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Tiago Miguel Guerra Miranda Bandeiras. Completed the Doutoramento in Bioquímica in 2005/03/29 by Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica and Licenciatura in Química Aplicada, Ramo Biotecnologia in 2000 by Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia. Is Merck Healthcare Lab Head in Instituto de Biologia Experimental e Tecnológica. Published 61 articles in journals. Has 1 book(s). Organized 6 event(s). Supervised 3 PhD thesis(es) e co-supervised 4. Supervised 4 MSc dissertation(s) e co-supervised 1. Has received 1 awards and/or honors. Participates and/or participated as Principal investigator in 3 project(s) and Researcher in 4 project(s). Works in the area(s) of Natural sciences with emphasis on Biological Sciences with emphasis on Biochemistry. In his curriculum Ciência Vitae the most frequent terms in the context of scientific, technological and artistic-cultural output are: Structural Biology; X-Ray Crystallography; Radical Oxygen Species; Cancer; Drug Discovery; ATPases; Helicases; Large Cellular Protein Complexes; Protein:Protein Interactions; Health Sciences - Microbiology and Infection; .
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Identificação

Identificação pessoal

Nome completo
Tiago Miguel Guerra Miranda Bandeiras

Nomes de citação

  • M. Bandeiras, Tiago

Identificadores de autor

Ciência ID
671D-024B-AE87
ORCID iD
0000-0001-6089-6089

Domínios de atuação

  • Ciências Naturais - Ciências Biológicas - Bioquímica

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Alemão Utilizador independente (B1) Utilizador independente (B1) Utilizador independente (B1) Utilizador independente (B1)
Formação
Grau Classificação
2005/03/29
Concluído
 Bioquímica (Doutoramento)
Especialização em Especialidade: Bioquímica
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
"Archaeal Respiratory Chains - Coupling the Sulfur to Oxygenic Metabolism" (TESE/DISSERTAÇÃO)
2000
Concluído
 Química Aplicada, Ramo Biotecnologia (Licenciatura)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
"NADH dehydrogenases from archaea" (TESE/DISSERTAÇÃO)
 15
Percurso profissional

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2016/01/01 - Atual Merck Healthcare Lab Head Instituto de Biologia Experimental e Tecnológica, Portugal
2013/03/01 - 2015/12/31 Senior Researcher & Project Manager in Structure-based Drug Design at IBET Instituto de Biologia Experimental e Tecnológica, Portugal
2008/03/01 - 2013/02/28 Auxiliary Researcher (Ciência 2007 Program) Instituto de Biologia Experimental e Tecnológica, Portugal
2005/03/01 - 2008/02/29 Post-Doc in preclinical projects for pharmaceutical companies such as Merck Serono and Bayer Schering Pharma - Structure-based drug design projects. Instituto de Biologia Experimental e Tecnológica, Portugal
2003/09/01 - 2005/09/01 Assistant and Auxiliary Professor - Bioenergetics and Enzymology Universidade Lusófona de Humanidades e Tecnologias, Portugal
2001/01/01 - 2005/03/29 PhD student in Biochemistry - Bioenergetics studies in Extremophiles Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
Projetos

Bolsa

Designação Financiadores
2016/06/01 - 2019/12/31 Structure and Function of a Dodecameric Molecular Machine: the human RuvBL1/RuvBL2 Complex and its Role in Disease
PTDC/BBB-BEP/1463/2014
Investigador responsável
Instituto de Biologia Experimental e Tecnológica, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2016/01/01 - 2019/12/31 Therapeutic Targets for Triple Negative Breast Cancer: Development of mono and bispecific antibodies against Notch1 ligands
PTDC/BBB-BMD/4497/2014
Investigador
Instituto de Biologia Experimental e Tecnológica, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2013/06/01 - 2015/11/30 Structural and functional insights into centriole biogenesis
PTDC/BBB-BEP/1724/2012
Investigador responsável
Instituto de Biologia Experimental e Tecnológica, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2012/01/01 - 2014/12/31 Development of function blocking antibodies using Phage Display Tecnhology: Inhibition of the Notch1 signaling pathway by function blocking anti-jagged 1 antibody
PTDC/SAU-ONC/121670/2010
Investigador
Instituto de Biologia Experimental e Tecnológica, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2011/09/01 - 2014/08/31 Response to oxidative and nitrosative stress by Entamoeba histolytica: searching for new virulence factors
info:eu-repo/grantAgreement/FCT/3599-PPCDT/111447/PT
Investigador
Universidade de Lisboa Faculdade de Farmácia, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2011/03/01 - 2014/08/31 Structural determinants of superoxide reduction - A detoxification system essential for life
PTDC/BIA-PRO/111940/2009
Investigador responsável
Instituto de Biologia Experimental e Tecnológica, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2008/06 - 2009/05 A structural genomics approach to membrane transport proteins from Archaea
PTDC/BIA-PRO/66833/2006
Investigador
Fundação para a Ciência e a Tecnologia

Projeto

Designação Financiadores
2016/07 - 2020/03 Alvos terapêuticos para o cancro da mama triplo negativo: Desenvolvimento de anticorpos mono e biespecíficos contra ligandos do Notch1
PTDC/BBB-BMD/4497/2014
 Fundação para a Ciência e a Tecnologia
Produções

