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Dr. Tiago G. Fernandes holds a PhD in Biotechnology (2009) from Instituto Superior Técnico (IST), Universidade de Lisboa, in collaboration with Rensselaer Polytechnic Institute (NY, USA). He is currently an Assistant Professor at IST and a Research Scientist at the Institute for Bioengineering and Biosciences (iBB) in Lisbon, Portugal. In 2020, he was Invited Faculty at the Department of Biomedical Engineering and Wisconsin Institute for Discovery, University of Wisconsin-Madison (USA). Dr. Fernandes has authored over 50 peer-reviewed research articles, contributed to 10 book chapters, and edited two books in the fields of stem cell bioengineering, tissue engineering, and bioprocessing. His scientific excellence has been recognized with several awards, including the prestigious Malcolm Lilly Award (2008) from the European Society of Biochemical Engineering Science, which honors outstanding young researchers in bioprocessing engineering. His research focuses on integrating engineering and biology to guide stem cell fate and microenvironment design, with the goal of developing advanced in vitro models for organogenesis, disease modeling, and tissue regeneration. His work has contributed to the development of artificial cellular niches that better mimic in vivo extracellular environments, facilitating the controlled differentiation and maturation of human pluripotent stem cells (hPSCs). By employing systems-based approaches, his research aims to advance cell-based therapies and enhance tissue engineering strategies for regenerative medicine. Research Interests and Expertise - Mechanistic Understanding of Human Organogenesis – Development of in vitro platforms to study lineage commitment and tissue maturation of hPSCs. - Tissue and Organ Bioassembly – Modeling human central nervous system development, with a focus on cerebellar organoids for studying neural differentiation. - Brain Microvasculature and the Blood-Brain Barrier – Investigating vascularization mechanisms and the establishment of the neural-vascular unit in brain organoids. - Hepatic Tissue Engineering and Definitive Endoderm Commitment – Exploiting the organogenic capacity of hPSCs to generate bioassembled 3D liver microtissues, with a focus on hepatic differentiation and functional maturation. By combining stem cell biology, biofabrication, and transcriptomics, Dr. Fernandes continues to push the boundaries of regenerative medicine, contributing to the development of innovative models for studying human development, disease, and therapeutic applications.
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Identificação

Identificação pessoal

Nome completo
TIAGO PAULO GONÇALVES PINHEIRO FERNANDES

Nomes de citação

  • Fernandes, Tiago G.

Identificadores de autor

Ciência ID
B217-60F0-B33B
ORCID iD
0000-0002-4651-2832

Endereços de correio eletrónico

  • tfernandes@tecnico.ulisboa.pt (Profissional)

Websites

Domínios de atuação

  • Ciências Médicas e da Saúde - Biotecnologia Médica - Biotecnologia Aplicada à Saúde
  • Ciências da Engenharia e Tecnologias - Biotecnologia Industrial - Tecnologias de BioProcessamento
  • Ciências Médicas e da Saúde - Biotecnologia Médica - Biotecnologia Aplicada à Saúde
  • Ciências Médicas e da Saúde - Biotecnologia Médica - Tecnologias que envolvem a Manipulação de Células,Tecidos,Órgãos ou todo o Organismo
  • Ciências da Engenharia e Tecnologias - Outras Ciências da Engenharia e Tecnologias
  • Ciências Médicas e da Saúde - Biotecnologia Médica - Biomateriais
  • Ciências da Engenharia e Tecnologias - Engenharia Médica - Tecnologia Laboratorial

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Francês Utilizador elementar (A1) Utilizador independente (B1) Utilizador elementar (A1) Utilizador elementar (A1)
Formação
Grau Classificação
2018/02/05
Concluído
 Specialization in Systems Biology and Biotechnology, on Coursera (Outros)
Icahn School of Medicine at Mount Sinai, Estados Unidos
2017/01/28
Concluído
 Integrated Analysis in Systems Biology, on Coursera (Outros)
Icahn School of Medicine at Mount Sinai, Estados Unidos
2016/11/22
Concluído
 Dynamical Modeling Methods for Systems Biology, on Coursera (Outros)
Icahn School of Medicine at Mount Sinai, Estados Unidos
2016/06/20
Concluído
 Network Analysis in Systems Biology, on Coursera (Outros)
Icahn School of Medicine at Mount Sinai, Estados Unidos
2016/03/31
Concluído
 Experimental Methods in Systems Biology, on Coursera (Outros)
Icahn School of Medicine at Mount Sinai, Estados Unidos
2016/01/27
Concluído
 Introduction to Systems Biology, on Coursera (Outros)
Icahn School of Medicine at Mount Sinai, Estados Unidos
2009
Concluído
 Biotecnologia (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
"Cell-based microarray systems for stem cell expansion and differentiation" (TESE/DISSERTAÇÃO)
 n/a
2006
Concluído
 Biotecnologia (Doutoramento)
Especialização em Sem especialidade
Universidade de Lisboa Instituto Superior Técnico, Portugal
"Cell-based Microarray Systems for Stem Cell Expansiond Differentiaton" (TESE/DISSERTAÇÃO)
2004
Concluído
 Engª Biológica (Licenciatura)
Universidade de Lisboa Instituto Superior Técnico, Portugal
"Efeito da diminuição da temperatura de gelificação do gritz de milho na qualidade do mosto e cerveja" (TESE/DISSERTAÇÃO)
 15 (in a 20 scale)
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2015/01/01 - 2016/12/31 Investigador Auxiliar (carreira) (Investigação) Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal
2010/01/01 - 2014/12/31 Pós-doutorado (Investigação) Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal
2012 - 2012 Estagiário de Investigação (Investigação) Dublin City University, Irlanda
2005/03/01 - 2005/12/31 Assistente de Investigação (carreira) (Investigação) Universidade de Lisboa Instituto Superior Técnico, Portugal

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2017/01/01 - Atual Professor Auxiliar (Docente Universitário) Universidade de Lisboa Instituto Superior Técnico, Portugal
2020/01 - 2020/09 Professor Visitante (Docente Universitário) University of Wisconsin-Madison, Estados Unidos

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2006/01/01 - 2009/12/31 PhD Student Universidade de Lisboa Instituto Superior Técnico, Portugal
2006/09/01 - 2008/09/01 Visiting PhD Student Rensselaer Polytechnic Institute, Estados Unidos
2004/12/01 - 2005/03/01 Trainee Universidade de Lisboa Instituto Superior Técnico, Portugal
2004/03/01 - 2004/10/31 Trainee Sociedade Central de Cervejas, Portugal
Projetos

Bolsa

Designação Financiadores
2021/01/01 - Atual Exploring new therapeutic strategies for Angelman syndrome: A disease modelling approach based on 3D cerebellar organoids derived from patient iPSCs
PMJMCD 2019
Em curso
2021/01 - 2025/12 Instituto para a Saúde e a Bioeconomia
168280UID
 Fundação para a Ciência e a Tecnologia
2017/04 - 2024/03 The DISCOVERIES CENTRE for REGENERATIVE and PRECISION MEDICINE
H2020-WIDESPREAD-01-2016-2017-TeamingPhase2
Investigador
European Commission
2021/01 - 2023/12 RNA mis-splicing in hypertrophic cardiomyopathy: opportunities for diagnosis and therapy
HR20-00322
Investigador
Caixabank SA
2019/01 - 2019/12 Instituto de Bioengenharia e Biociências
154778UID
 Fundação para a Ciência e a Tecnologia
2009/04 - 2012/06 Materiais e sistemas inteligentes para libertação controlada de moléculas bioactivas, expansão celular e monitorização de ambientes celulares.
83907PRJ
 Fundação para a Ciência e a Tecnologia

Projeto

Designação Financiadores
2021/01/01 - 2025/12/31 Institute for Health and Bioeconomy
LA/P/0140/2020
10.54499/LA/P/0140/2020
Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal

Universidade Nova de Lisboa, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Unidade de Ciências Biomoleculares Aplicadas, Portugal

Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal

INESC Microsistemas e Nanotecnologias, Portugal

Universidade Nova de Lisboa Associação para a Inovação e Desenvolvimento da FCT, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2021/02/01 - 2024/01/31 New technologies for Stem cell Manufacturing bioprocess monitoring and ARTificial intelligence-based modeling
PTDC/EQU-EQU/3853/2020
Investigador
Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal

Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal

Instituto de Telecomunicações, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2019/01/01 - 2023/12/31 Applied Molecular Biosciences Unit
UIDP/04378/2020
10.54499/UIDP/04378/2020
UIDB/04378/2020
10.54499/UIDB/04378/2020
Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal

Universidade Nova de Lisboa, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Universidade do Porto, Portugal

Unidade de Ciências Biomoleculares Aplicadas, Portugal

Universidade do Porto Instituto de Ciências Tecnologias e Agroambiente, Portugal

Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal

INESC Microsistemas e Nanotecnologias, Portugal

Universidade Nova de Lisboa Associação para a Inovação e Desenvolvimento da FCT, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2018/10/01 - 2022/09/30 Organoid Engineering for Production of 3D Cardiovascular Microtissues from Human Induced Pluripotent Stem Cells for Cardiotoxicity Assays
PTDC/EMD-TLM/29728/2017
Investigador
Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2018/10/01 - 2022/09/30 Upscaling the Production of Human Pluripotent Stem Cell-derived Cardiomyocytes using Vertical-Wheel Bioreactors
PTDC/EQU-EQU/29653/2017
Investigador
Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2018/06/01 - 2021/05/31 Generation of gene-edited cerebellar organoids for ataxia research
PTDC/BTM-SAL/29298/2017
Investigador
Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal

Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2016/12/01 - 2021/01/31 Accelerating progress toward the new era of precision medicine
SAICTPAC/0021/2015
Investigador
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal

Instituto de Engenharia de Sistemas e Computadores Investigação e Desenvolvimento em Lisboa, Portugal

Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2020/02/01 - 2020/07/31 In vitro vascularization of neural organoids
SFRH/BSAB/150269/2019
Provided by PTCRIS: SFRH/BSAB/150269/2019
Investigador responsável
Fundação para a Ciência e a Tecnologia
Concluído
2019/01/01 - 2019/12/31 Institute for Bioengineering and Biosciences
UID/BIO/04565/2019
Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal

Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2014/12/01 - 2018/05/31 CARDIOSTEM- Engineered cardiac tissues and stem cell-based therapies for cardiovascular applications
MITP-TB/ECE/0013/2013
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Instituto Nacional de Engenharia Biomédica, Portugal

Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal

Centro Hospitalar de Lisboa Central EPE, Portugal

Instituto de Biologia Experimental e Tecnológica, Portugal

Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2013/01/01 - 2016/01/25 SIGNALING DYNAMICS IN HUMAN PLURIPOTENT STEM CELLS: SYSTEMS BIOENGINEERING APPROACHES FOR CONTROLLING STEM CELL FATE
SFRH/BPD/86316/2012
Provided by PTCRIS: SFRH/BPD/86316/2012
Bolseiro de Pós-Doutoramento
Fundação para a Ciência e a Tecnologia
Concluído
2014/01/01 - 2014/12/31 Bioengineering the Neural Commitment of Human Pluripotent Stem Cells: Rational Approaches for the Clinical-Grade Production of Neuronal Cells
EXPL/BBB-EBI/0294/2013
133316
Provided by PTCRIS: 133316
Investigador responsável
Instituto de Biotecnologia e Bioengenharia, Portugal

Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal
Fundação para a Ciência e a Tecnologia

Fundação para a Ciência e a Tecnologia, I.P.
Concluído
2012/01/01 - 2014/12/31 StemPure - Bioprocess for Production and Purification of Human Pluripotent Stem Cell-derived Neural Cells for Regenerative Medicine Applications
PTDC/EBB-BIO/122504/2010
Investigador
Instituto de Biotecnologia e Bioengenharia, Portugal

Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2010/04/01 - 2013/09/30 StemCellQCM - Acoutic detectors for stem cell adhesion and differentiation
PTDC/SAU-BEB/105189/2008
Investigador
Instituto de Biotecnologia e Bioengenharia, Portugal

Universidade do Algarve, Portugal

Universidade de Lisboa Instituto Superior Técnico, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2010/01/01 - 2012/12/31 DESIGN AND FABRICATION OF ARTIFICIAL CELLULAR NICHES FOR DECONSTRUCTING HUMAN STEM CELL PLURIPOTENCY
SFRH/BPD/65439/2009
Provided by PTCRIS: SFRH/BPD/65439/2009
Bolseiro de Pós-Doutoramento
Fundação para a Ciência e a Tecnologia
Concluído
2010/01/01 - 2012/12/31 Exploring human embryonic stem cell fate using 3-D cellular microarrays
PTDC/EBB-BIO/101088/2008
Investigador
Universidade de Lisboa Instituto Superior Técnico, Portugal

Instituto de Biotecnologia e Bioengenharia, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2010/01/01 - 2012/12/31 Integrated Process for the Expansion and Neural Differentiation of Human Embryonic Stem Cells in Stirred Suspension Bioreactors
PTDC/EQU-ERQ/105277/2008
Investigador
Universidade de Lisboa Instituto Superior Técnico, Portugal

Instituto de Biotecnologia e Bioengenharia, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2006/01/01 - 2009/12/31 EX-VIVO DIFFERENTIATION OF MOUSE EMBRYONIC STEM CELLS IN MICROBIOREACTORS
SFRH/BD/24365/2005
Provided by PTCRIS: SFRH/BD/24365/2005
Bolseiro de Doutoramento
Fundação para a Ciência e a Tecnologia
Concluído
Produções

