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Identificação

Identificação pessoal

Nome completo
Leping Yan
Género
Masculino

Identificadores de autor

Ciência ID
D117-EFAE-39F8
ORCID iD
0000-0002-4806-5052
Formação
Grau Classificação
2010/01/01 - 2014/06/16
Concluído
 Engenharia de Tecidos, Medicina Regenerativa e Células Estaminais (Doutoramento)
Especialização em Sem especialidade
Universidade do Minho, Portugal
"Silk fibroin-based scaffolds, hydrogels and calcium-phosphate filled materials aimed for regenerative medicine applications" (TESE/DISSERTAÇÃO)
2004/09/01 - 2008/05/28
Concluído
 Biomedical Engineering (Postgraduate Certificate)
South China University of Technology, China
"Genipin crosslinked bilayered collagen/chitosan/beta-calcium phosphate scaffold for osteochondral regeneration " (TESE/DISSERTAÇÃO)
2000/09/01 - 2004/07/01
Concluído
 Polymer Engineering and Science (Bachelor)
South China University of Technology, China
" Development and characterization of glass fibre reinforced flame-retardant PET engineering plastic " (TESE/DISSERTAÇÃO)
 First Class
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2019/06/17 - Atual Investigador principal (carreira) (Investigação) The Seventh Affiliated Hospital Sun Yat-sen University, China
Guangdong Provincial Key Laboratory of Digestive Cancer Research, The Seventh Affiliated Hospital, Sun Yat-sen University, China
2018/09/17 - 2019/06/14 Investigador (Investigação) South China University of Technology, China
School of Biomedical Science and Engineering, China
2016/06 - 2018/07/31 Pós-doutorado (Investigação) Royal College of Surgeons in Ireland, Irlanda
Department of Anatomy & Regenerative Medicine, Irlanda
2015/03/04 - 2016/03/03 Pós-doutorado (Investigação) The University of Sydney, Austrália
The University of Sydney Charles Perkins Centre, Austrália
2008/06/02 - 2009/12/31 Investigador (Investigação) Universidade do Minho, Portugal
Universidade do Minho Biomaterials Biodegradables and Biomimetics Research Group, Portugal
Projetos

Bolsa

Designação Financiadores
2021/01/01 - 2022/12/31 Digestive system tumor-on-chip model and precision medicine
G2021XXX001X
Investigador
Guangdong Provincial Key Laboratory of Digestive Cancer Research, The Seventh Affiliated Hospital, Sun Yat-sen University, China
Ministry of Science and Technology of the People's Republic of China
Em curso
2020/01/01 - 2022/12/31 Immunomodulatory hydrogels for improved wound healing
ZSQYRSF0008
Investigador responsável
The Seventh Affiliated Hospital Sun Yat-sen University, China
 The Seventh Affiliated Hospital Sun Yat-sen University
Em curso
2020/01/01 - 2022/12 Gene-activated bioactive system for improved healing of diabetic foot ulcer
20ykpy18
Investigador responsável
The Seventh Affiliated Hospital Sun Yat-sen University, China
 Sun Yat-Sen University
Em curso
Produções

