???global.info.a_carregar???
Bárbara B. Mendes obtained a BsC in Biomedical Sciences (2012) from Beira Interior University and a MsC in Biomedical Engineering (2014) from University of Oporto. In July 2020, Bárbara B. Mendes successfully defended her PhD on Tissue Engineering and Biomaterials from 3B's group at Minho University in collaboration with Prof. Jason Burdick at University of Pennsylvania (USA). She have acquired expertise on engineering intrinsically bioactive biomaterials as mimics of the native extracellular matrix. At the moment, the main outcomes of her research work are (1) throve blood derivatives-based biomaterials as modular extracellular matrix-mimetic scaffolds; (2) exploited human-based nanocomposite systems to meet personalized and complex 3D in vitro models conferring tissue-specific roles to the engineered scaffolds. In particular, hierarchical fibrillar network, mechanical properties (e.g., through cellulose nanocrystals content variation), and protein-engineered microenvironment (e.g., via native cell binding motifs and/or selective presentation of platelet derived-proteins). At her current postdoc fellowship, she has been profiling breast tumor heterogeneity in a cell-by-cell approach by designing logic synthetic gene circuits as a biobarcode of multicolor RNA circuits that will be efficient delivered to breast tumor microenvironment using bioresponsive nanohydrogels. The developed platform will be explored to evaluate pre-clinical nanomedicine therapy outcomes in a patient-by-patient basis. As a PhD student, she published 10 articles (6 as first-author) in renowned peer-reviewed journals (Biofabrication, Acta Biomaterialia, Advanced Drug Delivery Reviews), 1 book chapter, 1 international patent granted, and she orally presented in the most important conferences of the field, such as BMES'19, ESB'18, and TERMIS'17. As a junior researcher, from Oct 2020, she published 12 papers (7 as first author, 1 as corresponding author – ALL INDEPENDENT of her PhD collaborators, 2 papers just accepted); 2 journal covers; 3 patents (2 patents submitted, 1 in preparation); I presented 1 invited-talk; 1 invited-workshop; and 3 oral presentations with 73 citations. She is co-supervisor of 1 BSc, 1 MSc, and 1 PhD student (2nd year). She acquired animal FELASA certification (2022). She is a team member in EIC project (€2.5 M) and ERC ‘GelGeneCircuit’ project (€1.5 M). Finally, she is the PI of a FCT-funded exploratory project (€50 K) on 3D lung cancer models (2023). From July 2023 to December 2023, she was in maternity leave. Her h-index is 12/13 (Scopus/Scholar) with over 632/773citations (Scopus/Scholar) - Updated at 16.04.2024.
Identificação

Identificação pessoal

Nome completo
Bárbara Mendes

Nomes de citação

  • Mendes, Bárbara
  • Bárbara B. Mendes

Identificadores de autor

Ciência ID
BD10-2F99-9DD9
ORCID iD
0000-0001-8630-1119

Websites

Domínios de atuação

  • Ciências Médicas e da Saúde - Biotecnologia Médica - Tecnologias que envolvem a Manipulação de Células,Tecidos,Órgãos ou todo o Organismo
  • Ciências da Engenharia e Tecnologias - Nanotecnologia - Nanomateriais
  • Ciências Médicas e da Saúde - Biotecnologia Médica - Biomateriais
  • Ciências da Engenharia e Tecnologias - Biotecnologia Industrial - Bioprodutos Biomateriais
  • Ciências Médicas e da Saúde - Biotecnologia Médica - Diagnóstico e Terapias de Base Genética

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Português (Idioma materno)
Espanhol; Castelhano Utilizador independente (B1) Utilizador independente (B1) Utilizador independente (B1) Utilizador independente (B2) Utilizador independente (B1)
Formação
Grau Classificação
2022/01 - 2022/02
Concluído
Curso Pós-Graduado de Experimentação Animal (Teórico e Prático) - 7ª Edição (Pós-Graduação)
Especialização em Experimentação Animal
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2021/05/10 - 2021/05/17
Frequentou
3rd FLxFlow Course (Outros)
Fundação Champalimaud, Portugal

Instituto Gulbenkian de Ciência, Portugal

Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal

Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
2015/09/01 - 2020/07/24
Concluído
Engenharia de Tecidos, Medicina Regenerativa e Células Estaminais (Doutoramento)
Universidade do Minho - Instituto de Investigação em Biomateriais, Biodegradáveis, Biomiméticos;, Portugal
"Micro/Nano-structured hydrogels based on platelet lysate for tissue engineering and regeneration" (TESE/DISSERTAÇÃO)
Very good with unanimity
2012/09/01 - 2014/10/15
Concluído
Engenharia Biomédica (Mestrado)
Universidade do Porto, Portugal
"Development and characterization of a co-culture two-dimensional blood-brain barrier for the study of nanoparticle permeation." (TESE/DISSERTAÇÃO)
17 valores
2009 - 2012
Concluído
Ciências Biomédicas (Licenciatura)
Universidade da Beira Interior, Portugal
"n/a" (TESE/DISSERTAÇÃO)
15 valores
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento
Empregador
2020/10/01 - Atual Investigador Contratado (Investigação) Universidade Nova de Lisboa, Portugal
Universidade Nova de Lisboa, Portugal
2019/02 - 2019/08 Investigador visitante (Investigação) University of Pennsylvania Department of Bioengineering, Estados Unidos
University of Pennsylvania Department of Bioengineering, Estados Unidos

Cargos e Funções

Categoria Profissional
Instituição de acolhimento
Empregador
2024/02 - Atual Scientific Committee of Histology Facility at NMS Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2020/10 - 2021/10 Elected member of Postdoc Committee as representative of the Postdoc at CEDOC and Toxomics Universidade Nova de Lisboa, Portugal
2018 - 2019 Elected member of 3Bs Institute Council as representative of the PhD students I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics of University of Minho, Portugal, Portugal
Projetos

