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Education: I earned a PhD in Biology (Neuroscience) from Heidelberg University, Germany (Feb 2021; summa cum laude), with training in activity-dependent gene regulation, epigenetics, and memory across aging. Current position: I am a la Caixa Junior Leader Postdoctoral Fellow (2025–2028) at the University of Algarve (UAlg)/ABC ecosystem, and an Auxiliary Researcher at ABC CoLAB – Ageing Better (currently on unpaid leave). Research line: I lead a translational program on the molecular mechanisms of neurodegeneration and aging, with a strong focus on polyglutamine spinocerebellar ataxias (SCA2/SCA3), integrating gene therapy/pharmacology, AI-enabled quantitative phenotyping, and cross-species readouts to connect target engagement with patient-relevant functional outcomes. Projects: I have participated in 7 competitively funded research projects (including 2 as PI: la Caixa-funded Project and FCT exploratory), spanning Germany (DFG-funded projects) and Portugal/international consortia. Scientific outputs: I am the author of 23 peer-reviewed journal articles and 1 peer-reviewed proceeding (DOI) (with 9 first-author, 6 second-author, and 3 corresponding-author publications). Metrics (January 2026): h-index = 14 (Google Scholar); citations: 680 (Google Scholar). Conference contributions: >60 communications, including 8 invited talks (only a selection listed in the CV). Training, supervision, and teaching: I currently co-supervise 2 FCT-funded PhD candidates and have supervised/co-supervised Master’s, undergraduate, and research-internship projects, providing structured training in experimental design, reproducibility, ethics/compliance, and scientific writing. At UAlg I teach across 8 curricular units with annual loads up to 135 hours/year, and I previously taught in Heidelberg as a teaching assistant in two undergraduate laboratory/methods courses. Awards and service/outreach: My work has been recognized with the IZN/Chica & Heinz Schaller Young Investigator Neuroscience Award (2025), the Best Dissertation Award (BrainAid, 2022), and 2nd place in the Ruprecht-Karls Prize (2022), among other distinctions. I serve as Review Editor (Frontiers in Molecular Neuroscience), have reviewed >20 manuscripts for 13 journals, and act as an external evaluator for competitive calls (e.g., National Science Center, Poland; FCT PhD scholarships). I am the elected SPN Junior Committee Representative (2023–2027), contributed to major scientific events (e.g., FENS Regional Meeting 2023), and support training-oriented initiatives including the ISN Neurochemistry School in the Algarve (late 2026), alongside sustained public engagement and outreach activities.
Ler resumo completo ↓
Identificação

Identificação pessoal

Nome completo
David Vilhena Catarino Brito

Nomes de citação

  • Brito, David V.C.

Identificadores de autor

Ciência ID
7918-F771-8F47
ORCID iD
0000-0002-2726-9347

Websites

Domínios de atuação

  • Ciências Médicas e da Saúde - Medicina Básica - Neurociências

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português (Idioma materno)
Inglês Utilizador proficiente (C1) Utilizador proficiente (C2) Utilizador proficiente (C1) Utilizador proficiente (C2) Utilizador proficiente (C2)
Formação
Grau Classificação
2015/10/01 - 2021/02/19
Concluído
 Natural Sciences (Doutoramento)
Especialização em Neurosciences
Ruprecht Karls Universität Heidelberg, Alemanha
"Molecular Mechanisms of Memory Formation and Persistence in the Adult and Aged Brain" (TESE/DISSERTAÇÃO)
 Summa cum laude
2013/09/01 - 2015/09/01
Concluído
 Biologia Celular e Molecular (Mestrado integrado)
Especialização em Neurosciences
Universidade de Coimbra, Portugal
"GADD45ß : a novel long-term memory mediator" (TESE/DISSERTAÇÃO)
 19
2015/06 - 2015/06
Concluído
 Fundamentals of Widefield and Confocal Microscopy and Imaging (Curso médio)
European Molecular Biology Laboratory, Alemanha
2014/09/01 - 2014/10/01
Concluído
 Animal experimentation course - FELASA (Curso médio)
Ruprecht Karls Universität Heidelberg, Alemanha
2010/09/01 - 2013/07/31
Concluído
 Ciências Biomédicas (Licenciatura)
Universidade do Algarve, Portugal
"Dexamethasone suppression test in rodents: Test building and stress effects." (TESE/DISSERTAÇÃO)
 16
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2025/12/02 - Atual Investigador (Investigação) Universidade do Algarve, Portugal
2025/02/10 - Atual Investigador Auxiliar (carreira) (Investigação) Laboratório Colaborativo do Algarve Biomedical Center Soluções Integradas para o Envelhecimento e Rejuvenescimento, Portugal
2021/08/01 - 2025/02/17 Pós-doutorado (Investigação) Universidade do Algarve, Portugal
Algarve Biomedical Center Research Institute (ABC-RI), Portugal
2021/03/31 - 2021/07/31 Pós-doutorado (Investigação) Ruprecht Karls Universität Heidelberg, Alemanha
2020/10/01 - 2021/02/28 Investigador (Investigação) Ruprecht Karls Universität Heidelberg, Alemanha
2015/09/01 - 2020/09/30 Investigador Contratado (Investigação) Ruprecht Karls Universität Heidelberg, Alemanha
2014/09/01 - 2015/08/31 Investigador (Investigação) Ruprecht Karls Universität Heidelberg, Alemanha

