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Fernando Ferreira is graduated in Veterinary Medicine (2001) and obtained his PhD degree in Veterinary Sciences at the Faculty of Veterinary Medicine (2008), University of Lisbon. During his PhD, he characterized the functional role and the dynamics of cellular Topoisomerases in replication of genomes, and explored the interaction between the Williams syndrome transcription factor and PCNA in DNA replication foci. In 2008, Fernando Ferreira was awarded by the Prize Young Researchers (UTL/Caixa Geral de Depósitos) due to the merit of published scientific manuscripts. Since 2009, he works on the molecular characterization of feline mammary carcinoma (FMC) aiming to discover diagnostic biomarkers and novel molecular targets for precision chemotherapy and immunotherapy, under the financial support of national research projects. The main discoveries in this field were the validation of a molecular classification system for FMC, uncover the importance of serum HER2 as a diagnostic biomarker, characterize the antitumoral effects of anti-HER2 agents, describe the pathological and clinical implications of the tumor-infiltrating immune cells and evaluate the role of several immunocheckpoints in the tumor microenvironment on different FMC molecular subtypes. In parallel, Fernando Ferreira is also working in the Infectious Disease Laboratory of FMV, collaborating with an international highly diversified network of research labs in order to develop cutting-edge projects aiming to discovery efficient antivirals and develop rational vaccine candidates against African swine fever virus (ASFV) with DIVA features. Currently, African Swine Fever is present in the 5 continents, being the most serious disease threatening the pig industry, since no vaccine or antiviral treatment is available. Ongoing studies allow to better understand host cell-African swine fever virus (ASFV) interactions through functional studies on biological activity of several ASFV proteins involved in viral genome replication, in the identification of immunodominant-B cell antigens, providing a solid rational to design novel antiviral molecules and vaccine prototypes. In 2019, Fernando Ferreira was awarded by the Prize "Universidade de Lisboa/Caixa Geral de Depósitos". After his PhD, Fernando Ferreira published over 50 papers in international peer review journals (44 as 1st author or last author, h-index=22, citations=1183), supervised 9 PhD students (7 completed), 40 MSc thesis and 3 Post-Doc researchers. PI of several nacional research projects on veterinary oncology and virology, F Ferreira had participate as researcher in 3 European projects on African Swine Fever Virus (ASFRISK, ASFSTOP, VACDIVA). He is also author of oral communications in more than 50 international meetings, 20 national meetings and poster presentations in other 35 international scientific meetings. He is a reviewer for many international scientific journals, including Nature Communications, Scientific Reports, PLOS pathogens, Cancers, Biomedicines and Vaccines. Between 2016 and 2022 was the President of the Portuguese Society of Veterinary Sciences and since 2023, F Ferreira holds the position of the associate professor at the Faculty of Veterinary Medicine, University of Lisbon, being involved in teaching activities in the subjects of Anatomy and Cell Culture.
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Identificação

Identificação pessoal

Nome completo
Fernando António da Costa Ferreira

Nomes de citação

  • Ferreira, Fernando

Identificadores de autor

Ciência ID
F81F-D7D4-57C5
ORCID iD
0000-0001-5765-576X
Google Scholar ID
https://scholar.google.pt/citations?hl=en&user=vAmusIMAAAAJ&view_op=list_works&sortby=pubdate
Scopus Author Id
57226822508

Endereços de correio eletrónico

  • fernandof@fmv.ulisboa.pt (Profissional)

Domínios de atuação

  • Ciências Agrárias - Ciências Veterinárias

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português (Idioma materno)
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Francês Utilizador elementar (A2) Utilizador independente (B1) Utilizador elementar (A1) Utilizador elementar (A2) Utilizador elementar (A1)
Formação
Grau Classificação
1994/10/01 - 2020/06/30
Concluído
 Medicina Veterinária (Licenciatura)
Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
 16
2008/10
Concluído
 Medicina Veterinária (Doutoramento)
Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
Percurso profissional

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2023/04/01 - Atual Professor Associado (Docente Universitário) Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal

Cargos e Funções

Categoria Profissional
Instituição de acolhimento 		Empregador
2008/10/08 - 2023/04/01 Assistant Professor Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
Projetos

Bolsa

Designação Financiadores
2019/10/01 - Atual VACDIVA - A vaccine against African swine fever
Grant agreement ID: 862874
Investigador
Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
Em curso

Projeto

Designação Financiadores
2021/01/01 - 2025/12/31 Laboratório Associado para Ciência Animal e Veterinária
LA/P/0059/2020
10.54499/LA/P/0059/2020
Universidade de Lisboa Centro de Investigação Interdisciplinar em Sanidade Animal, Portugal

Universidade de Trás-os-Montes e Alto Douro, Portugal

Universidade do Porto Instituto de Ciências Tecnologias e Agroambiente, Portugal

Universidade de Trás-os-Montes e Alto Douro Centro de Ciência Animal e Veterinária, Portugal

Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal

Universidade do Porto Centro de Estudos de Ciencia Animal, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2023/03/12 - 2024/09/11 Desenvolvimento de novos conjugados anticorpo-enzima para imunoterapia do cancro através de edição do glicocálice no carcinoma mamário felino
2022.07903.PTDC
Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2016/05 - 2020/05 Understanding and combating African Swine Fever in Europe (ASF-STOP)
CA15116
 Horizon 2020
2019/01/01 - 2019/12/31 Centro de Investigação Interdisciplinar em Sanidade Animal
UID/CVT/00276/2019
Universidade de Lisboa Centro de Investigação Interdisciplinar em Sanidade Animal, Portugal

Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2016/05/15 - 2019/11/14 Avaliação molecular do proto-oncogene HER2 e das topoisomerases no carcinoma mamário felino - Desenvolvimento de novas estratégias para melhorar o diagnóstico e a imunoquimioterapia
PTDC/CVT-EPI/3638/2014
Universidade de Lisboa Centro de Investigação Interdisciplinar em Sanidade Animal, Portugal

Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2016/01 - 2019/11 Molecular evaluation of HER2 and Topoisomerases in feline mammary carcinoma - Developing rational stratagies for effective diagnosis and cancer chemoimmunotherapy
grant.Provided by PTCRIS: 142267
Investigador responsável
Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
 Foundation for Science and Technology
Em curso
2012/10 - 2015/09 Targeted research effort on African swine fever - ASFORCE
FP7 - KBBE.2012.1.3-02
 European Union's Seventh Framework Programme (FP7/2007-2013)
2011/01/01 - 2013/12/31 Strategic Project - UI 276 - 2011-2012
PEst-OE/AGR/UI0276/2011
Universidade de Lisboa Centro de Investigação Interdisciplinar em Sanidade Animal, Portugal

Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2010/03/01 - 2013/08/31 Papel da topoisomerase II do vírus da peste suína africana (VPSA) na replicação do DNA viral - um possível alvo para terapia antiviral
PTDC/CVT/105630/2008
Universidade de Lisboa Centro de Investigação Interdisciplinar em Sanidade Animal, Portugal

Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2010/03 - 2013/08 Role of African swine fever virus (ASFV) topoisomerase II in viral DNA replication - a possible target for antiviral therapy
grant.Provided by PTCRIS: 105630
 Foundation for Science and Technology
2005/02 - 2007/11 Topoisomerases: at the border between DNA replication and chromatin structure
grant.Provided by PTCRIS: 63368
 Foundation for Science and Technology
Produções