Publicações

Artigo em conferência
  1. Maranga, Carina; Silva, Teresa P.; Vaz, Sandra H.; Da Rocha, Simão; Fernandes, Tiago G.; Bekman, Evguenia P.; Cabral, Joaquim M. S.. "Disease modeling of Angelman syndrome using hiPSC-derived cerebellar organoids". Trabalho apresentado em XVI Meeting of the Portuguese Society for Neuroscience, 2019.
    10.3389/conf.fncel.2019.01.00041
  2. Miranda, C.C.; Pascoal, J.F.; Fernandes, T.G.; Diogo, M.M.; Cabral, J.M.S.. "Expansion and neural commitment of human pluripotent stem cells as 3D suspension aggregates". 2014.
  3. Fernandes, T.G.; Diogo, M.M.; Dordick, J.S.; Cabral, J.M.S.. "Exploring embryonic stem cell fate using cellular microarrays". 2011.
    10.1109/ENBENG.2011.6026038
  4. Fernandes, T.G.; Diogo, M.M.; Fernandes-Platzgummer, A.; Da Silva, C.L.; Cabral, J.M.S.. "Effect of hypoxia on proliferation and neural commitment of embryonic stem cells at different stages of pluripotency". 2011.
    10.1109/ENBENG.2011.6026039
Artigo em revista
  1. Boutom SM; Silva TP; Palecek SP; Shusta EV; Fernandes TG; Ashton RS. "Central nervous system vascularization in human embryos and neural organoids.". Cell reports (2024): http://europepmc.org/abstract/med/39693224.
    10.1016/j.celrep.2024.115068
  2. Bahram Sangani N; Koetsier J; Gomes AR; Diogo MM; Fernandes TG; Bouwman FG; Mariman ECM; et al. "Involvement of extracellular vesicle microRNA clusters in developing healthy and Rett syndrome brain organoids.". Cellular and molecular life sciences : CMLS (2024): http://europepmc.org/abstract/med/39305343.
    10.1007/s00018-024-05409-7
  3. Branco A; Rayabaram J; Miranda CC; Fernandes-Platzgummer A; Fernandes TG; Sajja S; da Silva CL; Vemuri MC. "Advances in ex vivo expansion of hematopoietic stem and progenitor cells for clinical applications.". Frontiers in bioengineering and biotechnology (2024): http://europepmc.org/abstract/med/38846805.
    10.3389/fbioe.2024.1380950
  4. Chiara Scodellaro; Raquel R. Pina; Frederico Castelo Ferreira; Paola Sanjuan-Alberte; Tiago G. Fernandes. "Unlocking the Potential of Stem Cell Microenvironments In Vitro". Bioengineering (2024): https://doi.org/10.3390/bioengineering11030289.
    10.3390/bioengineering11030289
  5. Tenreiro, M.F.; Branco, M.A.; Cotovio, J.P.; Cabral, J.M.S.; Fernandes, T.G.; Diogo, M.M.. "Advancing organoid design through co-emergence, assembly, and bioengineering". Trends in Biotechnology (2023): http://www.scopus.com/inward/record.url?eid=2-s2.0-85146345562&partnerID=MN8TOARS.
    10.1016/j.tibtech.2022.12.021
  6. Soares, B.X.; Miranda, C.C.; Fernandes, T.G.. "Systems bioengineering approaches for developmental toxicology". Computational and Structural Biotechnology Journal 21 (2023): 3272-3279. http://www.scopus.com/inward/record.url?eid=2-s2.0-85161606634&partnerID=MN8TOARS.
    10.1016/j.csbj.2023.06.005
  7. Fernandes, T.G.. "Organoids as complex (bio)systems". Frontiers in Cell and Developmental Biology 11 (2023): http://www.scopus.com/inward/record.url?eid=2-s2.0-85170220679&partnerID=MN8TOARS.
    10.3389/fcell.2023.1268540
  8. Tiago G. Fernandes. "Design and Fabrication of Artificial Stem Cell Niches". Bioengineering (2022): https://doi.org/10.3390/bioengineering9120813.
    10.3390/bioengineering9120813
  9. Tiago P. Dias; Sandra N. Pinto; Sandra Carvalho; Tiago G. Fernandes; Fábio Fernandes; Maria Margarida Diogo; Maria C. Peleteiro; Manuel Prieto; Joaquim M. S. Cabral. "Cost-Effective Mechanical Aggregation of Cardiac Progenitors and Encapsulation in Matrigel Support Self-Organization in a Dynamic Culture Environment". International Journal of Molecular Sciences (2022): https://doi.org/10.3390/ijms232415785.
    10.3390/ijms232415785
  10. Tiago P. Dias; Tânia Baltazar; Sandra N. Pinto; Tiago G. Fernandes; Fábio Fernandes; Maria Margarida Diogo; Manuel Prieto; Joaquim M. S. Cabral; Ren-Ke Li. "Xeno-Free Integrated Platform for Robust Production of Cardiomyocyte Sheets from hiPSCs". Stem Cells International (2022): https://doi.org/10.1155/2022/4542719.
    10.1155/2022/4542719
  11. "A Dynamic 3D Aggregate-Based System for the Successful Expansion and Neural Induction of Human Pluripotent Stem Cells". Frontiers in Cellular Neurosciences (2022): https://www.frontiersin.org/articles/10.3389/fncel.2022.838217/abstract.
    10.3389/fncel.2022.838217
  12. Borges, A.C.; Broersen, K.; Leandro, P.; Fernandes, T.G.. "Engineering Organoids for in vitro Modeling of Phenylketonuria". Frontiers in Molecular Neuroscience 14 (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85123361416&partnerID=MN8TOARS.
    10.3389/fnmol.2021.787242
  13. Teresa P. Silva; Rui Sousa-Luís; Tiago G. Fernandes; Evguenia P. Bekman; Carlos A. V. Rodrigues; Sandra H. Vaz; Leonilde M. Moreira; et al. "Transcriptome profiling of human pluripotent stem cell-derived cerebellar organoids reveals faster commitment under dynamic conditions". Biotechnology and Bioengineering (2021): https://doi.org/10.1002/bit.27797.
    10.1002/bit.27797
  14. Lei Y; Willerth SM; Fernandes TG. "Editorial: Stem Cell Systems Bioengineering.". Frontiers in bioengineering and biotechnology (2021): http://europepmc.org/abstract/med/34026746.
    10.3389/fbioe.2021.693107
  15. Ana Rita Gomes; Tiago G. Fernandes; Joaquim M.S. Cabral; Maria Margarida Diogo. "Modeling Rett Syndrome with Human Pluripotent Stem Cells: Mechanistic Outcomes and Future Clinical Perspectives". International Journal of Molecular Sciences (2021): https://doi.org/10.3390/ijms22073751.
    10.3390/ijms22073751
  16. Ana Rita Gomes; Nasim Bahram Sangani; Tiago G. Fernandes; M. Margarida Diogo; Leopold M. G. Curfs; Chris P. Reutelingsperger. "Extracellular Vesicles in CNS Developmental Disorders". International Journal of Molecular Sciences (2020): https://doi.org/10.3390/ijms21249428.
    10.3390/ijms21249428
  17. Gomes AR; Fernandes TG; Vaz SH; Silva TP; Bekman EP; Xapelli S; Duarte S; et al. "Modeling Rett Syndrome With Human Patient-Specific Forebrain Organoids.". Frontiers in cell and developmental biology (2020): http://europepmc.org/abstract/med/33363173.
    10.3389/fcell.2020.610427
  18. Padrão I; Fernandes CSM; Esteves C; Fernandes T; Pina AS; Roque ACA. "Versatile and Tunable Poly(Ethylene Glycol)-Based Hydrogels Crosslinked through the Ugi Reaction.". ChemPlusChem (2020): http://europepmc.org/abstract/med/33369274.
    10.1002/cplu.202000743
  19. Branco MA; Dias TP; Cotovio JP; Rodrigues CAV; Fernandes TG; Cabral JMS; Diogo MM. "3D Microwell Platform for Cardiomyocyte Differentiation of Human Pluripotent Stem Cells.". Methods in molecular biology (Clifton, N.J.) (2020): http://europepmc.org/abstract/med/33145715.
    10.1007/7651_2020_336
  20. Fernandes, Tiago G.. "Natural Multimerization Rules the Performance of Affinity-Based Physical Hydrogels for Stem Cell Encapsulation and Differentiation.". Biomacromolecules (2020): https://doi.org/10.1021/acs.biomac.0c00473.
    10.1021/acs.biomac.0c00473
  21. Fernandes, Tiago G.. "Scalable Generation of Mature Cerebellar Organoids from Human Pluripotent Stem Cells and Characterization by Immunostaining.". Journal of visualized experiments : JoVE (2020): https://doi.org/10.3791/61143.
    10.3791/61143
  22. João P. Cotovio; Tiago G. Fernandes. "Production of Human Pluripotent Stem Cell-Derived Hepatic Cell Lineages and Liver Organoids: Current Status and Potential Applications". Bioengineering 7 2 (2020): 36-36. https://doi.org/10.3390/bioengineering7020036.
    10.3390/bioengineering7020036
  23. Silva, Teresa P.; Bekman, Evguenia P.; Fernandes, Tiago G.; Vaz, Sandra H.; Rodrigues, Carlos A. V.; Diogo, Maria Margarida; Cabral, Joaquim M. S.; Carmo-Fonseca, Maria. "Maturation of Human Pluripotent Stem Cell-Derived Cerebellar Neurons in the Absence of Co-culture". Frontiers in Bioengineering and Biotechnology 8 (2020): http://dx.doi.org/10.3389/fbioe.2020.00070.
    10.3389/fbioe.2020.00070
  24. Maranga C; Fernandes TG; Bekman E; Teixeira da Rocha S. "Angelman Syndrome: a journey through the brain.". The FEBS journal (2020): http://europepmc.org/abstract/med/32087041.
    10.1111/febs.15258
  25. Miranda CC; Fernandes TG; Diogo MM; Cabral JMS. "Human Pluripotent Stem Cells: Applications and Challenges for Regenerative Medicine and Disease Modeling.". Advances in biochemical engineering/biotechnology (2020): http://europepmc.org/abstract/med/31740987.
    10.1007/10_2019_117
  26. Fernandes, C.S.M., Pina, A.S., Moura Barbosa, A.J., Padrão, I., Duarte, F., Teixeira, C.A.S., Alves, V., et al.. "Affinity-triggered assemblies based on a designed peptide-peptide affinity pair.". Biotechnology journal 14 11 (2019): e1800559. https://doi.org/10.1002/biot.201800559.
    10.1002/biot.201800559
  27. Tiago G. Fernandes; Ricardo P. Baptista; Howard Kim. "Engineering Cell Systems". Stem Cells International (2019): https://doi.org/10.1155/2019/4685137.
    10.1155/2019/4685137
  28. Teresa P. Silva; João P. Cotovio; Evguenia Bekman; Maria Carmo-Fonseca; Joaquim M. S. Cabral; Tiago G. Fernandes. "Design Principles for Pluripotent Stem Cell-Derived Organoid Engineering". Stem Cells International 2019 (2019): 1-17. https://doi.org/10.1155/2019/4508470.
    10.1155/2019/4508470
  29. Branco, M.A.; Cotovio, J.P.; Rodrigues, C.A.V.; Vaz, S.H.; Fernandes, T.G.; Moreira, L.M.; Cabral, J.M.S.; Diogo, M.M.. "Transcriptomic analysis of 3D Cardiac Differentiation of Human Induced Pluripotent Stem Cells Reveals Faster Cardiomyocyte Maturation Compared to 2D Culture". Scientific Reports 9 1 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85068061234&partnerID=MN8TOARS.
    10.1038/s41598-019-45047-9
  30. Dias, T.P.; Fernandes, T.G.; Diogo, M.M.; Cabral, J.M.S.. "Multifactorial modeling reveals a dominant role of wnt signaling in lineage commitment of human pluripotent stem cells". Bioengineering 6 3 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85073387087&partnerID=MN8TOARS.
    10.3390/bioengineering6030071
  31. Miranda, C.C.; Fernandes, T.G.; Pinto, S.N.; Prieto, M.; Diogo, M.M.; Cabral, J.M.S.. "A scale out approach towards neural induction of human induced pluripotent stem cells for neurodevelopmental toxicity studies". Toxicology Letters 294 (2018): 51-60. http://www.scopus.com/inward/record.url?eid=2-s2.0-85047137479&partnerID=MN8TOARS.
    10.1016/j.toxlet.2018.05.018
