neuroprotection of GABAergic neurons. 10th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies (SPCE-TC), Covilhã, Portugal.
Portuguese Society for Stem Cells and Cell Therapies (SPCE-TC)
2016 Oral Presentation - Repeated intravenous transplantation of mesenchymal stromal cells sustainable alleviates motor impairments and mitigates neuropathology in Machado-Joseph disease. Brain Without Borders Meeting, Coimbra, Portugal.
Portuguese Society for Stem Cells and Cell Therapies (SPCE-TC)
2014 Oral Presentation - Mesenchymal stem cells for Machado-Joseph disease therapy. XVIII Congress of the Portuguese Biochemical Society, Coimbra, Portugal.
Portuguese Biochemical Society
2014 Oral Presentation - Cerebellar transplantation of mesenchymal stromal cells alleviates motor impairments and neuropathology of a transgenic mouse model of Machado-Joseph disease. Term Stem Conference, Porto, Portugal.
Term Stem
2011 Oral Presentation - Systemic Delivery of Bone Marrow-Derived Mesenchymal Stromal Cells Diminishes Neuropathology in a Mouse Model of Krabbe's Disease. VIII International Symposium of Sociedade Portuguesa de Doenças Metabólicas, Porto, Portugal.
Sociedade Portuguesa de Doenças Metabólicas (SPDM)
2010 Oral Presentation - Immortalized bone marrow-derived mesenchymal stromal cells promote axonal survival in a mouse model of Krabbe´s disease. Adult Progenitor Cell Standardization Meeting, Rome, Italy.
Disputationes
2008 Oral Presentation by Invitation - Miranda C. Conference on the topic “Terapia Celular em Doenças da Mielina”, on the Seminar “Células Estaminais – o Presente o Futuro”, Instituto Politécnico de Castelo Branco - IPCB, Castelo Branco, Portugal, 2008. Seminar "Células Estaminais - o Presente o Futuro" (2008), Instituto Politécnico de Castelo Branco - IPCB, Castelo Branco, Portugal.
Instituto Politécnico de Castelo Branco
2008 Oral Presentation - Intravenous and Local Delivery of Mesenchymal Stem Cells in Demyelinated Mouse Models Improves Functional Recovery and Remyelination. 3rd International Meeting of the Portuguese Society for Stem Cells and Cell Therapies (SPCE-TC), Faro, Portugal.
Portuguese Society for Stem Cells and Cell Therapies (SPCE-TC)
2007 Oral Presentation - Intravenous Delivery of Mesenchymal Stromal Cells in Demyelinated Mouse Models Improves Functional Recovery. V Simpósio da Sociedade Portuguesa de Doenças Metabólicas, Porto, Portugal.
Sociedade Portuguesa de Doenças Metabólicas (SPDM)
2007 Oral Presentation - Intravenous Delivery of Neural and Mesenchymal Stromal Cells in Demyelinated Mouse Models Improves Functional Recovery. 2nd International Meeting of the Portuguese Society for Stem Cells and Cellular Therapy (SPCE-TC), Coimbra, Portugal.
Portuguese Society for Stem Cells and Cell Therapies (SPCE-TC)
2005 Oral Presentation - Expression of stem and progenitor cell markers in the human male germ line. XL th Annual Meeting of the Portuguese Society for Electron Microscopy and Cell Biology, Lisbon, Portugal.
Portuguese Society for Electron Microscopy and Cell Biology
2003 Oral Presentation - The Effects of Cryopreservation on Sperm Motility and Vitality. 1st Internacional Congress of Cryobiology (Cryobiomol), Coimbra, Portugal.
The Society for Low Temperatures and the Society for Cryobiology

