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Identificação

Identificação pessoal

Nome completo
Sandra Laurentino

Nomes de citação

  • Laurentino, Sandra

Identificadores de autor

Ciência ID
E615-D7B9-FB1F
ORCID iD
0000-0002-5213-2756
Formação
Grau Classificação
2006
Concluído
 Biomedicina (Doutoramento)
Especialização em Sem especialidade
Universidade da Beira Interior, Portugal
"The Androgen Receptor in Male Fertility: Study of Polimorphic and Alternative Mrna Transcripts" (TESE/DISSERTAÇÃO)
Projetos

Bolsa

Designação Financiadores
2017/01 - Atual Molecular mechanisms of spermatogenic failure at transcriptional and epigenetic level
388866485
 Deutsche Forschungsgemeinschaft
2017/01 - Atual KFO 326:  Male Germ Cells: from Genes to Function
329621271
 Deutsche Forschungsgemeinschaft
2022 - 2025 Impact of ageing on the human male germline
LA 4064/4-1
 Deutsche Forschungsgemeinschaft
2019/06 - 2020/05 The roadmap of male germ cell development: a single-cell transcriptome approach
LA221806
 Westfälische Wilhelms-Universität Münster Fachbereich 05 Medizinische Fakultät
2018/10 - 2019/10 Single-cell transcriptome analysis to dissect the interaction between soma and germline in the human testis
CRU326
 Deutsche Forschungsgemeinschaft
2014 - 2017 The Human X-linked Reproductive Homeobox (RHOX) Genes and Spermatogenesis
LA121315
 Westfälische Wilhelms-Universität Münster Fachbereich 05 Medizinische Fakultät
2015 - 2016 Epigenetic heterogeneity in human spermatogonia unravelled by next-generation sequencing: do individual methylation patterns dictate stem cell behaviour?
LA211518
 Westfälische Wilhelms-Universität Münster Fachbereich 05 Medizinische Fakultät
2012 - 2013 Laser Capture Microdissection technology to study DNA methylation status in human testicular cells
LA211205
 Westfälische Wilhelms-Universität Münster Fachbereich 05 Medizinische Fakultät
2007/02 - 2011/01 THE ANDROGEN RECEPTOR IN MALE FERTILITY: STUDY OF POLYMORPHIC REPEATS AND ALTERNATIVE MRNA TRANSCRIPTS
490722097
 Fundação para a Ciência e a Tecnologia
2007/02 - 2011/01 THE ANDROGEN RECEPTOR IN MALE FERTILITY: STUDY OF POLYMORPHIC REPEATS AND ALTERNATIVE MRNA TRANSCRIPTS
Provided by PTCRIS: SFRH/BD/30173/2006
 Fundação para a Ciência e a Tecnologia

Projeto

Designação Financiadores
2007/02/01 - 2011/01/31 THE ANDROGEN RECEPTOR IN MALE FERTILITY: STUDY OF POLYMORPHIC REPEATS AND ALTERNATIVE MRNA TRANSCRIPTS
SFRH/BD/30173/2006
 Fundação para a Ciência e a Tecnologia
Concluído
Produções

Publicações

Artigo em revista
  1. Sven Berres; Jörg Gromoll; Marius Wöste; Sarah Sandmann; Sandra Laurentino. "OGRE: calculate, visualize, and analyze overlap between genomic input regions and public annotations". BMC Bioinformatics (2023): https://doi.org/10.1186/s12859-023-05422-w.
    10.1186/s12859-023-05422-w
  2. Mirkka Hiort; Julia Rohayem; Regine Knaf; Sandra Laurentino; Agnethe Berglund; Claus H. Gravholt; Jörg Gromoll; Joachim Wistuba. "Testicular Architecture of Men with 46,XX Testicular Disorders of Sex Development". Sexual Development (2023): https://doi.org/10.1159/000528955.
    10.1159/000528955
  3. Siebert-Kuss, L.M.; Krenz, H.; Tekath, T.; Wöste, M.; Di Persio, S.; Terwort, N.; Wyrwoll, M.J.; et al. "Transcriptome analyses in infertile men reveal germ cell-specific expression and splicing patterns". Life science alliance 6 2 (2023): http://www.scopus.com/inward/record.url?eid=2-s2.0-85143079542&partnerID=MN8TOARS.
    10.26508/lsa.202201633
  4. Mehul Patel; Akhil Muthigi; Sandra Laurentino; Parris Diaz; Ranjith Ramasamy. "Male reproductive aging: can men with oligospermia become azoospermic over time?". International Journal of Impotence Research (2022): https://doi.org/10.1038/s41443-022-00634-9.
    10.1038/s41443-022-00634-9
  5. "Whole-genome methylation analysis of testicular germ cells from cryptozoospermic men points to recurrent and functionally relevant DNA methylation changes". Clinical Epigenetics 13 1 (2021): http://dx.doi.org/10.1186/s13148-021-01144-z.
    10.1186/s13148-021-01144-z
  6. "Single-cell RNA-seq unravels alterations of the human spermatogonial stem cell compartment in patients with impaired spermatogenesis". Cell Reports Medicine (2021): 100395-100395. http://dx.doi.org/10.1016/j.xcrm.2021.100395.
    10.1016/j.xcrm.2021.100395
  7. "Healthy ageing and spermatogenesis.". Reproduction (Cambridge, England) (2021): https://doi.org/10.1530/REP-20-0633.
    10.1530/rep-20-0633
  8. Laurentino, Sandra. "The role of gonadotropins in testicular and adrenal androgen biosynthesis pathways-Insights from males with congenital hypogonadotropic hypogonadism on hCG/rFSH and on testosterone replacement". Clinical endocrinology (2021): https://doi.org/10.1111/cen.14324.
    10.1111/cen.14324
  9. Sandra Laurentino; Jann-Frederik Cremers; Bernhard Horsthemke; Frank Tüttelmann; Karen Czeloth; Michael Zitzmann; Eva Pohl; et al. "A germ cell-specific ageing pattern in otherwise healthy men". Aging Cell 19 10 (2020): https://doi.org/10.1111/acel.13242.
    10.1111/acel.13242
  10. Elsa Leitão; Sara Di Persio; Sandra Laurentino; Marius Wöste; Martin Dugas; Sabine Kliesch; Nina Neuhaus; Bernhard Horsthemke. "The sperm epigenome does not display recurrent epimutations in patients with severely impaired spermatogenesis". Clinical Epigenetics 12 1 (2020): https://doi.org/10.1186%2Fs13148-020-00854-0.
    10.1186/s13148-020-00854-0
  11. Marius Wöste; Elsa Leitão; Sandra Laurentino; Bernhard Horsthemke; Sven Rahmann; Christopher Schröder. "wg-blimp: an end-to-end analysis pipeline for whole genome bisulfite sequencing data". BMC Bioinformatics 21 1 (2020): https://doi.org/10.1186%2Fs12859-020-3470-5.
    10.1186/s12859-020-3470-5
  12. Laurentino, Sandra. "Molecular Aging Markers in Patients with Klinefelter Syndrome". Aging and disease (2020): https://europepmc.org/articles/PMC7220296.
    10.14336/ad.2019.0801
  13. Laurentino, Sandra. "High-resolution analysis of germ cells from men with sex chromosomal aneuploidies reveals normal transcriptome but impaired imprinting". Clinical Epigenetics (2019): http://dx.doi.org/10.1186/s13148-019-0720-3.
    10.1186/s13148-019-0720-3
  14. Daniel Langenstroth-Röwer; Jörg Gromoll; Joachim Wistuba; Ina Tröndle; Sandra Laurentino; Stefan Schlatt; Nina Neuhaus. "De novo methylation in male germ cells of the common marmoset monkey occurs during postnatal development and is maintained in vitro". Epigenetics (2016): 0-0. http://dx.doi.org/10.1080/15592294.2016.1248007.
    10.1080/15592294.2016.1248007
  15. Jennifer Borgmann; Frank Tüttelmann; Bernd Dworniczak; Albrecht Röpke; Hye-Won Song; Sabine Kliesch; Miles F. Wilkinson; Sandra Laurentino; Jörg Gromoll. "The human RHOX gene cluster: target genes and functional analysis of gene variants in infertile men". Human Molecular Genetics (2016): ddw313-ddw313. http://dx.doi.org/10.1093/hmg/ddw313.
    10.1093/hmg/ddw313
  16. Laurentino SS; Borgmann J; Gromoll J. "On the origin of sperm epigenetic heterogeneity.". (2016): http://europepmc.org/abstract/med/26884419.
  17. Laurentino, S.; Borgmann, J.; Gromoll, J.. "On the origin of sperm epigenetic heterogeneity". Reproduction 151 5 (2016): R71-R78. http://www.scopus.com/inward/record.url?eid=2-s2.0-84968756377&partnerID=MN8TOARS.
    10.1530/REP-15-0436
  18. Laurentino, S.; Beygo, J.; Nordhoff, V.; Kliesch, S.; Wistuba, J.; Borgmann, J.; Buiting, K.; Horsthemke, B.; Gromoll, J.. "Epigenetic germline mosaicism in infertile men". Human Molecular Genetics 24 5 (2015): 1295-1304. http://www.scopus.com/inward/record.url?eid=2-s2.0-84924463066&partnerID=MN8TOARS.
    10.1093/hmg/ddu540
  19. Laurentino, S.S.; Pinto, P.I.S.; Tomás, J.; Cavaco, J.E.; Sousa, M.; Barros, A.; Power, D.M.; Canário, A.V.M.; Socorro, S.. "Identification of androgen receptor variants in testis from humans and other vertebrates". Andrologia 45 3 (2013): 187-194. http://www.scopus.com/inward/record.url?eid=2-s2.0-84876814362&partnerID=MN8TOARS.
    10.1111/j.1439-0272.2012.01333.x
  20. Laurentino, S.S.; Correia, S.; Cavaco, J.E.; Oliveira, P.F.; de Sousa, M.D.; Barros, A.; Socorro, S.. "Regucalcin, a calcium-binding protein with a role in male reproduction?". Molecular Human Reproduction 18 4 (2012): 161-170. http://www.scopus.com/inward/record.url?eid=2-s2.0-84858685367&partnerID=MN8TOARS.
    10.1093/molehr/gar075
  21. Oliveira, P.F.; Alves, M.G.; Rato, L.; Laurentino, S.; Silva, J.; Sá, R.; Barros, A.; et al. "Effect of insulin deprivation on metabolism and metabolism-associated gene transcript levels of in vitro cultured human Sertoli cells". Biochimica et Biophysica Acta - General Subjects 1820 2 (2012): 84-89. http://www.scopus.com/inward/record.url?eid=2-s2.0-83455235851&partnerID=MN8TOARS.
    10.1016/j.bbagen.2011.11.006
  22. Laurentino, S.S.; Correia, S.; Cavaco, J.E.; Oliveira, P.F.; Rato, L.; Sousa, M.; Barros, A.; Socorro, S.. "Regucalcin is broadly expressed in male reproductive tissues and is a new androgen-target gene in mammalian testis". Reproduction 142 3 (2011): 447-456. http://www.scopus.com/inward/record.url?eid=2-s2.0-80051992405&partnerID=MN8TOARS.
    10.1530/REP-11-0085
  23. Laurentino, S.; Gonalves, J.; Cavaco, J.E.; Oliveira, P.F.; Alves, M.G.; De Sousa, M.; Barros, A.; Socorro, S.. "Apoptosis-inhibitor Aven is downregulated in defective spermatogenesis and a novel estrogen target gene in mammalian testis". Fertility and Sterility 96 3 (2011): 745-750. http://www.scopus.com/inward/record.url?eid=2-s2.0-80052262541&partnerID=MN8TOARS.
    10.1016/j.fertnstert.2011.06.009
  24. Cavaco, J.E.B.; Laurentino, S.S.; Barros, A.; Sousa, M.; Socorro, S.. "Estrogen receptors a and ß in human testis: Both isoforms are expressed". Systems Biology in Reproductive Medicine 55 4 (2009): 137-144. http://www.scopus.com/inward/record.url?eid=2-s2.0-72949111982&partnerID=MN8TOARS.
    10.3109/19396360902855733
Livro
  1. Cavaco, J.E.; Laurentino, S.; Correia, S.; Pinto, P.; Socorro, S.. Naturally occurring androgen receptor splice variants: Impact on androgen signaling pathways. 2014.
Tese / Dissertação
  1. Laurentino, Sandra Filipa Tomás Sequeira. "Sexual steroid regulation of spermatogenesis: new actors enter the stage". Doutoramento, 2011. http://hdl.handle.net/10400.6/942.
  2. Laurentino, Sandra Filipa Tomás Sequeira. "Sexual steroid regulation of spermatogenesis: new actors enter the stage". Doutoramento, 2011. http://hdl.handle.net/10400.6/942.

Outros

Outra produção
  1. Balancing the scales: the interplay of diet, exercise, GLP-1 receptor agonists, and obesity in shaping male reproductive health. 2023. Omar Ammar; Juan Fraire-Zamora; Georgios Liperis; Zoya Ali; Munevver Serdarogullari; Sandra Laurentino; Adam Watkins; et al. https://doi.org/10.1093/humrep/dead126.
    10.1093/humrep/dead126
  2. Stage-specific gene and transcript dynamics in human male germ cells. 2022. Siebert-Kuss, L.M.; Krenz, H.; Tekath, T.; Wöste, M.; Persio, S.D.; Terwort, N.; Wyrwoll, M.J.; et al. http://www.scopus.com/inward/record.url?eid=2-s2.0-85128574400&partnerID=MN8TOARS.
    10.1101/2022.03.22.485121
  3. EGR4-dependent decrease of UTF1 is associated with failure to reserve spermatogonial stem cells in infertile men. 2021. Laurentino, Sandra. https://doi.org/10.1101/2021.02.02.429371.
    10.1101/2021.02.02.429371
  4. The sperm epigenome does not display recurrent epimutations in patients with severely impaired spermatogenesis. 2020. Elsa Leitão; Sara Di Persio; Sandra Laurentino; Marius Wöste; Martin Dugas; Sabine Kliesch; Nina Neuhaus; Bernhard Horsthemke. https://doi.org/10.1101/2020.02.10.941724.
    10.1101/2020.02.10.941724
  5. wg-blimp: an end-to-end analysis pipeline for whole genome bisulfite sequencing data. 2019. Marius Wöste; Elsa Leitão; Sandra Laurentino; Bernhard Horsthemke; Sven Rahmann; Christopher Schröder. https://doi.org/10.1101/859900.
    10.1101/859900
  6. Healthy ageing men have normal reproductive function but display germline-specific molecular changes. 2019. S. Laurentino; J.-F. Cremers; B. Horsthemke; F. Tüttelmann; K. Czeloth; M. Zitzmann; E. Pohl; et al. https://doi.org/10.1101/19006221.
    10.1101/19006221