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Patrícia Sofia Menalha Amado graduated from the University of Algarve's Faculty of Science and Technology with a Master in Pharmaceutical Sciences (MICF) in 2015. She is currently a researcher at Algarve Centre of Marine Sciences (CCMAR), and she is finishing her PhD degree in Chemistry (specialty in Organic Chemistry), under the supervision of Prof. Maria de Lurdes Cristiano (University of Algarve) and Prof. Paul O'Neill (University of Liverpool). She has 10 peer-reviewed publications in journals such as the Journal of Organic Chemistry, ACS Omega, Journal of Physical Chemistry Letters, Medicinal Research Reviews, Molecules, ChemPlusChem, and The Journal of Physical Chemistry A. She participated in 10 international (3 poster presentations) and 5 national (3 oral and 4 poster presentations) conferences/symposiums/seminars/summer schools. She also co-supervised one project for the course of Biochemistry. In 2021, she received a prize (as first classified in the R&D category) in the contest "Ideias em Caixa 2020", along with two colleagues (Dr. Joana Leal and Prof. Maria Lurdes Cristiano). She also won the best poster prize at Conference ESOR2021, in September 2021. During her course at MICF, she received three awards as the year's best student. Her main fields are Synthetic and Organic Chemistry, with an emphasis on Medicinal Chemistry, her research interests include the development of novel catalysts for the synthesis of cyclic endoperoxides, the discovery of novel molecules for drug design, focusing on human infectious diseases such as Leishmaniasis and Tuberculosis, and the aquaculture parasitic disease Amyloodiniosis. Her laboratory skills involve detailed planning of new routes of organic reactions to synthesize novel compounds, from setting reactions up to their follow-up, followed by the procedures required for isolation and complete characterization of the nature and purity of synthesized products (1D/2D NMR, MS, IR). Computer skills: Microsoft Office (advanced in Word, Excel, and PowerPoint); IBM SPSS Statistics, ChemDraw, MestreNova, StarDrop, PyMol, GOLD suite, Spartan, Weka. Programming Languages: R and Python. Personal skills: resilient, responsible, proactive, and teamwork. Keywords: 1,2,4,5-tetraoxanes, 1,2,4-trioxanes, malaria, leishmaniasis, amyloodiniosis, tuberculosis.
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Identificação

Identificação pessoal

Nome completo
Patrícia Sofia Menalha Amado

Nomes de citação

  • Amado, Patrícia S. M.

Identificadores de autor

Ciência ID
8617-A360-B70A
ORCID iD
0000-0002-7307-9210
Scopus Author Id
57214102194