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2025/09/15 - Atual Master Thesis - Pedro Sotelo. Master student on Ecology from the Department of Life Scieneces. Thesis theme: “(Less)PlasticBrain – Bio replacing plasticizers – Impact in the human brain development.” Finalization on: September 2026.
Orientador
2025/09/15 - Atual Master Thesis - Eva Povkhanych. Mater student in Cellular and Molecular Biology of Faculty for Sciences and Technology of University of Coimbra. Thesis theme: “A Combined Neuronal Reprogramming and Allele-Specific Silencing Strategy for the Treatment of Spinocerebellar Ataxia Type 3”. Finalization: September 2026.
Orientador
2025/04/01 - Atual Undergraduate student training (Eva PovKanych). Supervision of a 4-week Laboratory rotation. Master student in Cellular and Molecular Biology of University of Coimbra, under the theme “direct reprogramming of astrocytes into neurons”. April 2025.
Orientador
2023/09 - Atual Master thesis - Vanessa Silva Santos. Master in Biochemistry of Faculty for Sciences and Technology of University of Coimbra. Thesis theme: "Reprogramming of astrocytes into healthy neurons to treat Machado-Joseph Disease/Spinocerebellar Ataxia Type-3". Completed on September 2024.
Orientador
2019/12/01 - Atual PhD Thesis - Maria Inês Barros. PhD student of the PhD Programme in Experimental Biology and Biomedicine PDBED of University of Coimbra, awarded with an FCT fellowship with the reference SFRH/BD/148877/2019. Thesis theme: "From mesenchymal stromal cells to its secretome: Clarifying the mechanism of alleviation of Machado-Joseph disease". Completed on July 2024 (Co-Supervisor: Luís Pereira de Almeida, PhD).
Orientador
PhD Programme in Experimental Biology and Biomedicine PDBED, Portugal
2023/09 - 2024/09 Master thesis - Brenda Fernandes Dias. Master in Cellular and Molecular Biology of Faculty for Sciences and Technology of University of Coimbra. Thesis theme: "Glia-To-Neurons Reprogramming as a Technology for Escaping Glioma Proliferation". Completed on September 2024.
Orientador
2023/05 - 2023/07 Undergraduate student training (André Pinto). Sstudent from Bachelor’s degree in Biotechnology of the Politécnico Institute of Coimbra. Thesis theme: “Optimization of a pipeline for human induced pluripotent stem cells- derived neurons characterization after exposure to fossil-based and bio- based plastic additives.” May – July 2023. (Co-Supervision with So´nia Luzia Claro de Pinho, PhD).
Orientador
2021/06 - 2022/09 Master Thesis - António Dinis da Silva. Master in Cellular and Molecular Biology of Faculty for Sciences and Technology of University of Coimbra. Thesis theme: "Unscrambling the therapeutic mechanisms of Mesenchymal Stromal Cells and their secretome in Machado-Joseph Disease models". Junho 2021 - Setembro 2022.
Orientador
2020/10/01 - 2021/12 Master Thesis - Daniela Gonzaga. Master in Pharmaceutical Biotechnology of Faculty of Pharmacy of University of Coimbra. Thesis theme: " Evaluating the Potential of Mesenchymal Stromal Cells in the Alleviation of Blood-Brain Barrier Impairments in Machado-Joseph Disease". October 2020 - December 2021.
Orientador
2017/09 - 2019/02 Master Thesis - Maria Inês Barros. Master student in Pharmaceutical Biotechnology of Faculty of Pharmacy of University of Coimbra. Thesis theme: "Assessing the putative role of mesenchymal stromal cells' effectors in Machado-Joseph disease". September 2017 - February 2019. (Co-Supervisor: Luís Pereira de Almeida, PhD).
Orientador
2016/09 - 2017/09 Master Thesis - Diana Filipa Duarte Lobo. Master student in Molecular Genetics and Biomedicine of Faculty for Sciences and Technology of New University of Lisbon. Thesis theme: "Cerebrovascular and Blood-Brain Barrier Impairments in Machado-Joseph Disease". September 2016 - September 2017. (Co-supervision with Rui Jorge Nobre, PhD)
Coorientador
2016/09 - 2017/07 Master Thesis - João Carlos Versos Varanda Barata. Master student in Cellular and Molecular Biology of Faculty for Sciences and Technology of University of Coimbra. Thesis theme: "Unravelling the players of mesenchymal stromal cells neuroprotective effect in Machado-Joseph disease". September 2016 - September 2017. (Co-supervisor: Emília Duarte, PhD)
Orientador
Faculty for Sciences and Technology from University of Coimbra (FCTUC), University of Coimbra (UC), Portugal, Portugal
2015/09 - 2016/06 Master Thesis - Adriana Isabel do Vale Marcelo. Master student in Biomedical Investigation of Faculty of Medicine of University of Coimbra. Thesis theme: "Repeated systemic transplantation of mesenchymal stromal cells: a therapeutic strategy for Machado-Joseph disease?". September 2015 - June 2016. (Co-Supervision with Henrique Girão, PhD).
Coorientador
Faculty of Medicine of University of Coimbra, Portugal
2013/09 - 2014/09 Master Thesis -Teresa Maria Pereira da Silva. Master student in Pharmaceutical Biotechnology of Faculty of Pharmacy of University of Coimbra. Thesis theme: "Multipotent mesenchymal stromal cells for Machado-Joseph disease therapy". September 2013¿ September 2014. (Co-supervisor: Luís Pereira de Almeida, PhD)
Orientador
Faculty of Pharmacy of University of Coimbra, Portugal

