John Griffith Jones (B81B-FD5E-E743)

Curriculum Vitae

John Griffith Jones

John Griffith Jones is currently a Senior Researcher in the Center of Neurosciences at the University of Coimbra, Portugal. His longstanding research focus has been the use of stable isotopes and NMR spectroscopy to study metabolic fluxes in different organisms, ranging from yeast to humans. He completed his Ph.D. at the University of Texas at Arlington under the supervision of Dr Edward Bellion, where he applied 13C- and 15N-enriched stable isotope tracers and NMR spectroscopy to study metabolic fluxes in methylotrophic yeast. He then moved to the Lab of Craig Malloy and Dean Sherry at the Department of Radiology at U.T. Southwestern Medical Center in Dallas where he initially studied Krebs cycle fluxes in isolated perfused hearts using the 13C NMR isotopomer analyses and modeling methods that was being developed by this group. He became interested in hepatic Krebs cycle metabolism and contributed to the modeling of futile pyruvate cycling by 13C isotopomer analysis and integrating Krebs cycle flux information with gluconeogenesis by combining the Landau deuterated water measurement of gluconeogenesis with 13C isotopomer analysis After moving to Coimbra, Portugal, he applied this approach for characterizing the nutrient precursors of hepatic glycogen synthesis. Currently, he is developing methods for identifying the nutrient sources of acetyl-CoA for hepatic de novo lipogenesis and fatty acid elongation. Outside of research, he has longstanding passions for fly-fishing, golf and brewing beer.

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Identificação

Identificação pessoal

Nome completo: John Griffith Jones

Nomes de citação

Jones, John

Identificadores de autor

Ciência ID: B81B-FD5E-E743
ORCID iD: 0000-0002-3745-3885

Domínios de atuação

Ciências Médicas e da Saúde - Ciências da Saúde - Nutrição e Dietética

Idiomas

Idioma	Conversação	Leitura	Escrita	Compreensão	Peer-review
Galês (Idioma materno)
Inglês	Utilizador proficiente (C2)	Utilizador proficiente (C2)	Utilizador proficiente (C2)	Utilizador proficiente (C2)	Utilizador proficiente (C2)
Português	Utilizador independente (B2)	Utilizador independente (B2)	Utilizador elementar (A2)	Utilizador independente (B1)	Utilizador independente (B1)

Formação

	Grau	Classificação
1985/09/01 - 1991/05/01 Concluído	Applied Chemistry (Doctor of Philosophy) University of Texas at Arlington, Estados Unidos
1981/09/15 - 1985/05/31 Concluído	Biology and Chemistry (Bachelor) University of Stirling, Reino Unido

Percurso profissional

Ciência

	Categoria Profissional Instituição de acolhimento	Empregador
2025/02/16 - Atual	Investigador principal (carreira) (Investigação)	Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal

1999/01/01 - 2000/10/31	Investigador principal (carreira) (Investigação)	The University of Texas Southwestern Medical Center, Estados Unidos
	The University of Texas Southwestern Medical Center, Estados Unidos
1995/06/01 - 1999/01/01	Investigador Auxiliar (carreira) (Investigação)	The University of Texas Southwestern Medical Center, Estados Unidos
	The University of Texas Southwestern Medical Center, Estados Unidos
1991/06/01 - 1995/05/31	Pós-doutorado (Investigação)	The University of Texas Southwestern Medical Center, Estados Unidos
	The University of Texas Southwestern Medical Center, Estados Unidos

Cargos e Funções

	Categoria Profissional Instituição de acolhimento	Empregador
2002/04/01 - Atual	Principal Investigator - Research	Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
	Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal

Outros

	Categoria Profissional Instituição de acolhimento	Empregador
2000/11/01 - 2001/10/31	Marie Curie Experienced Researcher Fellowship	Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
	Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal

Projetos

Bolsa

	Designação	Financiadores
2026/02/01 - 2027/07/31	Endogenously generated sugars and polyols as predictive markers of Type 2 Diabetes complications CENTRO2030-FEDER-02359500 Investigador responsável Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal	Em curso
2023/06/01 - 2027/05/31	PAS GRAS - de-risking metabolic, environmental and behavioural determinants of obesity in children, adolescents and young adults HORIZON-HLTH-2022-STAYHLTH-01-101080329-2 Co-Investigador Responsável (Co-IR)	EU Framework Programme for Research and Innovation Secure Societies Em curso
2023/10/01 - 2026/09/30	High-sensitivity 13C NMR isotopomer analysis of human liver metabolite enrichment from [U-13C]glucose via a novel chemical biopsy agent: application to metabolic flux profiling of NAFLD and NASH patients P020421 Investigador responsável National High Magnetic Field Laboratory, Estados Unidos	National Science Foundation Em curso
2025/02/20 - 2026/08/19	Measuring hepatic polyol pathway activity and connecting it with lipogenic glucose metabolism in Type 2 Diabetes patients 2023.11517.PEX Investigador responsável	Em curso
2024/01/01 - 2025/12/31	Pentose phosphate pathway and serine oxidation fluxes in NAFLD and NASH 77183119 Investigador responsável Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal	Pfizer Global Research and Development Em curso
2022/01/01 - 2024/12/31	Developing H218O as a tracer of carbohydrate metabolism: Positional analysis of liver glycerol and glycogen 18O-enrichment by isotope-shifted 13C and 31P NMR P19803 Investigador responsável	Concluído
2017/01/01 - 2021/12/31	Metabolism and the Liver-Gut Axis in Non-Alcoholic Fatty Liver Disease H2020-MSCA-RISE-2016-734719 H2020-MSCA-ITN-2016-722619 Co-Investigador Responsável (Co-IR)	European Commission Concluído
2017/01/01 - 2021/12/31	Metabolic dysfunctions associated with pharmacological treatment of Schizophrenia H2020-MSCA-ITN-2016-721236 Co-Investigador Responsável (Co-IR)	EU Framework Programme for Research and Innovation Marie Sklodowska-Curie Actions Concluído
2018/11/01 - 2021/10/31	High-sensitivity 13C NMR isotopomer analysis of triglyceride fatty acid enrichment from [U-13C]fructose P17827 Investigador responsável National High Magnetic Field Laboratory, Estados Unidos	National Science Foundation Concluído
2019/07/01 - 2021/06/30	Coffee protects against NAFLD progression through preservation of intestinal permeability and inhibition of liver fibrosis ISIC Investigador responsável Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	The Institute for Scientific Information on Coffee (ISIC) Concluído
2018/06/01 - 2021/05/31	The Role of Visceral Fructose Metabolism in the Development of Non-alcoholic Fatty Liver Disease 02/SAICT/2017/028147 Investigador responsável Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2019/01 - 2019/12	CNC. IBILI 154730UID UID/NEU/04539/2019 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra, Portugal Universidade de Coimbra, Portugal Universidade de Coimbra Instituto de Ciências Nucleares Aplicadas à Saúde, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2016/05/01 - 2019/04/30	Reducing nitrogenous waste production of farmed seabass by dietary glycerol supplementation PTDC/CVT-NUT/2851/2014 Co-Investigador Responsável (Co-IR)	Fundação para a Ciência e a Tecnologia, I.P. Concluído
2016/01 - 2019/04	Prognostic and Protective Roles of the Clusterin-PON1 axis Against Obesity Complications PTDC/BIM-MET/4265/2014 124913 Provided by PTCRIS: 124913 Co-Investigador Responsável (Co-IR)	Fundação para a Ciência e a Tecnologia, I.P. Concluído
2013/06 - 2016/05	Anticipating diabetes and diabetic wounding for siblings of Type 2 diabetics. 124979 Provided by PTCRIS: 124979 Co-Investigador Responsável (Co-IR)	Fundação para a Ciência e a Tecnologia, I.P. Concluído
2013/04/01 - 2016/03/31	UC NMR: a voyage from chemical space to biological function RECI/QEQ-QFI/0168/2012 Co-Investigador Responsável (Co-IR)	Fundação para a Ciência e a Tecnologia Concluído
2013/01 - 2015/12	Identification and validation of biomarker genes to improve the production of Sparus aurata by optimizing the use of dietary nutrients MICINN AGL2012-33305 Co-Investigador Responsável (Co-IR)	Ministro de Economia e Competitividad Concluído
2014/03 - 2015/09	Ageing@Coimbra: A Co-location Centre in the European Knowledge and Innovation Network for Active and Healthy Ageing grant.Provided by PTCRIS: 135805 EIT-KIC/IVE/0043/2013 Provided by PTCRIS: 135805PRJ Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal Administração Regional de Saúde do Centro IP, Portugal Universidade de Coimbra, Portugal Universidade do Porto Faculdade de Engenharia, Portugal Universidade de Coimbra Faculdade de Medicina, Portugal Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal	Fundação para a Ciência e a Tecnologia Stichting Weten Concluído
2013/08 - 2015/07	The Effect of TCF7L2 on Glucose Metabolism DK 078646-06 Consultant	National Institutes of Health Office of the Director Concluído
2011/07/01 - 2014/06/30	Role of the intestine in promoting the lipogenic effects of fructose PTDC-SAU-MET-111398-2009 Investigador responsável Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2010/04 - 2013/09	Optimizing carbohydrate utilization in farmed sea-bass through metabolic profiling Provided by PTCRIS: 98111 98111 Investigador responsável	Fundação para a Ciência e a Tecnologia, I.P. Concluído
2009/08 - 2012/07	Effect of Transaldolase Enzyme Pathway on Gluconeogenesis in People with Prediabetes DK29953 Consultant	National Institutes of Health Office of the Director Concluído
2007/10 - 2010/12	Disruption of hepatic glucose and lipid metabolism by immunosuppressive agents: implications for diagnosis and treatment of posttransplant diabetes Provided by PTCRIS: 65140 65140 Investigador responsável	Fundação para a Ciência e a Tecnologia, I.P. Concluído
2006/05/01 - 2008/12/31	Noninvasive measurement of hepatic glycogen kinetics in Type 1 diabetics 1-2006-74 Investigador responsável	Juvenile Diabetes Research Foundation International Concluído
2005/09 - 2008/08	Improvement of insulin oral availability through encapsulation in polyelectrolyte complex nanoparticles Provided by PTCRIS: 59940 59940 Collaborator	Fundação para a Ciência e a Tecnologia, I.P. Concluído
2005/10 - 2008/06	Study of the possible environmental and molecular mechanisms responsible for Insulin Resistance, Type 2 Diabetes and Obesity in Portugal 82373 Provided by PTCRIS: 82373 Provided by PTCRIS: 109279 109279 Co-Investigador Responsável (Co-IR)	Fundação para a Ciência e a Tecnologia, I.P. Concluído
2005/10 - 2007/09	Hepatic intermediary metabolism of glucose in children with and without hepatic glucose-6-phosphatase activity POCTI/QUI/55603/2004 Investigador responsável	Fundação para a Ciência e a Tecnologia Concluído
2005/10 - 2007/06	Design of new Vanadium compounds: towards their application as anti-diabetic and anti-cancer agents Provided by PTCRIS: 56949 Collaborator	Fundação para a Ciência e a Tecnologia Concluído
2004/04 - 2005/07	Noninvasive assessment of hepatic glycogen metabolism in Type 1 diabetics 5-2004-306 Investigador responsável	Juvenile Diabetes Research Foundation International Concluído
2000/11/01 - 2001/10/31	MEASUREMENT OF HEPATIC GLUCOSE METABOLISM IN CIRRHOTIC PATIENTS USING STABLE ISOTOPES AND NMR HPMF-CT-2000-00469 Bolseiro de Investigação EU Framework Programme for Research and Innovation Marie Sklodowska-Curie Actions, Bélgica
1991/06/01 - 2000/10/31	Southwestern NMR Center for in Vivo Metabolism P41RR002584 Bolseiro de Integração na Investigação	National Center for Advancing Translational Sciences Concluído