Bolsa

Designação Financiadores
2020/10/01 - Atual Cancer heterogeneity and therapy profiling using bioresponsive nanohydrogels for the delivery of multicolor logic genetic circuits
Investigador
Universidade Nova de Lisboa, Portugal
European Research Council
Em curso
2015/09 - 2019/08 PhD scholarship - Micro/Nano-structured hydrogels based on platelet lysate for tissue engineering and regeneration
PD/BD/113807/2015
Bolseiro de Doutoramento
Universidade do Minho, Portugal
Fundação para a Ciência e a Tecnologia
Concluído

Projeto

Designação Financiadores
2025/03 - Atual Innovative RANK Signaling Inhibition in Breast Cancer Using Folate-Targeted Lipid Nanoparticles
not apply
Membro da equipa
Gilead Foundation
Em curso
2025/03 - 2027/03 BECAME – BrEast CAncer MicroEnvironment-mimetic platform for Evaluating personalized anticancer agents
not apply
Investigador responsável
Liga Portuguesa Contra o Cancro
Em curso
2023/01/01 - 2024/06/30 Organoides de tumores de pulmão para recriação do fenómeno da disseminação do tumor por via respiratória
2022.07775.PTDC
Investigador responsável
Universidade NOVA de Lisboa, Portugal

FCiênciasID Associação para a Investigação e Desenvolvimento de Ciências, Portugal

Centro Hospitalar Universitário de Lisboa Central EPE, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2019/01/01 - 2019/12/31 ICVS/3B¿s - Laboratório Associado, Instituto de Ciências da Vida e da Saúde / Grupo de Investigação em Biomateriais, Biodegradaveis e Biomiméticos
UID/Multi/50026/2019
Universidade do Minho, Portugal

Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Fundação para a Ciência e a Tecnologia
Concluído

Outro

Designação Financiadores
2023 - Atual GENERA - A revolutionary, highly versatile drug delivery platform based on Metal-Organic Frameworks
Desenvolvimento técnico
European Innovation Council
Em curso
2019 - 2025 InjecTE - Injectable biomaterials for dental tissue engineering.
287953
Desenvolvimento técnico
Universidade do Minho - Instituto de Investigação em Biomateriais, Biodegradáveis, Biomiméticos;, Portugal
Norges forskningsråd
Em curso
2018 - 2023 MagTendon - Magnetic tissue engineering approaches for tendon regeneration.
772817
Desenvolvimento técnico
Universidade do Minho - Instituto de Investigação em Biomateriais, Biodegradáveis, Biomiméticos;, Portugal
European Research Council
Em curso
2018 - 2020 Nanoplant - Nanopatterned dental implants to enhance soft tissue integration and reduce bacterial colonization.
1306_2018
Desenvolvimento técnico
Universidade do Minho - Instituto de Investigação em Biomateriais, Biodegradáveis, Biomiméticos;, Portugal
ITI Stiftung für Orale Implantologie und deren Grenzgebiete
Concluído
2011/07 - 2014/06 InVitroBrain - Development of a humanized dynamic in vitro blood-brain barrier model and a vesicle-based barrier for brain penetration of drugs incorporated in lipid nanoparticles - Closing the gap between in vivo and in vitro properties
Desenvolvimento técnico
Fundação para a Ciência e a Tecnologia
Concluído
Produções