Publicações

Artigo em revista
  1. Heinrich, Timo; Schwarz, Daniel; Petersson, Carl; Gunera, Jakub; Garg, Sakshi; Schneider, Richard; Keil, Marina; et al. "MoA Studies of the TEAD P-Site Binding Ligand MSC-4106 and Its Optimization to TEAD1-Selective Amide M3686". Journal of Medicinal Chemistry (2024): https://doi.org/10.1021/acs.jmedchem.4c01949.
    10.1021/acs.jmedchem.4c01949
  2. Abéza, Claire; Busse, Philipp; Paiva, Ana C.F.; Chagot, Marie-Eve; Schneider, Justine; Robert, Marie-Cécile; Vandermoere, Franck; et al. "The HSP90/R2TP Quaternary Chaperone Scaffolds Assembly of the TSC Complex". Journal of Molecular Biology 436 23 (2024): 168840. https://doi.org/10.1016/j.jmb.2024.168840.
    10.1016/j.jmb.2024.168840
  3. Bailey, Henry J.; Eisert, Jonathan; Kazi, Rubina; Gerhartz, Jan; Pienkowska, Dominika Ewa; Dressel, Ina; Vollrath, Joshua; et al. "An engineered cereblon optimized for high throughput screening and molecular glue discovery". Cell Chemical Biology (2024): https://doi.org/10.1016/j.chembiol.2024.11.002.
    10.1016/j.chembiol.2024.11.002
  4. Fernández-Quintero, Monica L.; Guarnera, Enrico; Musil, Djordje; Pekar, Lukas; Sellmann, Carolin; Freire, Filipe; Sousa, Raquel L.; et al. "On the humanization of VHHs: Prospective case studies, experimental and computational characterization of structural determinants for functionality". Protein Science 33 11 (2024): https://doi.org/10.1002/pro.5176.
    10.1002/pro.5176
  5. Pires, Carolina; Marques, Inês J.; Saramago, Ana; Moura, Margarida M.; Pojo, Marta; Cabrera, Rafael; Santos, Catarina; et al. "Identification of novel candidate predisposing genes in familial nonmedullary thyroid carcinoma implicating DNA damage repair pathways". International Journal of Cancer 156 1 (2024): 130-144. https://doi.org/10.1002/ijc.35159.
    10.1002/ijc.35159
  6. Hugo Gizardin-Fredon; Paulo E. Santo; Marie-Eve Chagot; Bruno Charpentier; Tiago M. Bandeiras; Xavier Manival; Oscar Hernandez-Alba; Sarah Cianférani. "Denaturing mass photometry for rapid optimization of chemical protein-protein cross-linking reactions". Nature Communications (2024): https://doi.org/10.1038/s41467-024-47732-4.
    10.1038/s41467-024-47732-4
  7. Inês C. Ferreira; Estefania Torrejón; Bernardo Abecasis; Bruno M. Alexandre; Ricardo A. Gomes; Chris Verslype; Jos van Pelt; et al. "Aldehyde Dehydrogenase 2 (ALDH2): A novel sorafenib target in hepatocellular carcinoma unraveled by the proteome-wide cellular thermal shift assay". SLAS Discovery (2024): https://doi.org/10.1016/j.slasd.2024.100154.
    10.1016/j.slasd.2024.100154
  8. Pires, Carolina; Marques, Inês J.; Valério, Mariana; Saramago, Ana; Santo, Paulo E.; Santos, Sandra; Silva, Margarida; et al. "CHEK2 germline variants identified in familial non-medullary thyroid cancer lead to impaired protein structure and function". Journal of Biological Chemistry (2024): 105767. http://dx.doi.org/10.1016/j.jbc.2024.105767.
    10.1016/j.jbc.2024.105767
  9. Grädler U; Schwarz D; Wegener A; Eichhorn T; Bandeiras TM; Freitas MC; Lammens A; et al. "Biophysical and structural characterization of the impacts of MET phosphorylation on tepotinib binding.". The Journal of biological chemistry (2023): https://doi.org/10.1016/j.jbc.2023.105328.
    10.1016/j.jbc.2023.105328
  10. Ana C. F. Paiva; Ana Rita Lemos; Philipp Busse; Martins MT; Diana O. Silva; Micael Freitas; Sandra Isabel Pereira dos Santos; et al. "Extract2Chip-Bypassing Protein Purification in Drug Discovery Using Surface Plasmon Resonance.". Biosensors (2023): https://europepmc.org/articles/PMC10605449.
    10.3390/bios13100913
  11. Tiago M. Bandeiras; Dos Santos Morais R; Santo PE; Marie Ley; Schelcher C; Abel Y; Plassart L; et al. "Deciphering cellular and molecular determinants of human DPCD protein in complex with RUVBL1/RUVBL2 AAA-ATPases.". Journal of molecular biology (2022): https://doi.org/10.1016/j.jmb.2022.167760.
    10.1016/j.jmb.2022.167760
  12. Timo Heinrich; Peterson C; Schneider R; Garg S; Schwarz D; Gunera J; Seshire A; et al. "Optimization of TEAD P-Site Binding Fragment Hit into In Vivo Active Lead MSC-4106.". Journal of medicinal chemistry (2022): https://doi.org/10.1021/acs.jmedchem.2c00403.
    10.1021/acs.jmedchem.2c00403
  13. Silva, Gabriela; Sales-Dias, Joana; Casal, Diogo; Alves, Sara; Domenici, Giacomo; Barreto, Clara; Matos, Carolina; et al. "Development of Dl1.72, a Novel Anti-DLL1 Antibody with Anti-Tumor Efficacy against Estrogen Receptor-Positive Breast Cancer". Cancers 13 16 (2021): 4074. http://dx.doi.org/10.3390/cancers13164074.
    10.3390/cancers13164074