  32. Rodrigues, C.A.; Silva, T.P.; Nogueira, D.E.; Fernandes, T.G.; Hashimura, Y.; Wesselschmidt, R.; Diogo, M.M.; Lee, B.; Cabral, J.M.. "Scalable culture of human induced pluripotent cells on microcarriers under xeno-free conditions using single-use vertical-wheel™ bioreactors". Journal of Chemical Technology and Biotechnology (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85050883098&partnerID=MN8TOARS.
    10.1002/jctb.5738
  33. Miranda, C.C.; Fernandes, T.G.; Diogo, M.M.; Cabral, J.M.S.. "Towards multi-organoid systems for drug screening applications". Bioengineering 5 3 (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85056790027&partnerID=MN8TOARS.
    10.3390/bioengineering5030049
  34. Dias, T.P.; Pinto, S.N.; Santos, J.I.; Fernandes, T.G.; Fernandes, F.; Diogo, M.M.; Prieto, M.; Cabral, J.M.S.. "Biophysical study of human induced Pluripotent Stem Cell-Derived cardiomyocyte structural maturation during long-term culture". Biochemical and Biophysical Research Communications 499 3 (2018): 611-617. http://www.scopus.com/inward/record.url?eid=2-s2.0-85045378556&partnerID=MN8TOARS.
    10.1016/j.bbrc.2018.03.198
  35. Badenes, S.M.; Fernandes, T.G.; Miranda, C.C.; Pusch-Klein, A.; Haupt, S.; Rodrigues, C.A.V.; Diogo, M.M.; Brüstle, O.; Cabral, J.M.S.. "Long-term expansion of human induced pluripotent stem cells in a microcarrier-based dynamic system". Journal of Chemical Technology and Biotechnology 92 3 (2017): 492-503. http://www.scopus.com/inward/record.url?eid=2-s2.0-84990198014&partnerID=MN8TOARS.
    10.1002/jctb.5074
  36. Badenes, S.M.; Fernandes, T.G.; Cordeiro, C.S.M.; Boucher, S.; Kuninger, D.; Vemuri, M.C.; Diogo, M.M.; Cabral, J.M.S.. "Defined essential 8' medium and vitronectin efficiently support scalable xeno-free expansion of human induced pluripotent stem cells in stirred microcarrier culture systems". PLoS ONE 11 3 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84962476807&partnerID=MN8TOARS.
    10.1371/journal.pone.0151264
  37. Badenes, S.M.; Fernandes, T.G.; Rodrigues, C.A.V.; Diogo, M.M.; Cabral, J.M.S.. "Microcarrier-based platforms for in vitro expansion and differentiation of human pluripotent stem cells in bioreactor culture systems". Journal of Biotechnology 234 (2016): 71-82. http://www.scopus.com/inward/record.url?eid=2-s2.0-84980371010&partnerID=MN8TOARS.
    10.1016/j.jbiotec.2016.07.023
  38. Miranda, C.C.; Fernandes, T.G.; Diogo, M.M.; Cabral, J.M.S.. "Scaling up a chemically-defined aggregate-based suspension culture system for neural commitment of human pluripotent stem cells". Biotechnology Journal 11 12 (2016): 1628-1638. http://www.scopus.com/inward/record.url?eid=2-s2.0-85003042306&partnerID=MN8TOARS.
    10.1002/biot.201600446
  39. Badenes, S.M.; Fernandes, T.G.; Cordeiro, C.S.M.; Boucher, S.; Kuninger, D.; Vemuri, M.C.; Diogo, M.M.; Cabral, J.M.S.. "Correction: Defined essential 8™ medium and vitronectin efficiently support scalable xeno-free expansion of human induced pluripotent stem cells in stirred microcarrier culture systems (PLOS ONE (2016)11:5(e0155296)Doi: 10.1371/journal.pone.0151264)". PLoS ONE 11 5 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-85060211680&partnerID=MN8TOARS.
    10.1371/journal.pone.0155296
  40. Miranda, C.C.; Fernandes, T.G.; Pascoal, J.F.; Haupt, S.; Brüstle, O.; Cabral, J.M.; Diogo, M.M.. "Spatial and temporal control of cell aggregation efficiently directs human pluripotent stem cells towards neural commitment". Biotechnology Journal (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84928629732&partnerID=MN8TOARS.
    10.1002/biot.201400846
  41. Fernandes, T.G.. "Engineering at the microscale: A step towards single-cell analysis of human pluripotent stem cells". Biotechnology Journal (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84937500674&partnerID=MN8TOARS.
    10.1002/biot.201500307
  42. Rodrigues, G.M.C.; Rodrigues, C.A.V.; Fernandes, T.G.; Diogo, M.M.; Cabral, J.M.S.. "Clinical-scale purification of pluripotent stem cell derivatives for cell-based therapies". Biotechnology Journal 10 8 (2015): 1103-1114. http://www.scopus.com/inward/record.url?eid=2-s2.0-84938806348&partnerID=MN8TOARS.
    10.1002/biot.201400535
  43. Fernandes, T.G.; Duarte, S.T.; Ghazvini, M.; Gaspar, C.; Santos, D.C.; Porteira, A.R.; Rodrigues, G.M.C.; et al. "Neural commitment of human pluripotent stem cells under defined conditions recapitulates neural development and generates patient-specific neural cells". Biotechnology Journal (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84934300606&partnerID=MN8TOARS.
    10.1002/biot.201400751
  44. Fernandes, T.G.; Rodrigues, C.A.V.; Diogo, M.M.; Cabral, J.M.S.. "Stem cell bioprocessing for regenerative medicine". Journal of Chemical Technology and Biotechnology 89 1 (2014): 34-47. http://www.scopus.com/inward/record.url?eid=2-s2.0-84897050716&partnerID=MN8TOARS.
    10.1002/jctb.4189
  45. Rodrigues, G.M.C.; Matos, A.F.S.; Fernandes, T.G.; Rodrigues, C.A.V.; Peitz, M.; Haupt, S.; Diogo, M.M.; Brüstle, O.; Cabral, J.M.S.. "Integrated Platform for Production and Purification of Human Pluripotent Stem Cell-Derived Neural Precursors". Stem Cell Reviews and Reports 10 2 (2014): 151-161. http://www.scopus.com/inward/record.url?eid=2-s2.0-84897385766&partnerID=MN8TOARS.
    10.1007/s12015-013-9482-z
  46. Barbosa, H.S.C.; Fernandes, T.G.; Dias, T.P.; Diogo, M.M.; Cabral, J.M.S.. "New insights into the mechanisms of embryonic stem cell self-renewal under Hypoxia: A multifactorial analysis approach". PLoS ONE 7 6 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84862219618&partnerID=MN8TOARS.
    10.1371/journal.pone.0038963
  47. Rodrigues, C.A.V.; Fernandes, T.G.; Diogo, M.M.; da Silva, C.L.; Cabral, J.M.S.. "Stem cell cultivation in bioreactors". Biotechnology Advances 29 6 (2011): 815-829. http://www.scopus.com/inward/record.url?eid=2-s2.0-80053449223&partnerID=MN8TOARS.
    10.1016/j.biotechadv.2011.06.009
  48. Fernandes, T.G.; Barbosa, H.S.C.; Diogo, M.M.; Cabral, J.M.S.; Dordick, J.S.. "Stem cell microarrays as novel systems for high-throughput screening applications". Bio Tech International 22 2 (2010): 16-18. http://www.scopus.com/inward/record.url?eid=2-s2.0-79953314506&partnerID=MN8TOARS.
  49. Fernandes, T.G.; Diogo, M.M.; Fernandes-Platzgummer, A.; da Silva, C.L.; Cabral, J.M.S.. "Different stages of pluripotency determine distinct patterns of proliferation, metabolism, and lineage commitment of embryonic stem cells under hypoxia". Stem Cell Research 5 1 (2010): 76-89. http://www.scopus.com/inward/record.url?eid=2-s2.0-77953286613&partnerID=MN8TOARS.
    10.1016/j.scr.2010.04.003
  50. Fernandes, T.G.; Fernandes-Platzgummer, A.M.; da Silva, C.L.; Diogo, M.M.; Cabral, J.M.S.. "Kinetic and metabolic analysis of mouse embryonic stem cell expansion under serum-free conditions". Biotechnology Letters 32 1 (2010): 171-179. http://www.scopus.com/inward/record.url?eid=2-s2.0-72249097517&partnerID=MN8TOARS.
    10.1007/s10529-009-0108-0
  51. Fernandes, T.G.; Kwon, S.-J.; Bale, S.S.; Lee, M.-Y.; Diogo, M.M.; Clark, D.S.; Cabral, J.M.S.; Dordick, J.S.. "Three-dimensional cell culture microarray for high-throughput studies of stem cell fate". Biotechnology and Bioengineering 106 1 (2010): 106-118. http://www.scopus.com/inward/record.url?eid=2-s2.0-77951583526&partnerID=MN8TOARS.
    10.1002/bit.22661
  52. Fernandes, T.G.; Diogo, M.M.; Clark, D.S.; Dordick, J.S.; Cabral, J.M.S.. "High-throughput cellular microarray platforms: applications in drug discovery, toxicology and stem cell research". Trends in Biotechnology 27 6 (2009): 342-349. http://www.scopus.com/inward/record.url?eid=2-s2.0-65549112285&partnerID=MN8TOARS.
    10.1016/j.tibtech.2009.02.009
  53. Fernandes, T.G.; Kwon, S.-J.; Lee, M.-Y.; Clark, D.S.; Cabral, J.M.S.; Dordick, J.S.. "On-chip, cell-based microarray immunofluorescence assay for high-throughput analysis of target proteins". Analytical Chemistry 80 17 (2008): 6633-6639. http://www.scopus.com/inward/record.url?eid=2-s2.0-51549106300&partnerID=MN8TOARS.
    10.1021/ac800848j
  54. Fernandes, A.M.; Fernandes, T.G.; Diogo, M.M.; da Silva, C.L.; Henrique, D.; Cabral, J.M.S.. "Mouse embryonic stem cell expansion in a microcarrier-based stirred culture system". Journal of Biotechnology 132 2 (2007): 227-236. http://www.scopus.com/inward/record.url?eid=2-s2.0-35348996645&partnerID=MN8TOARS.
    10.1016/j.jbiotec.2007.05.031
Capítulo de livro
  1. Rodrigues, A.L.; Fernandes, T.G.; Diogo, M.M.; Cabral, J.M.S.; Dordick, J.S.. "Advanced microtechnologies for high-throughput screening". 149-175. 2019.
  2. Cotovio, J.P.; Fernandes, T.G.; Diogo, M.M.; Cabral, J.M.S.. "Pluripotent stem cell biology and engineering". 1-31. 2019.
  3. Fernandes, T.G.; Diogo, M.M.; Cabral, J.M.S.. "Conclusions and closing remarks". 259-261. 2019.
  4. Rodrigues, C.A.V.; Fernandes, T.G.; Diogo, M.M.; da Silva, C.L.; Cabral, J.M.S.. "Bioreactors for Stem Cell Expansion and Differentiation". 38-1-38-28-38-1-38-28. 2018.
  5. Rodrigues, Carlos A.V.; Fernandes, Tiago G.; Diogo, Maria Margarida; Lobato da Silva, Cláudia; Cabral, Joaquim M.S.. "Bioreactors for Stem Cell Expansion and Differentiation". In The Biomedical Engineering Handbook, Fourth Edition - Molecular, Cellular, and Tissue Engineering, 38-1-38-28. CRC Press, 2015.
    Publicado
  6. Rodrigues, Carlos A.V.; Fernandes, Tiago G.; Diogo, Maria M.; da Silva, Claudia Lobato; Cabral, Joaquim M.S.. "Stem Cell Bioreactors". In UNESCO - Encyclopedia of Life Support Systems (EOLSS), editado por Berovic, M. UNESCO-EOLSS, 2011.
    Publicado
Livro
  1. Fernandes, T.G.; Diogo, M.M.; Cabral, J.M.S.. Engineering strategies for regenerative medicine. 2019.
    10.1016/C2018-0-00059-6
  2. Fernandes, T.G.; Cabral, J.M.S.. Stem-Cell Microscale Platforms for Toxicology Screening. 2018.
  3. Pascoal, J.F.; Fernandes, T.G.; Nierode, G.J.; Diogo, M.M.; Dordick, J.S.; Cabral, J.M.S.. Three-dimensional cell-based microarrays: printing pluripotent stem cells into 3D microenvironments. 2018.
    10.1007/978-1-4939-7792-5_6
  4. Rodrigues, G.M.C.; Fernandes, T.G.; Rodrigues, C.A.V.; Diogo, M.M.; Cabral, J.M.S.. Enrichment and Separation Technologies for Stem Cell-Based Therapies. 2016.
    10.1016/B978-0-444-63265-4.00009-1
  5. Badenes, S.M.; Fernandes, T.G.; Rodrigues, C.A.V.; Diogo, M.M.; Cabral, J.M.S.. Scalable expansion of human-induced pluripotent stem cells in xeno-free microcarriers. 2015.
    10.1007/7651_2014_106