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2024/11/01 - Atual Professor Auxiliar Convidado (Docente Universitário) Universidade do Algarve, Portugal
2023/11/01 - 2024/10/31 Assistente Convidado (Docente Universitário) Universidade do Algarve, Portugal
Projetos

Bolsa

Designação Financiadores
2025/12 - 2028/11 Glutamate-mediated neurotoxicity as a driver of disease progression in Polyglutamine Spinocerebellar Ataxias
LCF/BQ/PR25/12110005
Investigador responsável
Fundación Bancaria Caixa d'Estalvis i Pensions de Barcelona 'la Caixa', Portugal
Em curso
2026/02 - 2028/08 Glutamate-mediated neurotoxicity as a driver of disease progression in spinocerebellar ataxia type 2
2024.15133.PEX
Investigador responsável
Laboratório Colaborativo do Algarve Biomedical Center Soluções Integradas para o Envelhecimento e Rejuvenescimento, Portugal
Em curso
2023/03 - 2025/01 AdvGT-CSB – Advancing the development of a gene therapy for Cockayne Syndrome B
NA
Investigador Pós-doutorado
Em curso
2023/01 - 2025/01 CureCSB – Development of a Gene-Replacement Therapy for Cockayne Syndrome B
NA
Investigador Pós-doutorado
2022/01/01 - 2023/12/31 ALgarve Fit Ageing Score: a new integrative tool for quality of life improvement and healthy ageing - ALFA Score
ALG-45-2020-41
Bolseiro de Pós-Doutoramento
Fundação para a Ciência e a Tecnologia
Concluído
2020/08/01 - 2021/02/28 Biphasic expression of plasticity genes in the stabilization of hippocampal and neocortical fear memory neuronal ensembles
OL 437/2
Bolseiro de Pós-Doutoramento
Ruprecht Karls Universität Heidelberg, Alemanha
 Deutsche Forschungsgemeinschaft
Concluído
2020/10/01 - 2020/12/31 Molecular Mechanisms of Memory Formation and Persistence in the Adult and Aged Brain
Landesgraduiertenförderung (LGF) completion grant
Bolseiro de Doutoramento
Ruprecht Karls Universität Heidelberg, Alemanha
 Graduate Academy
Concluído
2014/09/01 - 2020/09/30 Analysis of the distinct regulatory functions of DNA methylation in memory-related gene expression
OL 437/1
Investigador
Ruprecht Karls Universität Heidelberg, Alemanha
 Deutsche Forschungsgemeinschaft
Concluído

Projeto

Designação Financiadores
2025/01/01 - 2029/12/31 Algarve Biomedical Center Research Institute
UID/06210/2025
10.54499/UID/06210/2025
Universidade do Algarve, Portugal

Algarve Biomedical Center Research Institute, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2025/02 - 2025/11 Hiring of highly qualified human resources (RHAQs)
NA
Investigador Pós-doutorado
Em curso
Produções