Publicações

Artigo em conferência
  1. Ribeiro, Viviana Pinto; Leping, Yan; Oliveira, Ana Leite Almeida Monteiro; Oliveira, J. M.; Reis, R. L.. "Combinatory approach for developing silk fibroin-based scaffolds with hierarchical porosity and enhanced performance for cartilage tissue engineering applications". 2016.
    10.3389/conf.FBIOE.2016.01.01708
  2. "Silk fibroin/nano-CaP bilayered scaffolds for osteochondral tissue engineering". 2014.
    10.4028/www.scientific.net/KEM.587.245
  3. Yan, Leping; Oliveira, Joaquim M.; Oliveira, A. L.; Reis, R. L.. "Silk Fibroin/Nano-CaP Bilayered scaffolds for osteochondral tissue engineering". 2014.
    10.4028/www.scientific.net/KEM.587.245
  4. Yan, Leping; Vilela, Carlos; Pereira, H.; Sousa, R. A.; Oliveira, A. L.; Oliveira, Joaquim M.; Reis, R. L.. "Silk bilayer scaffolds can induce fast integration with subchondral bone and support cartilage repair". 2014.
  5. "Silk-Fibroin/Methacrylated Gellan Gum Hydrogel as an novel scaffold for application in meniscus cell-based tissue engineering". 2013.
    http://dx.doi.org/10.1016/j.arthro.2013.07.038
  6. Yan, Leping; Correia, C.; Pereira, D. R.; Sousa, R. A.; Oliveira, Joaquim M.; Oliveira, A. L.; Reis, R. L.. "Injectable silk fibroin hydrogels with ionic strength and pH response for tissue engineering and regenerative medicine applications". 2013.
    10.1002/term.1822
  7. Pereira, H.; Silva-Correia, Joana; Yan, Leping; Caridade, S. G.; Frias, A. M.; Oliveira, A. L.; Mano, J. F.; et al. "Silk-Fibroin/Methacrylated Gellan Gum Hydrogel as an novel scaffold for application in meniscus cell-based tissue engineering". 2013.
  8. Yan, Leping; Oliveira, Joaquim M.; Oliveira, A. L.; Reis, R. L.. "Development of a bilayered scaffold based on silk fibroin and silk fibroin/nano-calcium phosphate for osteochondral regeneration". 2012.
  9. Yan, Leping; Correia, Cristina; Silva-Correia, Joana; Caridade, S. G.; Fernandes, E. M.; Mano, J. F.; Sousa, R. A.; et al. "Development of macro/micro porous silk fibroin scaffolds with nano-sized calcium phosphate particles for bone tissue engineering". 2012.
    10.1002/term.1586
  10. Silva-Correia, Joana; Pereira, H.; Yan, Leping; Gonçalves, Vera M.; Oliveira, A. L.; Oliveira, Joaquim M.; Reis, R. M.; Mendes, João Espregueira; Reis, R. L.. "Advanced mimetic materials for meniscus tissue engineering : targeting segmental vascularization". 2012.
  11. Yan, Leping; Oliveira, Joaquim M.; Oliveira, Ana Leite; Caridade, S. G.; Mano, J. F.; Reis, R. L.. "Macro/micro porous silk fibroin scaffolds obtained via combined methodologies for articular cartilage and meniscus tissue engineering". 2011.
  12. Yan, Leping; Oliveira, Joaquim M.; Oliveira, Ana Leite; Caridade, S. G.; Mano, J. F.; Reis, R. L.. "Preparation and characterization of water-soluble C60/Silk fibroin nanocomposite for cartilage regeneration application". 2011.
Artigo em revista
  1. "METTL3 promotes oxaliplatin resistance of gastric cancer CD133+¿stem cells by promoting PARP1 mRNA stability". Cellular and Molecular Life Sciences 79 3 (2022): http://dx.doi.org/10.1007/s00018-022-04129-0.
    10.1007/s00018-022-04129-0
  2. "An efficient and user-friendly method for cytohistological analysis of organoids". Journal of Tissue Engineering and Regenerative Medicine 15 11 (2021): 1012-1022. http://dx.doi.org/10.1002/term.3248.
    10.1002/term.3248
  3. "Development of a cellulose-based prosthetic mesh for pelvic organ prolapse treatment: In vivo long-term evaluation in an ewe vagina model". Materials Today Bio 12 (2021): 100172-100172. http://dx.doi.org/10.1016/j.mtbio.2021.100172.
    10.1016/j.mtbio.2021.100172
  4. "PARP1 Inhibitor Combined With Oxaliplatin Efficiently Suppresses Oxaliplatin Resistance in Gastric Cancer-Derived Organoids via Homologous Recombination and the Base Excision Repair Pathway". Frontiers in Cell and Developmental Biology 9 (2021): http://dx.doi.org/10.3389/fcell.2021.719192.
    10.3389/fcell.2021.719192
  5. "Development and Characterization of High Efficacy Cell-Penetrating Peptide via Modulation of the Histidine and Arginine Ratio for Gene Therapy". Materials 14 16 (2021): 4674-4674. http://dx.doi.org/10.3390/ma14164674.
