???global.info.a_carregar???
Identificação

Identificação pessoal

Nome completo
Joao Goncalves

Nomes de citação

  • Goncalves, Joao

Identificadores de autor

Ciência ID
B11B-9815-C46F
ORCID iD
0000-0002-1245-3715

Endereços de correio eletrónico

  • joao.goncalves@ff.ul.pt (Profissional)

Telefones

Telefone
  • (351) 217946486 (Profissional)

Moradas

  • Faculdade Farmácia Universidade Lisboa, 1649-019, Lisboa, Lisboa, Portugal (Profissional)

Websites

Domínios de atuação

  • Ciências Médicas e da Saúde - Biotecnologia Médica - Biotecnologia Aplicada à Saúde

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português (Idioma materno)
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Formação
Grau Classificação
2012
Concluído
 Ciencias Farmaceuticas (Título de Agregado)
Especialização em microbiologia
Universidade de Lisboa Faculdade de Farmácia, Portugal
1996/03/22
Concluído
 Ciências Farmacêuticas (Doutoramento)
Especialização em Virologia
Universidade de Lisboa Faculdade de Farmácia, Portugal
"Functional analysis of HIV-1 Vif protein" (TESE/DISSERTAÇÃO)
1990/03/28
Concluído
 Ciências Farmacêuticas (Licenciatura)
Especialização em microbiologia
Universidade de Lisboa Faculdade de Farmácia, Portugal
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2000 - 2003 Investigador visitante (Investigação) Scripps Research Institute, Estados Unidos
Scripps Research Institute, Estados Unidos
1990 - 1996 Investigador (Investigação) Harvard Medical School, Estados Unidos
Dana Farber Cancer Institute, Estados Unidos

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2021 - Atual Professor Catedrático (Docente Universitário) Universidade de Lisboa Faculdade de Farmácia, Portugal
Universidade de Lisboa Faculdade de Farmácia, Portugal
2006/03/01 - 2020/12/31 Professor Associado (Docente Universitário) Universidade de Lisboa Faculdade de Farmácia, Portugal
Universidade de Lisboa Faculdade de Farmácia, Portugal
2004/01/01 - 2005/12/31 Professor Auxiliar (Docente Universitário) Universidade de Lisboa Faculdade de Farmácia, Portugal
Universidade de Lisboa Faculdade de Farmácia, Portugal

Outras Carreiras

Categoria Profissional
Instituição de acolhimento 		Empregador
1998 - 2000 Técnico Superior (Técnico Superior) Merck Sharp & Dohme Corp, Estados Unidos
Merck Sharp & Dohme Corp, Estados Unidos
1997 - 1998 Assessor sénior (Farmacêutica) Biologie Servier, França
Biologie Servier, França
Projetos

Bolsa

Designação Financiadores
2014/05 - 2016/04 Artificial Zinc-Finger transcription factors libraries: Identification of HIV-1 cellular restriction factors and Therapeutic application in HIV-1 infection.
Provided by PTCRIS: 123645
123645
 Fundação para a Ciência e a Tecnologia, I.P.
2014/03 - 2016/02 An innovative approach to deliver dual-targeting HIV entry inhibitors using cationic liposomes
Provided by PTCRIS: 135858
135858
 Fundação para a Ciência e a Tecnologia, I.P.
2012/01 - 2014/12 ArmAb: New strategy of ADC for arming antibodies in cancer therapy
119173
Provided by PTCRIS: 119173
 Fundação para a Ciência e a Tecnologia, I.P.
2013/04 - 2014/09 PhageDuction: a new bacteriophage-based technology for efficient cell-targeted DNA delivery
Provided by PTCRIS: 125218
125218
 Fundação para a Ciência e a Tecnologia, I.P.
2011/03 - 2014/08 Albumin binding-domain fusions to improve protein pharmacokinetics
Provided by PTCRIS: 115846
115846
 Fundação para a Ciência e a Tecnologia, I.P.
2009/01 - 2012/06 Biomolecular Engineering Approches for in vitro Production of Self Assembly Viral Nanoparticles
Provided by PTCRIS: 69682
69682
 Fundação para a Ciência e a Tecnologia, I.P.
2008/03 - 2011/07 Regulation of intracellular anti-viral defense factor APOBEC3G as therapeutic strategy to control HIV-1 infection.
74613
Provided by PTCRIS: 74613
 Fundação para a Ciência e a Tecnologia, I.P.
2008/01 - 2011/04 A Novel Lentiviral Target-Specific Strategy for Molecular and Gene Therapy
Provided by PTCRIS: 64275
64275
 Fundação para a Ciência e a Tecnologia, I.P.
2008/03 - 2011/02 Screening the role of kinases/phosphatases in early stages of HIV-1 infection using shRNA-encoded lentiviral libraries.
65346
Provided by PTCRIS: 65346
 Fundação para a Ciência e a Tecnologia, I.P.
2007/08 - 2011/02 Genome-wide screening with libraries of synthetic zinc-finger proteins capable to modulate host gene expression: Application in HIV-1 infection.
71599
Provided by PTCRIS: 71599
 Fundação para a Ciência e a Tecnologia, I.P.
2007/01 - 2008/10 Cytidine deaminases as players in intracellular immunity to retroviruses: Mechanisms and Regulation
Provided by PTCRIS: 82621
82621
 Fundação para a Ciência e a Tecnologia, I.P.
2005/06 - 2008/06 Viral Nanopaticles por Molecular and Gene Therpay
Provided by PTCRIS: 62476
62476
 Fundação para a Ciência e a Tecnologia, I.P.
2005/05 - 2006/12 Cytidine deaminases as players in intracellular immunity to retroviruses: Mechanisms and Regulation
60038
Provided by PTCRIS: 60038
 Fundação para a Ciência e a Tecnologia, I.P.
2003/12 - 2006/05 Inhibition of HIV infectivity by single-domain antibodies.
Provided by PTCRIS: 49729
49729
 Fundação para a Ciência e a Tecnologia, I.P.
2002/05 - 2004/04 Inhibition of Kaposis's sarcoma-associated herpes virus latency by intracellular antibodies
Provided by PTCRIS: 38229
38229
 Fundação para a Ciência e a Tecnologia, I.P.
2001/02 - 2004/01 INTRACELLULAR IMMUNIZATION FOR AIDS THERAPY: TARGETING HIV INFECTIVITY
Provided by PTCRIS: 33096
33096
 Fundação para a Ciência e a Tecnologia, I.P.

Projeto

Designação Financiadores
2022/01/01 - 2024/12/31 BREAST-BRAIN-N-BBB
BREAST-BRAIN-N-BBB
Investigador
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
 CaixaForum Barcelona
Em curso
2020/06/01 - 2023/03/31 Testimmuno Covid19: Avaliação da resposta imunitária e virológica em doentes Covid19 e pessoas vacinadas.
AAC 02/SAICT/2020
Investigador responsável
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
 Fundação para a Ciência e a Tecnologia, I.P.
Em curso
2018 - 2020 Engineering novel ADC with potent immune functions
PF029145
Investigador responsável
Em curso
2015 - 2016 Drug repositioning: Re-investigating existing drugs for treatment and functional cure of HIV-1 infection
OP23713
Investigador responsável
Concluído
Produções