Publicações

Artigo em conferência
  1. Mendes, B.B.; Gómez-Florit, M.; Randall, L.; Babo, P.S.; Almeida, R.C.; Detamore, M.S.; Domingues, R.M.A.; Reis, R.L.; Gomes, M.E.. "Human-based nanocomposite cryogels for hemostatic and wound healing applications". 2019.
  2. Silva, Elsa; Babo, Pedro; Costa-Almeida, Raquel; Domingues, Rui M. A.; Bárbara B. Mendes; Granja, Pedro L.; Manuela E. Gomes. "Multifunctional magnetic-responsive hydrogels modulate platelet lysate-derived growth factor release and guide cell fate.". Trabalho apresentado em Personalized Therapies for Regenerative Medicine, Davos, 2017.
    Publicado
  3. Marques, Claudia; Azevedo, Ana Rita; Carvalho, Isabel; Bárbara B. Mendes; Ferreira, M.; Ferreira, G.; Moreira, A. R.; et al. "Solid lipid nanoparticles as carriers for camptothecin delivery to brain tumor using an in vitro blood brain barrier model.". Trabalho apresentado em 51st Congress of the European Societies of Toxicology (EUROTOX), Porto, 2015.
    Aceite para publicação
  4. Sarmento, Bruno; Marques, Claudia; Azevedo, Ana Rita; Carvalho, Isabel; Mendes, Bárbara; Moreira, Gabriela; Moreira, Ana Rita; Costa, Paulo; Ferreira, Domingos. "Solid lipid nanoparticles as carriers for camptothecin delivery to brain tumor using an in vitro blood brain barrier model. Toxicity, permeability and inflammatory studies". Trabalho apresentado em Toxicology Letters, 2015.
    Publicado
Artigo em revista
  1. Melle, Francesca; Menon, Dhruv; Conniot, João; Ostolaza-Paraiso, Jon; Mercado, Sergio; Oliveira, Jhenifer; Chen, Xu; et al. "Rational Design of Metal–Organic Frameworks for Pancreatic Cancer Therapy: from Machine Learning Screening to In Vivo Efficacy". Advanced Materials (2025): https://doi.org/10.1002/adma.202412757.
    10.1002/adma.202412757
  2. Rajendra Prasad; Arnab Ghosh; Vinay Patel; Berney Peng; Bárbara B. Mendes; Eaint Honey Aung Win; Lucia Gemma Delogu; et al. "Voices of Nanomedicine: Blueprint Guidelines for Collaboration in Addressing Global Unmet Medical Needs". ACS Nano (2025): https://doi.org/10.1021/acsnano.4c13513.
    10.1021/acsnano.4c13513
  3. Mendes, Bárbara B.; Conde, João. "The power of nanobot technology in cancer treatment". Matter 7 8 (2024): 2757-2760. https://doi.org/10.1016/j.matt.2024.06.031.
    10.1016/j.matt.2024.06.031
  4. Rajendra Prasad; Vaskuri G. S. Jyothi; Nagavendra Kommineni; Ravi Teja Bulusu; Bárbara B. Mendes; Jonathan F. Lovell; João Conde. "Biomimetic Ghost Nanomedicine-Based Optotheranostics for Cancer". Nano Letters (2024): https://doi.org/10.1021/acs.nanolett.4c01534.
    10.1021/acs.nanolett.4c01534
  5. Fatima Hameedat; Bárbara B. Mendes; João Conniot; Leonardo D. Di Filippo; Marlus Chorilli; Avi Schroeder; João Conde; Flávia Sousa. "Engineering nanomaterials for glioblastoma nanovaccination". Nature Reviews Materials (2024): https://doi.org/10.1038/s41578-024-00684-z.
    10.1038/s41578-024-00684-z
  6. Bárbara B. Mendes; Zilu Zhang; João Conniot; Diana P. Sousa; João M. J. M. Ravasco; Lauren A. Onweller; Andzelika Lorenc; et al. "A large-scale machine learning analysis of inorganic nanoparticles in preclinical cancer research". Nature Nanotechnology (2024): https://doi.org/10.1038/s41565-024-01673-7.
    10.1038/s41565-024-01673-7
  7. Calado, Rita D.A.; Mendes, Bárbara B.; Conniot, João; Ravasco, João M.J.M.; Sobral, Daniel; Ferreira, Carolina; Ferreira, Rita; et al. "Preclinical assessment of an antibiotic-free cationic surfactant-based cellulose hydrogel for sexually and perinatally transmitted infections". Matter (2024): http://dx.doi.org/10.1016/j.matt.2024.04.002.
    10.1016/j.matt.2024.04.002
  8. Prasad, Rajendra; Peng, Berney; Mendes, Bárbara B.; Kilian, Hailey I.; Gorain, Mahadeo; Zhang, Huijuan; Kundu, Gopal Chandra; et al. "Biomimetic bright optotheranostics for metastasis monitoring and multimodal image-guided breast cancer therapeutics". Journal of Controlled Release 367 (2024): 300-315. http://dx.doi.org/10.1016/j.jconrel.2024.01.056.
    10.1016/j.jconrel.2024.01.056
  9. Xu Chen; Bárbara B. Mendes; Yunhui Zhuang; João Conniot; Sergio Mercado Argandona; Francesca Melle; Diana P. Sousa; et al. "A Fluorinated BODIPY-Based Zirconium Metal–Organic Framework for In Vivo Enhanced Photodynamic Therapy". Journal of the American Chemical Society (2024): https://doi.org/10.1021/jacs.3c12416.
    10.1021/jacs.3c12416