Publicações

Artigo em revista
  1. Moreira-Gomes, Tiago; Marcelo, Adriana; Rajado, Ana Teresa; Costa, Rafael G.; Afonso-Reis, Ricardo; Madeira, Cristiana R.; Afonso, Inês T.; et al. "Modulation of the Stress Granule Component Carhsp1 Mitigates Disease-Associated Deficits in Spinocerebellar Ataxia Type 3 Mouse Models". Movement Disorders (2026): https://doi.org/10.1002/mds.70271.
    Publicado • 10.1002/mds.70271
  2. Moreira-Gomes, Tiago; Afonso, Inês T.; Costa, Rafael G.; Brito, David V. C.; Ricardo, Pedro Alexandre; Nóbrega, Clévio. "Lentiviral-induced Striatal Pathology as a Preclinical Model of Polyglutamine Spinocerebellar Ataxias". Journal of Visualized Experiments 229 (2026): https://doi.org/10.3791/69550.
    Publicado • 10.3791/69550
  3. Nóbrega, Clévio; Marcelo, Adriana; Rajado, Ana Teresa; Conceição, André; Estevam, Bernardo; Matos, Carlos A.; Brito, David VC; et al. "Molecular hallmarks of neurodegeneration in polyglutamine spinocerebellar ataxias". Cell Death & Disease 16 1 (2025): https://doi.org/10.1038/s41419-025-08154-2.
    10.1038/s41419-025-08154-2
  4. Brito, David V.C.; Afonso, Inês T.; Nóbrega, Clévio David Rodrigues . Autor correspondente: Brito, David V.C.. "How to find the papers you need to read — and avoid the ones you don’t". Nature (2025): https://www.nature.com/articles/d41586-025-02867-2.
    Publicado
  5. Afonso-Reis, Ricardo; Madeira, Cristiana R.; Brito, David V.C.; Nóbrega, Clévio. "Insights Into Cockayne Syndrome Type B: What Underlies Its Pathogenesis?". Aging Cell (2025): https://doi.org/10.1111/acel.70136.
    Acesso aberto • Publicado • 10.1111/acel.70136
  6. Brito, D.V.C.; Nóbrega, C.; Brito, David VC; Nóbrega, Clévio. "Making bridges between preclinical and clinical insights into age-related cognitive decline". Neural Regeneration Research 20 8 (2025): 2321-2322. http://www.scopus.com/inward/record.url?eid=2-s2.0-85219572773&partnerID=MN8TOARS.
    10.4103/NRR.NRR-D-24-00200
  7. Esteves, Filipa; Brito, David V.C.; Rajado, Ana Teresa; Silva, Nádia; Apolónio, Joana; Roberto, Vânia Palma; Andrade, Raquel P.; et al. "Establishment of an induced pluripotent cell line (ABCRIi001-A) from an elderly female for ageing research". Stem Cell Research 81 (2024): 103576. https://doi.org/10.1016/j.scr.2024.103576.
    10.1016/j.scr.2024.103576
  8. Santos, Daniela F.; Sónia Simão; Raquel P Andrade; Sofia Melo Calado; Gil Carraco; Joana Apolónio; Ana Teresa Rajado; et al. Autor correspondente: Inês M Araújo. "Oxidative stress and aging: synergies for age related diseases". FEBS Letters (2024): https://febs.onlinelibrary.wiley.com/doi/10.1002/1873-3468.14995.
    Acesso aberto • Publicado • 10.1002/1873-3468.14995
  9. Brito, David V.C.; Kupke, Janina; Sokolov, Rostilav; Cambridge, Sidney; Both, Martin; Bengtson, C. Peter; Rozov, Andrei; Oliveira, Ana M. M.. "Biphasic Npas4 expression promotes inhibitory plasticity and suppression of fear memory consolidation in mice". Molecular Psychiatry 29 7 (2024): 1929-1940. https://doi.org/10.1038/s41380-024-02454-3.
    10.1038/s41380-024-02454-3
  10. David Vilhena Catarino Brito; F. Esteves; A. T. Rajado; N. Silva; R. Andrade; J. Apolónio; S. Calado; et al. "Assessing cognitive decline in the aging brain: lessons from rodent and human studies". npj Aging 9 1 (2023): http://dx.doi.org/10.1038/s41514-023-00120-6.
    Publicado • 10.1038/s41514-023-00120-6
  11. Esteves, Filipa; Brito, David V.C.; Rajado, Ana Teresa; Silva, Nádia; Apolónio, Joana; Roberto, Vânia Palma; Araújo, Inês; et al. "Reprogramming iPSCs to study age-related diseases: Models, therapeutics, and clinical trials". Mechanisms of Ageing and Development 214 (2023): 111854. http://dx.doi.org/10.1016/j.mad.2023.111854.
    10.1016/j.mad.2023.111854
  12. Nádia Silva; Ana Teresa Rajado; Filipa Esteves; Brito, David V.C.; Joana Apolónio; Vânia Palma Roberto; Alexandra Binnie; et al. Autor correspondente: Pedro Castelo-Branco. "Measuring healthy ageing: current and future tools.". Biogerontology (2023): https://link.springer.com/article/10.1007/s10522-023-10041-2.
    Acesso aberto • Publicado • 10.1007/s10522-023-10041-2
  13. Koppenol, Rebekah; Conceição, André; Afonso, Inês T; Afonso-Reis, Ricardo; Costa, Rafael G; Tomé, Sandra; Teixeira, Diogo; et al. "The stress granule protein G3BP1 alleviates spinocerebellar ataxia-associated deficits". Brain (2023): http://dx.doi.org/10.1093/brain/awac473.
    10.1093/brain/awac473
  14. Rajado, Ana Teresa; Nádia Silva; Filipa Esteves; Brito, David; Alexandra Binnie; Inês M. Araújo; Clévio Nóbrega; et al. Autor correspondente: Pedro Castelo-Branco. "How can we modulate aging through nutrition and physical exercise? An epigenetic approach". Aging (2023): https://www.aging-us.com/article/204668/text.
    Acesso aberto • Publicado • 10.18632/aging.204668
  15. Gülmez Karaca, Kübra; Brito, David V.C.; Nicolas, Céline. "Young researchers series #6". Trends in Cell Biology 33 2 (2023): 87-91. http://dx.doi.org/10.1016/j.tcb.2022.11.005.
    10.1016/j.tcb.2022.11.005
  16. Brito, David V.C.; Kupke, Janina; Gulmez Karaca, Kubra; Oliveira, Ana M.M.. "Regulation of neuronal plasticity by the DNA repair associated Gadd45 proteins". Current Research in Neurobiology 3 (2022): 100031. http://dx.doi.org/10.1016/j.crneur.2022.100031.
    Acesso aberto • Publicado • 10.1016/j.crneur.2022.100031