Websites

Domínios de atuação

  • Ciências Exatas - Química - Química Orgânica

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Espanhol; Castelhano Utilizador elementar (A1) Utilizador independente (B1) Utilizador elementar (A1) Utilizador elementar (A1)
Alemão Utilizador elementar (A1) Utilizador elementar (A1) Utilizador elementar (A1) Utilizador elementar (A1)
Chinês Utilizador elementar (A1) Utilizador elementar (A1) Utilizador elementar (A1) Utilizador elementar (A1)
Português (Idioma materno)
Formação
Grau Classificação
2022/07/03 - 2022/09/08
Concluído
 High-throughput and Ensemble-based Screening for Drug Discovery Workshop - 8 weeks (online) (Outros)
Bioinformatics Workshop Fiesta 2020/22, Singapura
2018/01/02 - 2022/02/28
Em curso
 Chemistry (Doutoramento)
Especialização em Organic Chemistry
Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
"PhD-Working programme: A Chemical Proteomics Approach to Defining the Mechanism of Artemisinin Action and Resistance in PfK13 Resistant parasites" (TESE/DISSERTAÇÃO)
2021/12/08 - 2021/12/11
Concluído
 4 Day Online Workshop on Introduction to Artificial Intelligence in Drug Discovery (Outros)
BDG Lifesciences, Índia
2021/12/04 - 2021/12/07
Concluído
 4 Day Online Workshop in Machine Learning in Chemoinformatics & Drug Discovery (Outros)
BDG Lifesciences, Índia
2021/03/01 - 2021/07/12
Concluído
 Python - Intermediate (Outros)
CINEL - Centro de Formação Profissional da Indústria Electrónica, Energia, Telecomunicações e Tecnologias da Informação, Portugal
 16
2021/04 - 2021/04
Concluído
 Smarter experimentation for scientists and engineers: online training programme on design of experiments (Outros)
JMP Group Inc, Estados Unidos
2020/11/01 - 2021/02/23
Concluído
 Python - Beginner (Outros)
CINEL - Centro de Formação Profissional da Indústria Electrónica, Energia, Telecomunicações e Tecnologias da Informação, Portugal
 19
2019/10 - 2019/12
Concluído
 Advanced Spectroscopic Elucidation for Organic Chemists (Outros)
University of Liverpool Department of Chemistry, Reino Unido
 18
2015
Concluído
 Integrated Master in Pharmaceutical Sciences (MICF) (Mestrado integrado)
Especialização em https://sapientia.ualg.pt/handle/10400.1/8128
Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
"Metodologias de síntese de tetraoxanos com potencial utilização em química medicinal " (TESE/DISSERTAÇÃO)
 17.21
Percurso profissional

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2022/05/01 - Atual Researcher. Project: MAR-01.03.01-FEAMP-0049 - DEPURATOX - Decontamination of bivalve molluscs, contaminated with marine biotoxins, during the purification process. Centro de Ciências do Mar, Portugal
2018/01/02 - Atual PhD Student in Chemistry. Thesis: "PhD-Working programme: A Chemical Proteomics Approach to Defining the Mechanism of Artemisinin Action and Resistance in PfK13 Resistant parasites" Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
University of Liverpool Department of Chemistry, Reino Unido
2016/03/29 - 2017/12/12 Technical Director Pharmacist Farmácia Brito, Portugal
2015/11/09 - 2016/03/28 Pharmacist Farmácia Brito, Portugal
2015/03/30 - 2015/08/28 Intern Pharmacist Farmácia Pacheco, Portugal
2015/03/02 - 2015/03/27 Intern. Learning the standards of good laboratory practices, quality control, chromatography techniques (HPLC, GC), production at an industrial level. Sofarimex - Indústria Química e Farmacêutica, S.A., Portugal
2014/09/15 - 2015/02/28 Research Volunteer. Development and synthesis of new tetraoxanes with antileishmania activity Centro de Ciências do Mar, Portugal
2014/06/30 - 2014/08/01 Exchange Student. Development and synthesis of new compounds with inhibitor capacity for the HIV integrase University of Sunderland, Reino Unido
2013/03/04 - 2013/06/28 Research Volunteer. Development and synthesis of new quinolones with antimalaric activity Centro de Ciências do Mar, Portugal
Projetos

Bolsa

Designação Financiadores
2018/01/02 - 2021/12/31 Chemical Proteomics Approach to Defining the Mechanism ofArtemisinin Action and Resistance in PfK13 Resistance
SFRH/BD/130407/2017
Bolseiro de Doutoramento
Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal

University of Liverpool Department of Chemistry, Reino Unido
Em curso
Produções

Publicações

Artigo em revista
  1. Patrícia S. M. Amado; Christopher Woodley; Maria L. S. Cristiano; Paul M. O’Neill. "Recent Advances of DprE1 Inhibitors against Mycobacterium tuberculosis: Computational Analysis of Physicochemical and ADMET Properties". ACS Omega (2022): https://doi.org/10.1021/acsomega.2c05307.
    10.1021/acsomega.2c05307
  2. Patrícia S. M. Amado; Inês C. C. Costa; José A. Paixão; Ricardo F. Mendes; Sofia Cortes; Maria L. S. Cristiano. "Synthesis, Structure and Antileishmanial Evaluation of Endoperoxide-Pyrazole Hybrids". Molecules (2022): https://doi.org/10.3390/molecules27175401.
    10.3390/molecules27175401
  3. Patricia Sofia Menalha Amado. "Unravelling the Structure of Peroxides with Antiparasitic Activity: The Relative Impact of a Trioxolane or a Tetraoxane Pharmacophore on the Overall Molecular Structure". ChemPlusChem (2022): http://dx.doi.org/10.1002/cplu.202200207.
    10.1002/cplu.202200207
  4. Andreia Mendes; Ana Armada; Lília I. L. Cabral; Patricia Sofia Menalha Amado; Lenea Campino; Maria Lurdes Santos Cristiano; Cortes S.. "1,2,4-Trioxolane and 1,2,4,5-Tetraoxane Endoperoxides against Old-World Leishmania Parasites: In Vitro Activity and Mode of Action". Pharmaceuticals (2022): https://www.mdpi.com/1424-8247/15/4/446.
    10.3390/ph15040446
  5. Woodley, Christopher M.; Amado, Patrícia S. M.; Cristiano, Maria L. S.; O'Neill, Paul M.. "Artemisinin inspired synthetic endoperoxide drug candidates: Design, synthesis, and mechanism of action studies". Medicinal Research Reviews (2021): http://dx.doi.org/10.1002/med.21849.
    10.1002/med.21849
  6. Amado, Patrícia S. M.; Frija, Luís M. T.; Coelho, Jaime A. S.; O’Neill, Paul M.; Cristiano, Maria L. S.. "Synthesis of Non-symmetrical Dispiro-1,2,4,5-Tetraoxanes and Dispiro-1,2,4-Trioxanes Catalyzed by Silica Sulfuric Acid". The Journal of Organic Chemistry 86 15 (2021): 10608-10620. http://dx.doi.org/10.1021/acs.joc.1c01258.
    Publicado • 10.1021/acs.joc.1c01258
  7. Joana F. Leal; Bruno Guerreiro; Patrícia S. M. Amado; André L. Fernandes; Luísa Barreira; José A. Paixão; Maria L. S. Cristiano. "On the Development of Selective Chelators for Cadmium: Synthesis, Structure and Chelating Properties of 3-((5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl)amino)benzo[d]isothiazole 1,1-dioxide, a Novel Thiadiazolyl Saccharinate". Molecules 26 6 (2021): 1501-1501. https://doi.org/10.3390/molecules26061501.
    10.3390/molecules26061501
  8. Nunes, Cláudio M.; Pereira, Nelson A. M.; Reva, Igor; Amado, Patrícia S. M.; Cristiano, Maria L. S.; Fausto, Rui. "Bond-Breaking/Bond-Forming Reactions by Vibrational Excitation: Infrared-Induced Bidirectional Tautomerization of Matrix-Isolated Thiotropolone". The Journal of Physical Chemistry Letters 11 19 (2020): 8034-8039. http://dx.doi.org/10.1021/acs.jpclett.0c02272.
    10.1021/acs.jpclett.0c02272
  9. Brás, Elisa M.; Cabral, Lília I. L.; Amado, Patrícia S. M.; Abe, Manabu; Fausto, Rui; Cristiano, Maria L. S.. "Photoinduced Reactivity in a Dispiro-1,2,4-trioxolane: Adamantane Ring Expansion and First Direct Observation of the Long-Lived Triplet Diradical Intermediates". The Journal of Physical Chemistry A 124 21 (2020): 4202-4210. http://dx.doi.org/10.1021/acs.jpca.0c01974.