  10. Prasad, Rajendra; Mendes, Bárbara B.; Gorain, Mahadeo; Chandra Kundu, Gopal; Gupta, Narendra; Peng, Berney; Aung Win, Eaint Honey; Qing, He; Conde, João. "Bioinspired and biomimetic cancer-cell-derived membrane nanovesicles for preclinical tumor-targeted nanotheranostics". Cell Reports Physical Science 4 11 (2023): 101648. http://dx.doi.org/10.1016/j.xcrp.2023.101648.
    Publicado • 10.1016/j.xcrp.2023.101648
  11. Bárbara B. Mendes; Oliveira, Jhenifer; Conde, João. Autor correspondente: Bárbara B. Mendes. "Biomimetic hydrogel supporting baths as an alternative to initiate and maintain breast tumor-derived organoids culture". MedComm - Biomaterials and Applications (2023):
    Aceite para publicação
  12. Ruibo Zhong; Sepehr Talebian; Bárbara B. Mendes; Gordon Wallace; Robert Langer; João Conde; Jinjun Shi. "Hydrogels for RNA delivery". Nature Materials (2023): https://doi.org/10.1038/s41563-023-01472-w.
    10.1038/s41563-023-01472-w
  13. sepehr talebian; Bárbara Mendes; João Conniot; Syamak Farajikhah; Fariba Dehghani; Zhongyan Li; Diogo Bitoque; et al. "Biopolymeric Coatings for Local Release of Therapeutics from Biomedical Implants". Advanced Science (2023): 2207603-2207603. http://dx.doi.org/10.1002/advs.202207603.
    Publicado • 10.1002/advs.202207603
  14. Liyi Fu; Yang Zhang; Ryan A. Farokhzad; Bárbara B. Mendes; João Conde; Jinjun Shi. "‘Passive’ nanoparticles for organ-selective systemic delivery: design, mechanism and perspective". Chemical Society Reviews (2023): https://doi.org/10.1039/D2CS00998F.
    10.1039/D2CS00998F
  15. Bárbara B. Mendes; Conniot, João; Avital, Aviram; Yao, Dongbao; Jiang, Xingya; Zhou, Xiang; Sharf-Pauker, Noga; et al. "Nanodelivery of nucleic acids". Nature Reviews Methods Primers 2 1 (2022): http://dx.doi.org/10.1038/s43586-022-00104-y.
    10.1038/s43586-022-00104-y
  16. Lorenc, Andzelika; Mendes, Bárbara B.; Conniot, João; Sousa, Diana P.; Conde, João; Rodrigues, Tiago. "Machine learning for next-generation nanotechnology in healthcare". Matter 4 10 (2021): 3078-3080. http://dx.doi.org/10.1016/j.matt.2021.09.014.
    10.1016/j.matt.2021.09.014
  17. Bárbara B. Mendes; Diana P. Sousa; João Conniot; João Conde. "Nanomedicine-based strategies to target and modulate the tumor microenvironment". Trends in Cancer (2021): https://doi.org/10.1016/j.trecan.2021.05.001.
    10.1016/j.trecan.2021.05.001
  18. Adriana Vilaça; Rui M. A. Domingues; Hanna Tiainen; Bárbara B. Mendes; Alejandro Barrantes; Rui L. Reis; Manuela E. Gomes; Manuel Gomez-Florit. "Multifunctional Surfaces for Improving Soft Tissue Integration". Advanced Healthcare Materials (2021): https://doi.org/10.1002/adhm.202001985.
    10.1002/adhm.202001985
  19. Bárbara B. Mendes; Andrew C. Daly; Rui L. Reis; Rui M.A. Domingues; Manuela E. Gomes; Jason A. Burdick. "Injectable hyaluronic acid and platelet lysate-derived granular hydrogels for biomedical applications". Acta Biomaterialia (2020): https://doi.org/10.1016/j.actbio.2020.10.040.
    10.1016/j.actbio.2020.10.040
  20. Bárbara B. Mendes. "Intrinsically Bioactive Cryogels Based on Platelet Lysate Nanocomposites for Hemostasis Applications". Biomacromolecules (2020): http://dx.doi.org/10.1021/acs.biomac.0c00787.
    10.1021/acs.biomac.0c00787
  21. Bárbara B. Mendes; Manuel Gómez-Florit; Hugo Osório; Adriana Vilaça; Rui M. A. Domingues; Rui L. Reis; Manuela E. Gomes. "Cellulose nanocrystals of variable sulfation degrees can sequester specific platelet lysate-derived biomolecules to modulate stem cell response". Chemical Communications (2020): https://doi.org/10.1039/D0CC01850C.
    10.1039/D0CC01850C
  22. Mendes, Bárbara B; Gómez-Florit, Manuel; Hamilton, Alex G; Detamore, Michael S; Domingues, Rui M A; Reis, Rui L; Gomes, Manuela E. "Human platelet lysate-based nanocomposite bioink for bioprinting hierarchical fibrillar structures". Biofabrication 12 1 (2019): 015012. http://dx.doi.org/10.1088/1758-5090/ab33e8.
    Publicado • 10.1088/1758-5090/ab33e8
  23. Araújo-Custódio, Sandra; Gomez-Florit, Manuel; Tomás, Ana R.; Mendes, Bárbara B.; Babo, Pedro S.; Mithieux, Suzanne M.; Weiss, Anthony; et al. "Injectable and Magnetic Responsive Hydrogels with Bioinspired Ordered Structures". ACS Biomaterials Science & Engineering 5 3 (2019): 1392-1404. http://dx.doi.org/10.1021/acsbiomaterials.8b01179.
    Publicado • 10.1021/acsbiomaterials.8b01179
  24. Silva, Elsa D.; Babo, Pedro S.; Costa-Almeida, Raquel; Domingues, Rui M.A.; Mendes, Bárbara B.; Paz, Elvira; Freitas, Paulo; et al. "Multifunctional magnetic-responsive hydrogels to engineer tendon-to-bone interface". Nanomedicine: Nanotechnology, Biology and Medicine 14 7 (2018): 2375-2385. http://dx.doi.org/10.1016/j.nano.2017.06.002.