Publicações

Artigo em conferência
  1. Condelipes, P.G.M.; Fontes, P.M.; Nikolaidou, K.; Marques, V.; Bras, E.J.S.; Afonso, M.B.; Rodrigues, C.M.P.; et al. "Development of a Microfluidic Colorectal Cancer Cell Culture System with Integrated Optical Sensors for Rapid Phage Selection". 2020.
    10.1109/SENSORS47125.2020.9278738
Artigo em revista
  1. Barros, Ana Luisa A. N.; Silva, Vladimir C.; Ribeiro-Junior, Atvaldo F.; Cardoso, Miguel G.; Costa, Samuel R.; Moraes, Carolina B.; Barbosa, Cecília G.; et al. "Antiviral Action against SARS-CoV-2 of a Synthetic Peptide Based on a Novel Defensin Present in the Transcriptome of the Fire Salamander (Salamandra salamandra)". Pharmaceutics 16 2 (2024): 190. http://dx.doi.org/10.3390/pharmaceutics16020190.
    10.3390/pharmaceutics16020190
  2. Clare Harris; Richard James Harris; David Young; Martin McDonnell; Bridget Clancy; Justin Harvey; Carlos Araujo; et al. "Clinical Outcomes and Patient Experience of Biosimilar to Biosimilar Infliximab Switching in Patients with Inflammatory Bowel Disease: A Prospective, Single-Centre, Phase IV Interventional Study with a Nested Qualitative Study". GastroHep (2023): https://doi.org/10.1155/2023/1248526.
    10.1155/2023/1248526
  3. Brás, R.; Goncalves, J.; Araújo, C.; Godinho Santos, A.; Costa, L.; Pedro, E.; Caiado, J.. "sIgE/sIgG4 profile in platinum desensitization: is there immunological tolerance?". European Annals of Allergy and Clinical Immunology online fir (2023): http://dx.doi.org/10.23822/eurannaci.1764-1489.302.
    10.23822/eurannaci.1764-1489.302
  4. Simão, André Lopes; Palma, Carolina Santos; Izquierdo-Sanchez, Laura; Putignano, Antonella; Carvalho-Gomes, Angela; Posch, Andreas; Zanaga, Paola; et al. "Cirrhosis is associated with lower serological responses to COVID-19 vaccines in patients with chronic liver disease". JHEP Reports 5 5 (2023): 100697. http://dx.doi.org/10.1016/j.jhepr.2023.100697.
    10.1016/j.jhepr.2023.100697
  5. André, Ana S.; Dias, Joana N. R.; Aguiar, Sandra; Nogueira, Sara; Bule, Pedro; Carvalho, Joana Inês; António, João P. M.; et al. "Rabbit derived VL single-domains as promising scaffolds to generate antibody–drug conjugates". Scientific Reports 13 1 (2023): http://dx.doi.org/10.1038/s41598-023-31568-x.
    10.1038/s41598-023-31568-x
  6. Figueiredo, Diogo; Cascalheira, António; Goncalves, Joao. "Rapid, multiplex detection of SARS-CoV-2 using isothermal amplification coupled with CRISPR-Cas12a". Scientific Reports 13 1 (2023): http://dx.doi.org/10.1038/s41598-022-27133-7.
    10.1038/s41598-022-27133-7
  7. Zvonimir Petric; Joao Goncalves; Paulo Paixao. "Under the Umbrella of Clinical Pharmacology: Inflammatory Bowel Disease, Infliximab and Adalimumab, and a Bridge to an Era of Biosimilars". Pharmaceutics (2022): https://doi.org/10.3390/pharmaceutics14091766.
    10.3390/pharmaceutics14091766
  8. Iria, I.; Soares, R.R.G.; Brás, E.J.S.; Chu, V.; Gonçalves, J.; Conde, J.P.. "Accurate and rapid microfluidic ELISA to monitor Infliximab titers in patients with inflammatory bowel diseases". Analyst 147 3 (2022): 480-488. http://www.scopus.com/inward/record.url?eid=2-s2.0-85123969178&partnerID=MN8TOARS.
    10.1039/d1an01810h
  9. Schreiber, S.; Puig, L.; Gonçalves, J.; Mease, P.J.; Panaccione, R.; Emery, P.. "Critical appraisal and future outlook on anti-inflammatory biosimilar use in chronic immune-mediated inflammatory diseases". Seminars in Arthritis and Rheumatism 55 (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85131446689&partnerID=MN8TOARS.
    10.1016/j.semarthrit.2022.152023
  10. Bandarra, Susana; Miyagi, Eri; Ribeiro, Ana Clara; Gonçalves, João; Strebel, Klaus; Barahona, Isabel. "APOBEC3B Potently Restricts HIV-2 but Not HIV-1 in a Vif-Dependent Manner". Journal of Virology 95 23 (2021): http://dx.doi.org/10.1128/jvi.01170-21.
    10.1128/jvi.01170-21
  11. "Highly Specific Blood-Brain Barrier Transmigrating Single-Domain Antibodies Selected by an In Vivo Phage Display Screening". Pharmaceutics 13 10 (2021): 1598-1598. http://dx.doi.org/10.3390/pharmaceutics13101598.
    10.3390/pharmaceutics13101598
  12. "Biosimilars in an era of rising oncology treatment options". Future Oncology 17 29 (2021): 3881-3892. http://dx.doi.org/10.2217/fon-2021-0546.
    10.2217/fon-2021-0546
  13. "Methods and cell-based strategies to produce antibody libraries: current state". Applied Microbiology and Biotechnology 105 19 (2021): 7215-7224. http://dx.doi.org/10.1007/s00253-021-11570-x.
    10.1007/s00253-021-11570-x
  14. "A purification platform for antibodies and derived fragments using a de novo designed affinity adsorbent". Separation and Purification Technology 265 (2021): 118476-118476. http://dx.doi.org/10.1016/j.seppur.2021.118476.
    10.1016/j.seppur.2021.118476
  15. "Integrated in Silico and Experimental Approach towards the Design of a Novel Recombinant Protein Containing an Anti-HER2 scFv". International Journal of Molecular Sciences 22 7 (2021): 3547-3547. http://dx.doi.org/10.3390/ijms22073547.
    10.3390/ijms22073547
  16. "Screening polymeric ionic liquids for chromatography-based purification of bacteriophage M13". Separation and Purification Technology 257 (2021): 117906-117906. http://dx.doi.org/10.1016/j.seppur.2020.117906.
    10.1016/j.seppur.2020.117906
  17. "Systematic Review and Principal Components Analysis of the Immunogenicity of Adalimumab.". BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy (2021): https://doi.org/10.1007/s40259-020-00458-3.
    10.1007/s40259-020-00458-3
  18. Cerván-Martín, M.; Bossini-Castillo, L.; Rivera-Egea, R.; Garrido, N.; Luján, S.; Romeu, G.; Santos-Ribeiro, S.; et al. "Effect and in silico characterization of genetic variants associated with severe spermatogenic disorders in a large Iberian cohort". Andrology 9 4 (2021): 1151-1165. http://www.scopus.com/inward/record.url?eid=2-s2.0-85112490115&partnerID=MN8TOARS.
    10.1111/andr.13009
  19. Park, K.; Li, C.; Tsiropoulou, S.; Gonçalves, J.; Kondratev, C.; Pelletier, L.; Blacque, O.E.; Leroux, M.R.. "CDKL kinase regulates the length of the ciliary proximal segment". Current Biology 31 11 (2021): 2359-2373.e7. http://www.scopus.com/inward/record.url?eid=2-s2.0-85105010786&partnerID=MN8TOARS.
    10.1016/j.cub.2021.03.068
  20. Holgersen, E.M.; Gandhi, S.; Zhou, Y.; Kim, J.; Vaz, B.; Bogojeski, J.; Bugno, M.; et al. "Transcriptome-Wide Off-Target Effects of Steric-Blocking Oligonucleotides". Nucleic Acid Therapeutics 31 6 (2021): 392-403. http://www.scopus.com/inward/record.url?eid=2-s2.0-85121681071&partnerID=MN8TOARS.
    10.1089/nat.2020.0921
  21. Vale, F.F.; Vítor, J.M.B.; Marques, A.T.; Azevedo-Pereira, J.M.; Anes, E.; Goncalves, J.. "Origin, phylogeny, variability and epitope conservation of SARS-CoV-2 worldwide". Virus Research 304 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85111961673&partnerID=MN8TOARS.
    10.1016/j.virusres.2021.198526
  22. Cadima-Couto, Iris; Tauzin, Alexandra; Freire, João M.; Figueira, Tiago N.; Silva, Rúben D. M.; Pérez-Peinado, Clara; Cunha-Santos, Catarina; et al. "Anti-HIV-1 Activity of pepRF1, a Proteolysis-Resistant CXCR4 Antagonist Derived from Dengue Virus Capsid Protein". ACS Infectious Diseases 7 1 (2020): 6-22. http://dx.doi.org/10.1021/acsinfecdis.9b00507.
    10.1021/acsinfecdis.9b00507
  23. Strand, Vibeke; Goncalves, Joao; Isaacs, John D.. "Immunogenicity of biologic agents in rheumatology". Nature Reviews Rheumatology 17 2 (2020): 81-97. http://dx.doi.org/10.1038/s41584-020-00540-8.
    10.1038/s41584-020-00540-8
  24. St Clair-Jones, Anja; Prignano, Francesca; Goncalves, Joao; Paul, Muriel; Sewerin, Philipp. "Understanding and Minimising Injection-Site Pain Following Subcutaneous Administration of Biologics: A Narrative Review". Rheumatology and Therapy 7 4 (2020): 741-757. http://dx.doi.org/10.1007/s40744-020-00245-0.
    10.1007/s40744-020-00245-0
  25. Cascão, Rita; Vidal, Bruno; Carvalho, Tânia; Lopes, Inês Pascoal; Romão, Vasco C.; Goncalves, João; Moita, Luis Ferreira; Fonseca, João Eurico. "Celastrol Efficacy by Oral Administration in the Adjuvant-Induced Arthritis Model". Frontiers in Medicine 7 (2020): http://dx.doi.org/10.3389/fmed.2020.00455.
    10.3389/fmed.2020.00455
  26. Perdigão, Pedro R.L.; Cunha-Santos, Catarina; Barbas, Carlos F.; Santa-Marta, Mariana; Goncalves, Joao. "Protein Delivery of Cell-Penetrating Zinc-Finger Activators Stimulates Latent HIV-1-Infected Cells". Molecular Therapy - Methods & Clinical Development 18 (2020): 145-158. http://dx.doi.org/10.1016/j.omtm.2020.05.016.
