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Identificação

Identificação pessoal

Nome completo
Carlos Miguel Ribeiro da Silva Farinha

Nomes de citação

  • Carlos Farinha
  • Carlos M. Farinha

Identificadores de autor

Ciência ID
DC12-585B-127E
ORCID iD
0000-0002-5467-1710
Google Scholar ID
https://scholar.google.com/citations?view_op=list_works&hl=en&user=73tzDooAAAAJ&gmla=AJsN-F5yX4ewlTpNYaKl_fp1yDwe_dVHia7IkGqVb8Opvax68eylv_ybr9dETcZJvVDxfWhwxus_W7AJN7iWKY5dP4dggdLogenPRHxoRPGSV9WDtr9Phlw
Scopus Author Id
6603173042

Endereços de correio eletrónico

  • cmfarinha@fc.ul.pt (Profissional)

Moradas

  • Faculdade de Ciências, BioISI - Instituto de Biossistemas e Ciências Integrativas. Campo Grande, Edifício C8, 1749-016, Lisboa, Lisboa, Portugal (Profissional)

Websites

Formação
Grau Classificação
2015/06
Concluído
 Bioquímica (Título de Agregado)
Universidade de Lisboa Faculdade de Ciências, Portugal
1997 - 2003
Concluído
 Bioquímica (Doutoramento)
Universidade de Lisboa, Portugal
"Processing and Intracellular Trafficking of Wild-type and Mutant CFTR" (TESE/DISSERTAÇÃO)
 Aprovado c/ distinção e louvor
1995
Concluído
 Bioquímica (Licenciatura)
Universidade de Lisboa Faculdade de Ciências, Portugal
"Estudos de Expressão do Gene CFTR associado à Fibrose Quística" (TESE/DISSERTAÇÃO)
 18/20
Percurso profissional

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2020/09/08 - Atual Professor Associado (Docente Universitário) Universidade de Lisboa Faculdade de Ciências, Portugal
2008/11 - 2020 Professor Auxiliar (Docente Universitário) Universidade de Lisboa, Portugal
2003/12/01 - 2008/09/30 Professor Auxiliar Convidado (Docente Universitário) Universidade de Lisboa Faculdade de Ciências, Portugal
2001/09 - 2003/11 Assistente Estagiário (Docente Universitário) Universidade de Lisboa, Portugal

Cargos e Funções

Categoria Profissional
Instituição de acolhimento 		Empregador
2017 - Atual Conselho geral ou orgão correspondente Universidade de Lisboa, Portugal

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2023/07 - Atual Coordinator of Biochemistry PhD degree Universidade de Lisboa Faculdade de Ciências, Portugal
2014/12/31 - Atual Principal Investigator - Member Universidade de Lisboa Instituto de Biossistemas e Ciências Integrativas, Portugal
2017 - 2023/07 Deputy Coordinator of Biochemistry PhD degree Universidade de Lisboa Faculdade de Ciências, Portugal
2015/04/01 - 2015/11/01 Visiting Research Scholar University of Pittsburgh School of Medicine, Estados Unidos
2008/01/01 - 2014/12/31 Post-doctoral Senior Fellow/Principal Investigator - Member Universidade de Lisboa Centro para a Biodiversidade, Genómica Integrativa e Funcional (BioFIG), Portugal
2003/02/07 - 2007/12/31 Post-Doctoral Research Fellow Instituto Nacional de Saúde Doutor Ricardo Jorge IP, Portugal
2005/03/01 - 2007/02/28 Deputy Coordinator of Biochemistry BSc/MSc degree Universidade de Lisboa Faculdade de Ciências, Portugal
1997/05/01 - 2003/02/07 Graduate (PhD) student Instituto Nacional de Saúde Doutor Ricardo Jorge IP, Portugal
1997/10/15 - 1997/12/15 Visiting graduate student Johns Hopkins University School of Medicine, Estados Unidos
1996/03/01 - 1997/04/30 Training research assistant (BI Fellowship recipient) Instituto Nacional de Saúde Doutor Ricardo Jorge IP, Portugal
1995/04/01 - 1995/12/31 Training research Assistant (young researcher fellowship recipient) Instituto Nacional de Saúde Doutor Ricardo Jorge IP, Portugal
1994/10/01 - 1995/07/28 Undergraduate student Instituto Nacional de Saúde Doutor Ricardo Jorge IP, Portugal
Produções