Publicações

Artigo em revista
  1. Daniela Cunha; Marco Neves; Daniela Silva; Ana Rita Silvestre; Paula Borralho Nunes; Fernando Arrobas; Julie C. Ribot; et al. "Tumor-Infiltrating T Cells in Skin Basal Cell Carcinomas and Squamous Cell Carcinomas: Global Th1 Preponderance with Th17 Enrichment—A Cross-Sectional Study". Cells (2024): https://doi.org/10.3390/cells13110964.
    10.3390/cells13110964
  2. Ana Catarina Urbano; Nicolas Ferreira; Nuno Jordão; Fernando Boinas; Carlos Martins; Fernando Ferreira. "Targeted mutagenesis of the ß-strand DNA binding region of African swine fever virus histone-like protein (pA104R) impairs DNA-binding activity and antibody recognition". Antiviral Research (2024): https://doi.org/10.1016/j.antiviral.2023.105784.
    10.1016/j.antiviral.2023.105784
  3. Sofia Valente; Catarina Nascimento; Andreia Gameiro; João Ferreira; Correia, JJ; Fernando Ferreira. "TIM-3 Is a Potential Immune Checkpoint Target in Cats with Mammary Carcinoma". Cancers (2023): https://www.mdpi.com/2072-6694/15/2/384.
    10.3390/cancers15020384
  4. Ana Catarina Urbano; Fernando Ferreira. "African swine fever control and prevention: an update on vaccine development". Emerging Microbes & Infections (2022): https://doi.org/10.1080/22221751.2022.2108342.
    10.1080/22221751.2022.2108342
  5. Daniela Ferreira; Maria Soares; Jorge Correia; Filomena Adega; Fernando Ferreira; Raquel Chaves. "Satellite Noncoding RNAs (ncRNA) as Cancer Biomarkers? New Insights from FA-SAT ncRNA Molecular and Clinical Profiles in Feline Mammary Tumors". OMICS: A Journal of Integrative Biology (2022): https://doi.org/10.1089/omi.2022.0114.
    10.1089/omi.2022.0114
  6. Fernando Ferreira. "Transcription profiling of feline mammary carcinomas and derived cell lines reveals biomarkers and drug targets associated with metabolic and cell cycle pathways". Scientific Reports 12 1 (2022): http://dx.doi.org/10.1038/s41598-022-20874-5.
    10.1038/s41598-022-20874-5
  7. Catarina Nascimento; Andreia Gameiro; Jorge Correia; João Ferreira; Fernando Ferreira. "The Landscape of Tumor-Infiltrating Immune Cells in Feline Mammary Carcinoma: Pathological and Clinical Implications". Cells 11 16 (2022): 2578-2578. https://doi.org/10.3390/cells11162578.
    10.3390/cells11162578
  8. Maria Soares; Assunção N. Correia; Mariana R. Batista; Jorge Correia; Fernando Ferreira. "fHER2, PR, ER, Ki-67 and Cytokeratin 5/6 Expression in Benign Feline Mammary Lesions". Animals 12 13 (2022): 1599-1599. https://doi.org/10.3390/ani12131599.
    10.3390/ani12131599
  9. "Antiviral activity of brequinar against African swine fever virus infection in vitro.". Virus research (2022): https://doi.org/10.1016/j.virusres.2022.198826.
    10.1016/j.virusres.2022.198826
  10. Ferreira, Daniela; Soares, Maria; Correira, Jorge; Adega, Filomena; Ferreira, Fernando; Chaves, Raquel. "FA-SAT ncRNA as a putative cancer biomarker in feline mammary tumours". (2022):
    Submetido
  11. Andreia Gameiro; Catarina Nascimento; Jorge Correia; Fernando Ferreira. "VISTA Is a Diagnostic Biomarker and Immunotherapy Target of Aggressive Feline Mammary Carcinoma Subtypes". Cancers 13 21 (2021): 5559-5559. https://doi.org/10.3390/cancers13215559.
    10.3390/cancers13215559
  12. "Flavonoid Library Screening Reveals Kaempferol as a Potential Antiviral Agent Against African Swine Fever Virus". Frontiers in Microbiology 12 (2021): http://dx.doi.org/10.3389/fmicb.2021.736780.
    10.3389/fmicb.2021.736780
  13. Andreia Gameiro; Ana Urbano; Fernando Ferreira. "Emerging Biomarkers and Targeted Therapies in Feline Mammary Carcinoma". Veterinary Sciences (2021): https://doi.org/10.3390/vetsci8080164.