    10.1016/j.nano.2017.06.002
  25. Mendes, Bárbara B.; Gómez-Florit, Manuel; Babo, Pedro S.; Domingues, Rui M.; Reis, Rui L.; Gomes, Manuela E.. "Blood derivatives awaken in regenerative medicine strategies to modulate wound healing". Advanced Drug Delivery Reviews 129 (2018): 376-393. http://dx.doi.org/10.1016/j.addr.2017.12.018.
    Publicado • 10.1016/j.addr.2017.12.018
  26. Tamagno Pesqueira; Raquel Costa-Almeida; Suzanne M. Mithieux; Pedro S. Babo; Albina R. Franco; Bárbara B. Mendes; Rui M. A. Domingues; et al. "Engineering magnetically responsive tropoelastin spongy-like hydrogels for soft tissue regeneration". Journal of Materials Chemistry B 6 7 (2018): 1066-1075. https://doi.org/10.1039/C7TB02035J.
    Publicado • 10.1039/C7TB02035J
  27. Mendes, B.B.; Gómez-Florit, M.; Pires, R.A.; Domingues, R.M.A.; Reis, R.L.; Gomes, M.E.. "Human-based fibrillar nanocomposite hydrogels as bioinstructive matrices to tune stem cell behavior". Nanoscale 10 36 (2018): 17388-17401. http://www.scopus.com/inward/record.url?eid=2-s2.0-85059804414&partnerID=MN8TOARS.
    Publicado • 10.1039/c8nr04273j
  28. Mendes, Bárbara; Marques, Cláudia; Carvalho, Isabel; Costa, Paulo; Martins, Susana; Ferreira, Domingos; Sarmento, Bruno. "Influence of glioma cells on a new co-culture in vitro blood brain barrier model for characterization and validation of permeability". International Journal of Pharmaceutics 490 1-2 (2015): 94-101. http://dx.doi.org/10.1016/j.ijpharm.2015.05.027.
    Publicado • 10.1016/j.ijpharm.2015.05.027
Capítulo de livro
  1. Gomez-Florit, Manuel; Domingues, Rui M. A.; Bakht, Syeda Mahwish; Bárbara B. Mendes; Reis, Rui L.; Manuela E. Gomes. "Chapter 1.3.6. Natural Materials". In Biomaterials Science: An Introduction to Materials in Medicine, editado por William Wagner; Shelly Sakiyama-Elbert; Guigen Zhang; Michael Yaszemski. Elsevier, 2020.
    Publicado
  2. Gomes, Maria João; Mendes, Bárbara; Martins, Susana; Sarmento, Bruno. "Nanoparticle Functionalization for Brain Targeting Drug Delivery and Diagnostic". In Handbook of Nanoparticles, 941-959. Springer International Publishing, 2016.
    Publicado • 10.1007/978-3-319-15338-4_42
  3. Gomes, M.J.; Mendes, B.; Martins, S.; Sarmento, B.. "Cell-based in vitro models for studying blood-brain barrier (BBB) permeability". 169-188. 2016.
  4. Gomes, M.J.; Mendes, B.; Martins, S.; Sarmento, B.. "Nanoparticle functionalization for brain targeting drug delivery and diagnostic". 941-959. 2015.
Poster em conferência
  1. Bárbara B. Mendes. "Rheological Tests for the Optimization of Bioink Composition and Printing Parameters in Tissue 3D-Printing.". Trabalho apresentado em IBEREO 2024, 2024.
    https://doi.org/10.1007/978-3-031-67217-0_19
  2. yasmina orraca; Bárbara B. Mendes; Amaral-Silva, Daniela; Conniot, João; Conde, João; helena soares. "Natural-based photocrosslinkable hydrogels for rheumatoid arthritis treatment". Trabalho apresentado em NMS PhD retreat, 2022.
  3. Syeda Mahwish Bakht; Lamers, Tara; Sixt, Milan; Gomez-Florit, Manuel; Bárbara B. Mendes; Reis, R. L.; Domingues, Rui M. A.; Gomes, Manuela E. "3D Printing/Bioprinting of Miniaturized Tissues Embedded in Self-Assembled Nanoparticle-based Fibrillar Platforms". Trabalho apresentado em TERMIS EU 2020, 2020.
  4. Bárbara B. Mendes. "Cellulose nanocrystals of variable sulfation degree for sequestering specific growth factors". Trabalho apresentado em TERMSTEM 2019, 2019.
  5. Bakht, Syeda Mahwish; Lamers, Tara; Gomez-Florit, Manuel; Sixt, Milan; Bárbara B. Mendes; Reis, Rui L.; Domingues, Rui M. A.; Manuela E. Gomes. "Combining 3D Printing with Nanoparticles Self-Assembly for the Fabrication of Fibrillar, Perfusable and Transparent Microfluidics Devices". Trabalho apresentado em 1st Discoveries Forum on regenerative and precision medicine., 2019.
  6. Bárbara B. Mendes; Gomez-Florit, Manuel; Randall, Lindsey; Babo, Pedro; Costa-Almeida, Raquel; Detamore, Michael S.; Domingues, Rui M. A.; Reis, Rui L.; Manuela E. Gomes. "Intrinsically bioactive cryogels for hemorrhage hemostasis and regenerative wound healing applications.". Trabalho apresentado em 30th Annual Meeting of the European Society for Biomaterials., 2019.
  7. Bárbara B. Mendes; Gomez-Florit, Manuel; Randall, Lindsey; Babo, Pedro; Costa-Almeida, Raquel; Detamore, Michael S; Domingues, Rui M. A.; Reis, Rui L.; Manuela E. Gomes. "Human-based hemostatic cryogels for wound healing applications.". Trabalho apresentado em CHEM2Nature – Final Conference, 2018.