    10.3390/ma14164674
  6. "High expression of vinculin predicts poor prognosis and distant metastasis and associates with influencing tumor-associated NK cell infiltration and epithelial-mesenchymal transition in gastric cancer". Aging 13 4 (2021): 5197-5225. http://dx.doi.org/10.18632/aging.202440.
    10.18632/aging.202440
  7. "Collagen/GAG scaffolds activated by RALA-siMMP-9 complexes with potential for improved diabetic foot ulcer healing". Materials Science and Engineering: C (2020): http://dx.doi.org/10.1016/j.msec.2020.111022.
    10.1016/j.msec.2020.111022
  8. "Robust and nanostructured chitosan–silica hybrids for bone repair application". Journal of Materials Chemistry B (2020): http://dx.doi.org/10.1039/d0tb00009d.
    10.1039/d0tb00009d
  9. "CIAPIN1 is a potential target for apoptosis of multiple myeloma". Materials Express (2019): http://dx.doi.org/10.1166/mex.2019.1601.
    10.1166/mex.2019.1601
  10. "Tropoelastin Implants That Accelerate Wound Repair". Advanced Healthcare Materials (2018): http://dx.doi.org/10.1002/adhm.201701206.
    10.1002/adhm.201701206
  11. Yan, Leping; Oliveira, J. M.; Oliveira, A. L.; Reis, R. L.. "Core-shell silk hydrogels with spatially tuned conformations as drug delivery system". (2017): http://hdl.handle.net/1822/44166.
    10.1002/term.2226
  12. "Tumor Growth Suppression Induced by Biomimetic Silk Fibroin Hydrogels". Scientific Reports (2016): http://www.nature.com/articles/srep31037.
    10.1038/srep31037
  13. Leping, Yan; Silva-Correia, Joana; Ribeiro, Viviana Pinto; Gonçalves, Vera Mónica Miranda; Correia, Cristina; Morais, Alain José Silva; Sousa, R. A.; et al. "Tumor growth suppression induced by biomimetic silk fibroin hydrogels". (2016): http://hdl.handle.net/1822/42482.
    10.1038/srep31037
  14. "In vitro evaluation of the biological performance of macro/micro-porous silk fibroin and silk-nano calcium phosphate scaffolds". Journal of Biomedical Materials Research Part B: Applied Biomaterials 103 4 (2015): 888-898. http://onlinelibrary.wiley.com/doi/10.1002/jbm.b.33267/full.
    10.1002/jbm.b.33267
  15. "Current concepts and challenges in osteochondral tissue engineering and regenerative medicine". ACS Biomaterials Science & Engineering 1 4 (2015): 183-200. http://pubs.acs.org/doi/abs/10.1021/ab500038y.
    10.1021/ab500038y
  16. "Bilayered silk/silk-nanoCaP scaffolds for osteochondral tissue engineering: in vitro and in vivo assessment of biological performance". Acta biomaterialia 12 (2015): 227-241. http://www.sciencedirect.com/science/article/pii/S1742706114004632.
    http://dx.doi.org/10.1016/j.actbio.2014.10.021
  17. Yan, Leping; Silva-Correia, Joana; Oliveira, Mariana B.; Vilela, Carlos; Pereira, H.; Sousa, R. A.; Mano, J. F.; et al. "Bilayered silk/silk-nanoCaP scaffolds for osteochondral tissue engineering: in vitro and In vivo assessment of biological performance". (2015): http://hdl.handle.net/1822/32932.
    10.1016/j.actbio.2014.10.021
  18. Yan, Leping; Oliveira, Joaquim M.; Oliveira, Ana Leite; Reis, R. L.. "Current concepts and challenges in osteochondral tissue engineering and regenerative medicine". (2015): http://hdl.handle.net/1822/34869.
    10.1021/ab500038y
  19. Yan, L.-P.; Salgado, A.J.; Oliveira, J.M.; Oliveira, A.L.; Reis, R.L.. "De novo bone formation on macro/microporous silk and silk/nano-sized calcium phosphate scaffolds". Journal of Bioactive and Compatible Polymers 28 5 (2013): 439-452. http://www.scopus.com/inward/record.url?eid=2-s2.0-84884180115&partnerID=MN8TOARS.
    10.1177/0883911513503538
  20. Yan, L.-P.; Silva-Correia, J.; Correia, C.; Caridade, S.G.; Fernandes, E.M.; Sousa, R.A.; Mano, J.F.; et al. "Bioactive macro/micro porous silk fibroin/nano-sized calcium phosphate scaffolds with potential for bone-tissue-engineering applications". Nanomedicine 8 3 (2013): 359-378. http://www.scopus.com/inward/record.url?eid=2-s2.0-84874889929&partnerID=MN8TOARS.
    10.2217/nnm.12.118