Publicações

Artigo em conferência
  1. Ferreira, V.F.C; Oliveira, B.L.; Correia, J.D.G.; Santos, I.; Farinha, Carlos Miguel Ribeiro da Silva; Mendes, Filipa. "Cystic Fibrosis: new molecular imaging tools". Trabalho apresentado em EuroBIC 12 - 12th European Biological Inorganic Chemistry Conference, Zurich, 2014.
    Publicado
Artigo em revista
  1. Rodrigues, Cláudia S; Railean, Violeta; Ramalho, Sofia S; Farinha, Carlos M; Pankonien, Ines; Amaral, Margarida D. "Personalized therapy with CFTR modulators: Response of p.Ile148Asn variant". Journal of Cystic Fibrosis (2025): https://doi.org/10.1016/j.jcf.2025.01.015.
    Publicado • 10.1016/j.jcf.2025.01.015
  2. Cruz, Daniel F.; Donovan, Joshua; Hejenkowska, Ewelina D.; Mu, Fangping; Banerjee, Ipsita; Köhn, Maja; Farinha, Carlos M.; Swiatecka-Urban, Agnieszka. "LMTK2 switches on canonical TGF-ß1 signaling in human bronchial epithelial cells". American Journal of Physiology-Lung Cellular and Molecular Physiology 327 5 (2024): L769-L782. https://doi.org/10.1152/ajplung.00034.2024.
    Publicado • 10.1152/ajplung.00034.2024
  3. Smith, C.; Chadwick, H.K.; Hill, K.; Peckham, D.G.. "E-learning within the European cystic fibrosis society - A multidisciplinary cross-sectional survey". Journal of Cystic Fibrosis 23 5 (2024): 1020-1023. https://doi.org/10.1016/j.jcf.2024.07.003.
    Publicado • 10.1016/j.jcf.2024.07.003
  4. Farinha, Carlos M.. "Disrupting the TGF-ß–Wnt Balance to Control the Polarity of the Cystic Fibrosis Airway Epithelium". American Journal of Respiratory Cell and Molecular Biology 71 1 (2024): 16-17. https://doi.org/10.1165/rcmb.2024-0112ed.
    Publicado • 10.1165/rcmb.2024-0112ed
  5. Carlos M. Farinha; Lúcia Santos; João Ferreira. "Cell type-specific regulation of CFTR trafficking - on the verge of progress". Frontiers in Cell and Developmental Biology (2024): http://dx.doi.org/10.3389/fcell.2024.1338892.
    10.3389/fcell.2024.1338892
  6. Mention, Karen; Cavusoglu-Doran, Kader; Joynt, Anya T; Santos, Lúcia; Sanz, David; Eastman, Alice C; Merlo, Christian; et al. "Use of adenine base editing and homology-independent targeted integration strategies to correct the cystic fibrosis causing variant, W1282X". Human Molecular Genetics 32 23 (2023): 3237-3248. http://dx.doi.org/10.1093/hmg/ddad143.
    10.1093/hmg/ddad143
  7. Railean, Violeta; Rodrigues, Cláudia S.; Ramalho, Sofia S.; Silva, Iris A. L.; Bartosch, Jan; Farinha, Carlos M.; Pankonien, Ines; Amaral, Margarida D.. "Personalized medicine: Function of CFTR variant p.Arg334Trp is rescued by currently available CFTR modulators". Frontiers in Molecular Biosciences 10 (2023): http://dx.doi.org/10.3389/fmolb.2023.1155705.
    10.3389/fmolb.2023.1155705
  8. Farinha, Carlos M.; Brodsky, Jeffrey L.; Pedemonte, Nicoletta. "Fundamental and translational research in Cystic Fibrosis – why we still need it". Journal of Cystic Fibrosis 22 (2023): S1-S4. http://dx.doi.org/10.1016/j.jcf.2022.12.010.
    10.1016/j.jcf.2022.12.010
  9. Santos, Lúcia; Nascimento, Rui; Duarte, Aires; Railean, Violeta; Amaral, Margarida D.; Harrison, Patrick T.; Gama-Carvalho, Margarida; Farinha, Carlos M.. "Mutation-class dependent signatures outweigh disease-associated processes in cystic fibrosis cells". Cell & Bioscience 13 1 (2023): http://dx.doi.org/10.1186/s13578-023-00975-y.
    10.1186/s13578-023-00975-y
  10. Zacarias, Sónia; Batista, Marta S. P.; Ramalho, Sofia S.; Victor, Bruno L.; Farinha, Carlos M.. "Rescue of Rare CFTR Trafficking Mutants Highlights a Structural Location-Dependent Pattern for Correction". International Journal of Molecular Sciences 24 4 (2023): 3211. http://dx.doi.org/10.3390/ijms24043211.
    10.3390/ijms24043211
  11. João F. Ferreira; Iris A. L. Silva; Hugo M. Botelho; Margarida D. Amaral; Carlos M. Farinha. "Absence of EPAC1 Signaling to Stabilize CFTR in Intestinal Organoids". Cells (2022): https://doi.org/10.3390/cells11152295.
    10.3390/cells11152295
  12. Farinha, Carlos M.; Callebaut, Isabelle. "Molecular mechanisms of cystic fibrosis – how mutations lead to misfunction and guide therapy". Bioscience Reports 42 7 (2022): https://doi.org/10.1042/bsr20212006.
    Publicado • 10.1042/bsr20212006
  13. Cuyx, Senne; Ramalho, Sofia S.; Callebaut, Isabelle; Cuppens, Harry; Kmit, Arthur; Arnauts, Kaline; Ferrante, Marc; et al. "Severity of the S1251N allele in cystic fibrosis is affected by the presence of the F508C variant in cis". Journal of Cystic Fibrosis 21 4 (2022): 644-651. https://doi.org/10.1016/j.jcf.2022.05.013.
    Publicado • 10.1016/j.jcf.2022.05.013
  14. Lopes-Pacheco, Miquéias; Bacalhau, Mafalda; Ramalho, Sofia S.; Silva, Iris A. L.; Ferreira, Filipa C.; Carlile, Graeme W.; Thomas, David Y.; et al. "Rescue of Mutant CFTR Trafficking Defect by the Investigational Compound MCG1516A". Cells 11 1 (2022): 136. http://dx.doi.org/10.3390/cells11010136.
    10.3390/cells11010136
  15. Santos, Lúcia; Mention, Karen; Cavusoglu-Doran, Kader; Sanz, David J.; Bacalhau, Mafalda; Lopes-Pacheco, Miquéias; Harrison, Patrick T; Farinha, Carlos M. "Comparison of Cas9 and Cas12a CRISPR editing methods to correct the W1282X-CFTR mutation". Journal of Cystic Fibrosis 21 1 (2022): 181-187. https://doi.org/10.1016/j.jcf.2021.05.014.
    Publicado • 10.1016/j.jcf.2021.05.014
  16. Ramalho, Sofia S.; Silva, Iris A. L.; Amaral, Margarida D.; Farinha, Carlos M.. "Rare Trafficking CFTR Mutations Involve Distinct Cellular Retention Machineries and Require Different Rescuing Strategies". International Journal of Molecular Sciences 23 1 (2021): 24. https://doi.org/10.3390/ijms23010024.
    10.3390/ijms23010024
  17. Farinha, Carlos M.; Gentzsch, Martina. "Revisiting CFTR Interactions: Old Partners and New Players". International Journal of Molecular Sciences 22 24 (2021): 13196. http://dx.doi.org/10.3390/ijms222413196.
    10.3390/ijms222413196