  17. Marcelo, Adriana; Afonso, Inês T.; Afonso-Reis, Ricardo; Brito, David V. C.; Costa, Rafael G.; Rosa, Ana; Alves-Cruzeiro, João; et al. Autor correspondente: Nóbrega, Clévio. "Autophagy in Spinocerebellar ataxia type 2, a dysregulated pathway, and a target for therapy". Cell Death & Disease 12 12 (2021): http://dx.doi.org/10.1038/s41419-021-04404-1.
    Acesso aberto • Publicado • 10.1038/s41419-021-04404-1
  18. Gulmez Karaca, Kubra; Brito, David V.C.; Kupke, Janina; Zeuch, Benjamin; Oliveira, Ana M.M.; Mudlaff, Franziska; Gomes, Rui; Lopes, Luísa V.. "Engram reactivation during memory retrieval predicts long-term memory performance in aged mice". Neurobiology of Aging 101 (2021): 256-261. http://dx.doi.org/10.1016/j.neurobiolaging.2021.01.019.
    Publicado • 10.1016/j.neurobiolaging.2021.01.019
  19. Brito, David; Karaca, Kubra Gulmez; Kupke, Janina; Frank, Lukas; Oliveira, Ana M.M.. "MeCP2 gates spatial learning-induced alternative splicing events in the mouse hippocampus". Molecular Brain 13 1 (2020): http://dx.doi.org/10.1186/s13041-020-00695-1.
    Acesso aberto • Publicado • 10.1186/s13041-020-00695-1
  20. Brito, David V.C.; Gulmez Karaca, Kubra; Kupke, Janina; Mudlaff, Franziska; Zeuch, Benjamin; Gomes, Rui; Lopes, Luísa V.; Oliveira, Ana M.M.. "Modeling human age-associated increase in Gadd45¿ expression leads to spatial recognition memory impairments in young adult mice". Neurobiology of Aging 94 (2020): 281-286. https://doi.org/10.1016/j.neurobiolaging.2020.06.021.
    10.1016/j.neurobiolaging.2020.06.021
  21. Gulmez Karaca, Kubra; Kupke, Janina; Brito, David V. C.; Zeuch, Benjamin; Thome, Christian; Weichenhan, Dieter; Lutsik, Pavlo; Plass, Christoph; Oliveira, Ana M. M.. Autor correspondente: Oliveira, Ana M. M.. "Neuronal ensemble-specific DNA methylation strengthens engram stability". Nature Communications 11 1 (2020): http://dx.doi.org/10.1038/s41467-020-14498-4.
    Publicado • 10.1038/s41467-020-14498-4
  22. Brito, David V.C.; Kupke, Janina; Gulmez Karaca, Kubra; Zeuch, Benjamin; Oliveira, Ana M.M.. "Mimicking Age-Associated Gadd45¿ Dysregulation Results in Memory Impairments in Young Adult Mice". The Journal of Neuroscience 40 6 (2019): 1197-1210. https://doi.org/10.1523/jneurosci.1621-19.2019.
    10.1523/jneurosci.1621-19.2019
  23. Karaca, Kubra Gulmez; Brito, David; Oliveira, Ana M.M. . Autor correspondente: Oliveira, Ana M.M.. "MeCP2: A Critical Regulator of Chromatin in Neurodevelopment and Adult Brain Function". International Journal of Molecular Sciences (2019): http://dx.doi.org/10.3390/ijms20184577.
    Publicado • 10.3390/ijms20184577
  24. Brito, David V.C.; Gulmez Karaca, Kubra. Autor correspondente: Brito, David V.C.. "Neuronal Chromatin Architecture Regulator CTCF Dictates Remote Memory". The Journal of Neuroscience 38 48 (2018): 10239-10240. https://doi.org/10.1523/jneurosci.1869-18.2018.
    10.1523/jneurosci.1869-18.2018
  25. Gulmez Karaca K; Brito DVC; Zeuch B; Oliveira, Ana M.M. . Autor correspondente: Oliveira, Ana M.M.. "Adult hippocampal MeCP2 preserves the genomic responsiveness to learning required for long-term memory formation.". Neurobiology of learning and memory (2018):
    Publicado • 10.1016/j.nlm.2018.02.010
Poster em conferência
  1. Rajado, Ana Teresa; Estevam, Bernardo; Costa, Rafael G; Vásquez-Mojena, Yaimée; Zamora Fung, Rolando ; Pupo Marrero, Claudia ; Jaime López, Leydis ; et al. "From Code to Chromatin: Using AI and Epigenetics to Identify SCA2 Biomarkers". Trabalho apresentado em 5th Workshop on Neuroengineering: AI tools in Neuroscience, 2025.
  2. Tiago Moreira-Gomes; Brito, David V.C.; Afonso-Reis, Ricardo; Codêsso, José Miguel; Sofia M. Calado; Aaron Voigt; Nóbrega, Clévio David Rodrigues. "Depletion of Trmt2a alleviates pathological features in an MJD/SCA3 mouse model.". Trabalho apresentado em MJD International Research Conference, 2025.
  3. Moreira-Gomes, Tiago; Marcelo, Adriana; Cristiana R. Madeira; Rajado, Ana Teresa; Afonso, Inês T.; Costa, Rafael G; Afonso-Reis, Ricardo; et al. "Investigating the therapeutic potential of Calcium-Regulated Heat Stable Protein 1, a stress granules component, in Spinocerebellar Ataxia Type 3". Trabalho apresentado em XIX Meeting of the Portuguese Society for Neuroscience, 2025.
  4. Conceição, André; Filipa Couto; Brito, David V.C.; Koppenol, Rebekah; Nóbrega, Clévio David Rodrigues. "From Stress Response to Disease Mechanism: Exploring Stress Granules in Spinocerebellar Ataxia Type 2". Trabalho apresentado em Federation of European Neuroscience Societies Meenting Viena, 2024.
  5. Brito, David V.C.; Afonso, Inês T.; Sofia M. Calado; Yand, Jin; Bading, H.; Nóbrega, Clévio David Rodrigues. "NMDAR-TRPM4 coupling drives neurotoxicity and disease progression in models of Spinocerebellar Ataxias". Trabalho apresentado em FENS, 2024.
    10.1002/1878-0261.13682
  6. Moreira-Gomes, Tiago; Brito, David V.C.; Afonso-Reis, Ricardo; Codêsso, José Miguel; Voigt, Aaron; Nóbrega, Clévio David Rodrigues. "Mitigation of polyQ-induced toxicity through depletion of Trmt2a in a MJD/SCA3 mouse model". Trabalho apresentado em Federation of European Neuroscience Societies (FENS) Forum 2024, 2024.