  14. Castro, Rute; Nobre, Lígia S.; Eleutério, Rute P.; Thomaz, Mónica; Pires, António; Monteiro, Sandra M.; Mendes, Sónia; et al. "Production of high-quality SARS-CoV-2 antigens: impact of bioprocess and storage on glycosylation, biophysical attributes, and ELISA serologic tests performance". Biotechnology and Bioengineering (2021): http://dx.doi.org/10.1002/bit.27725.
    10.1002/bit.27725
  15. Abel, Yoann; Paiva, Ana C F; Bizarro, Jonathan; Chagot, Marie-Eve; Santo, Paulo E; Robert, Marie-Cécile; Quinternet, Marc; et al. "NOPCHAP1 is a PAQosome cofactor that helps loading NOP58 on RUVBL1/2 during box C/D snoRNP biogenesis". Nucleic Acids Research 49 2 (2021): 1094-1113. http://dx.doi.org/10.1093/nar/gkaa1226.
    Publicado • 10.1093/nar/gkaa1226
  16. Sales-Dias, Joana; Ferreira, Andreia; Lamy, Marcia; Domenici, Giacomo; Monteiro, Sandra M. S.; Pires, Antonio; Lemos, Ana R.; et al. "Development of antibodies against the notch ligand Delta-Like-1 by phage display with activity against breast cancer cells". New Biotechnology (2021): https://publons.com/publon/46447014/.
    10.1016/J.NBT.2021.05.003
  17. Seixas, João D.; Sousa, Bárbara B.; Marques, Marta C.; Guerreiro, Ana; Traquete, Rui; Rodrigues, Tiago; Albuquerque, Inês S.; et al. "Structural and biophysical insights into the mode of covalent binding of rationally designed potent BMX inhibitors". RSC Chemical Biology 1 4 (2020): 251-262. http://dx.doi.org/10.1039/d0cb00033g.
    10.1039/d0cb00033g
  18. Zuhra, Karim; Sousa, Pedro M. F.; Paulini, Giulia; Lemos, Ana Rita; Kalme, Zenta; Bisenieks, Imants; Bisenieks, Egils; et al. "Screening Pyridine Derivatives against Human Hydrogen Sulfide-synthesizing Enzymes by Orthogonal Methods". Scientific Reports 9 1 (2019): http://dx.doi.org/10.1038/s41598-018-36994-w.
    10.1038/s41598-018-36994-w
  19. Romao, C.V.; Matias, P.M.; Sousa, C.M.; Pinho, F.G.; Pinto, A.F.; Teixeira, M.; Bandeiras, T.M.. "Insights into the Structures of Superoxide Reductases from the Symbionts Ignicoccus hospitalis and Nanoarchaeum equitans". Biochemistry 57 36 (2018): 5271-5281. http://www.scopus.com/inward/record.url?eid=2-s2.0-85049210698&partnerID=MN8TOARS.
    10.1021/acs.biochem.8b00334
  20. Silva, S.T.N.; Brito, J.A.; Arranz, R.; Sorzano, C.Ó.S.; Ebel, C.; Doutch, J.; Tully, M.D.; et al. "X-ray structure of full-length human RuvB-Like 2 – mechanistic insights into coupling between ATP binding and mechanical action". Scientific Reports 8 1 (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85053332823&partnerID=MN8TOARS.
    10.1038/s41598-018-31997-z
  21. Ferreira, A.; Lamy, M.; Margarida Rocha, M.; Silva, G.; Bandeiras, T.M.; Barbas, A.. "Production and characterization of a novel Delta-like 1 functional unit as a tool for Notch pathway activation and generation of a specific antibody". Protein Expression and Purification 146 (2018): 8-16. http://www.scopus.com/inward/record.url?eid=2-s2.0-85041619569&partnerID=MN8TOARS.
    10.1016/j.pep.2018.01.008
  22. Maurizy, C.; Quinternet, M.; Abel, Y.; Verheggen, C.; Santo, P.E.; Bourguet, M.; Paiva, A.C.F.; et al. "The RPAP3-Cterminal domain identifies R2TP-like quaternary chaperones". Nature Communications 9 1 (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85047874307&partnerID=MN8TOARS.
    10.1038/s41467-018-04431-1
  23. Zuhra, Karim; Sousa, Pedro M. F.; Paulini, Giulia; Lemos, Ana Rita; Kalme, Zenta; Bisenieks, Imants; Bisenieks, Egils; et al. "Searching for inhibitors of human H2S-synthesizing enzymes by orthogonal methods". Free Radical Biology and Medicine (2018): https://publons.com/wos-op/publon/10807758/.
    10.1016/J.FREERADBIOMED.2018.04.509
  24. Clarke, T.L.; Sanchez-Bailon, M.P.; Chiang, K.; Reynolds, J.J.; Herrero-Ruiz, J.; Bandeiras, T.M.; Matias, P.M.; et al. "PRMT5-Dependent Methylation of the TIP60 Coactivator RUVBL1 Is a Key Regulator of Homologous Recombination". Molecular Cell 65 5 (2017): 900-916.e7. http://www.scopus.com/inward/record.url?eid=2-s2.0-85013633978&partnerID=MN8TOARS.
    10.1016/j.molcel.2017.01.019
  25. Vicente, J.B.; Colaço, H.G.; Malagrinò, F.; Santo, P.E.; Gutierres, A.; Bandeiras, T.M.; Leandro, P.; Brito, J.A.; Giuffrè, A.. "A Clinically Relevant Variant of the Human Hydrogen Sulfide-Synthesizing Enzyme Cystathionine ß -Synthase: Increased CO Reactivity as a Novel Molecular Mechanism of Pathogenicity?". Oxidative Medicine and Cellular Longevity 2017 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85017139205&partnerID=MN8TOARS.
    10.1155/2017/8940321
  26. Romão, C.V.; Vicente, J.B.; Borges, P.T.; Victor, B.L.; Lamosa, P.; Silva, E.; Pereira, L.; et al. "Structure of Escherichia coli Flavodiiron Nitric Oxide Reductase". Journal of Molecular Biology 428 23 (2016): 4686-4707. http://www.scopus.com/inward/record.url?eid=2-s2.0-84996538192&partnerID=MN8TOARS.
    10.1016/j.jmb.2016.10.008
