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Mariana Pina Lince de Faria is graduted in Genetics and Microbiology by Lisbon University and has a PhD in Genetics by Lisbon University. Principal Investigator of an Exploratory Project financed by Fundação Para a Ciência e Tecnologia in 2014/2015 (EXPL_BIM_ONC_0830_2013). Lab Manager and Research Scientist in Instituto Gulbenkian Ciencia / Gulbenkian Institute for Molecular Medicine). Research Interests focused in Cell Biology, Centrosome Biogenesis, Cell Cycle and Mitosis. Experience working with different biological systems such as fruit fly (Drosophila melanogaster), mouse (mus muscullus) and tissue culture of cells from different origins. Multiple years of expertise in Molecular Biology and Biochemistry techniques as well as in state of the art microscopy and improving sample quality for better imaging. Proven history of optimizing and maintaining organized and accessible lab areas in alignment with good laboratory functioning and a friendly working environment.
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Identificação

Identificação pessoal

Nome completo
Mariana Pina Lince de Faria

Nomes de citação

  • Lince-Faria, Mariana

Identificadores de autor

Ciência ID
E31C-7DEF-884F
ORCID iD
0000-0002-9842-173X
Formação
Grau Classificação
2006
Concluído
 Genética (Doutoramento)
Universidade de Lisboa Faculdade de Ciências, Portugal
"Caracterização de mutantes mitóticos em Drosophila melanogaster" (TESE/DISSERTAÇÃO)
 Distinção e Louvor por unanimidade
2000
Concluído
 Biologia Microbiana e Genética (Licenciatura)
Universidade de Lisboa Faculdade de Ciências, Portugal
"Caracterização de mutantes mitóticos em Drosophila melanogaster" (TESE/DISSERTAÇÃO)
 16
Percurso profissional

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2018/10/01 - Atual Lab Manager Fundação Calouste Gulbenkian, Portugal
2013/07/03 - 2018/09/30 Senior Pos Doctoral fellow/Lab Manager Instituto Gulbenkian de Ciência, Portugal
2012/04/01 - 2013/07/02 Senior pos-Doctoral Fellow from European Research Council Instituto Gulbenkian de Ciência, Portugal
2009/10/01 - 2012/03/31 Senior Post-Doctoral Fellow from Shlumberger Foundation Instituto Gulbenkian de Ciência, Portugal
2006/10/02 - 2009/09/30 Post-doctoral fellow from FCT Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2001/09/03 - 2005/09/30 phD student financed by FCT Instituto Gulbenkian de Ciência, Portugal
2000/09/01 - 2001/07/31 fellow from Instituto de Emprego e Formação Profissional/Fundação Gulbenkian Instituto Gulbenkian de Ciência, Portugal
1999/09/01 - 2000/07/31 Trainee Instituto Gulbenkian de Ciência, Portugal
Projetos

Projeto

Designação Financiadores
2017/01/01 - 2021/12/31 Mechanism of centriole inheritance and maintenance
info:eu-repo/grantAgreement/EC/H2020/683258/EU
Investigador
Instituto Gulbenkian de Ciência, Portugal
 European Commission
Em curso
2017/07/01 - 2019/12/31 Length matters: causes and consequences of centriole length deregulation in cancer
PTDC/BIM-ONC/6858/2014
Investigador
Instituto Gulbenkian de Ciência, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2014/02/03 - 2015/08/02 Novel approaches to study the control of centrosome number
EXPL/BIM-ONC/0830/2013
Investigador responsável
Instituto Gulbenkian de Ciência, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2011/04/01 - 2013/07/31 Microtubule Regulation in Centriole Biogenesis Mechanisms
info:eu-repo/grantAgreement/FCT/3599-PPCDT/112736/PT
Investigador
Instituto Gulbenkian de Ciência, Portugal
 European Commission
Concluído

Outro

Designação Financiadores
2022/01/15 - Atual Regulation of de Novo Centriole Biogenesis by the Actin Network
PTDC/BIA-CEL/4202/2021
Co-Investigador Responsável (Co-IR)
Instituto Gulbenkian de Ciência, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
Produções