  8. Domingues, Rui M. A.; Araújo-Custódio, Sandra; Tomás, A.; Bárbara B. Mendes; Gomez-Florit, Manuel; Babo, Pedro; Reis, Rui L.; Manuela E. Gomes. "Injectable and Magnetic Responsive Hydrogels with Bioinspired Ordered Structures for the Regeneration of Anisotropic Tissues". Trabalho apresentado em 29th Annual Meeting of the European Society for Biomaterials., 2018.
  9. Domingues, Rui M. A.; Araújo-Custódio, Sandra; Bárbara B. Mendes; Gomez-Florit, Manuel; Babo, Pedro; Reis, Rui L.; Manuela E. Gomes. "Cellulose nanocrystals as nanostructuring tools to modulate the artificial cell microenvironment in nanocomposite hydrogels". Trabalho apresentado em 5TH World TERMIS congress 2018, 2018.
  10. Gomez-Florit, Manuel; Bárbara B. Mendes; Domingues, Rui M. A.; Reis, Rui L.; Manuela E. Gomes. "Platelet Lysate-based Nanocomposite Bioink for 3D Printing in Tissue Engineering". Trabalho apresentado em 5TH World TERMIS congress 2018., 2018.
  11. Bárbara B. Mendes; Domingues, Rui M. A.; Reis, Rui L.; Manuela E. Gomes. "Human-based nanocomposite scaffolds towards new bioinstructive matrices to TERM strategies". Trabalho apresentado em Encontro de Ciência, 2018., 2018.
  12. Bakht, Syeda Mahwish; Domingues, Rui M. A.; Bárbara B. Mendes; Reis, Rui L.; Manuela E. Gomes. "Development of tunable supramolecular nanocomposite hydrogels as nanoinks for tissue specific needs in bioprinting". Trabalho apresentado em FORECAST 2017, 2017.
  13. Bárbara B. Mendes; Gomez-Florit, Manuel; Domingues, Rui M. A.; Reis, Rui L.; Manuela E. Gomes. "Platelet lysate loaded in nanocomposite bioinks towards a new generation of bioinks for TERM strategy". Trabalho apresentado em Forecast 2017, 2017.
  14. Gomez-Florit, Manuel; Bárbara B. Mendes; Domingues, Rui M. A.; Reis, Rui L.; Manuela E. Gomes. "Tunable Nanocomposite Bioactive Bioinks for 3D Printing in Tissue Engineering". Trabalho apresentado em 28th Annual Conference of the European Society for Biomaterials (ESB), 2017.
  15. Gomez-Florit, Manuel; Bárbara B. Mendes; Domingues, Rui M. A.; Reis, Rui L.; Manuela E. Gomes. "Research road map towards the development of scaffolds for tendon tissue engineering.". Trabalho apresentado em CHEM2Nature - Second School., 2017.
  16. Bárbara B. Mendes; Costa-Almeida, Raquel; Babo, Pedro; Domingues, Rui M. A.; Reis, Rui L.; Manuela E. Gomes. "Platelet lysate hydrogels enriched with oxidized cellulose nanocrystals.". Trabalho apresentado em TERM STEM 2016, 2016.
  17. Silva, Elsa; Babo, Pedro; Costa-Almeida, Raquel; Domingues, Rui M. A.; Bárbara B. Mendes; Granja, Pedro L.; Manuela E. Gomes. "Multifunctional magnetic-responsive hydrogels to engineer tendon-to-bone interface.". Trabalho apresentado em TERM STEM 2016, 2016.
  18. Marques, Claudia; Bárbara B. Mendes; Azevedo, A. R.; Costa, Paulo; Martins, Susana; Sarmento, Bruno; Ferreira, Domingos. "Drug loaded-lipid nanoparticles as carriers for drug delivery to glioma using an in vitro blood brain barrier model.". Trabalho apresentado em 11th International Conference on Nanosciences & Nanotechnologies, 2014.
  19. Marques, Claudia; Mendes, Bárbara; Azevedo, Ana Rita; Costa, Paulo; Martins, Susana; Ferreira, Domingos; Sarmento, Bruno. "Drug loaded-lipid nanoparticles as carriers for drug delivery to gliomas using an in vitro blood brain barrier model". Trabalho apresentado em 11th International Conference on Nanosciences & Nanotechnologies (NN14), 2014.
  20. Bárbara B. Mendes; Marques, Claudia; Costa, Paulo; Martins, Susana; Ferreira, Domingos; Sarmento, Bruno. "Development of an in vitro Blood-Brain Barrier model for drug-loaded solid lipid nanoparticles delivery". Trabalho apresentado em 5th International Conference on Advanced Nanomedicine., 2014.
  21. Bárbara B. Mendes; Marques, Claudia; Costa, Paulo; Martins, Susana; Ferreira, Domingos; Sarmento, Bruno. "Development and characterization of a co-culture two-dimensional blood-brain barrier for the study and correlation of drug permeation.". Trabalho apresentado em 7th meeting of new investigators of Porto University, 2014.
Tese / Dissertação
  1. Bárbara B. Mendes. "Micro/Nano-structured hydrogels based on platelet lysate for tissue engineering and regeneration". Doutoramento, Universidade do Minho, 2020.
  2. Bárbara Bruna da Silva Mendes. "Development and characterization of a co-culture two-dimensional blood-brain barrier for the study of nanoparticle permeation". Mestrado, 2014. https://repositorio-aberto.up.pt/handle/10216/89528.