    10.1016/j.omtm.2020.05.016
  27. Lüftner, Diana; Lyman, Gary H.; Gonçalves, João; Pivot, Xavier; Seo, Minji. "Biologic Drug Quality Assurance to OptimizeHER2¿+¿Breast Cancer Treatment: Insights from Development of the Trastuzumab BiosimilarSB3". Targeted Oncology 15 4 (2020): 467-475. http://dx.doi.org/10.1007/s11523-020-00742-w.
    10.1007/s11523-020-00742-w
  28. Santos, Raquel dos; Iria, Inês; Manuel, Ana M.; Leandro, Ana P.; Madeira, Catarina A. C.; Goncalves, Joao; Carvalho, Ana Luísa; Roque, Ana Cecília A.. "Magnetic Precipitation: A New Platform for Protein Purification". Biotechnology Journal 15 9 (2020): http://dx.doi.org/10.1002/biot.202000151.
    10.1002/biot.202000151
  29. Goncalves, Joao. "Protein delivery of cell-penetrating zinc-finger activators stimulates latent HIV-1 infected cells". Molecular Therapy - Methods & Clinical Development MTM-D-20-0 Accepted (2020):
  30. Ministro, Joana H.; Oliveira, Soraia S.; Oliveira, Joana G.; Cardoso, Miguel; Aires-da-Silva, Frederico; Corte-Real, Sofia; Goncalves, Joao. "Synthetic antibody discovery against native antigens by CRISPR/Cas9-library generation and endoplasmic reticulum screening". Applied Microbiology and Biotechnology 104 6 (2020): 2501-2512. http://dx.doi.org/10.1007/s00253-020-10423-3.
    10.1007/s00253-020-10423-3
  31. Strand, V.; Gonçalves, J.; Hickling, T.P.; Jones, H.E.; Marshall, L.; Isaacs, J.D.. "Correction to: Immunogenicity of Biosimilars for Rheumatic Diseases, Plaque Psoriasis, and Inflammatory Bowel Disease: A Review from Clinical Trials and Regulatory Documents (BioDrugs, (2020), 34, 1, (27-37), 10.1007/s40259-019-00394-x)". BioDrugs 34 2 (2020): 253-253. http://www.scopus.com/inward/record.url?eid=2-s2.0-85080149855&partnerID=MN8TOARS.
    10.1007/s40259-020-00410-5
  32. Lüftner, D.; Lyman, G.H.; Gonçalves, J.; Pivot, X.; Seo, M.. "Correction to: Biologic Drug Quality Assurance to Optimize HER2+ Breast Cancer Treatment: Insights from Development of the Trastuzumab Biosimilar SB3 (Targeted Oncology, (2020), 15, 4, (467-475), 10.1007/s11523-020-00742-w)". Targeted Oncology 15 6 (2020): 805-805. http://www.scopus.com/inward/record.url?eid=2-s2.0-85092798366&partnerID=MN8TOARS.
    10.1007/s11523-020-00761-7
  33. Ferrasi, A.C.; Fernandez, G.J.; Grotto, R.M.T.; Silva, G.F.; Goncalves, J.; Costa, M.C.; Enguita, F.J.; Pardini, M.I.M.C.. "New LncRNAs in Chronic Hepatitis C progression: from fibrosis to hepatocellular carcinoma". Scientific Reports 10 1 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85086691090&partnerID=MN8TOARS.
    10.1038/s41598-020-66881-2
  34. Tsatskis, Y.; Rosenfeld, R.; Pearson, J.D.; Boswell, C.; Qu, Y.; Kim, K.; Fabian, L.; et al. "The NEMP family supports metazoan fertility and nuclear envelope stiffness". Science Advances 6 35 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85090872373&partnerID=MN8TOARS.
    10.1126/sciadv.abb4591
  35. Gonçalves, J.; Sharma, A.; Coyaud, É.; Laurent, E.M.N.; Raught, B.; Pelletier, L.. "LUZP1 and the tumor suppressor EPLIN modulate actin stability to restrict primary cilia formation". Journal of Cell Biology 219 7 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85086061049&partnerID=MN8TOARS.
    10.1083/JCB.201908132
  36. Goncalves, Joao. "Efficacy, immunogenicity and cost analysis of a systematic switch from originator infliximab to biosimilar CT-P13 of all patients with inflammatory arthritis from a single center.". Acta reumatologica portuguesa (2019):
  37. Goncalves, Joao. "Immunogenicity of Biosimilars for Rheumatic Diseases, Plaque Psoriasis, and Inflammatory Bowel Disease: A Review from Clinical Trials and Regulatory Documents". BioDrugs (2019): http://dx.doi.org/10.1007/s40259-019-00394-x.
    10.1007/s40259-019-00394-x
  38. Goncalves, Joao. "Biosimilars: An Opportunity to Update the Product Information of Biological Drugs Regarding their Immunogenicity.". BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy (2019): https://doi.org/10.1007/s40259-019-00391-0.
    10.1007/s40259-019-00391-0
  39. Goncalves, Joao. "Inhibition of HIV replication through siRNA carried by CXCR4-targeted chimeric nanobody.". Cellular and molecular life sciences : CMLS (2019): https://doi.org/10.1007/s00018-019-03334-8.
    10.1007/s00018-019-03334-8
  40. Goncalves, Joao. "Analysis of Immunogenicity Data in the Product Information of Biological Drugs: A Need to Report Immunogenicity Data Systematically.". BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy (2019): https://doi.org/10.1007/s40259-019-00387-w.
    10.1007/s40259-019-00387-w
  41. Goncalves, Joao. "Abstract Supplement 2019 ACR/ARP Annual Meeting". Arthritis & Rheumatology (2019): http://dx.doi.org/10.1002/art.41108.
    10.1002/art.41108
  42. Goncalves, Joao. "Biosimilars in rheumatology.". Pharmacological research (2019): https://doi.org/10.1016/j.phrs.2019.104467.
    10.1016/j.phrs.2019.104467
  43. Goncalves, Joao. "Nucleolin-based targeting strategies for cancer therapy: from targeted drug delivery to cytotoxic ligands.". Drug discovery today (2019): https://doi.org/10.1016/j.drudis.2019.06.018.
    10.1016/j.drudis.2019.06.018
  44. Goncalves, Joao. "Era of biosimilars in rheumatology: reshaping the healthcare environment.". RMD open (2019): http://europepmc.org/articles/PMC6560670.
    10.1136/rmdopen-2019-000900
  45. Goncalves, Joao. "Anti-TNF biosimilars in psoriasis: from scientific evidence to real-world experience.". The Journal of dermatological treatment (2019): https://doi.org/10.1080/09546634.2019.1610553.
    10.1080/09546634.2019.1610553
  46. Goncalves, Joao. "P664 SB5 and reference adalimumab show cross-immunogenicity in patients with inflammatory bowel disease or rheumatoid arthritis". Journal of Crohn's and Colitis (2019): http://dx.doi.org/10.1093/ecco-jcc/jjy222.788.
    10.1093/ecco-jcc/jjy222.788
  47. Goncalves, Joao. "SB5 shows cross-immunogenicity to adalimumab but not infliximab: results in patients with inflammatory bowel disease or rheumatoid arthritis". Therapeutic Advances in Gastroenterology (2019): http://dx.doi.org/10.1177/1756284819891081.
    10.1177/1756284819891081
  48. Gheiratmand, L.; Coyaud, E.; Gupta, G.D.; Laurent, E.M.N.; Hasegan, M.; Prosser, S.L.; Gonçalves, J.; Raught, B.; Pelletier, L.. "Spatial and proteomic profiling reveals centrosome-independent features of centriolar satellites". EMBO Journal 38 14 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85067074085&partnerID=MN8TOARS.
    10.15252/embj.2018101109
  49. Valido, A.; Silva-Dinis, J.; Saavedra, M.J.; Iria, I.; Gonçalves, J.; Lopes, J.P.; Fonseca, J.E.. "Efficacy, immunogenicity and cost analysis of a systematic switch from originator infliximab to biosimilar CT-P13 of all patients with inflammatory arthritis from a single center". Acta Reumatologica Portuguesa 44 4 (2019): 303-311. http://www.scopus.com/inward/record.url?eid=2-s2.0-85083623934&partnerID=MN8TOARS.
  50. Soares, H.; Carmona, B.; Nolasco, S.; Melo, L.V.; Gonçalves, J.. "Cilia distal domain: Diversity in evolutionarily conserved structures". Cells 8 2 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85128259339&partnerID=MN8TOARS.
    10.3390/cells8020160
  51. Goncalves, Joao. "Establishment of a bioluminescent canine B-cell lymphoma xenograft model for monitoring tumor progression and treatment response in preclinical studies.". PloS one (2018): http://europepmc.org/articles/PMC6310248.
    10.1371/journal.pone.0208147
  52. Goncalves J; Magro F; Danese S; Lakatos PL; Ben-Horin S. "Editorial: antigenic response to CT-P13 and infliximab originator in IBD shows similar epitope recognition-evidence from basic science supports safe switching to biosimilars. Authors' reply.". Alimentary pharmacology & therapeutics (2018): http://europepmc.org/abstract/med/30156326.
    10.1111/apt.14860
  53. Goncalves J; Santos M; Acurcio R; Iria I; Gouveia L; Matos Brito P; Catarina Cunha-Santos A; et al. "Antigenic response to CT-P13 and infliximab originator in inflammatory bowel disease patients shows similar epitope recognition.". Alimentary pharmacology & therapeutics (2018): http://europepmc.org/abstract/med/29873091.
    10.1111/apt.14808
  54. Goncalves, Joao. "FRI0663 The fine specificity of anti-drug antibody responses to originator and biosimilar infliximab: analyses across five diseases from the 52-week randomized nor-switch study". FRIDAY, 15 JUNE 2018 (2018): http://dx.doi.org/10.1136/annrheumdis-2018-eular.5554.