Projeto

	Designação	Financiadores
2025/02/03 - 2026/08/02	Adipocyte Browning: the missing link for peritoneal metastasis in diffuse gastric cancer 2023.11680.PEX 10.54499/2023.11680.PEX Centro Hospitalar Universitário de São João, Portugal Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2023/05/15 - 2026/02/19	Metabolite-activated 3D stem cell differentiation into bone 2022.04286.PTDC 10.54499/2022.04286.PTDC Universidade de Coimbra, Portugal Universidade de Aveiro, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2021/01/01 - 2025/12/31	Centro de Inovação em Biomedicina e Biotecnologia - Laboratório Associado LA/P/0058/2020 10.54499/LA/P/0058/2020 Universidade de Coimbra, Portugal Universidade Nova de Lisboa Laboratório de Instrumentação Engenharia Biomédica e Física da Radiação, Portugal Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2023/03/06 - 2024/09/05	Early biomarkers to stop vascular dysfunction associated with obesity and type 2 diabetes 2022.04526.PTDC 10.54499/2022.04526.PTDC Universidade de Coimbra, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2023/03/01 - 2024/08/31	Different intracellular AMPK pools modulate mitochondria-ER contact sites 2022.04407.PTDC 10.54499/2022.04407.PTDC Universidade de Coimbra, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2018/10/01 - 2021/09/30	Estratificação de doenças metabólicas crónicas: exossomas derivados de eixo hepático-intestinal. PTDC/MEC-MET/29314/2017 Universidade de Aveiro, Portugal Universidade Nova de Lisboa, Portugal Fundação Champalimaud, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2017/10/01 - 2020/09/30	ITN-TREATMENT - Training European Network: Metabolic Dysfunctions associated with Pharmacological Treatment of Schizophrenia H2020-MSCA-ITN-721236 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal BnML Behavioral and Molecular Lab Lda, Portugal NIMGenetics Genómica y Medicina SL, Espanha Universidade de Coimbra, Portugal Univerza v Ljubljani, Eslovénia Instituto de Investigaciones Biomédicas Sols-Morreale, Espanha Uppsala universitet - Campus Gotland, Suécia Hebrew University of Jerusalem The David R Bloom Center for Pharmacy, Israel Universitat de Lleida, Espanha Laboratório Associado ICVS 3B's, Portugal Centro de Investigación Biomédica en Red de Salud Mental, Espanha Anaxomics, Espanha Universidade do Minho, Portugal Hospital Universitario de la Princesa, Espanha	EU Framework Programme for Research and Innovation Marie Sklodowska-Curie Actions Concluído
2019/01/01 - 2019/12/31	Centro de Investigação e de Tecnologias Agro-Ambientais e Biológicas UID/AGR/04033/2019 UID/Multi/00190/2019 154867UID 154694UID Universidade do Porto Faculdade de Ciências, Portugal Universidade do Porto Centro de Investigação em Ciências Geo-Espaciais, Portugal Universidade de Trás-os-Montes e Alto Douro Centro de Investigação e de Tecnologias Agro-Ambientais e Biologicas, Portugal Universidade de Trás-os-Montes e Alto Douro, Portugal Universidade do Minho, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2013/07/01 - 2015/12/31	CD26/DPP4 in Fatty Liver Disease progression: inflammation impinges on dysmetabolism. PTDC/BIM-MET/0486/2012 Associação Protectora dos Diabéticos de Portugal, Portugal Fundação Calouste Gulbenkian, Portugal Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal Universidade Nova de Lisboa Medical School, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2011/07/01 - 2014/12/31	O papel do intestino no desenvolvimento da esteatose hepatica induzida pela frutose PTDC/SAU-MET/111398/2009 Universidade de Coimbra, Portugal Universidade de Aveiro, Portugal Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2011/01/01 - 2012/12/31	Strategic Project - LA 1 - 2011-2012 PEst-C/SAU/LA0001/2011 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2005/09/01 - 2008/08/31	Increasing oral bioavailability of insulin through its nano encapsulation in polysaccharides POCI/SAU-FCF/59940/2004 Universidade de Coimbra, Portugal Cooperativa de Ensino Superior Politécnico e Universitário CRL, Portugal Instituto Universitário de Ciências da Saúde, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2004 - 2007	Development of new vanadium compounds for applications as anti diabetic and anti-cancer agents POCTI/QUI/56949/2004-PPCDT/QUI/56949/2004 POCI/QUI/56949/2004 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal Universidade do Porto Instituto de Ciências Tecnologias e Agroambiente, Portugal Universidade de Lisboa Instituto Superior Técnico, Portugal Universidade de Lisboa Centro de Química Estrutural, Portugal	Fundação para a Ciência e a Tecnologia Concluído