Propriedade Intelectual

Patente
  1. Bárbara B. Mendes; Domingues, Rui M. A.; Babo, Pedro; Reis, Rui L.; Manuela E. Gomes. 2017. "Blood derivatives composite material, methods of production and uses thereof.". Portugal.
    Concedida/Emitida
Pedido provisório de patente
  1. 2025. "SURFACTANT-BASED HYDROGEL, METHODS AND USES THEREOF".
    Protegido
  2. 2024. "Inorganic nanoparticles to maximize the efficacy of photodynamic therapies for breast cancer".
    Protegido

Outros

Outra produção
  1. Hydrogels for RNA delivery. Nature Materials Reviews - Cover image.. 2023. Bárbara B. Mendes. https://doi.org/10.1038/s41563-023-01472-w.
  2. Nanodelivery of nucleic acids. Nature Reviews Methods Primers - PrimeView. 2022. Bárbara B. Mendes.
    https://doi.org/10.1038/s43586-022-00115-9
  3. Trends in Cancer Cover image. 2021. Bárbara B. Mendes; Conde, João; Diana P. Sousa; Conniot, João.
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2022/10/20 In vitro recapitulation of breast tumor microenvironment for personalized theranostic strategies NMS PhD retreat
Nova Medical School
2022/05/18 Novel nanoplatforms for imaging and targeting the breast tumor microenvironment Encontro de Ciência e Tecnologia, 2022
Fundação para a Ciência e Tecnologia (Lisboa, Portugal)
2021/11 QAS-hydrogels as a promising microbicide against sexually and perinatal transmitted infections. Microbiotech 2021
Nova University Lisbon
2021/10 Biodegradable polymeric hydrogels as an effective vaginal microbicide delivery system. 3rd NMS symposium
Nova Medical School
2021/09 3D Bioprinting in Self-Assembled Nanoparticles to Fabricate Microphysiological Systems for Tissue/Organ-On-A Chip Applications. European Society for Biomaterials
(Portugal)
2021/09 Multifunctional coatings to improve soft tissue integration of metallic implants. European Society for Biomaterials
2019/11/04 Combining 3D Printing with Nanoparticles Self-Assembly for the Fabrication of Fibrillar, Perfusable and Transparent Microfluidics Devices. Second Achilles Conference
Universidade do Minho - Instituto de Investigação em Biomateriais, Biomiméticos e Biodegradáveis (Braga, Portugal)
2019/10 Platelet Lysate-Based Bioinks for 3D Printing Applications. BMES 2019 Annual Meeting
(Philadelphia, Estados Unidos)
2019/06/12 Platelet Lysate-Based Nanocomposite Biomaterials for Tissue Engineering & Regenerative Medicine. In eCM Online Periodical 2019, Collection 2: Scandinavian Society for Biomaterials 2019 Conference. Page 13. Kirkkonummi, Finland. Scandinavian Society for Biomaterials.
(Kirkkonummi, Finlândia)
2018 Platelet lysate fibrillar nanocomposite bioink for soft tissues bioprinting. European Society for Biomaterials
(Maastritcht, Países Baixos)
2018 Human-based nanocomposite bioink for freeform structures printing. Chem2Nature - Summer School
(Porto, Portugal)
2017/06/26 Injectable platelet lysate/cellulose nanocrystals hydrogels: a novel combined approach for regenerative medicine strategies. In eCM Meeting Abstracts 2017, Collection 2: Personalized Therapies for Regenerative Medicine, TERMIS-EU 2017. 0105. Davos, Switzerland. TERMIS-EU
(Davos, Suiça)
2017 Incorporation of modified cellulose nanocrystals in platelet lysate-based hydrogels for 3D microenvironment sequestration of platelet lysate bioactive molecules. CHEM2Nature - Second School
(Porto, Portugal)
2016/11 Sulfated cellulose nanocrystals: synthesis and application on growth factors sequestering biomaterials. CHEM2Nature - First School
(Guimarães, Portugal)

Orientação

Título / Tema
Papel desempenhado
Curso (Tipo)
Instituição / Organização
2024/09 - Atual Multifunctional nucleic acid-based nanoparticles for profiling breast cancer heterogeneity.
Orientador de Emily Rohrmoser
2024/09 - Atual Profile breast tumour microenvironment heterogeneity using gene circuits-loaded nanoparticles.
Orientador de Rita Rafael
2021/09 - Atual Profiling breast cancer heterogeneity using patient-derived organoids
Coorientador de Jhenifer Oliveira
Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
2024/01 - 2024/06 Development and characterization of tumour spread through air spaces (STAS) phenomenon three-dimensional in vitro model
Orientador de Diogo Dias
BIOLOGIA CELULAR E MOLECULAR (Licenciatura/Bacharelato)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2024/01 - 2024/03 Glioblastoma multiforme targeted delivery of temozolomide using nanostructured lipid carriers
Orientador de Mariana Jardim
Biomedical Engineering (Iniciação científica)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2022/09/01 - 2023/12/11 Development of novel nanoplatforms for the imaging and targeting of breast tumor microenvironment
Orientador de Mariana Pereira
mestrado em oncobiologia (Mestrado)
Universidade do Algarve, Portugal
2023/01/23 - 2023/07 Development of polymeric nanoparticles for Breast Cancer diagnosis, prognosis, and treatment
Orientador
Bioquímica (Licenciatura/Bacharelato)
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação)
Instituição / Organização
2024/05 - 2024/05 Open Day at NMS - 2024 (2024/05 - 2024/05)
Outro (Outra)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2023/05/07 - 2023/05/07 Emerging Technologies on tumor microenvironment biomimetic systems for drug screening| Hands-on Workshop (2023/05 - 2023/05)
Oficina (workshop) (Outra)
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal

TEC2MED, Portugal
2023/05 - 2023/05 Open day NMS -2023 (2023/05 - 2023/05)
Outro (Outra)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2022/05 - 2022/05 Open day NMS - 2022 (2022/05 - 2022/05)
Outro (Outra)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2021/10/11 - 2021/10/13 The CEDOC Post-Doctoral Committee organized the 3rd NMS Symposium on Chronic Diseases and Translational Science from 11th-13th October 2021. The Symposium aims to bring together young and established researchers from Portugal and abroad in a stimulating environment fostering both exchange and generation of new ideas. (2021/10/10 - 2021/10/13)
Conferência (Coorganizador)
Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
2019/11/04 - 2019/11/05 Conference organizing comitee. 04 to 05 November 2019. Second Achilles Conference “Tendon Biophysical Environment”. Braga, Portugal. (2019/11/04 - 2019/11/05)
Conferência (Membro da Comissão Organizadora)
Universidade do Minho - Instituto de Investigação em Biomateriais, Biodegradáveis, Biomiméticos;, Portugal
2018/10/25 - 2018/10/26 CONFERENCE ORGANIZING COMITEE. 25 to 26 October 2018. CHEM2Nature – Final Conference. “Multifunctional Biomaterials Inspired by Nature”. Guimarães, Portugal. (2018/10/25 - 2018/10/26)
Conferência (Membro da Comissão Organizadora)
Universidade do Minho - Instituto de Investigação em Biomateriais, Biodegradáveis, Biomiméticos;, Portugal
2017/11/15 - 2017/11/17 CONFERENCE ORGANIZING COMITEE. 15 to 17 November 2017. Forecast. Porto, Portugal. (2017/11/15 - 2017/11/17)
Conferência (Membro da Comissão Organizadora)
Universidade do Minho - Instituto de Investigação em Biomateriais, Biodegradáveis, Biomiméticos;, Portugal
2016/11/21 - 2016/11/25 CONFERENCE ORGANIZING COMITTEE. 21 to 25 November 2016. CHEM2Nature – First School. Guimarães, Portugal. (2016/11/21 - 2016/11/25)
Conferência (Membro da Comissão Organizadora)
Universidade do Minho - Instituto de Investigação em Biomateriais, Biodegradáveis, Biomiméticos;, Portugal