  27. Alves, M.; Lamego, J.; Bandeiras, T.; Castro, R.; Tomás, H.; Coroadinha, A.S.; Costa, J.; Simplício, A.L.. "Human carboxylesterase 2: Studies on the role of glycosylation for enzymatic activity". Biochemistry and Biophysics Reports 5 (2016): 105-110. http://www.scopus.com/inward/record.url?eid=2-s2.0-84949187250&partnerID=MN8TOARS.
    10.1016/j.bbrep.2015.11.018
  28. Colaço, H.G.; Santo, P.E.; Matias, P.M.; Bandeiras, T.M.; Vicente, J.B.. "Roles of Escherichia coli ZinT in cobalt, mercury and cadmium resistance and structural insights into the metal binding mechanism". Metallomics 8 3 (2016): 327-336. http://www.scopus.com/inward/record.url?eid=2-s2.0-84961244965&partnerID=MN8TOARS.
    10.1039/c5mt00291e
  29. Barbas, Ana; Lamy, Marcia; Ferreira, Andreia; Galvao, Joana; Braga, Sofia; Bandeiras, Tiago; Silva, Gabriela. "Development of novel biotherapeutics for breast cancer: generation of function blocking antibodies against Notch1 ligands". New Biotechnology (2016): https://publons.com/wos-op/publon/43912251/.
    10.1016/J.NBT.2016.06.889
  30. Zaarur, N.; Xu, X.; Lestienne, P.; Meriin, A.B.; McComb, M.; Costello, C.E.; Newnam, G.P.; et al. "RuvbL1 and RuvbL2 enhance aggresome formation and disaggregate amyloid fibrils". EMBO Journal 34 18 (2015): 2363-2382. http://www.scopus.com/inward/record.url?eid=2-s2.0-84941732990&partnerID=MN8TOARS.
    10.15252/embj.201591245
  31. Sousa, C.M.; Carpentier, P.; Matias, P.M.; Testa, F.; Pinho, F.; Sarti, P.; Giuffrè, A.; Bandeiras, T.M.; Romão, C.V.. "Superoxide reductase from Giardia intestinalis: Structural characterization of the first SOR from a eukaryotic organism shows an iron centre that is highly sensitive to photoreduction". Acta Crystallographica Section D: Biological Crystallography 71 (2015): 2236-2247. http://www.scopus.com/inward/record.url?eid=2-s2.0-84946606061&partnerID=MN8TOARS.
    10.1107/S1399004715015825
  32. Matias, P.M.; Baek, S.H.; Bandeiras, T.M.; Dutta, A.; Houry, W.A.; Llorca, O.; Rosenbaum, J.. "The AAA+ proteins Pontin and Reptin enter adult age: From understanding their basic biology to the identification of selective inhibitors". Frontiers in Molecular Biosciences 2 MAY (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84956964981&partnerID=MN8TOARS.
    10.3389/fmolb.2015.00017
  33. Lamosa, P.; Lourenço, E.C.; d’Avó, F.; Nobre, A.; Bandeiras, T.M.; da Costa, M.S.; Ventura, M.R.; Santos, H.. "A unique glyceryl diglycoside identified in the thermophilic, radiation-resistant bacterium Rubrobacter xylanophilus". Extremophiles 19 2 (2015): 373-382. http://www.scopus.com/inward/record.url?eid=2-s2.0-84925532850&partnerID=MN8TOARS.
    10.1007/s00792-014-0723-0
  34. Bandeiras, T.M.; Freitas, M.C.; Petrasch, D.; Kletzin, A.; Frazão, C.. "SAD phasing towards structure determination of a thermostable Rieske ferredoxin with a novel stabilizing disulfide bridge". Acta Crystallographica Section F: Structural Biology and Crystallization Communications 69 5 (2013): 555-558. http://www.scopus.com/inward/record.url?eid=2-s2.0-84882342812&partnerID=MN8TOARS.
    10.1107/S1744309113008385
  35. Sousa, C. M.; Pinto, A. F.; Rodrigues, J. V.; Teixeira, M.; Matias, P. M.; Romao, C. V.; Bandeiras, T. M.. "Structural determinants of superoxide reduction". European Biophysics Journal (2013): https://publons.com/wos-op/publon/4049406/.
  36. Santos, S.P.; Bandeiras, T.M.; Pinto, A.F.; Teixeira, M.; Carrondo, M.A.; Romão, C.V.. "Thermofluor-based optimization strategy for the stabilization and crystallization of Campylobacter jejuni desulforubrerythrin". Protein Expression and Purification 81 2 (2012): 193-200. http://www.scopus.com/inward/record.url?eid=2-s2.0-81155128023&partnerID=MN8TOARS.
    10.1016/j.pep.2011.10.001
  37. Carvalho-Santos, Z.; Machado, P.; Alvarez-Martins, I.; Gouveia, S.; Jana, S.; Duarte, P.; Amado, T.; et al. "BLD10/CEP135 Is a Microtubule-Associated Protein that Controls the Formation of the Flagellum Central Microtubule Pair". Developmental Cell 23 2 (2012): 412-424. http://www.scopus.com/inward/record.url?eid=2-s2.0-84865103367&partnerID=MN8TOARS.
    10.1016/j.devcel.2012.06.001
  38. Gorynia, S.; Bandeiras, T.M.; Pinho, F.G.; McVey, C.E.; Vonrhein, C.; Round, A.; Svergun, D.I.; et al. "Structural and functional insights into a dodecameric molecular machine - The RuvBL1/RuvBL2 complex". Journal of Structural Biology 176 3 (2011): 279-291. http://www.scopus.com/inward/record.url?eid=2-s2.0-80455176998&partnerID=MN8TOARS.
    10.1016/j.jsb.2011.09.001
  39. Pinho, F.G.; Pinto, A.F.; Pinto, L.C.; Huber, H.; Romão, C.V.; Teixeira, M.; Matias, P.M.; Bandeiras, T.M.. "Superoxide reductase from Nanoarchaeum equitans: Expression, purification, crystallization and preliminary X-ray crystallographic analysis". Acta Crystallographica Section F: Structural Biology and Crystallization Communications 67 5 (2011): 591-595. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955667521&partnerID=MN8TOARS.
