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I am currently a postdoctoral fellow in the group of Helder Maiato at the Instituto de Investigação e Inovação em Saúde (i3S). I have strong expertise in cell division, having studied both mitosis during my PhD in the group of Stephen Royle, and mammalian meiosis in the group of Melina Schuh. Currently, I am studying fundamental mechanisms of cell division in mitosis and meiosis using rapid protein inactivation techniques. At i3S, I have set up the mammalian oocyte model system, bringing new expertise and generating new collaborations within the institute and internationally. I aim to transition to an independent research career within the next few years and establish my position in the field of cell division. To do so, I am leading my currently project semi-independently, have opened a new line of research in my host laboratory, and have already attracted competitive funding, such as a Marie Sklodowska-Curie Fellowship and a NanoPrime grant from the Engineering and Physical Sciences Research Council (UK). Overall, I have published 7 papers in high-impact journals, which have had a strong influence on the field. I have mentored and co-supervised 2 PhD students and 1 Master student, and am currently co-supervising 1 PhD student. I also participate in science communication and dissemination by being a contributor to PreLights (Company of Biologists), organising regional science meetings in Cell Biology, and a strong online presence (@SciencyCheese). I have also been consistently involved in policy-making as illustrated by taking on roles such as Postgraduate Physiology Society President, University Senate Representative, and more recently Representative of Foreign Researchers at i3S.
Identificação

Identificação pessoal

Nome completo
Liam Cheeseman

Nomes de citação

  • Cheeseman, Liam

Identificadores de autor

Ciência ID
751A-E3EF-AE08
ORCID iD
0000-0003-4497-140X
Google Scholar ID
https://scholar.google.com/citations?user=TXRSIf0AAAAJ&hl=en

Moradas

  • i3S – Instituto de Investigação e Inovação em Saúde Da Universidade do Porto. Rua Alfredo Allen, 208, 4200-135, Porto, Porto, Portugal (Profissional)

Websites

Domínios de atuação

  • Ciências Naturais - Ciências Biológicas - Biologia Celular
  • Ciências Naturais - Ciências Biológicas - Biologia da Reprodução
  • Ciências Naturais - Ciências Biológicas - Biologia Celular

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês (Idioma materno)
Francês (Idioma materno)
Português Utilizador elementar (A1) Utilizador elementar (A1) Utilizador elementar (A1) Utilizador elementar (A1)
Formação
Grau Classificação
2014
Concluído
Wellcome Trust PhD in Biomedical Sciences - Cellular and molecular physiology (Doutoramento)
University of Liverpool, Reino Unido
"Rapid removal of TACC3–ch-TOG–clathrin from kinetochore fibres during mitosis" (TESE/DISSERTAÇÃO)
N/A
2010
Concluído
Cellular and molecular physiology (Mestrado)
University of Liverpool, Reino Unido
"N/A" (TESE/DISSERTAÇÃO)
Distinction (>70%)
2009
Concluído
Animal and vegetal physiology (Licenciatura)
Université Toulouse III Paul Sabatier, França
"N/A" (TESE/DISSERTAÇÃO)
15/20 (Ranked 1st)
2009
Concluído
Imperial College International Diploma - ERASMUS (Bacharelato)
Imperial College London, Reino Unido
"N/A" (TESE/DISSERTAÇÃO)
2.1 (Upper second class)
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento
Empregador
2016/10 - Atual Pós-doutorado (Investigação) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2014/01/06 - 2016/08/31 Pós-doutorado (Investigação) MRC Laboratory of Molecular Biology, Reino Unido
MRC Laboratory of Molecular Biology, Reino Unido
Projetos

Bolsa

Designação Financiadores
2019/09 - Atual Defining the architecture of chromosomes in human oocytes
RA4640
Investigador responsável
University of Nottingham, Reino Unido
Engineering and Physical Sciences Research Council
Em curso
2017/07 - 2019 Investigating how anaphase chromosomal motion is generated during mitosis and meiosis
746515
Bolseiro de Pós-Doutoramento
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
European Commission
Concluído
2009/09 - 2013/09 Identification and functional characterisation of microtubule cross-linkers during mitosis
089140/Z/09/Z
Bolseiro de Doutoramento
University of Liverpool Department of Cellular and Molecular Physiology, Reino Unido
Wellcome Trust
Concluído
Produções

Publicações

Artigo em boletim informativo
  1. Cheeseman, Liam. "chTOG is a conserved mitotic error correction factor", preLights - The Company of Biologists, 2020, https://doi.org/10.1242/prelights.24951.
    10.1242/prelights.24951
Artigo em revista
  1. Cheeseman, Liam. "Chromosomal Instability: stretching the role of checkpoint silencing". Current Biology (2021):
    No prelo • 10.1016/j.cub.2021.02.014
  2. Afonso, Olga; Castellani, Colleen M; Cheeseman, Liam P; Ferreira, Jorge G; Orr, Bernardo; Ferreira, Luisa T; Chambers, James J; et al. "Spatiotemporal control of mitotic exit during anaphase by an aurora B-Cdk1 crosstalk". eLife 8 (2019): http://dx.doi.org/10.7554/elife.47646.
    Publicado • 10.7554/elife.47646
  3. Cheeseman, Liam P.; Boulanger, Jérôme; Bond, Lisa M.; Schuh, Melina. "Two pathways regulate cortical granule translocation to prevent polyspermy in mouse oocytes". Nature Communications 7 1 (2016): http://dx.doi.org/10.1038/ncomms13726.
    Publicado • 10.1038/ncomms13726
  4. Sacco, Joseph J.; Kenyani, Jenna; Butt, Zohra; Carter, Rachel; Chew, Hui Yi; Cheeseman, Liam P.; Darling, Sarah; et al. "Loss of the deubiquitylase BAP1 alters class I histone deacetylase expression and sensitivity of mesothelioma cells to HDAC inhibitors". Oncotarget 6 15 (2015): http://dx.doi.org/10.18632/oncotarget.3765.
    Publicado • 10.18632/oncotarget.3765
  5. Cheeseman, L. P.; Harry, E. F.; McAinsh, A. D.; Prior, I. A.; Royle, S. J.. "Specific removal of TACC3-ch-TOG-clathrin at metaphase deregulates kinetochore fiber tension". Journal of Cell Science 126 9 (2013): 2102-2113. http://dx.doi.org/10.1242/jcs.124834.
    Publicado • 10.1242/jcs.124834
  6. Cheeseman, Liam P.; Booth, Daniel G.; Hood, Fiona E.; Prior, Ian A.; Royle, Stephen J.. "Aurora A kinase activity is required for localization of TACC3/ch-TOG/clathrin inter-microtubule bridges". Communicative & Integrative Biology 4 4 (2011): 409-412. http://dx.doi.org/10.4161/cib.15250.
    Publicado • 10.4161/cib.15250
Capítulo de livro
  1. Booth, Daniel G.; Cheeseman, Liam P.; Prior, Ian A.; Royle, Stephen J.. "Studying Kinetochore-Fiber Ultrastructure Using Correlative Light-Electron Microscopy". In Methods in Cell Biology, 327-342. Elsevier, 2013.
    Publicado • 10.1016/b978-0-12-407757-7.00020-7
Tese / Dissertação
  1. Cheeseman, Liam. "Rapid removal of TACC3–ch-TOG–clathrin from kinetochore fibres during mitosis". Doutoramento, University of Liverpool, 2013. http://livrepository.liverpool.ac.uk/id/eprint/14573.
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2013 Specific removal of TACC3-ch-TOG-clathrin at metaphase deregulates kinetochore fiber tension North England Cell Biology conference
(Reino Unido)
2013 Specific removal of TACC3-ch-TOG-clathrin at metaphase deregulates kinetochore fiber tension Liverpool Electron Microscopy symposium
(Reino Unido)
2011 Aurora A kinase activity is required for localization of TACC3/ch-TOG/clathrin inter-microtubule bridges Liverpool Cancer Research UK Annual Meeting
Cancer Research UK (Reino Unido)

Orientação

Título / Tema
Papel desempenhado
Curso (Tipo)
Instituição / Organização
2018/05/01 - 2018/08/01 CENP-E expression in C. elegans
Coorientador de Ana Isabel Coelho de Almeida
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2013/01/01 - 2013/09/30 The mesh is a network of microtubule connectors that stabilizes individual kinetochore fibers of the mitotic spindle
Coorientador
University of Liverpool Department of Cellular and Molecular Physiology, Reino Unido
2012/04/01 - 2012/07/01 Development of a method to swiftly remove and thereby inactivate microtubule associated proteins during mitosis
Coorientador
University of Liverpool Department of Cellular and Molecular Physiology, Reino Unido