    10.3390/vetsci8080164
  14. "Tumor microenvironment of human breast cancer, and feline mammary carcinoma as a potential study model". Biochimica et Biophysica Acta (BBA) - Reviews on Cancer (2021): 188587-188587. http://dx.doi.org/10.1016/j.bbcan.2021.188587.
    10.1016/j.bbcan.2021.188587
  15. Maria Soares; Correia, JJ; Catarina Nascimento; Fernando Ferreira. "Anaplastic Mammary Carcinoma in Cat". Veterinary Sciences (2021): https://www.mdpi.com/2306-7381/8/5/77.
    10.3390/vetsci8050077
  16. Andreia Gameiro; Catarina Nascimento; Jorge Correia; Fernando Ferreira. "HER2-Targeted Immunotherapy and Combined Protocols Showed Promising Antiproliferative Effects in Feline Mammary Carcinoma Cell-Based Models". Cancers (2021): https://doi.org/10.3390/cancers13092007.
    10.3390/cancers13092007
  17. Ferreira, Fernando. "A new microtubule-stabilizing agent shows potent antiviral effects against African swine fever virus with no cytotoxicity.". Emerging microbes & infections (2021): https://doi.org/10.1080/22221751.2021.1902751.
    10.1080/22221751.2021.1902751
  18. Andreia Gameiro; Filipe Almeida; Catarina Nascimento; Jorge Correia; Fernando Ferreira. "Tyrosine Kinase Inhibitors Are Promising Therapeutic Tools for Cats with HER2-Positive Mammary Carcinoma". Pharmaceutics 13 3 (2021): 346-346. https://doi.org/10.3390/pharmaceutics13030346.
    10.3390/pharmaceutics13030346
  19. Filipe Almeida; Andreia Gameiro; Jorge Correia; Fernando Ferreira. "Histone Deacetylase Inhibitors and Microtubule Inhibitors Induce Apoptosis in Feline Luminal Mammary Carcinoma Cells". Animals 11 2 (2021): 502-502. https://doi.org/10.3390/ani11020502.
    10.3390/ani11020502
  20. Ferreira, Fernando. "Serum and Tissue Expression Levels of Leptin and Leptin Receptor Are Putative Markers of Specific Feline Mammary Carcinoma Subtypes". Frontiers in Veterinary Science (2021):
    10.3389/fvets.2021.625147
  21. Catarina Nascimento; Andreia Gameiro; João Ferreira; Jorge Correia; Fernando Ferreira. "Diagnostic Value of VEGF-A, VEGFR-1 and VEGFR-2 in Feline Mammary Carcinoma". Cancers (2021): https://doi.org/10.3390/cancers13010117.
    10.3390/cancers13010117
  22. Ferreira, Fernando. "Clinical Relevance of the serum CTLA-4 in Cats with Mammary Carcinoma". Scientific Reports (2020): http://dx.doi.org/10.1038/s41598-020-60860-3.
    10.1038/s41598-020-60860-3
  23. Ana Catarina Urbano; Fernando Ferreira. "Role of the DNA-Binding Protein pA104R in ASFV Genome Packaging and as a Novel Target for Vaccine and Drug Development". Vaccines 8 4 (2020): 585-585. https://doi.org/10.3390/vaccines8040585.
    10.3390/vaccines8040585
  24. Catarina Nascimento; Ana Catarina Urbano; Andreia Gameiro; João Ferreira; Jorge Correia; Fernando Ferreira. "Serum PD-1/PD-L1 Levels, Tumor Expression and PD-L1 Somatic Mutations in HER2-Positive and Triple Negative Normal-Like Feline Mammary Carcinoma Subtypes". Cancers 12 6 (2020): 1386-1386. https://doi.org/10.3390/cancers12061386.
    10.3390/cancers12061386
  25. Ferreira, Fernando. "African swine fever virus replication events and cell nucleus: New insights and perspectives". Virus Research (2019): http://dx.doi.org/10.1016/j.virusres.2019.197667.
    10.1016/j.virusres.2019.197667
  26. Daniela Ferreira; Yves St-Pierre; Bárbara Martins; Maria Soares; Jorge Correia; Filomena Adega; Fernando Ferreira; Raquel Chaves. "Gene expression association study in feline mammary carcinomas". PLOS ONE (2019): https://doi.org/10.1371/journal.pone.0221776.
    10.1371/journal.pone.0221776