    10.1107/S1744309111009432
  40. Bandeiras, Tiago M.; Gorynia, Sabine; Vonrhein, Clemens; Donner, Peter; Matias, Pedro M.; Carrondo, Maria Armenia. "Structural insights into a dodecameric machine - The RuvBL1/RuvBL2 complex". Acta Crystallographica Section A: Foundations and Advances (2011): https://publons.com/publon/28024950/.
    10.1107/S0108767311093329
  41. Pinho, F.G.; Romão, C.V.; Pinto, A.F.; Saraiva, L.M.; Huber, H.; Matias, P.M.; Teixeira, M.; Bandeiras, T.M.. "Cloning, purification, crystallization and X-ray crystallographic analysis of Ignicoccus hospitalis neelaredoxin". Acta Crystallographica Section F: Structural Biology and Crystallization Communications 66 5 (2010): 605-607. http://www.scopus.com/inward/record.url?eid=2-s2.0-77952007051&partnerID=MN8TOARS.
    10.1107/S1744309110012030
  42. Bandeiras, T.M.; Romão, C.V.; Rodrigues, J.V.; Teixeira, M.; Matias, P.M.. "Purification, crystallization and X-ray crystallographic analysis of Archaeoglobus fulgidus neelaredoxin". Acta Crystallographica Section F: Structural Biology and Crystallization Communications 66 3 (2010): 316-319. http://www.scopus.com/inward/record.url?eid=2-s2.0-77749273980&partnerID=MN8TOARS.
    10.1107/S1744309110000916
  43. Brito, J.A.; Sousa, F.L.; Stelter, M.; Bandeiras, T.M.; Vonrhein, C.; Teixeira, M.; Pereira, M.M.; Archer, M.. "Structural and functional insights into sulfide:quinone oxidoreductase". Biochemistry 48 24 (2009): 5613-5622. http://www.scopus.com/inward/record.url?eid=2-s2.0-67649205368&partnerID=MN8TOARS.
    10.1021/bi9003827
  44. Bandeiras, T.M.; Refojo, P.N.; Todorovic, S.; Murgida, D.H.; Hildebrandt, P.; Bauer, C.; Pereira, M.M.; Kletzin, A.; Teixeira, M.. "The cytochrome ba complex from the thermoacidophilic crenarchaeote Acidianus ambivalens is an analog of bc1 complexes". Biochimica et Biophysica Acta - Bioenergetics 1787 1 (2009): 37-45. http://www.scopus.com/inward/record.url?eid=2-s2.0-57649183890&partnerID=MN8TOARS.
    10.1016/j.bbabio.2008.09.009
  45. Gorynia, S.; Matias, P.M.; Bandeiras, T.M.; Donner, P.; Carrondo, M.A.. "Cloning, expression, purification, crystallization and preliminary X-ray analysis of the human RuvBL1-RuvBL2 complex". Acta Crystallographica Section F: Structural Biology and Crystallization Communications 64 9 (2008): 840-846. http://www.scopus.com/inward/record.url?eid=2-s2.0-51149096210&partnerID=MN8TOARS.
    10.1107/S174430910802558X
  46. Bandeiras, T.M.; Hillig, R.C.; Matias, P.M.; Eberspaecher, U.; Fanghänel, J.; Thomaz, M.; Miranda, S.; et al. "Structure of wild-type Plk-1 kinase domain in complex with a selective DARPin". Acta Crystallographica Section D: Biological Crystallography 64 4 (2008): 339-353. http://www.scopus.com/inward/record.url?eid=2-s2.0-41949142073&partnerID=MN8TOARS.
    10.1107/S0907444907068217
  47. Carrondo, Maria A.; Hillig, Roman C.; Bandeiras, Tiago M.; Matias, Pedro M.; Eberspaecher, Uwe; Fanghanel, Jorg; Thomaz, Monica; et al. "Structure of wild type Plk1 kinase domain in complex with a selective DARPin". Acta Crystallographica Section A: Foundations and Advances (2008): https://publons.com/publon/28024943/.
    10.1107/S0108767308091290
  48. Brito, J.A.; Bandeiras, T.M.; Teixeira, M.; Vonrhein, C.; Archer, M.. "Crystallisation and preliminary structure determination of a NADH: quinone oxidoreductase from the extremophile Acidianus ambivalens". Biochimica et Biophysica Acta - Proteins and Proteomics 1764 4 (2006): 842-845. http://www.scopus.com/inward/record.url?eid=2-s2.0-33646479786&partnerID=MN8TOARS.
    10.1016/j.bbapap.2005.09.015
  49. Bandeiras, T.M.; Pereira, M.M.; Teixeira, M.; Moenne-Loccoz, P.; Blackburn, N.J.. "Structure and coordination of CuB in the Acidianus ambivalens aa3 quinol oxidase heme-copper center". Journal of Biological Inorganic Chemistry 10 6 (2005): 625-635. http://www.scopus.com/inward/record.url?eid=2-s2.0-27944451044&partnerID=MN8TOARS.
    10.1007/s00775-005-0012-6
  50. Kletzin, A.; Ferreira, A.S.; Hechler, T.; Bandeiras, T.M.; Teixeira, M.; Gomes, C.M.. "A Rieske ferredoxin typifying a subtype within Rieske proteins: Spectroscopic, biochemical and stability studies". FEBS Letters 579 5 (2005): 1020-1026. http://www.scopus.com/inward/record.url?eid=2-s2.0-13844273334&partnerID=MN8TOARS.
    10.1016/j.febslet.2004.12.075
  51. Todorovic, S.; Pereira, M.M.; Bandeiras, T.M.; Teixeira, M.; Hildebrandt, P.; Murgida, D.H.. "Midpoint potentials of hemes a and a3 in the quinol oxidase from Acidianus ambivalens are inverted". Journal of the American Chemical Society 127 39 (2005): 13561-13566. http://www.scopus.com/inward/record.url?eid=2-s2.0-25844475284&partnerID=MN8TOARS.