Produções

Publicações

Artigo em revista	Hinrichs, Arne; Pafili, Kalliopi; Sancar, Gencer; Laane, Laeticia; Zettler, Silja; Torgeman, Malek; Kessler, Barbara; et al. "Transient juvenile hypoglycemia in GH insensitive Laron syndrome pigs is associated with insulin hypersensitivity". Molecular Metabolism 103 (2026): 102273. https://doi.org/10.1016/j.molmet.2025.102273. 10.1016/j.molmet.2025.102273 Jones, John. "Metabolic priming alters the morphology and metabolism of human dermal fibroblasts: metabolic shift impacts fibroblast phenotype". EXCLI Journal 24 (2025): 1419-1437. Acesso aberto • Publicado Fernandes, E. A.; Palma, M.; Lente-Silva, A.; Viegas, I.; Jones, J. G.; Lordelo, M. M.; Martins, L. L.; Raymundo, A.; Almeida, A. M.. "Combined Effects of Spirulina (Limnospira platensis) Dietary Inclusion and Heat Stress on the Hepatic and Muscle Metabolomes of Two Strains of Slow-Growth Broilers". ACS Food Science & Technology 5 10 (2025): 3726-3736. https://doi.org/10.1021/acsfoodscitech.5c00332. 10.1021/acsfoodscitech.5c00332 Malik, Afshan N.; Azul, Anabela Marisa; Carvalho, Eugénia; Jones, John G.; Matafome, Paulo; Oliveira, Paulo J.. "Tackling overweight and obesity in the youth with the PAS GRAS project". Nature Medicine 31 7 (2025): 2084-2086. https://doi.org/10.1038/s41591-025-03721-8. 10.1038/s41591-025-03721-8 Fernandes, E. A.; Palma, M.; Lente-Silva, A.; Viegas, I.; Jones, J. G.; Lordelo, M. M.; Martins, L. L.; Raymundo, A.; Almeida, A. M.. "The ¹H NMR-Metabolomics of Hepatic and Muscle Tissues in Two Slow-Growing Broiler Strains Fed Spirulina (Limnospira platensis)". ACS Food Science & Technology 5 6 (2025): 2417-2429. https://doi.org/10.1021/acsfoodscitech.5c00228. 10.1021/acsfoodscitech.5c00228 João G. Silva; Ludgero Tavares; Getachew D. Belew; João A. Rodrigues; Rita Araújo; Ana M. Gil; John G. Jones. "Impact of High-Fat Diet-induced Metabolic Dysfunction-associated Steatotic Liver Disease on Heart, Kidney, and Skeletal Muscle Metabolomes in Wild-Type Mice". Journal of Proteome Research (2025): https://doi.org/10.1021/acs.jproteome.5c00040. 10.1021/acs.jproteome.5c00040 Pinhanços, Sandra Sofia; Teixeira de Oliveira, João; Alves, C. Henrique; Deus, Cláudia M.; de Winter, Twan J.J.; Viana, Sofia; Reis, Flávio; et al. "miRNA-642a-3p protects ß cells from glucolipotoxicity". Molecular Therapy Nucleic Acids (2025): 102498. https://www.cell.com/molecular-therapy-family/nucleic-acids/fulltext/S2162-2531(25)00052-6?uuid=uuid%3A0256c6d1-f9f9-4eda-9c95-a686e77cbfd1. Publicado • 10.1016/j.omtn.2025.102498 Margarida Coelho; João Capela; Vera M. Mendes; João Pacheco; Margarida Sá Fernandes; Isabel Amendoeira; John G. Jones; Luís Raposo; Bruno Manadas. "Peptidomics Unveils Distinct Acetylation Patterns of Histone and Annexin A1 in Differentiated Thyroid Cancer". International Journal of Molecular Sciences (2023): https://doi.org/10.3390/ijms25010376. 10.3390/ijms25010376 Margarida Coelho; João Capela; Sandra I. Anjo; João Pacheco; Margarida Sá Fernandes; Isabel Amendoeira; John G. Jones; Luís Raposo; Bruno Manadas. "Proteomics Reveals mRNA Regulation and the Action of Annexins in Thyroid Cancer". International Journal of Molecular Sciences (2023): https://doi.org/10.3390/ijms241914542. 10.3390/ijms241914542 Vitor Ferreira; Cintia Folgueira; María García-Altares; Maria Guillén; Mónica Ruíz-Rosario; Giada DiNunzio; Irma Garcia-Martinez; et al. "Hypothalamic JNK1-hepatic fatty acid synthase axis mediates a metabolic rewiring that prevents hepatic steatosis in male mice treated with olanzapine via intraperitoneal: Additional effects of PTP1B inhibition". Redox Biology 63 (2023): 102741-102741. http://dx.doi.org/10.1016/j.redox.2023.102741. 10.1016/j.redox.2023.102741 Amorim, Ricardo; Magalhães, Carina; Benfeito, Sofia ; Ludgero Tavares; Santos, Kátia; Sardão, Vilma; Sandipan Datta; et al. "The decyl-TPP mitochondriotropic antioxidant based on caffeic acid AntiOxCIN6 sensitizes lung anticancer therapy due to a remodeling of mitochondrial metabolism and upregulation of energetic glycolytic dependence". Free Radical Biology and Medicine (2023): Submetido João Pessoa; Getachew D. Belew; Cristina Barroso; Conceição Egas; John G. Jones. "The Gut Microbiome Responds Progressively to Fat and/or Sugar-Rich Diets and Is Differentially Modified by Dietary Fat and Sugar". Nutrients (2023): https://doi.org/10.3390/nu15092097. 10.3390/nu15092097 Margarida Coelho; Patarrao RS; Inês Sousa-Lima; Rogério T. Ribeiro; Maria João Meneses; Rita Andrade; Vera M. Mendes; et al. "Increased Intake of Both Caffeine and Non-Caffeine Coffee Components Is Associated with Reduced NAFLD Severity in Subjects with Type 2 Diabetes". Nutrients (2022): https://www.mdpi.com/2072-6643/15/1/4. 10.3390/nu15010004 Ivan Viegas; Giada Di Nunzio; Getachew D. Belew; Alejandra N. Torres; João G. Silva; Luis Perpétuo; Cristina Barosa; Ludgero C. Tavares; John G. Jones. "Integration of Liver Glycogen and Triglyceride NMR Isotopomer Analyses Provides a Comprehensive Coverage of Hepatic Glucose and Fructose Metabolism". Metabolites (2022): https://doi.org/10.3390/metabo12111142. 10.3390/metabo12111142 Getachew Debas Belew; John G. Jones. "De novo lipogenesis in non-alcoholic fatty liver disease: Quantification with stable isotope tracers". European Journal of Clinical Investigation (2022): https://doi.org/10.1111/eci.13733. 10.1111/eci.13733 Coelho, Margarida; Mahar, Rohit; Belew, Getachew D.; Torres, Alejandra; Barosa, Cristina; Cabral, Fernando; Viegas, Ivan; et al. "Enrichment of hepatic glycogen and plasma glucose from (H2O)-O-18 informs gluconeogenic and indirect pathway fluxes in naturally feeding mice". NMR in Biomedicine (2022): https://publons.com/wos-op/publon/54600422/. 10.1002/NBM.4837 Patricio, Joao S.; Dias-Pedroso, Daniela; Carvalho, Rui A.; Viera, Helena L. A.; Jones, John G.. "A simple method for quantifying de novo lipogenesis rate and substrate selection in cell cultures by C-13 NMR isotopomer analysis of the crude lipid fraction". NMR in Biomedicine (2022): https://publons.com/wos-op/publon/50808444/. 10.1002/NBM.4648 Amorim, Ricardo; Cagide, Fernando; Tavares, Ludgero C.; Simoes, Rui F.; Soares, Pedro; Benfeito, Sofia; Baldeiras, Ines; et al. "Mitochondriotropic antioxidant based on caffeic acid AntiOxCIN(4) activates Nrf2-dependent antioxidant defenses and quality control mechanisms to antagonize oxidative stress-induced cell damage". Free Radical Biology and Medicine (2022): https://publons.com/wos-op/publon/51770689/. 10.1016/J.FREERADBIOMED.2021.12.304 Molina-Molina, Emilio; Furtado, Guilherme Eustaquio.; Jones, John G.; Portincasa, Piero; Vieira-Pedrosa, Ana; Teixeira, Ana Maria; Barros, Marcelo Paes; Bachi, Andre Luis Lacerda; Sardao, Vilma A.. "The advantages of physical exercise as a preventive strategy against NAFLD in postmenopausal women". European Journal of Clinical Investigation (2022): https://publons.com/wos-op/publon/49682785/. 10.1111/ECI.13731 Amorim, Ricardo; Simoes, Ines C. M.; Teixeira, Jose; Cagide, Fernando; Potes, Yaiza; Soares, Pedro; Carvalho, Adriana; et al. "Mitochondria-targeted anti-oxidant AntiOxCIN4 improved liver steatosis in Western diet-fed mice by preventing lipid accumulation due to upregulation of fatty acid oxidation, quality control mechanism and antioxidant defense systems". Redox Biology (2022): https://publons.com/wos-op/publon/53932683/. 10.1016/J.REDOX.2022.102400 João S Patrício; Daniela Dias-Pedroso; Daniela Dias-Pedroso; Helena L A Viera; Rui A. Carvalho; Rui A. Carvalho; John G. Jones. "A simple method for quantifying de novo lipogenesis rate and substrate selection in cell cultures by ¹³C NMR isotopomer analysis of the crude lipid fraction". NMR in Biomedicine 35 3 (2021): https://doi.org/10.1002/nbm.4648. 10.1002/nbm.4648 John G. Jones. "Non-Invasive Analysis of Human Liver Metabolism by Magnetic Resonance Spectroscopy". Metabolites 11 11 (2021): 751-751. https://doi.org/10.3390/metabo11110751. 10.3390/metabo11110751 Cristina Barosa; Rogério T. Ribeiro; Rita Andrade; João F. Raposo; John G. Jones. "Effects of Meal Fructose/Glucose Composition on Postprandial Glucose Appearance and Hepatic Glycogen Synthesis in Healthy Subjects". Journal of Clinical Medicine (2021): https://doi.org/10.3390/jcm10040596. 10.3390/jcm10040596 Dias-Pedroso, Daniela; Ramalho, Jose S.; Sardao, Vilma A.; Jones, John G.; Romao, Carlos C.; Oliveira, Paulo J.; Vieira, Helena L. A.. "Carbon Monoxide-Neuroglobin Axis Targeting Metabolism Against Inflammation in BV-2 Microglial Cells". Molecular Neurobiology (2021): https://publons.com/wos-op/publon/50262822/. 10.1007/S12035-021-02630-4 Borges, Diego O.; Patarrao, Rita S.; Ribeiro, Rogerio T.; de Oliveira, Rita Machado; Duarte, Nadia; Belew, Getachew Debas; Martins, Madalena; et al. "Loss of postprandial insulin clearance control by Insulin-degrading enzyme drives dysmetabolism traits". Metabolism (2021): https://publons.com/wos-op/publon/41702324/. 10.1016/J.METABOL.2021.154735 Sousa, Luis; Guarda, Mariana; Meneses, Maria Joao; Macedo, M. Paula; Vicente Miranda, Hugo. "Insulin-degrading enzyme: an ally against metabolic and neurodegenerative diseases". The Journal of Pathology (2021): https://publons.com/wos-op/publon/49707570/. 10.1002/PATH.5777 Laurenti, Marcello C.; Dalla Man, Chiara; Varghese, Ron T.; Andrews, James C.; Jones, John G.; Barosa, Cristina; Rizza, Robert A.; et al. "Insulin Pulse Characteristics and Insulin Action in Non-diabetic Humans". The Journal of Clinical Endocrinology & Metabolism (2021): https://publons.com/wos-op/publon/46827652/. 10.1210/CLINEM/DGAB100 Torres, Alejandra N.; Tavares, Ludgero; Pereira, Maria J.; Eriksson, Jan W.; Jones, John G.. "Positional and compositional analysis of saturated, monounsaturated, and polyunsaturated fatty acids in human adipose tissue triglyceride by C-13 nuclear magnetic resonance". NMR in Biomedicine (2021): https://publons.com/wos-op/publon/50291978/. 