  27. Ferdinando B. Freitas; Margarida Simões; Gonçalo Frouco; Carlos Martins; Fernando Ferreira. "Towards the Generation of an ASFV-pA104R DISC Mutant and a Complementary Cell Line—A Potential Methodology for the Production of a Vaccine Candidate". Vaccines (2019): https://doi.org/10.3390/vaccines7030068.
    10.3390/vaccines7030068
  28. Ferreira, Fernando. "Assessment of ERBB2 and TOP2a gene status and expression profile in feline mammary tumors: findings and guidelines.". Aging (2019): https://doi.org/10.18632/aging.102079.
    10.18632/aging.102079
  29. Ferreira, Fernando. "Inhibition of African swine fever virus infection by genkwanin". (2019): http://dx.doi.org/10.1016/j.antiviral.2019.04.008.
    10.1016/j.antiviral.2019.04.008
  30. Ferdinando B. Freitas; Gonçalo Frouco; Carlos Martins; Fernando Ferreira. "The QP509L and Q706L superfamily II RNA helicases of African swine fever virus are required for viral replication, having non-redundant activities". Emerging Microbes & Infections (2019): https://doi.org/10.1080/22221751.2019.1578624.
    10.1080/22221751.2019.1578624
  31. Ferdinando B. Freitas; Gonçalo Frouco; Carlos Martins; Fernando Ferreira. "African swine fever virus encodes for an E2-ubiquitin conjugating enzyme that is mono- and di-ubiquitinated and required for viral replication cycle". Scientific Reports 8 1 (2018): https://doi.org/10.1038/s41598-018-21872-2.
    10.1038/s41598-018-21872-2
  32. Erik Arabyan; Astghik Hakobyan; Armen Kotsinyan; Zaven Karalyan; Vahram Arakelov; Grigor Arakelov; Karen Nazaryan; et al. "Genistein inhibits African swine fever virus replication in vitro by disrupting viral DNA synthesis". Antiviral Research 156 (2018): 128-137. https://doi.org/10.1016/j.antiviral.2018.06.014.
    10.1016/j.antiviral.2018.06.014
  33. Cláudia S. Marques; Ana Rita Santos; Andreia Gameiro; Jorge Correia; Fernando Ferreira. "CXCR4 and its ligand CXCL12 display opposite expression profiles in feline mammary metastatic disease, with the exception of HER2-overexpressing tumors". BMC Cancer 18 1 (2018): https://doi.org/10.1186%2Fs12885-018-4650-9.
    10.1186/s12885-018-4650-9
  34. Ferreira, Fernando. "CXCL12-CXCR4 axis in feline mammary carcinoma.". Aging (2017): http://europepmc.org/abstract/med/29232654.
    10.18632/aging.101344
  35. Cláudia S. Marques; Maria Soares; Ana Santos; Jorge Correia; Fernando Ferreira. "Serum SDF-1 levels are a reliable diagnostic marker of feline mammary carcinoma, discriminating HER2-overexpressing tumors from other subtypes". Oncotarget (2017): https://doi.org/10.18632%2Foncotarget.22398.
    10.18632/oncotarget.22398
  36. Ferreira, Fernando. "Sodium phenylbutyrate abrogates African swine fever virus replication by disrupting the virus-induced hypoacetylation status of histone H3K9/K14.". Virus research (2017): http://europepmc.org/abstract/med/28916365.
    10.1016/j.virusres.2017.09.009
  37. Frouco, G.; Freitas, F.B.; Coelho, J.; Leitão, A.; Martins, C.; Ferreira, F.; Frouco G; et al. "DNA-binding properties of African swine fever virus pA104R, a histone-like protein involved in viral replication and transcription". Journal of Virology 91 12 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85019693151&partnerID=MN8TOARS.
    10.1128/JVI.02498-16
  38. Soares, M.; Correia, J.; Peleteiro, M.C.; Ferreira, F.. "St Gallen molecular subtypes in feline mammary carcinoma and paired metastases—disease progression and clinical implications from a 3-year follow-up study". Tumor Biology 37 3 (2016): 4053-4064. http://www.scopus.com/inward/record.url?eid=2-s2.0-84944909120&partnerID=MN8TOARS.
    10.1007/s13277-015-4251-z