    10.1021/ja052921l
  52. Kletzin, A.; Urich, T.; Müller, F.; Bandeiras, T.M.; Gomes, C.M.. "Dissimilatory Oxidation and Reduction of Elemental Sulfur in Thermophilic Archaea". Journal of Bioenergetics and Biomembranes 36 1 (2004): 77-91. http://www.scopus.com/inward/record.url?eid=2-s2.0-10044244502&partnerID=MN8TOARS.
    10.1023/B:JOBB.0000019600.36757.8c
  53. Pereira, M.M.; Bandeiras, T.M.; Fernandes, A.S.; Lemos, R.S.; Melo, A.M.P.; Teixeira, M.. "Respiratory Chains from Aerobic Thermophilic Prokaryotes". Journal of Bioenergetics and Biomembranes 36 1 (2004): 93-105. http://www.scopus.com/inward/record.url?eid=2-s2.0-10344244184&partnerID=MN8TOARS.
    10.1023/B:JOBB.0000019601.74394.67
  54. Urich, T.; Bandeiras, T.M.; Leal, S.S.; Rachel, R.; Albrecht, T.; Zimmermann, P.; Scholz, C.; et al. "The sulphur oxygenase reductase from Acidianus ambivalens is a multimeric protein containing a low-potential mononuclear non-haem iron centre". Biochemical Journal 381 1 (2004): 137-146. http://www.scopus.com/inward/record.url?eid=2-s2.0-3142776185&partnerID=MN8TOARS.
    10.1042/BJ20040003
  55. Das, T.K.; Gomes, C.M.; Bandeiras, T.M.; Pereira, M.M.; Teixeira, M.; Rousseau, D.L.. "Active site structure of the aa3 quinol oxidase of Acidianus ambivalens". Biochimica et Biophysica Acta - Bioenergetics 1655 1-3 (2004): 306-320. http://www.scopus.com/inward/record.url?eid=2-s2.0-1942440337&partnerID=MN8TOARS.
    10.1016/j.bbabio.2003.08.011
  56. Melo, A.M.P.; Bandeiras, T.M.; Teixeira, M.. "New insights into type II NAD(P)H:quinone oxidoreductases". Microbiology and Molecular Biology Reviews 68 4 (2004): 603-616. http://www.scopus.com/inward/record.url?eid=2-s2.0-10344231976&partnerID=MN8TOARS.
    10.1128/MMBR.68.4.603-616.2004
  57. Müller, F.H.; Bandeiras, T.M.; Urich, T.; Teixeira, M.; Gomes, C.M.; Kletzin, A.. "Coupling of the pathway of sulphur oxidation to dioxygen reduction: Characterization of a novel membrane-bound thiosulphate:quinone oxidoreductase". Molecular Microbiology 53 4 (2004): 1147-1160. http://www.scopus.com/inward/record.url?eid=2-s2.0-4344594427&partnerID=MN8TOARS.
    10.1111/j.1365-2958.2004.04193.x
  58. Bandeiras, T.M.; Salgueiro, C.A.; Huber, H.; Gomes, C.M.; Teixeira, M.. "The respiratory chain of the thermophilic archaeon Sulfolobus metallicus: Studies on the type-II NADH dehydrogenase". Biochimica et Biophysica Acta - Bioenergetics 1557 1-3 (2003): 13-19. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037422395&partnerID=MN8TOARS.
    10.1016/S0005-2728(02)00374-2
  59. Bandeiras, T.M.; Salgueiro, C.; Kletzin, A.; Gomes, C.M.; Teixeira, M.. "Acidianus ambivalens type-II NADH dehydrogenase: Genetic characterisation and identification of the flavin moiety as FMN". FEBS Letters 531 2 (2002): 273-277. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037032427&partnerID=MN8TOARS.
    10.1016/S0014-5793(02)03514-7
  60. Gomes, C.M.; Bandeiras, T.M.; Teixeira, M.. "A new type-II NADH dehydrogenase from the archaeon acidianus ambivalens: Characterization and in vitro reconstitution of the respiratory chain". Journal of Bioenergetics and Biomembranes 33 1 (2001): 1-8. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035070335&partnerID=MN8TOARS.
    10.1023/A:1005630221892
  61. Bandeiras, TM; Gomes, CM; Teixeira, M. "Insights into archaeal type-II NADH dehydrogenases". Journal of Inorganic Biochemistry (2001): https://publons.com/publon/30481698/.
Livro
  1. Gorynia, S.; Bandeiras, T.M.; Matias, P.M.; Pinho, F.G.; McVey, C.E.; Donner, P.; Carrondo, M.A.. RuvBL1 and RuvBL2 and their complex proteins implicated in many cellular pathways. 2012.
    10.1007/978-94-007-2530-0_5
Poster em conferência
  1. Pires, Carolina; Marques, Inês J.; Saramago, Ana; Santo, Paulo E.; Leite, Valeriano; Vicente, João B.; M. Bandeiras, Tiago; Cavaco, Branca. "Identification of CHEK2 as a candidate predisposing gene for familial non-medullary thyroid carcinoma". Trabalho apresentado em Encontro com a Ciência e Tecnologia em Portugal, 2022.
  2. Pires, Carolina; Marques, I. J.; Saramago, Ana; Santo, P. E.; Leite, Valeriano; Vicente, João B.; M. Bandeiras, Tiago; Cavaco, Branca. "Identification of a likely pathogenic variant in CHEK2 in a Portuguese family with familial non-medullary thyroid cancer". Trabalho apresentado em II ASPIC-ASEICA INTERNATIONAL MEETING - CURRENT TRENDS IN PRECISION MEDICINE IN CANCER, 2021.
Resumo em conferência
  1. "NOP58 assembly to Box C/D snoRNP involves NOPCHAP1 as a bridge with the PAQosome chaperone". Trabalho apresentado em EMBO Workshop - Ribosome synthesis, Engelberg, 2022.
    Submetido