  7. Moreira-Gomes, Tiago; Brito, David V.C.; Afonso-Reis, Ricardo; Codêsso, José Miguel; Voigt, Aaron; Nóbrega, Clévio David Rodrigues. "Absence of RNA chaperone improves motor function and mitigates neuronal cell death in spinocerebellar ataxia type 3". Trabalho apresentado em Gordon Conference on Cell Death (Harnessing Cell Death Mechanisms in Health and Disease), 2024.
  8. Afonso, Inês T.; Brito, David V.C.; Hilmar Bading; Nóbrega, Clévio David Rodrigues. "Activity-induced genes expression is impaired in polyglutamine spinocerebellar ataxias". Trabalho apresentado em 27th SPGH Annual Meeting, 2023.
  9. Santos, Daniela F.; Simão, Sónia; Silva, Nádia; Brito, David V.C.; Clévio Nobrega; Bragança, José; Pedro Castelo-Branco; Araújo, Inês Maria. "Redox profiling of a cohort of young versus medically assisted aged individuals in the Algarve region.". Trabalho apresentado em 1st FEBS Redox Medicine Workshop: from cellular signaling to systems physiology and therapeutic targets, 2023.
  10. Moreira-Gomes, Tiago; Brito, David V.C.; Afonso-Reis, Ricardo; Codêsso, José Miguel; Voigt, Aaron; Nóbrega, Clévio David Rodrigues. "Translational regulation: exploring the impact of TRMT2A in Spinocerebellar ataxia type 3 /Machado-Joseph Disease". Trabalho apresentado em 9th European Neuroscience Conference by Doctoral Students (ENCODS), 2023.
  11. Moreira-Gomes, Tiago; Brito, David V.C.; Afonso-Reis, Ricardo; Codêsso, José Miguel; Voigt, Aaron; Nóbrega, Clévio David Rodrigues. "Silencing Trmt2a as a novel therapeutic target in Spinocerebellar ataxia type 3 /Machado-Joseph Disease". Trabalho apresentado em Federation of European Neuroscience Societies (FENS) Regional Meeting 2023 (FRM 2023), 2023.
  12. Rajado, Ana Teresa; Pestana, Daniel; Silva, Nádia; Apolónio, Joana ; Esteves, Filipa; Brito, David V.C.; Trindade, Marlene; et al. "Algarve fit ageing score project, a multidisciplinary approach to assess healthy ageing status.". Trabalho apresentado em EMBO Workshop "Systems biology: Linking chromatin and epigenetics to disease and development, 2023.
  13. Codêsso, José Miguel; Brito, David V.C.; Mendonça, Liliana; Pereira de Almeida, Luis ; Nóbrega, Clévio David Rodrigues. "Unraveling the role of the RBP HSPA8 in Spinocerebellar Ataxia type 3: from pathogenesis to therapeutics". Trabalho apresentado em Federation of European Neuroscience Societies (FENS) Regional Meeting 2023 (FRM 2023), 2023.
  14. Rajado, Ana Teresa; Raquel P. Andrade; Apolónio, Joana ; Inês Maria Pombinho de Araújo; Brito, David V.C.; Sofia M. Calado; Esteves, Filipa; et al. "ALFA Score - Algarve Fit Ageing Score". Trabalho apresentado em ABC-Days, 2022.
  15. Marcelo, Adriana; Afonso, Inês T.; Afonso-Reis, Ricardo; Brito, David V.C.; Costa, Rafael G; Ana Rosa; Alves-Cruzeiro, João; et al. "From molecular mechanisms to therapy: a new lentiviral mouse model for Spinocerebellar ataxia type 2". Trabalho apresentado em XVII Meeting of Portuguese Society for Neuroscience (SPN 2021), 2021.
  16. Brito, David V.C.; Afonso, I; Matos, Carlos A; Hilmar Bading; Nóbrega, Clévio David Rodrigues ; Carlos A Matos. "Targeting the NMDAR/TRPM4 complex as a novel therapeutic strategy for polyglutamine spinocerebellar ataxias type 3 and 2". Trabalho apresentado em IV JORNADAS Algarve Biomedical Center, 2021.
  17. Brito, David V.C.; Kupke, Janina; Gulmez Karaca K; Zeuch, Benjamin; R. Gomes; Luisa Lopes; Oliveira, Ana M.M.. "Tight regulation of Gadd45G expression across the lifespan as a requirement for cognitive function". Trabalho apresentado em IZN Retreat-“Genetics of neurological diseases: From mutations to personalized medicine”, 2019.
  18. Brito, David V.C.; Kupke, Janina; Gulmez Karaca K; R. Gomes ; Lopes, Luisa; Zeuch, Benjamin; Oliveira, Ana M.M. ; et al. Autor correspondente: Oliveira, Ana M.M.. "Mimicking age-associated Gadd45g decline results in memory impairments in young mice". Trabalho apresentado em Molecular and Cellular Cognition Society Meeting (San Diego, USA), 2018.
    10.1523/jneurosci.1621-19.2019
  19. Brito, David V.C.; Karaca, Kubra Gulmez; Zeuch, Benjamin; Oliveira, Ana M.M. . Autor correspondente: Oliveira, Ana M.M.. "Age-associated Gadd45B decrease impairs plasticity gene induction and long-term memory formation". Trabalho apresentado em IZN Retreat-CONNECTOMICS (Germany), 2016.
  20. Brito, David V.C.; Gulmez Karaca K; Zeuch, Benjamin; Oliveira, Ana M.M.. "GADD45ß KNOCKDOWN IMPAIRS PLASTICITY-ASSOCIATED GENE EXPRESSION AND LONG-TERM MEMORY FORMATION". Trabalho apresentado em IZN Retreat-Translational Neuroscience: From Cell Biology to Therapeutics, 2015.
Pré-impressão
  1. Brito, David V.C.; Pereira, Adriana Arrulo; de Souza Araujo, Renata Sandres; Várzea, Bruno André Martins; Anastácio, Xavier Guerreiro; Castro, Telma Cristina Aureliano; Aveleira, Célia; et al. "Hypothalamic CYP46A1 cholesterol metabolism regulates diet-induced obesity". 2026. https://doi.org/10.64898/2026.01.10.698773.
    10.64898/2026.01.10.698773
Tese / Dissertação
  1. Brito, David V.C.. "Molecular Mechanisms of Memory Formation and Persistence in the Adult and Aged Brain". Doutoramento, Ruprecht Karls Universität Heidelberg, 2021.
  2. Brito, David Vilhena Catarino. "GADD45ß : a novel long-term memory mediator". Mestrado, Universidade de Coimbra, 2015. http://hdl.handle.net/10316/30745.
  3. Brito, David V.C.. "Dexamethasone suppression test in rodents: Test building and stress effects.". Licenciatura, Universidade do Algarve, 2012.