10.1002/NBM.4632 Sousa-Lima, Ines; Kim, Hyun Jeong; Jones, John; Kim, Young-Bum. "Rho-Kinase as a Therapeutic Target for Nonalcoholic Fatty Liver Diseases". Diabetes & Metabolism Journal (2021): https://publons.com/wos-op/publon/55608243/. 10.4093/DMJ.2021.0197 Jones, John. "Determining the contribution of a high-fructose corn syrup formulation to hepatic glycogen synthesis during ad-libitum feeding in mice". Scientific Reports (2020): http://dx.doi.org/10.1038/s41598-020-69820-3. 10.1038/s41598-020-69820-3 Getachew D. Belew; Giada Di Nunzio; Ludgero Tavares; Joao G. Silva; Alejandra N. Torres; John G. Jones. "Estimating pentose phosphate pathway activity from the analysis of hepatic glycogen 13 C-isotopomers derived from [U- 13 C]fructose and [U- 13 C]glucose". Magnetic Resonance in Medicine 84 5 (2020): 2765-2771. https://doi.org/10.1002/mrm.28286. 10.1002/mrm.28286 Jones, John. "Metabolic incorporation of H 2 18 O into specific glucose-6-phosphate oxygens by red-blood-cell lysates as observed by 13 C isotope-shifted NMR signals". NMR in Biomedicine (2020): http://dx.doi.org/10.1002/nbm.4395. 10.1002/nbm.4395 Margarida Coelho; Luis Raposo; Brian J. Goodfellow; Luigi Atzori; John Jones; Bruno Manadas. "The Potential of Metabolomics in the Diagnosis of Thyroid Cancer". International Journal of Molecular Sciences 21 15 (2020): 5272-5272. https://doi.org/10.3390/ijms21155272. 10.3390/ijms21155272 Jones, John. "Monounsaturated fat rapidly induces hepatic gluconeogenesis and whole-body insulin resistance". JCI Insight (2020): http://dx.doi.org/10.1172/jci.insight.134520. 10.1172/jci.insight.134520 Jones, John. "Limitations to Starch Utilization in Barramundi (Lates calcarifer) as Revealed by NMR-Based Metabolomics". Frontiers in Physiology (2020): http://dx.doi.org/10.3389/fphys.2020.00205. 10.3389/fphys.2020.00205 Barosa, Cristina; Shanmugam, Harshitha; Cabral, Fernando; Jones, John G.. "p-Aminobenzoic acid as an alternative chemical biopsy agent for human hepatic UDP-glucose". Analytical Biochemistry 590 (2020): 113511. http://dx.doi.org/10.1016/j.ab.2019.113511. 10.1016/j.ab.2019.113511 Getachew Debas Belew; Joao Silva; Joao Rito; Ludgero Tavares; Ivan Viegas; Jose Teixeira; Paulo J. Oliveira; Maria Paula Macedo; John G. Jones. "Transfer of glucose hydrogens via acetyl-CoA, malonyl-CoA, and NADPH to fatty acids during de novo lipogenesis". Journal of Lipid Research 60 12 (2019): 2050-2056. https://doi.org/10.1194/jlr.RA119000354. 10.1194/jlr.RA119000354 Silva, João C.P.; Marques, Cátia; Martins, Fátima O.; Viegas, Ivan; Tavares, Ludgero; Macedo, Maria Paula; Jones, John G.. "Determining contributions of exogenous glucose and fructose to de novo fatty acid and glycerol synthesis in liver and adipose tissue". Metabolic Engineering 56 (2019): 69-76. http://dx.doi.org/10.1016/j.ymben.2019.08.018. 10.1016/j.ymben.2019.08.018 Caroline D. Veloso; Getachew D. Belew; Luciana L. Ferreira; Luís F. Grilo; John G. Jones; Piero Portincasa; Vilma A. Sardão; Paulo J. Oliveira. "A Mitochondrial Approach to Cardiovascular Risk and Disease". Current Pharmaceutical Design 25 29 (2019): 3175-3194. https://doi.org/10.2174/1389203720666190830163735. 10.2174/1389203720666190830163735 Jones, John. "27th Annual Meeting of the European Group for the study of Insulin Resistance, Lisbon, Portugal, 8–9th May 2019". Cardiovascular Endocrinology & Metabolism (2019): http://dx.doi.org/10.1097/xce.0000000000000179. 10.1097/xce.0000000000000179 Jonás I. Silva-Marrero; Juliana Villasante; Ania Rashidpour; Mariana Palma; Anna Fàbregas; María Pilar Almajano; Ivan Viegas; et al. "The Administration of Chitosan-Tripolyphosphate-DNA Nanoparticles to Express Exogenous SREBP1a Enhances Conversion of Dietary Carbohydrates into Lipids in the Liver of Sparus aurata". Biomolecules 9 8 (2019): 297-297. https://doi.org/10.3390/biom9080297. 10.3390/biom9080297 Araújo, Pedro M.; Viegas, Ivan; Rocha, Afonso D.; Villegas, Auxiliadora; Jones, John G.; Mendonça, Liliana; Ramos, Jaime A.; Masero, José A.; Alves, José A.. "Understanding how birds rebuild fat stores during migration: insights from an experimental study". Scientific Reports 9 1 (2019): http://dx.doi.org/10.1038/s41598-019-46487-z. 10.1038/s41598-019-46487-z Viegas, Ivan; Trenkner, Lauren H.; Rito, João; Palma, Mariana; Tavares, Ludgero C.; Jones, John G.; Glencross, Brett D.; Wade, Nicholas M.. "Impact of dietary starch on extrahepatic tissue lipid metabolism in farmed European (Dicentrarchus labrax) and Asian seabass (Lates calcarifer)". Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology 231 (2019): 170-176. http://dx.doi.org/10.1016/j.cbpa.2019.02.025. 10.1016/j.cbpa.2019.02.025 Rito, João; Viegas, Ivan; Pardal, Miguel Â.; Metón, Isidoro; Baanante, Isabel V.; Jones, John G.. "Utilization of glycerol for endogenous glucose and glycogen synthesis in seabass (Dicentrarchus labrax): A potential mechanism for sparing amino acid catabolism in carnivorous fish". Aquaculture 498 (2019): 488-495. http://dx.doi.org/10.1016/j.aquaculture.2018.08.066. 10.1016/j.aquaculture.2018.08.066 Jarak, Ivana; Barosa, Cristina; Martins, Fatima O.; Silva, Joao C. P.; Santos, Cristiano; Belew, Getachew Debas; Rito, Joao; et al. "Sources of hepatic glycogen synthesis in mice fed with glucose or fructose as the sole dietary carbohydrate". Magnetic Resonance in Medicine 81 1 (2018): 639-644. http://dx.doi.org/10.1002/mrm.27378. 10.1002/mrm.27378 Silva, João C. P.; Mota, Marta; Martins, Fátima O.; Nogueira, Célia; Gonçalves, Teresa; Carneiro, Tatiana; Pinto, Joana; et al. "Intestinal Microbial and Metabolic Profiling of Mice Fed with High-Glucose and High-Fructose Diets". Journal of Proteome Research 17 8 (2018): 2880-2891. http://dx.doi.org/10.1021/acs.jproteome.8b00354. 10.1021/acs.jproteome.8b00354 Rito, Joao; Viegas, Ivan; Pardal, Miguel A.; Meton, Isidoro; Baanante, Isabel V.; Jones, John G.. "Disposition of a Glucose Load into Hepatic Glycogen by Direct and Indirect Pathways in Juvenile Seabass and Seabream". Scientific Reports 8 (2018): http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000419941000005&KeyUID=WOS:000419941000005. 10.1038/s41598-017-19087-y Huang, Hu; Lee, Seung-Hwan; Sousa-Lima, Ines; Kim, Sang Soo; Hwang, Won Min; Dagon, Yossi; Yang, Won-Mo; et al. "Rho-kinase/AMPK axis regulates hepatic lipogenesis during overnutrition". Journal of Clinical Investigation 128 12 (2018): 5335-5350. https://publons.com/wos-op/publon/19310035/. 10.1172/JCI63562 Viegas, Ivan; Araujo, Pedro M.; Rocha, Afonso D.; Villegas, Auxiliadora; Jones, John G.; Ramos, Jaime A.; Masero, Jose A.; Alves, Jose A.. "Metabolic plasticity for subcutaneous fat accumulation in a longdistance migratory bird traced by (H2O)-H-2". Journal of Experimental Biology 220 6 (2017): 1072-1078. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000397614200019&KeyUID=WOS:000397614200019. 10.1242/jeb.150490 Flachs, P.; Adamcova, K.; Zouhar, P.; Marques, C.; Janovska, P.; Viegas, I.; Jones, Jg; et al. "Induction of lipogenesis in white fat during cold exposure in mice: link to lean phenotype". International Journal of Obesity 41 3 (2017): 372-380. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000395816000003&KeyUID=WOS:000395816000003. 10.1038/ijo.2016.228 Hernandez, Elisa Alvarez; Kahl, Sabine; Seelig, Anett; Begovatz, Paul; Irmler, Martin; Kupriyanova, Yuliya; Nowotny, Bettina; et al. "Acute dietary fat intake initiates alterations in energy metabolism and insulin resistance". Journal of Clinical Investigation 127 2 (2017): 695-708. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000394164100029&KeyUID=WOS:000394164100029. 10.1172/JCI89444 Jones, John G; Silva, Joao C P. "Improving Metabolic Control Through Functional Foods.". Current medicinal chemistry (2017): http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=MEDLINE&KeyUT=MEDLINE:28545368&KeyUID=MEDLINE:28545368. 10.2174/0929867324666170523130123 Rito, Joao; Viegas, Ivan; Pardal, Miguel A.; Jones, John G.. "Evidence of extensive plasma glucose recycling following a glucose load in seabass". Comparative Biochemistry and Physiology a-Molecular & Integrative Physiology 211 (2017): 41-48. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000406565900006&KeyUID=WOS:000406565900006. 10.1016/j.cbpa.2017.05.009 Varghese, Ron T.; Man, Chiara Dalla; Sharma, Anu; Viegas, Ivan; Barosa, Cristina; Marques, Catia; Shah, Meera; et al. "Mechanisms Underlying the Pathogenesis of Isolated Impaired Glucose Tolerance in Humans". Journal of Clinical Endocrinology & Metabolism 101 12 (2016): 4816-4824. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000390951000035&KeyUID=WOS:000390951000035. 10.1210/jc.2016-1998 Gonzalez, Juan D.; Silva-Marrero, Jonas I.; Meton, Isidoro; Caballero-Solares, Albert; Viegas, Ivan; Fernandez, Felipe; Minarro, Montserrat; et al. "Chitosan-Mediated shRNA Knockdown of Cytosolic Alanine Aminotransferase Improves Hepatic Carbohydrate Metabolism". Marine Biotechnology 18 1 (2016): 85-97. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000378136600007&KeyUID=WOS:000378136600007. 10.1007/s10126-015-9670-8 Marques, Catia; Viegas, Filipa; Rito, Joao; Jones, John; Viegas, Ivan. "Determination of muscle protein synthesis rates in fish using (H2O)-H-2 and H-2 NMR analysis of alanine". Analytical Biochemistry 509 (2016): 111-114. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000380866800018&KeyUID=WOS:000380866800018. 10.1016/j.ab.2016.07.011 Coelho, Margarida; Valente-Silva, Paula; Tylki-Szymanska, Anna; Henriques, Tiago; Barosa, Cristina; Carvalho, Filipa; Jones, John G.; Jones, John G. "Demonstration of Glucose-6-Phosphate Hydrogen 5 Enrichment from Deuterated Water by TransaldolaseMediated Exchange Alone". Magnetic Resonance in Medicine 75 4 (2016): 1781-1786. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=CCC&KeyUT=CCC:000372910900040&KeyUID=CCC:000372910900040. 10.1002/mrm.25749 Jones, John G.; Jones, John G. "Hepatic glucose and lipid metabolism". Diabetologia 59 6 (2016): 1098-1103. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=CCC&KeyUT=CCC:000378048500004&KeyUID=CCC:000378048500004. 10.1007/s00125-016-3940-5 Varghese, Ron T.; Viegas, Ivan; Barosa, Cristina; Marques, Catia; Shah, Meera; Rizza, Robert A.; Jones, John G.; Venal, Adrian. "Diabetes-Associated Variation in TCF7L2 Is Not Associated With Hepatic or Extrahepatic Insulin Resistance". Diabetes 65 4 (2016): 887-892. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=CCC&KeyUT=CCC:000372859200008&KeyUID=CCC:000372859200008. 10.2337/DB15-1593 Coelho, Margarida; Mendes, Vera M.; Lima, Ines S.; Martins, Fatima O.; Fernandes, Ana B.; Paula Macedo, M.; Jones, John G.; Manadas, Bruno. "Direct analysis of [6,6-H-2(2)]glucose and [U-C-13(6)]glucose dry blood spot enrichments by LC-MS/MS". Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences 1022 (2016): 242-248. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000376545800032&KeyUID=WOS:000376545800032. 10.1016/j.jchromb.2016.04.027 Viegas, Ivan; Jarak, Ivana; Rito, Joao; Carvalho, Rui A; Meton, Isidoro; Pardal, Miguel A; Baanante, Isabel V; Jones, John G. "Effects of dietary carbohydrate on hepatic de novo lipogenesis in European seabass (Dicentrarchus labrax L.).". Journal of lipid research 57 7 (2016): 1264-72. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=MEDLINE&KeyUT=MEDLINE:27247346&KeyUID=MEDLINE:27247346. 10.1194/jlr.M067850 Martins, Fatima O.; Delgado, Teresa C.; Viegas, Joana; Gaspar, Joana M.; Scott, Donald K.; O'Doherty, Robert M.; Macedo, M. Paula; Jones, John G.. "Mechanisms by which the thiazolidinedione troglitazone protects against sucrose-induced hepatic fat accumulation and hyperinsulinaemia". British Journal of Pharmacology 173 2 (2016): 267-278. https://publons.com/wos-op/publon/2029575/. 10.1111/BPH.13362 Jones, J.; Kahl, S.; Carvalho, F.; Barosa, C.; Roden, M.. "Simplified analysis of acetaminophen glucuronide for quantifying gluconeogenesis and glycogenolysis using deuterated water". Analytical Biochemistry 479 (2015): 37-39. http://dx.doi.org/10.1016/j.ab.2015.03.018. 10.1016/j.ab.2015.03.018 Jones, J. G.. "Noninvasive stable-isotope tracer methods for the study of hepatic intermediary metabolism". European Journal of Clinical Investigation 45 (2015): 26-26. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000354124800073&KeyUID=WOS:000354124800073. Burgess, Shawn C.; Merritt, Mathew E.; Jones, John G.; Browning, Jeffrey D.; Sherry, A. Dean; Malloy, Craig R.. "Limitations of detection of anaplerosis and pyruvate cycling from metabolism of [1-C-13] acetate". Nature Medicine 21 2 (2015): 20-21. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=CCC&KeyUT=CCC:000348974800007&KeyUID=CCC:000348974800007. 10.1038/NM.3789 Valente-Silva, Paula; Lemos, Cristina; Koefalvi, Attila; Cunha, Rodrigo A.; Jones, John G.. "Ketone bodies effectively compete with glucose for neuronal acetyl-CoA generation in rat hippocampal slices". Nmr in Biomedicine 28 9 (2015): 1111-1116. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000359809800006&KeyUID=WOS:000359809800006. 10.1002/nbm.3355 Viegas, Ivan; Rito, Joao; Jarak, Ivana; Leston, Sara; Caballero-Solares, Albert; Meton, Isidoro; Pardal, Miguel A.; Baanante, Isabel V.; Jones, John G.. "Contribution of dietary starch to hepatic and systemic carbohydrate fluxes in European seabass (Dicentrarchus labrax L.)". British Journal of Nutrition 113 9 (2015): 1345-1354. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000355283800002&KeyUID=WOS:000355283800002. 10.1017/S0007114515000574 Coelho, Margarida; Nunes, Patricia; Mendes, Vera M.; Manadas, Bruno; Heerschap, Arend; Jones, John G.. "Effect of Global ATGL Knockout on Murine Fasting Glucose Kinetics". Journal of Diabetes Research (2015): http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000358227400001&KeyUID=WOS:000358227400001. 10.1155/2015/542029 Schneeberger, Marc; Gomez-Valades, Alicia G.; Altirriba, Jordi; Sebastian, David; Ramirez, Sara; Garcia, Ainhoa; Esteban, Yaiza; et al. "Reduced alpha-MSH Underlies Hypothalamic ER-Stress-Induced Hepatic Gluconeogenesis". Cell Reports 12 3 (2015): 361-370. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000358324900002&KeyUID=WOS:000358324900002. 10.1016/j.celrep.2015.06.041 Duarte, Joao A. G.; Carvalho, Filipa; Pearson, Mackenzie; Horton, Jay D.; Browning, Jeffrey D.; Jones, John G.; Burgess, Shawn C.. "A high-fat diet suppresses de novo lipogenesis and desaturation but not elongation and triglyceride synthesis in mice". Journal of Lipid Research 55 12 (2014): 2541-2553. 10.1194/jlr.M052308 Nunes, Patricia M.; Wright, Alan J.; Veltien, Andor; van Asten, Jack J. A.; Tack, Cees J.; Jones, John G.; Heerschap, Arend. "Dietary lipids do not contribute to the higher hepatic triglyceride levels of fructose- compared to glucose-fed mice". Faseb Journal 28 5 (2014): 1988-1997. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=CCC&KeyUT=CCC:000335336000004&KeyUID=CCC:000335336000004. 10.1096/FJ.13-241208 Viegas, Ivan; Caballero-Solares, Albert; Rito, Joao; Giralt, Marina; Pardal, Miguel A.; Meton, Isidoro; Jones, John G.; Baanante, Isabel V.. "Expressional regulation of key hepatic enzymes of intermediary metabolism in European seabass (Dicentrarchus labrax) during food deprivation and refeeding". Comparative Biochemistry and Physiology a-Molecular & Integrative Physiology 174 (2014): 38-44. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000337851700006&KeyUID=WOS:000337851700006. 10.1016/j.cbpa.2014.04.004 Nunes, Patricia M.; Jarak, Ivana; Heerschap, Arend; Jones, John G.. "Resolving Futile Glucose Cycling and Glycogenolytic Contributions to Plasma Glucose Levels Following a Glucose Load". Magnetic Resonance in Medicine 71 4 (2014): 1368-1373. 10.1002/mrm.24789 John G. Jones. "Identifying Sources of Hepatic Lipogenic Acetyl-CoA Using Stable Isotope Tracers and NMR". Advances in Radiology (2014): https://publons.com/wos-op/publon/49841854/. 10.1155/2014/109252 Carvalho, F.; Duarte, J.; Simoes, A.R.; Cruz, P.F.; Jones, J.G.. "Noninvasive measurement of murine hepatic acetyl-CoA C 13 -enrichment following overnight feeding with C 13 -enriched fructose and glucose". BioMed Research International 2013 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84880126867&partnerID=MN8TOARS. 10.1155/2013/638085 Basu, Rita; Barosa, Cristina; Jones, John; Dube, Simmi; Carter, Rickey; Basu, Ananda; Rizza, Robert A.. "Pathogenesis of Prediabetes: Role of the Liver in Isolated Fasting Hyperglycemia and Combined Fasting and Postprandial Hyperglycemia". Journal of Clinical Endocrinology & Metabolism 98 3 (2013): E409-E417. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=CCC&KeyUT=CCC:000316417200001&KeyUID=CCC:000316417200001. 10.1210/JC.2012-3056 Barosa, Cristina; Jones, John G.; Rizza, Robert; Basu, Ananda; Basu, Rita; Barosa, C.; Jones, J.G.; et al. "Acetaminophen glucuronide and plasma glucose report identical estimates of gluconeogenesis and glycogenolysis for healthy and prediabetic subjects using the deuterated water method". Magnetic Resonance in Medicine 70 2 (2013): 315-319. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=CCC&KeyUT=CCC:000322128300003&KeyUID=CCC:000322128300003. 10.1002/mrm.24485 Viegas, I.; Rito, J.; González, J.D.; Jarak, I.; Carvalho, R.A.; Metón, I.; Pardal, M.A.; Baanante, I.V.; Jones, J.G.. 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American Journal of Physiology-Endocrinology and Metabolism 305 4 (2013): E465-E474. 10.1152/ajpendo.00245.2013 Delgado, T.C.; Martins, F.O.; Carvalho, F.; Gonçalves, A.; Scott, D.K.; O'Doherty, R.; Paula Macedo, M.; Jones, J.G.. "2H enrichment distribution of hepatic glycogen from 2H2O reveals the contribution of dietary fructose to glycogen synthesis". American Journal of Physiology - Endocrinology and Metabolism 304 4 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84874073240&partnerID=MN8TOARS. 10.1152/ajpendo.00185.2012 Barosa, Cristina; Silva, Claudia; Fagulha, Ana; Barros, Luísa; Caldeira, M. Madalena; Carvalheiro, Manuela; Jones, John G.; et al. "Sources of hepatic glycogen synthesis following a milk-containing breakfast meal in healthy subjects". 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Analytical Biochemistry 217 1 (1994): 148-152. http://dx.doi.org/10.1006/abio.1994.1095. 10.1006/abio.1994.1095 BURTON, KP; JONES, JG; LE, TH; SHERRY, AD; MALLOY, CR. "EFFECTS OF OXIDANT EXPOSURE ON SUBSTRATE UTILIZATION AND HIGH-ENERGY PHOSPHATES IN ISOLATED RAT HEARTS". Circulation Research 75 1 (1994): 97-104. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:A1994NV03100012&KeyUID=WOS:A1994NV03100012. 10.1161/01.RES.75.1.97 Sherry, A.D.; Sumegi, B.; Miller, B.; Cottam, G.L.; Gavva, S.; Jones, J.G.; Malloy, C.R.; et al. "Orientation-conserved transfer of symmetric krebs cycle intermediates in mammalian tissue". Biochemistry 33 20 (1994): 6268-6275. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028356902&partnerID=MN8TOARS. 10.1021/bi00186a029 Jones, J.G.; Sherry, A.D.; Jeffrey, F.M.H.; Storey, C.J.; Malloy, C.R.; JONES, JG; SHERRY, AD; et al. "Sources of acetyl-CoA entering the tricarboxylic acid cycle as determined by analysis of succinate 13C isotopomers". Biochemistry 32 45 (1993): 12240-12244. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027359228&partnerID=MN8TOARS. 10.1021/bi00096a037 JONES, JG; BELLION, E. "METHYLAMINE METABOLISM IN HANSENULA-POLYMORPHA - AN INVIVO C-13 AND P-31 NUCLEAR-MAGNETIC-RESONANCE STUDY". JOURNAL OF BACTERIOLOGY 173 16 (1991): 4959-4969. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:A1991GB01400007&KeyUID=WOS:A1991GB01400007. 10.1128/JB.173.16.4959-4969.1991 JONES, JG; BELLION, E. "METHANOL OXIDATION AND ASSIMILATION IN HANSENULA-POLYMORPHA - AN ANALYSIS BY C-13 NMR INVIVO". BIOCHEMICAL JOURNAL 280 (1991): 475-481. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:A1991GU90100031&KeyUID=WOS:A1991GU90100031. 10.1042/BJ2800475 JONES, JG; BELLION, E. "INVIVO C-13 AND N-15 NMR-STUDIES OF METHYLAMINE METABOLISM IN PSEUDOMONAS SPECIES MA". JOURNAL OF BIOLOGICAL CHEMISTRY 266 18 (1991): 11705-11713. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:A1991FT76200046&KeyUID=WOS:A1991FT76200046.