  39. Soares, M.; Ribeiro, R.; Carvalho, S.; Peleteiro, M.; Correia, J.; Ferreira, F.. "Ki-67 as a Prognostic Factor in Feline Mammary Carcinoma: What Is the Optimal Cutoff Value?". Veterinary Pathology 53 1 (2016): 37-43. http://www.scopus.com/inward/record.url?eid=2-s2.0-84952002585&partnerID=MN8TOARS.
    10.1177/0300985815588606
  40. Coelho, J.; Ferreira, F.; Martins, C.; Leitão, A.. "Functional characterization and inhibition of the type II DNA topoisomerase coded by African swine fever virus". Virology 493 (2016): 209-216. http://www.scopus.com/inward/record.url?eid=2-s2.0-84962385207&partnerID=MN8TOARS.
    10.1016/j.virol.2016.03.023
  41. Soares, M.; Madeira, S.; Correia, J.; Peleteiro, M.; Cardoso, F.; Ferreira, F.. "Molecular based subtyping of feline mammary carcinomas and clinicopathological characterization". Breast 27 (2016): 44-51. http://www.scopus.com/inward/record.url?eid=2-s2.0-84961207018&partnerID=MN8TOARS.
    10.1016/j.breast.2016.02.016
  42. Soares, M.; Ribeiro, R.; Najmudin, S.; Gameiro, A.; Rodrigues, R.; Cardoso, F.; Ferreira, F.. "Serum HER2 levels are increased in cats with mammary carcinomas and predict tissue HER2 status". Oncotarget 7 14 (2016): 17314-17326. http://www.scopus.com/inward/record.url?eid=2-s2.0-84975527510&partnerID=MN8TOARS.
    10.18632/oncotarget.7551
  43. Marques, C.; Correia, J.; Ferreira, F.. "HER2-positive feline mammary carcinoma". Aging 8 8 (2016): 1574-1575. http://www.scopus.com/inward/record.url?eid=2-s2.0-84987916097&partnerID=MN8TOARS.
    10.18632/aging.101015
  44. Freitas, F.B.; Frouco, G.; Martins, C.; Leitão, A.; Ferreira, F.. "In vitro inhibition of African swine fever virus-topoisomerase II disrupts viral replication". Antiviral Research 134 (2016): 34-41. http://www.scopus.com/inward/record.url?eid=2-s2.0-84984843583&partnerID=MN8TOARS.
    10.1016/j.antiviral.2016.08.021
  45. Simões M; Martins C; Ferreira F. "Early intranuclear replication of African swine fever virus genome modifies the landscape of the host cell nucleus.". (2015): http://europepmc.org/abstract/med/26183880.
    10.1016/j.virusres.2015.07.006
  46. Coelho J; Martins C; Ferreira F; Leitão A. "African swine fever virus ORF P1192R codes for a functional type II DNA topoisomerase.". (2015): http://europepmc.org/abstract/med/25463606.
    10.1016/j.virol.2014.10.034
  47. Ferreira, F.C.; Soares, M.J.; Carvalho, S.; Borralho, L.; Vicente, G.; Branco, S.; Correia, J.; Peleteiro, M.C.. "Four cases of cell cannibalism in highly malignant feline and canine tumors". Diagnostic Pathology 10 1 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84959077913&partnerID=MN8TOARS.
    10.1186/s13000-015-0429-3
  48. Simões, M.; Rino, J.; Pinheiro, I.; Martins, C.; Ferreira, F.. "Alterations of nuclear architecture and epigenetic signatures during African swine fever virus infection". Viruses 7 9 (2015): 4978-4996. http://www.scopus.com/inward/record.url?eid=2-s2.0-84941632468&partnerID=MN8TOARS.
    10.3390/v7092858
  49. Simões, M.; Martins, C.; Ferreira, F.. "Host DNA damage response facilitates African swine fever virus infection". Veterinary Microbiology 165 1-2 (2013): 140-147. http://www.scopus.com/inward/record.url?eid=2-s2.0-84878645824&partnerID=MN8TOARS.
    10.1016/j.vetmic.2013.01.007
  50. Soares, M.; Correia, J.; Rodrigues, P.; Simões, M.; De Matos, A.; Ferreira, F.. "Feline HER2 protein expression levels and gene status in feline mammary carcinoma: Optimization of immunohistochemistry (IHC) and in situ hybridization (ISH) techniques". Microscopy and Microanalysis 19 4 (2013): 876-882. http://www.scopus.com/inward/record.url?eid=2-s2.0-84880270936&partnerID=MN8TOARS.