Publicações

Artigo em revista
  1. Ana Pimenta-Marques; Tania Perestrelo; Patricia Reis-Rodrigues; Paulo Duarte; Ana Ferreira-Silva; Mariana Lince-Faria; Mónica Bettencourt-Dias. "Ana1/CEP295 is an essential player in the centrosome maintenance program regulated by Polo kinase and the PCM". EMBO Reports (2024): https://doi.org/10.1038/s44319-023-00020-6.
    10.1038/s44319-023-00020-6
  2. Magistrati, Elisa; Maestrini, Giorgia; Niño, Carlos A; Lince-Faria, Mariana; Beznoussenko, Galina; Mironov, Alexandre; Maspero, Elena; Bettencourt-Dias, Mónica; Polo, Simona. "Myosin VI regulates ciliogenesis by promoting the turnover of the centrosomal/satellite protein OFD1". EMBO reports 23 3 (2021): http://dx.doi.org/10.15252/embr.202154160.
    10.15252/embr.202154160
  3. Gurkaslar, H. Kubra; Culfa, Efraim; Arslanhan, Melis D.; Lince-Faria, Mariana; Firat-Karalar, Elif Nur. "CCDC57 Cooperates with Microtubules and Microcephaly Protein CEP63 and Regulates Centriole Duplication and Mitotic Progression". Cell Reports 31 6 (2020): 107630. http://dx.doi.org/10.1016/j.celrep.2020.107630.
    10.1016/j.celrep.2020.107630
  4. Zitouni, Sihem; Francia, Maria E.; Leal, Filipe; Montenegro Gouveia, Susana; Nabais, Catarina; Duarte, Paulo; Gilberto, Samuel; et al. "CDK1 Prevents Unscheduled PLK4-STIL Complex Assembly in Centriole Biogenesis". (2016): http://hdl.handle.net/10400.7/831.
    10.1016/j.cub.2016.03.055
  5. Lopes, Carla A.M.; Jana, Swadhin Chandra; Cunha-Ferreira, Inês; Zitouni, Sihem; Bento, Inês; Duarte, Paulo; Gilberto, Samuel; et al. "PLK4 trans-Autoactivation Controls Centriole Biogenesis in Space". (2015): http://hdl.handle.net/10400.7/830.
    10.1016/j.devcel.2015.09.020
  6. Cunha-Ferreira, Inês; Bento, Inês; Pimenta-Marques, Ana; Jana, Swadhin Chandra; Lince-Faria, Mariana; Duarte, Paulo; Borrego-Pinto, Joana; et al. "Regulation of Autophosphorylation Controls PLK4 Self-Destruction and Centriole Number". (2013): http://hdl.handle.net/10400.7/833.
    10.1016/j.cub.2013.09.037
  7. Jiang, K.; Toedt, G.; Montenegro Gouveia, S.; Davey, N.E.; Hua, S.; Van Der Vaart, B.; Grigoriev, I.; et al. "A proteome-wide screen for mammalian SxIP motif-containing microtubule plus-end tracking proteins". Current Biology 22 19 (2012): 1800-1807. http://www.scopus.com/inward/record.url?eid=2-s2.0-84867402137&partnerID=MN8TOARS.
    Publicado • 10.1016/j.cub.2012.07.047
  8. Holland, A.J.; Fachinetti, D.; Da Cruz, S.; Zhu, Q.; Vitre, B.; Lince-Faria, M.; Chen, D.; et al. "Polo-like kinase 4 controls centriole duplication but does not directly regulate cytokinesis". Molecular Biology of the Cell 23 10 (2012): 1838-1845. http://www.scopus.com/inward/record.url?eid=2-s2.0-84861163747&partnerID=MN8TOARS.
    10.1091/mbc.E11-12-1043
  9. Maiato, Helder; Lince-Faria, Mariana. "The perpetual movements of anaphase". Cellular and Molecular Life Sciences 67 13 (2010): 2251-2269. http://dx.doi.org/10.1007/s00018-010-0327-5.
    10.1007/s00018-010-0327-5
  10. Ding, Yun; Yao, Changfu; Lince-Faria, Mariana; Rath, Uttama; Cai, Weili; Maiato, Helder; Girton, Jack; Johansen, Kristen M.; Johansen, Jørgen. "Chromator is required for proper microtubule spindle formation and mitosis in Drosophila". Developmental Biology 334 1 (2009): 253-263. http://dx.doi.org/10.1016/j.ydbio.2009.07.027.
    10.1016/j.ydbio.2009.07.027
  11. Matos, Irina; Pereira, António J.; Lince-Faria, Mariana; Cameron, Lisa A.; Salmon, Edward D.; Maiato, Helder. "Synchronizing chromosome segregation by flux-dependent force equalization at kinetochores". Journal of Cell Biology 186 1 (2009): 11-26. http://dx.doi.org/10.1083/jcb.200904153.
    10.1083/jcb.200904153
  12. Lince-Faria, Mariana; Maffini, Stefano; Orr, Bernard; Ding, Yun; Florindo, Cláudia; Sunkel, Claudio E.; Tavares, Álvaro; et al. "Spatiotemporal control of mitosis by the conserved spindle matrix protein Megator". Journal of Cell Biology 184 5 (2009): 647-657. http://dx.doi.org/10.1083/jcb.200811012.
    10.1083/jcb.200811012
  13. Pereira, Ana L.; Pereira, António J.; Maia, Ana R.R.; Drabek, Ksenija; Sayas, C. Laura; Hergert, Polla J.; Lince-Faria, Mariana; et al. "Mammalian CLASP1 and CLASP2 Cooperate to Ensure Mitotic Fidelity by Regulating Spindle and Kinetochore Function". Molecular Biology of the Cell 17 10 (2006): 4526-4542. http://dx.doi.org/10.1091/mbc.e06-07-0579.
    10.1091/mbc.e06-07-0579
Capítulo de livro
  1. Pereira, António J.; Matos, Irina; Lince-Faria, Mariana; Maiato, Helder. "Dissecting Mitosis with Laser Microsurgery and RNAi in Drosophila Cells". In Methods in Molecular Biology, 145-164. Humana Press, 2009.
    10.1007/978-1-60327-993-2_9
Tese / Dissertação
  1. Lince-Faria, Mariana. "Caracterização de mutantes mitóticos em Drosphila melanogaster". Doutoramento, Universidade de Lisboa Faculdade de Ciências, 2006.
Atividades