    10.1136/annrheumdis-2018-eular.5554
  55. Goncalves, Joao. "AB0473 Immunogenicity of biosimilars for rheumatic diseases: an updated review from regulatory documents and confirmatory clinical trials". Rheumatoid arthritis – biological DMARDs (2018): http://dx.doi.org/10.1136/annrheumdis-2018-eular.3076.
    10.1136/annrheumdis-2018-eular.3076
  56. Jacinto, M.J.; Patinha, D.J.S.; Marrucho, I.M.; Gonçalves, J.; Willson, R.C.; Azevedo, A.M.; Aires-Barros, M.R.. "M13 bacteriophage purification using poly(ionic liquids) as alternative separation matrices". Journal of Chromatography A 1532 (2018): 246-250. http://www.scopus.com/inward/record.url?eid=2-s2.0-85038622459&partnerID=MN8TOARS.
    10.1016/j.chroma.2017.12.005
  57. Romano, S.; Moura, V.; Simões, S.; Moreira, J.N.; Gonçalves, J.. "Anticancer activity and antibody-dependent cell-mediated cytotoxicity of novel anti-nucleolin antibodies". Scientific Reports 8 1 (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85046953061&partnerID=MN8TOARS.
    10.1038/s41598-018-25816-8
  58. Kay, J.; Schoels, M.M.; Dörner, T.; Emery, P.; Kvien, T.K.; Smolen, J.S.; Breedveld, F.C.; et al. "Consensus-based recommendations for the use of biosimilars to treat rheumatological diseases". Annals of the Rheumatic Diseases 77 2 (2018): 165-174. http://www.scopus.com/inward/record.url?eid=2-s2.0-85041496935&partnerID=MN8TOARS.
    10.1136/annrheumdis-2017-211937
  59. Dias, J.N.R.; Aguiar, S.I.; Pereira, D.M.; André, A.S.; Gano, L.; Correia, J.D.G.; Carrapiço, B.; et al. "The histone deacetylase inhibitor panobinostat is a potent antitumor agent in canine diffuse large B-cell lymphoma". Oncotarget 9 47 (2018): 28586-28598. http://www.scopus.com/inward/record.url?eid=2-s2.0-85048750657&partnerID=MN8TOARS.
    10.18632/oncotarget.25580
  60. Canning, P.; Park, K.; Gonçalves, J.; Li, C.; Howard, C.J.; Sharpe, T.D.; Holt, L.J.; et al. "CDKL Family Kinases Have Evolved Distinct Structural Features and Ciliary Function". Cell Reports 22 4 (2018): 885-894. http://www.scopus.com/inward/record.url?eid=2-s2.0-85044849743&partnerID=MN8TOARS.
    10.1016/j.celrep.2017.12.083
  61. Coyaud, E.; Ranadheera, C.; Cheng, D.; Gonçalves, J.; Dyakov, B.J.A.; Laurent, E.M.N.; St-Germain, J.; et al. "Global interactomics uncovers extensive organellar targeting by Zika Virus". Molecular and Cellular Proteomics 17 11 (2018): 2242-2255. http://www.scopus.com/inward/record.url?eid=2-s2.0-85055914092&partnerID=MN8TOARS.
    10.1074/mcp.TIR118.000800
  62. Goncalves, Joao. "The biosimilar approval process: how different is it?". Considerations in Medicine (2017): http://dx.doi.org/10.1136/conmed-2017-100003.
    10.1136/conmed-2017-100003
  63. Goncalves, Joao. "Biosimilars: considerations for clinical practice". Considerations in Medicine (2017): http://dx.doi.org/10.1136/conmed-2017-100005.
    10.1136/conmed-2017-100005
  64. Goncalves, Joao. "Biosimilars already approved and in development". Considerations in Medicine (2017): http://dx.doi.org/10.1136/conmed-2017-100004.
    10.1136/conmed-2017-100004
  65. Goncalves, Joao. "Considering biosimilar policy". Considerations in Medicine (2017): http://dx.doi.org/10.1136/conmed-2017-100006.
    10.1136/conmed-2017-100006
  66. Goncalves, Joao. "SAT0160 Immunogenicity of biosimilars for the treatment of inflammatory rheumatic diseases: a review from confirmatory clinical trials". Poster Presentations (2017): http://dx.doi.org/10.1136/annrheumdis-2017-eular.2486.
    10.1136/annrheumdis-2017-eular.2486
  67. Goncalves, Joao. "AB0096 Efficacy and safety of oral administration of pure celastrol in aia rats". Abstracts Accepted for Publication (2017): http://dx.doi.org/10.1136/annrheumdis-2017-eular.2868.
    10.1136/annrheumdis-2017-eular.2868
  68. Goncalves, Joao. "SAT0046 TNF antagonist drug safety assessment by pharmacovigilance signaling and post-marketing adverse event reports". Poster Presentations (2017): http://dx.doi.org/10.1136/annrheumdis-2017-eular.5884.
    10.1136/annrheumdis-2017-eular.5884
  69. Cantante, C.; Lourenço, S.; Morais, M.; Leandro, J.; Gano, L.; Silva, N.; Leandro, P.; et al. "Albumin-binding domain from Streptococcus zooepidemicus protein Zag as a novel strategy to improve the half-life of therapeutic proteins". Journal of Biotechnology 253 (2017): 23-33. http://www.scopus.com/inward/record.url?eid=2-s2.0-85019767367&partnerID=MN8TOARS.
    10.1016/j.jbiotec.2017.05.017
  70. Figueira, T.N.; Freire, J.M.; Cunha-Santos, C.; Heras, M.; Gonçalves, J.; Moscona, A.; Porotto, M.; Salomé Veiga, A.; Castanho, M.A.R.B.. "Quantitative analysis of molecular partition towards lipid membranes using surface plasmon resonance". Scientific Reports 7 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85016743213&partnerID=MN8TOARS.
    10.1038/srep45647
  71. Amaral, A.J.; Andrade, J.; Foxall, R.B.; Matoso, P.; Matos, A.M.; Soares, R.S.; Rocha, C.; et al. "miRNA profiling of human naive CD4 T cells links miR-34c-5p to cell activation and HIV replication". EMBO Journal 36 3 (2017): 346-360. http://www.scopus.com/inward/record.url?eid=2-s2.0-85007009008&partnerID=MN8TOARS.
    10.15252/embj.201694335
  72. Goncalves, J.; Matos de Brito, P.; Batista, A.; Feio, J.; Machado, F.; Aperta, J.; Ascensão, I.; et al. "Position Paper from the Portuguese Association of Hospital Pharmacists for biosimilar therapeutic antibodies". Journal of Clinical Pharmacy and Therapeutics 42 2 (2017): 239-243. http://www.scopus.com/inward/record.url?eid=2-s2.0-85003906008&partnerID=MN8TOARS.
    10.1111/jcpt.12477
  73. Gouveia, Z.; Carlos, A.R.; Yuan, X.; Aires-da-Silva, F.; Stocker, R.; Maghzal, G.J.; Leal, S.S.; et al. "Characterization of plasma labile heme in hemolytic conditions". FEBS Journal 284 19 (2017): 3278-3301. http://www.scopus.com/inward/record.url?eid=2-s2.0-85029000547&partnerID=MN8TOARS.
    10.1111/febs.14192
  74. Cavaco, M.; Goncalves, J.. "Interactions Between Therapeutic Proteins and Small Molecules: The Shared Role of Perpetrators and Victims". Clinical Pharmacology and Therapeutics 102 4 (2017): 649-661. http://www.scopus.com/inward/record.url?eid=2-s2.0-85021420005&partnerID=MN8TOARS.
    10.1002/cpt.605
  75. Santos, F.M.F.; Matos, A.I.; Ventura, A.E.; Gonçalves, J.; Veiros, L.F.; Florindo, H.F.; Gois, P.M.P.. "Modular Assembly of Reversible Multivalent Cancer-Cell-Targeting Drug Conjugates". Angewandte Chemie - International Edition 56 32 (2017): 9346-9350. http://www.scopus.com/inward/record.url?eid=2-s2.0-85022198030&partnerID=MN8TOARS.
    10.1002/anie.201703492
  76. Ferrão, J.; Silva, M.; Gonçalves, L.; Gomes, S.; Loureiro, P.; Coelho, A.; Miranda, A.; et al. "Widening the spectrum of deletions and molecular mechanisms underlying alpha-thalassemia". Annals of Hematology 96 11 (2017): 1921-1929. http://www.scopus.com/inward/record.url?eid=2-s2.0-85028970384&partnerID=MN8TOARS.
    10.1007/s00277-017-3090-y
  77. Seixas, C.; Gonçalves, J.; Melo, L.V.; Soares, H.. "Tetrahymena Cilia Cap is Built in a Multi-step Process: A Study by Atomic Force Microscopy". Protist 168 6 (2017): 697-717. http://www.scopus.com/inward/record.url?eid=2-s2.0-85034098570&partnerID=MN8TOARS.
    10.1016/j.protis.2017.10.001
  78. Araujo, F.C.; Fonseca, J.E.; Goncalves, J.. "Editorial: The Explosion of Biosimilars in Immune Mediated Chronic Inflammatory Diseases". Current pharmaceutical design 23 44 (2017): 6731-6732. http://www.scopus.com/inward/record.url?eid=2-s2.0-85066234375&partnerID=MN8TOARS.
    10.2174/138161282344180215163158
  79. Gonçalves, J.; Pelletier, L.. "The ciliary transition zone: Finding the pieces and assembling the gate". Molecules and Cells 40 4 (2017): 243-253. http://www.scopus.com/inward/record.url?eid=2-s2.0-85018429965&partnerID=MN8TOARS.
    10.14348/molcells.2017.0054
  80. Faria, R.; Silva, B.; Silva, C.; Loureiro, P.; Queiroz, A.; Fraga, S.; Esteves, J.; et al. "Next-generation sequencing of hereditary hemochromatosis-related genes: Novel likely pathogenic variants found in the Portuguese population". Blood Cells, Molecules, and Diseases 61 (2016): 10-15. http://www.scopus.com/inward/record.url?eid=2-s2.0-84979743329&partnerID=MN8TOARS.
    10.1016/j.bcmd.2016.07.004
  81. Araújo, F.; Gonçalves, J.; Fonseca, J.E.. "Biosimilar DMARDs: What Does the Future Hold?". Drugs 76 6 (2016): 629-637. http://www.scopus.com/inward/record.url?eid=2-s2.0-84960085822&partnerID=MN8TOARS.
    10.1007/s40265-016-0556-5