    10.1021/acs.jpca.0c01974
  10. Lília I. L. Cabral; Sébastien Pomel; Sandrine Cojean; Patrícia S. M. Amado; Philippe M. Loiseau; Maria L. S. Cristiano. "Synthesis and Antileishmanial Activity of 1,2,4,5-Tetraoxanes against Leishmania donovani". Molecules 25 3 (2020): 465-465. https://doi.org/10.3390/molecules25030465.
    10.3390/molecules25030465
Capítulo de livro
  1. Amado, Patrícia S. M.; Luís Frija; O'Neill, Paul M.; Cristiano, Maria Lurdes Santos. "Synthesis of non-symmetrical 1,2,4,5-tetraoxanes: Past and current routes". In Synthesis and Applications in Chemistry and Materials. World Scientific, 2023.
    Em revisão
Poster em conferência
  1. Amado, Patrícia S. M.. "Comparison of Structural and Energetic Properties Between Trioxolane and Tetraoxane Analogues with Established Antiparasitic Activity". Trabalho apresentado em 8th EuChemS Chemistry Congress, 2022.
  2. Amado, Patrícia. "An Endoperoxide-Based Hybrid Approach against Mycobacterium tuberculosis". Trabalho apresentado em Encontro Anual de Doutorandos Da Universidade do Algarve, 2021.
  3. Amado, Patrícia; Luís M. T. Frija; Jaime A. S. Coelho; Paul O'Neill; Cristiano, Maria Lurdes Santos. "Synthesis of Non-symmetrical Dispiro-1,2,4,5-Tetraoxanes and Dispiro-1,2,4-Trioxanes Catalyzed by Silica Sulfuric Acid". Trabalho apresentado em 18th European Symposium on Organic Reactivity (ESOR2021), 2021.
  4. Amado, Patrícia; Luís Frija; Jaime A. S. Coelho; Paul O'Neill; Professsora Doutora Maria de Lurdes Cristiano. "A facile, efficient, and reusable silica sulfuric acid (ssa) catalysed synthesis of non-symmetrical 1,2,4,5-tetraoxanes and 1,2,4-trioxanes". Trabalho apresentado em 7PYCHEM (7th Portuguese Young Chemists Meeting), 2021.
  5. Amado, Patrícia; Elisa M. Brás; José A. Paixão; Rui Fausto; Maria L. S. Cristiano. "Unraveling the structure of peroxides with antiparasitic activity; relative impact of a trioxolane or a tetraoxane pharmacophore on the overall molecular structure". Trabalho apresentado em First National Crystallographic Meeting, 2019.
  6. Amado, Patrícia; Lília I. L. Cabral; Sébastien Pomel; Sandrine Cojean; Philippe M. Loiseau; Maria L. S. Cristiano. "Synthesis and in vitro antileishmanial activity of selected tetraoxanes against Leishmania donovani". Trabalho apresentado em 6th portuguese young chemists meeting, 2018.
    10.3390/molecules25030465
Tese / Dissertação
  1. Amado, Patrícia. "Metodologias de síntese de tetraoxanos com potencial utilização em química medicinal". Mestrado, Universidade do Algarve, 2015. https://sapientia.ualg.pt/handle/10400.1/8128.
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2022/04/22 An Endoperoxide Based Hybrid Approach against Mycobacterium tuberculosis 14th National Organic Chemistry Meeting (14ENQO) and 7th National Medicinal Chemistry Meeting (7ENQT)
Portuguese Chemical Society (SPQ) (Lisbon, Portugal)
2021/10/29 An Endoperoxide-Based Hybrid Approach against Mycobacterium tuberculosis Encontro Anual de Doutorandos Da Universidade do Algarve
(Loulé)
2020/11/19 Finalist at "1st NATIONAL RETROSYNTHESIS COMPETITION 2020" Oral presentation done at the 7th Portuguese Young Chemists Meeting, between May 19th to 21st - 2021
(Portugal)