Participação em evento

Descrição da atividade
Tipo de evento 		Nome do evento
Instituição / Organização
2019 - 2019 Expansion Microscopy Workshop, Geneve, Switzerland. Theoretical and practical learning on the UExM technique, other variants of Expansion Microscopy and their possible applications.
Oficina (workshop)
 Expansion Microscopy Workshop
Universite de Geneve, Suiça
2018/03 - 2018/03 OMX user meeting
Oficina (workshop)
 OMX user meeting
GE Healthcare Europe GmbH, Alemanha
2018 - 2018 Edinburgh Super-Resolution Imaging Consortium (ESRIC) Summer School -Single Molecule Localization Microscopy, Structured Illumination Microscopy, Stimulated Emission Depletion Microscopy, Airyscan detector and respective practical sessions. Being the person responsible for a Structured Illumination Microscope in our Institute, this course gave me a broader view of all the Super-resolution techniques developed, as well as a deeper understanding of the SIM technique itself.
Oficina (workshop)
 ESRIC Summer School
Edinburgh Super-Resolution Imaging Consortium, Reino Unido
2009 - 2009 PDE (Program Toward Business) - Trade Policy and Marketing, Finance, Human Behavior in Organization and Ethics, Operations and Technology, Social and Economic Analysis for Management, Accounting and Management Control Systems
Oficina (workshop)
 Programa de Direção Empresarial
AESE Business School, Portugal
2002/06 - 2002/06 Practical Course of Life Specimen Light Microscopy - learning and practicing the State of the art techniques on light Microscopy with both living and fixed cells. This course gave me the necessary basic concepts and principals of light properties and its usage in microscopy, which became for me an essential tool as a microscopist.
Oficina (workshop)
 Practical Course of Life Specimen Light Microscopy
European Molecular Biology Laboratory, Alemanha

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2019 - 2019 Inspirar Ciência - Genética (Pós-Graduação) Instituto Gulbenkian de Ciência, Portugal

Outro júri / avaliação

Descrição da atividade Instituição / Organização
2015 - 2015 member of FCT evaluation panel for PhD fellowships in Biological Sciences Fundação para a Ciência e a Tecnologia, Portugal
Distinções

Outra distinção

2014 EMBO short term fellowship
European Molecular Biology Laboratory, Alemanha