Capítulo de livro	Viegas, Ivan; Albuquerque Carvalho, Rui de; ngelo, Miguel; Griffith, John. "Advances and Applications of Tracer Measurements of Carbohydrate Metabolism in Fish". In New Advances and Contributions to Fish Biology. InTech, 2012. 10.5772/54053 Barosa, C.; Jones, J. G.. "Recent Developments in the use of Stable Isotope Carbohydrate Tracers for the Study of Human Health". editado por Rauter, A. P.; Lindhorst, T. K., 208-226. 2011. 10.1039/9781849732765-00208 Jones, John. "Chapter 8: Recent developments in the use of stable isotope carbohydrate tracers for the study of human health in carbohydrate chemistry". 2011. Jones, John. "Chapter 6: Direct and indirect pathways of hepatic glycogen synthesis in normal and in insulin resistant states". In Advances in Medicine and Biology. 2010. Jones, John. "Chapter 8: Tracing hepatic glucose and glycogen fluxes with 2H2O". In Clinical Diabetes Research: Methods and Techniques. 2007.
Livro	Jones, John. Dietary Sugars. Royal Society of Chemistry. 2012. 10.1039/9781849734929 Jones, John. Carbohydrate Chemistry. Royal Society of Chemistry. 2011. 10.1039/9781849732765 Jones, J.G.. Tracing Hepatic Glucose and Glycogen Fluxes with 2H2O. 2007. 10.1002/9780470513095.ch8
Poster em conferência	Palma, Mariana; Tavares, L C; Coelho, Margarida; Jones, John; Viegas, Ivan. Autor correspondente: Palma, Mariana. "NMR-Metabolomics in Aquaculture - case studies from farmed fish species". Trabalho apresentado em ENAQUA - National Aquaculture Meeting\|CIMAR-LA, 2025. Tavares, L C; Lente-Silva, Afonso; Palma, Mariana; Coelho, Margarida; Viegas, Ivan; Jones, John. Autor correspondente: Tavares, L C. "Sources of hepatic glycogen traced by 13C-NMR in frugivorous amazon tambaqui Colossoma macropomum". Trabalho apresentado em Aquaculture Europe 2025, 2025. Silva, João Gabriel; Tavares, L C; Belew, Getachew Debas; Gil, Ana; Jones, John. "Exploring the lipidomic profiles of mice extrahepatic tissues in high-fat-induced NAFLD using 1H-NMR". Trabalho apresentado em IV Metabolism Ageing and Disease Meeting, 2024. Reis-Costa, Ana; Maria João Pereira; Jan Eriksson; Jones, John. "Metabolic Remodelling in Adipose Tissue: Insights from Rouxen- Y Gastric Bypass Surgery on Fructose Production". Trabalho apresentado em IV Metabolism, Ageism & Disease (MAD) Meeting - Disease and Therapeutics: from the Past to Future, 2024. Silva, João Gabriel; Ludgero, L C; Belew, Getachew Debas; Carvalho, RA; Carvalho, R; Carvalho Rui; Gil, Ana; Jones, John. Autor correspondente: Silva, João Gabriel. "Tecidos extra-hepáticos e dFGNA induzida pela dieta: uma nova perspetiva através de metabolómica". Trabalho apresentado em 19º Congresso Português de Diabetes, 2023. Reis-Costa, Ana; Belew, Getachew Debas; Barosa, C.; Ivan Viegas; Ludgero Tavares; Jones, John. "O impacto de diferentes dietas lipogénicas na síntese de glicogénio no contexto da doença de Fígado Gordo Não Alcoólico". Trabalho apresentado em 19º Congresso Português de Diabetes, 2023. Silva, João Gabriel; Ludgero, L C; Carvalho, RA; Carvalho, R; Carvalho Rui; Gil, Ana; Jones, John. Autor correspondente: Silva, João Gabriel. "Extrahepatic Tissue And Diet-induced NAFLD: A New Insight Through Metabolomics". Trabalho apresentado em BEBDay 2023, 2023. Pinhanços, SS or Pinhanços, SM; Fernandes, Hugo; Jones, John. Autor correspondente: Fernandes, Hugo. "High-throughput screening identifies microRNAs capable of rescuing beta cells from glucolipotoxicity-induced cell death". Trabalho apresentado em EASO-ECN Winter School, 2022. Silva, João Gabriel; Tavares, L C; Gil, Ana M.; Jones, John. Autor correspondente: Silva, João Gabriel. "Non-Alcoholic Fatty Liver Disease and Western Diet: A Tale of the Effects in the Metabolomics of the Heart". Trabalho apresentado em VI meet.Lab 2022, 2022. Patarrão, Rita S.; INÊS SOUSA-LIMA; Meneses, MJ; RIBEIRO, ROGÉRIO; Rita Andrade; JOAO FILIPE RAPOSO; Jones, John; Macedo, MP. "Daily coffee intake has a protective effect on intestinal permeability and hepatic steatosis/fibrosis in type 2 diabetes". Trabalho apresentado em International Diabetes Federation (IDF) World Diabetes Congress 2022, 2022. Reis-Costa, Ana; Belew, Getachew Debas; Cristina Barosa; Ivan Viegas; Ludgero Tavares; Jones, John. "The Impact of High-Fat Feeding on Direct and Indirect Pathway Contributions to Hepatic Glycogen Synthesis in a Mouse Model of Non-Alcoholic Fatty Liver Disease". Trabalho apresentado em 54th Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI) \| COVID-19 Edition, 2020. Torres, Alejandra; Belew, Getachew ; Di Nunzio, Giada; Tavares, Ludgero; Jones, John. Autor correspondente: Jones, John. "Quantifying the contributions of the fructose and glucose components of high-fructose corn syrup formulation (HFCS-55) to hepatic glycogen synthesis". Trabalho apresentado em 56th Anual Meeting for the European Association for the Study of Diabetes, 2020. Coelho, Margarida; Barosa, C.; Jones, John. "Evaluation of carbohydrate biosynthesis with 18O-enriched water and isotope shifted 13C NMR analysis: Proof of concept". Trabalho apresentado em 56th Annual Meeting of European Association for the Study of Diabetes, 2020. Coelho, Margarida; Barosa, C.; Jones, John. "Avaliação do metabolismo de fosfatos de açúcar usando água enriquecida com 18O e análise por 13C RMN com deslocamento isotópico: prova de conceito". Trabalho apresentado em 16º Congresso Português de Diabetes, 2020. Costa, Ana; Giada di Nunzio; Belew, Getachew Debas; Torres, Alejandra; Ludgero Tavares; Jones, John. "Alterações na lipogénese de novo hepática em murganhos submetidos ao xarope HFCS-55 rico em frutose". Trabalho apresentado em 16º Congresso Português de Diabetes, 2020. SOUSA-LIMA, INÊS; Patarrão, RS; Meneses, MJ; Pina, AF; Coelho, Margarida; Raposo, JF; Ribeiro, Rogério José Tavares; et al. "Serum levels of the Zonulin family of peptides in individuals from the PREVADIAB 2 cohort, a role in metabolic dysfunction". Trabalho apresentado em 56th Annual Meeting of the European Association for the Study of Diabetes,, 2020. SOUSA-LIMA, INÊS; Patarrão, Rita; Meneses, Maria João; Pina, AF; Coelho, M; Raposo, JF; Ribeiro, RT; et al. "Níveis séricos de péptidos da família da zonulina em indivíduos do PREVADIAB2". Trabalho apresentado em 16º Congresso Português de Diabetes, 2020. Di Nunzio, Giada; Santamaria, Raphael; Fonseca, Ana Catarina; Petkovic, Marija; Santos, Diana; Piscosquito, Arianna; Carvalho, Eugenia; Jones, John. "Impact of second generation antipsychotics on insulin sensitivity and mitochondrial bioenergetics after acute treatment in rats.". Trabalho apresentado em 55th Annual Meeting of the European Association for the Study of Diabetes, 2019. Barbosa, André Filipe; Amorim, Ricardo; Tavares, L C; Jones, John; Veloso, Caroline; Benfeito, Ester; Borges, Fernanda; Paulo Jorge Gouveia Simoes Da Silva Oliveira; Teixeira, José. "Redox signaling and metabolism modulation of human fibroblasts by mitochondria-targeted polyphenolic constructs". Trabalho apresentado em 53 rd Annual Meeting of the European Society for Clinical Investigation, 2019. Di Nunzio, Giada; Santamaria, Raphael; Fonseca, Ana Catarina; Petkovic, Marija; Santos, Diana; Piscoquito, Arianna; Carvalho, Eugenia; Jones, John. "Impact of second-generational antipsychotics on mitochondrial bioenergetics after acute treatment in rats.". Trabalho apresentado em 53rd Annual Scientific Meeting of the European Society for Clinical Investigation, 2019. Nunzio, Giada Di; Santamaria, Raphael; Ana Catarina RG Fonseca; Petkovic, Marija; Santos, Diana; Piscosquito, Arianna; Carvalho, Eugenia; Jones, John. "Impact of second-generation antipsychotics on mitochondrial bioenergetics after acute treatment in rats". Trabalho apresentado em 53rd Annual Scientific Meeting of the European Society for Clinical Investigation, 2019. Jones, John; Silva, João; Viegas, Ivan; Marques, C; Martins, FO; Macedo, Maria Paula. "A frutose contribui de forma superior para a síntese hepática de ácidos gordos saturados comparativamente a oleato". Trabalho apresentado em 15º Congresso Português de Diabetes, 2019. Coelho, Margarida; Vera M. Mendes; Rogério Ribeiro; RAPOSO, JOAO; Jones, John; Bruno Manadas. "Determinação da produção de glucose endógena por LC-MS/MS em humanos com recurso a tracers de glucose". Trabalho apresentado em Annual Meeting of the Portuguese Society of Diabetology, 2018. Coelho, Margarida; Cátia Marques; Ludgero Tavares; Ivan Viegas; Jones, John. "The importance of being optimized: CPMG in HR-MAS NMR metabolomics". Trabalho apresentado em VIII Ibero-American NMR meeting, 2018. Coelho, Margarida; Vera M. Mendes; Inês S. Lima; Fátima O. Martins; Paula M. Macedo; Jones, John; Bruno Manadas. "Análise cinética de fluxos de glucose através dos enriquecimentos em [6,6-2H2]glucose e [U-13C6]glucose em dried blood spots por LC-MS/MS". Trabalho apresentado em Annual Meeting of the Portuguese Society of Diabetology, 2016. Jarak, Ivana; Oliveira, Helena; Ferreira de Oliveira, José Miguel P.; Gil, Ana M.; Jones, John; Duarte, I.F.. "NMR study of