  82. Gonçalves, J.; Araújo, F.; Cutolo, M.; Fonseca, J.E.. "Biosimilar monoclonal antibodies: Preclinical and clinical development aspects". Clinical and Experimental Rheumatology 34 4 (2016): 698-705. http://www.scopus.com/inward/record.url?eid=2-s2.0-84984813317&partnerID=MN8TOARS.
  83. Araujo, G.R.; Fujimura, P.T.; Vaz, E.R.; Silva, T.A.; Rodovalho, V.R.; Britto-Madurro, A.G.; Madurro, J.M.; et al. "A novel reactive epitope-based antigen targeted by serum autoantibodies in oligoarticular and polyarticular juvenile idiopathic arthritis and development of an electrochemical biosensor". Immunobiology 221 5 (2016): 634-640. http://www.scopus.com/inward/record.url?eid=2-s2.0-84960490448&partnerID=MN8TOARS.
    10.1016/j.imbio.2016.01.006
  84. Cunha-Santos, C.; Figueira, T.N.; Borrego, P.; Oliveira, S.S.; Rocha, C.; Couto, A.; Cantante, C.; et al. "Development of synthetic light-chain antibodies as novel and potent HIV fusion inhibitors". AIDS 30 11 (2016): 1691-1701. http://www.scopus.com/inward/record.url?eid=2-s2.0-84964048560&partnerID=MN8TOARS.
    10.1097/QAD.0000000000001108
  85. Godinho-Santos, A.; Hance, A.J.; Goncalves, J.; Mammano, F.. "CIB1 and CIB2 are HIV-1 helper factors involved in viral entry". Scientific Reports 6 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84982806424&partnerID=MN8TOARS.
    10.1038/srep30927
  86. Perdigão, P.; Gaj, T.; Santa-Marta, M.; Barbas, C.F.; Goncalves, J.. "Reactivation of latent HIV-1 expression by engineered TALE transcription factors". PLoS ONE 11 3 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84962315127&partnerID=MN8TOARS.
    10.1371/journal.pone.0150037
  87. Cunha-Santos, C.; Figueira, T. N.; Borrego, P.; Oliveira, S. S.; Rocha, C.; Couto, A.; Cantante, C.; et al. "Development of synthetic light-chain antibodies as novel and potent HIV fusion inhibitors". Aids 30 11 (2016): 1691-1701. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000379665100004&KeyUID=WOS:000379665100004.
    10.1097/qad.0000000000001108
  88. Araújo, F.C.; Gonçalves, J.; Fonseca, J.E.. "Pharmacoeconomics of Biosimilars: What Is There to Gain from Them?". Current Rheumatology Reports 18 8 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84978033442&partnerID=MN8TOARS.
    10.1007/s11926-016-0601-0
  89. Justino, G.C.; Pinheiro, P.F.; Roseiro, A.P.S.; Knittel, A.S.O.; Gonçalves, J.; Justino, M.C.; Carvalho, M.F.N.N.. "Camphor-based CCR5 blocker lead compounds-a computational and experimental approach". RSC Advances 6 61 (2016): 56249-56259. http://www.scopus.com/inward/record.url?eid=2-s2.0-84975092092&partnerID=MN8TOARS.
    10.1039/c6ra09627a
  90. Thomas, D.; Strand, V.; Cornes, P.; Gonçalves, J.; Gulácsi, L.; Kay, J.; Kvien, T.K.; et al. "The changing landscape of biosimilars in rheumatology". Annals of the Rheumatic Diseases 75 6 (2016): 974-982. http://www.scopus.com/inward/record.url?eid=2-s2.0-84960851952&partnerID=MN8TOARS.
    10.1136/annrheumdis-2016-209166
  91. Araujo, G.R.; Vaz, E.R.; Fujimura, P.T.; Fonseca, J.E.; de Lima, L.M.; Canhão, H.; Venturini, G.; et al. "Improved serological detection of rheumatoid arthritis: A highly antigenic mimotope of carbonic anhydrase III selected in a murine model by phage display". Arthritis Research and Therapy 17 1 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84935432092&partnerID=MN8TOARS.
    10.1186/s13075-015-0685-3
  92. Araujo, G.R.; Fonseca, J.E.; Fujimura, P.T.; Cunha-Junior, J.P.; Silva, C.H.M.; Mourão, A.F.; Canhão, H.; et al. "Anti-type II collagen antibodies detection and avidity in patients with oligoarticular and polyarticular forms of juvenile idiopathic arthritis". Immunology Letters 165 1 (2015): 20-25. http://www.scopus.com/inward/record.url?eid=2-s2.0-84961292055&partnerID=MN8TOARS.
    10.1016/j.imlet.2015.03.006
  93. Seabra, C.M.; Quental, S.; Lima, A.C.; Carvalho, F.; Gonçalves, J.; Fernandes, S.; Pereira, I.; et al. "The mutational spectrum of WT1 in male infertility". Journal of Urology 193 5 (2015): 1709-1715. http://www.scopus.com/inward/record.url?eid=2-s2.0-84927913414&partnerID=MN8TOARS.
    10.1016/j.juro.2014.11.004
  94. Lima, A.C.; Carvalho, F.; Gonçalves, J.; Fernandes, S.; Marques, P.I.; Sousa, M.; Barros, A.; et al. "Rare double sex and mab-3-related transcription factor 1 regulatory variants in severe spermatogenic failure". Andrology 3 5 (2015): 825-833. http://www.scopus.com/inward/record.url?eid=2-s2.0-84942294291&partnerID=MN8TOARS.
    10.1111/andr.12063
  95. Gupta, G.D.; Coyaud, É.; Gonçalves, J.; Mojarad, B.A.; Liu, Y.; Wu, Q.; Gheiratmand, L.; et al. "A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface". Cell 163 6 (2015): 1484-1499. http://www.scopus.com/inward/record.url?eid=2-s2.0-84949216990&partnerID=MN8TOARS.
    10.1016/j.cell.2015.10.065
  96. Gonçalves, J.; Mojarad, B.; Gupta, G.; Coyaud, E.; Raught, B.; Pelletier, L.. "A systematic proximity map of the centriole-cilia interface". Cilia SUPPLEMENT (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84999810235&partnerID=MN8TOARS.
    10.1186/2046-2530-4-S1-P72
  97. Morais, M.; Cantante, C.; Gano, L.; Santos, I.; Lourenço, S.; Santos, C.; Fontes, C.; et al. "Biodistribution of a67Ga-labeled anti-TNF VHH single-domain antibody containing a bacterial albumin-binding domain (Zag)". Nuclear Medicine and Biology 41 S (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84899084462&partnerID=MN8TOARS.
    10.1016/j.nucmedbio.2014.01.009
  98. Araújo, F.; Cordeiro, I.; Teixeira, F.; Gonçalves, J.; Fonseca, J.. "Pharmacology of biosimilar candidate drugs in rheumatology: A literature review". Acta Reumatologica Portuguesa 39 1 (2014): 19-26. http://www.scopus.com/inward/record.url?eid=2-s2.0-84897519722&partnerID=MN8TOARS.
  99. Fonseca, J.E.; Gonçalves, J.; Araújo, F.; Cordeiro, I.; Teixeira, F.; Canhão, H.; José António Pereira da Silva; et al. "The portuguese society of rheumatology position paper on the use of biosimilars". Acta Reumatologica Portuguesa 39 1 (2014): 60-71. http://www.scopus.com/inward/record.url?eid=2-s2.0-84897545473&partnerID=MN8TOARS.
  100. Branco, V.; Godinho-Santos, A.; Gonçalves, J.; Lu, J.; Holmgren, A.; Carvalho, C.. "Mitochondrial thioredoxin reductase inhibition, selenium status, and Nrf-2 activation are determinant factors modulating the toxicity of mercury compounds". Free Radical Biology and Medicine 73 (2014): 95-105. http://www.scopus.com/inward/record.url?eid=2-s2.0-84902013510&partnerID=MN8TOARS.
    10.1016/j.freeradbiomed.2014.04.030
  101. Seabra, C.M.; Quental, S.; Neto, A.P.; Carvalho, F.; Gonçalves, J.; Oliveira, J.P.; Fernandes, S.; et al. "A novel Alu-mediated microdeletion at 11p13 removes WT1 in a patient with cryptorchidism and azoospermia". Reproductive BioMedicine Online 29 3 (2014): 388-391. http://www.scopus.com/inward/record.url?eid=2-s2.0-84926222251&partnerID=MN8TOARS.
    10.1016/j.rbmo.2014.04.017
  102. Silva, B.; Pita, L.; Gomes, S.; Gonçalves, J.; Faustino, P.. "The hepcidin gene promoter nc.-1010C > T; -582A > G haplotype modulates serum ferritin in individuals carrying the common H63D mutation in HFE gene". Annals of Hematology 93 12 (2014): 2063-2066. http://www.scopus.com/inward/record.url?eid=2-s2.0-84922254973&partnerID=MN8TOARS.
    10.1007/s00277-014-2160-7
  103. Cardoso, R.; Nolasco, S.; Gonçalves, J.; Cortes, H.C.; Leitão, A.; Soares, H.. "Besnoitia besnoiti and toxoplasma gondii: Two apicomplexan strategies to manipulate the host cell centrosome and golgi apparatus". Parasitology 141 11 (2014): 1436-1454. http://www.scopus.com/inward/record.url?eid=2-s2.0-84906791277&partnerID=MN8TOARS.
    10.1017/S0031182014000493
  104. Goncalves, Joao. "Mutations selected in HIV-2-infected patients failing a regimen including atazanavir". Journal of Antimicrobial Chemotherapy (2013): http://dx.doi.org/10.1093/jac/dks363.
    10.1093/jac/dks363
  105. Santa-Marta, M.; Brito, P.M.D.; Godinho-Santos, A.; Goncalves, J.. "Host factors and HIV-1 replication: Clinical evidence and potential therapeutic approaches". Frontiers in Immunology 4 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84975072486&partnerID=MN8TOARS.
    10.3389/fimmu.2013.00343
  106. Carranza, G.; Castaño, R.; Fanarraga, M.L.; Villegas, J.C.; Gonçalves, J.; Soares, H.; Avila, J.; et al. "Autoinhibition of TBCB regulates EB1-mediated microtubule dynamics". Cellular and Molecular Life Sciences 70 2 (2013): 357-371. http://www.scopus.com/inward/record.url?eid=2-s2.0-84872363321&partnerID=MN8TOARS.
    10.1007/s00018-012-1114-2