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2020/11 - 2021/09 Synthesis of endoperoxide-pyrazole hybrids with potential activity against Leishmania donovani
Coorientador
 Bioquímica (Licenciatura/Bacharelato)
Universidade do Algarve, Portugal

Participação em evento

Descrição da atividade
Tipo de evento 		Nome do evento
Instituição / Organização
2022/08/28 - 2022/09/01 8th EuChemS Chemistry Congress - Lisbon
Congresso
EuChemS, Bélgica

Sociedade Portuguesa de Química, Portugal
2022/04/20 - 2022/04/22 14th National Organic Chemistry Meeting (14ENQO) and 7th National Medicinal Chemistry Meeting (7ENQT)
Encontro
2021/10/12 - 2021/10/13 2nd Symeres Precision Chemistry Conference on Tools for Molecular Recognition and Diagnostics
Conferência
 2nd Symeres Precision Chemistry Conference on Tools for Molecular Recognition and Diagnostics
LD Organisation - Scientific Conference Producers, Bélgica
2021/09/21 - 2021/09/23 18th European Symposium on Organic Reactivity (ESOR2021)
Simpósio
 18th European Symposium on Organic Reactivity (ESOR2021)
2021/09/13 - 2021/09/17 EUROPIN Summer School on Drug: The summer school especially focuses on students and professionals who have a clear interest in learning the basics as well as latest developments in Pharmacoinformatics. The program provides an overview on main approaches and techniques used in computational drug design, ranging from protein modeling, docking, pharmacophore based screening, up to machine learning, data science, and workflows.
Seminário
 EUROPIN Summer School on Drug Design
2021/08/29 - 2021/09/02 XXVI EFMC International Symposium on Medicinal Chemistry (EFMC-ISMC 2021)
Simpósio
 XXVI EFMC International Symposium on Medicinal Chemistry (EFMC-ISMC 2021)
LD Organisation - Scientific Conference Producers, Bélgica
2021/05/19 - 2021/05/21 Conference 7th portuguese young chemists meeting
Encontro
 Conference 7th portuguese young chemists meeting
Sociedade Portuguesa de Química, Portugal
2021/05/04 - 2021/05/06 Launching Drug Discovery from Huge Chemical Space
Simpósio
 Online Symposium on Novel Computational Approaches for Hit Generation.
LD Organisation - Scientific Conference Producers, Bélgica
2019/11/05 - 2019/11/06 Conference Drug Discovery 2019: Looking Back To The Future, Liverpool, UK
Conferência
 https://elrig.org/portfolio/2019-drug-discovery/
2019/03/18 - 2019/03/20 Participation on "From Molecure to Medicine" Training School
Outro
 https://epichembio.eu/training-school-from-molecule-to-medicine-ljubljana/
Univerza v Ljubljani Fakulteta za farmacijo, Eslovénia
2018/07/01 - 2018/07/06 Conference ICPOC - 24th International Conference on Physical Organic Chemistry
Congresso
 https://icpoc24.ualg.pt/
Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
2018/05/15 - 2018/05/18 Conference 6th portuguese young chemists meeting
Conferência
 http://6pychem.eventos.chemistry.pt/
Distinções

Prémio

2021 Poster Prize Winner: "Synthesis of Non-symmetrical Dispiro-1,2,4,5-Tetraoxanes and Dispiro-1,2,4-Trioxanes Catalyzed by Silica Sulfuric Acid"
2021 1st classified in the R&D category, in the contest "Ideias em Caixa"
Universidade do Algarve, Portugal

Caixa Geral de Depositos, Portugal

Comissão de Coordenação e Desenvolvimento Regional do Algarve, Portugal
2016 Winner of Prize: "Prémio Sociedade Farmacêutica Lusitana"
Ordem dos Farmaceuticos, Portugal

Outra distinção

2018 PhD Scholarship
Fundação para a Ciência e a Tecnologia, Portugal
2013 Award: "ALUNO DE EXCELÊNCIA FCT 2013, categoria II"
Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
2012 Award: "ALUNO DE EXCELÊNCIA FCT 2012, categoria I"
Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal