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I am a Microbiologist with an MSc in Molecular Biology and Genetics from the Faculdade de Ciências Universidade de Lisboa (2008). As an undergraduate I conducted my research work at Instituto Nacional de Saúde Dr. Ricardo Jorge (Portugal) with Dra. Mafalda Bourbon, and at MRC-CSC Imperial College London (UK) with Prof. Anne Soutar to study of Familial Hypercholesterolaemia and perform in vitro cell biology and biochemical studies for characterizing patient mutations. In 2008 I was selected for the prestigious internship program InovContacto, run by the Portuguese Government to work as an R&D scientist in a biotech company in Denmark. In 2009 I was awarded a competitive individual fellowship from FCT and obtained my PhD degree at the University of Copenhagen (Denmark) in 2014, under the supervision of Prof. Michael Lisby. During my PhD studies I started working in the field of genomic instability studying the effect of SUMOylation, a post-translational modification, in the spatiotemporal regulation of DNA double-strand break (DSB) repair and telomere maintenance. To further my research in the genomic instability field, I moved to CABIMER in Seville, to join Prof. Andrés Aguilera for my postdoc and work on the role of R-loops and transcription-replication conflicts in genomic instability and their implication in DNA damage response. As a postdoc I led two main projects and participated in several others, implemented a new line of research in the Aguilera lab and created new tools to allow sophisticated cellular and molecular biology studies at specific DSB sites. During this period, I continued to produce high quality results published in several articles and Methods paper. In 2022 I returned to Portugal, joining Dr. Helder Maiato’s lab at i3S/University of Porto, a leading scientist in the field of cell division, where I continue to develop my research in the molecular mechanisms associated with chromosome instability and cancer, with a particular focus on breast cancer and translational research. Apart from a strong publication record, I have considerable teaching and supervision experience and I have now secured competitive national and international funding, currently leading or co-leading projects for FCT, Fundacion la Caixa and WorldWide Cancer Research.
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Identificação

Identificação pessoal

Nome completo
Sónia Cristina Pinela da Silva

Identificadores de autor

Ciência ID
9316-A5D3-EE72
ORCID iD
0000-0003-3700-3072
Google Scholar ID
https://scholar.google.com/citations?hl=en&user=Fn2tlGIAAAAJ
Researcher Id
F-2447-2016

Websites

Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2022/01/16 - Atual Pós-doutorado (Investigação) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2016/01 - 2021/11/30 Pós-doutorado (Investigação) Fundación de Investigación de la Universidad de Sevilla, Espanha
Centro Andaluz de Biología Molecular y Medicina Regenerativa, Espanha
(...)
2014/02/01 - 2015/05/31 Investigador (Investigação) Københavns Universitet Biologisk Institut, Dinamarca
2006/11 - 2007/08 Estagiário de Investigação (Investigação) Instituto do Emprego e Formação Profissional, Portugal
Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal
2006/01 - 2006/10 Estagiário de Investigação (Investigação) Imperial College Faculty of Medicine - Hammersmith Campus, Reino Unido

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2019 - 2020 Assistente (Docente Universitário) Universidad de Sevilla Departamento de Genética, Espanha

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2008/06 - 2009/02 Estágio INOV Contacto AICEP - Agência para o Investimento e Comércio Externo de Portugal, Portugal
Fluxome Sciences SA, Dinamarca
Produções

Publicações

Artigo em boletim informativo
  1. Rocha, Teresa; Alves, Ana Catarina; Medeiros, Ana; Francisco, Vânia; Silva, Sónia; Guiomar, Sofia; Paixão, Eleanora; et al. "Perfil de risco cardiovascular de estudantes do ensino secundário", Boletim Epidemiológico Observações, 2012, http://repositorio.insa.pt/bitstream/10400.18/878/5/Observa%C3%A7%C3%B5es%20Vol%201%20N%2012012.pdf.
Artigo em revista
  1. Maiato, Helder; Silva, Sónia. "Double-checking chromosome segregation". Journal of Cell Biology 222 5 (2023): http://dx.doi.org/10.1083/jcb.202301106.
    Publicado • 10.1083/jcb.202301106
  2. Esther Marchena-Cruz; Lola P. Camino; Jay Bhandari; Sónia Silva; José Javier Marqueta-Gracia; Shahad A. Amdeen; Cristina Guillén-Mendoza; et al. "DDX47, MeCP2, and other functionally heterogeneous factors protect cells from harmful R loops". Cell Reports 42 3 (2023): 112148-112148. http://dx.doi.org/10.1016/j.celrep.2023.112148.
    10.1016/j.celrep.2023.112148
  3. Sonia Jimeno; Rosario Prados-Carvajal; María Jesús Fernández-Ávila; Sonia Silva; Domenico Alessandro Silvestris; Martín Endara-Coll; Guillermo Rodríguez-Real; et al. "ADAR-mediated RNA editing of DNA:RNA hybrids is required for DNA double strand break repair". Nature Communications (2021): https://doi.org/10.1038/s41467-021-25790-2.
    10.1038/s41467-021-25790-2
  4. Gaetana, Sessa; Gómez-González, Belén ; Silva, Sónia; Pérez-Calero, Carmen ; Beaurepere, Romane; Barroso, Sonia ; Martineau, Sylvain; et al. Autor correspondente: Carreira, Aura. "BRCA2 promotes DNA-RNA hybrid resolution by DDX5 helicase at DNA breaks to facilitate their repair.". The EMBO journal 40 7 (2021): e106018. https://www.embopress.org/doi/abs/10.15252/embj.2020106018.
    Publicado • 10.15252/embj.2020106018
  5. Silva S; Camino LP; Aguilera A. "Human mitochondrial degradosome prevents harmful mitochondrial R loops and mitochondrial genome instability.". Proceedings of the National Academy of Sciences of the United States of America (2018): http://europepmc.org/abstract/med/30301808.
    10.1073/pnas.1807258115
  6. Juan Lafuente-Barquero; Francesca Storici; Sarah Luke-Glaser; Marco Graf; Sonia Silva; Belén Gómez-González; Arianna Lockhart; et al. "The Smc5/6 complex regulates the yeast Mph1 helicase at RNA-DNA hybrid-mediated DNA damage". PLOS Genetics 13 12 (2017): e1007136-e1007136. https://doi.org/10.1371/journal.pgen.1007136.
    10.1371/journal.pgen.1007136
  7. Churikov, D.; Charifi, F.; Eckert-Boulet, N.; Silva, S.; Simon, M.-N.; Lisby, M.; Géli, V.; Silva, Sónia. "SUMO-Dependent Relocalization of Eroded Telomeres to Nuclear Pore Complexes Controls Telomere Recombination". Cell Reports 15 6 (2016): 1242-1253. http://www.scopus.com/inward/record.url?eid=2-s2.0-84964650731&partnerID=MN8TOARS.
    10.1016/j.celrep.2016.04.008
  8. Silva, S.; Altmannova, V.; Eckert-Boulet, N.; Kolesar, P.; Gallina, I.; Hang, L.; Chung, I.; et al. "SUMOylation of Rad52-Rad59 synergistically change the outcome of mitotic recombination". DNA Repair 42 (2016): 11-25. http://www.scopus.com/inward/record.url?eid=2-s2.0-84964433786&partnerID=MN8TOARS.
    10.1016/j.dnarep.2016.04.001
  9. Kolesar, P.; Altmannova, V.; Silva, S.; Lisby, M.; Krejci, L.. "Pro-recombination Role of Srs2 Protein Requires SUMO (Small Ubiquitin-like Modifier) but Is Independent of PCNA (Proliferating Cell Nuclear Antigen) Interaction". J Biol Chem 291 14 (2016): 7594-607.