altered flux through pentose phosphate pathway in human cells exposed to silver nanoparticles.". Trabalho apresentado em Research Day 2014, 2014. Coelho, Margarida; Paula Valente-Silva; Cristina Barosa; Filipa Carvalho; Jones, John. "Enrichment of glucose-6-phosphate from 2H2O in erythrocyte hemolysates by transaldolase exchange activity". Trabalho apresentado em XVIII Congress of the Portuguese Biochemical Society, 2014. Martins, FO; Tovar, S; Perez-Sieira, S; González-Touceda, D; Jones, John; Natali, A; Diéguez, C; Macedo, Maria Paula. "Hypothalamic nitric oxide regulates peripheral insulin bioavailability". Trabalho apresentado em 49th Annual Meeting of the European Association for the Study of Diabetes (EASD), 2013. Martins, FO; Jones, John; Ribeiro, RT; Mari, A; Natali, A; Macedo, Maria Paula. "Impact of nitric oxide synthase (NOS) activity on insulin clearance". Trabalho apresentado em FEPS Spain, 2012. Martins, FO; Jones, John; Ribeiro, RT; Mari, A; Natali, A; Macedo, Maria Paula. "Insulin clearance regulation: a role for nitric oxide". Trabalho apresentado em 48th Annual Meeting of the European Association for the Study of Diabetes (EASD), 2012. Lima, IS; Fernandes, AB; Mari, A; Manadas, B; Mendes, V; Jones, John; Macedo, Maria Paula. "The role of the Hepatic Parasympathetic System and Nitric Oxide Synthase (NOS) in Peripheral Insulin Action". Trabalho apresentado em FEPS Spain, 2012. Mendes, V; Jones, John; Macedo, Maria Paula; Fernandes, AB; Manadas, B. "Analysis of glucose enrichment from a double tracer meal tolerance test by LC-MS". Trabalho apresentado em 47th Annual Meeting of the European Association for the Study of Diabetes (EASD), 2011. Ana M Silva; Martins, Fátima Patrícia da Costa Oliveira; Jones, John; Carvalho, RA; Carvalho, R; Carvalho Rui. "Looking for the Roots of Liver de novo lipogenesis: 2H NMR analysis of hepatic glutamate and triglycerides". Trabalho apresentado em Survival or Death as a Matter of Fat, International Courses on Toxicology, CNC-UC, 2010.
Resumo em conferência	Silva, João Gabriel; Barosa, C.; Dulce Nascimento Ó; RAPOSO, JOAO; Andrade, Ana; Ribeiro RT; Tavares, L C; Gil, Ana M.; Jones, John. Autor correspondente: Jones, John. "Non-invasive assessment of meal [U-13C]glucose conversion to hepatic cytosolic acetyl-CoA in T2D/MASLD patients using p-amino benzoic acid". Trabalho apresentado em EGIR-MASLD Study Group Meeting 2025, Pisa, 2025. Publicado Silva, João Gabriel; Barosa, C.; Dulce do Ó; RAPOSO, JOAO; Andrade, Rita; Ribeiro, Rogério José Tavares; Gil, Ana M.; Tavares, L C; Jones, John. Autor correspondente: Jones, John. "Coupling p-aminobenzoic acid (PABA) with stable isotope tracers to non-invasively capture human hepatic metabolic fluxes". Trabalho apresentado em 59th Annual Scientific Meeting of the European Society for Clinical Investigation, Genoa, 2025. Publicado Silva, João Gabriel; Barosa, Cristina; Dulce do Ó; RAPOSO, JOAO; Rita Andrade; Ribeiro, Rogério José Tavares; Jones, John. Autor correspondente: Silva, João Gabriel. "Uso de Ácido p-aminobenzóico como biópsia química não-invasiva para capturar fluxos metabólicos hepáticos em humanos". Trabalho apresentado em 20º Congresso Português de Diabetes, Vilamoura, 2025. Publicado Silva, João Gabriel; Tavares, Ludgero; Belew, Getachew Debas; Gil, Ana; Jones, John. "High-fat induced MASLD beyond the liver: metabolic profiling of mice extrahepatic tissues as analysed by 1H-NMR". Trabalho apresentado em 60th Annual Meeting of the European Association for the Study of Diabetes, Madrid, 2024. Publicado Silva, João Gabriel; Ludgero C. Tavares; Belew, Getachew Debas; Gil, Ana; Jones, John. Autor correspondente: Jones, John. "Beyond the liver: Impact of high-fat-induced MASLD in the lipidomic profiles of mice extrahepatic tissues". Trabalho apresentado em 58th Annual Scientific Meeting of the European Society for Clinical Investigation, Barcelona, 2024. Aceite para publicação • https://doi.org/10.1111/eci.14220 Magalhães, Carina; Amorim, Ricardo; Benfeito, Sofia ; Fernando Caride; Ludgero Tavares; Sardão, Vilma; Jones, John; et al. "Repurposing the effects of decyl-TPP mitochondriotropic caffeic acid antioxidant AntiOxCIN6: The impact of rewiring mitochondrial metabolism on cisplatin anticancer therapy". Trabalho apresentado em 58th Annual Meeting of the European Society for Clinical Investigation, Barcelona, 2024. Silva, João Gabriel; Ludgero, L C; Belew, Getachew Debas; Gil, Ana; Jones, John. Autor correspondente: Jones, John. "Indo além do Fígado: Impacto de dFGNA induzida por dieta no perfil lipídico de tecidos extra-hepáticos de murganhos". Trabalho apresentado em 20º Congresso Português de Diabetes, Loulé, 2024. Publicado Reis-Costa, Ana; Maria João Pereira; Jan Eriksson; Jones, John. "Modulação metabólica: Influência da cirurgia de bypass gástrico em Y de Roux no metabolismo de frutose". Trabalho apresentado em 20º Congresso Português de Diabetes, 2024. Aceite para publicação Carina C. Magalhães; Amorim, Ricardo; Benfeito, Sofia ; Fernando Caride; Ludgero Tavares; Jones, John; Borges, Fernanda; Oliveira, Paulo J.; Teixeira, José. "AntiOxCIN6 potentiates cisplatin anticancer therapy by lowering mitochondrial metabolism while upregulating energetic glycolytic dependence". Trabalho apresentado em MAC 2023, Mitochondria in Aging, Cancer and Cell Death, 2023, 2023. Amorim, Ricardo; Magalhães, Carina; Benfeito, Sofia; Cagide, Fernando; Ludgero Tavares; Jones, John; Fernanda Borges; Oliveira, Paulo J.; Teixeira, José. "Anticancer properties of AntiOxCIN6: repurposing the effects of a cytotoxic mitochondria-targeted caffeic acid antioxidant". Trabalho apresentado em International Meeting MitoPorto 2023, Coimbra, 2023. Amorim, Ricardo; Carina C. Magalhães; Benfeito, Sofia ; Ludgero Tavares; Jones, John; Borges, Fernanda; Oliveira, Paulo J.; Teixeira, José. "The mitochondriotropic antioxidant based on caffeic acid AntiOxCIN6 induces a shift in metabolic profile towards a more glycolytic phenotype: implications for lung cancer therapy". Trabalho apresentado em BEB day, 2023. Amorim, Ricardo; Magalhães, Carina; Benfeito, Sofia ; Ludgero Tavares; Baldeiras, Ines; Jones, John; Fernanda Borges; Paulo J. Oliveira; Teixeira, José. "The mitochondriotropic antioxidant based on caffeic acid AntiOxCIN6 lowers mitochondrial metabolism while upregulating glycolysis in human HepG2 cells". Trabalho apresentado em 53rd Meeting of the Portuguese Society of Pharmacology, 2023. Silva, João Gabriel; Tavares, L C; Belew, Getachew Debas; Carvalho, R A; Gil, Ana; Jones, John. Autor correspondente: Jones, John. "Tecidos extra-hepáticos e dFGNA induzida pela dieta: uma nova perspectiva metabolómica". Trabalho apresentado em 19th Portuguese Diabetes Congress, Vilamoura, 2023. Publicado Reis-Costa, Ana; Belew, Getachew Debas; Ludgero Tavares; Meneses, Maria João; Jones, John. "The impact of different lipogenic diets on indirect pathway contributions to hepatic glycogen synthesis". Trabalho apresentado em 57th European Association for the Study of Diabetes (EASD) Annual Meeting 2021, 2021. Jones, John; Silva, J.; Martins, F.O.; Viegas, I; Marques, C; Macedo, Maria Paula. "Fructose contributes more than glucose to hepatic de novo synthesis of saturated fatty acids and oleate". Trabalho apresentado em 55th EASD Annual Meeting of the European Association for the Study of Diabetes, 2019. Publicado Jones, John; Silva, J; Martins, FO; Viegas, I; Marques, C; Macedo, MP. "Fructose contributes more to the synthesis of saturated fatty acids than it does to oleate in the liver". Trabalho apresentado em 53rd Annual Scientific Meeting of the European Society for Clinical Investigation, 2019. Publicado • https://doi.org/10.1111/eci.13127 Jones, John; Silva, João; Martins, FO; Viegas, Ivan; Marques, C; Macedo, Maria Paula. "Fructose contributions to hepatic triglyceride synthesis in the presence of glucose during overnight feeding in mice". Trabalho apresentado em 54th EASD Annual Meeting of the European Association for the Study of Diabetes, 2018. Publicado Silva, J; Martins, FO; Marques, C; Macedo, Maria; Viegas, I; Jones, John. "Differential fractional synthetic and elongation rates of hepatic saturated fatty acids and oleate from dietary [U-13C] glucose in healthy mice". Trabalho apresentado em European Association for the Study of Diabetes (EASD) 2017 Annual Meeting, 2017. Publicado Jones, John; Silva, J; Marques, C; Viegas, I; Martins, FO; Macedo, Maria. "Differential contribution of glucose to triglyceride lipogenesis in visceral adipose tissue and liver following glucose/fructose supplementation". Trabalho apresentado em European Association for the Study of Diabetes (EASD) 2017 Annual Meeting, 2017. Publicado Martins, FO; Tovar, S; Jones, John; Diéguez, C; Macedo, Maria. "Hypothalamic nitric oxide regulates insulin signalling and hepatic lipid metabolism". Trabalho apresentado em European Association for the Study of Diabetes (EASD) 50th Annual Meeting, 2014. Publicado Martins, FO; Jones, John; Ribeiro, RT; Macedo, Maria. "In vivo insulin clearance regulation: a role for nitric oxide". Trabalho apresentado em 48th EASD (European Association for the Study of Diabetes) Annual Meeting, 2012. Publicado Ana M Silva; Martins, Fátima Patrícia da Costa Oliveira; Jones, John; Carvalho, RA; Carvalho, R; Carvalho Rui. "2H NMR Analysis of Hepatic Glutamate and Triglycerides: a window to Liver de novo Lipogenesis assessment". Trabalho apresentado em 14th ECSBM 2011, Coimbra, 2011. Lima, IS; Fernandes, AB; Jones, John; Macedo, Maria. "Altered glucose excursions during a meal tolerance test in an impaired hepatic vagal model are mainly due to peripheral insulin resistance". Trabalho apresentado em 47th Annual Meeting of the European Association for the Study of Diabetes, 2011. Publicado