  18. Clarke, Luka A.; Luz, Vanessa C. C.; Targowski, Szymon; Ramalho, Sofia S.; Farinha, Carlos M.; Amaral, Margarida D.. "Integrity and Stability of PTC Bearing CFTR mRNA and Relevance to Future Modulator Therapies in Cystic Fibrosis". Genes 12 11 (2021): 1810. http://dx.doi.org/10.3390/genes12111810.
    10.3390/genes12111810
  19. Pereira, Catarina; Mazein, Alexander; Farinha, Carlos M.; Gray, Michael A.; Kunzelmann, Karl; Ostaszewski, Marek; Balaur, Irina; Amaral, Margarida D.; Falcao, Andre O.. "CyFi-MAP: an interactive pathway-based resource for cystic fibrosis". Scientific Reports 11 1 (2021): http://dx.doi.org/10.1038/s41598-021-01618-3.
    10.1038/s41598-021-01618-3
  20. Cruz, Daniel F.; Mitash, Nilay; Mu, Fangping; Farinha, Carlos M.; Swiatecka-Urban, Agnieszka. "Differential Gene Expression Analysis Reveals Global LMTK2 Regulatory Network and Its Role in TGF-ß1 Signaling". Frontiers in Oncology 11 (2021): http://dx.doi.org/10.3389/fonc.2021.596861.
    10.3389/fonc.2021.596861
  21. Ferreira, Vera F. C.; Oliveira, Bruno L.; D’Onofrio, Alice; Farinha, Carlos M.; Gano, Lurdes; Paulo, António; Bernardes, Gonçalo J. L.; Mendes, Filipa. "In Vivo Pretargeting Based on Cysteine-Selective Antibody Modification with IEDDA Bioorthogonal Handles for Click Chemistry". Bioconjugate Chemistry 32 1 (2020): 121-132. http://dx.doi.org/10.1021/acs.bioconjchem.0c00551.
    10.1021/acs.bioconjchem.0c00551
  22. Silva, Iris A.L.; Doušová, Tereza; Ramalho, Sofia; Centeio, Raquel; Clarke, Luka A.; Railean, Violeta; Botelho, Hugo M.; et al. "Organoids as a personalized medicine tool for ultra-rare mutations in cystic fibrosis: The case of S955P and 1717-2A>G". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1866 11 (2020): 165905. http://dx.doi.org/10.1016/j.bbadis.2020.165905.
    10.1016/j.bbadis.2020.165905
  23. Farinha, Carlos M.. "From disease mechanisms to novel therapies and back". Journal of Cystic Fibrosis 19 5 (2020): 673-674. http://dx.doi.org/10.1016/j.jcf.2020.06.014.
    10.1016/j.jcf.2020.06.014
  24. Santos, João D.; Pinto, Francisco R.; Ferreira, João F.; Amaral, Margarida D.; Zaccolo, Manuela; Farinha, Carlos M.. "Cytoskeleton regulators CAPZA2 and INF2 associate with CFTR to control its plasma membrane levels under EPAC1 activation". Biochemical Journal 477 13 (2020): 2561-2580. http://dx.doi.org/10.1042/bcj20200287.
    10.1042/bcj20200287
  25. Uliyakina, Inna; Botelho, Hugo M.; da Paula, Ana C.; Afonso, Sara; Lobo, Miguel J.; Felício, Verónica; Farinha, Carlos M.; Amaral, Margarida D.. "Full Rescue of F508del-CFTR Processing and Function by CFTR Modulators Can Be Achieved by Removal of Two Regulatory Regions". International Journal of Molecular Sciences 21 12 (2020): 4524. http://dx.doi.org/10.3390/ijms21124524.
    10.3390/ijms21124524
  26. Ferreira, Vera F.C.; Correia, João D.G.; Farinha, Carlos M.; Mendes, Filipa. "Improved Fmoc-solid-phase peptide synthesis of an extracellular loop of CFTR for antibody selection by the phage display technology". Journal of Peptide Science 26 7 (2020): http://dx.doi.org/10.1002/psc.3253.
    10.1002/psc.3253
  27. Carapeto, Ana P.; Vitorino, Miguel V.; Santos, João D.; Ramalho, Sofia S.; Robalo, Tiago; Rodrigues, Mário S.; Farinha, Carlos M.. "Mechanical Properties of Human Bronchial Epithelial Cells Expressing Wt- and Mutant CFTR". International Journal of Molecular Sciences 21 8 (2020): 2916. http://dx.doi.org/10.3390/ijms21082916.
    10.3390/ijms21082916
  28. Cottrill, Kirsten A.; Farinha, Carlos M.; McCarty, Nael A.. "The bidirectional relationship between CFTR and lipids". Communications Biology 3 1 (2020): http://dx.doi.org/10.1038/s42003-020-0909-1.
    10.1038/s42003-020-0909-1
  29. Cruz, Daniel F.; Mitash, Nilay; Farinha, Carlos M.; Swiatecka-Urban, Agnieszka. "TGF-ß1 Augments the Apical Membrane Abundance of Lemur Tyrosine Kinase 2 to Inhibit CFTR-Mediated Chloride Transport in Human Bronchial Epithelia". Frontiers in Cell and Developmental Biology 8 (2020): http://dx.doi.org/10.3389/fcell.2020.00058.
    10.3389/fcell.2020.00058
  30. Callebaut, Isabelle; Mense, Martin; Farinha, Carlos M.. "Exploring the basic mechanisms in Cystic Fibrosis: Promoting data presentation and discussion at the 16th ECFS Basic Science Conference". Journal of Cystic Fibrosis (2020): http://dx.doi.org/10.1016/j.jcf.2019.12.013.
    10.1016/j.jcf.2019.12.013
  31. Farinha, Carlos M.. "Omics in CF – Where are we now?". Journal of Cystic Fibrosis 18 4 (2019): 443-444. http://dx.doi.org/10.1016/j.jcf.2019.05.016.
    10.1016/j.jcf.2019.05.016
  32. Loureiro, Cláudia Almeida; Santos, João D.; Matos, Ana Margarida; Jordan, Peter; Matos, Paulo; Farinha, Carlos M.; Pinto, Francisco R.. "Network Biology Identifies Novel Regulators of CFTR Trafficking and Membrane Stability". Frontiers in Pharmacology 10 (2019): http://dx.doi.org/10.3389/fphar.2019.00619.
    10.3389/fphar.2019.00619
  33. Santos, João D.; Canato, Sara; Carvalho, Ana S.; Botelho, Hugo M.; Aloria, Kerman; Amaral, Margarida D.; Matthiesen, Rune; Falcao, Andre O.; Farinha, Carlos M.. "Folding Status Is Determinant over Traffic-Competence in Defining CFTR Interactors in the Endoplasmic Reticulum". Cells 8 4 (2019): 353. http://dx.doi.org/10.3390/cells8040353.
    10.3390/cells8040353
  34. Awatade, Nikhil T.; Ramalho, Sofia; Silva, Iris A.L.; Felício, Verónica; Botelho, Hugo M.; de Poel, Eyleen; Vonk, Annelotte; et al. "R560S: A class II CFTR mutation that is not rescued by current modulators". Journal of Cystic Fibrosis 18 2 (2019): 182-189. https://doi.org/10.1016/j.jcf.2018.07.001.
    Publicado • 10.1016/j.jcf.2018.07.001
  35. Cruz, Daniel F.; Farinha, Carlos M.; Swiatecka-Urban, Agnieszka. "Unraveling the Function of Lemur Tyrosine Kinase 2 Network". Frontiers in Pharmacology 10 (2019): http://dx.doi.org/10.3389/fphar.2019.00024.