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação)
Instituição / Organização
2012 - 2012 Liverpool Inter-University Postgraduate Symposium. Over 150 post-graduate students from the universities of Liverpool and Manchester took part in a day of oral and poster presentations to encourage data dissemination and foster collaborations. (2012 - 2012)
Simpósio (Presidente da Comissão Organizadora)
University of Liverpool Department of Cellular and Molecular Physiology, Reino Unido

Participação em evento

Descrição da atividade
Tipo de evento
Nome do evento
Instituição / Organização
2020/05 - Atual I perform viral RNA extraction from patient samples for COVID-19 diagnostic tests, as part of the i3S response to the global pandemic.
Outro
COVID-19 Taskforce
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2017 - Atual FELASA level C certification for work with laboratory animals. This is the equivalent of a personal animal license.
Outro
FELASA category C training course
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2018 - 2018 2018 American Society for Cell Biology Annual Meeting 2018 American Society for Cell Biology Annual Meeting
2017/04/19 - 2017/04/21 Introduction course to data analysis and image processing with MATLAB
Oficina (workshop)
Introduction to data analysis and image processing with MATLAB
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2017 - 2017 2017 American Society for Cell Biology Annual Meeting
Conferência
2017 American Society for Cell Biology Annual Meeting
2015 - 2015 2015 American Society for Cell Biology Annual Meeting - Poster presentation
Conferência
2015 American Society for Cell Biology Annual Meeting
2012 - 2012 2012 EMBO Microtubule meeting - Poster presentation
Conferência
2012 EMBO Microtubule meeting
2012 - 2012 2012 Liverpool Cancer Research UK annual meeting - Poster presentation
Conferência
2012 Liverpool Cancer Research UK annual meeting
2012 - 2012 2012 British Society for Cell Biology Annual meeting - Poster presentation
Conferência
2012 British Society for Cell Biology Annual meeting
2012 - 2012 2012 American Society for Cell Biology Annual Meeting - Poster presentation
Conferência
2012 American Society for Cell Biology Annual Meeting
2011 - 2011 2011 American Society for Cell Biology Annual Meeting - Poster presentation
Conferência
American Society for Cell Biology Annual Meeting
2011 - 2011 2011 North England Cell Biology conference - Poster presentation
Conferência
North England Cell Biology conference

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2012/01 - 2012/05 University of Liverpool, Bachelor of Science in Physiology, 2nd Year Physiology (Bachelor) University of Liverpool Faculty of Health and Life Sciences, Reino Unido
2011/01 - 2011/05 University of Liverpool, Bachelor of Science in Physiology, 2nd Year Physiology (Bachelor) University of Liverpool Faculty of Health and Life Sciences, Reino Unido

Entrevista (jornal / revista)

Descrição da atividade Jornal / Forum
2014 Journal of Cell Science Prize 2013 Journal of Cell Science

Entrevista / Programa (rádio / tv)

Programa Tema
2017/03/28 - Atual RTP1 news UK Science and Brexit

Membro de comissão

Descrição da atividade
Tipo de participação
Instituição / Organização
2018 - 2018 Representative of foreign researchers at i3S
Outro
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2012/01 - 2013/01 President of the Physiology Post-Graduate Society
Presidente / Vice-presidente
University of Liverpool Department of Cellular and Molecular Physiology, Reino Unido
2011 - 2013 Post-Graduate Senate representative of the Faculty of Health and Life Science University of Liverpool Faculty of Health and Life Sciences, Reino Unido
2011 - 2012 Treasurer of the Physiology Post-Graduate Society
Distinções

Prémio

2017 Maria Sklodowska-Curie Fellowship
European Commission, Bélgica
2009 Wellcome Trust Studentship
Wellcome Trust, Reino Unido

Outra distinção

2014 Journal of Cell Science Award 2013
2012 North England Cell Biology conference – 1st Prize for Best Poster
2012 British Young Cell Biologist of the Year
British Society for Cell Biology, Reino Unido
2011 Liverpool Cancer Research UK annual meeting – 1st Prize for Best Talk
Cancer Research UK, Reino Unido
2011 University of Liverpool Ede & Ravenscroft Award