  6. Rodrigues, G.M.C.; Fernandes, T.G.; Rodrigues, C.A.V.; Cabral, J.M.S.; Diogo, M.M.. Purification of human induced pluripotent stem cell-derived neural precursors using magnetic activated cell sorting. 2015.
    10.1007/7651_2014_115
  7. Fernandes, T.G.; Diogo, M.M.; Cabral, J.M.S.. Stem Cell Bioprocessing: For Cellular Therapy, Diagnostics and Drug Development. 2013.
Poster em conferência
  1. Alípio Gomes; Vieira, Adriana; Maranga, Carina; Casanova, Miguel; Laura Steenpass; Cabral, Joaquim; Fernandes, Tiago G.; da Rocha, Simão Teixeira; Bekman, Evguenia P.. "Correction of disease-causing mutation in Angelman syndrome patient derived iPSC line by CRISPR/Cas9". Trabalho apresentado em 12th International Meeting of the Portuguese Society for Stem Cells and Cell therapies, 2022.
  2. Maranga, Carina; Silva, Teresa P.; Vaz, Sandra H.; Cabral, Joaquim; da Rocha, Simão Teixeira; Fernandes, Tiago G.; Bekman, Evguenia P.. "Recapitulating disease features in cerebellar organoids model of Angelman syndrome". Trabalho apresentado em 12th International Meeting of the Portuguese Society for Stem Cells and Cell therapies, 2022.
  3. Cotovio, João P.; Lee, Brian; Cabral, Joaquim; Fernandes, Tiago G.. "A Bridge Between Development and Engineering: Creating Liver Bud Organoids from hiPSCs". Trabalho apresentado em 18th Vienna BioCenter PhD Symposium - Building Bridges, Vienna, Austria, 2021.
  4. Maranga, Carina; Silva, Teresa P.; Vaz, Sandra H.; Cabral, Joaquim M.S; da Rocha, Simão T.; Fernandes, Tiago G.; Bekman, Evguenia. "Modeling Angelman Syndrome with human induced pluripotent stem cell-derived cerebellar organoids". Trabalho apresentado em Vienna Biocenter PhD Symposium 2021 'Building Bridges', 2021.
  5. Cotovio, João P.; Lee, Brian; Cabral, Joaquim; Fernandes, Tiago G.. "Production of Liver Organoids from hiPSCs in Dynamic Suspension Culture". Trabalho apresentado em 4th Doctoral Congress in Engineering - Symposium on Biomedical Engineering, Porto, Portugal, 2021.
  6. Maranga, Carina; Vieira, Adriana A; Fernandes, Tiago G.; Cabral, Joaquim M. S.; da Rocha, Simão T.; Bekman, Evguenia P.. "Brain-in-a-dish approach for studying Angelman Syndrome". Trabalho apresentado em Neuroepigenetics: From Cells to Behaviour and Disease Virtual EMBO Workshop, 2020.
  7. Ana Rita Gomes; Fernandes, Tiago G.; Vaz, Sandra H.; Silva, Teresa P.; Bekman, Evguenia; Xapeli, Sara; Sebastião, AM; Joaquim M.S. Cabral; Diogo, Maria Margarida. "Modelling Rett syndrome with human patient-specific forebrain organoids". Trabalho apresentado em EMBO Symposium on Organoids: Modelling Organ Development and Disease in 3D Culture, 2020.
  8. Maranga, Carina; Silva, Teresa P.; Fernandes, Tiago G.; da Rocha, Simão T.; Bekman, Evguenia P.; Cabral, Joaquim M. S.. "hiPSC-derived cerebellar organoids to model Angelman Syndrome". Trabalho apresentado em Organoids: Modelling Organ Development and Disease in 3D culture, Virtual EMBO Conference, 2020.
  9. Silva, Teresa P.; Fernandes, Tiago G.; Bekman, Evguenia P.; Vaz, Sandra H.; Rodrigues, Carlos A.V.; Hashimura, Yas; Jung, S; et al. "Large scale production of cerebellar organoids from human pluripotent stem cells using the novel Vertical-Wheel single-use bioreactors". Trabalho apresentado em 7th International Conference on Stem Cell Engineering, Barcelona, Spain, 2019.
  10. Branco, Mariana A.; Cotovio, João P.; Rodrigues, Carlos A.V.; Vaz, Sandra H.; Fernandes, Tiago G.; Moreira, Leonilde M.; Cabral, Joaquim M. S.; Diogo, Maria Margarida. "Transcriptomic analysis of 3D Cardiac Differentiation of Human Induced Pluripotent Stem Cells Reveals Faster Maturation Compared to 2D Culture". Trabalho apresentado em Advanced Cell Therapies and Tissue Engineering, 2019.
  11. Maranga, Carina; Silva, Teresa P.; Vaz, Sandra H.; Teixeira da Rocha, Simão; Fernandes, Tiago G.; Bekman, Evguenia P.; Cabral, Joaquim M. S.. "Cerebellar organoids derived from human pluripotent stem cells to model Angelman Syndrome". Trabalho apresentado em International Meeting of the Portuguese Society for Stem Cells and Cell Therapies, Lisbon, Portugal, 2019.
  12. Saraiva J.E; Fernandes, Tiago G.; Branco, Mariana A.; Cotovio, João P.; Gomes, Ana R.; Rodrigues, Carlos A.V.; Moreira, Leonilde M.; Diogo, Maria Margarida; Cabral, Joaquim M. S.. "Population-level dynamics of human pluripotent stem cell fate transitions". Trabalho apresentado em 11th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies 2019, 2019.
  13. Silva, Teresa P.; Fernandes, Tiago G.; Bekman, Evguenia P.; Vaz, Sandra H.; Rodrigues, Carlos A.V.; Hashimura, Y.; Jung, S.; et al. "Scalable generation of cerebellar neurons from pluripotent stem cells". Trabalho apresentado em ECI Advancing Manufacture of Cell and Gene Therapies VI, 2019.
  14. Silva, Teresa P.; Fernandes, Tiago G.; Bekman, Evguenia P.; Vaz, Sandra H.; Rodrigues, Carlos A.V.; Hashimura, Yas; Jung, S; et al. "Scalable generation of mid-hindbrain organoids from human pluripotent stem cells". Trabalho apresentado em EMBO Symposium on Organoids: Modelling Organ Development and Disease in 3D Culture, Heidelberg, Germany, 2018.
  15. Rodrigues, Carlos A.V.; Silva, Teresa P.; Fernandes, Tiago G.; Hashimura, Y.; Wesselschmidt, Robin; Diogo, Maria Margarida; Lee, B.; Cabral, Joaquim M.S.. "Scalable expansion of human induced pluripotent cells on microcarriers using single-use vertical-wheel™ bioreactors". Trabalho apresentado em 10th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies (SPCE-TC), 2017.
  16. Rodrigues, Carlos A.V.; Silva, Teresa P.; Fernandes, Tiago G.; Hashimura, Yas; Wesselschmidt, Robin; Diogo, Maria Margarida; Lee, Brian; Cabral, Joaquim M. S.. "Scalable expansion of human induced pluripotent cells on microcarriers using single-used vertical-wheel bioreactors". Trabalho apresentado em 10th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies, 2017.
  17. Rodrigues, Carlos A.V.; Fernandes, Tiago G.; Giroux, D.; Hashimura, Y.; Wesselschmidt, R.; Diogo, Maria M.; Lee, B.; Cabral, Joaquim M.S.. "Development Of A Scale-Down Approach To The Scalable Culture Of Induced Pluripotent Stem Cells On Microcarriers Using Single-Use Vertical-WheelTM Bioreactors Under Xeno-Free Conditions". Trabalho apresentado em ECI Scale-up and Manufacturing of Cell-based Therapies V, 2017.
  18. Silva, Teresa P.; Fernandes, Tiago G.; Bekman, Evguenia P.; Rodrigues, Carlos A.V.; Diogo, Maria Margarida; Carmo-Fonseca, Maria; Cabral, Joaquim M.S.. "Cerebellar differentiation and Purkinje cell maturation from Human Induced Pluripotent Stem Cells". Trabalho apresentado em International Conference on Stem Cell Engineering, 2016.
  19. Rodrigues, Carlos A.V.; Fernandes, Tiago G.; Giroux, D.; Hashimura, Y.; Wesselschmidt, R.; Diogo, Maria Margarida; Lee, B.; Cabral, Joaquim M.S.. "Induced Pluripotent Cell Culture Using Single-Use Vertical-Wheel Bioreactors Under Xeno-Free Conditions". Trabalho apresentado em 20th Annual Regenerative Medicine Workshop, 2016.
  20. Fernandes-Platzgummer, Ana; Fernandes, Tiago G.; Diogo, Maria Margarida; Lobato da Silva, C.; Dordick, J.S.; Cabral, Joaquim M. S.. "Effects of low oxygen tension on mouse embryonic stem cell expansion". Trabalho apresentado em 7th ISSCR Annual Meeting, Barcelona, Spain, 2009.
Resumo em conferência
  1. Rodrigues, Carlos A.V.; Nogueira, Diogo; Silva, Teresa P.; Fernandes, Tiago G.; Bekman, Evguenia; Hashimura, Y.; Jung, S.; et al. "Human Induced Pluripotent Stem Cell Culture in Vertical-Wheel Bioreactors". Trabalho apresentado em Virtual ESBES 2020, 2020.
    Publicado
  2. Rodrigues, Carlos A.V.; Rodrigues, André L.; Silva, Teresa P.; Fernandes, Tiago G.; Hashimura, Y.; Wesselschmidt, R.; Diogo, Maria M.; Lee, B.; Cabral, Joaquim M.S.. "Scalable microcarrier-based systems for pluripotent stem cell expansion". Trabalho apresentado em Stem Cell Community Day, Dusseldorf, 2018.
    Publicado
  3. Silva, Teresa P.; Bekman, Evguenia; Fernandes, Tiago G.; Rodrigues, Carlos A.V.; Diogo, Maria M.; Cabral, Joaquim M.S.; Carmo-Fonseca, M.. "Cerebellar differentiation and maturation from Human Induced Pluripotent Stem Cells". Trabalho apresentado em 10th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies, Covilhã, 2017.
    Publicado
  4. Silva, Teresa P.; Bekman, Evguenia P.; Fernandes, Tiago G.; Rodrigues, Carlos A.V.; Diogo, Maria Margarida; Cabral, Joaquim M.S.; Carmo-Fonseca, Maria. "3D Cerebellar differentiation and Purkinje cell maturation from Human Induced Pluripotent Stem Cells". Trabalho apresentado em EMBO Symposium on Organoids: Modelling Organ Development and Disease in 3D Culture, Heidelberg, 2016.
    Publicado
  5. Miranda, Cláudia C.; Fernandes, Tiago G.; Diogo, Maria Margarida; Cabral, Joaquim M. S.. "Upscaling Neural Commitment of Human Pluripotent Stem Cells Using Dual SMAD Inhibition in Suspension Conditions". Trabalho apresentado em 10th European Symposium on Biochemical Engineering Sciences, Dublin, 2016.
  6. Cabral, Joaquim M. S.; Diogo, Maria Margarida; Lobato da Silva, C.; Fernandes-Platzgummer, Ana; Fernandes, Tiago G.; Henrique, Domingos. "Optimization and Integration of the Expansion and Neural Commitment of Mouse Embryonic Stem Cells". Trabalho apresentado em 6th European Symposium on Biochemical Engineering Science, Salzgurg, 2016.
  7. Diogo, Maria Margarida; Miranda, Cláudia C.; Fernandes, Tiago G.; Pascoal, Jorge F.; Cabral, Joaquim M. S.. "Temporal And Spatial Control Of The Neural Commitment Of Human Pluripotent Stem Cells As Suspension Aggregates". Trabalho apresentado em Scale-Up and Manufacturing of Cell-Based Therapies IV, San Diego, 2015.
  8. Fernandes, Tiago G.; Rodrigues, Carlos A.V.; Miranda, Cláudia C.; Diogo, Maria Margarida; Cabral, Joaquim M. S.. "Towards fully defined conditions for human induced pluripotent stem cell expansion". Trabalho apresentado em MicroBiotec’11, Braga, 2011.
  9. Fernandes-Platzgummer, Ana; Fernandes, Tiago G.; Diogo, Maria Margarida; Lobato da Silva, C.; Henrique, Domingos; Dordick, J.S.; Cabral, Joaquim M. S.. "Micro-scale and Bioreactor Systems for the Expansion of mouse embryonic stem (mES) cells". Trabalho apresentado em CHEMPOR 2008: 10th International Chemical and Biological Engineering Conference, Braga, 2008.
  10. Diogo, Maria Margarida; Fernandes-Platzgummer, Ana; Fernandes, Tiago G.; Lobato da Silva, C.; Henrique, Domingos; Cabral, Joaquim M. S.. "Large-scale and nano-scale approaches for the expansion of mouse embryonic stem (mES) cells". Trabalho apresentado em Third International Meeting of SPCE-TC, Faro, 2008.