Propriedade Intelectual

Pedido provisório de patente
  1. 2026. "Modulation of CYP46A1 in the hypothalamus for the treatment of obesity and associated metabolic dysfunctions.".
    Protegido
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2024/11/01 NMDAR-TRPM4 coupling drives neurotoxicity and disease progression in models of Spinocerebellar Ataxias International Congress for Ataxia Research
(Reino Unido)
2024/10/05 NMDAR-TRPM4 coupling drives neurotoxicity and disease progression in models of Spinocerebellar Ataxias IZN seminar series
(Alemanha)
2022/01/12 We are What we Remember: Molecular Insights into Memory Formation in the Adult and Aged brain National Postdoc Exchange Program
Instituto Gulbenkian de Ciência
2021/10/27 We are What we Remember: Molecular Insights into Memory Formation in the Adult and Aged brain Algarve Biomedical Center - Seminars
Algarve Biomedical Center - University of Algarve
2020/12/14 Tips & Tricks for Scientific Growth during your PhD Biomedical Sciences PhD Program Annual Journey
Biomedical Sciences PhD Program (Faro, Portugal)
2020/06/03 We are what we remember: Molecular insights into age-related cognitive decline IZN seminar series
Interdisciplinary Center for Neurosciences (IZN) (Heidelberg, Alemanha)

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2026/02 - Atual Impact of stress granule modulation on Purkinje cell morphology in a murine model of spinocerebellar ataxia type 2
Orientador
 Masters in Medicine
Universidade do Algarve, Portugal
2026/01 - Atual The gut-brain axis in Parkinson's disease: The role of dysbiosis and mitochondrial dysfunction in Parkinson's disease.
Coorientador
 Biomédical Sciences (Licenciatura/Bacharelato)
Universidade do Algarve, Portugal
2026/01 - Atual Description of the natural history of a rodent model of Cockayne syndrome: neuropathological and motor alterations.
Coorientador
 Masters in Medicine (Mestrado)
Universidade do Algarve, Portugal
2025 - Atual Dysrupted gene expression in polyglutamine spinocerebellar ataxias
Orientador
 Master in Biomedical Sciences (Mestrado)
Universidade do Algarve, Portugal
2024/10/01 - Atual Developing new tools to evaluate disease progression and outcomes in spinocerebellar ataxias: correlating mice and human studies
Coorientador
 PhD in Biomedical Sciences (Doutoramento) (Doutoramento)
2021/04/01 - Atual Expression of Activity-regulated Inhibitor of Death (AID) genes as a therapeutic strategy for Machado-Joseph disease
Coorientador
 PhD in Biomedical Sciences (Doutoramento)
Universidade do Algarve, Portugal
2025/07/07 - 2025/07/31 Summer internship
Orientador
 BSc Biomedical Sciences (Outra)
Universidade do Algarve, Portugal