    10.3389/fphar.2019.00024
  36. Vera F. C. Ferreira; Bruno L. Oliveira; João D. Santos; João D. G. Correia; Carlos M. Farinha; Filipa Mendes. "Targeting of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Protein with a Technetium-99m Imaging Probe". ChemMedChem 13 14 (2018): 1469-1478. https://doi.org/10.1002/cmdc.201800187.
    10.1002/cmdc.201800187
  37. Canato, Sara; Santos, João D.; Carvalho, Ana S.; Aloria, Kerman; Amaral, Margarida D.; Matthiesen, Rune; Falcao, André O.; Farinha, Carlos M.. "Proteomic interaction profiling reveals KIFC1 as a factor involved in early targeting of F508del-CFTR to degradation". Cellular and Molecular Life Sciences 75 24 (2018): 4495-4509. https://doi.org/10.1007/s00018-018-2896-7.
    Publicado • 10.1007/s00018-018-2896-7
  38. Jia Liu; Hermann Bihler; Carlos M Farinha; Nikhil T Awatade; Ana M Romão; Dayna Mercadante; Yi Cheng; et al. "Partial rescue of F508del-cystic fibrosis transmembrane conductance regulator channel gating with modest improvement of protein processing, but not stability, by a dual-acting small molecule". British Journal of Pharmacology (2018): https://doi.org/10.1111/bph.14141.
    10.1111/bph.14141
  39. Carlos M. Farinha; Paulo Matos; Farinha, Carlos; Matos, Paulo. "Rab GTPases regulate the trafficking of channels and transporters – a focus on cystic fibrosis". Small GTPases (2018): 1-9. https://doi.org/10.1080/21541248.2017.1317700.
    10.1080/21541248.2017.1317700
  40. Carlos M. Farinha; Elizabeth Miller; Nael McCarty. "Protein and lipid interactions – Modulating CFTR trafficking and rescue". Journal of Cystic Fibrosis 17 2 (2018): S9-S13. https://doi.org/10.1016/j.jcf.2017.08.014.
    10.1016/j.jcf.2017.08.014
  41. Farinha, Carlos M.; Canato, Sara. "From the endoplasmic reticulum to the plasma membrane: mechanisms of CFTR folding and trafficking". Cellular and Molecular Life Sciences 74 1 (2017): 39-55. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000392055900004&KeyUID=WOS:000392055900004.
    10.1007/s00018-016-2387-7
  42. Miguel J. Lobo; Margarida D. Amaral; Manuela Zaccolo; Carlos M. Farinha. "EPAC1 activation by cAMP stabilizes CFTR at the membrane by promoting its interaction with NHERF1". Journal of Cell Science 129 13 (2016): 2599-2612. https://doi.org/10.1242/jcs.185629.
    10.1242/jcs.185629
  43. Farinha, Carlos M.; Swiatecka-Urban, Agnieszka; Brautigan, David L.; Jordan, Peter. "Regulatory crosstalk by protein kinases on CFTR trafficking and activity". (2016): http://hdl.handle.net/10400.18/3915.
    Acesso aberto • Front Chem. 2016 Jan 20;4:1. doi: 10.3389/fchem.2016.00001. eCollection 2016.
  44. Farinha, Carlos M.; Matos, Paulo. "Repairing the basic defect in cystic fibrosis – one approach is not enough". The FEBS Journal 283 2 (2015): 246-264. https://doi.org/10.1111/febs.13531.
    Publicado • 10.1111/febs.13531
  45. Farinha, Carlos M; Sousa, Marisa; Canato, Sara; Schmidt, Andre; Uliyakina, Inna; Amaral, Margarida D. "Increased efficacy of VX-809 in different cellular systems results from an early stabilization effect of F508del-CFTR.". Pharmacology research & perspectives 3 4 (2015): e00152-e00152. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=MEDLINE&KeyUT=MEDLINE:26171232&KeyUID=MEDLINE:26171232.
    10.1002/prp2.152
  46. Awatade, Nikhil T; Uliyakina, Inna; Farinha, Carlos M; Clarke, Luka A; Mendes, Karina; Sole, Amparo; Pastor, Juan; Ramos, Maria Margarida; Amaral, Margarida D. "Measurements of Functional Responses in Human Primary Lung Cells as a Basis for Personalized Therapy for Cystic Fibrosis.". EBioMedicine 2 2 (2015): 147-53. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=MEDLINE&KeyUT=MEDLINE:26137539&KeyUID=MEDLINE:26137539.
    10.1016/j.ebiom.2014.12.005
  47. Xu, Zhe; Pissarra, Luisa S.; Farinha, Carlos M.; Liu, Jia; Cai, Zhiwei; Thibodeau, Patrick H.; Amaral, Margarida D.; Sheppard, David N.. "Revertant mutants modify, but do not rescue, the gating defect of the cystic fibrosis mutant G551D-CFTR". Journal of Physiology-London 592 9 (2014): 1931-1947. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000335120100007&KeyUID=WOS:000335120100007.
    10.1113/jphysiol.2014.271817
  48. Luz, Simao; Cihil, Kristine M.; Brautigan, David L.; Amaral, Margarida D.; Farinha, Carlos M.; Swiatecka-Urban, Agnieszka. "LMTK2-mediated Phosphorylation Regulates CFTR Endocytosis in Human Airway Epithelial Cells". Journal of Biological Chemistry 289 21 (2014): 15080-15093. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000337248100059&KeyUID=WOS:000337248100059.
    10.1074/jbc.M114.563742
  49. Amaral, M.D.; Farinha, C.M.. "Rescuing mutant CFTR: a multi-task approach to a better outcome in treating cystic fibrosis.". Current pharmaceutical design 19 19 (2013): 3497-3508. http://www.scopus.com/inward/record.url?eid=2-s2.0-84883448606&partnerID=MN8TOARS.
  50. Amaral, M.D.; Farinha, C.M.. "Post-translational modifications of CFTR: Insight into protein trafficking and cystic fibrosis disease". FEBS Journal 280 18 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84883457537&partnerID=MN8TOARS.
    10.1111/febs.12345
  51. Tosoni, K.; Stobbart, M.; Cassidy, D.M.; Venerando, A.; Pagano, M.A.; Luz, S.; Amaral, M.D.; et al. "CFTR mutations altering CFTR fragmentation". Biochemical Journal 449 1 (2013): 295-305. http://www.scopus.com/inward/record.url?eid=2-s2.0-84870934566&partnerID=MN8TOARS.
    10.1042/BJ20121240
  52. Farinha, C.M.; Matos, P.; Amaral, M.D.. "Control of cystic fibrosis transmembrane conductance regulator membrane trafficking: Not just from the endoplasmic reticulum to the Golgi". FEBS Journal 280 18 (2013): 4396-4406. http://www.scopus.com/inward/record.url?eid=2-s2.0-84883465161&partnerID=MN8TOARS.
    10.1111/febs.12392
  53. Farinha, C.M.; King-Underwood, J.; Sousa, M.; Correia, A.R.; Henriques, B.J.; Roxo-Rosa, M.; Da Paula, A.C.; et al. "Revertants, low temperature, and correctors reveal the mechanism of F508del-CFTR rescue by VX-809 and suggest multiple agents for full correction". Chemistry and Biology 20 7 (2013): 943-955. http://www.scopus.com/inward/record.url?eid=2-s2.0-84880894290&partnerID=MN8TOARS.
    10.1016/j.chembiol.2013.06.004
  54. Faria, D.; Lentze, N.; Almaça, J.; Luz, S.; Alessio, L.; Tian, Y.; Martins, J.P.; et al. "Regulation of ENaC biogenesis by the stress response protein SERP1". Pflugers Archiv European Journal of Physiology 463 6 (2012): 819-827. http://www.scopus.com/inward/record.url?eid=2-s2.0-84862615477&partnerID=MN8TOARS.
    10.1007/s00424-012-1091-1
  55. Mendes, F.; Farinha, C.M.; Felício, V.; Alves, P.C.; Vieira, I.; Amaral, M.D.. "BAG-1 stabilizes mutant F508del-CFTR in a ubiquitin-like-domain-dependent manner". Cellular Physiology and Biochemistry 30 5 (2012): 1120-1133. http://www.scopus.com/inward/record.url?eid=2-s2.0-84869203984&partnerID=MN8TOARS.
    10.1159/000343303
  56. Luz, S.; Kongsuphol, P.; Mendes, A. I.; Romeiras, F.; Sousa, M.; Schreiber, R.; Matos, P.; et al. "Contribution of Casein Kinase 2 and Spleen Tyrosine Kinase to CFTR Trafficking and Protein Kinase A-Induced Activity". Molecular and Cellular Biology 31 22 (2011): 4392-4404.
    Publicado • 10.1128/MCB.05517-11
  57. Mendes, A. I.; Matos, P.; Moniz, S.; Luz, S.; Amaral, M. D.; Farinha, C. M.; Jordan, P.. "Antagonistic Regulation of Cystic Fibrosis Transmembrane Conductance Regulator Cell Surface Expression by Protein Kinases WNK4 and Spleen Tyrosine Kinase". Molecular and Cellular Biology 31 19 (2011): 4076-4086.
    Publicado • 10.1128/MCB.05152-11
  58. Ramalho, Anabela S.; Lewandowska, Marzena A.; Farinha, Carlos M.; Mendes, Filipa; Gonçalves, Juan; Barreto, Celeste; Harris, Ann; Amaral, Margarida D.. "Deletion of CFTR Translation Start Site Reveals Functional Isoforms of the Protein in CF Patients". Cellular Physiology and Biochemistry 24 5-6 (2009): 335-346.
    Publicado • 10.1159/000257426
  59. Pissarra, Luísa S.; Farinha, Carlos M.; Xu, Zhe; Schmidt, André; Thibodeau, Patrick H.; Cai, Zhiwei; Thomas, Philip J.; Sheppard, David N.; Amaral, Margarida D.. "Solubilizing Mutations Used to Crystallize One CFTR Domain Attenuate the Trafficking and Channel Defects Caused by the Major Cystic Fibrosis Mutation". Chemistry & Biology 15 1 (2008): 62-69.
    Publicado • 10.1016/j.chembiol.2007.11.012
  60. Farinha, Carlos M.; Freire, Ana Ponces. "Teaching biochemistry at Lisbon University—Facing the challenge of the Bologna Declaration in the 25th anniversary of the biochemistry course". Biochemistry and Molecular Biology Education 35 6 (2007): 422-424.
    Publicado • 10.1002/bmb.114
  61. da Paula, Ana; Ramalho, Anabela; Farinha, Carlos; Cheung, Judy; Maurisse, Rosalie; Gruenert, Dieter; Ousingsawat, Jiraporn; Kunzelmann, Karl; Amaral, Margarida. "Characterization of Novel Airway Submucosal Gland Cell Models for Cystic Fibrosis". Cellular Physiology and Biochemistry 15 6 (2005): 251-262.
    Publicado • 10.1159/000087235
  62. Farinha, C. M.; Amaral, M. D.. "Most F508del-CFTR Is Targeted to Degradation at an Early Folding Checkpoint and Independently of Calnexin". Molecular and Cellular Biology 25 12 (2005): 5242-5252.
    Publicado • 10.1128/MCB.25.12.5242-5252.2005
  63. FARINHA, C. "Biochemical methods to assess CFTR expression and membrane localization". Journal of Cystic Fibrosis 3 Suppl 2 (2004): 73-77.
    Publicado • 10.1016/j.jcf.2004.05.017
  64. MENDES, F; Amaral, Margarida D.. "Antibodies for CFTR studies". Journal of Cystic Fibrosis 3 Suppl 2 (2004): 69-72.
    Publicado • 10.1016/j.jcf.2004.05.016
  65. RAMALHO, A; Amaral, Margarida D.. "Methods for RNA extraction, cDNA preparation and analysis of CFTR transcripts". Journal of Cystic Fibrosis 3 Suppl 2 (2004): 11-15.
    Publicado • 10.1016/j.jcf.2004.05.004
  66. TREZISE, A; Farinha, Carlos M.; Amaral, Margarida. "Non-PCR methods for the analysis of CFTR transcripts". Journal of Cystic Fibrosis 3 Suppl 2 (2004): 25-28.
    Publicado • 10.1016/j.jcf.2004.05.005
  67. FEREC, C; Amaral, Margarida. "Analysis of genomic CFTR DNA". Journal of Cystic Fibrosis 3 Suppl 2 (2004): 7-10.
    Publicado • 10.1016/j.jcf.2004.05.003
  68. FARINHA, C. "A comparison of 14 antibodies for the biochemical detection of the cystic fibrosis transmembrane conductance regulator protein". Molecular and Cellular Probes 18 4 (2004): 235-242.
    Publicado • 10.1016/j.mcp.2004.03.005
  69. Mendes, Filipa; Roxo Rosa, Mónica; Dragomir, Anca; Farinha, Carlos M; Roomans, Godfried M; Amaral, Margarida D; Penque, Deborah. "Unusually common cystic fibrosis mutation in Portugal encodes a misprocessed protein". Biochemical and Biophysical Research Communications 311 3 (2003): 665-671.
    Publicado • 10.1016/j.bbrc.2003.10.048
  70. Farinha, Carlos; Nogueira, Paulo; Mendes, Filipa; Penque, Deborah; Amaral, Margarida. "The Hdj-1/Hsp40 co-chaperone is required for the in vivo stabilization of the Cystic Fibrosis Transmembrane Conductance Regulator by Hsp70". Biochemical Journal 366 3 (2002): 797-806.
    Publicado • 10.1042/BJ20011717
  71. Amaral, M.D.; Pacheco, P.; Beck, S.; Farinha, C.M.; Penque, D.; Nogueira, P.; Barreto, C.; et al. "Cystic fibrosis patients with the 3272-26A>G splicing mutation have milder disease than F508del homozygotes: A large European study [3]". Journal of Medical Genetics 38 11 (2001): 777-782. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034760913&partnerID=MN8TOARS.
    Publicado • 10.1136/jmg.38.11.777
  72. Penque, Deborah; Mendes, Filipa; Beck, Sebastian; Farinha, Carlos Miguel Ribeiro da Silva; Pacheco, Paula; Nogueira, Paulo; Lavinha, Jo¿o; et al. "Cystic Fibrosis F508del Patients Have Apically Localized CFTR in a Reduced Number of Airway Cells". Laboratory Investigation 80 80 (2000): 857-868. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033918281&partnerID=MN8TOARS.
    Publicado
  73. Beck, Sebastian; Penque, Deborah; Garcia, Susana; Gomes, Anita; Farinha, Carlos; Mata, Lucinda; Gulbenkian, S¿rgio; et al. "Cystic fibrosis patients with the 3272-26A?G mutation have mild disease, leaky alternative mRNA splicing, and CFTR protein at the cell membrane". Human Mutation 14 2 (1999): 133-144.
    Publicado • 10.1002/(SICI)1098-1004(1999)14:2<133::AID-HUMU5>3.0.CO;2-T
Artigo em revista (magazine)
  1. Carlos Miguel Farinha. "Eletroforese (Química Biológica)", Revista de Ciência Elementar, 2015, https://doi.org/10.24927/rce2015.238.
    10.24927/rce2015.238
Capítulo de livro
  1. Amaral, Margarida; Clarke, Luka A; Carlos M. Farinha; Botelho, Hugo. "Systems Biology and the New Omics". In Hodson and Geddes' Cystic Fibrosis, editado por Andrew Bush; Margarida D. Amaral; Jane C. Davies; Nicholas J. Simmonds; Jennifer L. Taylor-Cousar; Sarath C. Ranganathan, 96-110. Boca Raton, FL, Estados Unidos: Taylor & Francis. CRC Press, 2023.
    Publicado • 10.1201/9781003262763
  2. Amaral, Margarida D.; Farinha, Carlos M.; Matos, Paulo; Botelho, Hugo M.. "Investigating Alternative Transport of Integral Plasma Membrane Proteins from the ER to the Golgi: Lessons from the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)". In Unconventional Protein Secretion, 105-126. Springer New York, 2016.
    Publicado • 10.1007/978-1-4939-3804-9_7
  3. Farinha, Carlos Miguel Ribeiro da Silva. "Processing and intracellular trafficking of wild-type and mutant CFTR". In Proc 25th European Cystic Fibrosis Conference. Itália: Monduzzi, 2002.
    Publicado
Livro
  1. Farinha, Carlos M.. CFTR and Cystic Fibrosis. Springer International Publishing. 2017.
    Publicado • 10.1007/978-3-319-65494-2
Poster em conferência
  1. Ferreira, João; Carlos M. Farinha. "INF2: A novel dual role regulator of CFTR". Trabalho apresentado em North American Cystic Fibrosis Conference, 2023.
  2. Santos, Lúcia; Joana Alves; Carlos M. Farinha; Harrison, Patrick T.. "A precise adenine base editor corrects W1282X-CFTR without bystander effects.". Trabalho apresentado em 18th ECFS Basic Science Conference, 2023.
  3. Pankonien, Ines; Cláudia Rodrigues; Filipa B. Simões; Santos, Lúcia; Carlos M. Farinha; Margarida D. Amaral. "Role of CFTR in airway epithelial regeneration and repair: studies from novel human basal cell lines". Trabalho apresentado em 18th ECFS Basic Science Conference, 2023.
  4. Andreia Henriques; Santos, Lúcia; Carlos M. Farinha. "Signatures associated with differentially expressed genes and proteins in G542X-CFTR: clues to novel therapeutic targets?". Trabalho apresentado em North American Cystic Fibrosis Conference, 2023.
  5. Santos, Lúcia; Joana Alves; Carlos M. Farinha; Patrick T. Harrison. "Development of an improved adenine base editor to correct W1292X-CFTR with reduced bystander effects". Trabalho apresentado em North American Cystic Fibrosis Conference, 2023.
  6. Ferreira, João F.; Silva, Iris AL; Botelho, Hugo M; Amaral, Margarida; Carlos M. Farinha. "Exploring the role of EPAC1 to stabilize CFTR in intestinal cells". Trabalho apresentado em 17th ECFS Basic Science Conference, 2022.
  7. S. Ramalho, Sofia; Santos, Lúcia; Margarida D. Amaral; André O. Falcão; Carlos M. Farinha. "Exploring the endoplasmic reticulum retention mechanisms to rescue the rare CFTR mutation N1303K". Trabalho apresentado em 17th ECFS Basic Science Conference, 2022.
  8. Karen Mention; Kader Cavusoglu-Doran; Santos, Lúcia; David J. Sanz; Anya T. Joynt; Carlos M. Farinha; Neeraj Sharma; Patrick T. Harrison. "Correction of the W1282X CFTR variant by gene editing with two techniques alternative to homology-directed repair". Trabalho apresentado em 17th ECFS Basic Science Conference, 2022.
  9. Santos, Lúcia; Nascimento, Rui; Duarte, Aires; Patrick T. Harrison; Gama-Carvalho, Margarida; Carlos M. Farinha. "Transcriptomic and proteomic analysis identify changes associated with several prototypical cystic fibrosis-causing mutations". Trabalho apresentado em 17th ECFS Basic Science Conference, 2022.
  10. Santos, Lúcia; Carlos M. Farinha; Patrick T. Harrison. "Temporal-spatial CRISPR base editing to identify target cells for genetic-based therapies". Trabalho apresentado em North American Cystic Fibrosis Conference, 2022.
  11. Ferreira, V.F.C; Correia, J.D.G; Gonçalves, J.; Farinha, Carlos Miguel Ribeiro da Silva; Mendes, Filipa. "Novel Molecular Imaging Tools for Cystic Fibrosis". Trabalho apresentado em C2TN Annual Workshop, 2018.
  12. Ferreira, V.F.C; Farinha, Carlos Miguel Ribeiro da Silva; Mendes, Filipa; Correia, J.D.G.; Gonçalves, J.. "New Molecular Imaging Tools for Cystic Fibrosis". Trabalho apresentado em PhD Open Days, 2017.
  13. Ferreira, V.F.C; Oliveira, B.L.; Correia, J.D.G.; Farinha, Carlos Miguel Ribeiro da Silva; Mendes, Filipa. "Molecular Imaging probes for in vivo detection of CFTR". Trabalho apresentado em 12th ECFS Basic Science Conference, 2015.
  14. Ferreira, V.F.C; Oliveira, B.L.; Correia, J.D.G.; Santos, I.; Farinha, Carlos Miguel Ribeiro da Silva; Mendes, Filipa. "Molecular Imaging probes for in vivo detection of the Cystic Fibrosis protein". Trabalho apresentado em 2nd International Symposium on Functional Metal Complexes that Bind to Biomolecules, 2014.
  15. Ferreira, V.F.C; Oliveira, B.L.; Santos, I.; Peters, K.W.; Farinha, Carlos Miguel Ribeiro da Silva; Mendes, Filipa. "Radiolabelling of anti-CFTR antibodies for the detection of CFTR". Trabalho apresentado em 11th ECFS Basic Science Conference, 2014.
  16. Ferreira, V.F.C; Oliveira, B.L.; Correia, J.D.G.; Santos, I.; Farinha, Carlos Miguel Ribeiro da Silva; Mendes, Filipa. "Novel radiolabelled probes for in vivo detection of CFTR". Trabalho apresentado em 11th ECFS Basic Science Conference, 2014.
Resumo em conferência
  1. Ferreira, João F.; Carlos M. Farinha. "Role of cytoskeleton modulators in regulating CFTR membrane stability and rescue". Trabalho apresentado em North American Cystic Fibrosis Conference, San Antonio, Texas, 2021.
    Publicado
  2. Farinha, Carlos Miguel Ribeiro da Silva. "Cytoskeleton Regulators Associate with CFTR to Control Its Membrane Levels Under EPAC1 Activation". Trabalho apresentado em North American Cystic Fibrosis Conference, 2019.
    Publicado
  3. Farinha, Carlos Miguel Ribeiro da Silva. "Gene and Base Edited Cell Models of Cystic-Fibrosis Causing Mutations". Trabalho apresentado em 22nd Meeting ASCGT, 2019.
    Publicado
  4. Farinha, Carlos Miguel Ribeiro da Silva. "Understanding the regulation of TGF-ß1 signaling pathway in cystic fibrosis: the role of PP1 and LMTK2". Trabalho apresentado em North American Cystic Fibrosis Conference, 2018.
    Publicado
  5. Farinha, Carlos Miguel Ribeiro da Silva; Sara Canato; João D. Santos; Ana S. Carvalho; Kerman Aloria; Margarida D. Amaral; Rune Matthiesen; André O. Falcao; Carlos M. Farinha. "Proteomic Interaction Profiling Reveals KIFC1 as a Factor involved in Early Targeting of F508del-CFTR to Degradation". Trabalho apresentado em North American Cystic Fibrosis Conference, 2018.
    Publicado • 10.1007/s00018-018-2896-7
  6. Farinha, Carlos Miguel Ribeiro da Silva. "From the bench to bedside: expanding CFTR modulators to rare mutations by response assessment in patients-derived materials and cellular models". Trabalho apresentado em European Cystic Fibrosis Conference, 2018.
  7. Farinha, Carlos Miguel Ribeiro da Silva. "Functional and Biochemical Assessment of Correctors and Potentiators on the Rare Cystic Fibrosis-Causing R560S mutation". Trabalho apresentado em North American Cystic Fibrosis Conference, 2017.
    Publicado
  8. Farinha, Carlos Miguel Ribeiro da Silva. "Modulation of protein traffic networks to rescue F508del-CFTR from the endoplasmic reticulum". Trabalho apresentado em European Cystic Fibrosis Conference, 2017.
    Publicado
  9. Farinha, Carlos Miguel Ribeiro da Silva. "TGF-ß signaling in cystic fibrosis – a role for LMTK2 and PP1C". Trabalho apresentado em North American Cystic Fibrosis Conference, 2015.
    Publicado
  10. Farinha, Carlos Miguel Ribeiro da Silva. "Stabilization of CFTR at the membrane by EPAC1 activation occurs through interaction with NHERF-1". Trabalho apresentado em European Cystic Fibrosis Conference, 2015.
    Publicado
  11. Farinha, Carlos Miguel Ribeiro da Silva. "EPAC1 (Exchange Protein Activated by cAMP) is a Novel Player in CFTR Regulation by cAMP at the Cell Surface". Trabalho apresentado em North American Cystic Fibrosis Conference, 2014.
    Publicado
  12. Farinha, Carlos Miguel Ribeiro da Silva. "EXCHANGE PROTEIN DIRECTLY ACTIVATED BY cAMP (EPAC) – A NOVEL CFTR INTERACTOR". Trabalho apresentado em North American Cystic Fibrosis Conference, 2013.
    Publicado
  13. Farinha, Carlos Miguel Ribeiro da Silva. "Exchange proteins directly activated by cyclic AMP: Novel CFTR interactors?". Trabalho apresentado em European Cystic Fibrosis Conference, 2013.
    Publicado
  14. Farinha, Carlos Miguel Ribeiro da Silva. "Screening for novel F508del-CFTR correctors identified by pharmacophore modelling through automated microscopy and NBD1 folding assays". Trabalho apresentado em European Cystic Fibrosis Conference, 2013.
    Publicado
  15. Farinha, Carlos Miguel Ribeiro da Silva. "LMTK2 regulates CFTR endocytosis by phosphorylation at CFTR Ser-737". Trabalho apresentado em European Cystic Fibrosis Conference, 2013.
    Publicado
  16. Cunha da Luz, S.; Cihil, K.; Thibodeau, P. H.; Brautigan, D. L.; Amaral, M. D.; Farinha, C. M.; Swiatecka-Urban, A.. "LMTK2 facilitates CFTR endocytosis by phosphorylation at CFTR Ser-737 residue". 2012.
  17. Farinha, Carlos Miguel Ribeiro da Silva. "Folding, traffic and kinetic defects account for F508del-CFTR retention in the endoplasmic reticulum". Trabalho apresentado em North American Cystic Fibrosis Conference, 2012.
    Publicado
  18. Farinha, Carlos Miguel Ribeiro da Silva. "Phosphorylation of CFTR Ser-737 Residue by LMTK2 Regulates CFTR Endocytosis". Trabalho apresentado em North American Cystic Fibrosis Conference, 2012.
    Publicado
  19. Farinha, Carlos Miguel Ribeiro da Silva. "LMTK2 facilitates CFTR endocytosis by phosphorylation at CFTR Ser-737 residue". Trabalho apresentado em FEBS Annual Meeting, 2012.
    Publicado
  20. Farinha, Carlos Miguel Ribeiro da Silva. "The contribution of CK2 and SYK to CFTR trafficking and PKA-induced activity". Trabalho apresentado em North American Cystic Fibrosis Conference, 2011.
    Publicado
  21. Farinha, Carlos Miguel Ribeiro da Silva. "Spleen Tyrosine Kinase (SYK) – a novel target involved in CFTR biogenesis and trafficking". Trabalho apresentado em North American Cystic Fibrosis Conference, 2011.
    Publicado
  22. Farinha, Carlos Miguel Ribeiro da Silva. "Rescuing F508del-CFTR by genetic revertants, low temperature and small molecules". Trabalho apresentado em North American Cystic Fibrosis Conference, 2010.
    Publicado
  23. Farinha, Carlos Miguel Ribeiro da Silva. "Restoration of ATP-Dependence to the CF Mutant G551D by the Revertant Mutation 4RK". Trabalho apresentado em North American Cystic Fibrosis Conference, 2010.
    Publicado
  24. Farinha, Carlos Miguel Ribeiro da Silva. "TMEM45A: a novel centrosome/basal body protein implicated in CF Pathophysiology". Trabalho apresentado em North American Cystic Fibrosis Conference, 2010.
    Publicado
  25. Farinha, Carlos Miguel Ribeiro da Silva. "Biochemical Analyses of Potential CK2-sites in CFTR". Trabalho apresentado em North American Cystic Fibrosis Conference, 2009.
    Publicado
  26. Farinha, Carlos Miguel Ribeiro da Silva. "A Role for Spleen Tyrosine Kinase (SYK) in CFTR Processing and Trafficking". Trabalho apresentado em North American Cystic Fibrosis Conference, 2009.
    Publicado
  27. Farinha, Carlos Miguel Ribeiro da Silva. "A role for CK2 and SYK in CFTR maturation and trafficking?". Trabalho apresentado em North American Cystic Fibrosis Conference, 2008.
    Publicado
  28. Farinha, Carlos Miguel Ribeiro da Silva. "A role for casein kinase 2 in the early steps of CFTR biogenesis?". Trabalho apresentado em North American Cystic Fibrosis Conference, 2007.
    Publicado
  29. Farinha, Carlos Miguel Ribeiro da Silva. "Analysis of the effects of the revertant mutations G550E and 4RK on the expression and function of G551D-CFTR". Trabalho apresentado em North American Cystic Fibrosis Conference, 2007.
    Publicado
  30. Farinha, Carlos Miguel Ribeiro da Silva. "The Effect of F508del-NBD1 Solubilizing Mutations in Full Length CFTR". Trabalho apresentado em North American Cystic Fibrosis Conference, 2006.
    Publicado
  31. Farinha, Carlos Miguel Ribeiro da Silva. "Role of Bag-1 on Turnover and Processing of Wild-Type and F508del-CFTR". Trabalho apresentado em North American Cystic Fibrosis Conference, 2006.
    Publicado
  32. Farinha, Carlos Miguel Ribeiro da Silva. "Low Temperature Studies Suggest Conformational Differences Between Wild-Type and F508del-CFTR". Trabalho apresentado em North American Cystic Fibrosis Conference, 2006.
    Publicado
  33. Farinha, Carlos Miguel Ribeiro da Silva. "Biochemical and Functional Characterization of CFTR Glycosylation-Null Mutants". Trabalho apresentado em European Cystic Fibrosis Conference, 2005.
    Publicado
  34. Farinha, Carlos Miguel Ribeiro da Silva. "Glycosylation and Calnexin in the ER Quality Control of CFTR". Trabalho apresentado em European Cystic Fibrosis Conference, 2004.
    Publicado
  35. Farinha, Carlos Miguel Ribeiro da Silva. "Effect of Glycosidases Inhibitors on the ER-associated Degradation of the wt- and F508del-CFTR". Trabalho apresentado em North American Cystic Fibrosis Conference, 2003.
    Publicado
  36. Farinha, Carlos Miguel Ribeiro da Silva; Sommerburg, O; Yang, Y; Rizio, AA; Loop, B; You, X; Kosinski, M; et al. "Turnover and Processing of wt- and F508del-CFTR at Low Temperature". Trabalho apresentado em North American Cystic Fibrosis Conference, 2002.
    Publicado • 10.1055/s-0039-1678165
  37. Farinha, Carlos Miguel Ribeiro da Silva. "Processing and Intracellular Trafficking of normal and mutant CFTR". Trabalho apresentado em European Cystic Fibrosis Conference, 2002.
    Publicado
  38. Farinha, Carlos Miguel Ribeiro da Silva. "Low Temperature Effect upon CFTR Turnover and Processing". Trabalho apresentado em European Cystic Fibrosis Conference, 2002.
    Publicado
  39. Farinha, Carlos Miguel Ribeiro da Silva. "The Effect of R555K or G550E traffic restoring substitutions upon A561E-CFTR processing". Trabalho apresentado em European Cystic Fibrosis Conference, 2002.
    Publicado
  40. Farinha, Carlos Miguel Ribeiro da Silva. "Stabilization of the Immature Form of wild-type CFTR by the Hsp70/Hdj-1 Chaperone Pair". Trabalho apresentado em North American Cystic Fibrosis Conference, 2001.
    Publicado
  41. Farinha, Carlos Miguel Ribeiro da Silva. "The Misprocessing of A561E-CFTR is partially corrected by R555K or G550E traffic restoring substitutions". Trabalho apresentado em North American Cystic Fibrosis Conference, 2001.
    Publicado
  42. Farinha, Carlos Miguel Ribeiro da Silva. "Potential role of calnexin in the endoplasmic reticulum retention of F508del-CFTR". Trabalho apresentado em North American Cystic Fibrosis Conference, 2000.
    Publicado
  43. Farinha, Carlos Miguel Ribeiro da Silva. "Biosynthesis of wild-type and F508del CFTR in cells expressing high levels of Hsp70 chaperone". Trabalho apresentado em North American Cystic Fibrosis Conference, 1999.
    Publicado
  44. Farinha, Carlos Miguel Ribeiro da Silva. "In vivo effect of BAG-1, a modulator of Hsc70/Hsp70 activity, on the turnover and processing of wild-type and F508del-CFTR". Trabalho apresentado em North American Cystic Fibrosis Conference, 1999.
    Publicado
  45. Farinha, Carlos Miguel Ribeiro da Silva. "Mild splicing mutation 3272-26A-G: effects on respiratory epithelium". Trabalho apresentado em North American Cystic Fibrosis Conference, 1998.
    Publicado
  46. Farinha, Carlos Miguel Ribeiro da Silva. "The Natural Stress Protectant Trehalose Alters Intracellular Localization of Mutant CFTR Protein". Trabalho apresentado em North American Cystic Fibrosis Conference, 1997.
    Publicado
  47. Farinha, Carlos Miguel Ribeiro da Silva. "Novel A561E CFTR Mutation Found in Portuguese Patients Associated with Mislocalization Distinct from DF508". Trabalho apresentado em North American Cystic Fibrosis Conference, 1997.
    Publicado
  48. Farinha, Carlos Miguel Ribeiro da Silva. "Expression of HSP70 and Calnexin in Cells Transfected with Wild Type and DF508 CFTR cDNA". Trabalho apresentado em North American Cystic Fibrosis Conference, 1996.
    Publicado
Tese / Dissertação
  1. Farinha, Carlos Miguel Ribeiro da Silva. "Processing and Intracellular Trafficking of wild-type and mutant CFTR". Doutoramento, Universidade de Lisboa Faculdade de Ciências, 2003.
  2. Farinha, Carlos Miguel Ribeiro da Silva. "Estudos de Expressão do Gene CFTR associado à Fibrose Quística". Licenciatura, Universidade de Lisboa Faculdade de Ciências, 1995.

Outros

Outra produção
  1. Full Rescue of F508del-CFTR Processing and Function by CFTR Modulators can be Achieved by Removal of Two Unique Regulatory Regions. 2018. Inna Uliyakina; Ana C Da Paula; Sara C Afonso; Miguel J Lobo; Veronica Felicio; Hugo M Botelho; Carlos M Farinha; Margarida D Amaral. https://doi.org/10.1101/320630.
    10.1101/320630
Distinções

Prémio

2012 Romain Pauwels Research Award
European Respiratory Society, Suiça