  107. Oliveira, S.S.; Da Silva, F.A.; Lourenco, S.; Freitas-Vieira, A.; Santos, A.C.C.; Goncalves, J.. "Assessing combinatorial strategies to multimerize libraries of single-domain antibodies". Biotechnology and Applied Biochemistry 59 3 (2012): 193-204. http://www.scopus.com/inward/record.url?eid=2-s2.0-84862557741&partnerID=MN8TOARS.
    10.1002/bab.1011
  108. Da Silva, F.A.; Li, M.; Rato, S.; Maia, S.; Malhõ, R.; Warren, K.; Harrich, D.; et al. "Recombinant rabbit single-chain antibodies bind to the catalytic and C-terminal domains of HIV-1 integrase protein and strongly inhibit HIV-1 replication". Biotechnology and Applied Biochemistry 59 5 (2012): 353-366. http://www.scopus.com/inward/record.url?eid=2-s2.0-84867769333&partnerID=MN8TOARS.
    10.1002/bab.1034
  109. Pimenta, J.; Domingos, A.; Santos, P.; Marques, C.C.; Cantante, C.; Santos, A.; Barbas, J.P.; et al. "Is prnt a pseudogene? identification of ram prt in testis and ejaculated spermatozoa". PLoS ONE 7 8 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84865296947&partnerID=MN8TOARS.
    10.1371/journal.pone.0042957
  110. Tavares, A.; Gonçalves, J.; Florindo, C.; Tavares, A.A.; Soares, H.. "Mob1: Defining cell polarity for proper cell division". Journal of Cell Science 125 2 (2012): 516-527. http://www.scopus.com/inward/record.url?eid=2-s2.0-84858136517&partnerID=MN8TOARS.
    10.1242/jcs.096610
  111. Nolasco, S.; Bellido, J.; Gonçalves, J.; Tavares, A.; Zabala, J.C.; Soares, H.. "The expression of tubulin cofactor A (TBCA) is regulated by a noncoding antisense Tbca RNA during testis maturation". PLoS ONE 7 8 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84864697552&partnerID=MN8TOARS.
    10.1371/journal.pone.0042536
  112. Cadima-Couto, I.; Saraiva, N.; Santos, A.C.C.; Goncalves, J.. "HIV-1 Vif interaction with APOBEC3 deaminases and its characterization by a new sensitive assay". Journal of Neuroimmune Pharmacology 6 2 (2011): 296-307. http://www.scopus.com/inward/record.url?eid=2-s2.0-79957449842&partnerID=MN8TOARS.
    10.1007/s11481-011-9258-7
  113. Esteves, A.I.S.; Nicolai, M.; Humanes, M.; Goncalves, J.. "Sulfated polysaccharides in marine sponges: Extraction methods and anti-HIV activity". Marine Drugs 9 1 (2011): 139-153. http://www.scopus.com/inward/record.url?eid=2-s2.0-79251517394&partnerID=MN8TOARS.
    10.3390/md9010139
  114. Vieira, A.; Paiva, S.; Baptista, C.; Ruas, L.; Silva, J.; Gonçalves, J.; Carrilho, F.; Carvalheiro, M.. "Late onset congenital adrenal hyperplasia due to 21-hydroxylase deficiency revision of literature and preconception genetic study of five couples,Hiperplasia congénita da suprarenal de expressão tardia por deficiência de 21-hidroxilase revisão da literatura e estudo genético preconcepção de cinco casais". Acta Medica Portuguesa 24 1 (2011): 99-110. http://www.scopus.com/inward/record.url?eid=2-s2.0-79953253929&partnerID=MN8TOARS.
  115. Sutton, E.; Hughes, J.; White, S.; Sekido, R.; Tan, J.; Arboleda, V.; Rogers, N.; et al. "Identification of SOX3 as an XX male sex reversal gene in mice and humans". Journal of Clinical Investigation 121 1 (2011): 328-341. http://www.scopus.com/inward/record.url?eid=2-s2.0-78650938438&partnerID=MN8TOARS.
    10.1172/JCI42580
  116. Rato, S.; Maia, S.; Brito, P.M.; Resende, L.; Pereira, C.F.; Moita, C.; Freitas, R.P.; et al. "Novel HIV-1 knockdown targets identified by an enriched kinases/phosphatases shRNA library using a long-term iterative screen in jurkat T-cells". PLoS ONE 5 2 (2010): http://www.scopus.com/inward/record.url?eid=2-s2.0-77949530684&partnerID=MN8TOARS.
    10.1371/journal.pone.0009276
  117. Cadima-Couto, I.; Goncalves, J.. "Towards inhibition of Vif-APOBEC3G interaction: Which protein to target?". Advances in Virology 2010 (2010): http://www.scopus.com/inward/record.url?eid=2-s2.0-84873879857&partnerID=MN8TOARS.
    10.1155/2010/649315
  118. Corte-Real, S.; Fonseca, L.; Barbas III, C.; Goncalves, J.. "Intrabody-based mapping of latency-associated nuclear antigen from Kaposi's sarcoma-associated herpesvirus show conserved epitopes for viral latency inhibition". Virology: Research and Treatment 2 (2010): 1-16. http://www.scopus.com/inward/record.url?eid=2-s2.0-77951281594&partnerID=MN8TOARS.
  119. Navarro-Costa, P.; Gonçalves, J.; Plancha, C.E.. "The AZFc region of the Y chromosome: At the crossroads between genetic diversity and male infertility". Human Reproduction Update 16 5 (2010): 525-542. http://www.scopus.com/inward/record.url?eid=2-s2.0-77955636758&partnerID=MN8TOARS.
    10.1093/humupd/dmq005
  120. Gonçalves, J.; Tavares, A.; Carvalhal, S.; Soares, H.. "Revisiting the tubulin folding pathway: New roles in centrosomes and cilia". Biomolecular Concepts 1 5-6 (2010): 423-434. http://www.scopus.com/inward/record.url?eid=2-s2.0-84893656068&partnerID=MN8TOARS.
    10.1515/bmc.2010.033
  121. Gonçalves, J.; Nolasco, S.; Nascimento, R.; Fanarraga, M.L.; Zabala, J.C.; Soares, H.. "TBCCD1, a new centrosomal protein, is required for centrosome and Golgi apparatus positioning". EMBO Reports 11 3 (2010): 194-200. http://www.scopus.com/inward/record.url?eid=2-s2.0-77649275251&partnerID=MN8TOARS.
    10.1038/embor.2010.5
  122. Cadima-Couto, I.; Freitas-Vieira, A.; Nowarski, R.; Britan-Rosich, E.; Kotler, M.; Goncalves, J.. "Ubiquitin-fusion as a strategy to modulate protein half-life: A3G antiviral activity revisited". Virology 393 2 (2009): 286-294. http://www.scopus.com/inward/record.url?eid=2-s2.0-70349832513&partnerID=MN8TOARS.
    10.1016/j.virol.2009.07.031
  123. Aires Da Silva, F.; Corte-Real, S.; Goncalves, J.. "Recombinant antibodies as therapeutic agents: Pathways for modeling new biodrugs". BioDrugs 22 5 (2008): 301-314. http://www.scopus.com/inward/record.url?eid=2-s2.0-51549091266&partnerID=MN8TOARS.
    10.2165/00063030-200822050-00003
  124. Santa-Marta, M.; Aires da Silva, F.; Fonseca, A.M.; Rato, S.; Goncalves, J.. "HIV-1 Vif protein blocks the cytidine deaminase activity of B-cell specific AID in E. coli by a similar mechanism of action". Molecular Immunology 44 4 (2007): 583-590. http://www.scopus.com/inward/record.url?eid=2-s2.0-33747840698&partnerID=MN8TOARS.
    10.1016/j.molimm.2006.02.005
  125. Encarnação, J.M.; Rosa, L.; Rodrigues, R.; Pedro, L.; da Silva, F.A.; Gonçalves, J.; Ferreira, G.N.M.. "Piezoelectric biosensors for biorecognition analysis: Application to the kinetic study of HIV-1 Vif protein binding to recombinant antibodies". Journal of Biotechnology 132 2 (2007): 142-148. http://www.scopus.com/inward/record.url?eid=2-s2.0-35349004256&partnerID=MN8TOARS.
    10.1016/j.jbiotec.2007.04.010
  126. Ferreira, G.N.M.; Encarnação, J.M.; Rosa, L.; Rodrigues, R.; Breyner, R.; Barrento, S.; Pedro, L.; Aires da Silva, F.; Gonçalves, J.. "Recombinant single-chain variable fragment and single domain antibody piezoimmunosensors for detection of HIV1 virion infectivity factor". Biosensors and Bioelectronics 23 3 (2007): 384-392. http://www.scopus.com/inward/record.url?eid=2-s2.0-34848877452&partnerID=MN8TOARS.
    10.1016/j.bios.2007.04.022
  127. Costa, M.J.L.; Pedro, L.; De Matos, A.P.A.; Aires-Barros, M.R.; Belo, J.A.; Goncalves, J.; Ferreira, G.N.M.. "Molecular construction of bionanoparticles: Chimaeric SIV p17-HIV 1 p6 nanoparticles with minimal viral protein content". Biotechnology and Applied Biochemistry 48 1 (2007): 35-43. http://www.scopus.com/inward/record.url?eid=2-s2.0-34548527272&partnerID=MN8TOARS.
    10.1042/BA20060208
  128. Eberhardy, S.R.; Goncalves, J.; Coelho, S.; Segal, D.J.; Berkhout, B.; Barbas III, C.F.. "Inhibition of human immunodeficiency virus type 1 replication with artificial transcription factors targeting the highly conserved primer-binding site". Journal of Virology 80 6 (2006): 2873-2883. http://www.scopus.com/inward/record.url?eid=2-s2.0-33644774584&partnerID=MN8TOARS.
    10.1128/JVI.80.6.2873-2883.2006
  129. Ribeiro, A.C.; Maia E Silva, A.; Santa-Marta, M.; Pombo, A.; Moniz-Pereira, J.; Goncalves, J.; Barahona, I.. "Functional analysis of Vif protein shows less restriction of human immunodeficiency virus type 2 by APOBEC3G". Journal of Virology 79 2 (2005): 823-833. http://www.scopus.com/inward/record.url?eid=2-s2.0-11144230447&partnerID=MN8TOARS.
    10.1128/JVI.79.2.823-833.2005
  130. Gonçalves, J.; Malta-Vacas, J.; Louis, M.; Brault, L.; Bagrel, D.; Monteiro, C.; Brito, M.. "Modulation of translation factor's gene expression by histone deacetylase inhibitors in breast cancer cells". Clinical Chemistry and Laboratory Medicine 43 2 (2005): 151-156. http://www.scopus.com/inward/record.url?eid=2-s2.0-14944357254&partnerID=MN8TOARS.