Universidade de Aveiro, Portugal
2025 - 2025 Molecular mechanisms underlying therapeutics effects of NMDAR/TRPM4 interface inhibitors in spinocerebellar ataxias
Coorientador
 BSc in Biomedical Sciences (Licenciatura/Bacharelato)
2021 - 2022 Neuroprotection by Inhibition of a Death Complex in Spinocerebellar Ataxias
Coorientador
 BSc in Biomedical Sciences (Licenciatura/Bacharelato)
2019/09/16 - 2019/12/20 Methods in molecular and cell biology and surgery in rodents
Coorientador
 Biosciences (Mestrado)
Ruprecht Karls Universität Heidelberg, Alemanha
2019/04/23 - 2019/07/15 Npas4 biphasic expression in memory persistence
Coorientador
 Biosciences (Mestrado)
Ruprecht Karls Universität Heidelberg, Alemanha
2019/01/14 - 2019/03/20 Establishment of a temporally-controlled expression system
Coorientador
 Biosciences (Mestrado)
Ruprecht Karls Universität Heidelberg, Alemanha

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação) 		Instituição / Organização
2022/02/01 - Atual FENS Regional Meeting 2023 (2022/02/01)
2016/01/01 - Atual Collaborator for the Deutsche Neurowissenschaften-Olympiade (DNO)- International organization that promotes every year regional competitions in Germany for high school students to learn Neuroscience. The finalists go on to compete in a Germany-wide competition and later travel to international locations to participate in workshops. The winner receives a prize at the FENS or SfN conference (event occurs once a year). (2016/05/12)
Concurso (Membro da Comissão Organizadora)
2025/05/18 - 2025/05/21 Chair of selected Polyglutamine SCA Symposium in ESN meeting - Naxos, Greece (2024/05/20) European Society for Neurochemistry (ESN), Reino Unido
2022/03 - 2023/11 Member of the organizing committee for ESN-ISN Advanced School for Neurochemistry. (2023/11 - 2023/11)

Participação em evento

Descrição da atividade
Tipo de evento 		Nome do evento
Instituição / Organização
2019/05/22 - 2019/05/22 Participation in the a Native Scientist event. I prepared a workshop presentation for children and teenagers of parents that speak Portuguese (e.g. Portugal, Brazil) in Germany. These children are bilingual and this program encourages to stimulate further learning of their parent’s mother tongue while motivating scientific interest.
Oficina (workshop)
 Native Scientist outreach activity
2015/09/17 - 2015/09/17 Invited talk: "Bachelor in Biomedical Sciences what to expect?"
Simpósio
 Opening of the Academic year session
Universidade do Algarve, Portugal

Arbitragem científica em revista

Nome da revista (ISSN) Editora
2025/01/01 - Atual Scientific Reports
2025 - Atual Communications Biology
2025 - Atual BMC Biology
2025 - Atual Frontiers in Molecular Neuroscience
2025 - Atual Molecular Medicine
2025 - Atual Nature Genetics
2025 - Atual eLife
2024/11/01 - Atual Cellular and Molecular Life Sciences
2024/05/01 - Atual Brain
2024 - Atual Cellular and Molecular Life Sciences
2023/02/08 - Atual Journal of Neurochemistry
2022/10/30 - Atual Frontiers in Medicine (2296-858X) Frontiers
2022/06/08 - Atual Biomedicine & Pharmacotherapy
2022/04/04 - Atual Molecular Neurobiology (1559-1182) Springer Nature

Comissão de avaliação

Descrição da atividade
Tipo de assessoria 		Instituição / Organização Entidade financiadora
2025/07 - Atual External evaluator for competitive funding: FCT PhD Scholarships Call 2025 (non-academic line).
2024 - Atual External evaluator for competitive funding: National Science Center (Poland; OPUS-26/27; PRELUDIUM-23)
2023 - Atual Jury member and evaluator for institutional awards/fellowships and recruitment processes (including CureCSB Scientific Prize; research fellowship panels)

Consultoria / Parecer

Descrição da atividade Instituição / Organização
2023 - Atual Review Editor, Frontiers in Molecular Neuroscience