  11. Diogo, Maria Margarida; Fernandes-Platzgummer, Ana; Fernandes, Tiago G.; Lobato da Silva, C.; Henrique, Domingos; Cabral, Joaquim M. S.. "Optimization of expansion and neural commitment of mouse embryonic stem cells". Trabalho apresentado em MicroBiotecXXXIII JPG 2007, Lisboa, 2007.
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2019/12 Engineering of Forebrain Organoids from Human Induced Pluripotent Stem Cells for Modeling of Rett Syndrome (RTT) [Contributing author] 7th International Conference on Stem Cell Engineering 2019
Society for Biological Engineering (Barcelona, Espanha)
2019/12 Population-Level Dynamics of Human Pluripotent Stem Cell Fate Transitions [Presenter] 7th International Conference on Stem Cell Engineering 2019
Society for Biological Engineering (Barcelona, Espanha)
2019/10/10 Transcriptomic Analysis of 3D Cardiac Differentiation of Human Induced Pluripotent Stem Cells Reveals Faster Maturation of Cardiomyocytes Compared to 2D Culture [Contributing author] 11th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies
Portuguese Society for Stem Cells and Cell Therapies (Lisbon, Portugal)
2018/12 Transcriptomic Analysis of 3D Cardiac Differentiation of Human Induced Pluripotent Stem Cells Reveals Faster Maturation Compared to 2D Culture [Presenter] International Conference on Stem Cell Engineering 2018
American Institute of Chemical Engineers (AIChE) (Los Angeles, Estados Unidos)
2018/12 Development and Characterization of Brain Region-Specific Organoids from Human Induced Pluripotent Stem Cells for Modelling of Rett Syndrome [Contributing author] International Conference on Stem Cell Engineering 2018
American Institute of Chemical Engineers (AIChE) (Los Angeles, Estados Unidos)
2018/09 Production and characterization of brain region-specific organoids from human induced pluripotent stem cells for modelling of Rett Syndrome [Contributing author] ESBES-12, 12th European Symposium on Biochemical Engineering Science
European Symposium on Biochemical Engineering Science (Lisbon, Portugal)
2018/09 Novel size-controlled 3D aggregate platform for cardiac differentiation of hiPSCs for toxicology assays [Contributing author] ESBES-12, 12th European Symposium on Biochemical Engineering Science
European Symposium on Biochemical Engineering Science
2018/04 Scalable microcarrier-based systems for pluripotent stem cell expansion [Contributing author] Eppendorf Stem Cell Community Day
Eppendorf (Dusseldorf, Alemanha)
2017/10/12 Scalable Expansion of Human Induced Pluripotent Cells on Microcarriers Using Single-Use Vertical-Wheel Bioreactors [Contributing author] 10th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies
Portuguese Society for Stem Cells and Cell Therapies (Covilhã, Portugal)
2017/10/12 Cerebellar differentiation and maturation from Human Induced Pluripotent Stem Cells [Contributing author] 10th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies
Portuguese Society for Stem Cells and Cell Therapies (Covilhã, Portugal)
2016/10/23 Scaling up a Chemically-Defined Aggregate-Based Suspension Culture System for Neural Commitment of Human Pluripotent Stem Cells [Contributing author] International Conference on Stem Cell Engineering 2016
American Institute of Chemical Engineers (AIChE) (Toronto, Canadá)
2016/10/12 3D Cerebellar differentiation and maturation from Human Induced Pluripotent Stem Cells [Contributing author] EMBO Symposium on Organoids: Modelling Organ Development and Disease in 3D Culture
EMBO (Heidelberg, Alemanha)
2016/09 Xeno-free Expansion of Human Induced Pluripotent Stem Cells in Scalable Stirred Microcarrier Culture Systems [Contributing author] European Symposium on Biochemical Engineering Sciences (ESBES) 2016
European Symposium on Biochemical Engineering Science (Dublin, Irlanda)
2016/09 Upscaling Neural Commitment of Human Pluripotent Stem Cells using Dual SMAD Inhibition in Suspension Conditions [Contributing author] European Symposium on Biochemical Engineering Sciences (ESBES) 2016
European Symposium on Biochemical Engineering Science (Dublin, Irlanda)
2016/03/16 Factorial Analysis Of Signaling Pathways Involved In Pluripotency And Lineage Specification Reveals A Dominant Effect Of Wnt Signaling In Mesendoderm Differentiation Of Human Pluripotent Stem Cells [Presenter] 20th Annual Regenerative Medicine Workshop at Hilton Head
(Hilton Head, Estados Unidos)
2015/10/15 Spatial and Temporal Control of Cell Aggregation Efficiently directs Human Pluripotent Stem Cells towards Neural Commitment [Contributing author] 9th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies
Portuguese Society for Stem Cells and Cell Therapies (Oeiras, Portugal)
2015/01/18 Temporal and spatial control of the neural commitment of human pluripotent stem cells as suspension aggregates [Contributing author] Scale-up and Manufacturing of Cell-Based Therapies III
Engineering Conferences International (ECI) (San Diego, Estados Unidos)
2014/09 Integrated Platform for Derivation and Enrichment of Human Pluripotent Stem Cell-Derived Cardiomyocytes: Towards Clinical Applications - Malcolm Lilly Award Lecture [Contributing author] 10th European Symposium on Biochemical Engineering Sciences and 6th International Forum on Industrial Bioprocesses
European Symposium on Biochemical Engineering Science (Lille, França)
2014/03/16 Purification of Human Induced Pluripotent Stem Cell-Derived Neural Progenitors for Regenerative Medicine Applications [Presenter] SBE’s 4th International Conference on Stem Cell Engineering
American Institute of Chemical Engineers (AIChE) (San Diego, Estados Unidos)
2013/04/21 Purification of Human Induced Pluripotent Stem Cell-Derived Neural Progenitors for Regenerative Medicine Applications [Contributing author] 2nd European Congress of Applied Biotechnology
(The Hague, Países Baixos)
2012/10/18 High-Throughput Cellular Microarray Platforms: Applications in Drug Discovery, Toxicology and Stem Cell Research [Invited Lecture, Presenter] Workshop Nano12 - Shaping the Future
(Lisbon, Portugal)
2012/03/25 Multifactorial Analysis of Embryonic Stem Cell Self-Renewal Reveals a Crucial Role of GSK-3-mediated Signaling at Physiological Oxygen Levels [Presenter] 243rd American Chemical Society National Meeting & Exposition
American Chemical Society (ACS) (San Diego, Estados Unidos)
2011/12/02 Towards Fully Defined Culture Systems for Human Induced Pluripotent Stem Cell Expansion [Contributing author] MicroBiotec’11
Portuguese Society of Biotechnology (Braga, Portugal)
2011/04/28 Application of a Central Composite Design for Modeling Mouse Embryonic Stem Cell Self-Renewal at Different O2 Levels [Presenter] 6th International Meeting of the Portuguese Society for Stem Cells and Cell Therapy (SPCE-TC)
Portuguese Society for Stem Cells and Cell Therapies (Cantanhede, Portugal)
2011/03/27 Three-Dimensional Cell Culture Microarray for High-Throughput Studies of Stem Cell Fate [Presenter] 241st American Chemical Society National Meeting & Exposition
American Chemical Society (ACS) (Anaheim, Estados Unidos)
2011/03/01 Exploring Embryonic Stem Cell fate using Cellular Microarrays [Presenter] 1st Portuguese Meeting in Bioengineering
Institute of Electrical and Electronics Engineers ( IEEE (Oeiras, Portugal)
2011/03/01 Effect of Hypoxia on Proliferation and Neural Commitment of Embryonic Stem Cells at Different Stages of Pluripotency [Presenter] 1st Portuguese Meeting in Bioengineering
Institute of Electrical and Electronics Engineers (IEEE) (Oeiras, Portugal)
2010/11/28 Stem Cells: High-Throughput Cellular Microarray Platforms and Applications in Drug Discovery [Invited Lecture, Presenter] 2nd National Meeting on Medicinal Chemistry
Portuguese Chemical Society (Coimbra, Portugal)
2010/10/17 Monitoring Stem Cell Cultivations with NIR Spectroscopy [Contributing author] Federation of Analytical Chemistry and Spectroscopy Societies Conference
Federation of Analytical Chemistry and Spectroscopy Societies (Raleigh, Estados Unidos)
2010/05/02 Effect of Hypoxia on Proliferation and Neural Commitment of Embryonic Stem Cells at Different Stages of Pluripotency [Presenter] SBE’s 2nd International Conference on Stem Cell Engineering
American Institute of Chemical Engineers (AIChE) (Boston, Estados Unidos)
2009/07/29 Multi-Scale Strategies for Embryonic Stem Cell Culture [Contributing author] Ciência 2009
Fundação para a Ciência e a Tecnologia (FCT) (Lisbon, Portugal)
2008/09/07 Exploring Stem Cell Fate Using Three-Dimensional Cellular Microarrays [Presenter] 7th European Symposium on Biochemical Engineering Science - Malcolm Lilly Award Lecture
European Symposium on Biochemical Engineering Science (Faro, Portugal)
2008/09/07 A High-Throughput 3D Cell Microarray to Study Stem Cell Fate [Presenter] 7th European Symposium on Biochemical Engineering Science - Malcolm Lilly Award Lecture
European Symposium on Biochemical Engineering Science (Faro, Portugal)
2008/09/04 Micro-scale and Bioreactor Systems for the Expansion of mouse embryonic stem (mES) cells [Contributing author] CHEMPOR 2008 - 10th International Chemical and Biological Engineering Conference
Ordem dos Engenheiros (the Portuguese Engineers Association) (Braga, Portugal)
2008/04/23 Large-Scale and Nano-Scale Approaches for the Expansion of Mouse Embryonic Stem (mES) Cells [Contributing author] 3rd International Meeting of the Portuguese Society for Stem Cells and Cell Therapy (SPCE-TC)
Portuguese Society for Stem Cells and Cell Therapies (Faro, Portugal)
2008/01/20 A High-Throughput 3D Cell Microarray to Study Stem Cell Fate [Contributing author] SBE’s 1st International Conference on Stem Cell Engineering
American Institute of Chemical Engineers (AIChE) (Coronado Island, Estados Unidos)
2007/11/30 Optimization of Expansion and Neural Commitment of Mouse Embryonic Stem Cells [Contributing author] MicroBiotec’2007
Portuguese Society of Biotechnology (Lisbon, Portugal)
2007/08/19 Tracking Stem Cell Fate Using a Cell-Based Microscale Platform [Presenter] 234th American Chemical Society Fall National Meeting
American Chemical Society (ACS) (Boston, Estados Unidos)
2006/08/27 Optimization and Integration of the Expansion and Neural Commitment of Mouse Embryonic Stem Cells [Contributing author] 6th European Symposium on Biochemical Engineering Science
European Symposium on Biochemical Engineering Science (Salzburg, Áustria)