    10.1515/CCLM.2005.025
  131. Corte-Real, S.; Collins, C.; Aires Da Silva, F.; Simas, J.P.; Barbas III, C.F.; Chang, Y.; Moore, P.; Goncalves, J.. "Intrabodies targeting the Kaposi sarcoma-associated herpesvirus latency antigen inhibit viral persistence in lymphoma cells". Blood 106 12 (2005): 3797-3802. http://www.scopus.com/inward/record.url?eid=2-s2.0-28444475543&partnerID=MN8TOARS.
    10.1182/blood-2005-04-1627
  132. Santa-Marta, M.; Da Silva, F.A.; Fonseca, A.M.; Goncalves, J.. "HIV-1 Vif can directly inhibit apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3G-mediated cytidine deamination by using a single amino acid interaction and without protein degradation". Journal of Biological Chemistry 280 10 (2005): 8765-8775. http://www.scopus.com/inward/record.url?eid=2-s2.0-15744387175&partnerID=MN8TOARS.
    10.1074/jbc.M409309200
  133. Aires Da Silva, F.; Leite Costa, M.J.; Corte-Real, S.; Goncalves, J.. "Cell type-specific targeting with sindbis pseudotyped lentiviral vectors displaying anti-CCR5 single-chain antibodies". Human Gene Therapy 16 2 (2005): 223-234. http://www.scopus.com/inward/record.url?eid=2-s2.0-14844317327&partnerID=MN8TOARS.
    10.1089/hum.2005.16.223
  134. Pereira, L.; Gonçalves, J.; Goios, A.; Rocha, T.; Amorim, A.. "Human mtDNA haplogroups and reduced male fertility: Real association or hidden population substructuring". International Journal of Andrology 28 4 (2005): 241-247. http://www.scopus.com/inward/record.url?eid=2-s2.0-23044507572&partnerID=MN8TOARS.
    10.1111/j.1365-2605.2005.00539.x
  135. Nolasco, S.; Bellido, J.; Gonçalves, J.; Zabala, J.C.; Soares, H.. "Tubulin cofactor A gene silencing in mammalian cells induces changes in microtubule cytoskeleton, cell cycle arrest and cell death". FEBS Letters 579 17 (2005): 3515-3524. http://www.scopus.com/inward/record.url?eid=2-s2.0-21244462806&partnerID=MN8TOARS.
    10.1016/j.febslet.2005.05.022
  136. Goncalves, J.; Santa-Marta, M.. "HIV-1 Vif and APOBEC3G: Multiple roads to one goal". Retrovirology 1 (2004): http://www.scopus.com/inward/record.url?eid=2-s2.0-18144376374&partnerID=MN8TOARS.
    10.1186/1742-4690-1-28
  137. Segal, D.J.; Gonçalves, J.; Eberhardy, S.; Swan, C.H.; Torbett, B.E.; Li, X.; Barbas III, C.F.. "Attenuation of HIV-1 Replication in Primary Human Cells with a Designed Zinc Finger Transcription Factor". Journal of Biological Chemistry 279 15 (2004): 14509-14519. http://www.scopus.com/inward/record.url?eid=2-s2.0-2442536906&partnerID=MN8TOARS.
    10.1074/jbc.M400349200
  138. Goncalves, J.; Santa-Marta, M.. "HIV-1 Vif and APOBEC3G: multiple roads to one goal.". Retrovirology 1 (2004): http://www.scopus.com/inward/record.url?eid=2-s2.0-34248645132&partnerID=MN8TOARS.
  139. Da Silva, F.A.; Santa-Marta, M.; Freitas-Vieira, A.; Mascarenhas, P.; Barahona, I.; Moniz-Pereira, J.; Gabuzda, D.; Goncalves, J.. "Camelized rabbit-derived VH single-domain intrabodies against Vif strongly neutralize HIV-1 infectivity". Journal of Molecular Biology 340 3 (2004): 525-542. http://www.scopus.com/inward/record.url?eid=2-s2.0-2942724405&partnerID=MN8TOARS.
    10.1016/j.jmb.2004.04.062
  140. Mehle, A.; Goncalves, J.; Santa-Marta, M.; McPike, M.; Gabuzda, D.. "Phosphorylation of a novel SOCS-box regulates assembly of the HIV-1 Vif-Cul5 complex that promotes APOBEC3G degradation". Genes and Development 18 23 (2004): 2861-2866. http://www.scopus.com/inward/record.url?eid=2-s2.0-10044230343&partnerID=MN8TOARS.
    10.1101/gad.1249904
  141. Goncalves, Joao. "Catechols from abietic acid". Bioorganic & Medicinal Chemistry (2003): http://dx.doi.org/10.1016/s0968-0896(03)00063-4.
    10.1016/s0968-0896(03)00063-4
  142. Goncalves, J.; Silva, F.; Freitas-Vieira, A.; Santa-Marta, M.; Malhó, R.; Yang, X.; Gabuzda, D.; Barbas III, C.. "Functional neutralization of HIV-1 Vif protein by intracellular immunization inhibits reverse transcription and viral replication". Journal of Biological Chemistry 277 35 (2002): 32036-32045. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037199960&partnerID=MN8TOARS.
    10.1074/jbc.M201906200
  143. Ferrão, L.; Lopes, M.L.; Limbert, C.; Marques, B.; Boieiro, F.; Silva, M.; Marques, R.; et al. "Screening for Y chromosome sequences in patients with Turner syndrome,Pesquisa de sequências do cromossoma Y em indivíduos com síndroma de Turner.". Acta medica portuguesa 15 2 (2002): 89-100. http://www.scopus.com/inward/record.url?eid=2-s2.0-22044435511&partnerID=MN8TOARS.
  144. Faustino, P.; Barbot, J.; Gonçalves, J.; Peres, M.J.; Lavinha, J.. "The molecular basis of dominantly inherited beta-thalassemia,Base molecular de uma beta-talassémia de transmissão dominante.". Acta medica portuguesa 12 7-11 (1999): 293-296. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033154514&partnerID=MN8TOARS.
  145. Höglund, S.; Öhagen, Å.; Goncalves, J.; Panganiban, A.T.; Gabuzda, D.. "Ultrastructure of HIV-1 genomic RNA". Virology 233 2 (1997): 271-279. http://www.scopus.com/inward/record.url?eid=2-s2.0-0042990119&partnerID=MN8TOARS.
    10.1006/viro.1997.8585
  146. Yang, X.; Goncalves, J.; Gabuzda, D.. "Phosphorylation of Vif and its role in HIV-1 replication". Journal of Biological Chemistry 271 17 (1996): 10121-10129. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029874943&partnerID=MN8TOARS.
    10.1074/jbc.271.17.10121
  147. Goncalves, J.; Korin, Y.; Zack, J.; Gabuzda, D.. "Role of Vif in human immunodeficiency virus type 1 reverse transcription". Journal of Virology 70 12 (1996): 8701-8709. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029861076&partnerID=MN8TOARS.
  148. Goncalves, J.; Shi, B.; Yang, X.; Gabuzda, D.. "Biological activity of human immunodeficiency virus type 1 Vif requires membrane targeting by C-terminal basic domains". Journal of Virology 69 11 (1995): 7196-7204. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028871720&partnerID=MN8TOARS.
  149. Pissarra, F.; Carvalho, M.; Morais, C.; Fortuna, J.; Gonçalves, J.G.; João Neto, M.. "Muscular diseases in hyperthyroidism | Doenças musculares no hipertiroidismo.". Acta medica portuguesa 8 9 (1995): 501-504. http://www.scopus.com/inward/record.url?eid=2-s2.0-17144448090&partnerID=MN8TOARS.
  150. Goncalves, J.; Jallepalli, P.; Gabuzda, D.H.. "Subcellular localization of the Vif protein of human immunodeficiency virus type 1". Journal of Virology 68 2 (1994): 704-712. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027953516&partnerID=MN8TOARS.
  151. Gonçalves, I.; Gonçalves, J.; Périchon, B.; Osório-Almeida, L.; Krishnamoorthy, R.; Lavinha, J.. "A novel mosaic Bantu/Benin/Bantu ßshaplotype found in several African populations". Human Genetics 94 1 (1994): 101-103. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028284085&partnerID=MN8TOARS.
    10.1007/BF02272853
  152. Lavinha, J.; Gonçalves, J.; Faustino, P.; Romão, L.; Osório-Almeida, L.; Peres, M.J.; Picanço, I.; et al. "Importation route of the sickle cell trait into Portugal: contribution of molecular epidemiology.". Human Biology 64 6 (1992): 891-901. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026973150&partnerID=MN8TOARS.
  153. Faustino, P.; Osório-Almeida, L.; Barbot, J.; Espírito-Santo, D.; Gonçalves, J.; Romão, L.; Martins, M.C.; Marques, M.M.; Lavinha, J.. "Novel promoter and splice junction defects add to the genetic, clinical or geographic heterogeneity of ß-thalassaemia in the Portuguese population". Human Genetics 89 5 (1992): 573-576. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026767505&partnerID=MN8TOARS.
    10.1007/BF00219188
Capítulo de livro
  1. Goncalves, Joao. "Therapeutic Antibody Engineering and Selection Strategies". 2019.
    10.1007/10_2019_116
  2. Goncalves, Joao. "Insights on the Formulation of Recombinant Proteins". 2019.
    10.1007/10_2019_119
  3. Goncalves, Joao. "Preclinical and Clinical Development of Biosimilar Antibodies". 2016.
    10.1002/9781118940648.ch17
Livro
  1. Aguiar, S.; Dias, J.; Manuel, A.M.; Russo, R.; Gois, P.M.P.; da Silva, F.A.; Goncalves, J.. Chimeric Small Antibody Fragments as Strategy to Deliver Therapeutic Payloads. 2018.
    10.1016/bs.apcsb.2018.03.002
  2. Côrte-Real, S.; Aires Da Silva, F.; Gonçalves, J.. Development of Antibody Fragments for Therapeutic Applications. 2011.
    10.1002/9783527636730.ch16
Pré-impressão
  1. "Origin, Phylogeny, Variability and Epitope Conservation of SARS-CoV-2 Worldwide". 2021. http://dx.doi.org/10.20944/preprints202105.0750.v1.
    10.20944/preprints202105.0750.v1