Participação em evento

Descrição da atividade
Tipo de evento
Nome do evento
Instituição / Organização
2024/02/22 - Atual Interface of engineering and medicine and the path from bench to bedside. With opening remarks anticipated by Columbia Engineering Dean Shih-Fu Chang and Columbia College of Physicians and Surgeons Dean Katrina Armstrong, the symposium comprises four sessions showcasing the role of engineering in the fields of Neuroscience and Biomedical Imaging, Cancer and Genomics, Tissue Engineering and Orthopedic Biomechanics.
Simpósio
Columbia University Irving Medical Center, Estados Unidos
2021/11/08 - 2021/11/12 The participants gain theoretical knowledge and are introduced to protocols and scientific methods related to lysosome and cilia biology, as well as being assisted to solve specific problems.
Oficina (workshop)
LYSOCIL Summer School
Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
2021/10/12 - 2021/10/15 Biology of Cancer: Microenvironment & Metastasis.
Conferência
Sixth Cold Spring Harbor Laboratory meeting
Cold Spring Harbor Laboratory, Estados Unidos
2021/07/21 - 2021/07/22 R3 - Replace, Repair, Regenerate workshop attendance.
Oficina (workshop)
Janelia Research Campus called ¿4D Cellular Physiology : R3 - Replace, Repair, Regenerate
2019/05/04 - 2019/05/04 Philly Motility conference attendance.
Encontro
Philly Motility 2019.
Drexel University, Estados Unidos
2016/11 - 2016/11 B. B. Mendes, Oral presentation: "Orgãos à la Carte", PubhD Uminho, November 2016. STOL - Science Through Our Lives
Universidade do Minho Departamento de Biologia, Portugal

Júri de grau académico

Tema
Tipo de participação
Nome do candidato (Tipo de grau)
Instituição / Organização
2024/11/29 DEVELOPMENT OF 3D-PRINTED CANCER TISSUES USING COMPUTER ASSISTED DESIGNS (CAD)
Arguente principal
Inês Areias Anjos (Mestrado)
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2024/09/20 Novel carbon-based nanoscale therapeutics for the modulation of macrophages in liver inflammation, fibrosis, and regeneration
Arguente
Alazne Moreno Lanceta (Doutoramento)
Universitat de Barcelona Facultat de Medicina i Ciències de la Salut, Espanha
2024/09/04 Macrophage polarization in dermal scaffolds produced from natural polymers
Arguente principal
Ana Filipa Lopes Afonso (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal

Arbitragem científica em revista

Nome da revista (ISSN) Editora
2021 - Atual ACS biomaterials science & engineering. American Chemical Society
2017 - Atual International Journal of Pharmaceutics (0378-5173) Elsevier

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2024/05 - 2024/06 Regeneração de Tecidos Engenharia Biomédica (Mestrado integrado) Instituto Politécnico de Setúbal Escola Superior de Tecnologia de Setúbal, Portugal

Entrevista (jornal / revista)

Descrição da atividade Jornal / Forum
2019 Research highlight "Cells thrive in blood-based bioink" by Physicsworld news journal. Physicsworld news

Entrevista / Programa (rádio / tv)

Programa Tema
2024/11/20 - Atual 90 segundos de Ciência - Podcast Terapias mais eficazes contra o cancro baseados em nanopartículas.

Membro de associação

Nome da associação Tipo de participação
2024/10 - Atual Sociedade Portuguesa de Genética Humana Member
2024 - Atual European Cancer Research Member
2018 - Atual European Society for Biomaterials (ESB) Member of the society.
2019 - 2020 Biomedical Engineering Society (BMES) Member of the society.
2017 - 2018 Tissue Engineering and Regenerative Medicine International Society (TERMIS) Member of the society.

Tutoria

Tópico Nome do aluno
2024/05 - 2024/05 Multilayer hydrogel microneedles for colorectal cancer nanotherapeutics: A combinatory therapy solution Emily Rohrmoser
2022/02 - 2022/06 Profiling breast cancer heterogeneity using polymeric nanoparticles for the delivery of multicolor genetic circuits Ana Maria Cunha
2022/04 - 2022/05 Development of polyplexes as nanocarriers for the delivery od DNA to Breast Cancer Cells Pedro Rosado
2022/01 - 2022/02 Development of polymeric nanoparticles for loading gene therapeutics Carolina Melo
2021/07 - 2021/08 Supervision through their first contact with laboratory equipment and scientific method of work. Beatriz Alves
2021/06 - 2021/07 Development of novel nanoplatforms for the imaging and targeting of breast tumor microenvironment Joana Amorim
2018/09/10 - 2019/02/09 Optimization of Cellulose Nanocrystal hydrogel support baths for high resolution 3D Bioprinting. Milan Sixt
2018/06/03 - 2018/08/03 Characterization of platelet lysate sponges reinforced with oxidized cellulose nanocrystals. Lindsey Randall
2016/08/01 - 2016/08/30 Supervision through their first contact with laboratory equipment and scientific method of work. Miguel Antunes
2016/08/01 - 2016/08/30 Supervision through their first contact with laboratory equipment and scientific method of work. Marisa Monteiro
Distinções

Prémio

2022 Prémio Jovem Universitário de Ourém
Câmara Municipal de Ourém, Portugal
2021 Julia Polak European Doctorate Award 2021
European Society of Biomaterials, França

Outra distinção

2024 Menção Honrosa no Prémio Inovação Bluepharma 2023
Bluepharma, Portugal

Universidade de Coimbra, Portugal
2015 PhD scholarship - PD/BD/113807/2015