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação) 		Instituição / Organização
2026/03/26 - Atual Organizing committee of the Symposium ““Brain in Action – From Endogenous to Induced Brain Plasticity” Symposium (https://ibro.org/grant/speaker-support/#program-awardees). Supported by: IBRO and WWN (2025) (2026/03/26)
2025/09/18 - Atual Organizing Committee of the "Innovative Therapies 5th CiBB Retreat". (2025)
2022/10/28 - 2022/11/18 Organizing Committee of the “Well Being for Scientists @ CIBB” - event organized of the by the Post-Doc Representative Committee that consisted in a group of four sessions aiming at master communication skills, increase resilience at grant writing, finding balance in chaotic periods, among others (October 28 – November 18, 2022). (2022)

Participação em evento

Descrição da atividade
Tipo de evento 		Nome do evento
Instituição / Organização
2025 - Atual Participation in the enterpreneurial course EITHealth Top Femmale Founders Summer School 2025 (https://eithealth.eu/programmes/top-female-founders/). Online: 13 June – 4 July 2025; Onsite: 14 July – 18 July 2025 in Vienna, Austria.
2024/03 - Atual Scientific divulgation related activities, as part of the Program “Brain Awareness Week”, under the theme “Como Podemos Tornar o Nosso Cérebro Menos “Plástico”?” (March 2024). Basic school visits (Escola Básica e Secundária Quinta das Flores, Coimbra).
2022/10 - Atual Scientific divulgation related activities, as part of the “Festival Internacional de Ciência (FIC.A) 2022”, under the theme (Less)PlasticBrain (10 October 2022).
2022/10 - Atual Class given to celebrate the Stem Cell Day named “Células Estaminais: O que são, o que fazem, podem curar doenças do cérebro?” at the Basic School Areeiro, Coimbra, 2022.
2022/09 - Atual Scientific divulgation related activities, as part of the “Noite Europeia dos Investigadores (NEI)” and “FIC.A 2022”, under the theme Less Rare: Promovendo o Conhecimento da Doença de Machado-Joseph através da ARTE, da CIÊNCIA e da EDUCAÇÃO (September 2022).
2022/09 - Atual Class given to celebrate the Stem Cell Day named “Células Estaminais: O que são, o que fazem, podem curar doenças do cérebro?” at the Basic School of Mira, Coimbra, 2022.
2022/05 - Atual Class under the theme “Less PLastic Brain” given at the Basic School Areeiro (Coimbra), May 2022.
2022/02 - Atual Development of Educative Puzzles and a Quiz for children, under the thematic of the project “Less PLastic Brain”. February 2022
2022/02 - Atual Dance performance reproducing Machado-Joseph disease progression and symptoms “O cérebro a Caminho da Perfeição”, small video showing patients testimonials “Pessoas Raras movendo corações” and a public event clarifying some issues about the disease “Raro merece ser reconhecido” in FIC.A. (October 2022)
2018 - Atual Participation in tutorial and outreaching activities - Scientific initiative “Doença de Machado-Joseph: do Laboratório par a Sociedade” within Rare Diseases Day, 2018. (February 2018).
2015 - Atual “Postdoc@UC Day 2015 – Crossing Borders”, the annual event of the PostDoc@UC Initiative in October 30, 2015. Faculty of Arts and Humanities, Polo I, University of Coimbra, Portugal.
2020/10 - 2020/10 Participation in tutorial and outreaching activities - Scientific divulgation related activities, as part of the Program “Brain Awareness Week”, under the theme "A Viagem à Volta do Cérebro". Lecture on the topic "Células Estaminais: O Caso Particular das Células Mesenquimais na Doença de Machado-Joseph". Miranda CO. Escola Secundária Martim de Freitas, Coimbra (October 2020).
Seminário
 "Células Estaminais: O Caso Particular das Células Mesenquimais na Doença de Machado-Joseph"
2020 - 2020 Course on Computational Biology @ CNC – PDBEB 2020 Edition. UC-Biotech/CNC, Coimbra, Portugal (February 2020).
2020 - 2020 Participation in tutorial and outreaching activities - Scientific initiative “Doença de Machado-Joseph: do Laboratório par a Sociedade” within Rare Diseases Day, 2020. (February 2020).
2019 - 2019 Participation in tutorial and outreaching activities - Selfie Science video. Video explaining my research/activity in the lab for non-scientists: https://video.fopo1-1.fna.fbcdn.net/v/t42.9040-2/71982647_546754272728759_5038165357408288768_n.mp4?_nc_cat=111&efg=eyJ2ZW5jb2RlX3RhZyI6InN2ZV9zZCJ9&_nc_ohc=j13_p948dTAAX9u8duU&_nc_ht=video.fopo1-1.fna&oh=249ad2fc080c4b0658d06b59a94c592f&oe=5E5607E6
2019 - 2019 Participation in tutorial and outreaching activities - Scientific divulgation related activities, as part of the Program “Brain Awareness Week” (a global campaign to increase public awareness of the progress and benefits of brain research promoted internationally by Federation of European Neuroscience Societies (FENS) and DANA Foundation and nationally by Ciência Viva – Agência Nacional para a Cultura, Ciência e Tecnologia and Sociedade Portuguesa de Neurociências), under the theme “A Hora do Cérebro, Hora de Praticar o Certo” (March 2019).
2018 - 2018 Postdoc@UC 2018 Activities – Visual Communication in Science: Graphical Abstracts workshop. Institute for Interdisciplinary Research, Casa Costa Alemão, University of Coimbra, Portugal (April 17, 2018).
2018 - 2018 Participation in tutorial and outreaching activities - Scientific divulgation related activities, as part of the Program “Brain Awareness Week, under the theme “As Aventuras do Cérebro” (March 2018).
2017 - 2017 Participation in tutorial and outreaching activities - Scientific divulgation related activities, as part of the Program “Brain Awareness Week”, under the theme “As Viagens do Cérebro” (March 2017).
2016 - 2016 Workshop “Business Ideas Acceleration”, inserted in “Programa das sessões de Bioempreendedorismo para Investigadores do CNC”, at Pedro Nunes Institute, Coimbra, Portugal. January 2016.
2016 - 2016 JPND BIOMARKAPD Course “Biological markers in Neurological diseases - Present and Future approaches”, at CNC.IBILI, Coimbra, Portugal (2016).
2016 - 2016 Participation in tutorial and outreaching activities - Scientific divulgation related activities, as part of the “Noite Europeia dos Investigadores” (September 2016).
2015 - 2015 Participation in tutorial and outreaching activities - Scientific divulgation related activities, as part of the Program “Brain Awareness Week”, under the theme “Os cérebros andam aí... nas escolas”. Lecture on the topic "Células Estaminais: O Caso Particular das Células Mesenquimais na Doença de Machado-Joseph". Miranda CO. Escola Secundária Martim de Freitas, Coimbra (March 2015).
2014 - 2014 “Postdoc@UC Day 2014 – Building Networks”, the annual event of the PostDoc@UC Initiative in October 30, 2014. Faculty of Pharmacy, Polo III, University of Coimbra, Portugal.
2014 - 2014 Workshop “Células Estaminais: da investigação básica à aplicação terapêutica” at Centre of Blood and Transplantation of Coimbra, Portuguese Institute Institute of Blood and Transplantation, Coimbra, Portugal (2014).
2012 - 2012 “Advanced Fluorescence Microscopy Workshop” at CNCB, University of Coimbra, Coimbra, Portugal (2012).
2011 - 2011 Participation in tutorial and outreaching activities - Miranda C. Participation in the Educational Programme “Visitas das Escolas ao IBMC•INEB”, organized by the Office for Science Communication of the IBMC•INEB, with the lecture “How to Address Nerve Regeneration?” given to undergraduate students (April 2011).
2010 - 2010 “2nd Basic Course on Optical Microscopy Imaging for Biosciences” at IBMC, University of Porto, Porto, Portugal (2010).
2010 - 2010 Participation in tutorial and outreaching activities - Miranda C. Participation in the Educational Programme “Visitas das Escolas ao IBMC•INEB”, organized by the Office for Science Communication of the IBMC•INEB, with the lecture “How to Address Nerve Regeneration?” given to undergraduate students (April 2010).
2007 - 2007 Course “Stem Cells as a Tool in Toxicology” at the Centre for Neurosciences and Cell Biology, University of Coimbra, Coimbra, Portugal (2007).
2006 - 2006 Course “Stem Cells: Pitfalls and Successes” from the International Postgraduate Program Life and Health Sciences, at Instituto de Investigação em Ciências da Vida e da Saúde - ICVS, University of Minho, Braga, Portugal (2006).
2005 - 2005 Course “Finding Genes in Human Disease: from Genetics to Genomics” of the GABBA (University of Porto) and UniGENe (IBMC) Program, at IBMC, University of Porto, Porto, Portugal (2005).
2004 - 2004 “Advanced Course on Non-Viral Vectors for Application in Gene Therapy”, from the CNC International Doctoral Programme in Experimental Biology and Biomedicine, at University of Coimbra, Coimbra, Portugal (2004).
2002 - 2002 Albert Netter Journeys “Genetics and Biotechnology in Gynecology –from Diagnostic to Clinic”, at University of Coimbra, Coimbra, Portugal (2002).
2001 - 2001 Symposium “Horizontes da Genética”, at University of Coimbra, Coimbra, Portugal (2001).
1995 - 1995 “First Certificate in English" by the University of Cambridge, International. Examinations, Coimbra, Portugal (1995).

Arbitragem científica em conferência

Nome da conferência Local da conferência
2026/03/26 - Atual Scientific committee of the Symposium “Brain in Action – From Endogenous to Induced Brain Plasticity” Symposium (https://ibro.org/grant/speaker-support/#program-awardees). Supported by: IBRO and WWN (2025)
2025/11/17 - Atual Scientific committee. European Advanced Translational Medical Research Infrastructure (Eatris) ATMP Summit: The importance od advanced therapies in today's context. Co-organized by the (EATRIS) and the University of Coimbra (UC). November 2025
2025/09/18 - Atual Scientific Committee of the "Innovative Therapies 5th CiBB Retreat".
2016 - 2016 Organizing committee of the 1st International Symposium “Brain Without Borders – modelling, disease and repair, in collaboration with the Portuguese Societies for Stem Cells and Cell Therapies and Developmental Biology. http://www.uc.pt/en/iii/brain-without-borders Vectors and Gene Therapy Group, CNC and SPCE-TC

Arbitragem científica em revista

Nome da revista (ISSN) Editora
2025 - Atual Frontiers in Immunology. Co-Editor on the Research Topic: "Research Topic "Stem cells as immunological modulators in neurological and neurodegenerative conditions".
2023 - 2025 Frontiers in Genetics. Co-editor in the Research Topic: "Mesenchymal and induced-pluripotent stem cells as models to study biological processes”
2023 - 2024 Frontiers in Genetics

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2026/02/16 - Atual Co-coordination of a PHD Programme course - Programa Doutoral em Biologia Experimental e Biomedicina (PDBEB) Course 2025/2026: “Environmental and Metabolic Drivers of Physiological Decline, Center for Neuroscience and cell Biology, University of Coimbra, 16 - 20 February, 2026. Coordinators: Catarina Miranda, Cláudia F Pereira and Paula I Moreira.
2023/04/12 - Atual Lecture on the topic "Mesenchymal Stromal Cells: application to the Central Nervous System and the Particular Case of Machado-Joseph Disease", integrated in the curricular unit “Terapêutica Molecular e Engenharia de Tecidos” of the Master in Pharmaceutical Biotechnology – Faculty of Pharmacy, University of Coimbra (2023).
2022/04/18 - Atual Lecture on the topic "Mesenchymal Stem Cells for Brain Disorders – the Particular case of Machado-Joseph Disease", integrated in the course "Advanced Therapies" of the Doctoral Program in Experimental Biology and Biomedicine (PDBEB) - CNC, University of Coimbra, Coimbra, Portugal (2022).
2021/04/20 - Atual Lecture on the topic "Mesenchymal Stem Cells for Brain Disorders – the Particular case of Machado-Joseph Disease", integrated in the course "Advanced Therapies" of the Doctoral Program in Experimental Biology and Biomedicine (PDBEB) - CNC, University of Coimbra, Coimbra, Portugal (2021).
2021/04/12 - Atual Lecture on the topic "Mesenchymal Stem Cells in Brain Disorders", integrated in the curricular unit “Terapêutica Molecular e Engenharia de Tecidos” of the Master in Pharmaceutical Biotechnology – Faculty of Pharmacy, University of Coimbra (2021).
2020/04 - Atual Miranda CO. Lecture on the topic "Mesenchymal Stromal Cells: application to the Central Nervous System.", integrated in the curricular unit "Terapêutica Molecular e Engenharia de Tecidos" of the Master in Pharmaceutical Biotechnology of Faculty of Pharmacy, University of Coimbra (2020). Master
2020/12/18 - 2020/12/18 Seminar given under the topic "Células Estaminais: O Caso Particular Da Aplicacação das Células Mesenquimatosas na Doença de Machado-Joseph", to the Undergraduation in Biomedical Sciences, Gene and Cell Therapy Curricular Unit, Faculty of Medicine and Biomedical Sciences, University of Algarve, Portugal. (Licenciatura)
2019 - 2019 Miranda CO. Lecture on the topic "Mesenchymal Stromal Cells: application to the Central Nervous System and the Particular Case of Machado-Joseph Disease", integrated in the curricular unit “Terapêutica Molecular e Engenharia de Tecidos” of the Master in Pharmaceutical Biotechnology – Faculty of Pharmacy, University of Coimbra (2019). (Mestrado)
2019 - 2019 Miranda CO. Lecture on the topic "Mesenchymal Stem Cells in Brain Disorders", integrated in the course "Advanced Therapies" of the Doctoral Program in Experimental Biology and Biomedicine (PDBEB) - CNC, University of Coimbra, Coimbra, Portugal (2019). (Doutoramento)
2018 - 2018 Miranda CO. Lecture on the topic "Mesenchymal Stromal Cells: application to the Central Nervous System", integrated in the curricular unit “Terapêutica Molecular e Engenharia de Tecidos” of the Master in Pharmaceutical Biotechnology – Faculty of Pharmacy, University of Coimbra (2018). (Mestrado)
2017 - 2017 Miranda CO. Lecture on the topic "Mesenchymal Stromal Cells: application to the Central Nervous System", integrated in the curricular unit “Terapêutica Molecular e Engenharia de Tecidos” of the Master in Pharmaceutical Biotechnology – Faculty of Pharmacy, University of Coimbra (2017). (Mestrado)
2016 - 2016 Miranda CO. Lecture on the topic "Mesenchymal Stem Cells in Brain Disorders", integrated in the course "Gene and Cell Therapy" of the Doctoral Program in Experimental Biology and Biomedicine (PDBEB) - CNCB, University of Coimbra, Coimbra, Portugal (2016). (Doutoramento)
2015 - 2015 Miranda CO. Lecture on the topic "Stem Cells: the case of MSCs", integrated in the curricular unit “Terapêutica Molecular e Engenharia de Tecidos” of the Master in Pharmaceutical Biotechnology – Faculty of Pharmacy, University of Coimbra (2015). (Mestrado)
2014 - 2014 Miranda CO. Lecture on the topic "Stem Cells: the case of MSCs", integrated in the curricular unit “Terapêutica Molecular e Engenharia de Tecidos” of the Master in Pharmaceutical Biotechnology – Faculty of Pharmacy, University of Coimbra (2014). (Mestrado)
2013 - 2013 Miranda CO. Lecture on the topic "Stem Cells: the case of MSCs", integrated in the curricular unit “Terapêutica Molecular e Engenharia de Tecidos” of the Master in Pharmaceutical Biotechnology – Faculty of Pharmacy, University of Coimbra (2013). (Mestrado)
2013 - 2013 Miranda CO. Lecture on the topic "Stem Cells: the case of MSCs", integrated in the course "Gene and Cell Therapy" of the Doctoral Program in Experimental Biology and Biomedicine (PDBEB) - CNCB, University of Coimbra, Coimbra, Portugal (2013). (Doutoramento)

Membro de associação

Nome da associação Tipo de participação
2022/01/16 - Atual ALBA Network – Towards Diversity and Equity in Brain Sciences Leader of a new ALBA Working Group on Disabilities, aiming at promoting a greater inclusion and well-being of neuroscientists with disabilitie
2018 - Atual Federation of European Neuroscience Societies (FENS)
2018 - Atual European Society of Gene and Cell Therapy (ESGCT)
2012 - Atual Portuguese Society for Neuroscience (SPN), FENS affiliate.
2006 - Atual Portuguese Society for Stem Cells and Cellular Therapy (SPCETC).
2015 - 2020 International Society of Stem Cell Research (ISSCR) and European Society of Gene and Cell Therapy, (ESGCT, ISSCR affiliate).
2012 - 2020 Society for Neuroscience (SFN).

Membro de comissão

Descrição da atividade
Tipo de participação 		Instituição / Organização
2025/06 - Atual Member of the PhD Thesis Monitoring Committee in Biomedicine, University of Beira Interior (UBI) – responsible for the annual evaluation of the PhD project progress of Beatriz Lopes Araújo. Thesis topic: “Stem Cell Secretome Therapy for Ischemic Brain Injury: From Cord to Cure.” Started in June 2025.
2024 - Atual Ambassador of ALBA Network - Towards Diversity and Equity in Brain Sciences (2024 - present).
2022 - Atual Greenkeeper at GreenLabsCiBB (https://cnc.uc.pt/pt/green-labs), CNC-UC, Portugal (2022 - present).
2022 - Atual Co-Chair of the Disability & Accessibility Working Group of ALBA Network – Towards Diversity and Equity in Brain Sciences (2022 - present).
2025/09 - 2025/09 Committee of Master Thesis Defence of Catarina Oliveira. Thesis tittle: “Glycopolymers to prevent beta-amyloid aggregation and related neurotoxicity.” September 2025.
2024/10 - 2024/10 Committee of Master Thesis Defence of Emanuel Cardoso. Thesis tittle: “COMBATENDO A DOENÇA DE ALZHEIMER USANDO COPOLÍMEROS MULTIVALENTES”. October 2024.
2024/10 - 2024/10 Committee of Master Defence of Ana Luísa de Oliveira Valério. Thesis tittle: “Desenvolvimento e translação para Boas Práticas de Fabrico de um medicamento de terapia avançada para o tratamento de lesões da cartilagem do joelho”. October 2024.
2021 - 2023 Post-Doctoral Representative at Centre for Innovative Biomedicine and Biotechnology (CIBB) (2021-2023).
2022/09 - 2022/09 Committee of Master Thesis Defence of Maria Casquinha. Thesis tittle: “THE IMPACT OF POSTNATAL ALLERGIES IN MICROGLIA-MEDIATED CEREBELLAR MATURATION”. September 2022.
2021/10 - 2021/10 Committee of Master Thesis Defence of Margarida Pargana. Thesis tittle: “Advanced Therapies in Type 1 Diabetes: Cell Reprogramming”. October 2021.

Revisão ad hoc de artigos em revista

Nome da revista (ISSN) Editora
2025/09 - 2025/09 Journal of Neurochemistry
2025/03 - 2025/03 Biomolecules
2023 - 2023 Journal of Clinical Medicine
2022/06 - 2022/06 Healthcare
2022/02 - 2022/02 Life
2021/11 - 2021/11 Biomedicines
2021/09 - 2021/09 Biomedicines
2021/04 - 2021/04 Cells
2021/01 - 2021/01 Cells
2020/12 - 2020/12 Dr. Sulaiman Al Habib Medical Journal (2590-3349 ) Atlantis Press
2020/12 - 2020/12 Neural Regeneration Research (1673-5374) Publishing House of Neural Regeneration Research China Association of Rehabilitation Medicine, China
2020/11 - 2020/11 Neurology and Clinical Neuroscience (2049-4173) Wiley Online Library
2019 - 2019 Frontiers in Cellular Neuroscience (1662-5102) Frontiers Media SA
2014 - 2014 Cell Transplantation (1555-3892) SAGE Publications

Tutoria

Tópico Nome do aluno
2023/05 - 2023/07 Mentoring of André Pinto. Undergraduate student. Thesis theme: “Optimization of a pipeline for human induced pluripotent stem cells- derived neurons characterization after exposure to fossil-based and bio- based plastic additives.” André Pinto
2020/08/01 - 2020/10/31 Supervision of Daniela Gonzaga under the Scientific Research Methodologies Summer Course-I&D: Gene Therapy and Stem Cells, awarded with FCT fellowship - “Evaluating whether mutant ataxin-3 comprise the therapeutic potential of mesenchymal stromal cells". Daniela Gonzaga
2020/08/01 - 2020/10/31 Supervision of António Silva under the Scientific Research Methodologies Summer Course-I&D: Gene Therapy and Stem Cells (FCT fellowship) - “Evaluation of Autophagy in the Cerebellum of Macahado-joseph Disease Mice Treated with Mesenchymal Stromal Cells". António Silva
2020/02 - 2020/07 Ungraduated Student Training (António Silva). B. Sc. Final Work entitled “Therapeutic application of Mesenchymal Stem Cells for the treatment of COVID-19”, to obtain the bachelor’s degree in Biomechemistry of University of Coimbra. February - July 2020. António Silva
2020/01 - 2020/02 Master Student Training (Luís Miguel). Luís Miguel
2020/01 - 2020/02 Master Student Training (Henrique Duarte). Henrique Duarte
2017/04 - 2017/06 Undergraduate Student Training (Ana Rita Rosa, B. Sc.). Final Work entitled "Unraveling whether mutant ataxin-3 can compromise the therapeutic potential of mesenchymal stromal cells in Machado Joseph disease". Ana Rita Rosa
2016/05 - 2016/07 Undergraduate Student Training (Joana Filipa Catarino Alves, B. Sc.). Final Work entitled "Potential therapeutic effect of mesenchymal stromal cells in alleviating the neuropathological impairments in a lentiviral-induced mouse model of MJD". Joana Filipa Catarino Alves
2015/05 - 2015/06 Master Student Training (Anna Pliássova). Final Work entitled: “Evaluation of the systemic delivery of mesenchymal stromal cells for Machado-Joseph Disease" Anna Pliássova
2015/02 - 2015/03 Master Student Training (João Miguel do Cruzeiro). Final work entitled: "Mesenchymal stem cells for Machado-Joseph disease." João Miguel do Cruzeiro
2015/02 - 2015/03 Master Student Training (Adriana Isabel do Vale Marcelo). Final Work entitled: “Mesenchymal stem cells for Machado-Joseph disease". Adriana Isabel do Vale Marcelo
2014/09 - 2014/11 PhD Student Training (Raquel Cunha). Final work under the topic: "Towards the treatment of Machado-Joseph disease using Mesenchymal Stem Cells." Raquel Cunha
2014/06 - 2014/08 PhD Student Training (Maria João Bastos). Final work under the topic: "Mesenchymal Stem Cell transplantation: a novel therapeutic strategy for MJD? A preliminary study in lentiviral MJD mouse model." Maria João Bastos
2010/05 - 2010/06 Undergraduate Student Training (Peter McCarthy). Work entitled: "How can mesenchymal stem cells help Leukodystrophies?". Peter McCarthy
Distinções