Outros

Outra produção
  1. Transcriptome-wide off-target effects of steric-blocking oligonucleotides. 2020. Holgersen, E.M.; Gandhi, S.; Zhou, Y.; Kim, J.; Vaz, B.; Bogojeski, J.; Bugno, M.; et al. http://www.scopus.com/inward/record.url?eid=2-s2.0-85098907384&partnerID=MN8TOARS.
    10.1101/2020.09.03.281667
  2. LUZP1 and the tumour suppressor EPLIN are negative regulators of primary cilia formation. 2019. Gonçalves, J.; Coyaud, É.; Laurent, E.M.N.; Raught, B.; Pelletier, L.. http://www.scopus.com/inward/record.url?eid=2-s2.0-85095489184&partnerID=MN8TOARS.
    10.1101/736389
Atividades

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2022 - Atual COVID-19 vaccines in patients with chronic liver diseases: immunological responses and regulation by microRNAs
Coorientador
Universidade de Lisboa Faculdade de Farmácia, Portugal
2021 - Atual The impact of TCF1 in T-cell memory self-renewal and the effectiveness of armored CAR-T in solid tumors
Orientador
Universidade de Lisboa Faculdade de Farmácia, Portugal
2020 - Atual Novel Strategy to Detect and Localize Latent HIV Reservoirs
Orientador
Universidade de Lisboa Faculdade de Farmácia, Portugal
2019/01/01 - Atual Engineering cell lines capable to produce artificial libraries of fully human antibodies
Orientador
Universidade de Lisboa Faculdade de Farmácia, Portugal
2018/05/01 - Atual Optimize anti-nucleolin antibodies with potent ADCC activity
Coorientador
Universidade de Lisboa Faculdade de Farmácia, Portugal
2018/04/01 - Atual Development of a microfluidic system to assess the immunogenicity against therapeutic antibodies
Orientador
Universidade de Lisboa Faculdade de Farmácia, Portugal
2018/03/01 - Atual Cell microfluidic systems to discover antibodies by phage libraries
Orientador
Universidade de Lisboa Faculdade de Farmácia, Portugal
2018 - Atual HIV-1 Vif as a theraputic target for AIDS
Coorientador
Universidade de Lisboa Faculdade de Farmácia, Portugal
2021 - 2025 CAR (chimeric antigen receptor)-T cells secreting anti-PD-L1 antibodies: combining nucleolin-mediated checkpoint blockade and innate antitumor immunity against Triple-Negative Breast Cancer
Coorientador
Universidade de Lisboa Faculdade de Farmácia, Portugal
2021 - 2022 Development of Syn-Notch activators for CAR-T
Orientador
 Mestrado Ciencias Biofarmaceuticas (Mestrado)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2019 - 2020 Engineering biosensor cells to detect cancer biomarkers
Orientador
Universidade de Lisboa Faculdade de Farmácia, Portugal
2017 - 2020 Tumor targeting and therapeutic activity of nanobody-based platforms against breast cancer and angiogenic endothelial cells
Coorientador
Universidade de Lisboa Faculdade de Farmácia, Portugal
2015/03/01 - 2019/05/30 CellectAb as a novel process of generating therapeutic antibodies
Orientador
Universidade de Lisboa Faculdade de Farmácia, Portugal
2018 - 2019 Mammary organoids to study the functional impact of BRCA mutations
Orientador
 Mestrado Ciencias Biofarmaceuticas (Mestrado)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2017 - 2018 Engineering and optimizing pro-immunotoxins against HER2 positive cells
Orientador
 mestrado Ciencias biofarmaceuticas (Mestrado)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2017 - 2018 Development of CRISP-induced variability in antibody CDR for the discovery of fully human antibodies with therapeutic activities
Orientador
 Mestrado em Ciências Biofarmacêuticas (Doutoramento)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2016 - 2017 Eradication of HIV by zinc-finger nucleases
Orientador
 Mestrado em Ciências Biofarmacêuticas (Mestrado)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2013 - 2017 Eradication of HIV-1 infected cells by targeting nanoparticles carrying therapeutic plasmids
Orientador
Universidade de Lisboa Faculdade de Farmácia, Portugal
2015 - 2016 New concept of ADC by dimeric antibodies
Orientador
 Mestrado em Ciências Biofarmacêuticas (Mestrado)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2015 - 2016 Antibody-ZincFinger conjugates as new immunotherapy strategy
Orientador
 Mestrado em Ciências Biofarmacêuticas
Universidade de Lisboa Faculdade de Farmácia, Portugal
2012 - 2016 Engineering synthetic domain antibodies with broad and potent HIV-1 neutralization
Orientador
Universidade de Lisboa Faculdade de Farmácia, Portugal
2015 - 2015 CAR-T selection of antibodies
Orientador
 Mestrado em Ciências Biofarmacêuticas (Mestrado)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2014 - 2015 Targeting Membrane Proteins of Latently Infected CD4+ T Cells Providing a Starting Point to the Eradication of HIV-1
Orientador
 Mestrado em Ciências Biofarmacêuticas (Mestrado)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2010 - 2014 Novel HIV-1 Knockdown Targets Identified by an Enriched Kinases/Phosphatases shRNA Library Using a Long-Term Iterative Screen in Jurkat T-Cells
Orientador
Universidade de Lisboa Faculdade de Farmácia, Portugal
2009 - 2013 Innovative technologies to integrate in vitro screening and optimization of recombinant therapeutic antibodies
Orientador
Universidade de Lisboa Faculdade de Farmácia, Portugal
2009 - 2013 Engineering new strategies to improve pharmacokinetics of therapeutic proteins
Orientador
Universidade de Lisboa Faculdade de Farmácia, Portugal
2009 - 2013 Lentiviral target-specific strategy for molecular therapy
Orientador
Universidade de Lisboa Faculdade de Farmácia, Portugal
2009 - 2013 Functional aspects of new helper factors for HIV replication
Orientador
Universidade de Lisboa Faculdade de Farmácia, Portugal
2008 - 2012 Measles vírus: early infection, progression and pathogenesis in a transgenic mouse model
Orientador
Universidade de Lisboa Faculdade de Farmácia, Portugal
2010 - 2010 Specific elimination of HIV-1 infected cells using a Tat/Ver-dependent circuit
Orientador
 mestrado ciencias biofarmaceuticas (Mestrado)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2009 - 2010 Selecção de pequenos domínios de anticorpos específicos para o péptido ß-amilóide
Orientador
 mestrado ciencias biofarmaceuticas (Mestrado)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2009 - 2010 Factores de transcrição artificiais na identificação de genes celulares importantes na infecciosidade do HIV-1
Orientador
 mestrado ciencias biofarmaceuticas (Mestrado)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2005 - 2009 Development of intrabodies for neutralization of HIV-1 integrase
Orientador
Universidade de Lisboa Faculdade de Farmácia, Portugal
2005 - 2009 Functional neutralization of HIV-1 Vif protein by intracellular immunization inhibits reverse transcription and viral replication
Orientador
Universidade de Lisboa Faculdade de Farmácia, Portugal
2005 - 2009 Intrabodies targeting the Kaposi sarcoma–associated herpesvirus latency antigen inhibit viral persistence in lymphoma cells
Orientador
Universidade de Lisboa Faculdade de Farmácia, Portugal

Consultoria / Parecer

Descrição da atividade Instituição / Organização
2019 - 2022 Membro do laboratório colaborativo VectorB2B - Administração VectorB2B, Portugal

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2015 - 2022 I&D biofarmacos Doutoramento (Doutoramento) Universidade de Lisboa Faculdade de Farmácia, Portugal
2012 - 2022 I&D biofarmacos Mestrado de ciencias biofarmaceuticas (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2008 - 2022 Imunologia Ciências Farmacêuticas (Mestrado integrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2008 - 2022 Biotecnologia Farmacêutica Ciencias Farmaceuticas (Mestrado integrado) Universidade de Lisboa Faculdade de Farmácia, Portugal

Membro de comissão

Descrição da atividade
Tipo de participação 		Instituição / Organização
2021 - Atual Comissão de Avaliação de Medicamentos - Infarmed
Membro
 Infarmed Autoridade Nacional do Medicamento e Produtos de Saúde IP Centro de Documentação Técnica e Científica, Portugal
Distinções

Prémio

2015 Premio Genese
Gilead Sciences, França
2010 Premio HIV/SIDA
Direcção-Geral da Saúde, Portugal
2006 Premio HIV/SIDA
Direcção-Geral da Saúde, Portugal