    10.1017/S1431927613001529
  51. Mottola, C.; Freitas, F.B.; Simões, M.; Martins, C.; Leitão, A.; Ferreira, F.. "In vitro antiviral activity of fluoroquinolones against African swine fever virus". Veterinary Microbiology 165 1-2 (2013): 86-94. http://www.scopus.com/inward/record.url?eid=2-s2.0-84878652564&partnerID=MN8TOARS.
    10.1016/j.vetmic.2013.01.018
  52. Soares, M.; Correia, J.; Cabeçadas, J.; Peleteiro, C.; Ferreira, F.. "The value of a new cancer biomarker fHER-2 proto-oncogene in the diagnosis of feline mammary carcinoma". Proceedings of the International Workshop on Veterinary Biosignals and Biodevices, VBB 2012, in Conjunction with BIOSTEC 2012 (2012): 9-17. http://www.scopus.com/inward/record.url?eid=2-s2.0-84861972925&partnerID=MN8TOARS.
  53. Agostinho, M.; Santos, V.; Ferreira, F.; Costa, R.; Cardoso, J.; Pinheiro, I.; Rino, J.; et al. "Conjugation of human topoisomerase 2a with small ubiquitin-like modifiers 2/3 in response to topoisomerase inhibitors: Cell cycle stage and chromosome domain specificity". Cancer Research 68 7 (2008): 2409-2418. http://www.scopus.com/inward/record.url?eid=2-s2.0-42049102803&partnerID=MN8TOARS.
    10.1158/0008-5472.CAN-07-2092
  54. Agostinho, M.; Rino, J.; Braga, J.; Ferreira, F.; Steffensen, S.; Ferreira, J.. "Human Topoisomerase IIa: Targeting to Subchromosomal Sites of Activity during Interphase and Mitosis". Molecular Biology of the Cell 15 5 (2004): 2388-2400. http://www.scopus.com/inward/record.url?eid=2-s2.0-2342564452&partnerID=MN8TOARS.
    10.1091/mbc.E03-08-0558
  55. Poot, R.A.; Bozhenok, L.; van den Berg, D.L.C.; Steffensen, S.; Ferreira, F.; Grimaldi, M.; Gilbert, N.; Ferreira, J.; Varga-Weisz, P.D.. "The Williams syndrome transcription factor interacts with PCNA to target chromatic remodelling by ISWI to replication foci". Nature Cell Biology 6 12 (2004): 1236-1244. http://www.scopus.com/inward/record.url?eid=2-s2.0-10344261484&partnerID=MN8TOARS.
    10.1038/ncb1196
Capítulo de livro
  1. Ferreira, Fernando. "African swine fever virus: cellular and molecular aspects". In Understanding and combatting African Swine Fever - A European perspective, 25-61. Wageningen, Países Baixos: Wageningen Academic Publishers, 2021.
    Aceite para publicação
  2. Ferreira, Fernando. "Conclusions". In Understanding and combatting African Swine Fever - A European perspective, 305-301. Wageningen, Países Baixos: Wageningen Academic Publishers, 2021.
    Aceite para publicação
  3. Ferreira, J.A.; Neves, M.; Alpalhão, M.; Pereira, P.; Cunha, D.; Ferreira, F.; Santus, R.; Sousa, A.E.; Filipe, P.L.. "EDU (5-Ethynyl-2'-Deoxyuridine)-Coupled Fluorescence-Intensity Analysis: Determining Absolute Parameters of the Cell Cycle". 165-177. 2021.
    10.1007/978-1-0716-1538-6_12
  4. Ferreira, Fernando. "Feline Mammary Carcinoma: Past, Present and Future". 419-435. Springer International Publishing, 2020.
    10.1007/978-3-030-61981-7_23
Poster em conferência
  1. Martins, Bárbara; Ferreira, Daniela; Soares, Maria; Adega, Filomena; Ferreira, Fernando; Chaves, Raquel. "Disclosing the PKM2 expression profile in cat mammary tumours". Trabalho apresentado em IX Jornadas de Genética e Biotecnologia, 2017.
Pré-impressão
  1. Catarina Nascimento; Ana Catarina Urbano; Andreia Gameiro; João Ferreira; Jorge Correia; Fernando Ferreira. "PD-1 and PD-L1 are diagnostic biomarkers and PD-L1 a promising therapeutic target in HER2-positive and triple negative normal-like feline mammary carcinoma subtypes". 2020. https://doi.org/10.1101/2020.04.25.061655.
    10.1101/2020.04.25.061655