Propriedade Intelectual

Patente

Jones, John. 2011. "Methods of Distinguishing Between Glutamine Formed by Cataplerosis or Proteolysis". Estados Unidos.
Jones, John. 2007. "Measurements of gluconeogenesis and intermediary metabolism using stable isotopes".
Jones, John. 2001. "Methods for determining gluconeogenesis, anapleurosis and pyruvate recycling". Estados Unidos.

Outros

Outra produção

ApoJ/clusterin serum levels in patients with impaired glucose tolerance. 2018. Maria João Meneses; I. Sousa-Lima; Patarrao RS; R. T. Ribeiro; L. Gardete-Correia; R. Duarte; J. M. Boavida; et al. https://novaresearch.unl.pt/en/publications/cf4b9b4e-b9b7-4b19-aa29-5be2d761285d.

Atividades

Orientação

	Título / Tema Papel desempenhado	Curso (Tipo) Instituição / Organização
2022/10/01 - Atual	The role of exogenous and endogenous fructose turnover in adipose tissue dysfunction during the development of Type 2 Diabetes Orientador
2022/10/01 - Atual	Development of a zebrafish model for high-resolution analyses of lipogenic fluxes in non-alcoholic fatty liver disease Orientador
2012/10/01 - Atual	Glycerol as a novel feedstock supplement for the sparing of dietary protein catabolism in farmed marine fish” Department of Life Sciences Orientador
2017/10/01 - 2022/12/10	Multiomic approaches for thyroid cancer diagnosis Orientador
2017/10/01 - 2022/02/01	“Multiomic approaches for thyroid cancer diagnosis Orientador
2017/10/01 - 2022/01/20	Fructose metabolism and lipogenesis fluxes in mice models of diet-induced non-alcoholic fatty liver disease Orientador
2017/10/01 - 2022/01/14	Fructose metabolism and lipogenesis fluxes in mice models of diet-induced non-alcoholic fatty liver disease Orientador
2017/10/01 - 2021/11/24	Tracing hepatic glycogen and lipid metabolism with stable isotope tracers: insights from murine studies Orientador
2017/10 - 2021/11/06	Tracing hepatic glycogen metabolism with stable isotope tracers - insights from murine studies Orientador
2019/09/01 - 2021/02/01	The effects of high fat feeding on the metabolomics of heart, kidney and skeletal muscle in C57BL6J mice as analysed by 1H NMR Orientador
2014/10/01 - 2020/05/12	Sugar, intestine & metabolic syndrome - high fructose feeding and hepatic fatty liver disease inflammation: the role of intestinal microbiota Orientador
2014/10/01 - 2020/02/04	Sugar, intestine & metabolic syndrome - high fructose feeding and hepatic fatty liver disease inflammation: the role of intestinal microbiota Orientador
2018/09/01 - 2020/02/01	NMR analysis of urinary acetaminophen glucuronide enrichments from 2H and 13C metabolic tracers in mouse models Orientador
2018/09/01 - 2020/02/01	The impact of different lipogenic diets on direct and indirect pathway contributions to hepatic glycogen synthesis Orientador
2016/09/01 - 2018/02/01	13C NMR analysis of triglyceride fatty acid enrichment from 13C-enriched lipogenic substrates Orientador
2013/09/01 - 2015/02/01	Ketone bodies as brain substrates Orientador
2013/09/01 - 2015/02/01	Quantifying triglyceride futile cycling with deuterated water and 2H NMR analysis of glycerol 2H enrichment Orientador
2010/10/01 - 2014/12/02	Brain-liver Nitric oxide – A Major Player in Insulin Clearance and Actions
2012/09/01 - 2013/10/01	Quantifying the effects of high fructose feeding on the intestinal permeability of endotoxins Orientador
2008/10/01 - 2012/11/12	Sources of Blood Glucose and Liver Glycogen in the Seabass: Implications for Carbohydrate Metabolism in Fish
2007/10/01 - 2012/02/10	Noninvasive measurements of human hepatic metabolism using deuterated water Orientador
2007/10/01 - 2012/01/20	Noninvasive Measurements of Human Hepatic Metabolism Using Deuterated Water
2007/01/01 - 2011/06/15	Profiling the control of hepatic glucose and lipid metabolism for evaluating novel strategies of insulin delivery
2005/10 - 2009/03	Insulin Resistance & Diabetes: Insights from Magnetic Resonance Studies of Hepatic Glucose & Lipid Metabolism

Organização de evento

	Nome do evento Tipo de evento (Tipo de participação)	Instituição / Organização
2019/05/09 - 2019/05/10	EASD-EGIR meeting in Lisbon (2019/05/09 - 2019/05/10) Conferência (Coorganizador)
2019/05/08 - 2019/05/09	EASD-NAFLD meeting in Lisbon (2019/05/08 - 2019/05/09) Conferência (Coorganizador)

Participação em evento

	Descrição da atividade Tipo de evento	Nome do evento Instituição / Organização
2022/12/05 - 2022/12/06	International Diabetes Federation Biennial Meeting Invited lecture: “Role of high sugar and high fat feeding on lipid overflow”	Biennial Meeting
2022/09/22 - 2022/09/23	European Association for the Study of Diabetes (EASD) 58th Annual meeting. invited lecture ¿Exogenous fructose and glucose as precursors for hepatic de novo synthesis of lipotoxic fatty acids¿ Conferência	European Association for the Study of Diabetes (EASD) annual meeting
2019/12/06 - 2019/12/07	International Diabetes Federation Biennial Meeting invited lecture "“The role of the microbiome in perturbing the gut-brain axis during high sugar and fat feeding” Conferência	International Diabetes Federation Biennial Meeting
2017/12/08 - 2017/12/09	International Diabetes Federation Biennial Meeting invited lecture “Metabolic flux profiling of non-alcoholic fatty liver disease” Conferência	International Diabetes Federation Biennial Meeting
2017/05/16 - 2017/05/17	Departmental seminar, Francis Crick Institute, “Metabolic studies in different organisms using deuterated water tracer” Seminário	Departmental Seminar
2017/03/04 - 2017/03/05	Departmental seminar CEDOC, New University of Lisbon "“Metabolic studies in different organisms using deuterated water tracer” Seminário	Departmental Seminar
2015/09/16 - 2015/09/17	European Association for the Study of Diabetes (EASD) 51st meeting. Symposium: The Liver in Focus, “Hepatic glucose and lipid metabolism” Conferência	Symposium: The Liver in Focus, “Hepatic glucose and lipid metabolism”
2014/10/20 - 2014/10/21	Departmental seminar, Institute of Physiology, Czech Republic “Studies of metabolism using deuterated water and 2H NMR” Seminário	Departmental Seminar
2012/09/02 - 2012/09/03	IV Ibero-American NMR Meeting invited lecture “Studies of metabolism with deuterated water and 2H NMR” Conferência	IV Ibero-American NMR Meeting
2011/11/12 - 2011/11/13	Departmental seminar, German Diabetes Center, “Novel approaches for assessing metabolic regulation in diabetes” Seminário	Departmental seminar, German Diabetes Center
2011/09/13 - 2011/09/14	Glycosciences in the International Year of Chemistry invited lecture “Effects and implications of transaldolase activity on glucose flux measurements in humans” Conferência	Glycosciences in the International Year of Chemistry
2008/09/12 - 2008/09/13	5th Iberian Spectroscopy Meeting invited lecture “Non-invasive studies of liver metabolism in humans by stable isotope tracers and NMR” Conferência	5th Iberian Spectroscopy Meeting
2008/09/06 - 2008/09/07	GLUPOR 8 meeting invited lecture “Liver carbohydrate metabolism in humans using stable isotope tracers and NMR.” Conferência	GLUPOR 8 meeting
2008/09/02 - 2008/09/03	4th Iberian Carbohydrate meeting invited lecture “Studies of carbohydrate metabolism in humans by stable isotope tracers and NMR” Conferência	4th Iberian Carbohydrate meeting
2007/09/05 - 2007/09/06	GLUPOR 7 meeting invited lecture “Studies of carbohydrate metabolism in humans by stable isotope tracers and NMR.” Conferência	GLUPOR 7 meeting
2003/12/05 - 2003/12/06	University of Algarve Biochemistry Department Departmental seminar “Non-invasive studies of glucose metabolism in humans” Seminário	Departmental Seminar

Arbitragem científica em conferência

	Nome da conferência	Local da conferência
2008/03/01 - Atual		Portuguese Association for Diabetology

Arbitragem científica em revista

	Nome da revista (ISSN)	Editora
2020/02/01 - Atual	Journal of Clinical Medicine

Comissão de avaliação

	Descrição da atividade Tipo de assessoria	Instituição / Organização	Entidade financiadora
2008/03/01 - Atual	Evaluator for Portuguese Association for Diabetology Projects and Prizes Avaliador
2022/05/01 - 2022/12/01	Evaluator for Portuguese Foundation of Science & Technology Ph.D. Fellowships Avaliador		Fundação para a Ciência e a Tecnologia

Membro de associação

	Nome da associação	Tipo de participação
2005/03/01 - Atual	Portuguese Society of Diabetology	Head of the Group for Fundamental and Translational Investigation (GIFT) from 2017-2023
2005/01/01 - Atual	European Association for the Study of Diabetes

Membro de comissão

	Descrição da atividade Tipo de participação	Instituição / Organização
2017/03/01 - 2023/03/15	Coordinator of the Group for Fundamental and Translational Investiagtion (GIFT) Study group for the Portuguese Society for Diabetology from 2017-2023 Coordenador
2017/05/06 - 2021/05/15	Board member for the European Association for the Study of Diabetes Insulin Resistance Study group Membro

Outro júri / avaliação

	Descrição da atividade	Instituição / Organização
2012/04/01 - Atual	Evaluator for the Romanian Executive Agency for Higher Education, Research, Development and Innovation Experimental Demonstrative Project Calls

Tutoria

	Tópico	Nome do aluno
2015/01/01 - Atual	Mentoring of FCT and DL57 Postdoctoral Fellowship and Contract	Cristina Barosa
2022/03/01 - 2022/07/01	Monteclimar fellowship for visiting students	Ivonne Palacios Marin
2021/10/01 - 2021/12/15	ERASMUS Student Exchange Fellowship	Charlotte Kahm
2018/01/01 - 2021/03/01	NMR studies of fructose metabolism in animal models	Ludgero Canário Tavares
2019/04/01 - 2019/06/30	Secondment of Student in the Marie Curie Training Network TREATMENT	Dora Koller
2019/03/01 - 2019/05/01	Secondment of Student in the Marie Curie Training Network FOIE GRAS	Sara Guerra
2013/01/01 - 2017/12/31	Developing stable isotope tracer studies in fish	Ivan Viegas
2014/03/01 - 2014/05/31	Visiting EFSD Albert Renold Travel Fellowship	Petr Zouhar
2009/01/01 - 2012/06/06	NMR studies of metabolism	Teresa Cardoso Delgado

Distinções

Prémio

2008	GSK IdeaSpring Prize, Most Promising Innovative Technology
2005	Portuguese Society of Diabetes-JABA Industry Hargreaves Prize, Best Research Study on Diabetes in Portugal in 2004
2005	Best Oral Communication in the field of Clinical Research Sociedade Portuguesa de Diabetologia, Portugal