Outros

Outra produção
  1. Rationally Designed Potent BMX Inhibitors Reveals Mode of Covalent Binding at the Atomic Level. 2020. M. Bandeiras, Tiago. https://doi.org/10.26434/chemrxiv.11558310.v1.
    10.26434/chemrxiv.11558310.v1
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2020/12/04 Seamless Integration of Satellite Labs @ IBET in drug development programs Science4All
Merck SA (Lisbon, Portugal)
2020/11/18 Seamless Integration of Satellite Labs @ IBET DDTech Forum at Merck KGaA
Merck KGaA (Darmstadt, Alemanha)
2017/02/08 Cristalografia aplicada a ciência e a Indústria JORTEC - Jornadas Tecnológicas dos alunos de Química Aplicada (FCT-UNL)
Universidade Nova de Lisboa, Faculdade de Ciências e Tecnologia (Monte da Caparica, Portugal)
2014/11/05 Assessing a stable p70S6K kinase domain for iterative structure-based drug discovery Protein Structure Determination in Industry, Cascais, Portugal, 2-5th November, 2014
Merck KGaA (Cascais, Portugal)
2010/01/19 Structure-based drug design approaches for preclinical projects INTERBIO initiative – the organization of a thematic meeting (Structure/Function of proteins and drug design and Regenerative medicine and stem cells), Valencia, Spain, 18-21 January 2010
Interbio (Valencia, Espanha)
2008/10/11 Thermofluor and Limited Proteolysis Approaches Biocrys Course on Macromolecular Crystallography, 04-11 October, 2008.
ITQB-UNL (Oeiras, Portugal)
2008/07/13 Structure of wild-type Plk-1 kinase domain in complex with a selective DARPin 1st Portuguese-Spanish-British Joint Biophysics Congress, Lisbon, Portugal, 10-13th July, 2008
Portuguese Biophysics Society (Lisbon, Portugal)
2006/06/20 Cytochrome bc1 analogous complex from the hyperthermoacidophilic crenarchaeon Acidianus ambivalens the 1st International Workshop on Expression, Function and Structure of Membrane Proteins, Florence, Italy, June 18-22, 2006
Centro di Ricerca di Risonanze Magnetiche, Firenze, Italia (Florence, Itália)
2005/11/01 Archaeal Respiratory Chains: Coupling sulfur to oxygen metabolism PhD course at Institut of Microbiology and Genetics, Darmstadt University of Technology, Darmstadt, Germany, November, 2005
Darmstadt University of Technology, Darmstadt (Darmstadt, Alemanha)

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2021/01/01 - Atual Understanding box HACA snoRNP biogenesis _ The role of DKC1 and SHQ1 proteins in cancer
Coorientador de Philipp Busse
 Biociências Moleculares (Doutoramento)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Instituto de Biologia Experimental e Tecnológica, Portugal
2017/01/01 - Atual Cyclophilin D as a multiple sclerosis and cardiovascular disease drug target
Orientador de Diana Oliveira Silva
 Biociências Moleculares (Doutoramento)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2020/01/01 - 2025/06/30 Deeper insights into small molecule mode of target modulation by novel biophysical methods
Coorientador de Catarina Félix Malta
 Biociências Moleculares (Doutoramento)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Instituto de Biologia Experimental e Tecnológica, Portugal
2019/09/01 - 2025/05/16 Structure and Function of a molecular machine: Human RuvBL1/2 complex and its role in human disease
Orientador de Ana Catarina Fernandes Paiva
 Biociências Moleculares (Doutoramento)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2016/01/01 - 2021/06/29 Human RuvBL1/2 complex and its role in human disease
Orientador de Paulo Espirito Santo
Biociências Moleculares (Doutoramento)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2016/01/01 - 2021/04/19 Therapeutic Targets for Triple Negative Breast Cancer: Development of mono and bispecific antibodies against Notch1 ligands
Coorientador de Joana Sales Dias
Biociências Moleculares (Doutoramento)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2007/09/01 - 2019/02/15 Cyclophilin D as a multiple sclerosis and cardiovascular disease drug target
Orientador de Micael Correia Freitas
 Bioquímica para a Saúde (Mestrado)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2017/02/01 - 2018/11/20 Structure and Function of a molecular machine: Human RuvBL1/2 complex and its role in human disease
Orientador de Ana Catarina Fernandes Paiva
 Engenharia Biológica (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal

Instituto de Biologia Experimental e Tecnológica, Portugal
2012/01/01 - 2017/11/27 Structural insights into the human multifunctional protein RuvBL2
Coorientador de Sara Teresa Neves da Silva
 Biociências Moleculares (Doutoramento)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2017/01/01 - 2017/07/01 Biotinilação in vivo no desenvolvimento de novos fármacos
Orientador
 Biologia Funcional (Mestrado)
Universidade de Lisboa Instituto Superior de Agronomia, Portugal
2014/09/01 - 2015/11/27 Phage Display as a tool for generation of bio-therapeutic agents for Breast Cancer
Coorientador de Andreia Teixeira Ferreira
 Genética Molecular e Biomedicina (Mestrado)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Instituto de Biologia Experimental e Tecnológica, Portugal
2013/09/01 - 2014/10/21 Assessment of Notch1 Ligands production-Key Protein Targets in Breast Cancer
Orientador de Maria Margarida dos Santos Silva
 Genética Molecular e Biomedicina (Mestrado)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Instituto de Biologia Experimental e Tecnológica, Portugal

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação) 		Instituição / Organização
2014/01/01 - 2014/11/10 Co-organizer, together with Merck KGaA scientists, of the PSDI 2014 (Protein Structure Determination in Industry) meeting, 2-5 November 2014, held at the Miragem Hotel, Cascais, Portugal. (2014/11/02 - 2014/11/05)
Congresso (Membro da Comissão Organizadora)
 Instituto de Biologia Experimental e Tecnológica, Portugal

Merck KGaA, Alemanha
2014/01/01 - 2014/10/14 Co-organizer of the 2nd International Workshop on Pontin and Reptin, Oeiras, Portugal, 10-12 October 2014. (2014/10/10 - 2014/10/12)
Congresso (Membro da Comissão Organizadora)
 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2010/01/01 - 2010/10/18 Member of the organizing committee of the BioCrys 2010 “Fundamentals of Morden Methods in Biocrystallography” FEBS Practical & Lecture Course 9-16 October 2010, Oeiras, Portugal (2010/10/09 - 2010/10/16)
Oficina (workshop) (Coorganizador)
 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2008/01/01 - 2008/10/12 Member of the organizing committee of the BioCrys Course: Macromolecular Crystallography in 2008, ITQB, Oeiras, Portugal. (2008/10/04 - 2008/10/11)
Oficina (workshop) (Coorganizador)
 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2005/03/01 - 2005/09/25 Member of the organizing committee of the 1st ESF & MAX INF2 Course on Membrane proteins - the rocky road from gene to structure, ITQB, Oeiras, Portugal, 19-24 September 2005. (2005/09/19 - 2005/09/24)
Congresso (Membro da Comissão Organizadora)
 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2001/06/15 - 2001/07/06 Co-organizer of the FEBS Lisbon 2001, 27th Meeting of the Federation of European Biochemical Societies. Lisboa, Portugal, 30 June-5 July 2001. (2001/06/30 - 2001/07/05)
Congresso (Coorganizador)
 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Júri de grau académico

Tema
Tipo de participação 		Nome do candidato (Tipo de grau)
Instituição / Organização
2019/09/30 Cell-based switch-on sensors for detection and quantification of label-free viruses
Arguente
 Miguel Ricardo Guerreiro (Doutoramento)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Instituto de Biologia Experimental e Tecnológica, Portugal
2016/11/23 Production, Biochemical Characterisation and Stability Assessment of Human IgG4 Therapeutic Antibodies in Comparison to Other Isotypes
Arguente principal
 Khrystyna Kucheryava (Mestrado)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2016/07/11 Structural and Functional Studies on the reactivity of CORMs with plasma proteins
Arguente
 Marino Filipe Alves dos Santos (Doutoramento)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2015/11/12 Staying under the radar” - The Multifunctional LANA Protein
Arguente principal
 Tânia Filipa Fernandes dos Santos Alves Custódio (Mestrado)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2015/07/30 Analysis of CFTR mutants in Epithelial Cells/Tissues and Testing of CFTR-Repairing Therapies
Arguente
 Inna Uliyakina (Doutoramento)
Universidade de Lisboa Faculdade de Ciências, Portugal
2013/12/20 Synthesis of new enzyme stabilisers inspired by compatible solutes of hyperthermophilic microorganisms
Arguente
 Eva Correia Lourenço (Doutoramento)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2012/12/12 Caracterização estrutural de enzimas de molibdénio e suas chaperonas
Arguente principal
 Ana Rita Cardoso (Mestrado)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2011/12/20 Production and characterization of the biological activity of peptides obtained via hydrolysis from whey proteins by cardosins
Arguente
 Tânia Sofia Granja Tavares (Doutoramento)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2011/01/19 Fragment-Based Lead Discovery - A Case Study with the c-AMP Dependent Kinase", Master in Chemical and Biochemical Engineering
Arguente principal
 Sílvia Alexandra Leal Santos (Mestrado)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Arbitragem científica em revista

Nome da revista (ISSN) Editora
2016/12/01 - 2016/12/31 Metallomics (1756-591X) The Royal Society of Chemistry
2006/04/03 - 2007/12/28 JBIC Journal of Biological Inorganic Chemistry (1432-1327) Springer-Verlag

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2009/01/01 - Atual Structural Biology in Drug Discovery Biociências Moleculares (Doutoramento) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2019/11/11 - 2019/11/11 A structural overview of Pontin, Reptin and their complexes Biociências Moleculares (Doutoramento) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2003/09/01 - 2005/09/01 Bioenergetics; Enzymology and Regulation 1 and 2 Biologia (Licenciatura) Universidade Lusófona de Humanidades e Tecnologias, Portugal
Distinções

Prémio

2012 Pfizer Award for Basic Sciences 2012
Pfizer Portugal, Portugal