Outros

Outra produção
  1. Serum levels and tumour expression of leptin and leptin receptor as promising clinical biomarkers of specific feline mammary carcinoma subtypes. 2020. Andreia Gameiro; Catarina Nascimento; Ana Catarina Urbano; Jorge Correia; Fernando Ferreira. https://doi.org/10.1101/2020.04.27.064600.
    10.1101/2020.04.27.064600
Atividades

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2020/06/05 - 2024 Development of a live attenuated African swine fever (ASF) differentiating infected from vaccinated animals (DIVA) vaccine platform based on a pA104R mutant.
Orientador de Ana Catarina Fernandes Urbano
Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
2020/06/05 - 2024 Functional impairment and antigen hindering of E2 ubiquitin-conjugating enzyme I215L, towards the development of a live attenuated vaccine against African Swine Fever Virus
Orientador de Nuno Ricardo de Oliveira Jordão
Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
2019/04/01 - 2022/04/01 Characterization of immune responses in feline mammary carcinoma towards the development of improved diagnostic tools and molecular therapies
Orientador de Ana Catarina Nascimento
Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
2017/10/01 - 2021/12/31 Developing diagnostic tools for feline mammary carcinomas and improving chemotherapy based on HER2 and topoisometase IIalpha status.
Orientador de Andreia Pereira Gameiro
Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
2014/04/01 - 2018 Dissecting the role of African Swine Fever Virus (ASFV) ubiquitin-conjugating E2-like enzyme and topoisomerase type II towards vaccine development
Orientador de Ferdinando Bernardino de Freitas
Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
2014 - 2018 Modulating chromatin structure and gene expression during African Swine Fever Virus infection – New strategies for an efficient vaccine rational design
Orientador de Gonçalo Frouco
Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
2011 - 2015 Molecular cytogenetic analysis of Feline Mammary Carcinoma: correlation of morphological changes with DNA, mRNA and protein expression levels of two possible prognostic factors HER-2 and TOP2A – New insights to improve diagnosis and adjuvant chemotherapy
Orientador
Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
2010 - 2015 Spatiotemporal study of morpho-functional modifications on cell nucleus during African Swine Fever Virus early phase of infection
Orientador de Margarida Pires Simões
Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
2010 - 2015 Molecular characterization and functional analysis of ORF P1192R from African swine fever virus
Coorientador
Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal

Membro de associação

Nome da associação Tipo de participação
2016/04/01 - 2022/03/01 Portuguese Society of Veterinary Sciences President
Distinções

Prémio

2019 Scientific Awards ULisboa/Caixa Geral de Depósitos (Veterinary Sciences)
Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
2008 Young Researcher UTL/Caixa Geral de Depósitos (Veterinary Sciences)
Universidade de Lisboa, Portugal

Outra distinção

2018 Honorable mention - Scientific Awards ULisboa/Caixa Geral de Depósitos (Veterinary Sciences)
Universidade de Lisboa, Portugal
2017 Honorable mention - Scientific Awards ULisboa/Caixa Geral de Depósitos (Veterinary Sciences)
Universidade de Lisboa, Portugal