  21. Yan, Leping; Silva-Correia, Joana; Correia, C.; Caridade, S. G.; Fernandes, E. M.; Sousa, R. A.; Mano, J. F.; et al. "Bioactive macro/micro porous silk fibroin/Nano-sized calcium phosphate scaffolds with potential for bone tissue engineering applications". (2013): http://hdl.handle.net/1822/23649.
    10.2217/NNM.12.118
  22. Yan, Leping; Salgado, A. J.; Oliveira, Joaquim M.; Oliveira, A. L.; Reis, R. L.. "De novo bone formation on macro/microporous silk and silk/nano-sized calcium phosphate scaffolds". (2013): http://hdl.handle.net/1822/25588.
    10.1177/0883911513503538
  23. "Development of silk-based scaffolds for tissue engineering of bone from human adipose-derived stem cells". Acta Biomaterialia 8 7 (2012): 2483-2492. http://www.sciencedirect.com/science/article/pii/S1742706112001055.
    10.1016/j.actbio.2012.03.019
  24. "Macro/microporous silk fibroin scaffolds with potential for articular cartilage and meniscus tissue engineering applications". Acta Biomaterialia 8 1 (2012): 289-301. http://www.sciencedirect.com/science/article/pii/S1742706112001055.
    10.1016/j.actbio.2011.09.037
  25. Correia, Cristina; Bhumiratana, Sarindr; Yan, Leping; Oliveira, A. L.; Gimble, Jeffrey M.; Rockwood, Danielle; Kaplan, David; et al. "Development of silk-based scaffolds for tissue engineering of bone from human adipose derived stem cells". (2012): http://hdl.handle.net/1822/22755.
    10.1016/j.actbio.2012.03.019
  26. Yan, Leping; Oliveira, Joaquim M.; Oliveira, Ana Leite; Caridade, S. G.; Mano, J. F.; Reis, R. L.. "Macro/microporous silk fibroin scaffolds with potential for articular cartilage and meniscus tissue engineering applications". (2012): http://hdl.handle.net/1822/14043.
    10.1016/j.actbio.2011.09.037
  27. Yan, L.-P.; Wang, Y.-J.; Ren, L.; Wu, G.; Caridade, S.G.; Fan, J.-B.; Wang, L.-Y.; et al. "Genipin-cross-linked collagen/chitosan biomimetic scaffolds for articular cartilage tissue engineering applications". Journal of Biomedical Materials Research - Part A 95 A 2 (2010): 465-475. http://www.scopus.com/inward/record.url?eid=2-s2.0-78649270937&partnerID=MN8TOARS.
    10.1002/jbm.a.32869
  28. Yan, Leping; Wang, Yingjun; Rei, Li; Wu, Gang; Caridade, S. G.; Fan, Jiabing; Wang, Lingyun; et al. "Genipin-cross-linked collagen/chitosan biomimetic scaffolds for articular cartilage tissue engineering applications". (2010): http://hdl.handle.net/1822/13864.
    10.1002/jbm.a.32869
  29. Zhu, S.-T.; Zhu, L.-X.; Yu, L.; Yan, L.-P.; Yu, Q.-L.; Huang, R.; Zhang, S.-H.; Wang, J.-X.. "In vitro culture of bone mesenchymal stem cells on the layered collagen-chitosan-beta-tricalcium phosphate composite scaffold". Journal of Clinical Rehabilitative Tissue Engineering Research 12 10 (2008): 1815-1818. http://www.scopus.com/inward/record.url?eid=2-s2.0-44249111016&partnerID=MN8TOARS.
  30. Zhang, S.-H.; Zhu, L.-X.; Jin, A.-M.; Yan, L.-P.; Huang, R.; Wang, J.-X.; Zhu, S.-T.. "In vitro culture of chondrocytes on the layered cylindric collagen/chitosan/beta-tricalcium phosphate composite scaffold". Journal of Clinical Rehabilitative Tissue Engineering Research 12 41 (2008): 8033-8036. http://www.scopus.com/inward/record.url?eid=2-s2.0-57849144237&partnerID=MN8TOARS.
Tese / Dissertação
  1. Yan, Leping. "Silk fibroin-based scaffolds, hydrogels and calcium-phosphate filled materials aimed for regenerative medicine applications". Doutoramento, 2014. http://hdl.handle.net/1822/34729.
Atividades

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2020/09/01 - 2025/07/01 Development of immunomodulatory biomaterials for chronic wound healing
Orientador
The Seventh Affiliated Hospital Sun Yat-sen University, China
2019/09/01 - 2024/07/01 Development of novel cell-penetrating peptides for gene therapy to improve diabetic wound healing
Coorientador
The Seventh Affiliated Hospital Sun Yat-sen University, China
2019/09/01 - 2022/07/01 Development of pro-angiogenic hydrogels for improved wound healing
Coorientador
The Seventh Affiliated Hospital Sun Yat-sen University, China

Arbitragem científica em revista

Nome da revista (ISSN) Editora
2021/05/01 - Atual In Vitro Models Springer Nature
Distinções

Prémio

2016 2015 Acta Student Award
Acta Materialia Inc, Estados Unidos