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2024/01/01 - Atual Modeling neurodevelopmental Rasopathies with hiPSC-derived dorsal forebrain organoids for identification of disease signatures and therapy validation
Coorientador de Mariana Martins
 Bioengenharia (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2024/01/01 - Atual Particle engineering strategies to overcome adverse side effects of inhalation products induced by activation of alveolar macrophages
Orientador de Mykaella Mestre
 Bioengenharia (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2024/01/01 - Atual Lung microphysiological system for predicting the bioavailability of dry powder inhalation (DPI) products
Orientador de Beatriz Gamelas
 Bioengenharia (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2023/01/01 - Atual Integrative Approaches in Human Pluripotent Stem Cell Engineering: Multi-Lineage Differentiation, Organoid Development, and Comparative Transcriptomics
Orientador de Alice Borges
 Ciências Biomédicas (Doutoramento)
Universidade de Lisboa Faculdade de Medicina, Portugal
2021/03 - 2025/03 Modelling Rett Syndrome with brain organoids derived from patient-specific human induced pluripotent stem cells for personalized medicine
Coorientador de Miguel Tenreiro
 Bioengenharia (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2022/02 - 2022/11 Characterization of effects of SNORD87 and SNORD88 on the physiology and aging of skin cells
Coorientador de Marta Luísa Esteves da Rocha
 Biological Engineering (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2022/02 - 2022/11 Using CRISPR-Cas9 to generate an Isogenic Cell Line from Patient-Derived Human Induced Pluripotent Stem Cells to model Niemann-Pick Type C1 Cerebellar Ataxia
Coorientador de João Rafael Camões dos Santos
Biological Engineering (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2022/02 - 2022/11 Modelling and characterizing mitochondria transfer from human Mesenchymal stromal cells to Haematopoietic stem cells
Coorientador de João Maria Restolho Mateus Pinheiro
 Biological Engineering (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2022/02 - 2022/11 Molecular effects of a novel SNCA mutation associated with Parkinson’s disease
Coorientador de Ana Rita Landeiro Filipe de Sousa
 Biological Engineering (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2022/02 - 2022/11 Development of a novel high-throughput 3D liver model, with a focus on iPSC-derived hepatic stellate cells and their co-culture with iPSC-derived hepatocytes
Coorientador de Ana Carolina Correia
 Biological Engineering (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2021/09 - 2022/11 Studying miR-34a mediated gene regulation during hepatic embryogenesis
Coorientador de Madalena Pereira de Freitas
Biotechnology (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2018 - 2022 3D Cellular Microarray Platform for human pluripotent stem cell culture and toxicology screenings
Orientador de André Rodrigues
Bioengenharia (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2018 - 2022 Scalable production of mature neuronal subtypes from cerebellar organoids in dynamic 3D conditions to model Angelman Syndrome
Orientador de Carina Maranga
Bioengenharia (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2018 - 2022 Human liver organoids for in vitro disease modelling and drug screening
Orientador de João Cotovio
 Bioengenharia (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2021/03 - 2021/11 Modelling Angelman syndrome in CRISPR-edited isogenic iPSCs
Coorientador de Alípio Gomes
 Engenharia Biológica (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2021/03 - 2021/11 iPSC-derived mammary organoids to study the onset of malignant transformation triggered by BRCA mutations
Coorientador de Eunice Gonçalves
 Engenharia Biológica (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2020/09 - 2021/11 Engineering the Formation of Vascular Networks in Human Forebrain Organoids
Orientador de Maria Augusta Batista
 Biologia Molecular e Genética (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
2020/03 - 2021/06 Design of a Microfluidic Cell Culture Chamber to Evaluate Sustained Small Molecule Release Methods
Coorientador de David Alves
 Bioengenharia e Nanossistemas (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2020/03 - 2021/01 Engineered Heart Tissues for Cardiovascular Disease Modeling
Coorientador de Beatriz Gamelas
 Engenharia Biológica (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2017 - 2021 Engineering region-specific brain organoids from human induced pluripotent stem cells for disease modelling of neurodevelopmental disorders
Coorientador de Ana Rita Gomes
 Bioengenharia (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2016 - 2020 Affinity induced gels to guide stem cell differentiation
Coorientador de Cláudia Fernandes
 Bioengenharia (Doutoramento)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2019/03 - 2019/11 Effects of AD organoid-derived secretome on microglia phenotypic alterations
Coorientador de Ricardo Paiva
 Engenharia Biológica (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2018 - 2019 Transcriptomic deconvolution of alterations in cellular composition and cell type-specific molecular changes associated with ageing of human tissues
Coorientador de Arthur Schneider
 Biotecnologia (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2018 - 2019 Population-Level Dynamics of Human Pluripotent Stem Cell Fate Transitions
Orientador de Joana Saraiva
 Biologia Molecular e Genética (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
2018 - 2018 Production of ferritin nanocages for the diagnosis and therapy of tumours
Coorientador de Beatriz Pereira
Engenharia Biológica (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2018 - 2018 Vascularization of hiPSC derived cardiac tissues
Coorientador de Lara Mil-Homens
 Engenharia Biológica (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2018 - 2018 Generation of gene-edited cerebellar organoids for disease modelling
Coorientador de Joaquim Godinho
 Engenharia Biomédica (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2018 - 2018 A disease modelling approach for Angelman syndrome based on neuronal differentiation of patient-derived iPSCs
Orientador de Ana Guerreiro
Engenharia Biológica (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2017 - 2018 Definitive Endoderm Induction and Hepatic Differentiation of Human Pluripotent Stem Cells
Orientador de Rodrigo Pedroso
 Biotecnologia (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2015 - 2018 Novel bioengineering strategies for modeling cerebellar ataxias
Coorientador de Teresa Pereira da Silva
 Bioengenharia (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2017 - 2017 Cardiac Differentiation of Human Pluripotent Stem Cells in Scalable Suspension Culture under Chemically Defined Conditions
Orientador de Mariana Pina
 Engenharia Biomédica (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2016 - 2017 Role of Tauroursodeoxycholic Acid during Expansion and Neural Commitment of Human Induced Pluripotent Stem Cells under Chemically-defined Conditions
Orientador de Maria Leonor Matos Resina
 Engenharia Biológica (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2016 - 2017 Uncovering the basis of dynamic Wnt expression patterns in mammary gland development and breast cancer
Coorientador de Cátia Rodrigues Pereira
 Biotecnologia (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2016 - 2016 Derivation, Characterization and Purification of Multipotent Cardiovascular Progenitor Cells Derived from Human Induced Pluripotent Stem Cells
Coorientador de Diogo Nogueira
 Engenharia Biológica (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2016 - 2016 Role of Tauroursodeoxycholic Acid (TUDCA) During Expansion and Neural Commitment of Human Induced Pluripotent Stem Cells (hiPSC) under Chemically-Defined Conditions
Coorientador de Ana Rita Gomes
 Engenharia Biológica (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2016 - 2016 Comprehensive Study of the Stability of Genomic Imprinting During iPSC Reprogramming
Coorientador de João Paulo Lopes
 Engenharia Biomédica (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2016 - 2016 3D microfluidic stem cell cultures
Coorientador de Joana Moura
 Engenharia Biológica (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2016 - 2016 Effect of plant extracts on human skin aging
Coorientador de André Branco
 Engenharia Biológica (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2011 - 2016 Integrated Platform for Expansion and Controlled Neural Differentiation of Human Pluripotent Stem Cells (hPSC) in a Xeno-free chemically-defined Suspension System
Coorientador de Cláudia Miranda
 Biotecnologia (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2011 - 2016 Understanding Signaling Dynamics in Human Pluripotent Stem Cells: A Systems Biology Approach
Coorientador de Tiago Dias
 Biotecnologia (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2015 - 2015 Serum-free and Feeder-free Expansion of a patient-specific Fanconi Anemia Human Induced Pluripotent Stem Cell (hiPSC) line corrected by gene editing
Coorientador de André Silva
 Engenharia Biomédica (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2015 - 2015 Role of Tauroursodeoxycholic Acid during Expansion and Neural Commitment of Human Induced Pluripotent Stem Cells under Chemically-defined Conditions
Coorientador de Joana Pinho
 Engenharia Biomédica (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2014 - 2014 Scalable Expansion of Human induced Pluripotent Stem Cells (hiPSC) under Xeno-free Conditions
Coorientador de Cláudia Cordeiro
 Engenharia Biológica (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2014 - 2014 Rett Syndrome Modeling from Human Induced Pluripotent Stem Cells Using a Monolayer Culture System
Coorientador de Ana Raquel Porteira
 Engenharia Biomédica (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2011 - 2012 Integrated Platform for the Expansion and Neuronal Differentiation of Human Induced Pluripotent Stem (hiPS) Cells
Coorientador de Andreia Matos
 Biotecnologia (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2010 - 2011 Molecular Mechanisms Underlying Modulation of Mouse Embryonic Stem (ES) Cell Self-Renewal under Different Oxygen Tensions
Coorientador de Tiago Dias
 Biotecnologia (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2010 - 2011 Establishment of Culture conditions for Expansion and Neural Differentiation of Human Induced Pluripotent Stem (hiPS) Cells
Coorientador de Cláudia Miranda
 Biotecnologia (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal

Júri de grau académico

Tema
Tipo de participação 		Nome do candidato (Tipo de grau)
Instituição / Organização
2023/01 Modulation and Initiation of Movement by Proprioceptors in Drosophila melanogaster
Vogal
 Alexandra Martins de Medeiros Vieira da Silva (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2022/11 Harnessing the therapeutic potential of activated group 2 innate lymphoid cells in renal diseases
Presidente do júri
 Luana Rodrigues Macedo (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2022/11 Optimization of Hematopoietic Stem/Progenitor Cell - Mesenchymal Stromal Cell Co-cultures
Presidente do júri
 João Ribeiro Henriques (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2022/11 Converting microglia into induced neural stem cells: Toward a transdifferentiation system applicable in vitro and in situ
Presidente do júri
 Miguel de Araújo Godinho Henriques Pereira (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2022/11 iPSC maturation via hyperosmolarity-induced growth arrest to drive hepatocyte differentiation
Arguente principal
 Rita Pires de Almeida (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2022/04 Elucidating mechanisms of damage-induced stem cell activation in the adult Drosophila brain
Vogal
 Mariana Batista Santos (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2022/02 Unveiling new regulators of flow-dependent endothelial cell polarization
Vogal
 Catarina Gonçalves Fonseca (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2021 PhD in Bioengineering and Regenerative Medicine, “Bioprocess development for scalable generation of functional liver micro-tissues/organoids from human pluripotent stem cells”
Vogal
 Saeed A. Alizadeh (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2019 PhD in Bioengineering, MIT-P program, “Development of a 3D microarray platform for the study of hPSC growth and differentiation”
Vogal
 Jorge Pascoal (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2019 PhD in Bioengineering and Regenerative Medicine, “Modeling Radiation Injury and Countermeasure Drug Responses in a Human Intestine Chip”
Vogal
 Sasan Jalili Firoozinezhad (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2019 PhD in Bioengineering and Regenerative Medicine, “Conductive electrospun nanofibers for neuron regeneration”
Vogal
 Fábio Garrudo (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2019 Master of Science Degree in Biological engineering, “Surface modification strategies for microfluidic devices
Arguente principal
 Patrícia Canané (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2018 Master of Science Degree in Bioengineering and Nanosystems, “Peripheral molecular targets for adiposity control”
Arguente principal
 Rui Costa (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2018 Master of Science Degree in Biomedical Engineering, “Influence of 3D bioprinting on cell behavior and capillary formation”
Arguente principal
 Ana Sobreiro (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2018 Master of Science Degree in Biological engineering, “Implementation of hiPSC-ECs in thrombosis-on-a-chip devices
Arguente principal
 João Pedro Simão (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2018 Master of Science Degree in Biotechnology, “Cryopreservation of Plasmodium sporozoites for whole organism vaccination against malaria”
Arguente principal
 Rafael de Sousa (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2017 Master of Science Degree in Bioengineering and Nanosystems, “Optimization of a microfluidic device towards a self-assembled BBB-on-a-chip”
Arguente principal
 Aisen de Sá Vivas (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2017 Master of Science Degree in Molecular Genetics and Biomedicine, “Exploring cell reprogramming techniques for Angelman Syndrome disease modeling”
Arguente principal
 Mariana Joaquim (Mestrado)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2017 Master of Science Degree in Biological engineering, “Strategies for chondrogenic differentiation of human induced pluripotent stem cells”
Arguente principal
 Ana Potes Semião (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2016 PhD in Biotechnology, “Bioprocessing of human pluripotent stem cell-derived neural cells for regenerative medicine applications”
Vogal
 Gonçalo Rodrigues (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2016 Master of Science Degree in Biomedical Engineering, “Fabrication of transparent and electroconductive scaffolds for neural stem cell culture combining 3D printing and conjugated polymers”
Arguente principal
 Alexandre Ribeiro (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2016 Master of Science Degree in Biological engineering, “Effects of varying mechanical cues on the vascular differentiation of induced pluripotent stem cells”
Arguente principal
 Ana Verissímo do Carmo (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2016 Master of Science Degree in Biological engineering, “Quantitative image analysis of cell division dynamics”
Arguente principal
 Diogo Castro Fernandes (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2015 Master of Science Degree in Biological Engineering, “Haematopoietic differentiation of normal and PU.1 mutated murine embryonic stem cells using hydrogel encapsulation in a HARV bioreactor”
Arguente principal
 Joana Soares dos Santos (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2015 Master of Science Degree in Biological Engineering, “Hepatocyte differentiation of induced endodermal progenitor cells compared to human embryonic stem cells”
Arguente principal
 Ana Rita Rosa (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2014 Master of Science Degree in Biological Engineering, “Optimization of culture conditions for artificial blastocysts”
Arguente principal
 Maria Inês Leite (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2014 Master of Science Degree in Biological Engineering, “Generation of liver specific endothelial cells for co-culture with hepatocytes”
Arguente principal
 Filipa Martins Ribeiro (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2014 Master of Science Degree in Biological Engineering, “Cell stiffness assessment based on nuclei morphological response to patterned surfaces”
Arguente principal
 Inês Marques dos Santos (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2013 Master of Science Degree in Biomedical Engineering, “Human mesenchymal stem cell cultivation on natural/synthetic polymeric supports”, ISTécnico, 2013.
Arguente principal
 Tatiana Matos Sirgado (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2013 Master of Science Degree in Bioengineering and Nanosystems, “Bio functionalization of electrospun poly(epslon-caprolactone) nanofibres to promote neural stem cell adhesion, alignment and expansion”
Arguente principal
 Inês Frazão Ferreira (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2013 Master of Science Degree in Biomedical Engineering, “Purification of human induced pluripotent stem cell-derived cells for regenerative medicine applications”
Arguente principal
 Pedro Silva (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2012 Master of Science Degree in Biotechnology, “Expansion of human neural stem cells derived from pluripotent stem cells under xeno-free conditions”
Arguente principal
 Rita Martins (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2012 Master of Science Degree in Biotechnology, “Ex-vivo expansion of human hematopoietic stem/progenitor cells from the umbilical cord blood for cellular therapy”
Arguente principal
 António Soure (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2011 Master of Science Degree in Bioengineering and Nanosystems, “Stem cells in microfluidics – Controlling the cellular environment of microspotted stem cells”
Arguente principal
 David Conceição (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2010 Master of Science Degree in Biomedical Engineering, “Development of Notch signaling biomaterials as a tool to control stem cell behavior”
Arguente principal
 João Ramos Galante (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal

Arbitragem científica em revista

Nome da revista (ISSN) Editora
2019/10 - 2020/05 Frontiers in Bioengineering and Biotechnology (2296-4185) Frontiers Media SA
2018/10 - 2019/03 Stem Cells International (1687-9678) Hindawi Publishing Corporation (Sage-Hindawi Access to Research)

Comissão de avaliação

Descrição da atividade
Tipo de assessoria 		Instituição / Organização Entidade financiadora
2019 - 2021 External evaluator for “Spark Grant”
Avaliador
 Schweizerischer Nationalfonds zur Förderung der wissenschaftlichen Forschung, Suiça Schweizerischer Nationalfonds zur Förderung der wissenschaftlichen Forschung
2019 - 2019 External evaluator for “Preludium-17”
Avaliador
 Narodowe Centrum Nauki, Polónia Narodowe Centrum Nauki
2015 - 2015 External evaluator for “ERC Frontier Research Advanced Grants”
Avaliador
 European Research Council, Bélgica European Research Council
2011 - 2011 External evaluator for “Programa de estímulo à ciência”
Avaliador
 Universidade de Coimbra Faculdade de Medicina, Portugal Universidade de Coimbra Faculdade de Medicina
2010 - 2010 External evaluator for “Open Technologieprogramma”
Avaliador
 Technologiestichting STW, Países Baixos Technologiestichting STW

Consultoria / Parecer

Descrição da atividade Instituição / Organização
2010 - 2014 Consulting services for Smart Cell Biologics, Dublin, Ireland. Theses activities included participation in international scientific meetings, project development, proposal writing and draft of potential patent application. Smart Cell Biologics, Irlanda

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2022/09 - Atual Integrated Biological Engineering Laboratory Biological Engineering (Mestrado) Universidade de Lisboa Instituto Superior Técnico, Portugal
2021/09 - Atual Organ Engineering Bioengineering: Regenerative and Precision Medicine (Mestrado) Universidade de Lisboa Instituto Superior Técnico, Portugal
2021/09 - Atual Tissue Engineering Biomedical Engineering (Mestrado) Universidade de Lisboa Instituto Superior Técnico, Portugal
2021/09 - Atual Topics in Bioengineering Biological Engineering (Mestrado) Universidade de Lisboa Instituto Superior Técnico, Portugal
2017 - Atual Systems Bioengineering Engenharia Biológica (Mestrado integrado) Universidade de Lisboa Instituto Superior Técnico, Portugal
2016 - Atual Introduction to Biomedical Engineering Engenharia Biomédica (Mestrado integrado) Universidade de Lisboa Instituto Superior Técnico, Portugal
2016 - Atual Project in Bioengineering and Nanosystems Bioengenharia e Nanossistemas (Mestrado) Universidade de Lisboa Instituto Superior Técnico, Portugal
2016 - Atual Project in Biotechnology Biotecnologia (Mestrado integrado) Universidade de Lisboa Instituto Superior Técnico, Portugal
2014 - Atual Cell and Tissue Engineering Engenharia Biológica (Mestrado integrado) Universidade de Lisboa Instituto Superior Técnico, Portugal
2014 - Atual Cell and Tissue Engineering Biotecnologia (Mestrado integrado) Universidade de Lisboa Instituto Superior Técnico, Portugal
2014 - Atual Stem Cell Bioengineering Engenharia Biológica (Mestrado integrado) Universidade de Lisboa Instituto Superior Técnico, Portugal
2014 - Atual Stem Cell Bioengineering Biotecnologia (Mestrado integrado) Universidade de Lisboa Instituto Superior Técnico, Portugal
2014 - 2015 Biomedical Materials and Nanotechnology Bioengenharia e Nanossistemas (Mestrado) Universidade de Lisboa Instituto Superior Técnico, Portugal

Membro de comissão

Descrição da atividade
Tipo de participação 		Instituição / Organização
2023/01 - Atual Coordinator of the Master Degree in Bioengineering: Regenerative and Precision Medicine
Coordenador
 Universidade de Lisboa Instituto Superior Técnico, Portugal
2019 - Atual Scientific committee of the Masters in Bioengineering and Nanosystems
Membro
 Universidade de Lisboa Instituto Superior Técnico, Portugal
Distinções

Outra distinção

2016 Young Investigator Award
2011 Best Poster Presentation Award, MicroBiotec’11
2009 Travel Grant Award
2009 Crioestaminal Young Investigator Award
2008 Travel Grant Award
2008 Malcolm Lilly Award