    10.1074/jbc.M115.685891
  10. Silva, Sonia; Altmannova, Veronika; Luke-Glaser, Sarah; Henriksen, Peter; Gallina, Irene; Yang, Xuejiao; Choudhary, Chunaram; et al. "Mte1 interacts with Mph1 and promotes crossover recombination and telomere maintenance.". Genes & development 30 6 (2016): 700-17. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=MEDLINE&KeyUT=MEDLINE:26966248&KeyUID=MEDLINE:26966248.
    10.1101/gad.276204.115
  11. Gallina, Irene; Colding, Camilla; Henriksen, Peter; Beli, Petra; Nakamura, Kyosuke; Offman, Judith; Mathiasen, David P.; et al. "Cmr1/WDR76 defines a nuclear genotoxic stress body linking genome integrity and protein quality control". Nature Communications 6 (2015): http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000352720000023&KeyUID=WOS:000352720000023.
    10.1038/ncomms7533
  12. Gallina, Irene; Colding, Camilla S.; Henriksen, Peter; Beli, Petra; Nakamura, Kyosuke; Offman, Judith; Mathiasen, David P.; et al. "Regulation of homologous recombination". Yeast 32 (2015): S32-S32. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000361466200009&KeyUID=WOS:000361466200009.
  13. Rocha, Teresa; Rocha, Evangelista; Alves, Ana Catarina; Medeiros, Ana Margarida; Francisco, Vania; Silva, Sonia; Gaspar, Isabel Mendes; Rato, Quiteria; Bourbon, Mafalda. "Cardiovascular risk profile of high school students: A cross-sectional study". Revista Portuguesa De Cardiologia 33 9 (2014): 525-534. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000343196100005&KeyUID=WOS:000343196100005.
    10.1016/j.repc.2014.01.024
  14. Silva, S.; Alves, A. C.; Patel, D.; Malho, R.; Soutar, A. K.; Bourbon, M.. "In vitro functional characterization of missense mutations in the LDLR gene". Atherosclerosis 225 1 (2012): 128-134. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000310354000019&KeyUID=WOS:000310354000019.
    10.1016/j.atherosclerosis.2012.08.017
  15. Medeiros, A. M.; Alves, A. C.; Francisco, V.; Silva, S.; Bourbon, M.; Portuguese FH Study. "Familial hypercholesterolaemia - an oportunity for preventive medicine". European Heart Journal 30 (2009): 374-374. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000208702603278&KeyUID=WOS:000208702603278.
  16. Bourbon, M.; Alves, A. C.; Medeiros, A. M.; Silva, S.; Soutar, A. K.; Investigators Portuguese FH Study. "Familial hypercholesterolaemia in Portugal". Atherosclerosis 196 2 (2008): 633-642. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000253743800018&KeyUID=WOS:000253743800018.
    10.1016/j.atherosclerosis.2007.07.019
  17. Silva, S.; Patel, D.; Bourbon, M.; Soutar, A. K.. "Functional characterization of point mutations in the LDLR gene found in Portuguese patients with clinical diagnosis of familial hypercholesterolaemia.". Atherosclerosis Supplements 8 1 (2007): 213-213. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000247869100858&KeyUID=WOS:000247869100858.
    10.1016/S1567-5688(07)71810-X
Capítulo de livro
  1. Silva, Sónia; Cristina Guillén-Mendoza; Andrés Aguilera. Autor correspondente: Andrés Aguilera. "RNase H1 Hybrid-Binding Domain-Based Tools for Cellular Biology Studies of DNA:RNA Hybrids in Mammalian Cells". 115-125. Springer {US, 2022.
    10.1007/978-1-0716-2477-7_8
  2. Silva, S.; Gallina, I.; Eckert-Boulet, N.; Lisby, M.. "Live cell microscopy of DNA damage response in saccharomyces cerevisiae". 2012.
    10.1007/978-1-61779-998-3-30