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2025/02/01 - Atual FELASA animal course - Instructor First Animal experimental course at ABC-RI
2024 - Atual Applied Histology BSc Biomedical Sciences Universidade do Algarve, Portugal
2023/05 - Atual Rodent stereotaxic surgeries - ISN Advanced School for Neurochemistry (Doutoramento)
2023 - Atual Animal Cell Culture Technology BSc Biomedical Sciences Universidade do Algarve - Campus de Gambelas, Portugal
2023 - Atual Animal Cell Biotechnology BSc Biochemistry and BSc Biotechnology Universidade do Algarve, Portugal
2023 - Atual Histology BSc Biomedical Sciences Universidade do Algarve, Portugal
2024 - 2025 Gene and Cell Therapy Bsc Biomedical Sciences Universidade do Algarve, Portugal
2023 - 2023 Basic and Clinical Sciences Integrated Master in Medicine Universidade do Algarve, Portugal
2020/07/20 - 2020/07/24 Teaching Assistant- Introduction to Methods in Learning and Memory Research Biosciences (Bachelor) Ruprecht Karls Universität Heidelberg, Alemanha
2020/06/15 - 2020/07/03 Teaching Assistant- Methods in Molecular Biology/Nuclear Acid Biosciences (Bachelor) Ruprecht Karls Universität Heidelberg, Alemanha
2019/06/24 - 2019/07/11 Teaching Assistant- Methods in Molecular Biology/Nuclear Acid Biosciences (Bachelor) Ruprecht Karls Universität Heidelberg, Alemanha
2019/05/13 - 2019/05/17 Teaching Assistant- Introduction to Methods in Learning and Memory Research Biosciences (Bachelor) Ruprecht Karls Universität Heidelberg, Alemanha
2017/06/19 - 2017/07/07 Teaching Assistant- Methods in Molecular Biology/Nuclear Acid Biosciences (Bachelor) Ruprecht Karls Universität Heidelberg, Alemanha
2017/01/02 - 2017/01/06 Teaching Assistant- Introduction to Methods in Learning and Memory Research Biosciences (Bachelor) Ruprecht Karls Universität Heidelberg, Alemanha
2016/06/06 - 2016/06/10 Teaching Assistant- Introduction to Methods in Learning and Memory Research Biosciences (Bachelor) Ruprecht Karls Universität Heidelberg, Alemanha

Entrevista / Programa (rádio / tv)

Programa Tema
2025/10 - Atual Sociedade civil Memory
2024/06 - Atual 90 Segundos de Ciência

Membro de associação

Nome da associação Tipo de participação
2018/01/01 - Atual Molecular and Cellular Cognition Society (MCCS) Member
2016/01/01 - Atual Dutch Neurofederation Network Member
2016/01/01 - Atual European Molecular and Cellular Cognition Society (EMCCS) Member
2016/01/01 - Atual Portuguese Neuroscience Society (SPN) Efective Member
2014/01/01 - Atual ANCiB-Associação Nacional de Ciências Biomédicas Founder member
2018/01/01 - 2018/12/31 Society for Neuroscience (SfN) Member

Membro de comissão

Descrição da atividade
Tipo de participação 		Instituição / Organização
2023 - 2027 Elected Junior Committee Representative, Portuguese Society for Neuroscience (SPN; 2023–2027): coordination of national seminar series and science communication channels
Coordenador
2026/01 - 2026/10 Member of the organizing committee for ESN-ISN Advanced School for Neurochemistry.
Membro
2018/10/01 - 2019/07/14 Invited member for the Scientific Committee of the annual Interdisciplinary Center for Neuroscience Conference (IZN, a consortium of >60 laboratories). Together with three principal investigators and a research coordinator we selected and invited the speakers for this conference.
Coordenador
 Ruprecht Karls Universität Heidelberg, Alemanha

Outro júri / avaliação

Descrição da atividade Instituição / Organização
2021/12/14 - 2021/12/15 Jury for the annual Ph.D. students progress evaluation (PhD programme in Biomedical Sciences) Universidade do Algarve, Portugal
Distinções

Prémio

2026 Travel award
European Society for Neurochemistry (ESN), Reino Unido
2025 IZN/Chica and Heinz Schaller Young Investigator Neuroscience Award 2025
Chica und Heinz Schaller-Stiftung, Alemanha
2025 Travel award
Sociedade Portuguesa de Neurociências, Portugal
2024 Travel grant
Sociedade Portuguesa de Neurociências, Portugal
2024 Travel Award
European Society for Neurochemistry (ESN), Reino Unido
2023 Best Oral Communication Award
2022 Post-Doc Fellowship
2022 Foundation BrainAid IZN Dissertation Award 2022
Foundation BrainAid , Alemanha
2022 Best Oral Communication Award
Universidade do Algarve Centro Académico de Investigação e Formação Biomédica do Algarve, Portugal
2022 Ruprecht-Karls Award (2nd placd)
Universität Heidelberg Fakultät für Biowissenschaften, Alemanha
2020 PhD Fellowship
Deutsche Forschungsgemeinschaft, Alemanha
2020 Travel grant
Sociedade Portuguesa de Neurociências, Portugal
2019 Completion PhD Fellowship
Ruprecht Karls Universität Heidelberg, Alemanha
2018 Travel grant
Ruprecht Karls Universität Heidelberg, Alemanha
2018 Honorable Mention for best poster presentation
IZN Retreat Scientific Comission, Alemanha
2017 Travel grant
Sociedade Portuguesa de Neurociências, Portugal
2014 ERASMUS+ Fellowship

Título

2023 Representative for the Junior Committee of SPN
Sociedade Portuguesa de Neurociências, Portugal