Prémio

2025 International Brain Research Organization (IBRO) Speaker Support - IBRO Speaker Support (2.5K €) to promote the “Brain in Action – From Endogenous to Induced Brain Plasticity” Symposium (https://ibro.org/grant/speaker-support/#program-awardees). 2025
International Brain Research Organization, França
2025 World Women in Neuroscience (WWN) Global Connectome 2026 (1K €). Support to promote the “Brain in Action – From Endogenous to Induced Brain Plasticity” Symposium. Supported by: WWN (2025)
World Women in Neuroscience (WWN), Estados Unidos
2025 Third place award on the Pitch Presentation on the EIT Health Top Femmale Founders Summer School 2025.
2023 SPN Initiatives Support (0.5k €)
Sociedade Portuguesa de Neurociências, Portugal
2022 Brain Awareness Week grant (1K €)
Dana Foundation and FENS , França
2021 ESCI Young Investigator Award 2021, awarded from the European Society of Clinical Investigation (ESCI) - 2nd place. Announcement in April 2021.
2021 Young Investigator Award by New York Academy of Sciences (NYAS) and the Japan Agency for Medical Research and Development (AMED) to participate in the Interstellar Initiative
2019 Contract as a Researcher (under the DL-57/2016 scientific employment) to work in the project "Mesenchymal stem cells for Machado-Joseph disease therapy".
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2018 Conference Fellowship Award to participate in the 1st international symposium Secretome With]Out[ Borders, in Braga, Portugal
Sociedade Portuguesa de Neurociências, Portugal
2013 Best ‘Art and Science’ Exhibition/Competition in the Centre for Neurosciences and Cell Biology (CNC) Annual Meeting
PhD Programme Experimental Biology and Biomedicine (BEB) (2013)., Portugal
2012 Research fellowship on the project “Dissecting the pathogenesis of Machado-Joseph disease in a new human disease model derived from induced pluripotent stem cells” (PTDC/SAU-NMC/116512/2010)
Fundação para a Ciência e a Tecnologia, Portugal
2012 Post-Doc fellowship (SFRH / BPD / 87732 / 2012). Research project: “Mesenchymal Stem Cells for Machado-Joseph Disease”.
Fundação para a Ciência e a Tecnologia, Portugal
2011 Research fellowship on the project “Dissecting nerve regeneration and the neuritogenic activity of TTR” (PTDC/SAU-GMG/111761/2009)
Fundação para a Ciência e a Tecnologia, Portugal
2011 Cover in Stem Cells Journal - November 2011, volume 29, Issue 11
2010 Best Poster Presentation Award in the 6th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies (SPCE-TC), Cantanhede, Portugal.
Portuguese Society for Stem Cells and Cell Therapies , Portugal
2010 Best Poster Presentation Award in the 1st I3S IBMC/INEB/IPATIMUP Together in Science Meeting, Póvoa de Varzim, Portugal.
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2010 Funds for Junior Investigators Award to participate in the Gordon Research Conference (GRC) on Myelin, Ventura Beach, CA, USA.
Gordon Research Conference (GRC) on Myelin, Estados Unidos
2007 Best Oral Communication Award in the V Simpósio da Sociedade Portuguesa de Doenças Metabólicas, Porto, Portugal.
Sociedade Portuguesa de Doenças Metabólicas, Portugal
2006 Research Internship to Work on the Project “Evaluation of Cellular Therapy in Leuk System Demyelination”
Instituto de Emprego Profissional and Instituto de Biologia Molecular e Celular (IBMC), Portugal
2006 PhD fellowship (SFRH / BD / 29768 / 2006) with the project entitled "“Evaluation of Cellular Therapy in Leukodystrophies with Peripheral Nervous System Demyelination”.
Fundação para a Ciência e a Tecnologia, Portugal
2005 Fellowship For Training Abroad of Calouste Gulbenkian Foundation (FCG), Portugal.
Fundação Calouste Gulbenkian, Portugal

Outra distinção

2025 Waived fee to participate in the "5th Workshop on Neuroengineering: AI tools in Neuroscience" I3S, Porto (2025)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2025 Selected short-talk to present at the 5th Workshop on Neuroengineering: AI tools in Neuroscience (I3S, Porto). Talk title: Transcription Factor-Mediated Glial Reprogramming as a Therapeutic Strategy for Machado-Joseph Disease.
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2025 Selection to participate in the EITHealth Top Femmale Founders Summer School 2025 (https://eithealth.eu/programmes/top-female-founders/). Hotel and meals provided. Waarded by: EIT Health. June 2025